CN106727720A

CN106727720A - A kind of medicine for garget and preparation method thereof

Info

Publication number: CN106727720A
Application number: CN201611143023.3A
Authority: CN
Inventors: 蒋勇
Original assignee: SICHUAN XIYA ANIMAL PHARMACEUTICAL CO Ltd
Current assignee: SICHUAN XIYA ANIMAL PHARMACEUTICAL CO Ltd
Priority date: 2016-12-13
Filing date: 2016-12-13
Publication date: 2017-05-31

Abstract

The invention discloses a kind of medicine for garget and preparation method thereof, in the transparent solution shape of maroon, wherein the solvent in solution is the ethanol water that mass fraction is 50% 90% to the medicine, and the solute in solution is made up of the raw material of following concentration：The 1000mg/L of geniposide 200, the 50mg/L of propolis 20；Geniposide in the present invention is capejasmine extract, the effect with anti-inflammatory, and propolis, alcohol play the effect of sterilizing, and triplicity is mutually promoted, the further anti-inflammatory on the basis of sterilizing, can effectively treat, prevents and control garget；Geniposide is the medicine beneficial to human body with propolis, while treatment, prevention and control garget, unharmful substance residual, it is to avoid influence public health health；Easy to use, it is fried or crush the method for administration that gavages to be not limited to herbal mixture, can be applied directly on cow's milk, has no toxic side effect.

Description

A kind of medicine for garget and preparation method thereof

Technical field

The invention belongs to garget Prevention field, and in particular to a kind of medicine and its preparation for garget Method.

Background technology

Mammitis is a kind of common multiple diseases of milk cow, its pathogenic factor be due to pathogen intrusion and cause The various inducements of infection, such as wound, Milking Methods And Techniques are not good, environmental sanitation is bad, feeding and management is inappropriate, and hormonal imbalance, breast lack Sunken and other diseases induction etc., is one of three big important diseases of milk cow, in the global annual economy caused by mastitis for milk cows Loss reaches multi-million dollar, while the also quality of influence milk output and its dairy produce.For a long time, mastitis for milk cows is controlled Treat, it is main both at home and abroad to use antibiotic and chemical synthetic drug, but above most outstanding problem to show as medicine residual in milk Stay；Secondly, long-term use can cause the serious drug resistance of cow breast flora generation and public health health is caused harm Etc. consequence.The tradition of China's useful treatment by Chinese herbs livestock mammitis since ancient times, but it is fried or crush to be confined to herbal mixture The method of administration for gavaging, complex operation, medication is inconvenient.

The content of the invention

It is an object of the present invention to provide a kind of medicine for garget and preparation method thereof, be garget treatment and Prevention provides a kind of new medicine.

The technical scheme is that：A kind of medicine for garget, the medicine is in the transparent solution shape of maroon, its Solvent in middle solution is the ethanol water that mass fraction is 50%-90%, solute in solution by following concentration raw material Composition：

Geniposide 200-1000mg/L

Propolis 20-50mg/L.

More excellent, the solvent in the solution is the ethanol water that mass fraction is 60%, the solute in solution by with The raw material composition of lower concentration：

Geniposide 500mg/L

Propolis 30mg/L.

More excellent, the solvent in the solution is the ethanol water that mass fraction is 80%, the solute in solution by with The raw material composition of lower concentration：

Geniposide 400mg/L

Propolis 40mg/L.

A kind of preparation method of medicine for garget, comprises the following steps：

(1) propolis is substantially soluble in more than 96% ethanol, in course of dissolution, it is 40-50 DEG C, mistake to keep solution temperature It is standby that filter obtains maroon clear solution；

(2) geniposide is dissolved in deionized water, obtains colourless transparent solution standby；

(3) colourless transparent solution that the transparent solution of the maroon that obtains (1) and (2) obtain is according to certain volume than mixed It is molten.

The present invention has the following advantages that compared with prior art：

(1) geniposide in the present invention is capejasmine extract, the effect with anti-inflammatory, and propolis, alcohol play sterilizing Effect, triplicity mutually promotes, and further anti-inflammatory, can effectively treat, prevents and control ox on the basis of sterilizing Mammitis；

(2) geniposide is the medicine beneficial to human body with propolis, in the same for the treatment of, prevention and control garget When, unharmful substance residual, it is to avoid influence public health health；

(3) easy to use, it is fried or crush the method for administration that gavages to be not limited to herbal mixture, can be applied directly to cow's milk On, have no toxic side effect；Production process is simple；

(4) one is treated, prevents and be controlled in collection, and use of the invention is milked every time through whole nursery phase After smear, to put prevention first, medication is convenient, does not result in cow breast flora and produces serious drug resistance；

(5) there is certain antiinflammation in itself using the milk of the Cow product of this product, milk quality is high.

Specific embodiment

Embodiment 1

Prepared according to 1000ml liquids and calculated, the propolis for weighing 50mg is dissolved in the ethanol of 600ml 98%, course of dissolution In be sufficiently stirred for, keep solution temperature be 40-50 DEG C, dissolution time 3-4 hours, maroon clear solution is obtained after filtering；Claim again Take 500mg geniposides and be dissolved in 400ml deionized waters and obtain colourless transparent solution, it is left back by maroon clear solution with it is colourless Clear solution is miscible, micro- to be heated to 40-50 DEG C if separating out solid impurity, and using ultrasonic wave shake it is even after dress up 20 bottles of storages, This product is preserved under the conditions of normal temperature, lucifuge, cool place, and the term of validity is 3 years.

Embodiment 2

This product acts on milk cow experiment：

20 healthy cows at lactation initial stage, are equally divided into two groups of A, B, and every group 10, A groups milk cow is smeared after milking every time This product, B groups milk cow does not smear this product after milking every time, the generation without breast inflammation of A groups milk cow, B groups after testing 10 days Having two in milk cow has slight breast inflammation；Smeared successively at two groups of breast of milk cow Streptococcusagalactiae, streptococcus dysgalactiae, This product, after 10 days, A are smeared in gold-coloured staphylococci, Escherichia coli, streptococcus uberis and klebsiella, then A groups milk cow continuation Having one in group milk cow has slight breast inflammation, remaining generation without breast inflammation；B group milk cows have 8 cow heads produce compared with It is serious breast inflammation, there is slight breast inflammation at two；After 20 days, A groups milk cow is all without breast inflammation, and B group milk cows are equal Produce more serious breast inflammation.

Embodiment 3

Small white mouse drinks the antiinflammatory action experiment of the milk of the milk cow output for smearing product of the present invention：

40 small white mouses, 30 ± 2g of body weight is equally divided into two groups of a, b, and every group 20, male and female half and half, a groups are fed and smear this The milk of the milk cow output of invention product, b groups feed ordinary milk, by the same area of all small white mouses after feeding 5 days respectively Scratch, under identical bad border, a groups continue to feed the milk of the milk cow output for smearing product of the present invention, and b groups continue to feed common ox Milk.

After 3 days, a groups have 17 small white mouses without suppuration phenomenon, and 2 small white mouses are slightly suppurated, and 1 small white mouse severe is suppurated；b Group has 5 small white mouses without suppuration phenomenon, and 6 small white mouses are slightly suppurated, and 9 small white mouse severes are suppurated.

Embodiment described above only expresses the specific embodiment of the application, and its description is more specific and detailed, but simultaneously Therefore the limitation to the application protection domain can not be interpreted as.It should be pointed out that for one of ordinary skill in the art For, on the premise of technical scheme design is not departed from, various modifications and improvements can be made, these belong to this The protection domain of application.

Claims

1. a kind of medicine for garget, it is characterised in that the medicine in the transparent solution shape of maroon, wherein in solution Solvent is the ethanol water that mass fraction is 50%-90%, and the solute in solution is made up of the raw material of following concentration：

Geniposide 200-1000mg/L

Propolis 20-50mg/L.

2. a kind of medicine for garget according to claim 1, it is characterised in that the solvent in the solution is Mass fraction is 60% ethanol water, and the solute in solution is made up of the raw material of following concentration：

Geniposide 500mg/L

Propolis 30mg/L.

3. a kind of medicine for garget according to claim 1, it is characterised in that the solvent in the solution is Mass fraction is 80% ethanol water, and the solute in solution is made up of the raw material of following concentration：

Geniposide 400mg/L

Propolis 40mg/L.

4. the preparation method of a kind of medicine for garget as described in claim 1 or 2 or 3, it is characterised in that including Following steps：

(1) propolis is substantially soluble in more than 96% ethanol, in course of dissolution, it is 40-50 DEG C to keep solution temperature, is filtered It is standby to maroon clear solution；

(3) colourless transparent solution that the transparent solution of the maroon that obtains (1) and (2) obtain according to certain volume than it is miscible i.e. Can.