CN106727628A - A kind of Western medicine compound for treating chronic diarrhea - Google Patents
A kind of Western medicine compound for treating chronic diarrhea Download PDFInfo
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- CN106727628A CN106727628A CN201611171791.XA CN201611171791A CN106727628A CN 106727628 A CN106727628 A CN 106727628A CN 201611171791 A CN201611171791 A CN 201611171791A CN 106727628 A CN106727628 A CN 106727628A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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Abstract
The invention discloses a kind of Western medicine compound for treating chronic diarrhea, the Western medicine compound of the treatment chronic diarrhea is according to the primary raw material of weight portion：22 27 parts of paeonilactone A, 58 parts of paeonoside, 19 30 parts of oxypeucedanin, 7 20 parts of hederin H, 5 10 parts of perilla alcohol, 34 parts of dichotomitin, 6 ", 0.5 1.3 parts of malonic acid complanatoside monoesters, 5 10 parts of Neoliquiritin, 36 parts of moleplant seed sterol, 24 parts of L histidine hydrochlorides.Medicine of the present invention is strictly selected material composition according to the understanding mechanism of chronic diarrhea, so as to reach the purpose of comprehensive rehabilitation, with rapid-action, effect stabilization, carry convenient to take, long-term taking and have no toxic side effect the characteristics of.
Description
Technical field
The present invention relates to a kind of field of medicine preparation, specifically a kind of Western medicine compound for treating chronic diarrhea.
Background technology
Diarrhoea is a kind of common clinical symptoms, means daily defecation frequency more than 3 times, or moisture increase is led in excrement
Cause excrement matter thin, or daily feces volume is more than 200g, or containing not digesting food or purulence blood.Chronic diarrhea refer to the course of disease two months with
On diarrhoea or intermittent phase in 2-4 weeks recurrent diarrhoea.Diarrhoea reason is a lot, and content flows into enteric cavity etc. after gastrectomy
Diarrhoea can be caused, other such as chronic pancreatitis, enteron aisle alactasia, intestinal mucosa lesion in itself also can be because of absorbability
Go down and cause diarrhoea.With the improvement of people ' s living standards and living-pattern preservation, the incidence of disease is in the trend for rising year by year, hair
The incidence of disease up to country is far above developing country, and the city incidence of disease is higher than rural area, and the good regional incidence of disease of economic condition is higher than
The remote mountain areas for falling relatively.Chronic diarrhea, it is touching repeatedly, the course of disease is up to some months, several years, or even many decades, clinical manifestation
Diarrhoea, loose watery stool, color is yellowish several times within one day, just many foams, and foul smell is lighter, borborygmus stomachache, serious appearance bloody stool, purulence
Bloody stool, while with heating, weak, essence of becoming thin is dispirited, has a strong impact on patient and normally learns, works and live.
For chronic diarrhea, enteritis, doctor trained in Western medicine is considered that enteron aisle inwall is contaminted for a long time and do not heal that intestinal mucosa tissue is damaged,
Chronic ulcer, remaining mucosal epithelium denaturation, mucous membrane hypodermis oedema and a series of pathological changes are formed, chronic diarrhea is caused, its medicine
Thing typically uses antibiotic, such as berberine, norfloxacin norfloxacin, willow nitrogen Huang amine pyridine, corticosteroid hormone and immune suppression
Preparation, but curative effect is undesirable, easily recurrence, and take medicine for a long time, side effect is big.Such as Semen daturae tablet, the cholinolytic Western medicine such as atropine, pair
Dry after clothes is act as, eye is done, have palpitation etc., the elderly's Yi Yinqi retention of urines；Using bismuth subcarbonate, the intestinal mucosa such as tannalbin is protected
Shield medicament, easy acid regurgitation water, easily causes digestive discomfort after clothes；Take compound diphenoxylate, loperamide etc. and suppress enterocinesia west
Medicine, easily causes the side effects such as abdominal distension, indigestion, constipation.Western medicine curative effect is undesirable, and has side effect, this be many people all
Know.
Therefore, it is badly in need of a kind of suitable good effect of research and development, speed is fast, price is low, the Western medicine compound that has no toxic side effect.
The content of the invention
It is an object of the invention to provide a kind of Western medicine compound for treating chronic diarrhea, with solving above-mentioned background technology
The problem of proposition.
To achieve the above object, the present invention provides following technical scheme：
A kind of Western medicine compound for treating chronic diarrhea, be according to the primary raw material of weight portion：Paeonilactone A 22-27
Part, paeonoside 5-8 parts, oxypeucedanin 19-30 parts, 7-20 parts of hederin H, perilla alcohol 5-10 parts, dichotomitin 3-4
Part, 6 " -0.5-1.3 parts of malonic acid complanatoside monoesters, Neoliquiritin 5-10 parts, moleplant seed sterol 3-6 parts, L-Histidine hydrochloric acid
Salt 2-4 parts.
As further scheme of the invention：The Western medicine compound of the treatment chronic diarrhea, according to the main of weight portion
Raw material is：Paeonilactone A 23-25 parts, paeonoside 6-7 parts, oxypeucedanin 22-27 parts, it is 9-13 parts of hederin H, purple
Soviet Union 6-8 parts of alcohol, dichotomitin 3-4 parts, 6 " -0.8-1.2 parts of malonic acid complanatoside monoesters, Neoliquiritin 6-8 parts, moleplant seed steroid
Alcohol 3-6 parts, 2-4 parts of L-Histidine hydrochloride.
As further scheme of the invention：The Western medicine compound of the treatment chronic diarrhea, according to the main of weight portion
Raw material is：It is 24 parts of paeonilactone A, 7 parts of paeonoside, 25 parts of oxypeucedanin, 11 parts of hederin H, 7 parts of perilla alcohol, white
4 parts of blackberry lily element, 6 " -1.0 parts of malonic acid complanatoside monoesters, 7 parts of Neoliquiritin, 5 parts of moleplant seed sterol, L-Histidine hydrochloride
3 parts.
A kind of preparation method of the Western medicine compound for treating chronic diarrhea, concretely comprises the following steps：
First, in pharmaceutical grade clean area, by above-mentioned metering ratio weigh paeonilactone A, paeonoside, oxypeucedanin,
Hederin H, perilla alcohol, dichotomitin, 6 "-malonic acid complanatoside monoesters, Neoliquiritin, moleplant seed sterol, L-Histidine
Hydrochloride, sieving, machinery adds ultra-pure water after mixing, place in pharmacy mixer, mixes 4-8min, controls RSD≤5%, mixes
Compressing tablet and low temperature drying after conjunction, at 4-8 DEG C, packaging obtains final product the Western medicine compound for the treatment of chronic diarrhea to temperature control.
As further scheme of the invention：Mix 6min in specific steps.
As further scheme of the invention：Temperature control is at 6 DEG C in specific steps.
Compared with prior art, the beneficial effects of the invention are as follows：
Medicine of the present invention is strictly selected material composition according to the understanding mechanism of chronic diarrhea, so as to reach comprehensive health
Multiple purpose, with rapid-action, effect stabilization, carry convenient to take, long-term taking and have no toxic side effect the characteristics of.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of Western medicine compound for treating chronic diarrhea, be according to the primary raw material of weight portion：It is 22 parts of paeonilactone A, male
5 parts of red phenolic glycoside, 19 parts of oxypeucedanin, 7 parts of hederin H, 5 parts of perilla alcohol, 3 parts of dichotomitin, 6 "-malonic acid semen astragali complanati
0.5 part of glycosides monoesters, 5 parts of Neoliquiritin, 3 parts of moleplant seed sterol, 2 parts of L-Histidine hydrochloride.
A kind of preparation method of the Western medicine compound for treating chronic diarrhea, concretely comprises the following steps：
First, in pharmaceutical grade clean area, by above-mentioned metering ratio weigh paeonilactone A, paeonoside, oxypeucedanin,
Hederin H, perilla alcohol, dichotomitin, 6 "-malonic acid complanatoside monoesters, Neoliquiritin, moleplant seed sterol, L-Histidine
Hydrochloride, sieving, machinery adds ultra-pure water after mixing, place in pharmacy mixer, mixes 4min, controls RSD≤5%, mixing
Compressing tablet and low temperature drying afterwards, at 4 DEG C, packaging obtains final product the Western medicine compound for the treatment of chronic diarrhea to temperature control.
Embodiment 2
A kind of Western medicine compound for treating chronic diarrhea, be according to the primary raw material of weight portion：It is 23 parts of paeonilactone A, male
6 parts of red phenolic glycoside, 22 parts of oxypeucedanin, 9 parts of hederin H, 6 parts of perilla alcohol, 3 parts of dichotomitin, 6 "-malonic acid semen astragali complanati
0.8 part of glycosides monoesters, 6 parts of Neoliquiritin, 3 parts of moleplant seed sterol, 2 parts of L-Histidine hydrochloride.
A kind of preparation method of the Western medicine compound for treating chronic diarrhea, concretely comprises the following steps：
First, in pharmaceutical grade clean area, by above-mentioned metering ratio weigh paeonilactone A, paeonoside, oxypeucedanin,
Hederin H, perilla alcohol, dichotomitin, 6 "-malonic acid complanatoside monoesters, Neoliquiritin, moleplant seed sterol, L-Histidine
Hydrochloride, sieving, machinery adds ultra-pure water after mixing, place in pharmacy mixer, mixes 4min, controls RSD≤5%, mixing
Compressing tablet and low temperature drying afterwards, at 4 DEG C, packaging obtains final product the Western medicine compound for the treatment of chronic diarrhea to temperature control.
Embodiment 3
A kind of Western medicine compound for treating chronic diarrhea, be according to the primary raw material of weight portion：It is 24 parts of paeonilactone A, male
7 parts of red phenolic glycoside, 25 parts of oxypeucedanin, 11 parts of hederin H, 7 parts of perilla alcohol, 4 parts of dichotomitin, 6 "-malonic acid semen astragali complanati
1.0 parts of glycosides monoesters, 7 parts of Neoliquiritin, 5 parts of moleplant seed sterol, 3 parts of L-Histidine hydrochloride.
A kind of preparation method of the Western medicine compound for treating chronic diarrhea, concretely comprises the following steps：
First, in pharmaceutical grade clean area, by above-mentioned metering ratio weigh paeonilactone A, paeonoside, oxypeucedanin,
Hederin H, perilla alcohol, dichotomitin, 6 "-malonic acid complanatoside monoesters, Neoliquiritin, moleplant seed sterol, L-Histidine
Hydrochloride, sieving, machinery adds ultra-pure water after mixing, place in pharmacy mixer, mixes 6min, controls RSD≤5%, mixing
Compressing tablet and low temperature drying afterwards, at 6 DEG C, packaging obtains final product the Western medicine compound for the treatment of chronic diarrhea to temperature control.
Embodiment 4
A kind of Western medicine compound for treating chronic diarrhea, be according to the primary raw material of weight portion：It is 25 parts of paeonilactone A, male
7 parts of red phenolic glycoside, 27 parts of oxypeucedanin, 13 parts of hederin H, 8 parts of perilla alcohol, 4 parts of dichotomitin, 6 "-malonic acid semen astragali complanati
1.2 parts of glycosides monoesters, 8 parts of Neoliquiritin, 6 parts of moleplant seed sterol, 4 parts of L-Histidine hydrochloride.
A kind of preparation method of the Western medicine compound for treating chronic diarrhea, concretely comprises the following steps：
First, in pharmaceutical grade clean area, by above-mentioned metering ratio weigh paeonilactone A, paeonoside, oxypeucedanin,
Hederin H, perilla alcohol, dichotomitin, 6 "-malonic acid complanatoside monoesters, Neoliquiritin, moleplant seed sterol, L-Histidine
Hydrochloride, sieving, machinery adds ultra-pure water after mixing, place in pharmacy mixer, mixes 8min, controls RSD≤5%, mixing
Compressing tablet and low temperature drying afterwards, at 8 DEG C, packaging obtains final product the Western medicine compound for the treatment of chronic diarrhea to temperature control.
Embodiment 5
A kind of Western medicine compound for treating chronic diarrhea, be according to the primary raw material of weight portion：It is 27 parts of paeonilactone A, male
8 parts of red phenolic glycoside, 30 parts of oxypeucedanin, 20 parts of hederin H, 10 parts of perilla alcohol, 4 parts of dichotomitin, 6 "-malonic acid sand garden
1.3 parts of sub- glycosides monoesters, 10 parts of Neoliquiritin, 6 parts of moleplant seed sterol, 4 parts of L-Histidine hydrochloride.
A kind of preparation method of the Western medicine compound for treating chronic diarrhea, concretely comprises the following steps：
First, in pharmaceutical grade clean area, by above-mentioned metering ratio weigh paeonilactone A, paeonoside, oxypeucedanin,
Hederin H, perilla alcohol, dichotomitin, 6 "-malonic acid complanatoside monoesters, Neoliquiritin, moleplant seed sterol, L-Histidine
Hydrochloride, sieving, machinery adds ultra-pure water after mixing, place in pharmacy mixer, mixes 8min, controls RSD≤5%, mixing
Compressing tablet and low temperature drying afterwards, at 8 DEG C, packaging obtains final product the Western medicine compound for the treatment of chronic diarrhea to temperature control.
Pharmacology test
1st, acute toxicity test
It is experiment with Western medicine compound obtained in the embodiment of the present invention 3, using gastric infusion mode, is continuously given in 24h
Medicine 2 times, per minor tick 12h, is administered 200mg/kg doses every time, and daily accumulation medicine total amount reaches 400mg medicines/kg, equivalent to
80 times of people's quantity.After administration in 7d, mouse activity, feed, excretion are normal, well-grown, hair color light, and its is average
Body weight increases with the extension of experimental period.Every mouse of post mortem at 8d, visually observe the heart, liver, spleen, lung, kidney,
Brain, thymus gland, stomach, intestines etc. do not find color and paramophia, fail to measure median lethal dose (LD50).Result shows：This hair
Bright Western medicine compound is without acute toxic reaction.
2nd, long term toxicity test
It is experiment with Western medicine compound obtained in the embodiment of the present invention 3, using gastric infusion mode, by Western medicine group of the present invention
Compound is divided into low dosage, middle dosage, three groups of high dose, the drug dose of each group is respectively 50,100,150mg medicines/kg/d, phase
When in 10,20,30 times of clinical dosage.After gastric infusion 24 weeks, medicine of the present invention refers to the general status of animal, hematology
Mark, blood parameters without obvious influence, Systematic anatomy, organ coefficient and histopathological examination also no abnormal disease
Reason changes.It is discontinued 2 weeks and also has no substantially change.Result shows：Western medicine compound of the present invention does not find in long term toxicity test
Overt toxicity reacts and delayed toxicity reaction.It can be seen that, Western medicine compound non-toxic reaction of the present invention, long-term prescription is safe and reliable.
3rd, clinical test
Diagnostic criteria：Defecation frequency is significantly more than the frequency being accustomed on ordinary days, and excrement matter is thin, daily Fecal wastes more than 200g,
Or containing not digesting food or purulence blood, and recurrent diarrhoea of diarrhoea or intermittent phase of the course of disease more than two months in 2-4 weeks is suffered from
Person.
Patient data：200 Chronic Diarrhea Patients, wherein male 113 are chosen, women 87 excludes gestation, renal function
Infull patient.
Treatment method：According to 5mg/kg/ days, 7 days was a course for the treatment of, carries out two treatments of the course for the treatment of.
The standard of curative effect evaluation：Cure：Patient's defecation is normal after treatment, and the symptom of diarrhoea is wholly absent, and true through doctor
Recognize and fully recovered；Effectively：Patient's defecation is normal, and defecation frequency still needs to continual cure close to the frequency being accustomed on ordinary days；Nothing
Effect：Patient's symptom of diarrhea even aggravate without taking a turn for the better；Recurrence：After healing in 6 months, same illness is suffered from.
Treatment results：200 patients, 174 healings, 15 are effectively, and 11 are invalid, total effective rate 94.5%.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be in other specific forms realized.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires to be limited rather than described above, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each implementation method is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should
Specification an as entirety, the technical scheme in each embodiment can also be formed into those skilled in the art through appropriately combined
May be appreciated other embodiment.
Claims (6)
1. a kind of Western medicine compound for treating chronic diarrhea, it is characterised in that the primary raw material according to weight portion is：Peony lactone
A 22-27 parts, paeonoside 5-8 parts, oxypeucedanin 19-30 parts, 7-20 parts of hederin H, perilla alcohol 5-10 parts, penetrate in vain
Dry 3-4 parts of element, 6 " -0.5-1.3 parts of malonic acid complanatoside monoesters, Neoliquiritin 5-10 parts, moleplant seed sterol 3-6 parts, L- groups
2-4 parts of propylhomoserin hydrochloride.
2. it is according to claim 1 treatment chronic diarrhea Western medicine compound, it is characterised in that the treatment chronic diarrhea
Western medicine compound, be according to the primary raw material of weight portion：Paeonilactone A 23-25 parts, paeonoside 6-7 parts, the oxidation root of purple-flowered peucedanum
Plain 22-27 parts, 9-13 parts of hederin H, perilla alcohol 6-8 parts, dichotomitin 3-4 parts, 6 "-malonic acid complanatoside monoesters
0.8-1.2 parts, Neoliquiritin 6-8 parts, moleplant seed sterol 3-6 parts, 2-4 parts of L-Histidine hydrochloride.
3. it is according to claim 1 and 2 treatment chronic diarrhea Western medicine compound, it is characterised in that the treatment is chronic
The Western medicine compound of diarrhoea, be according to the primary raw material of weight portion：24 parts of paeonilactone A, 7 parts of paeonoside, oxypeucedanin
25 parts, 11 parts of hederin H, 7 parts of perilla alcohol, 4 parts of dichotomitin, 6 " -1.0 parts of malonic acid complanatoside monoesters, Neoliquiritin
7 parts, 5 parts of moleplant seed sterol, 3 parts of L-Histidine hydrochloride.
4. a kind of preparation method of the Western medicine compound for the treatment of chronic diarrhea as described in claim 1-3 is any, its feature exists
In concretely comprising the following steps：
First, in pharmaceutical grade clean area, paeonilactone A, paeonoside, oxypeucedanin, Chang Chun are weighed by above-mentioned metering ratio
Rattan glycosides H, perilla alcohol, dichotomitin, 6 "-malonic acid complanatoside monoesters, Neoliquiritin, moleplant seed sterol, L-Histidine hydrochloric acid
Salt, sieving, machinery adds ultra-pure water after mixing, place in pharmacy mixer, mixes 4-8min, RSD≤5% is controlled, after mixing
Compressing tablet and low temperature drying, at 4-8 DEG C, packaging obtains final product the Western medicine compound for the treatment of chronic diarrhea to temperature control.
5. the preparation method of the Western medicine compound for the treatment of chronic diarrhea according to claim 4, it is characterised in that specific step
Mixing 6min in rapid.
6. the preparation method of the Western medicine compound for the treatment of chronic diarrhea according to claim 4, it is characterised in that specific step
Temperature control is at 6 DEG C in rapid.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1608615A (en) * | 2003-10-17 | 2005-04-27 | 昆明紫健生物技术有限公司 | Fibrauretine-amino acid fluid for transfusion and its production process |
| CN102946876A (en) * | 2010-03-26 | 2013-02-27 | 切萨联盟有限公司 | Viral inhibitor compositions for in vivo therapeutic use comprising combination of (-) -carvone, geraniol and further essential oil component |
| WO2014165607A2 (en) * | 2013-04-02 | 2014-10-09 | Stealth Peptides International, Inc. | Aromatic-cationic peptide formulations, compositions and methods of use |
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Application publication date: 20170531 |