CN106691396A - Intravascular fluorescent-photoacoustic-ultrasonic multi-mode imaging device and method - Google Patents
Intravascular fluorescent-photoacoustic-ultrasonic multi-mode imaging device and method Download PDFInfo
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- CN106691396A CN106691396A CN201710112585.XA CN201710112585A CN106691396A CN 106691396 A CN106691396 A CN 106691396A CN 201710112585 A CN201710112585 A CN 201710112585A CN 106691396 A CN106691396 A CN 106691396A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0891—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
- A61B8/5238—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image
- A61B8/5261—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image combining images from different diagnostic modalities, e.g. ultrasound and X-ray
Abstract
The invention belongs to the field of intravascular endoscope imaging and discloses an intravascular fluorescent-photoacoustic-ultrasonic multi-mode imaging device and method. The device comprises a computer, a fluorescence excitation and acquisition system, a photoacoustic signal excitation and acquisition system, an ultrasonic signal excitation and acquisition system and an integrated probe. The fluorescence excitation and acquisition system comprises a pulsed laser, a first optical filter, a collimator, a first optical fiber coupler, an optical fiber circulator, a photoelectric sliding ring, a second optical fiber coupler, a second optical filter, a photoelectric multiplier tube, a first signal amplifier and a first acquisition card. An intravascular endoscope imaging system in a fluorescent imaging mode, an intravascular endoscope imaging system in a photoacoustic imaging mode and an intravascular endoscope imaging system in an ultrasonic imaging mode are integrated, and due to combination of the advantages of the three imaging modes, structural information of multiple parameters of vessels and component information of corresponding substances can be obtained.
Description
Technical field
The present invention relates to the research field of blood vessel endoscope, more particularly to a kind of Ink vessel transfusing fluorescence-optoacoustic-ultrasound multi-modality imaging
Device and method.
Background technology
Cardiovascular and cerebrovascular disease is present death rate disease higher, and the accuracy of blood vessel checkout and diagnosis there has also been higher
It is required that.The means of modern medicine detection blood vessel have, including magnetic resonance (MRI) blood vessel imaging and angiographic imaging (IVUS) and blood
Inner fluorescent tube is imaged, above several detection means can preferably show the formalness or in-profile and component of blood vessel
Information, but the local detail information of vascular wall and lumen of vessels cannot be provided.Ink vessel transfusing fluorescence imaging is utilized first by fluorescence
Matter injection Ink vessel transfusing is allowed to produce fluorescence by way of laser irradiates again, and blood vessel is carried out into by receiving fluorescence information
As so as to obtain more information
The new bio medical imaging procedure of a kind of non-invasive developed in recent years and unionized formula.When pulse swashs
When illumination is mapped in biological tissue, the light absorbs domain of tissue will produce ultrasonic signal, and we claim this to excite the super of generation by light
Acoustical signal is photoacoustic signal.The photoacoustic signal that biological tissue produces carries the light absorption characteristics information of tissue, by detecting light
Acoustical signal can reconstruct the light absorbs distributed image in tissue.Photoacoustic imaging combines high selection characteristic in pure optical texture imaging
With the advantage of deep penetration characteristic in the imaging of pure ultrasonic tissue, the organization chart picture of high-resolution and high-contrast is can obtain, from principle
On avoid the influence of light scattering, breach high resolution optical imaging depth " soft limiting " (~1mm), be capable of achieving the depth of 50mm
Layer in vivo tissue imaging.
Intravascular ultrasound imaging (IVUS) is that the echo based on detection ultrasonic signal in vascular wall is imaged, and reflects blood
The otherness of tubing acoustic impedance；Intravascular photoacoustic imaging is that the optoacoustic letter produced after pulse laser is absorbed based on detection vascular wall
Number it is imaged, is reflected the optical absorption difference of vascular tissue.Both technologies are respectively from two parameters of acoustic impedance and light absorbs
The upper information for providing blood vessel, two kinds of imaging depths of imaging method can reach more than 10cm, therefore both technologies are fitted very much
Conjunction carries out based endoscopic imaging to blood vessel.
Ink vessel transfusing fluorescence-optoacoustic-ultrasound multi-modality imaging technology combines three kinds of imaging methods, effectively overcomes list
The deficiency of one mode imaging, using the teaching of the invention it is possible to provide Ink vessel transfusing many reference amounts, the information of various dimensions helps to diagnose endovascular patch feelings
Condition.
Application No. 201210046300.4, patent is entitled《A kind of confocal optoacoustic fluorescence is while imaging method and dress
Put》, the method and apparatus that a kind of optoacoustic fluorescence is imaged simultaneously is disclosed, but the device needs microscope real in vitro
Test, it is impossible to be applied to Ink vessel transfusing fluorescence imaging.
Application No. 201010187650.3, patent name is《A kind of intravascular photoacoustic ultrasonic double-mode imaging endoscope dress
Put and its imaging method》Document disclose a kind of technology.The technology is anti-using hollow circular ring array ultrasonic sensors and the conical surface
Mirror is penetrated, during photoacoustic imaging, pulse laser is transmitted by optical fiber and launched at light extraction end, is scattered simultaneously on the face of conical reflector
Whole vascular wall is irradiated, photoacoustic signal is excited, the photoacoustic signal for producing is received using circle ring array ultrasonic detector；Ultrasonic imaging
When circle ring array ultrasonic detector transmitting ultrasonic signal, then receive the ultrasonic signal of vasoreflex, probe have photoacoustic imaging and
The performance of ultrasonic imaging.
Its deficiency is that the pulse laser of the technology is expanded in conical reflector, while whole internal blood vessel is excited, it is required
Laser energy is big；And because pulse laser is not converged, so the resolution ratio of photoacoustic image is not good, the probe of the device in addition
Using 64 acoustic sensors, the receiving efficiency of single acoustic sensor is not good and complex structure.
Application No. 201210220399.5, patent name is《Focusing rotation sweep photoacoustic ultrasound blood vessel endoscope imaging
Device and its imaging method》Document disclose a kind of imaging device, using the device carry out photoacoustic ultrasound integration blood vessel
Interior imaging method research.The direct 90 ° of light extractions of optical fiber connector of the device, laser is divergent irradiation on object under test, and laser does not have
There is convergence, equally exist the coupling of the poor problem of the resolution ratio of photoacoustic image, and device disclosed in the technology, laser and optical fiber
Direct-coupled mode is taken in conjunction, so easily occurs deviation during fiber spinning, so as to cause laser to the biography of optical fiber
Defeated efficiency reduction, directly affects the generation of photoacoustic signal.
The content of the invention
A kind of Ink vessel transfusing fluorescence-optoacoustic-ultrasound multi-modality imaging device is provided, using the device can realize fluorescence-optoacoustic-
The imaging of ultrasonic Three models, can simultaneously obtain Ink vessel transfusing many reference amounts, multi-component information, improve the detection of plaque within blood vessels
Precision.
Another object of the present invention is to provide a kind of method being imaged using above-mentioned imaging device, the imaging is used
Method, can obtain endovascular fluoroscopic image, photoacoustic image and ultrasonoscopy.
In order to reach above-mentioned first purpose, the present invention uses following technical scheme：
A kind of Ink vessel transfusing fluorescence-optoacoustic-ultrasound multi-modality imaging device and method of the present invention, including computer, fluorescence excitation
Excited with acquisition system, photoacoustic signal and excited and acquisition system and integrated probe, blood vessel with acquisition system, ultrasonic signal
Interior fluorescence imaging exciting light and photoacoustic imaging exciting light uses same light source, and by optical fiber circulator carry out Laser Transmission and
Collection；
Wherein, the fluorescence excitation includes with acquisition system：Pulse laser, the first optical filter, collimater, the first optical fiber
Coupler, optical fiber circulator, light electric slip ring, the second fiber coupler, the second optical filter, photomultiplier, the first signal amplify
Device and the first capture card；The computer produces signal excitation pulse laser to produce laser, and it is filtered by the first optical filter
Gone out into port2 mouthfuls by optical fiber circulator port1 mouthfuls by the first fiber coupler and by light electric slip ring by collimater afterwards
Exported for fluorescence excitation by integrated probe, the fluorescence for being excited to produce is received by light electric slip ring through optical fiber by integrated probe
Circulator port2 mouthfuls enters and is gone out by the coupling of the second fiber coupler and by the second optical filter by optical fiber circulator port3 mouthfuls
Photomultiplier detection is sent into after optical filtering, photomultiplier will receive fluorescence signal and be converted into electric signal and put by the first signal
Gathered and sent into computer disposal by the first capture card after big device and rebuild fluoroscopic image；
The photoacoustic signal is excited and included with acquisition system：Pulse laser, the first optical filter, collimater, the first optical fiber
Coupler, optical fiber circulator, light electric slip ring, ultrasound emission receiver, traffic filter, secondary signal amplifier and second
Capture card；The pulse laser be excited generation pulse laser after pass through by the first optical filter filter after by collimater
Gone out into port2 mouthfuls by optical fiber circulator port1 mouthfuls by the first fiber coupler and by light electric slip ring by integrated probe
Output photoacoustic signal is excited, and the photoacoustic signal of generation is gathered by the integrated ultrasonic transducer of integrated probe, is then changed by ultrasound
Energy device changes into electric signal and is received by ultrasonic receiver by after light electric slip ring by the coaxial cable of connection transducer, and passes through
Gathered by the second capture card after signal filtering and secondary signal amplifier, then send computer disposal to rebuild light sound spectrogram signal
Picture；
The ultrasonic signal is excited and included with acquisition system：Delayer, impulse ultrasound emitting/receiving, secondary signal are put
Big device, traffic filter and the second capture card, the impulse ultrasound emitting/receiving receive delayer and provide trigger signal
Launch ultrasonic pulse afterwards, the ultrasonic transducer of the probe of integration is transferred to by coaxial cable and by light electric slip ring, make to surpass
Sonic transducer produces ultrasonic wave, is detected and received the ultrasonic wave for reflecting to blood vessel, and ultrasonic transducer is by reflectance ultrasound
Signal is converted into electric signal again by coaxial cable, light electric slip ring, ultrasound emission receiver, by secondary signal amplifier, then
Computer is transferred to by the second capture card by traffic filter, Vascular Ultrasonography image is obtained by image reconstruction.
Used as preferred technical scheme, transmission fluorescence light source and photo-acoustic excitation light source and fluorescence reception have used fiber optic loop
Shape device simultaneous transmission so that the reception of fluorescence carries out avoiding spatial light from disturbing in a fiber, and improves fluorescence reception efficiency, should
The port2 of optical fiber circulator is divided to for two sections are connected by light electric slip ring, and light electric slip ring is fixed with rotating stepper motor, so as to realize
Rotation.
As preferred technical scheme, fluorescent dye selection Cy7, the optical maser wavelength that described pulse laser is launched
750nm；
The pulse laser be semiconductor laser, solid state laser, dye laser or gas laser, output
The wave-length coverage of pulse laser is 400nm~2500nm, and pulse width is 5ns~50ns.
Used as preferred technical scheme, the frequency range of the ultrasound pulse transmission/receiver transmitting ultrasonic signal is
20MHz~50MHz, receive ultrasonic signal frequency range be 1KHz~75MHz, the signal amplifier can amplification frequency be
5-75MHz, gain amplifier is 10-60dB, and signaling rate wave filter is bandpass filter, a width of 5-50MHz of passband.
Used as preferred technical scheme, the integrated probe has been internally integrated high-frequency transducer, high frequency ultrasound
The dominant frequency of transducer is 50MHZ, and with a width of 80%, the frequency range for launching ultrasonic signal is 20MHz~50MHz, receives ultrasound
The frequency range of signal or photoacoustic signal is 1KHz~75MHz.
Used as preferred technical scheme, described optical fiber circulator port3 mouthfuls through end after light electric slip ring through grin lens
With focused on after metallic-membrane plating reflector after lateral 90 ° of light extractions fluorescence is carried out to blood vessel and photoacoustic signal is excited, described optical fiber,
Grin lens and metallic-membrane plating reflector and high-frequency transducer are together placed on external diameter for 1.0mm internal diameters are the medical stainless of 0.5mm
In steel pipe；
The optical fiber circulator port2 mouthfuls of optical fiber, ultrasonic transducer holding wire both pass through medical moment of torsion coil, medical moment of torsion
Coil one end is mechanically connected with light electric slip ring, and the other end is mechanically connected with medical stainless steel pipe, and electric rotating machine passes through light electric slip ring
The rotation of fixed moment of torsion coil is driven, so as to drive fluorescence-optoacoustic in medical stainless steel titanium tube and medical stainless steel pipe-super
The rotation of sound Three models excites collection signal.
Used as preferred technical scheme, the moment of torsion coil and the medical stainless steel pipe being connected with moment of torsion coil are placed
In medical catheter, medical catheter is fixing device, and seal wire drives medical stainless steel pipe to rotate in the catheter, constitutes rotating dress
Put, the effect of conduit is not eccentric when ensureing that seal wire rotates, the whirligig is placed in realizes integration on advance/recession platform
Probe in intravascular movable, the whirligig with advance/recession platform collectively forms rotation/advance/recession platform.
Used as preferred technical scheme, the rotation/advance/recession platform is by horizontal direction stepper motor and axial direction
Stepper motor is constituted, and horizontal direction stepper motor band moving platform completes advance/recession function, the synchronization of axial direction stepper motor
Wheel belt is mechanically connected with light electric slip ring, and lead and the light electric slip ring of ultrasonic transducer are electrically connected, and light electric slip ring outlet connects super
Acoustical signal emitting/receiving, signal is above-mentioned smooth electric slip ring, super by being input into the second capture card after amplifier, traffic filter
Acoustical signal emitting/receiving, signal amplifier, traffic filter, the second capture card be electrical connection, when stepper motor passes through
When synchronizing wheel drives light electric slip ring to rotate, realize by 360 ° of rotations of probe of silk-guiding strip movement and motor-driven integrative.
Used as preferred technical scheme, the synchronizing signal that pulse laser is produced triggers the first capture card and second and adopts respectively
Truck, while the synchronizing signal is allowed to produce electric signal by triggering ultrasound emission receiver after delayer time delay, by light
By the ultrasonic transducer ultra-sonic on integrated probe after electric slip ring.
In order to reach above-mentioned second purpose, the present invention uses following technical scheme：
The method that the present invention is imaged using multi-modality imaging device, comprises the steps：
(1) excite：The device is positioned over Ink vessel transfusing, computer controls pulse laser produces laser, exciting light warp
Cross optical fiber circulator port1 mouthfuls enter by port2 mouthfuls go out by light electric slip ring have integrated probe excite respectively should and optoacoustic
Signal；The synchronization of pulse laser simultaneously triggers ultrasound emission/receiver generation ultrasound, ultrasound hair after being activated through time delay
/ receiver transmitting electric signal is penetrated, is converted electrical signals into by the integrated ultrasonic transducer of integrated probe by light electric slip ring super
Acoustic signals；
(2) data acquisition：The fluorescence signal of generation by above-mentioned integrated probe receive by after light electric slip ring by optical fiber
Port2 mouthfuls of circulator enters and is gathered by port3 feeding photomultipliers, and fluorescence signal is converted into telecommunications by photomultiplier
Number, by being gathered by the first capture card after the first signal amplifier and send into computer；Photoacoustic signal is connect by ultrasonic transducer
Receive, and photoacoustic waves signal be converted into electric signal, by the coaxial wire that is connected with ultrasonic transducer by light electric slip ring after
Received by ultrasound emission/receiver, then sent into by the second capture card by after secondary signal amplifier and traffic filter
Computer；The ultrasonic signal of return is received by ultrasonic transducer, and ultrasonic signal is converted into electric signal, by with ultrasonic transduction
The connected coaxial wire of device is received by after light electric slip ring by ultrasound emission/receiver, is then amplified by secondary signal
Computer is sent into by the second capture card after device and traffic filter；
(3) after the fluorescence-optoacoustic-ultrasonic signal data acquisition of blood vessel a certain position is completed, computer controls rotation step
Stepper motor works, and rotating stepper motor drives runner assembly, runner assembly to drive the rotor of light electric slip ring to rotate, and light electric slip ring turns
The rotational band movement and motor-driven integrative probe of son is rotated, so as to carry out data acquisition to the next position of blood vessel, until integrated probe is complete
Into 360 ° of rotations, so as to complete the data acquisition in a certain section of blood vessel；After completing the data acquisition in a certain section of blood vessel, meter is manipulated
Calculation machine makes translation stepper motor work, and translation stepper motor drives translation platform, translation platform to drive integrated probe translation, from
And data acquisition is carried out to the next section of blood vessel；
(4) image reconstruction：The data that computer will be collected are used for fluoroscopic image, photoacoustic image, the reconstruction of ultrasonoscopy.
The present invention compared with prior art, has the following advantages that and beneficial effect：
1. the present invention realizes fluorescence imaging, the three kinds of integrations of intravascular imaging method of photoacoustic imaging and ultrasonic imaging,
Detection program is simplified, detection difficulty is reduced, it is possible to achieve three kinds of imaging methods work simultaneously.
2. the present invention can simultaneously obtain the acoustic impedance of vascular tissue, optical absorption, optical scattering, the thickness of plaque within blood vessels
The information of degree and component, can more accurately diagnose vascular plaque.
3. rotation sweep pattern of the invention can obtain 360 ° of information of blood vessel, and sensitivity is high, good resolution, can
Realize three kinds of controls of imaging pattern.
4. simple structure of the present invention, compact, it is easy to accomplish, integrated probe size is small, fully meets for tiny blood vessels
Or lesion blocks the detection of blood vessel.
Brief description of the drawings
Fig. 1 is Ink vessel transfusing fluorescence-optoacoustic-supersonic imaging device schematic diagram；
Fig. 2 is optical fiber circulator schematic diagram, laser by port 1 enter it is fashionable can only have 2 mouthfuls of light extractions of port, when laser by
2 mouthfuls of port enter it is fashionable can only be by 3 mouthfuls of light extractions of port.
Drawing reference numeral explanation：1st, computer；2nd, pulse laser；3rd, the first optical filter；4th, collimater；5th, the first optical fiber coupling
Clutch；6th, optical fiber circulator；7th, delayer；8th, ultrasound emission/receiver；9th, light electric slip ring；10th, integrated probe；11st, revolve
Turn/advance/recession platform；12nd, traffic filter；13rd, the first signal amplifier；14th, the second capture card；15th, the second optical fiber coupling
Clutch；16th, the second optical filter；17th, photomultiplier；18th, secondary signal amplifier；19th, the first capture card.
Specific embodiment
With reference to embodiment and accompanying drawing, the present invention is described in further detail, but embodiments of the present invention are not limited
In this.
Embodiment
As shown in figure 1, present embodiment discloses a kind of Ink vessel transfusing fluorescence-optoacoustic-ultrasound multi-modality imaging device, including calculate
Machine 1, fluorescence excitation and acquisition system, photoacoustic signal are excited and excited and acquisition system and one with acquisition system, ultrasonic signal
Change probe 10, the integrated probe is fixed on rotation/translation platform 11 by light electric slip ring 9；Ink vessel transfusing fluorescent exciting
Same light source is used with photo-acoustic excitation light, and Laser Transmission and collection are carried out by optical fiber circulator；
Wherein, the fluorescence excitation includes with acquisition system：Pulse laser 2, the first optical filter 3, collimater 4, first
Fiber coupler 5, optical fiber circulator 6, light electric slip ring 9, integrated probe 10, the second fiber coupler 15, optical filter 16, photoelectricity
The signal amplifier 18 of multiplier tube (PMT) 17, first and the first capture card 9；The computer produces signal excitation pulse laser
Device produces laser, and the first fiber coupler is passed through by optical fiber circulator port1 by collimater after being filtered by the first optical filter
Mouth goes out into port2 mouthfuls and is exported for fluorescence excitation by integrated probe by light electric slip ring, is excited the fluorescence for producing by one
Bodyization probe is received and gone out by the through optical fiber circulator port2 mouthful entrance and by optical fiber circulator port3 mouthfuls by light electric slip ring
Two fiber couplers couple and PMT are sent into after being filtered by the second optical filter and detect, PMT is converted into telecommunications by fluorescence signal is received
Number by being gathered by the first capture card after signal amplifier and send into computer disposal and rebuild fluoroscopic image, as shown in Figure 2；
The photoacoustic signal is excited and included with acquisition system：Pulse laser 2, the second optical filter 3, collimater 4, the first light
Fine coupler 5, optical fiber circulator 6, light electric slip ring 9, integrated probe 10, ultrasound emission receiver 8, traffic filter 12,
Binary signal amplifier 13, the second capture card 14；The pulse laser be excited generation pulse laser after pass through by optical filter
Gone out into port2 mouthfuls by optical fiber circulator port1 mouthfuls and by light by the first fiber coupler by collimater after optical filtering
Electric slip ring is excited by integrated probe output photoacoustic signal, and the photoacoustic signal of generation is by the integrated ultrasonic transducer of integrated probe
Collection, then by ultrasonic transducer change into electric signal by connection transducer coaxial cable by after light electric slip ring by ultrasound
Receiver is received, and by being gathered by the second capture card after signal amplification and filtering, then send computer disposal weight by signal
Build photoacoustic image；
The ultrasonic signal is excited and included with acquisition system：Delayer 7, ultrasound emission/receiver 8, light electric slip ring 9,
Bodyization probe 10, signal amplifier 12, the capture card 14 of traffic filter 13 and second, the impulse ultrasound emitting/receiving
Receive after delayer provides trigger signal and launch ultrasonic pulse, integration is transferred to by coaxial cable and by light electric slip ring
The ultrasonic transducer of probe, makes ultrasonic transducer produce ultrasonic wave, and the ultrasonic wave for reflecting is detected and received to blood vessel,
Reflected ultrasonic is converted into electric signal again by coaxial cable, light electric slip ring, ultrasound emission receiver, warp by ultrasonic transducer
Signal amplifier is crossed, then computer is transferred to by the second capture card by traffic filter, obtaining blood vessel by image reconstruction surpasses
Acoustic image.
In the present embodiment, the Ink vessel transfusing fluorescence-optoacoustic-ultrasound multi-modality imaging device and method, transmission fluorescence light source and
Photo-acoustic excitation light source and fluorescence reception have used an optical fiber circulator simultaneous transmission so that the reception of fluorescence is entered in a fiber
Row avoids spatial light from disturbing, and can very well improve fluorescence reception efficiency, and the port2 of the optical fiber circulator is divided to for two sections by photoelectricity
Slip ring is connected, and light electric slip ring is fixed with rotating stepper motor, so as to realize rotation
In the present embodiment, the optical maser wavelength of described pulse laser is 750nm；
The pulse laser be semiconductor laser, solid state laser, dye laser or gas laser, output
The wave-length coverage of pulse laser is 400nm~2500nm, and pulse width is 5ns~50ns；
The frequency range of the ultrasound pulse transmission/receiver transmitting ultrasonic signal is 20MHz~50MHz, receives ultrasound
The frequency range of signal be 1KHz~75MHz, the signal amplifier can amplification frequency be 5-75MHz, gain amplifier is 10-
60dB, signaling rate wave filter is bandpass filter, a width of 5-50MHz of passband.
In the Ink vessel transfusing fluorescence-optoacoustic-ultrasound multi-modality imaging device, the moment of torsion coil and it is connected with moment of torsion coil
Medical stainless steel pipe be placed in medical catheter, medical catheter is fixing device, and seal wire drives medical stainless steel pipe leading
Rotated in pipe, constitute whirligig, the effect of conduit be it is not eccentric when ensureing that seal wire rotates, the whirligig be placed in advance/
Integrated probe in intravascular movable, the whirligig and the/recession common structure of platform that advances are realized on recession platform
Into rotation/advance/recession platform.
In the Ink vessel transfusing fluorescence-optoacoustic-ultrasound multi-modality imaging device, the rotation/advance/recession platform is by level side
Constituted to stepper motor and axial direction stepper motor, horizontal direction stepper motor band moving platform completes advance/recession function, axle
Mechanically connected to the synchronizing wheel belt and light electric slip ring of direction stepper motor, lead and the light electric slip ring of ultrasonic transducer electrically connect
Connect, light electric slip ring outlet connects ultrasonic signal emission/receiver, signal is adopted by input second after amplifier, traffic filter
Truck, above-mentioned smooth electric slip ring, ultrasonic signal emission/receiver, signal amplifier, traffic filter, the second capture card are electricity
Gas connection, when stepper motor drives light electric slip ring to rotate by synchronizing wheel, realize passing through the probe of silk-guiding strip movement and motor-driven integrative
360 ° of rotations.
Ink vessel transfusing fluorescence-optoacoustic-ultrasound multi-modality imaging the device, the synchronizing signal that pulse laser is produced is triggered respectively
First capture card and the second capture card, while the synchronizing signal is allowed to by triggering ultrasound emission receiver after delayer time delay
Produce electric signal, by after light electric slip ring by the ultrasonic transducer ultra-sonic on integrated probe.
The method that described multi-modality imaging device is imaged, comprises the steps：
(1) excite：The device is positioned over Ink vessel transfusing, computer controls pulse laser produces laser, exciting light warp
Cross optical fiber circulator port1 mouthfuls enter by port2 mouthfuls go out by light electric slip ring have integrated probe excite respectively should and optoacoustic
Signal；The synchronization of pulse laser simultaneously triggers ultrasound emission/receiver generation ultrasound, ultrasound hair after being activated through time delay
/ receiver transmitting electric signal is penetrated, is converted electrical signals into by the integrated ultrasonic transducer of integrated probe by light electric slip ring super
Acoustic signals；
(2) data acquisition：The fluorescence signal of generation by above-mentioned integrated probe receive by after light electric slip ring by optical fiber
Port2 mouthfuls of circulator enters and is gathered by port3 feedings PMT, and fluorescence signal is converted into electric signal by PMT, by amplifier
Computer is gathered and sends into by the first capture card afterwards；Photoacoustic signal is received by ultrasonic transducer, and photoacoustic waves signal is converted
It is electric signal, is received by ultrasound emission/receiver by after light electric slip ring by the coaxial wire being connected with ultrasonic transducer,
Then computer is sent into by the second capture card by after signal amplifier and traffic filter；The ultrasonic signal of return is by ultrasound
Transducer is received, and ultrasonic signal is converted into electric signal, by the coaxial wire that is connected with ultrasonic transducer by photoelectricity
Received by ultrasound emission/receiver after slip ring, then by after signal amplifier and traffic filter by the second capture card
Feeding computer；
(3) after the fluorescence-optoacoustic-ultrasonic signal data acquisition of blood vessel a certain position is completed, computer controls rotation step
Stepper motor works, and rotating stepper motor drives runner assembly, runner assembly to drive the rotor of light electric slip ring to rotate, and light electric slip ring turns
The rotational band movement and motor-driven integrative probe of son is rotated, so as to carry out data acquisition to the next position of blood vessel, until integrated probe is complete
Into 360 ° of rotations, so as to complete the data acquisition in a certain section of blood vessel；After completing the data acquisition in a certain section of blood vessel, meter is manipulated
Calculation machine makes translation stepper motor work, and translation stepper motor drives translation platform, translation platform to drive integrated probe translation, from
And data acquisition is carried out to the next section of blood vessel；
(4) image reconstruction：The data that computer will be collected are used for fluoroscopic image, photoacoustic image, the reconstruction of ultrasonoscopy.
Above-described embodiment is the present invention preferably implementation method, but embodiments of the present invention are not by above-described embodiment
Limitation, it is other it is any without departing from Spirit Essence of the invention and the change, modification, replacement made under principle, combine, simplification,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (10)
1. a kind of Ink vessel transfusing fluorescence-optoacoustic-ultrasound multi-modality imaging device, it is characterised in that including computer, fluorescence excitation and adopt
Collecting system, photoacoustic signal excite with acquisition system, ultrasonic signal excite with acquisition system and integrated probe, it is endovascular
Fluorescence imaging exciting light and photoacoustic imaging exciting light use same light source, and carry out Laser Transmission by optical fiber circulator and adopt
Collection；
Wherein, the fluorescence excitation includes with acquisition system：Pulse laser, the first optical filter, collimater, the first fiber coupling
Device, optical fiber circulator, light electric slip ring, the second fiber coupler, the second optical filter, photomultiplier, the first signal amplifier with
And first capture card；The computer produces signal excitation pulse laser to produce laser, by being passed through after the first optical filter optical filtering
Collimater is crossed to be gone out into port2 mouthfuls by optical fiber circulator port1 mouthfuls by the first fiber coupler and by light electric slip ring by one
Bodyization probe output is used for fluorescence excitation, and the fluorescence for being excited to produce is received by light electric slip ring through fiber annular by integrated probe
Device port2 mouthfuls enters and to be gone out coupled by the second fiber coupler and filtered by the second optical filter by optical fiber circulator port3 mouthfuls
Feeding photomultiplier detection afterwards, photomultiplier is converted into electric signal by the first signal amplifier by fluorescence signal is received
Computer disposal is gathered and sent into by the first capture card afterwards and rebuilds fluoroscopic image；
The photoacoustic signal is excited and included with acquisition system：Pulse laser, the first optical filter, collimater, the first fiber coupling
Device, optical fiber circulator, light electric slip ring, ultrasound emission receiver, traffic filter, secondary signal amplifier and the second collection
Card；The pulse laser be excited generation pulse laser after pass through by the first optical filter filter after pass through by collimater
First fiber coupler is gone out by optical fiber circulator port1 mouthfuls into port2 mouthfuls and is exported by integrated probe by light electric slip ring
Photoacoustic signal is excited, and the photoacoustic signal of generation is gathered by the integrated ultrasonic transducer of integrated probe, then by ultrasonic transducer
Electric signal is changed into be received by ultrasonic receiver by after light electric slip ring by the coaxial cable of connection transducer, and by signal
Gathered by the second capture card after filtering and secondary signal amplifier, then send computer disposal to rebuild photoacoustic image signal；
The ultrasonic signal is excited and included with acquisition system：Delayer, impulse ultrasound emitting/receiving, secondary signal amplifier,
Traffic filter and the second capture card, the impulse ultrasound emitting/receiving are received after delayer provides trigger signal and sent out
Ultrasonic pulse is penetrated, the ultrasonic transducer of the probe of integration is transferred to by coaxial cable and by light electric slip ring, make ultrasonic transduction
Device produces ultrasonic wave, and the ultrasonic wave for reflecting is detected and received to blood vessel, and ultrasonic transducer turns reflected ultrasonic
Electric signal is turned to again by coaxial cable, light electric slip ring, ultrasound emission receiver, by secondary signal amplifier, then by letter
Number wave filter is transferred to computer by the second capture card, and Vascular Ultrasonography image is obtained by image reconstruction.
2. Ink vessel transfusing fluorescence-optoacoustic-ultrasound multi-modality imaging device according to claim 1, it is characterised in that transmission fluorescence light
Source and photo-acoustic excitation light source and fluorescence reception have used optical fiber circulator simultaneous transmission so that the reception of fluorescence is entered in a fiber
Row avoids spatial light from disturbing, and improves fluorescence reception efficiency, and the port2 of the optical fiber circulator is divided to for two sections by light electric slip ring
Connection, light electric slip ring is fixed with rotating stepper motor, so as to realize rotation.
3. Ink vessel transfusing fluorescence-optoacoustic-ultrasound multi-modality imaging device according to claim 1, it is characterised in that fluorescent dye is selected
Select Cy7, the optical maser wavelength 750nm that described pulse laser is launched；
The pulse laser is semiconductor laser, solid state laser, dye laser or gas laser, the pulse of output
The wave-length coverage of laser is 400nm~2500nm, and pulse width is 5ns~50ns.
4. Ink vessel transfusing fluorescence-optoacoustic-ultrasound multi-modality imaging device according to claim 1, it is characterised in that the ultrasonic arteries and veins
The frequency range for rushing emitting/receiving transmitting ultrasonic signal is 20MHz~50MHz, and the frequency range for receiving ultrasonic signal is
1KHz~75MHz, the signal amplifier can amplification frequency be 5-75MHz, gain amplifier is 10-60dB, signaling rate filtering
Device is bandpass filter, a width of 5-50MHz of passband.
5. Ink vessel transfusing fluorescence-optoacoustic-ultrasound multi-modality imaging device according to claim 1, it is characterised in that the integration
That pops one's head in has been internally integrated high-frequency transducer, and the dominant frequency of high-frequency transducer is 50MHZ, and with a width of 80%, transmitting is super
The frequency range of acoustical signal is 20MHz~50MHz, and the frequency range for receiving ultrasonic signal or photoacoustic signal is 1KHz~75MHz.
6. Ink vessel transfusing fluorescence-optoacoustic-ultrasound multi-modality imaging device according to claim 1, it is characterised in that the fiber optic loop
Port2 mouthfuls of shape device is through end after light electric slip ring through lateral 90 ° of light extractions pair after focusing after grin lens and metallic-membrane plating reflector
Blood vessel carries out fluorescence and photoacoustic signal is excited, described optical fiber, grin lens and metallic-membrane plating reflector and high-frequency transducer one
It is same to be placed on external diameter for 1.0mm internal diameters in the medical stainless steel pipe of 0.5mm；
The optical fiber circulator port2 mouthfuls of optical fiber, ultrasonic transducer holding wire both pass through medical moment of torsion coil, medical moment of torsion coil
One end is mechanically connected with light electric slip ring, and the other end is mechanically connected with medical stainless steel pipe, and electric rotating machine is driven by light electric slip ring
The rotation of fixed moment of torsion coil, so as to drive the fluorescence-optoacoustic-ultrasound three in medical stainless steel titanium tube and medical stainless steel pipe
The pattern rotation of kind excites collection signal.
7. Ink vessel transfusing fluorescence-optoacoustic-ultrasound multi-modality imaging device according to claim 6, it is characterised in that the torque wire
Circle and the medical stainless steel pipe being connected with moment of torsion coil are placed in medical catheter, and medical catheter is fixing device, seal wire
Drive medical stainless steel pipe to rotate in the catheter, constitute whirligig, the effect of conduit is not eccentric, institute when ensureing that seal wire rotates
State whirligig and be placed on advance/recession platform and realize integrated probe in intravascular movable, the whirligig with
The platform that advances/drop back collectively forms rotation/advance/recession platform.
8. Ink vessel transfusing fluorescence-optoacoustic-ultrasound multi-modality imaging device according to claim 7, it is characterised in that the rotation/
The platform that advances/drop back is made up of horizontal direction stepper motor and axial direction stepper motor, and horizontal direction stepper motor drives flat
Platform completes/recession function of advancing, and synchronizing wheel belt and the light electric slip ring of axial direction stepper motor are mechanically connected, ultrasonic transducer
Lead and light electric slip ring be electrically connected, light electric slip ring outlet connects ultrasonic signal emission/receiver, and signal is by amplifier, letter
The second capture card, above-mentioned smooth electric slip ring, ultrasonic signal emission/receiver, signal amplifier, signal filter are input into after number wave filter
Ripple device, the second capture card be electrical connection, when stepper motor drives light electric slip ring to rotate by synchronizing wheel, realize by leading
360 ° of rotations of probe of silk ribbon movement and motor-driven integrative.
9. Ink vessel transfusing fluorescence-optoacoustic-ultrasound multi-modality imaging device according to claim 1, it is characterised in that pulse laser
The synchronizing signal of generation triggers the first capture card and the second capture card respectively, while after the synchronizing signal is by delayer time delay
Triggering ultrasound emission receiver is allowed to produce electric signal, by being surpassed by the ultrasonic transducer on integrated probe after light electric slip ring
Sound ultrasonic wave.
10. a kind of Ink vessel transfusing fluorescence-optoacoustic-ultrasound multi-modality imaging device using any one of claim 1-9 is carried out
The method of imaging, it is characterised in that comprise the steps：
(1) excite：The device is positioned over Ink vessel transfusing, computer controls pulse laser produces laser, and the exciting light is by light
It is fine circulator port1 mouthfuls enter by port2 mouthfuls go out by light electric slip ring have integrated probe excite respectively should and photoacoustic signal；
The synchronization of pulse laser simultaneously triggers ultrasound emission/receiver generation ultrasound, ultrasound emission/reception after being activated through time delay
Device launches electric signal, and converting electrical signals into ultrasonic wave by the integrated ultrasonic transducer of integrated probe by light electric slip ring believes
Number；
(2) data acquisition：The fluorescence signal of generation by above-mentioned integrated probe receive by after light electric slip ring by fiber annular
Port2 mouthfuls of device enters and is gathered by port3 feeding photomultipliers, and fluorescence signal is converted into electric signal by photomultiplier,
By being gathered by the first capture card after the first signal amplifier and send into computer；Photoacoustic signal is received by ultrasonic transducer,
And photoacoustic waves signal is converted into electric signal, by the coaxial wire that is connected with ultrasonic transducer by being surpassed after light electric slip ring
Sound emission/receiver is received, and then sends into calculating by the second capture card by after secondary signal amplifier and traffic filter
Machine；The ultrasonic signal of return is received by ultrasonic transducer, and ultrasonic signal is converted into electric signal, by with ultrasonic transducer phase
Coaxial wire even is received by after light electric slip ring by ultrasound emission/receiver, then by secondary signal amplifier and
Computer is sent into by the second capture card after traffic filter；
(3) after the fluorescence-optoacoustic-ultrasonic signal data acquisition of blood vessel a certain position is completed, computer controls rotation stepping electricity
Machine works, and rotating stepper motor drives runner assembly, runner assembly to drive the rotor of light electric slip ring to rotate, photoelectricity slip-ring rotor
Rotational band movement and motor-driven integrative probe is rotated, so as to carry out data acquisition to the next position of blood vessel, until integrated probe is completed
360 ° of rotations, so as to complete the data acquisition in a certain section of blood vessel；After completing the data acquisition in a certain section of blood vessel, maneuvering calculation
Machine makes translation stepper motor work, and translation stepper motor drives translation platform, translation platform to drive integrated probe translation, so that
Data acquisition is carried out to the next section of blood vessel；
(4) image reconstruction：The data that computer will be collected are used for fluoroscopic image, photoacoustic image, the reconstruction of ultrasonoscopy.
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