CN106692245A - Medicinal composition having heat clearing, detoxifying, swelling eliminating and throat disinhibiting effects - Google Patents
Medicinal composition having heat clearing, detoxifying, swelling eliminating and throat disinhibiting effects Download PDFInfo
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- CN106692245A CN106692245A CN201510494667.6A CN201510494667A CN106692245A CN 106692245 A CN106692245 A CN 106692245A CN 201510494667 A CN201510494667 A CN 201510494667A CN 106692245 A CN106692245 A CN 106692245A
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Abstract
The invention provides a medicinal composition having heat clearing, detoxifying, swelling eliminating and throat disinhibiting effects. Raw medicines of the medicinal composition comprise Herba Taraxaci, wild chrysanthemum flowers, stiff silkworms, scorpions, borneol and pearl powder. Animal medicine effect test and clinic test observation prove that the medicinal composition is safe and effective.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of pharmaceutical composition with clearing heat and detoxicating detumescence relieving sore-throat effect.
Background technology
Tonsillitis and pharyngitis are otorhinolaryngologic common disease frequently-occurring diseases, are mostly occurred in the middle of Children and teenager crowd, the most susceptible disease typically when temperature drastically changes.If acute tonsillitis and acpuei pharyngitis cannot be treated effectively, normal recurrent exerbation switchs to chronic.Doctor trained in Western medicine generally uses antibiotic, antiviral drugs or local treatment and carries out symptomatic treatment for the treatment of tonsillitis and pharyngitis, but the long-time repeatedly of antibiotic is applied, and can cause bacterial resistance, it is also possible to can produce the adverse reactions such as allergy.
The content of the invention
It is an object of the invention to provide it is a kind of with it is clearing heat and detoxicating, detumescence relieving sore-throat effect Chinese medicine composition and its preparation, preparation method and application, said composition with traditional Chinese medical theory as scientific composition is instructed, for the treatment of pharyngitis and tonsillitis.
The purpose of the present invention is achieved by the following technical solution：
A kind of Chinese medicine composition with clearing heat and detoxicating detumescence relieving sore-throat effect, its bulk drug composition is dandelion, chrysanthemum indicum, stiff silkworm, scorpio, borneol, pearl powder.Wherein, the bulk drug composition and ratio is the weight portion of dandelion 400 ~ 800, the weight portion of chrysanthemum indicum 200 ~ 600, the weight portion of stiff silkworm 200 ~ 600, the weight portion of scorpio 10 ~ 150, the weight portion of borneol 20 ~ 250, the weight portion of pearl powder 20 ~ 250.
Further, the bulk drug composition and ratio is preferably the weight portion of dandelion 500 ~ 700, the weight portion of chrysanthemum indicum 300 ~ 500, the weight portion of stiff silkworm 300 ~ 500, the weight portion of scorpio 20 ~ 120, the weight portion of borneol 50 ~ 200, the weight portion of pearl powder 50 ~ 200.
Further, the bulk drug composition and ratio is preferably the weight portion of dandelion 550 ~ 650, the weight portion of chrysanthemum indicum 350 ~ 450, the weight portion of stiff silkworm 350 ~ 450, the weight portion of scorpio 40 ~ 100, the weight portion of borneol 80 ~ 160, the weight portion of pearl powder 80 ~ 160.
Chinese medicine composition of the present invention adds customary adjuvant, according to common process, pharmaceutically acceptable various formulations, including but not limited to pill, powder, lozenge, soft extract, jelly, syrup, emplastrum, ointment, tablet, pill, capsule, granule, pill, oral liquid can be made.
One of according to the embodiment of the present invention, the pharmaceutical composition can be external preparation.
Another implementation method of the invention, the pharmaceutical composition adds customary adjuvant, according to common process, is made ointment.
Present invention also offers the preparation method of the pharmaceutical composition, comprise the following steps：
Take the weight portion of dandelion 400 ~ 800, the weight portion of chrysanthemum indicum 200 ~ 600, the weight portion of stiff silkworm 200 ~ 600, the weight portion of scorpio 10 ~ 150, the weight portion of borneol 20 ~ 250, the weight portion of pearl powder 20 ~ 250；
By dandelion, chrysanthemum indicum, stiff silkworm, add water to cook, filter, concentration is dried to extract dry cream, crushes, standby；
Scorpio, borneol are ground into fine powder, are well mixed with said extracted thing dried cream powder, pearl powder；
Customary adjuvant is added, ointment is made.
One of according to the embodiment of the present invention, auxiliary material includes one or more in vaseline, paraffin, liquid paraffin, beeswax, stearic acid, polyethylene glycol, glycerine, silicone oil, semi-synthetic fatty glyceride, lecithin, soda soap, trihydroxy ethylamine oleate soap, lauryl sodium sulfate, polysorbate, lanolin, monoglyceride, fatty alcohol, silica, azone.
Pharmaceutical composition of the present invention is by the animal test of pesticide effectiveness and Clinical observation, it was demonstrated that it is safely, effectively.Wherein in the experiment influenceed on hot plate method in mice induced pain, pharmaceutical composition of the present invention can effectively extend mouse incubation period, the lifting mouse threshold of pain；Compared with positive controls, effect is more excellent；In the experiment that paraxylene causes mice auricle swelling influence, compared with vehicle control group, pharmaceutical composition of the present invention can effectively reduce mice auricle swelling degree, show certain antiinflammatory action.Meanwhile, by clinical observation on the therapeutic effect, the inflammation that pharmaceutical composition of the present invention causes to the treatment infection of the upper respiratory tract, particularly tonsillitis and pharyngitis aspect have preferable clinical efficacy, and acute phase inflammatory effect is especially protruded.
Specific embodiment
Following embodiments are used to further proving but being not limited to the present invention.
Embodiment one：Ointment
Dandelion 580g, chrysanthemum indicum 380g, stiff silkworm 380g, scorpio 60g, borneol 110g, pearl powder 110g
Dandelion, chrysanthemum indicum, stiff silkworm are taken, is added water to cook, filtered, concentration is dried to extract dry cream, crushes, standby；Scorpio, borneol are crushed, and make into most fine powder, are well mixed with said extracted thing dried cream powder, pearl powder, add the customary adjuvants such as vaseline, lanolin, are made ointment.
Embodiment two：Powder
Dandelion 550g, chrysanthemum indicum 450g, stiff silkworm 350g, scorpio 100g, borneol 160g, pearl powder 80g
Above-mentioned raw materials medicine is taken, adds lactose to be fluidized in batch (-type) fluid bed, powder is made according to common process.
Embodiment three：Tablet
Dandelion 650g, chrysanthemum indicum 350g, stiff silkworm 450g, scorpio 40g, borneol 80g, pearl powder 160g
Above-mentioned raw materials medicine is taken, microcrystalline cellulose, talcum powder is added, tablet is made according to common process.
Example IV：Capsule
Dandelion 560g, chrysanthemum indicum 430g, stiff silkworm 370g, scorpio 85g, borneol 140g, pearl powder 100g
Above-mentioned raw materials medicine is taken, gel and glycerine is added, capsule is made according to common process.
Embodiment five：Oral liquid
Dandelion 620g, chrysanthemum indicum 360g, stiff silkworm 420g, scorpio 50g, borneol 95g, pearl powder 150g
Above-mentioned raw materials medicine is taken, merging filtrate after water extract-alcohol precipitation adds sucrose and sorbierite, and oral liquid is made according to common process.
Embodiment six：Granule
Dandelion 500g, chrysanthemum indicum 500g, stiff silkworm 300g, scorpio 120g, borneol 200g, pearl powder 50g
Above-mentioned raw materials medicine is taken, magnesium stearate, starch and appropriate PVP is added, granule is made according to common process.
Embodiment seven：Pill
Dandelion 700g, chrysanthemum indicum 300g, stiff silkworm 500g, scorpio 20g, borneol 50g, pearl powder 200g
Above-mentioned raw materials medicine is taken, microcrystalline cellulose, starch and appropriate PVP is added, pill is made according to common process.
Embodiment eight：Ointment
Dandelion 520g, chrysanthemum indicum 480g, stiff silkworm 320g, scorpio 110g, borneol 180g, pearl powder 60g
Above-mentioned raw materials medicine is taken, polyethylene glycol is added, ointment is made according to common process.
Embodiment nine：Dispersible tablet
Dandelion 680g, chrysanthemum indicum 320g, stiff silkworm 480g, scorpio 30g, borneol 70g, pearl powder 180g
Above-mentioned raw materials medicine is taken, disintegrant Ac-Di-Sol, filler starch and binder polyvinylpyrrolidone is added, dispersible tablet is made according to common process.
Embodiment ten：Powder
Dandelion 400g, chrysanthemum indicum 600g, stiff silkworm 200g, scorpio 150g, borneol 250g, pearl powder 20g
Above-mentioned raw materials medicine is taken, most fine powder is ground into, powder is made according to common process.
Embodiment 11：Dripping pill
Dandelion 800g, chrysanthemum indicum 200g, stiff silkworm 600g, scorpio 10g, borneol 20g, pearl powder 250g
Above-mentioned raw materials medicine is taken, Macrogol 6000 is added, dripping pill is made according to common process.
Embodiment 12：Sustained release tablets
Dandelion 450g, chrysanthemum indicum 550g, stiff silkworm 250g, scorpio 140g, borneol 230g, pearl powder 35g
Above-mentioned raw materials medicine is taken, ethyl cellulose, polyethylene is added, sustained release tablets are made according to common process.
Embodiment 13：Oral liquid
Dandelion 750g, chrysanthemum indicum 520g, stiff silkworm 550g, scorpio 15g, borneol 40g, pearl powder 230g
Above-mentioned raw materials medicine is taken, merging filtrate after water extract-alcohol precipitation adds sucrose and sorbic acid, and oral liquid is made according to common process.
Embodiment 14：The animal test of pesticide effectiveness
（One）Experiment material：
1st, medicine and reagent
Test sample：Prepared by the method for embodiment one.
Control drug：GUILIN XIGUA SHUANG, Sanjin Pharmaceutical Co., Ltd., Guilin's production.
Reagent：Dimethylbenzene, Nanjing Chemistry Reagent Co., Ltd..
2nd, experimental animal：
SPF grades of ICR mouse, body weight 18-22g, female is provided, quality certification number by Shanghai Jie Sijie experimental animals Co., Ltd：SCXK（Shanghai）2012-0006.SPF grades of ICR mouse, body weight 25-27g, male is provided, quality certification number by Shanghai Jie Sijie experimental animals Co., Ltd：SCXK（Shanghai）2012-0006.
3rd, laboratory apparatus：
RB-200 intelligence hot-plate instruments：Chengdu TME Technology Co., Ltd.；BS 224s type electronic balances：Beijing Sai Duolisi instrument systems Co., Ltd product.
（Two）Experimental technique：
1st, influence of the test sample to hot plate method in mice induced pain
（1）The screening of qualified small white mouse：18~22g of body weight female small white mouses are taken, every group 10,8 groups is divided into, by hot plate temperature control at 55 DEG C ± 0.5 DEG C, one is merely placed on hot plate every time, small white mouse up to occurs licking metapedes required time from hot plate is placed on（s）It is all to lick the sufficient time less than 10s or being given it up more than 30s or leaper as the pain threshold of small white mouse, every group reach 10 it is qualified untill, its pain threshold is surveyed after 10min, take twice average value as pain threshold before administration.
（2）Small white mouse of the selection incubation period between 10~30s divides equally 4 groups：Vehicle control group, positive controls（GUILIN XIGUA SHUANG）, test sample group：（1 patch/time, 1 times/day, ointment consumption be 0.1760 g/time）.The animal for giving test sample is lost hair or feathers using 6% vulcanized sodium belly, is affixed on depilation skin, once a day, 12h is sticked every time；Blank group gives distilled water.Patch is orally administered 7 days.Last stick or gastric infusion after 1 h start survey the threshold of pain, successively survey 15,30,60,90, the threshold of pain of 120min, seek its average value, in 60s nonresponder take out the threshold of pain with 60s calculate.Acquired results are between grouptInspection carries out statistical analysis.
2nd, test sample paraxylene causes the influence of mice auricle swelling
Mouse 80, male, 25~27g of body weight is divided into 4 groups at random.Vehicle control group, positive controls（GUILIN XIGUA SHUANG）, test sample group：（1 patch/time, 1 times/day, ointment consumption be 0.1760 g/time）.The animal for giving test sample is lost hair or feathers using 6% vulcanized sodium belly, is affixed on depilation skin, once a day, 12 h is sticked every time；Blank group gives isometric distilled water.Patch is orally administered 7 days.Last stick or gastric infusion after 1 h dimethylbenzene 0.2ml be applied to small white mouse auris dextra it is wide before and after two sides cause inflammation 30min after put to death animal, left and right auricle is cut in the symmetrical place of ears, swept away in the symmetrical place of ears with the card punch that internal diameter is 8mm, weighed on 1/,100,000 balance, it is swelling with two ear weight differences of left and right, and calculates inhibiting rate.Each administration group swelling and vehicle control group carry out t inspections between group.
（Three）Experimental result
1st, influence of the test sample to hot plate method in mice induced pain
Influence of the test sample of table 1. to hot plate method in mice induced pain（
± s, n=10）
*P<0.05,**
P<0.01 vs. vehicle control groups；#P<0.05,# #P<0.01 vs. positive controls.
As shown in Table 1, compared with vehicle control group, before administration, each group there are no significant difference（P ﹥ 0.05）；After administration, positive controls（GUILIN XIGUA SHUANG）Being capable of conspicuousness extension incubation period（P<0.05）, test sample group being capable of pole conspicuousness extension incubation period（P<0.01）.With positive controls（GUILIN XIGUA SHUANG）Compare, test sample group incubation period significantly extends（P<0.05）.
2nd, test sample paraxylene causes the influence of mice auricle swelling
The test sample paraxylene of table 2. causes the influence of mice auricle swelling（± s, n=10）
*P<0.05,**
P<0.01 vs. vehicle control groups.
As shown in Table 2, compared with vehicle control group, positive controls（GUILIN XIGUA SHUANG）Mice auricle swelling degree can be significantly reduced with test sample group（P<0.05）.
（Four）Experiment conclusion：
From result above, in the experiment that test sample influences on hot plate method in mice induced pain, test sample group can effectively extend mouse incubation period, lifting mouse pain domain；Compared with positive controls, effect is more excellent.In the experiment that test sample paraxylene causes mice auricle swelling influence, compared with vehicle control group, test sample group can effectively reduce mice auricle swelling degree, show certain antiinflammatory action.
Embodiment 15：Clinical test
（One）Experimental technique：
Experimental design is using the random method being grouped.
（Two）Case selection：
2.1 diagnostic criteria
2.1.1 Western medicine diagnostic criteria：
Acute congestive tonsillitis：
1. it is often a part for the infection of the upper respiratory tract, abscess of throat；
2. it is many with acute rhinitis, pharyngitis, laryngitis etc.；
3. tonsillotome surface mucosa is congested, can occasionally there is exudate；
4. whole body and local symptom are lighter；
5. it is generally virus infection.
Acpuei pharyngitis：
1. it is often the infection of the upper respiratory tract and the premonitory symptom of some infectious diseases such as measles, scarlet fever, rubella etc., pharyngalgia, congestion of throat；
2. with generating heat, ooze out, slight cough and rhinorrhea；
3. 50% is virus infection.
2.1.2 tcm diagnosis standard：
Acute tonsillitis：
1. primary symptom：Sore-throat or odynophagia, larynx core redness (antiadoncus)；
2. secondary disease：Swallow red (pharynx mucous hyperemia), heating, micro- foul wind, cough, headache；
3. tongue fur pulse condition：The thin white, superficial and rapid pulse of red tongue body, tongue.
Acute throat obstruction：
1. primary symptom：Pharyngalgia, swallows mucous membrane swelling；
2. secondary disease：Pharyngalgia and it is thirsty, heating, slight chill, pharyngeal mild hyperaemia, oedema；
3. tongue fur pulse condition：The thin white, superficial and rapid pulse of red tongue body, tongue.
Note：Primary symptom is indispensable, secondary disease >=2, and combines tongue fur pulse condition, you can be diagnosed as acute tonsillitis or acute throat obstruction (wind-heat syndrome).
2.2 inclusive criterias：
1. children's acute congestive tonsillitis or children's acute pharyngitis Western medicine diagnostic criteria are met；
2. paediatric acute tonsillitis or children's acute pharyngitis external wind heat syndrome tcm diagnosis standard are met
3. age 3-14 Sui；
4. the course of disease is within 48h；
5. parents of hospitalized children or guardian's informed consent, and sign Informed Consent Form.
2.3 exclusion standards：
Meet following any 1, observation case must not be included.
1. body temperature is more than 38.5 DEG C of persons；
2. abscess of throat does not meet traditional Chinese and western medicine diagnostic criteria person；
3. children suppurative tonsillitis person；
4. the breathing problem persons such as pneumonia, bronchitis, serious laryngitis are merged：
5. severe malnutrition, or with the system severe primary disease such as other hearts, liver, kidney and hematopoiesis, mental patient；
6. to known this preparation constituent allergy sufferers；
7. go to a doctor the person that receives antibiotic therapy in the last week.
（Three）Therapeutic process：
3.1 experiment medicines：
A groups are test sample group：Prepared by the method for embodiment one；
B groups are blank group：The auxiliary materials such as vaseline, lanolin, silica, glycerine, paraffin, azone are taken, a small amount of pigment is added, mother's salve is made.
3.2 dosage regimens：
Two groups of A, B, is affixed on both sides lower jaw part, and one time 2 patch once a day, is once pasted 12 hours.
3.3 courses for the treatment of：5 days as one therapeutic course.
3.4 drug combinations specify：
During experiment, antibiotic, antiviral and similar Chinese medicine must not be used.
Occur making symptomatic treatment during situations below：
(l) hyperpyrexia：Armpit temperature >=38.5 DEG C (previously have hyperpyretic convulsion history person can suitably relax) give Physical temperature-lowering, warm sponge bath, head cold compress etc. to treat, and give ibuprofen suspension if necessary, each 5-10mg/kg, orally.
(2) abundant expectoration：Give chymotrypsin atomization inspiration treatment.
(3) experiment medication treats 3 days symptoms without improvement, and other symptomatic treatment measures, this experiment should be taken to terminate.
（Four）Evaluation index and method：
4.1 index of assessment of curative effect：
(1) acute congestive tonsillitis and acpuei pharyngitis sign improvement rate；
(2) body temperature normalization rate.
4.2 the standard of curative effect evaluation：
Cure：Constitutional symptom sign disappears, and temperature recovery is normal;Symptom and sign is integrated and slip >=95%.
It is effective：Symptom and sign integration and slip 70-95% in medication 5 days.
Effectively：Symptom and sign integration and slip 30-70% in medication 5 days.
It is invalid：Symptom and sign total mark after treatment<30%.
Note：Slip=(total mark after total mark-treatment before treating)/treat preceding total mark x100%
Body temperature normalization rate：Medication 3 days, and the normal percentage of temperature recovery after 5 days.
It is required that body temperature（Armpit temperature）≤ 37.3 DEG C, and keep 24h and more than.
（Five）Result of the test：
The acute congestive tonsillitis of table 3 and acpuei pharyngitis sign improve
| Group | A groups | B groups |
| Effective case load | 46 | 21 |
| Cure-remarkable-effectiveness rate（%） | 34.8 | 4.7 |
| It is efficient（%） | 58.7 | 19.0 |
| Inefficiency（%） | 6.5 | 76.2 |
Table 4 medication, 3 days body temperature normalization rates
| Group | A groups | B groups |
| Body temperature >=37.3 DEG C case load | 38 | 20 |
| First day normalization rate（%） | 7.8 | 0 |
| Second day normalization rate（%） | 47.36 | 35.00 |
| 3rd day normalization rate（%） | 76.32 | 45.00 |
Conclusion：From in terms of statistics, A groups are substantially better than B groups, show in terms of improving acute congestive tonsillitis and acpuei pharyngitis sign and reducing heating, A groups（That is test sample group）With obvious curative effects.
（Six）Conclusion：
By above Preliminary Clinical Observation, show that test sample group has preferable clinical efficacy in terms for the treatment of acute tonsillitis and acpuei pharyngitis.
Claims (10)
1. a kind of Chinese medicine composition with clearing heat and detoxicating detumescence relieving sore-throat effect, is made up of the bulk drug of following part by weight：The weight portion of dandelion 400 ~ 800, the weight portion of chrysanthemum indicum 200 ~ 600, the weight portion of stiff silkworm 200 ~ 600, the weight portion of scorpio 10 ~ 150, the weight portion of borneol 20 ~ 250, the weight portion of pearl powder 20 ~ 250.
2. Chinese medicine composition as claimed in claim 1, characterized in that, the bulk drug composition and ratio of said composition is the weight portion of dandelion 500 ~ 700, the weight portion of chrysanthemum indicum 300 ~ 500, the weight portion of stiff silkworm 300 ~ 500, the weight portion of scorpio 20 ~ 120, the weight portion of borneol 50 ~ 200, the weight portion of pearl powder 50 ~ 200.
3. Chinese medicine composition as claimed in claim 2, characterized in that, the bulk drug composition and ratio of said composition is the weight portion of dandelion 550 ~ 650, the weight portion of chrysanthemum indicum 350 ~ 450, the weight portion of stiff silkworm 350 ~ 450, the weight portion of scorpio 40 ~ 100, the weight portion of borneol 80 ~ 160, the weight portion of pearl powder 80 ~ 160.
4. one kind includes the pharmaceutical composition such as any Chinese medicine composition of claim 1 ~ 3, it is characterized in that, the Chinese medicine composition adds customary adjuvant, according to common process, it is made pharmaceutically acceptable various formulations, including but not limited to pill, powder, lozenge, soft extract, jelly, syrup, emplastrum, ointment, tablet, pill, capsule, granule, pill, oral liquid.
5. pharmaceutical composition as claimed in claim 4, it is characterised in that the pharmaceutical composition is external preparation.
6. pharmaceutical composition as claimed in claim 4, it is characterised in that the pharmaceutical composition is ointment.
7. a kind of preparation method with clearing heat and detoxicating, detumescence relieving sore-throat effect pharmaceutical composition, comprises the following steps：
Take the weight portion of dandelion 400 ~ 800, the weight portion of chrysanthemum indicum 200 ~ 600, the weight portion of stiff silkworm 200 ~ 600, the weight portion of scorpio 10 ~ 150, the weight portion of borneol 20 ~ 250, the weight portion of pearl powder 20 ~ 250；
By dandelion, chrysanthemum indicum, stiff silkworm, add water to cook, filter, concentration is dried to extract dry cream, crushes, standby；
Scorpio, borneol are ground into fine powder, are well mixed with said extracted thing dried cream powder, pearl powder；
Customary adjuvant is added, ointment is made.
8. preparation method as claimed in claim 7, wherein the accessory package includes one or more in vaseline, paraffin, liquid paraffin, beeswax, stearic acid, polyethylene glycol, glycerine, silicone oil, semi-synthetic fatty glyceride, lecithin, soda soap, trihydroxy ethylamine oleate soap, lauryl sodium sulfate, polysorbate, lanolin, monoglyceride, fatty alcohol, silica, azone.
9. the application of any described Chinese medicine composition of claim 1 ~ 3 or any described pharmaceutical composition of claim 4~6 in the medicine for preparing the inflammation that the treatment infection of the upper respiratory tract causes.
10. application as claimed in claim 9, it is characterised in that the inflammation that the infection of the upper respiratory tract causes is tonsillitis and/or pharyngitis.
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| CN201510494667.6A CN106692245A (en) | 2015-08-13 | 2015-08-13 | Medicinal composition having heat clearing, detoxifying, swelling eliminating and throat disinhibiting effects |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109925344A (en) * | 2017-12-15 | 2019-06-25 | 陈条焕 | A kind of sphagitis, esophagitis rehabilitation Chinese medicine |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1951454A (en) * | 2006-10-25 | 2007-04-25 | 杜幼蕊 | Antiinflammation ointment plaster for treating tonsillitis |
| CN104116958A (en) * | 2014-08-09 | 2014-10-29 | 刘兰英 | Traditional Chinese medicament for treating acute and chronic amygdalitis and preparation method thereof |
| CN104474318A (en) * | 2014-11-24 | 2015-04-01 | 武燕华 | Traditional Chinese medicine composition with effects of clearing away heat and toxic materials |
-
2015
- 2015-08-13 CN CN201510494667.6A patent/CN106692245A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1951454A (en) * | 2006-10-25 | 2007-04-25 | 杜幼蕊 | Antiinflammation ointment plaster for treating tonsillitis |
| CN104116958A (en) * | 2014-08-09 | 2014-10-29 | 刘兰英 | Traditional Chinese medicament for treating acute and chronic amygdalitis and preparation method thereof |
| CN104474318A (en) * | 2014-11-24 | 2015-04-01 | 武燕华 | Traditional Chinese medicine composition with effects of clearing away heat and toxic materials |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109925344A (en) * | 2017-12-15 | 2019-06-25 | 陈条焕 | A kind of sphagitis, esophagitis rehabilitation Chinese medicine |
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Application publication date: 20170524 |