CN106716138B - 用于确定细胞年龄的系统和方法 - Google Patents

用于确定细胞年龄的系统和方法 Download PDF

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CN106716138B
CN106716138B CN201580048799.4A CN201580048799A CN106716138B CN 106716138 B CN106716138 B CN 106716138B CN 201580048799 A CN201580048799 A CN 201580048799A CN 106716138 B CN106716138 B CN 106716138B
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hba1c
fraction
cell
value
red blood
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CN106716138A (zh
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安德里斯·范艾格斯霍芬
法布里斯·马莱格
克里斯托夫·戈德弗罗伊
恩里克·拉贝力诺
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Beckman Coulter Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/492—Determining multiple analytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/726—Devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/012—Red blood cells
    • G01N2015/014—Reticulocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1402—Data analysis by thresholding or gating operations performed on the acquired signals or stored data
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1477—Multiparameters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1488—Methods for deciding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/795—Porphyrin- or corrin-ring-containing peptides
    • G01N2333/805—Haemoglobins; Myoglobins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201580048799.4A 2014-09-12 2015-09-11 用于确定细胞年龄的系统和方法 Active CN106716138B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462049970P 2014-09-12 2014-09-12
US62/049,970 2014-09-12
US201462059684P 2014-10-03 2014-10-03
US62/059,684 2014-10-03
PCT/US2015/049797 WO2016040870A1 (en) 2014-09-12 2015-09-11 Systems and methods to determine the age of cells

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CN106716138A CN106716138A (zh) 2017-05-24
CN106716138B true CN106716138B (zh) 2019-06-14

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US (1) US10739357B2 (enExample)
EP (1) EP3191848A1 (enExample)
JP (1) JP2017528715A (enExample)
CN (1) CN106716138B (enExample)
WO (1) WO2016040870A1 (enExample)

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Publication number Priority date Publication date Assignee Title
FR3013360B1 (fr) * 2013-11-19 2015-12-04 Snecma Procede integre de frittage pour microfissuration et tenue a l'erosion des barrieres thermiques
SG11201908847TA (en) * 2017-03-31 2019-10-30 Life Technologies Corp Apparatuses, systems and methods for imaging flow cytometry
JP7254916B2 (ja) * 2018-10-26 2023-04-10 アボット ダイアベティス ケア インコーポレイテッド 生理学的パラメータ分析のための方法、デバイスおよびシステム
CA3157672A1 (en) 2019-11-25 2021-06-03 Abbott Diabetes Care Inc. Methods, devices, and systems for physiological parameter analysis
JP2021103139A (ja) * 2019-12-25 2021-07-15 ソニーグループ株式会社 情報処理装置、粒子測定装置、粒子測定システム、粒子分取装置、粒子分取システム、情報処理方法、及び情報処理プログラム
CN112305207B (zh) * 2020-10-20 2023-03-10 上海交通大学 基于HbA1c和血糖浓度为传感变量的红细胞平均寿命检测方法
WO2024094854A1 (en) * 2022-11-03 2024-05-10 Institut National de la Santé et de la Recherche Médicale Method for determining the relative age of red blood cells
WO2025210140A1 (en) * 2024-04-04 2025-10-09 Institut National de la Santé et de la Recherche Médicale Method for determining the age of red blood cells

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992017107A3 (en) * 1991-04-08 1992-11-12 Chronomed Inc Method and apparatus for analyzing the glycation of hemoglobin
US20070020612A1 (en) * 2005-02-07 2007-01-25 Beckman Coulter, Inc. Method of measurement of cellular hemoglobin
US20070267361A1 (en) * 2005-10-28 2007-11-22 Tyvoll David A Systems and methods for measuring glycated hemoglobin
WO2010019372A1 (en) * 2008-08-13 2010-02-18 Beckman Coulter, Inc. Reference control for cell by cell analysis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8481323B2 (en) * 2005-10-28 2013-07-09 Hewlett-Packard Development Company, L.P. Systems and methods for measuring glycated hemoglobin
EP2433140B1 (en) * 2009-05-20 2015-02-11 Relia Diagnostic Systems, Inc. Systems and methods for determining the percentage of glycated hemoglobin

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992017107A3 (en) * 1991-04-08 1992-11-12 Chronomed Inc Method and apparatus for analyzing the glycation of hemoglobin
US20070020612A1 (en) * 2005-02-07 2007-01-25 Beckman Coulter, Inc. Method of measurement of cellular hemoglobin
US20070267361A1 (en) * 2005-10-28 2007-11-22 Tyvoll David A Systems and methods for measuring glycated hemoglobin
CN101354327A (zh) * 2007-07-27 2009-01-28 惠普开发有限公司 测量糖化血色素的系统和方法
WO2010019372A1 (en) * 2008-08-13 2010-02-18 Beckman Coulter, Inc. Reference control for cell by cell analysis
CN102177437A (zh) * 2008-08-13 2011-09-07 贝克曼考尔特公司 用于逐一细胞分析的参考对照

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JP2017528715A (ja) 2017-09-28
US10739357B2 (en) 2020-08-11
CN106716138A (zh) 2017-05-24
WO2016040870A9 (en) 2017-04-06
WO2016040870A1 (en) 2016-03-17
EP3191848A1 (en) 2017-07-19
US20180231573A1 (en) 2018-08-16

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