CN106720889A - A kind of betel nut shitosan chewing gum lozenge and preparation method and application - Google Patents
A kind of betel nut shitosan chewing gum lozenge and preparation method and application Download PDFInfo
- Publication number
- CN106720889A CN106720889A CN201710025752.7A CN201710025752A CN106720889A CN 106720889 A CN106720889 A CN 106720889A CN 201710025752 A CN201710025752 A CN 201710025752A CN 106720889 A CN106720889 A CN 106720889A
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- CN
- China
- Prior art keywords
- shitosan
- chewing gum
- betel nut
- gum lozenge
- lozenge
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- 239000007937 lozenge Substances 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title abstract description 16
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/068—Chewing gum characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/10—Chewing gum characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/18—Chewing gum characterised by shape, structure or physical form, e.g. aerated products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
- A23G2200/06—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents containing beet sugar or cane sugar if specifically mentioned or containing other carbohydrates, e.g. starches, gums, alcohol sugar, polysaccharides, dextrin or containing high or low amount of carbohydrate
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
- A23G2200/14—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents containing fruits, nuts, e.g. almonds, seeds, plants, plant extracts or essential oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to food processing technology field, and in particular to a kind of betel nut shitosan chewing gum lozenge, and its preparation method is further disclosed with application.Chewing gum lozenge of the present invention not only intactly remains the active component of fresh areca nuts with betelnut extract and shitosan as main component, the effect with protection oral mucosa and tooth；People are also solved to the demand of betel nut mouthfeel and the demand of betel nut nutrition crowd simultaneously；In addition, chewing gum lozenge addition shitosan of the present invention, is more conducive to remove oral cavity bacterium.
Description
Technical field
The invention belongs to food processing technology field, and in particular to a kind of betel nut shitosan chewing gum lozenge, and further
Open its preparation method and application.
Background technology
Fresh betel nut (Areca catechu L) is the ripening fruits of Palmae betel nut platymiscium betel nut, is precious Hainan
Tropical plants, first of the great Nan medicines of China 5 (betel nut, fructus amomi, intelligence development, Morinda offcinalis How, agalloch eaglewood).China is the main product ground of world's betel nut
One of, Hainan, the province of Taiwan two are mainly distributed on, current Hainan betel nut cultivated area and yield account for the 98% of China mainland.Betel nut
Equally liked by consumers in general deeply in China, betel quid chewing is that have more than the 2000 years traditional food custom of history, China
People is accustomed to betel quid chewing fresh fruit (Hainan, Taiwan) and dry fruit processed goods (other areas of China), is described as " the green arrow of China
Chewing gum ".Betel nut has arousing brain, raising spirit, the effect for producing floaty euphoria, improving endurance, is only second to nicotine, ethanol, coffee
The fourth-largest preference in the whole world, the current whole world there are about 700,000,000 people's edible areca-nuts, it is contemplated that 2,000,000,000 whole world consumption Bin will be formed after 10 years
Bulky crowd, annual value of production is expected to break through the trillion yuan of RMB 2.
In addition, betel nut also has abundant medical value, the nutrient that betel nut contains various needed by human body and has
Beneficial material, while also contain various pharmacological components, mainly including alkaloid, phenolic compound, fat oil and various ammonia
Sour and various mineral matter of base etc..Betel nut tradition effect have desinsection, disperse accumulations, Li Shui, help digestion, be depressured, the health care such as anticancer,
Medicinal function.Recent studies have found that the new effect of many betel nuts, such as antivirus action, anti-aging effect, reduce cholesterol and make
With, antidepressant effect, anti-senile dementia is antifatigue, enhancing body immunity the effects such as effect etc..
At present, betel nut is developed polytype product and puts goods on the market, such as Betelnut buccal tablet, areca-nut chewing gum, this
A little products are the demand for meeting people to betel nut mouthfeel, and instant edible.But on the one hand, the processing of existing betel nut product is
It is made using existing common process addition betel nut, is not developed targetedly according to betel nut product, furthermore, have for betel nut
The comprehensive utilization of beneficial composition is also slightly not enough.
The content of the invention
Therefore, the technical problems to be solved by the invention are to provide a kind of betel nut shitosan chewing gum lozenge, to solve
The betel nut product problem under-utilized to beneficiating ingredient in the prior art.
In order to solve the above technical problems, betel nut shitosan chewing gum lozenge of the present invention, with the chewing gum lozenge
Total amount meter, including following mass content raw material：
Betelnut extract 0.1-40wt%；
Shitosan 10-40wt%；
Auxiliary material surplus.
Preferably, described betel nut shitosan chewing gum lozenge, in terms of the total amount of the chewing gum lozenge, including following matter
Measure the raw material of content：
Betelnut extract 0.1-40wt%；
Shitosan 10-40wt%；
Cornstarch 10-20wt%；
Maltodextrin 20-40wt%；
Essence 1-10wt%；
Adhesive 5-20wt%；
Polyalcohol 0-20wt%.
The betelnut extract includes that mass ratio is 10-70：The total starches and total polyphenols of 5-30.
Preferably, in terms of the total amount of the betelnut extract, the mass percent of the total starches and total polyphenols is at least
15wt%.
More excellent, the betelnut extract extracts gained as follows：
(1) squeezing is extracted：Fresh betel nut is crushed and physical squeezing is carried out, collection fruit juice is separated by filtration, while merging residual
Slag is standby；
(2) residue is extracted：Add water mixing in residue, and adds the low-temperature cellulase to carry out biological cracking, then regulation
Reacting liquid pH value 2-7, filters to obtain extract solution；
(3) it is dehydrated：Gained fruit juice in gained extract solution and step (1) is merged to carry out dewater treatment and obtains solids, as
Required betelnut extract active component.
In the step (2), the addition of the low-temperature cellulase accounts for the 0.05%-1wt% of the residue weight, institute
The addition for stating water is the 3-10 times of weight amounts of the residue.
The polyalcohol includes the composition of one or more in xylitol, sorbierite, maltitol, lactitol.
Described adhesive is conventional use of edible glycerol in the prior art, edible gelatin, carboxymethylcellulose calcium, edible fruit
Glue etc..
The method of described betel nut shitosan chewing gum lozenge is prepared the invention also discloses a kind of, including is taken a selected amount of
Betelnut extract, shitosan, cornstarch, maltodextrin, essence, adhesive, polyalcohol, after grinding and preheating, mix
The step of obtaining mixed material；And by gained mixed material moulding by casting, the chewing gum lozenge is obtained final product after hanging.
The temperature of the preheating step is 40-60 DEG C, and the step temperature that hangs is for 5-10 DEG C.
It is used to prepare the purposes for the treatment of migraine remedy the invention also discloses described betel nut shitosan chewing gum lozenge.
Betel nut shitosan chewing gum lozenge of the present invention, with betelnut extract and shitosan as main component, wherein institute
It is to extract to prepare gained as raw material with fresh betel nut to state betelnut extract, further residual from betel nut with low temperature fiber element to extract enzyme
Extracted in slag and obtain total starches and total polyphenols composition, extract obtained active ingredient clearly, and active ingredient content
More than 15wt%, active component content is higher.
Shitosan (chitosan) is also called de- second phthalein chitin, is a kind of macromolecular that chitin decalcification takes off own phthalein
Chain cationic polysaccharide.The biological functionality and compatibility of this natural polymer, blood compatibility, security, microorganism drop
The premium properties such as solution property by all trades and professions extensive concern, medicine, food, chemical industry, cosmetics, water process, METAL EXTRACTION and time
The application study of the numerous areas such as receipts, biochemical and biomedical engineering achieves major progress.Chitin (chitin) is from first
The natural polysaecharides material extracted in shell class animal such as shrimp, the crust of crab.In nature, the biosynthesis amount of chitin is annual
About 10,000,000,000 t, are the reproducible organic resources of the second major class that cellulose is only second on the earth.Shitosan can prevent oral cavity from bursting
Ulcer, the activated immune factor, breed the Bifidobacterium of intestinal beneficial, suppress fat absorption, reduction blood fat and cholesterol, remove freely
Base toxin, suppression blood pressure rise, reduce blood sugar etc..
Chewing gum lozenge of the present invention not only intactly remains Bin with betelnut extract and shitosan as main component
The active component of bulky fresh fruit, the effect with protection oral mucosa and tooth；Also solve need of the people to betel nut mouthfeel simultaneously
Ask and betel nut nutrition crowd demand；In addition, chewing gum lozenge addition shitosan of the present invention, is more conducive to remove thin in oral cavity
Bacterium.
Pharmacological evaluation shows that in areca-nut chewing gum lozenge of the present invention, the betelnut extract can effectively facilitate brain blood
Liquid circulation, suppress 5-HT, pathogenic peptides and Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 isoreactivity, with activating blood circulation and dispersing blood clots, dredging collateral, alleviate angiospastic effect,
And platelet aggregation can be significantly inhibited, blood viscosity is reduced, so as to improve cerebral blood circulation and brain cell energetic supersession, protect
Brain cell, so that can effectively preventing antimigraine.Therefore, areca-nut chewing gum lozenge of the present invention has significant analgesia effect
Really, can effectively alleviate and treat cephalagra, and have the advantages that safe and free of toxic and side effects.
Specific embodiment
Authentication method：
First, using total starches content in spectrophotometry betelnut extract
Main agents and instrument：Glucose (biochemical reagents, National Institute for Food and Drugs Control)；5% phenol solution；It is dense
Sulfuric acid solution.DUV-2450 types ultraviolet-visible spectrophotometer (Japanese Shimadzu).1st, the preparation of standard solution
Precision weighs the glucose about 25mg of 105 DEG C of dryings to constant weight, is placed in 250mL volumetric flasks, after being dissolved in water, uses
Water is settled to scale, shakes up, concentration of glucose about 0.1mg/mL in the standard solution being made into.
2nd, prepared by betelnut extract (test sample) solution
Test sample about 50mg is taken, accurately weighed, the 40mL that adds water dissolvings are quantitatively transferred in 250mL volumetric flasks, are diluted with water
To scale.
3rd, assay method
3.1 standard curve determinations
Precision measures reference substance solution 0.2mL, 0.4mL, 0.6mL, 0.8mL, 1.0mL, puts respectively in tool plug test tube, distinguishes
Add water benefit to 2.0mL；
5% phenol solution 1mL of each accurate addition, shakes up, rapid accurate addition sulfuric acid 5mL, shakes up, and places 10min, puts 40
15min is incubated in DEG C water-bath, is taken out, be rapidly cooled to room temperature；
Blank solution is prepared simultaneously：Precision measures purified water 2mL, puts in tool plug test tube, and blank is prepared according to test sample method
Solution；
Returned to zero with blank solution, the mensuration absorbance at 490nm, with absorbance as ordinate, concentration is abscissa, is drawn
Regression curve, calculates equation of linear regression.
3.2 sample analysis
Precision measures need testing solution 0.5mL, puts in tool plug test tube, and add water benefit to 2.0mL.According under standard curve determination
Method prepare test sample and blank solution, with blank solution return to zero, the mensuration absorbance at 490nm.
4th, result is calculated
According to the equation of linear regression of glucose, the total starches concentration C in measured need testing solution is calculated2。
Total starches are with mass fraction w in betelnut extract2Meter, numerical value is represented with %, is calculated as follows：
The mass fraction of total starches component, % in w2- test samples；
C2Total starches concentration of component in-need testing solution, unit is mg/mL；
V2The dilution volume of-need testing solution, unit is milliliter (mL)；
m2The sample weighting amount of-test sample, unit is milligram (mg).
2nd, using total polyphenols in spectrophotometry betelnut extract
Main agents and instrument：Gallic acid (biochemical reagents, National Institute for Food and Drugs Control)；Methyl alcohol；7.5% carbon
Acid sodium solution；Forint phenol test solution；DUV-2450 types ultraviolet-visible spectrophotometer (Japanese Shimadzu).
1st, the preparation of standard solution
Gallic acid standard items about 20mg is taken, it is accurately weighed, it is transferred in 100mL volumetric flasks after being dissolved with methyl alcohol, plus first
Alcohol is settled to scale, shakes up, and obtains gallic acid storing solution.Precision measures above-mentioned storing solution 0.5,1,2,4,6,8,10mL, respectively
In putting 10mL volumetric flasks, plus methyl alcohol is to scale, shakes up, and obtains a series of gallic acid standard liquid of various concentrations.
2nd, prepared by betelnut extract (test sample) solution
Precision weighs test sample about 200-300mg, is transferred in 250mL volumetric flasks after methyl alcohol dissolving, with methanol constant volume extremely
Scale, shakes up and both obtained.
3rd, assay method
3.1 standard curve determinations
Precision measures the standard solution 0.2mL of above-mentioned each concentration, in putting 10mL nessler colorimetric tubes, plus distilled water 1mL, shake
It is even；
1.4mL films phenol reagent is added to add 1.8mL 0.9%NaNO immediately after acutely shaking3The aqueous solution acutely shakes again
Swing, shady place is placed 30 minutes；
Blank solution is prepared：Precision measures methyl alcohol 0.2mL, in putting 10mL nessler colorimetric tubes, plus distilled water 1mL, shake up, together
When prepare blank solution according to foregoing test sample method；
Returned to zero with blank solution, the mensuration absorbance at 730nm, with absorbance as ordinate, concentration is abscissa, is drawn
Regression curve, calculates equation of linear regression.
3.2 sample analysis
Precision draws 0.2mL need testing solutions, in putting 10mL nessler colorimetric tubes, plus distilled water 1mL, shaking up, sighting target is accurate bent
Line determines item lower section legal system available test product and blank solution, is returned to zero with blank solution, the mensuration absorbance at 730nm.
4th, result is calculated
According to the equation of linear regression of gallic acid, the polyphenol concentration C in measured need testing solution is calculated1。
Polyphenol is with mass fraction w in betelnut extract1Meter, numerical value is represented with %, is calculated as follows：
w1The mass fraction of weight polyphenol fraction, % in-test sample；
C1Weight polyphenol fraction concentration in-need testing solution, unit is mg/mL；
V1The dilution volume of-need testing solution, unit is milliliter (mL)；
m1The sample weighting amount of-test sample, unit is milligram (mg).
Preparation example 1
Betelnut extract is extracted in accordance with the following steps described in the present embodiment：
(1) squeezing is extracted：By the sorting of fresh betel nut, clean up, crush, at 50 DEG C, carry out squeezing with physical method and obtain
Fruit juice is obtained, fruit juice obtains clear juice by treatment, while it is stand-by to merge residue；
(2) residue is extracted：The water of the times of weight amount of residue weight 5 is added to mix in the residue of above-mentioned collection, while addition is accounted for
The low-temperature cellulase of the residue weight percentage 0.1wt% carries out biological cracking, and adds hydrochloric acid to adjust reacting liquid pH value
5, after standing 8h, 10000rpm centrifugations obtain extract solution；
(3) it is dehydrated：Gained fruit juice in combining step (2) gained extract solution and step (1), using low-temperature reduced-pressure condensing mode
It is dehydrated, is spray-dried to obtain solids, and crosses 60 mesh and crush, inspection is obtained final product required betelnut extract.
Detected according to foregoing detection method, total starches content is 50wt% in gained betelnut extract, Determination of Polyphenols is
10wt%.
Preparation example 2
Betelnut extract is extracted in accordance with the following steps described in the present embodiment：
(1) squeezing is extracted：By the sorting of fresh betel nut, clean up, crush, at 20 DEG C, carry out squeezing with physical method and obtain
Fruit juice is obtained, fruit juice obtains clear juice by treatment, while it is stand-by to merge residue；
(2) residue is extracted：The water of the times of weight amount of residue weight 3 is added to mix in the residue of above-mentioned collection, while addition is accounted for
The low-temperature cellulase of the residue weight percentage 0.05wt% carries out biological cracking, and adds hydrochloric acid to adjust reacting liquid pH value
2, after standing 12h, 6000rpm centrifugations obtain extract solution；
(3) it is dehydrated：Gained fruit juice in combining step (2) gained extract solution and step (1), using low-temperature reduced-pressure condensing mode
It is dehydrated, is spray-dried to obtain solids, and crosses 30-120 mesh and crush, inspection is obtained final product required betel nut active component.
Detected according to foregoing detection method, total starches content is 45wt% in gained betelnut extract, Determination of Polyphenols is
10wt%.
Preparation example 3
Betelnut extract is extracted in accordance with the following steps described in the present embodiment：
(1) squeezing is extracted：By the sorting of fresh betel nut, clean up, crush, at 80 DEG C, carry out squeezing with physical method and obtain
Fruit juice is obtained, fruit juice obtains clear juice by treatment, while it is stand-by to merge residue；
(2) residue is extracted：The water of the times of weight amount of residue weight 10 is added to mix in the residue of above-mentioned collection, while addition is accounted for
The low-temperature cellulase of the residue weight percentage 1wt% carries out biological cracking, and adds hydrochloric acid to adjust reacting liquid pH value 7,
After standing 1h, 12000rpm centrifugations obtain extract solution；
(3) it is dehydrated：Gained fruit juice in combining step (2) gained extract solution and step (1), using low-temperature reduced-pressure condensing mode
It is dehydrated, is spray-dried to obtain solids, and crosses 30-120 mesh and crush, inspection is obtained final product required betelnut extract.
Detected according to foregoing detection method, total starches content is 50wt% in gained betelnut extract, Determination of Polyphenols is
8wt%.
Embodiment 1
Take obtained betelnut extract 0.1kg, shitosan 30kg, cornstarch 20kg, maltodextrin in preparation example 1
30kg, essence 1.9kg, edible pectin 10kg, xylitol 8kg are mixed, and are ground and are crushed and cross 100 mesh sieve, are entered at 50 DEG C
Row is preheated, and then input mixer is stirred and is mixed into mixed material；The mixed material that will then obtain carries out moulding by casting,
Chewing gum lozenge is made after being hung at 5-10 DEG C.
Embodiment 2
Take obtained betelnut extract 1kg in preparation example 1, shitosan 30kg, cornstarch 20kg, maltodextrin 30kg,
Essence 2kg, edible pectin 9kg, xylitol 8kg are mixed, and are ground and are crushed 100 mesh sieve, are preheated at 50 DEG C, then
Input mixer is stirred and is mixed into mixed material；The mixed material that will be obtained carries out moulding by casting, after being hung at 5-10 DEG C
It is made chewing gum lozenge.
Embodiment 3
Take obtained betelnut extract 40kg in preparation example 2, shitosan 10kg, cornstarch 10kg, maltodextrin 20kg,
Essence 1kg, adhesive 5kg, maltitol 14kg are mixed, and are ground and are crushed 100 mesh sieve, are preheated at 50 DEG C, so
Input mixer is stirred and is mixed into mixed material afterwards；The mixed material that will be obtained carries out moulding by casting, is hung at 5-10 DEG C
It is made chewing gum lozenge afterwards.
Embodiment 4
Take obtained betelnut extract 5kg in preparation example 2, shitosan 40kg, cornstarch 15kg, maltodextrin 25kg,
Essence 5kg, adhesive 10kg are mixed, and are ground and are crushed 100 mesh sieve, are preheated at 50 DEG C, then put into mixer
It is stirred and is mixed into mixed material；The mixed material that will be obtained carries out moulding by casting, mouth is made after being hung at 5-10 DEG C fragrant
Sugared lozenge.
Embodiment 5
Take obtained betelnut extract 20kg in preparation example 3, shitosan 20kg, cornstarch 10kg, maltodextrin 20kg,
Essence 5kg, adhesive 20kg, sorbierite 5kg are mixed, and are ground and are crushed 100 mesh sieve, are preheated at 50 DEG C, then
Input mixer is stirred and is mixed into mixed material；The mixed material that will be obtained carries out moulding by casting, after being hung at 5-10 DEG C
It is made chewing gum lozenge.
Embodiment 6
Take obtained betelnut extract 10kg in preparation example 3, shitosan 10kg, cornstarch 10kg, maltodextrin 40kg,
Essence 1kg, adhesive 20kg, maltitol 9kg are mixed, and are ground and are crushed 100 mesh sieve, are preheated at 50 DEG C, so
Input mixer is stirred and is mixed into mixed material afterwards；The mixed material that will be obtained carries out moulding by casting, is hung at 5-10 DEG C
It is made chewing gum lozenge afterwards.
Embodiment 7
Take obtained betelnut extract 10kg in preparation example 3, shitosan 10kg, cornstarch 10kg, maltodextrin 20kg,
Essence 10kg, adhesive 20kg, maltitol 20kg are mixed, and are ground and are crushed 100 mesh sieve, are preheated at 50 DEG C,
Then input mixer is stirred and is mixed into mixed material；The mixed material that will be obtained carries out moulding by casting, is dried in the air at 5-10 DEG C
Postpone and be made chewing gum lozenge.
Experimental example
First, clinical treatment
1st, treatment method
Clinical observation treatment is carried out to 300 migraineurs, wherein man 100, female 200, the age is 14-70 year
Between.
Using the chewing gum lozenge prepared in the embodiment of the present invention 1, each 1 time of morning, noon and afternoon, 2 every time, clothes are chewed after meal.Slightly
Patient takes 30 days or so, and severe case takes 90 days or so.
2nd, curative effect judging standard is：
Cure：Antimigraine and related symptoms are all disappeared, and activity and work are not influenceed, and follow-up half a year is without recurrence；
It is effective：Antimigraine and related symptoms are all disappeared, and symptom substantially mitigates after treatment, and activity and work are not influenceed；
Effectively：Related symptoms and sign have improvement, but unstable condition, there is rebound phenomenon after drug withdrawal；
It is invalid：Clinical symptoms and sign are unchanged or aggravate on the contrary.
3rd, clinical effectiveness
300 patients are carried out with therapeutic effect tracking and follow-up according to above-mentioned criterion of therapeutical effect, record clinical therapeutic efficacy is such as
Under：Clinical cure 281 (93.7%), effective 17 (5.7%), effective 1 (0.3%), invalid 1 (0.3%) is total effective
Rate is 99.7%.
2nd, model case：
Case 1
Lee XX, man, 45 years old, the antimigraine course of disease was 3 years, and per monthly average attack times at 3 times, the duration of breaking out every time is
5 days.Using chewing gum lozenge of the present invention, continuous experiment 3 months, symptom disappears, and no recurrence was observed during the follow-up period of 6 months.
Case 2
King XX, man, 50 years old, the antimigraine course of disease 3 years was averagely monthly broken out 2-3 times, and the breaking-out duration is 2-3 days every time.
Using chewing gum lozenge of the present invention, continuous experiment 3 months, symptom disappears, and no recurrence was observed during the follow-up period of 6 months.
Case 3
Field XX, female 52 years old, stays up late cause intermittent antimigraine for a long time.Through taking chewing gum lozenge of the present invention 2 months, disease
Shape mitigates, and recovery from illness in 2 months is taken again, and no recurrence was observed during the follow-up period of 6 months.
Obviously, above-described embodiment is only intended to clearly illustrate example, and not to the restriction of implementation method.It is right
For those of ordinary skill in the art, can also make on the basis of the above description other multi-forms change or
Change.There is no need and unable to be exhaustive to all of implementation method.And the obvious change thus extended out or
Among changing still in the protection domain of the invention.
Claims (10)
1. a kind of betel nut shitosan chewing gum lozenge, it is characterised in that in terms of the total amount of the chewing gum lozenge, including following matter
Measure the raw material of content：
Betelnut extract 0.1-40wt%；
Shitosan 10-40wt%；
Auxiliary material surplus.
2. betel nut shitosan chewing gum lozenge according to claim 1, it is characterised in that with the total of the chewing gum lozenge
Gauge, including following mass content raw material：
Betelnut extract 0.1-40wt%；
Shitosan 10-40wt%；
Cornstarch 10-20wt%；
Maltodextrin 20-40wt%；
Essence 1-10wt%；
Adhesive 5-20wt%；
Polyalcohol 0-20wt%.
3. betel nut shitosan chewing gum lozenge according to claim 1 and 2, it is characterised in that the betelnut extract bag
Mass ratio is included for 10-70：The total starches and total polyphenols of 5-30.
4. betel nut shitosan chewing gum lozenge according to claim 3, it is characterised in that with the total of the betelnut extract
The mass percent of gauge, the total starches and total polyphenols is at least 15wt%.
5. the betel nut shitosan chewing gum lozenge according to claim 3 or 4, it is characterised in that the betelnut extract is pressed
Gained is extracted according to following method：
(1) squeezing is extracted：Fresh betel nut is crushed and physical squeezing is carried out, collection fruit juice is separated by filtration, while it is standby to merge residue
With；
(2) residue is extracted：Add water mixing in residue, and adds the low-temperature cellulase to carry out biological cracking, then regulation reaction
Liquid pH value 2-7, filters to obtain extract solution；
(3) it is dehydrated：Gained fruit juice in gained extract solution and step (1) is merged to carry out dewater treatment and obtains solids, as required
Betelnut extract active component.
6. betel nut shitosan chewing gum lozenge according to claim 5, it is characterised in that described low in the step (2)
The addition of warm cellulase accounts for the 0.05%-1wt% of the residue weight, and the addition of the water is the 3-10 of the residue
Times of weight amount.
7. the betel nut shitosan chewing gum lozenge according to claim any one of 1-6, it is characterised in that the polyalcohol bag
Include the composition of one or more in xylitol, sorbierite, maltitol, lactitol.
8. a kind of method of the betel nut shitosan chewing gum lozenge prepared described in claim any one of 1-7, it is characterised in that bag
Include and take a selected amount of betelnut extract, shitosan, cornstarch, maltodextrin, essence, adhesive, polyalcohol, grind simultaneously
After preheating, mix mixed material the step of；And by gained mixed material moulding by casting, the chewing gum is obtained final product after hanging and is contained
Piece.
9. the method for preparing betel nut shitosan chewing gum lozenge according to claim 8, it is characterised in that the preheating step
Rapid temperature is 40-60 DEG C, and the step temperature that hangs is for 5-10 DEG C.
10. the betel nut shitosan chewing gum lozenge described in any one of claim 1-7 is used to prepare the use for the treatment of migraine remedy
On the way.
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| CN108477373A (en) * | 2018-04-27 | 2018-09-04 | 湖南口味王集团有限责任公司 | A kind of betel nut pressed candy and preparation method thereof |
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