CN106692319A - Large-specification Fengliaochangweikang dropping pill and preparation method thereof - Google Patents
Large-specification Fengliaochangweikang dropping pill and preparation method thereof Download PDFInfo
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- CN106692319A CN106692319A CN201510481308.7A CN201510481308A CN106692319A CN 106692319 A CN106692319 A CN 106692319A CN 201510481308 A CN201510481308 A CN 201510481308A CN 106692319 A CN106692319 A CN 106692319A
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Abstract
The invention relates to a medicine for treating acute gastroenteritis caused by unsmooth circulation, vital energy circulation stagnation and dampness retention and dyspepsia such as abdominal distension, stomachache and diarrhea caused by acute gastroenteritis, in particular to an oral solid preparation which is finely prepared from two medicines, namely, daphniphyllum calycinum and polygonum hydropiper. The invention aims to make up deficiency of oral preparations for treating the diseases, and provides a large-specification Fengliaochangweikang dropping pill which is high in bioavailability, low in toxic or side effect, large in drug loading capacity, small in administration pill number and convenient to carry over. The dropping pill provided by the invention is prepared from fine powder and a pharmaceutical carrier as a matrix, the fine powder is made by drying and crushing extracts of the two medicinal materials, namely, daphniphyllum calycinum and polygonum hydropiper, and the specification of the large-specification Fengliaochangweikang dropping pill can be 250mg or greater.
Description
Technical field
There is qi-regulating stomach invigorating the present invention relates to one kind, except the oral solid formulation of the stagnant effect of humidifying, it is mainly used in treatment not transporting strong, the stagnation of the circulation of vital energy is wet tired and the acute gastroenteritis that causes and its caused abdominal distension, stomachache and the indigestion, the big specification sweet gum knotweed drip pill for intestine and stomach health for more particularly to being refined with daphniphyllum calycinum and the taste medicinal material of polygonum flaccidum two such as suffer from diarrhoea.
Background technology
'Fengliaochangweikang' ' preparation is one has qi-regulating stomach invigorating, and except the Chinese medicine oral administration solid preparations of the stagnant effect of humidifying, for not transported strong in treatment, the stagnation of the circulation of vital energy is wet tired and the Chinese medicine preparation of the acute gastroenteritis that causes and its caused abdominal distension, stomachache and the indigestion such as suffer from diarrhoea.In prescription composition, the acid of polygonum flaccidum taste is pungent is warm in nature, there is the functions such as dampness elimination, stagnant, the wind-dispelling of row, detumescence, cures mainly cat fever, and heat is rushed down, dysentery etc.；Daphniphyllum calycinum bitter and puckery flavor, it is mild-natured, have clearing heat and detoxicating, promoting blood circulation and removing blood stasis, swell clearly pain-relieving functions, cures mainly cat fever, and consumptive disease is coughed heat and rushed down, dysentery etc..Modern medicine study finds that both polygonum flaccidum and daphniphyllum calycinum compatibility, using medicines of both cold and hot natures simultaneously are gone forward side by side with YIN and YANG balance regulating toil, stomach is obtained with lifting is multiple normal, the physiological function of recovery intestines and stomach., in treatment because the acute gastroenteritis that syndrome of dampness-heat and food stagnation card cause works well, determined curative effect, compatibility is reasonable, without obvious toxic-side effects for said preparation.
At present, the main formulation of said preparation is tablet.As the tablet of conventional dosage forms, there is different degrees of defect in technique preparation and bioavilability.And as one in Chinese medicine preparation relatively new formulation pill, using advanced preparation means, extract (including part refractory components) or main ingredient are added into specific carrier (matrix or auxiliary material), a kind of medicine solid dispersion in a highly dispersed state is made by what solid dispersion technology was made.Moistened because carrier has to medicine, hinder aggregation, solubilising and suppression crystalline substance effect, medicine is main in matrix to be existed with molecule, crystallite or colloidal state, increases medicine total surface area.Effective Component of Chinese Medicine can be made to pass through mucous membrane upper surface cell absorb, directly enter people's circulatory system, blood circulation system is directly absorbed into without liver, being effectively prevented from first pass effect has curative effect rapid, the characteristics of bioavilability is high, Small side effects, medication facilitate.But the common general ball of pill weighs 0.1 gram or so, there is a problem of taking that grain number is more, drugloading rate is small.
As range of application of the dripping pill technology in prescriptions of traditional Chinese medicine is widened, and the exploitation of big specification dripping pill medicine machine, under the conditions of the conventional dropping preparation method of traditional dripping pill is not changed, using quantitative programmed control method, a series of balls are have developed great in 0.1 gram, in 0.5 gram or so of Chinese medicine large dripping pillar.Compared to more traditional dripping pill, its drugloading rate of Chinese medicine large dripping pillar is big, is made that sustained release agent possibility is big, to adapt to prescription scope wide (prescription flavour of a drug number up to 10 tastes more than).Controllability is high, yield is good during its dripping simultaneously, administration grain number is few, takes more convenient, and technology content is also higher.Both the advantage of pill had been remained, the deficiency of conventional pill had been overcome again, met basic demand and growing clinical needs of the people to modern medicines preparation, be that the modernization of Chinese medicine brings new vitality.
Therefore with reference to the drawbacks of modern crafts preparation and small dripping pill, former 'Fengliaochangweikang' ' piece is changed to large dripping pillar agent, for clinic provides a new medication selection, the demand of abundant clinical application, reduce preparation cost, so that the total quality level of preparation is improved, the burden of patient is reduced, for promoting the modernization of Chinese medicine preparation also big favourable.
The content of the invention
The purpose of the present invention, is the deficiency of the oral formulations for supplementing the existing medicine, there is provided a kind of preparation process is simple, the big specification sweet gum knotweed drip pill for intestine and stomach health preparation of convenient to take, bioavilability oral administration solid high, to meet clinical needs.
The big specification sweet gum knotweed drip pill for intestine and stomach health preparation that the present invention is provided, it mainly constitutes and is：Daphniphyllum calycinum, polygonum flaccidum, matrix.
The auxiliary material mesostroma that the present invention is provided mixes composition with Macrogol 6000 for Macrogol 4000.
The big specification sweet gum knotweed drip pill for intestine and stomach health preparation that the present invention is provided is great in 250mg per ball.
The preparation method of specification sweet gum knotweed drip pill for intestine and stomach health preparation of the invention big is：1. the daphniphyllum calycinum and the taste medicinal material of polygonum flaccidum two of recipe quantity are taken, is added water to cook, add the decocting of 10 times of amounts to boil for the first time 1.5 hours, add the decocting of 8 times of amounts to boil for the second time 1 hour, collecting decoction is filtered, and filtrate is concentrated into paste, standby in dry, pulverize into fine powder at 80 DEG C；2. the weight proportion of each component is pressed, makees to be mixed with medicinal extract after matrix is melted with Macrogol 4000 and Macrogol 6000, upper pill dripping machine, dripping.
Specific embodiment
Now face is described further to big specification sweet gum knotweed drip pill for intestine and stomach health of the present invention by way of example again：
Embodiment 1：
Daphniphyllum calycinum
4000g
Polygonum flaccidum
2000g
Macrogol 4000
100g
Macrogol 6000
100g
It is made altogether
1000 balls
The two taste medicinal materials above of recipe quantity are taken, is added water to cook twice, add the decocting of 10 times of amounts to boil for the first time 1.5 hours, add the decocting of 8 times of amounts to boil for the second time 1 hour, collecting decoction, filtration, filtrate is concentrated into paste, in dry, pulverize into fine powder at 80 DEG C, with Macrogol 4000 and Macrogol 6000（1：1）Mixed with medicinal extract after making matrix melting, upper pill dripping machine, dripping pelletization, you can.
Embodiment 2：
Daphniphyllum calycinum
4000g
Polygonum flaccidum
2000g
Macrogol 4000
100g
Macrogol 6000
150g
It is made altogether
1000 balls
The two taste medicinal materials above of recipe quantity are taken, is added water to cook twice, add the decocting of 10 times of amounts to boil for the first time 1.5 hours, add the decocting of 8 times of amounts to boil for the second time 1 hour, collecting decoction, filtration, filtrate is concentrated into paste, in dry, pulverize into fine powder at 80 DEG C, with Macrogol 4000 and Macrogol 6000（1：1.5）Mixed with medicinal extract after making matrix melting, upper pill dripping machine, dripping pelletization, you can.
Claims (7)
1. a kind of big specification sweet gum knotweed drip pill for intestine and stomach health preparation for being mainly used in the indigestions such as middle fortune is not good for, the stagnation of the circulation of vital energy is wet tired and is caused acute gastroenteritis and its caused abdominal distension, stomachache and diarrhoea, is mainly prepared from daphniphyllum calycinum, polygonum flaccidum, matrix.
2. specification sweet gum knotweed drip pill for intestine and stomach health preparation as claimed in claim 1 big, it is characterised in that by the water extract of daphniphyllum calycinum and the taste medicinal material of polygonum flaccidum two through drying and crushing, gained fine powder is prepared from big specification dripping pill to said preparation together with pharmaceutical acceptable carrier.
3. specification sweet gum knotweed drip pill for intestine and stomach health preparation as claimed in claim 1 big, it is characterised in that：It is great in 250mg per ball.
4. specification sweet gum knotweed drip pill for intestine and stomach health preparation as claimed in claim 1 big, it is characterized in that daphniphyllum calycinum is 1 with polygonum flaccidum crude drug weight ratio:1~1:2.
5. specification sweet gum knotweed drip pill for intestine and stomach health preparation as claimed in claim 1 big, it is characterized in that matrix mixes composition with Macrogol 6000 for Macrogol 4000.
6. specification sweet gum knotweed drip pill for intestine and stomach health preparation as claimed in claim 1 big, it is characterized in that both matrix Macrogol 4000 and Macrogol 6000 mixed weight ratio are 1:1~1:2.
7. specification sweet gum knotweed drip pill for intestine and stomach health preparation as claimed in claim 1 big, it is characterised in that main preparation process is as follows：
7.1
By the weight proportion of each component, daphniphyllum calycinum and the taste medicinal material of polygonum flaccidum two are taken, added water to cook, add the decocting of 10 times of amounts to boil for the first time 1.5 hours, the decocting of 8 times of amounts is added for second to boil 1 hour, collecting decoction, filtration, filtrate is concentrated into paste, it is standby in dry, pulverize into fine powder at 80 DEG C；
7.2
By the weight proportion of each component, make to be mixed with medicinal extract after matrix is melted with Macrogol 4000 and Macrogol 6000, upper pill dripping machine, dripping.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510481308.7A CN106692319A (en) | 2015-08-10 | 2015-08-10 | Large-specification Fengliaochangweikang dropping pill and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510481308.7A CN106692319A (en) | 2015-08-10 | 2015-08-10 | Large-specification Fengliaochangweikang dropping pill and preparation method thereof |
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| Publication Number | Publication Date |
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| CN106692319A true CN106692319A (en) | 2017-05-24 |
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| CN201510481308.7A Pending CN106692319A (en) | 2015-08-10 | 2015-08-10 | Large-specification Fengliaochangweikang dropping pill and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111714462A (en) * | 2020-07-31 | 2020-09-29 | 海南卓力制药有限公司 | Preparation method of daphniphyllum calycinum and polygonum hydropiper intestine and stomach rehabilitation dropping pills |
-
2015
- 2015-08-10 CN CN201510481308.7A patent/CN106692319A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111714462A (en) * | 2020-07-31 | 2020-09-29 | 海南卓力制药有限公司 | Preparation method of daphniphyllum calycinum and polygonum hydropiper intestine and stomach rehabilitation dropping pills |
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Application publication date: 20170524 |