CN108096284A - A kind of Biological compound preparation for preventing mastitis for milk cows and preparation method thereof - Google Patents
A kind of Biological compound preparation for preventing mastitis for milk cows and preparation method thereof Download PDFInfo
- Publication number
- CN108096284A CN108096284A CN201711203037.4A CN201711203037A CN108096284A CN 108096284 A CN108096284 A CN 108096284A CN 201711203037 A CN201711203037 A CN 201711203037A CN 108096284 A CN108096284 A CN 108096284A
- Authority
- CN
- China
- Prior art keywords
- biological compound
- preparation
- compound preparation
- taken
- mastitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0041—Mammary glands, e.g. breasts, udder; Intramammary administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Insects & Arthropods (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides a kind of Biological compound preparations for preventing mastitis for milk cows and preparation method thereof, include following component described in per 100ml in Biological compound preparation：Propolis solution (propolis ethanol soluble extraction content >=50%) 5 30ml, 1 5g of notoginsenoside R, 2 8g of astragalus polyose, 0.5 2g of Sodium Hyaluronate, 2 10ml of glycerine, sodium chloride 0.9g, remaining is supplied with water for injection.The present invention is to be used to prevent and treat the breast injection of mastadenitis of cow in the dry milk phase, is the Biological compound preparation of hydrogel.The biomaterial preparation can effectively prevent mammitis of dairy cattle during nonlactating, can also coordinate treatment of the other medicines for clinical mammitis and recessive mastitis, improve the cure rate of mammitis, reduction treatment cost.
Description
Technical field
The invention belongs to biologic product technology fields for animals, and in particular to a kind of compound system of biology for preventing mastitis for milk cows
Agent and preparation method thereof is a kind of new bio compound formulation for being used to prevent and treat mastitis for milk cows.
Background technology
Mastitis for milk cows, which has become, endangers one of most common disease of milk cow production.The whole world there are about 2.2 hundred million cow heads,
Wherein have 1/3rd with various types of mammitises.According to statistics, the mammitis there are about 97% belongs to recessive mastitis.Often
Year loss caused by mammitis is up to 35,000,000,000 dollars.The survey showed that by Yuan Yonglong etc., China's milk cow clinic mastitis
Incidence average out to 33.41%, the average positive rate of recessive mastitis is 73.91%.
Mastitis for milk cows is mammary gland essence and interstitial group as caused by pathogenic microorganism invades breast or other stress factors
The inflammation knitted, not only influences milk production of cow, causes serious economic loss, and influences the quality of breast.Therefore, particularly
Recessive mastitis, the cause of disease is extremely complex, but fails to propose a thorough solution so far.Microorganism infection is to cause milk
The main reason for bovine mastitis.At present, it has been found that there are about 150 multiple pathogens can cause mastadenitis of cow.Wherein with grape ball
Based on bacterium, streptococcus and Escherichia coli, entire Isolated from Bovine Mastitis more than 90% is accounted for.Whether mastitis for milk cows removes
It is also closely related with the influence of the resistance and external environment of animal body with pathogen there are outside the Pass.
At present, mastitis for milk cows is prevented primarily directed to its pathogenesis using antibacterials and immunopotentiator.With
The continuous improvement of the food-safe requirement of people and the requirement that country is tightened up to quality of dairy products, clinical treatment milk cow
The common antibiotic of mammitis is since there are medicament residues and drug resistance problems, it will is gradually limited the use of or disabled, using Chinese medicine
Extract and immunopotentiator prevention mastitis for milk cows are increasingly concerned.Chinese medical extract and propolis are as natural
Drug, not only can be to avoid the public health problem that medicament residue is brought, but also is good immunomodulator.It is contained
Multiple biological activities ingredient, have antibacterial, anti-inflammatory, be not easy Induction of bacterial generate drug resistance, low toxicity, it is no or low residual etc. spies
Point, so exploitation is of great immediate significance and good prospect for preventing the Biological compound preparation of mastitis for milk cows.But
It is that current research dynamics is also far from enough, external research in this regard is almost blank, and domestic research is also mostly simple
It concentrates in the observation of some proved recipes and clinical efficacy.
Propolis is the resin that honeybee gathers from plant gemma or trunk, is mixed into the secretion of palatine gland, wax gland thereon
A kind of colloidal solid object with aromatic odor being process, with propolis solution is made after alcoholic extract.Recent studies is demonstrate,proved
It is bright, the abundant and unique bioactive substance contained by propolis, make it have antibacterial, anti-inflammatory and antalgic, detumescence, enhancing it is immune,
Promote the multiple functions such as cytothesis.
Notoginsenoside R derives from the drying root and rhizome of Radix Notoginseng Panax notoginseng (Burk.) F.H.Chen, tool
There are the functions such as dissipate stasis of blood hemostasis, detumescence ding-tong, moreover it is possible to promote the biosynthesis of DNA and protein, improve the immunocompetence of body.
Astragalus polyose is the water that the extracted dry root of legume astragalus mongolicus or Astragalus membranacus, concentration, purifying form
Dissolubility heteroglycan.Faint yellow, powder is fine and smooth, uniform free from admixture, and tool draws moist.Astragalus polyose is by hexuronic acid, glucose, fruit
The compositions such as sugar, rhamnose, arabinose, galacturonic acid and glucuronic acid can be used as immunopotentiating agent or conditioning agent, together
When there is antiviral, antitumor, anti-aging, radioresistance, resisting stress, anti-oxidant.
The content of the invention
In order to solve the above technical problems, an embodiment of the present invention provides a kind of compound systems of biology for preventing mastitis for milk cows
Agent includes following component in Biological compound preparation described in per 100ml：
Further, described in every 100ml following component is included in Biological compound preparation：
Preferably, described in every 100ml following component is included in Biological compound preparation：
Wherein, the Biological compound preparation of the prevention mastitis for milk cows is a kind of breast injection, is hydrogel.
The embodiment of the present invention additionally provides a kind of preparation method of the Biological compound preparation of above-mentioned prevention mastitis for milk cows, bag
Include following steps：
(1) propolis solution is prepared：Propolis powder 5g is taken, is put in 100ml flasks, adds ethyl alcohol 50ml, stirring, cold soaking 24 are small
When, it is filtered with the filter paper weighed.Insoluble object is washed with a small amount of ethyl alcohol twice, after insoluble matter and 45 DEG C of dryings of filter paper, is claimed
Weight, calculates propolis ethanol soluble extraction content, and >=50% side can apply.
(2) 50ml sterile water for injection is taken, is placed in sterile chamber；
(3) propolis solution of step (1) recipe quantity is taken, is added in the sterile water for injection of step (2), is stirred, dissolving；
(4) notoginsenoside R of recipe quantity is taken, is added in step (3) acquired solution, is stirred, dissolving；
(5) astragalus polyose of recipe quantity is taken, is added in step (4) acquired solution, is stirred, dissolving；
(6) glycerine of recipe quantity is taken, is added in step (5) acquired solution, is stirred, dissolving；
(7) sodium chloride of recipe quantity is taken, is added in step (6) acquired solution, is stirred, dissolving；
(8) by the Sodium Hyaluronate of recipe quantity, it is added in step (7) acquired solution, stirs, dissolving；
(9) with sterile water for injection by step (8) acquired solution constant volume to 100ml, stirring is mixed into hydrogel；
(10) by hydrogel obtained by step (9), it is dispensed into 10ml sterile centrifugation tubes, seals to get prevention cow breast
Scorching Biological compound preparation.
The above-mentioned technical proposal of the present invention has the beneficial effect that：The present invention was used to prevent and treat milk cow's milk in the dry milk phase
The breast injection of adenositis is the Biological compound preparation of hydrogel.The biomaterial preparation can effectively prevent dairy cattle during nonlactating
Mammitis can also coordinate treatment of the other medicines for clinical mammitis and recessive mastitis, can reduce body cell, shortening
Treatment cycle improves the cure rate of mammitis.
Specific embodiment
To make the technical problem to be solved in the present invention, technical solution and advantage clearer, below in conjunction with specific implementation
Example is described in detail.
An embodiment of the present invention provides a kind of Biological compound preparations for preventing mastitis for milk cows, and biology is multiple described in per 100ml
It closes and following component is included in preparation：
Further, described in every 100ml following component is included in Biological compound preparation：
Preferably, described in every 100ml following component is included in Biological compound preparation：
Wherein, the Biological compound preparation of the prevention mastitis for milk cows is a kind of breast injection, is hydrogel.It should
Injectant is administered when the dry milk phase starts, and can effectively prevent mammitis of dairy cattle during nonlactating.
The present invention also provides a kind of preparation method of the Biological compound preparation of above-mentioned prevention mastitis for milk cows, including as follows
Step：
(1) propolis solution is prepared：Propolis powder 5g is taken, is put in 100ml flasks, adds ethyl alcohol 50ml, stirring, cold soaking 24 are small
When, it is filtered with the filter paper weighed.Insoluble object is washed with a small amount of ethyl alcohol twice, after insoluble matter and 45 DEG C of dryings of filter paper, is claimed
Weight, calculates propolis ethanol soluble extraction content, and >=50% side can apply.
(2) 50ml sterile water for injection is taken, is placed in sterile chamber；
(3) propolis solution of step (1) recipe quantity is taken, is added in the sterile water for injection of step (2), is stirred, dissolving；
(4) notoginsenoside R of recipe quantity is taken, is added in step (3) acquired solution, is stirred, dissolving；
(5) astragalus polyose of recipe quantity is taken, is added in step (4) acquired solution, is stirred, dissolving；
(6) glycerine of recipe quantity is taken, is added in step (5) acquired solution, is stirred, dissolving；
(7) sodium chloride of recipe quantity is taken, is added in step (6) acquired solution, is stirred, dissolving；
(8) by the Sodium Hyaluronate of recipe quantity, it is added in step (7) acquired solution, stirs, dissolving；
(9) with sterile water for injection by step (8) acquired solution constant volume to 100ml, stirring is mixed into hydrogel；
(10) by hydrogel obtained by step (9), it is dispensed into 10ml sterile centrifugation tubes, seals to get prevention cow breast
Scorching Biological compound preparation.
The technical solution further illustrated the present invention below with several specific embodiments and experimental result.
Embodiment 1
(1) propolis solution is prepared：Propolis powder 5g is taken, is put in 100ml flasks, adds ethyl alcohol 50ml, stirring, cold soaking 24 are small
When, it is filtered with the filter paper weighed.Insoluble object is washed with a small amount of ethyl alcohol twice, after insoluble matter and 45 DEG C of dryings of filter paper, is claimed
Weight, calculates propolis ethanol soluble extraction content, and >=50% side can apply.
(2) 50ml sterile water for injection is taken, is placed in sterile chamber；
(3) step (1) 15ml propolis solutions are taken, are added in the sterile water for injection of step (2), are stirred, dissolving；
(4) 3g notoginsenoside Rs are taken, are added in step (3) acquired solution, are stirred, dissolving；
(5) 5g astragalus polyoses are taken, are added in step (4) acquired solution, are stirred, dissolving；
(6) 5ml glycerine is taken, is added in step (5) acquired solution, is stirred, dissolving；
(7) 0.9g sodium chloride is taken, is added in step (6) acquired solution, is stirred, dissolving；
(8) by 1g Sodium Hyaluronates, it is added in step (7) acquired solution, stirs, dissolving；
(9) with sterile water for injection by step (8) acquired solution constant volume to 100ml, stirring is mixed into hydrogel；
(10) by hydrogel obtained by step (9), it is dispensed into 10ml sterile centrifugation tubes, seals to get prevention cow breast
Scorching Biological compound preparation sample 1.
Embodiment 2
According to the preparation process and flow of embodiment 1, sample 2 and 3 is prepared.Wherein, the component of sample 2 and 3 and proportioning are shown in
The following table 1.
1 sample 2 of table, 3 prescription contents
Embodiment 3
2 gained sample 1,2 and 3 of Example 1 and embodiment, certain scale pasture dry milk phase milk cow 120 are divided into four
Group, every group 30.First group of milk cow, first to each newborn area's injection 3ml sample A1, then reinjects dry milk pin in dry milk；The
Two groups of milk cows, first to each newborn area's injection 3ml sample A2, then reinject dry milk pin in dry milk；3rd group of milk cow is in dry milk
When, first to each newborn area's injection 3ml sample A3, then reinject dry milk pin.4th group is control group, is first noted to each newborn area
Enter 0.9% physiological saline of 3ml, then reinject dry milk pin.To during calving, counting mammitis and the stealth that every group of milk cow occurs
The quantity of mammitis.As a result such as the following table 2.
2 mastitis for milk cows incidence of table
| Group | Test milk cow number (head) | Recessive mastitis incidence (%) | Clinical incidence of mammits (%) | Total (%) |
| Sample 1 | 30 | 3.33(1/30) | (0/30) | 3.33(1/30) |
| Sample 2 | 30 | 10(3/30) | 6.67(2/30) | 16.67(5/30) |
| Sample 3 | 30 | 6.67(2/30) | 3.33(1/30) | 13.33(4/30) |
| Control group | 30 | 20(6/30) | 16.67(5/30) | 36.37(11/30) |
It carries out the milk cow of dry milk after injection sample 1,2 and 3 again it can be seen from upper table data, occurs in the dry milk phase clinical
The incidence of type mammitis and recessive mastitis is significantly lower than the milk cow that this product is not used, wherein being sent out using the milk cow of sample 1
Raw rate is minimum, and effect is best.Illustrate that product of the present invention is used before dry milk, can be good at preventing mammitis of dairy cattle during nonlactating
Incidence.
Embodiment 4
Clinic mastitis milk cow 80 is suffered from 2 gained sample 1,2 and 3 of Example 1 and embodiment, certain scale pasture,
Mammitis grading is two level, is equally divided into four groups, every group 20.First group of illness milk cow is terminated in daily last time milking
Afterwards, to each newborn area injection 4ml samples 1, other therapeutic schemes are the same as control group milk cow；Second group of illness milk cow is last daily
After once milking, to each newborn area injection 4ml samples 2, other therapeutic schemes are the same as control group milk cow；3rd group of illness milk
Ox is after daily last time is milked, and to each newborn area's injection 4ml samples A3, other therapeutic schemes are the same as control group milk cow；
4th group is control group, and diseased milk cow is after daily last time is milked, to each newborn area's injection 0.9% physiology salts of 3ml
Water is treated according to pasture therapeutic scheme.Count the cure rate in every group of illness milk cow one week.As a result such as the following table 3.
3 mastitis for milk cows of table controls cure rate
| Group | Test milk cow number (head) | Mammitis cure rate (%) |
| Sample 1 | 20 | 75(15/20) |
| Sample 2 | 20 | 50(10/20) |
| Sample 3 | 20 | 60(12/20) |
| Control group | 20 | 30(6/20) |
Sample 1,2 and 3 is used over the course for the treatment of with secondary clinical mammitis milk cow it can be seen from upper table data,
More untapped illness milk cow, the cure rate in one week significantly improve.Therefore, can substantially reduce the treatment of diseased milk cow into
Originally and milk cost is abandoned.Day highest wherein is cured using the diseased milk cow of sample 1, effect is best.Illustrate product of the present invention for
There is positive effect in terms for the treatment of milk cow clinic mastitis, cure rate can be improved, reduce treatment cost.
Claims (5)
- A kind of 1. Biological compound preparation for preventing mastitis for milk cows, which is characterized in that bag in Biological compound preparation described in per 100ml Containing following component：
- 2. the Biological compound preparation of prevention mastitis for milk cows according to claim 1, which is characterized in that described in per 100ml Following component is included in Biological compound preparation：
- 3. the Biological compound preparation of prevention mastitis for milk cows according to claim 1 or 2, which is characterized in that per 100ml institutes It states in Biological compound preparation comprising following component：
- 4. the Biological compound preparation of prevention mastitis for milk cows according to claim 1 or 2, which is characterized in that the biology Compound formulation is a kind of breast injection, is hydrogel.
- 5. the preparation method of the biomaterial preparation such as prevention mastitis for milk cows according to any one of claims 1 to 4, special Sign is, includes the following steps：(1) propolis solution is prepared：Propolis powder 5g is taken, is put in 100ml flasks, adds ethyl alcohol 50ml, when stirring, cold soaking 24 are small, is used The filter paper filtration weighed.Insoluble object is washed with a small amount of ethyl alcohol twice, after insoluble matter and 45 DEG C of dryings of filter paper, is weighed, and is counted Propolis ethanol soluble extraction content is calculated, >=50% side can apply.(2) 50ml sterile water for injection is taken, is placed in sterile chamber；(3) propolis solution of step (1) recipe quantity is taken, is added in the sterile water for injection of step (2), is stirred, dissolving；(4) notoginsenoside R of recipe quantity is taken, is added in step (3) acquired solution, is stirred, dissolving；(5) astragalus polyose of recipe quantity is taken, is added in step (4) acquired solution, is stirred, dissolving；(6) glycerine of recipe quantity is taken, is added in step (5) acquired solution, is stirred, dissolving；(7) sodium chloride of recipe quantity is taken, is added in step (6) acquired solution, is stirred, dissolving；(8) by the Sodium Hyaluronate of recipe quantity, it is added in step (7) acquired solution, stirs, dissolving；(9) with sterile water for injection by step (8) acquired solution constant volume to 100ml, stirring is mixed into hydrogel；(10) by hydrogel obtained by step (9), it is dispensed into 10ml sterile centrifugation tubes, seals to get prevention mastitis for milk cows Biological compound preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711203037.4A CN108096284A (en) | 2017-11-20 | 2017-11-20 | A kind of Biological compound preparation for preventing mastitis for milk cows and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711203037.4A CN108096284A (en) | 2017-11-20 | 2017-11-20 | A kind of Biological compound preparation for preventing mastitis for milk cows and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108096284A true CN108096284A (en) | 2018-06-01 |
Family
ID=62208540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711203037.4A Pending CN108096284A (en) | 2017-11-20 | 2017-11-20 | A kind of Biological compound preparation for preventing mastitis for milk cows and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108096284A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068684A (en) * | 2011-01-21 | 2011-05-25 | 河南亚卫动物药业有限公司 | Perfusate and preparation method thereof for treating cow recessive mastitis |
| CN106727720A (en) * | 2016-12-13 | 2017-05-31 | 四川喜亚动物药业有限公司 | A kind of medicine for garget and preparation method thereof |
| CN106975073A (en) * | 2017-04-07 | 2017-07-25 | 南通大学 | Prevent and treat biomaterial preparation of mastitis for milk cows and preparation method thereof |
-
2017
- 2017-11-20 CN CN201711203037.4A patent/CN108096284A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068684A (en) * | 2011-01-21 | 2011-05-25 | 河南亚卫动物药业有限公司 | Perfusate and preparation method thereof for treating cow recessive mastitis |
| CN106727720A (en) * | 2016-12-13 | 2017-05-31 | 四川喜亚动物药业有限公司 | A kind of medicine for garget and preparation method thereof |
| CN106975073A (en) * | 2017-04-07 | 2017-07-25 | 南通大学 | Prevent and treat biomaterial preparation of mastitis for milk cows and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 丁伯良等: "《奶牛乳房炎》", 31 January 2011, 中国农业出版社 * |
| 张须学: "《天然药物化学》", 30 September 2012, 西安交通大学出版社 * |
| 王明俊等: "《兽医生物制品学》", 31 July 1997, 中国农业出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103462881B (en) | A kind of composition and method of making the same promoting skin microecological balance | |
| CN104873462B (en) | A kind of milch cow dry breast phase Cefquinome sulfate breast injection and preparation method thereof | |
| CN103800661B (en) | A kind of enhancing immunity, alleviating physical fatigue compositions and containing its preparation | |
| CN104161181A (en) | Feed additive for preventing pig bacterial diseases, preparation method and application thereof | |
| CN102579597A (en) | Chinese herbal compound prescription for preventing and curing mammitis of mammalian livestock and method for preparing same | |
| CN103816209A (en) | Eu-commin intragastric administration agent for cows and preparation method thereof | |
| RU2706689C1 (en) | Method for treating mastitis in cows | |
| CN104938822A (en) | Feed additive for reducing cow body cells and treating recessive mastitis and preparation method of feed additive | |
| CN104161208A (en) | Feed additive for preventing chicken bacterial diseases, preparation method and application thereof | |
| CN108096284A (en) | A kind of Biological compound preparation for preventing mastitis for milk cows and preparation method thereof | |
| CN106389477B (en) | A kind of preparation method and application of the full cellular plant oil extract of Gordonia terrae | |
| CN108850541A (en) | A kind of feed addictive and preparation method thereof of the alternative antibiotic of disease preventing and treating | |
| CN105558350A (en) | Feed containing Chinese herbal medicine compound crude polysaccharide and preparation method of feed | |
| CN101642475A (en) | Microbial preparation for preventing and treating mastitis and applications thereof | |
| CN101574355B (en) | Compound antibacterial injection for livestock and preparation method thereof | |
| CN103920041A (en) | Chinese veterinary medicine composition for tonifying qi, nourishing blood, restoring menstrual flow and promoting lactation, and preparation method and application thereof | |
| CN104800525A (en) | Medicine for preventing and treating pig diarrhoea | |
| CN108740433A (en) | A kind of Chinese herbal feed additive for three inflammation and mastitis for milk cows of sow postpartum | |
| CN105012399A (en) | Chinese medicine film agent used for treating recessive mastitis of dairy cows and preparation method thereof | |
| CN111544570B (en) | Antiviral preparation added with antibacterial peptide and preparation method thereof | |
| CN111000974B (en) | Rabbit milk active small peptide solution and extraction method and application thereof | |
| CN103285079B (en) | Preparation process of perfusion agent for treating dairy cow mastitis | |
| CN102139015B (en) | Medicinal liquor capable of balancing yin and yang and improving immunity and preparation thereof | |
| CN106860857A (en) | A kind of chinese-western medicine preparation for treating the yellowish-white dysentery of pig | |
| CN101116504B (en) | Health products for reducing blood fat and method for preparing the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180601 |
|
| WD01 | Invention patent application deemed withdrawn after publication |