CN106361294B - A kind of intravascular optical coherence tomography-optoacoustic-ultrasound multi-modality imaging apparatus and method - Google Patents
A kind of intravascular optical coherence tomography-optoacoustic-ultrasound multi-modality imaging apparatus and method Download PDFInfo
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Abstract
The invention belongs to blood vessel endoscope imaging fields, disclose a kind of intravascular optical coherence tomography-optoacoustic-ultrasound multi-modality imaging apparatus and method.The device includes, including computer, OCT excitation and acquisition system, photoacoustic signal excitation and acquisition system, ultrasonic signal excitation and acquisition system and integrated probe.The OCT excitation and acquisition system include: PFGA plate, superluminescent diode, isolator, the first fiber coupling, reference arm, line array CCD and the first capture card；The photoacoustic signal excitation includes: pulse laser, diaphragm, the second fiber coupler and doubly clad optical fiber with acquisition system, and the ultrasonic signal excitation and acquisition system include: impulse ultrasound emitting/receiving, signal amplifier, traffic filter and the second capture card；OCT, optoacoustic and ultrasonic three mode blood vessel endoscope imaging systems are incorporated three kinds of imaging patterns and its respective advantage by the present invention, can get many reference amounts physiological function information and multiple dimensioned structural information of blood vessel.
Description
Technical field
The present invention relates to the research field of blood vessel endoscope, in particular to a kind of intravascular optical coherence tomography-light
Sound-ultrasound multi-modality imaging apparatus and method.
Background technique
Cardiovascular and cerebrovascular disease is the higher disease of the present death rate, and the accuracy of blood vessel detection also has higher requirement.
The means of modern medicine detection blood vessel have, including magnetic resonance (MRI) blood vessel imaging and angiographic imaging (IVUS) and intravascular
Optical coherence tomography images (OCT), above several detection means can preferably show the formalness or inner wheel of blood vessel
Exterior feature, but the local detail information of vascular wall and lumen of vessels can not be provided.Intravascular photoacoustic imaging technique is a kind of novel doctor
Imaging technique is learned, cardinal principle is by pulsed laser irradiation tissue, and tissue resorption light generates thermoelastic wave, by surpassing to generation
Sound wave carries out the relevant information that available tissue is imaged.And intravascular photoacoustic imaging technique is endoscopic technique and optics, electricity
The technologies such as sub-, Digital Image Processing continue to develop and the product of fusion.From a kind of unique visual angle, i.e., from internal blood vessel to blood
Pipe section is imaged, and is able to observe that the fine structure for the vascular wall and lumen that other imaging methods can not be observed, very
To structural constituent.Traditional optical vessel based endoscopic imaging principle is all to utilize optical scattering or reflection signal acquisition detection figure
Picture, since light is influenced by medium scatters, the shortcomings that there are penetration depth shallow (mm grades).
Optical coherence tomography (OCT): being an emerging Tomography technology, intravascular OCT can
Precise measurement coronary artery inner membrance and fibrous cap thickness, provide tissue in situ and real-time imaging, greatly strengthen image resolution ratio and
Still OCT's contrast is affected by blood scattering, the lower deep layer signal that cannot identify blood vessel of imaging depth.
Intravascular ultrasound imaging (IVUS) is imaged based on echo of the detection ultrasonic signal in vascular wall, reflects blood
The otherness of tubing acoustic impedance；Intravascular photoacoustic imaging is that the optoacoustic letter generated after pulse laser is absorbed based on detection vascular wall
It number is imaged, reflects the optical absorption difference of vascular tissue.Both technologies are respectively from two parameters of acoustic impedance and light absorption
Upper to provide the information of blood vessel, the imaging depth of two kinds of imaging methods can achieve 10cm or more, therefore both technologies are very suitable
It closes and based endoscopic imaging is carried out to blood vessel.
Intravascular OCT- optoacoustic-ultrasound multi-modality imaging technology combines three kinds of imaging methods, effectively overcomes list
The deficiency of one mode imaging, is capable of providing intravascular many reference amounts, and the information of various dimensions helps to diagnose endovascular patch feelings
Condition.
Application No. is 201210510661.X, patent it is entitled " non-contact photoacoustic and optical coherence tomographic imaging apparatus and
Detection method ", the imaging device and method of a kind of OCT and photoacoustic imaging combination are disclosed, which realizes plane using galvanometer
Two-dimensional scanning, but can not be applied to intravascular.
Application No. is 201010187650.3, patent name is a kind of " intravascular photoacoustic ultrasonic double-mode imaging endoscope dress
Set and its imaging method " document disclose a kind of technology.The technology is anti-using hollow circular ring array ultrasonic sensors and the conical surface
Penetrate mirror, when photoacoustic imaging, pulse laser transmits by optical fiber and emits at light end out, scatters simultaneously on the face of conical reflector
Entire vascular wall is irradiated, photoacoustic signal is excited, the photoacoustic signal generated is received using circle ring array ultrasonic detector；Ultrasonic imaging
When circle ring array ultrasonic detector emit ultrasonic signal, then receive the ultrasonic signal of vasoreflex, probe have photoacoustic imaging and
The performance of ultrasonic imaging.
Its deficiency is that the pulse laser of the technology is expanded in conical reflector, while exciting entire internal blood vessel, required
Laser energy is big；And since pulse laser does not converge, so the resolution ratio of photoacoustic image is bad, the furthermore probe of the device
Using 64 acoustic sensors, the receiving efficiency of single acoustic sensor is bad and structure is complicated.
Application No. is 201210220399.5, patent name is " focusing rotary scanning photoacoustic ultrasound blood vessel endoscope imaging
Device and its imaging method " document disclose a kind of imaging device, using the device carry out photoacoustic ultrasound integration blood vessel
Interior imaging method research.Direct 90 ° of the optical fiber connector of the device go out light, and laser is on divergent irradiation to object under test, and laser does not have
There is convergence, equally exists the poor problem of the resolution ratio of photoacoustic image, and device disclosed in the technology, the coupling of laser and optical fiber
Direct-coupled mode is taken in conjunction, deviation easily occurs during fiber spinning in this way, so as to cause the biography of laser to optical fiber
Defeated efficiency reduces, and directly affects the generation of photoacoustic signal.
Summary of the invention
It is relevant disconnected to provide a kind of intravascular optical for the shortcomings that it is a primary object of the present invention to overcome the prior art and deficiency
Layer imaging-optoacoustic-ultrasound multi-modality imaging device, may be implemented the imaging of OCT- optoacoustic-ultrasound Three models, energy using the device
Enough while intravascular many reference amounts, multiple dimensioned information are obtained, improves the detection accuracy of plaque within blood vessels.
Another object of the present invention is to provide a kind of methods being imaged using above-mentioned imaging device, use the imaging
Method can get endovascular OCT image, photoacoustic image and ultrasound image.
In order to reach above-mentioned first purpose, the invention adopts the following technical scheme:
A kind of device of endovascular optical coherence tomography-optoacoustic-ultrasound multi-modality imaging of the invention, including meter
Calculation machine, OCT excitation and acquisition system, photoacoustic signal excitation and acquisition system, ultrasonic signal excitation and acquisition system and one
Change probe, endovascular optical coherence tomography OCT exciting light and photo-acoustic excitation light use different light sources, and pass through double clad
Optical fiber carries out laser transmission and acquisition；
Wherein, the OCT excitation and acquisition system include: FPGA plate, superluminescent diode, isolator, the first optical fiber coupling
Clutch, reference arm, line array CCD and the first capture card；The FPGA plate generates signal excitation superluminescent diode and generates OCT
Exciting light enters doubly clad optical fiber fibre core for OCT signal by passing through first fiber coupler a part after isolator
Excitation, a part are used as reference arm laser signal, and the laser into doubly clad optical fiber fibre core carries out signal by integrated probe
It excites and acquires OCT signal and returned again along doubly clad optical fiber fibre core, by being acquired after reference arm by line array CCD and being converted into electricity
Then signal send computer acquisition by the first capture card, finally rebuild and obtain intravascular OCT image；
The photoacoustic signal excitation and acquisition system include: pulse laser, diaphragm, the second fiber coupler, Yi Jishuan
Cladded-fiber, the pulse laser be excited generate pass through diaphragm after pulse laser after pass through the second fiber coupler into
Enter the covering of doubly clad optical fiber, then is excited by integrated probe and optoacoustic is acquired by the ultrasonic transducer that integrated probe integrates
Then signal is converted to electric signal by ultrasonic transducer and is passed through after photoelectricity slip ring by the coaxial cable of connection energy converter by ultrasound
Receiver receives, and is acquired after amplifying and filter by signal by the second capture card, then send signal to computer disposal weight
Build photoacoustic image；
The ultrasonic signal excitation includes: impulse ultrasound emitting/receiving, signal amplifier, signal filter with acquisition system
Wave device and the second capture card, the impulse ultrasound emitting/receiving emit ultrasonic pulse after receiving trigger signal, pass through
Coaxial cable is transferred to the ultrasonic transducer of integrated probe, so that ultrasonic transducer is generated ultrasonic wave, detects to blood vessel
And reflected ultrasonic wave is received, ultrasonic transducer converts electric signal using coaxial cable, light for reflected ultrasonic
Electric slip ring, ultrasound emission receiver are transferred to calculating by the second capture card using traffic filter by signal amplifier
Machine obtains Vascular Ultrasonography image by image reconstruction.
It transmits OCT light source as a preferred technical solution, and photo-acoustic excitation light source has used a doubly clad optical fiber simultaneously
The fibre core of transmission, doubly clad optical fiber is single mode transport, is used for transmission OCT exciting light；Outer layer is multimode transmissions, is used for transmission optoacoustic
Exciting light, the double clad are divided into two sections and are connected by photoelectricity slip ring, and photoelectricity slip ring is fixed with rotating stepper motor, to realize rotation
Turn.
The optical maser wavelength that the superluminescent diode is emitted as a preferred technical solution, is 1310nm；
The pulse laser be semiconductor laser, solid state laser, dye laser or gas laser, output
The wave-length coverage of pulse laser is 400nm~2500nm, and pulse width is 5ns~50ns.
The ultrasound pulse transmission/receiver transmitting ultrasonic signal frequency range is as a preferred technical solution,
20MHz~50MHz, receive ultrasonic signal frequency range be 1KHz~75MHz, the signal amplifier can amplification frequency be
5-75MHz, gain amplifier 10-60dB, signaling rate filter are bandpass filter, and passband width is 5-50MHz.
The integrated probe has been internally integrated high-frequency transducer, high frequency ultrasound as a preferred technical solution,
The dominant frequency of energy converter is 50MHZ, and bandwidth 80%, the frequency range for emitting ultrasonic signal is 20 MHz~50MHz, receives ultrasound
The frequency range of signal or photoacoustic signal is 1KHz~75MHz.
The doubly clad optical fiber end focuses it after grin lens and metallic-membrane plating reflector as a preferred technical solution,
Rear side goes out light to 110 °, carries out OCT to vascular wall and photoacoustic signal excites, the doubly clad optical fiber, grin lens and plated film
It is 1.0mm internal diameter is in the round titanium tube of 0.5mm that reflecting mirror and high-frequency transducer are placed on outer diameter together；
The doubly clad optical fiber, ultrasonic transducer signal wire both pass through medical guiding wire, medical guiding wire one end and photoelectricity slip ring
Mechanical connection, the other end and round titanium tube are mechanically connected, and rotating electric machine drives the rotation of fixed seal wire by photoelectricity slip ring, from
And drive OCT- optoacoustic-ultrasound Three models rotation excitation acquisition signal in round titanium tube and round titanium tube.
The medical guiding wire and the titanium tube being connected with medical guiding wire are placed in medical lead as a preferred technical solution,
Guan Zhong, medical catheter are fixed device, and seal wire drives titanium tube to rotate in the catheter, constitute rotating device, and the effect of conduit is to protect
Demonstrate,prove seal wire rotation when it is not eccentric, the rotating device be placed on advance/recession platform realize integrated probe in the blood vessels before
After move, the rotating device and advance/recession platform collectively form rotation/advance/recession platform.
Rotation/advance/recession the platform is by horizontal direction stepper motor and axial direction as a preferred technical solution,
Stepper motor composition, horizontal direction stepper motor band moving platform complete advance/recession function, the synchronization of axial direction stepper motor
Gear and photoelectricity slip ring are mechanically connected, and the lead and photoelectricity slip ring of ultrasonic transducer are electrically connected, and photoelectricity slip ring outlet connects ultrasound
Signal emitting/receiving, signal input the second capture card, above-mentioned photoelectricity slip ring, ultrasound after amplifier, traffic filter
Signal emitting/receiving, signal amplifier, traffic filter, the second capture card are electrical connection, when stepper motor passes through tooth
When wheel drives the rotation of photoelectricity slip ring, realizes and photoacoustic ultrasound 360 ° of rotations of integrated probe are driven by seal wire.
Whole system timing control is as follows as a preferred technical solution, and it is super that computer controls FPGA generation signal excitation
Light emitting diode generates OCT exciting light, collects OCT signal and triggers ultrasound emission/receiver generation ultrasound, ultrasound hair later
Emitter generates synchronous triggering signal simultaneously, and excitation pulse laser generation optoacoustic swashs after which passes through delayer
It shines.
In order to reach above-mentioned second purpose, the invention adopts the following technical scheme:
A kind of method being imaged using multi-modality imaging device of the invention, is included the following steps:
(1) it excites: the device is placed in intravascular, computer control FPGA plate generation signal excitation superluminescent diode
OCT exciting light is generated, by integrated probe excitation OCT letter when which passes through photoelectricity slip ring with the fibre core of doubly clad optical fiber
Number；It collects OCT signal and triggers ultrasound emission/receiver generation ultrasound later, ultrasound emission/receiver emits electric signal, warp
It crosses photoelectricity slip ring and ultrasonic signal is converted electrical signals by the ultrasonic transducer that integrated probe integrates, ultrasonic signal is to blood
Pipe detection；The emitting/receiving generates synchronous triggering signal simultaneously, which passes through excitation pulse after delayer
Laser generates photo-acoustic excitation light, and the exciting light after diaphragm by the inner cladding of doubly clad optical fiber by being passed through after photoelectricity slip ring
By the lateral 110 ° of directive blood vessels of integrated probe, photoacoustic signal is excited；
(2) data acquire: the OCT signal of generation is passed back by the fibre core of above-mentioned doubly clad optical fiber through photoelectricity slip ring later, and
It is acquired by line array CCD, collects OCT signal by the first capture card and be sent into computer；The ultrasonic signal of return is by ultrasonic transducer
Receive, and convert electric signal for ultrasonic signal, by the coaxial wire that is connected with ultrasonic transducer by photoelectricity slip ring it
It is received afterwards by ultrasound emission/receiver, is then sent into and is counted by the second capture card after signal amplifier and traffic filter
Calculation machine；Photoacoustic signal is received by ultrasonic transducer, and converts electric signal for photoacoustic waves signal, by what is be connected with ultrasonic transducer
Then coaxial wire is filtered by being received after photoelectricity slip ring by ultrasound emission/receiver by signal amplifier and signal
Computer is sent by the second capture card after device；
(3) after completing OCT- optoacoustic-ultrasonic signal data acquisition of a certain position of blood vessel, maneuvering calculation machine walks rotation
It works into motor, rotating stepper motor drives runner assembly, and runner assembly drives the rotor rotation of photoelectricity slip ring, and photoelectricity slip ring turns
The rotation of son drives integrated probe rotation, so that data acquisition is carried out to the next position of blood vessel, until integrated probe is complete
It is rotated at 360 °, to complete the data acquisition in a certain section of blood vessel；After the data acquisition for completing a certain section of blood vessel, manipulation meter
Calculation machine makes translation stepper motor work, translation stepper motor driving translation platform, translation platform driving integrated probe translation, from
And data acquisition is carried out to the lower section of blood vessel；
(4) image reconstruction: collected data are used for the reconstruction of OCT image, photoacoustic image, ultrasound image by computer.
Compared with the prior art, the invention has the following advantages and beneficial effects:
1. the present invention realizes OCT image, the integration of three kinds of intravascular imaging methods of photoacoustic imaging and ultrasonic imaging, letter
Detection program is changed, has reduced detection difficulty, three kinds of imaging methods may be implemented and work at the same time.
2. the present invention can obtain the acoustic impedance of vascular tissue simultaneously, optical absorption, optical scattering, plaque within blood vessels thickness
The information such as degree and mechanical property, can diagnose vascular plaque more accurately.
3. rotary scanning mode of the invention can obtain 360 ° of information of blood vessel, and high sensitivity, good resolution can
Realize the control of three kinds of imaging patterns.
4. the configuration of the present invention is simple, compact, it is easy to accomplish, integrated probe size is small, sufficiently meets for tiny blood vessels
Or the detection of lesion blocking blood vessel.
Detailed description of the invention
Fig. 1 is intravascular OCT- optoacoustic-ultrasound multi-modality imaging schematic device；
Fig. 2 is the schematic diagram of integrated probe used in intravascular OCT- optoacoustic-ultrasound multi-modality imaging device.
Drawing reference numeral explanation: 1, computer；2, FPGA plate；3, superluminescent diode；4, isolator；5, the first optical fiber coupling
Clutch；6, reference arm；7, line array CCD；8, the first capture card；9, doubly clad optical fiber bundling device；10, impulse ultrasound transmitting/reception
Device；11, signal amplifier；12, traffic filter；13, the second capture card；14, delayer；15, pulse laser；16, diaphragm；
17, the second fiber coupler；18, photoelectricity slip ring；19, rotation/translation platform；20 integrated probes；21, coaxial wire；
22, doubly clad optical fiber；23, titanium tube；24, grin lens；25, metallic-membrane plating reflector；26, ultrasonic transducer；27, blood vessel sample.
Specific embodiment
Present invention will now be described in further detail with reference to the embodiments and the accompanying drawings, but embodiments of the present invention are unlimited
In this.
Embodiment
As shown in Figure 1, present embodiment discloses a kind of endovascular optical coherence tomography-optoacoustic-ultrasound is multi-modal
The device of imaging, including computer 1, OCT excitation are excited with acquisition system, photoacoustic signal excitation and acquisition system, ultrasonic signal
With acquisition system and integrated probe 20, the integrated probe is fixed on rotation/translation platform 19 by photoelectricity slip ring 18
On；Endovascular optical coherence tomography OCT exciting light and photo-acoustic excitation light use different light sources, and pass through doubly clad optical fiber
Carry out laser transmission and acquisition；
Wherein, the OCT excitation and acquisition system include: FPGA plate 2, superluminescent diode 3, isolator 4, the first optical fiber
Coupler 5, reference arm 6, line array CCD 7 and the first capture card 8；The FPGA plate generates signal excitation superluminescent diode
OCT exciting light is generated, enters doubly clad optical fiber fibre core for OCT by passing through first fiber coupler a part after isolator
The excitation of signal, a part are used as reference arm laser signal, and the laser into doubly clad optical fiber carries out letter by integrated probe
It number excites and acquires OCT signal and returned again along doubly clad optical fiber fibre core, by being acquired and being converted by line array CCD after reference arm
For electric signal, computer acquisition then is sent by the first capture card, finally rebuilds and obtains intravascular OCT image；
Photoacoustic signal excitation and acquisition system include: pulse laser 15, diaphragm 16, the second fiber coupler 17,
And doubly clad optical fiber, the pulse laser, which is excited to generate after pulse laser passes through diaphragm later, passes through the second optical fiber coupling
Clutch enters the covering of doubly clad optical fiber, then is excited by integrated probe and adopted by the ultrasonic transducer that integrated probe integrates
Collect photoacoustic signal, then by ultrasonic transducer be converted to electric signal by connection energy converter coaxial cable by after electric slip ring by
Ultrasonic receiver receives, and is acquired after amplifying and filter by signal by the second capture card, then send signal at computer
Reason rebuilds photoacoustic image；
The ultrasonic signal excitation includes: impulse ultrasound emitting/receiving 10, signal amplifier 11, letter with acquisition system
Number filter 12 and the second capture card 13, are additionally provided with delayer 15 between the traffic filter and pulse laser, described
First fiber coupler and the second fiber coupler carry out the conjunction beam of optical fiber by doubly clad optical fiber bundling device 9, and signal is passed
Pass integrated probe；The impulse ultrasound emitting/receiving emits ultrasonic pulse after receiving trigger signal, by coaxial electrical
Cable is transferred to the ultrasonic transducer of integrated probe, so that ultrasonic transducer is generated ultrasonic wave, is detected and received to blood vessel
Reflected ultrasonic wave, ultrasonic transducer by reflected ultrasonic be converted into electric signal using coaxial cable, photoelectricity slip ring,
Ultrasound emission receiver is transferred to computer by the second capture card using traffic filter by signal amplifier, by figure
Vascular Ultrasonography image is obtained as rebuilding.
As shown in Fig. 2, the integrated probe 20 is saturating including coaxial wire 21, doubly clad optical fiber 22, titanium tube 23, grin
Mirror 24 and metallic-membrane plating reflector 25, ultrasonic transducer 26 are arranged on blood vessel sample 27 when the integrated probe 20 uses；
Go out light for lateral 110 ° after the doubly clad optical fiber end focuses after grin lens and metallic-membrane plating reflector, vascular wall is carried out
OCT and photoacoustic signal excitation, the doubly clad optical fiber, grin lens and metallic-membrane plating reflector and high-frequency transducer are together
It is in the round titanium tube of 0.5mm that be placed on outer diameter, which be 1.0mm internal diameter,；The doubly clad optical fiber, ultrasonic transducer signal wire both pass through
Medical guiding wire, medical guiding wire one end and photoelectricity slip ring are mechanically connected, and the other end and round titanium tube are mechanically connected, and rotating electric machine passes through
Photoelectricity slip ring drives the rotation of fixed seal wire, to drive OCT- optoacoustic-ultrasound three in round titanium tube and round titanium tube
Kind mode rotation excitation acquisition signal.
In addition, the integrated probe has been internally integrated high-frequency transducer, the dominant frequency of high-frequency transducer is
50MHZ, bandwidth 80%, the frequency range for emitting ultrasonic signal is 20MHz~50MHz, receives ultrasonic signal or photoacoustic signal
Frequency range be 1KHz~75MHz.
In the present embodiment, transmits OCT light source and photo-acoustic excitation light source has used a doubly clad optical fiber simultaneous transmission, double-contracting
The fibre core of layer optical fiber is single mode transport, is used for transmission OCT exciting light；Outer layer is multimode transmissions, is used for transmission OCT excitation and returns
Light, the double clad are divided into two sections and are connected by photoelectricity slip ring, and photoelectricity slip ring is fixed with rotating stepper motor, to realize rotation.
In the present embodiment, the optical maser wavelength that the superluminescent diode is emitted is 1310nm；
The pulse laser be semiconductor laser, solid state laser, dye laser or gas laser, output
The wave-length coverage of pulse laser is 400nm~2500nm, and pulse width is 5ns~50ns；
The ultrasound pulse transmission/receiver transmitting ultrasonic signal frequency range is 20MHz~50MHz, receives ultrasound
The frequency range of signal is 1KHz~75MHz, the signal amplifier can amplification frequency be 5-75 MHz, gain amplifier is
10-60dB, signaling rate filter are bandpass filter, and passband width is 5-50MHz.
The medical guiding wire and the titanium tube being connected with medical guiding wire are placed in medical catheter, and medical catheter is to fix
Device, seal wire drive titanium tube to rotate in the catheter, constitute rotating device, and the effect of conduit is not eccentric when being guarantee seal wire rotation,
The rotating device, which is placed on advance/recession platform, realizes the back-and-forth motion of integrated probe in the blood vessels, the rotating device
Rotation/advance/recession platform is collectively formed with advance/recession platform.
Rotation/advance/recession the platform is made of horizontal direction stepper motor and axial direction stepper motor, level side
Advance/recession function is completed to stepper motor band moving platform, the synchromesh gear and photoelectricity slip ring of axial direction stepper motor are mechanical
Connection, the lead and photoelectricity slip ring of ultrasonic transducer are electrically connected, and photoelectricity slip ring outlet connects ultrasonic signal emission/receiver, believes
Number by amplifier, the second capture card, above-mentioned photoelectricity slip ring, ultrasonic signal emission/receiver, letter are inputted after traffic filter
Number amplifier, traffic filter, the second capture card are electrical connection, when stepper motor drives photoelectricity slip ring to rotate by gear
When, it realizes and photoacoustic ultrasound 360 ° of rotations of integrated probe is driven by seal wire.
According to the description above it is found that whole system timing control is as follows, it is super that computer controls FPGA generation signal excitation
Light emitting diode generates OCT exciting light, collects OCT signal and triggers ultrasound emission/receiver generation ultrasound, ultrasound hair later
Emitter generates synchronous triggering signal simultaneously, and excitation pulse laser generation optoacoustic swashs after which passes through delayer
It shines.
A kind of method being imaged using the multi-modality imaging device of the present embodiment, is included the following steps:
(1) it excites: the device is placed in intravascular, computer control FPGA plate generation signal excitation superluminescent diode
OCT exciting light is generated, by integrated probe excitation OCT letter when which passes through photoelectricity slip ring with the fibre core of doubly clad optical fiber
Number；It collects OCT signal and triggers ultrasound emission/receiver generation ultrasound later, ultrasound emission/receiver emits electric signal, warp
It crosses photoelectricity slip ring and ultrasonic signal is converted electrical signals by the ultrasonic transducer that integrated probe integrates, ultrasonic signal is to blood
Pipe detection；The emitting/receiving generates synchronous triggering signal simultaneously, which passes through excitation pulse after delayer
Laser generates photo-acoustic excitation light, and the exciting light after diaphragm by the inner cladding of doubly clad optical fiber by being passed through after photoelectricity slip ring
By the lateral 110 ° of directive blood vessels of integrated probe, photoacoustic signal is excited；
(2) data acquire: the OCT signal of generation is passed back by the fibre core of above-mentioned doubly clad optical fiber through photoelectricity slip ring later, and
It is acquired by line array CCD, collects OCT signal by the first capture card and be sent into computer；The ultrasonic signal of return is by ultrasonic transducer
Receive, and convert electric signal for ultrasonic signal, by the coaxial wire that is connected with ultrasonic transducer by photoelectricity slip ring it
It is received afterwards by ultrasound emission/receiver, is then sent into and is counted by the second capture card after signal amplifier and traffic filter
Calculation machine；Photoacoustic signal is received by ultrasonic transducer, and converts electric signal for photoacoustic waves signal, by what is be connected with ultrasonic transducer
Then coaxial wire is filtered by being received after photoelectricity slip ring by ultrasound emission/receiver by signal amplifier and signal
Computer is sent by the second capture card after device；
(3) after completing OCT- optoacoustic-ultrasonic signal data acquisition of a certain position of blood vessel, maneuvering calculation machine walks rotation
It works into motor, rotating stepper motor drives runner assembly, and runner assembly drives the rotor rotation of photoelectricity slip ring, and photoelectricity slip ring turns
The rotation of son drives integrated probe rotation, so that data acquisition is carried out to the next position of blood vessel, until integrated probe is complete
It is rotated at 360 °, to complete the data acquisition in a certain section of blood vessel；After the data acquisition for completing a certain section of blood vessel, manipulation meter
Calculation machine makes translation stepper motor work, translation stepper motor driving translation platform, translation platform driving integrated probe translation, from
And data acquisition is carried out to the lower section of blood vessel；
(4) image reconstruction: collected data are used for the reconstruction of OCT image, photoacoustic image, ultrasound image by computer.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (8)
1. a kind of device of endovascular optical coherence tomography-optoacoustic-ultrasound multi-modality imaging, which is characterized in that including
Computer, OCT excitation and acquisition system, photoacoustic signal excitation and acquisition system, ultrasonic signal excitation and acquisition system, Yi Jiyi
Bodyization probe, endovascular optical coherence tomography OCT exciting light and photo-acoustic excitation light use different light sources, and pass through double-contracting
Layer optical fiber carries out laser transmission and acquisition；
Wherein, OCT excitation and acquisition system include: FPGA plate, superluminescent diode, isolator, the first fiber coupler,
Reference arm, line array CCD and the first capture card；The FPGA plate generates signal excitation superluminescent diode and generates OCT excitation
Light, the excitation for entering doubly clad optical fiber fibre core for OCT signal by passing through first fiber coupler a part after isolator,
A part is used as reference arm laser signal, and the laser into doubly clad optical fiber fibre core carries out signal excitation simultaneously by integrated probe
OCT signal is acquired to return along doubly clad optical fiber fibre core again, by acquiring and being converted into electric signal by line array CCD after reference arm,
Then computer acquisition is sent by the first capture card, finally rebuilds and obtains intravascular OCT image；
The photoacoustic signal excitation and acquisition system include: pulse laser, diaphragm, the second fiber coupler and double clad
Optical fiber, the pulse laser, which is excited to generate after pulse laser passes through diaphragm later, passes through the entrance pair of the second fiber coupler
The covering of cladded-fiber, then excited by integrated probe and optoacoustic letter is acquired by the ultrasonic transducer that integrated probe integrates
Number, electric signal is then converted to by the coaxial cable of connection energy converter by being connect after photoelectricity slip ring by ultrasound by ultrasonic transducer
It receives device to receive, and is acquired after amplifying and filter by signal by the second capture card, then send computer disposal to rebuild signal
Photoacoustic image；
Ultrasonic signal excitation and acquisition system include: impulse ultrasound emitting/receiving, signal amplifier, traffic filter,
And second capture card, the impulse ultrasound emitting/receiving emits ultrasonic pulse after receiving trigger signal, by coaxial electrical
Cable is transferred to the ultrasonic transducer of integrated probe, so that ultrasonic transducer is generated ultrasonic wave, is detected and received to blood vessel
Reflected ultrasonic wave, ultrasonic transducer by reflected ultrasonic be converted into electric signal using coaxial cable, photoelectricity slip ring,
Ultrasound emission receiver is transferred to computer by the second capture card using traffic filter by signal amplifier, by figure
Vascular Ultrasonography image is obtained as rebuilding,
Go out light for lateral 110 ° after the doubly clad optical fiber end focuses after grin lens and metallic-membrane plating reflector, to vascular wall
Carry out OCT and photoacoustic signal excitation, the doubly clad optical fiber, grin lens and metallic-membrane plating reflector and high-frequency transducer
It is in the round titanium tube of 0.5mm that be placed on outer diameter together, which be 1.0mm internal diameter,；
The doubly clad optical fiber, ultrasonic transducer signal wire both pass through medical guiding wire, and medical guiding wire one end and photoelectricity slip ring are mechanical
Connection, the other end and round titanium tube are mechanically connected, and rotating electric machine drives the rotation of fixed seal wire by photoelectricity slip ring, thus band
Move OCT- optoacoustic-ultrasound Three models rotation excitation acquisition signal in round titanium tube and round titanium tube；
The specific steps of data acquisition are as follows:
The OCT signal of generation is passed back by the fibre core of above-mentioned doubly clad optical fiber through photoelectricity slip ring later, and is acquired by line array CCD, is adopted
Collect OCT signal and computer is sent by the first capture card；The ultrasonic signal of return is received by ultrasonic transducer, and ultrasonic wave is believed
Number be converted into electric signal, by the coaxial wire that is connected with ultrasonic transducer by after photoelectricity slip ring by ultrasound emission/reception
Device receives, and is then sent into computer by the second capture card after signal amplifier and traffic filter；Photoacoustic signal is by surpassing
Sonic transducer receives, and converts electric signal for photoacoustic waves signal, passes through light by the coaxial wire being connected with ultrasonic transducer
It is received after electric slip ring by ultrasound emission/receiver, then by the second acquisition after signal amplifier and traffic filter
Card is sent into computer；
After completing OCT- optoacoustic-ultrasonic signal data acquisition of a certain position of blood vessel, maneuvering calculation machine makes rotating stepper motor
Work, rotating stepper motor drive runner assembly, and runner assembly drives the rotor rotation of photoelectricity slip ring, and photoelectricity slip-ring rotor turns
It is dynamic to drive integrated probe rotation, so that data acquisition is carried out to the next position of blood vessel, until integrated probe completes 360 °
Rotation, to complete the data acquisition in a certain section of blood vessel；After the data acquisition for completing a certain section of blood vessel, maneuvering calculation machine makes
Translation stepper motor work, translation stepper motor driving translation platform, translation platform driving integrated probe translation, thus to blood
It manages next section and carries out data acquisition.
2. the device of endovascular optical coherence tomography-optoacoustic-ultrasound multi-modality imaging according to claim 1,
It is characterized in that, transmits OCT light source and photo-acoustic excitation light source has used a doubly clad optical fiber simultaneous transmission, the fibre of doubly clad optical fiber
Core is single mode transport, is used for transmission OCT exciting light；Outer layer is multimode transmissions, is used for transmission photo-acoustic excitation light, which is divided into
Two sections are connected by photoelectricity slip ring, and photoelectricity slip ring is fixed with rotating stepper motor, to realize rotation.
3. the device of endovascular optical coherence tomography-optoacoustic-ultrasound multi-modality imaging according to claim 1,
It is characterized in that, the optical maser wavelength that the superluminescent diode is emitted is 1310nm, and band is wider than 100nm；
The pulse laser is semiconductor laser, solid state laser, dye laser or gas laser, the pulse of output
The wave-length coverage of laser is 400nm~2500nm, and pulse width is 5ns~50ns.
4. the device of endovascular optical coherence tomography-optoacoustic-ultrasound multi-modality imaging according to claim 1,
It is characterized in that, the ultrasound pulse transmission/receiver transmitting ultrasonic signal frequency range is 20MHz~50MHz, receives ultrasound
The frequency range of signal be 1KHz~75MHz, the signal amplifier can amplification frequency be 5-75MHz, gain amplifier 10-
60dB, signaling rate filter are bandpass filter, and passband width is 5-50MHz.
5. the device of endovascular optical coherence tomography-optoacoustic-ultrasound multi-modality imaging according to claim 1,
It is characterized in that, the integrated probe has been internally integrated high-frequency transducer, and the dominant frequency of high-frequency transducer is
50MHZ, bandwidth 80%, the frequency range for emitting ultrasonic signal is 20MHz~50MHz, receives ultrasonic signal or photoacoustic signal
Frequency range be 1KHz~75MHz.
6. the device of endovascular optical coherence tomography-optoacoustic-ultrasound multi-modality imaging according to claim 1,
It is characterized in that, the medical guiding wire and the titanium tube being connected with medical guiding wire are placed in medical catheter, and medical catheter is solid
Determine device, seal wire drives titanium tube to rotate in the catheter, constitutes rotating device, and the effect of conduit is not inclined when guaranteeing seal wire rotation
The heart, the rotating device, which is placed on advance/recession platform, realizes the back-and-forth motion of integrated probe in the blood vessels, the rotating dress
It sets and collectively forms rotation/advance/recession platform with advance/recession platform.
7. the device of endovascular optical coherence tomography-optoacoustic-ultrasound multi-modality imaging according to claim 6,
It is characterized in that, the rotation/advance/recession platform is made of horizontal direction stepper motor and axial direction stepper motor, horizontal
Direction stepper motor band moving platform completes advance/recession function, the synchromesh gear and photoelectricity slip ring machine of axial direction stepper motor
Tool connection, the lead and photoelectricity slip ring of ultrasonic transducer are electrically connected, and photoelectricity slip ring outlet connects ultrasonic signal emission/receiver,
Signal by amplifier, input the second capture card after traffic filter, above-mentioned photoelectricity slip ring, ultrasonic signal emission/receiver,
Signal amplifier, traffic filter, the second capture card are electrical connection, when stepper motor drives the rotation of photoelectricity slip ring by gear
When turning, realizes and photoacoustic ultrasound 360 ° of rotations of integrated probe are driven by seal wire.
8. the device of endovascular optical coherence tomography-optoacoustic-ultrasound multi-modality imaging according to claim 1,
It is characterized in that, whole system timing control is as follows, and computer controls FPGA generation signal excitation superluminescent diode generation OCT and swashs
It shines, collects OCT signal and trigger ultrasound emission/receiver generation ultrasound later, which generates synchronous touching simultaneously
It signals, excitation pulse laser generates photo-acoustic excitation light after which passes through delayer.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106691396A (en) * | 2017-02-28 | 2017-05-24 | 华南师范大学 | Intravascular fluorescent-photoacoustic-ultrasonic multi-mode imaging device and method |
| CN107411708A (en) * | 2017-05-22 | 2017-12-01 | 上海交通大学 | A kind of optical coherence tomography and photoacoustic imaging bimodal endoscope |
| JP7181198B2 (en) * | 2017-06-29 | 2022-11-30 | テルモ株式会社 | diagnostic imaging catheter |
| JP7158796B2 (en) * | 2017-12-07 | 2022-10-24 | 株式会社アドバンテスト | Optical ultrasonic measuring device, method, program, recording medium |
| CN108198174B (en) * | 2017-12-28 | 2021-11-19 | 中科微光医疗研究中心(西安)有限公司 | Cardiovascular IVOCT and IVUS automatic registration method and device |
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| CN108464817A (en) * | 2018-03-28 | 2018-08-31 | 深圳英美达医疗技术有限公司 | A kind of double-mode imaging system and its imaging method |
| CN108618758A (en) * | 2018-04-27 | 2018-10-09 | 华南师范大学 | Intravascular photoacoustic-optical coherence tomography-near infrared light multi-modality imaging apparatus and method |
| CN109363636B (en) * | 2018-10-29 | 2021-08-06 | 中国科学院上海技术物理研究所 | Detection method based on coaxial time domain resolution photoacoustic imaging |
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| CN110051432A (en) * | 2019-05-27 | 2019-07-26 | 北京航空航天大学 | A method of laser thrombolysis in the blood vessel is realized under optical coherence tomography guidance |
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| CN111419149A (en) * | 2020-03-13 | 2020-07-17 | 上海应用技术大学 | Multi-mode endoscope and endoscopic imaging system |
| CN111387947A (en) * | 2020-04-07 | 2020-07-10 | 中国科学院苏州生物医学工程技术研究所 | Multi-mode microscopic endoscopic imaging device and method |
| CN111667447A (en) * | 2020-06-05 | 2020-09-15 | 全景恒升（北京）科学技术有限公司 | Intravascular image fusion method and system and image acquisition device |
| CN113080870A (en) * | 2021-04-12 | 2021-07-09 | 北京航空航天大学 | Imaging system |
| CN113080871B (en) * | 2021-04-12 | 2022-09-16 | 北京航空航天大学 | Imaging system |
| CN113081043B (en) * | 2021-04-12 | 2022-07-05 | 北京航空航天大学 | Ultrasonic imaging detector |
| CN113545809B (en) * | 2021-06-01 | 2023-11-28 | 广东省科学院健康医学研究所 | Intravascular laser speckle-photoacoustic-ultrasonic imaging device and method |
| CN113495054B (en) * | 2021-09-09 | 2021-11-19 | 广州永士达医疗科技有限责任公司 | OCT (optical coherence tomography) guide wire transmission synchronism detection method, device and system |
| CN114010151B (en) * | 2021-09-16 | 2023-11-24 | 南方科技大学 | Photoacoustic ultrasound multi-mode imaging system |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100455253C (en) * | 2007-03-29 | 2009-01-28 | 浙江大学 | Endoscopic imaging system in bulk optics biopsy spectral coverage OCT |
| US8764666B2 (en) * | 2008-10-28 | 2014-07-01 | The Regents Of The University Of California | Ultrasound guided optical coherence tomography, photoacoustic probe for biomedical imaging |
| CN103385758B (en) * | 2013-07-22 | 2015-12-09 | 深圳先进技术研究院 | A kind of intravascular photoacoustic ultrasonic double-mode imaging system and formation method thereof |
| CN104224117B (en) * | 2014-09-10 | 2017-06-30 | 南京航空航天大学 | It is a kind of optical spectrum encoded confocal imaging method and system to be cooperateed with optical coherence tomography |
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