CN101912250B - Intravascular photoacoustic and ultrasonic double-mode imaging endoscope device and imaging method thereof - Google Patents

Intravascular photoacoustic and ultrasonic double-mode imaging endoscope device and imaging method thereof Download PDF

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CN101912250B
CN101912250B CN2010101876503A CN201010187650A CN101912250B CN 101912250 B CN101912250 B CN 101912250B CN 2010101876503 A CN2010101876503 A CN 2010101876503A CN 201010187650 A CN201010187650 A CN 201010187650A CN 101912250 B CN101912250 B CN 101912250B
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photoacoustic
ultrasonic
mode
imaging
ultrasound
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CN101912250A (en
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杨思华
袁毅
邢达
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华南师范大学
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Abstract

The invention discloses an intravascular photoacoustic and ultrasonic double-mode imaging endoscope device and an imaging method thereof. The device comprises a photoacoustic excitation light source generator, a micro photoacoustic and ultrasonic double-mode endoscope probe, an ultrasonic signal exciting and acquiring subassembly and a computer, wherein the micro photoacoustic and ultrasonic double-mode endoscope probe consists of an incident optical fiber, a hollow annular array ultrasonic detector, a coated conical surface high reflector, a tube shell and a PVC tube; the incident optical fiber is connected with the photoacoustic excitation light source generator and passes through the hollow annular array ultrasonic detector; the hollow annular array ultrasonic detector is connected with the ultrasonic signal exciting and acquiring subassembly through a coaxial data transmission line; the coated conical surface high reflector is fixed in the tube shell; and the tube shell is fixedlyconnected with the outlet of the optical fiber so that the output laser is reflected circularly on the coated conical surface outwards and matched with the hollow annular array ultrasonic detector. The device and the method can realize imaging of a photoacoustic and ultrasonic double-mode endoscope and can be applied to the photoacoustic and ultrasonic double-mode imaging in vessels or micro cavities.

Description

一种血管内光声超声双模成像内窥镜装置及其成像方法 An intravascular ultrasound endoscope apparatus and the photoacoustic imaging method dual mode imaging

技术领域 FIELD

[0001] 本发明属于无损测试测量技术,特别涉及一种将光声超声双模成像技术用于血管内结构成像的内窥成像装置及其成像方法。 [0001] The present invention belongs to non-destructive test and measurement technology, and particularly relates to a dual-mode ultrasonic photoacoustic imaging techniques for endoscopic imaging device and an imaging method for imaging the vascular structure.

背景技术 Background technique

[0002] 内窥镜,是一种多学科通用的工具,其功能是能对弯曲管道深处探查,能观察不能直视到的部位,能在密封空腔内观察内部空间结构与状态,能实现远距离观察与操作。 [0002] The endoscope is a multidisciplinary versatile tool, its function is able to probe the depths of the curved duct, can not look directly at the site to observe, in the internal space can be sealed cavity structure state observation, can observation and realize remote operation. 目前的常用的光学内窥镜主要是是光、机、电一体的NDT仪器,它分为三类系列产品:第一类,硬性内窥镜系列;第二类,纤维内窥镜系列;第三类,电子视频内窥镜系列。 Current endoscopes are mainly used in light optical, mechanical, electrical integration of NDT instrumentation, it is divided into three series: the first category, the rigid endoscope series; second, fiberscope series; first three categories, electronic video endoscope series. 硬性内窥镜系列其工作原理是利用转像透镜光学技术来传送影像,并由光导纤维提供传光照明。 The rigid endoscope series which works by using a relay lens optical image transfer techniques, by providing an optical fiber transmission lighting. 纤维内窥镜系列其工作原理是由高品质韵传像纤维来传送图像,通过目镜直接观察。 Fiberscope series which works like a high-quality fiber Yun transmitting the image transfer, direct observation through the eyepiece. 电子视频内窥镜系列是运用超小型电荷耦合器件(CXD)技术制造电子视频内窥镜产品。 Electronic videoscope series is the use of ultra-small charge-coupled device (CXD) technology to produce electronic video endoscopy products. 上述三类内窥技术其基本原理都是利用光学散射或者反射信号获取检测图像,由于受介质散射影响大,存在穿透深度浅(〜mm级)的缺点。 The basic principle in the above three types of endoscopic techniques are scattered or reflected by an optical detection signal acquiring images, due to the large effect of scattering medium, the presence of shallow penetration depth (level ~mm) disadvantages.

[0003] 超声内窥成像对组织的穿透深度可达30mm以上,它反映了吸收体的声阻抗参数。 [0003] endoscopic ultrasound imaging of the tissue penetration depth of up to 30mm or more parameters which reflects the acoustic impedance of the absorber. 光声成像作为近年来发展起来的一种新型成像方法,它反映了吸收体的光吸收参数。 Photoacoustic imaging as a new imaging method developed in recent years, it reflects the light absorbing absorber parameters. 本专利开展光声超声双模内窥成像方法研究,研制光声超声双成像内窥系统,既可以反映吸收体的声阻抗参数,又可以反映吸收体的光吸收参数,对于推动我国自主研制新型内窥装置有着积极的推进意义。 This patent study carried out endoscopic ultrasound imaging methods in the photoacoustic dual-mode, dual-developed within the photoacoustic imaging endoscopic ultrasound system, not only can reflect the acoustic impedance parameters of the absorber, and can reflect the light absorption parameters absorber, promoting China's own development of new the endoscopic propulsion device has a positive meaning.

发明内容 SUMMARY

[0004] 本发明的首要目的在于提供一种血管内光声超声双模内窥成像装置。 [0004] The primary object of the present invention to provide an image forming apparatus Endoscope photoacoustic an intravascular ultrasound dual mode.

[0005] 本发明的另一目的在于提供一种根据上述装置进行血管内光声超声双模内窥成像的方法;该方法操作简单,检测精度高;该方法利用脉冲激光或幅度调制的连续光源激发产生光致热弹超声信号,通过测量该信号可以重建出检测样品的光吸收分布图像;通过采集超声回波,重建出检测样品的声阻抗差异图像;通过光声超声双成像来确定吸收体结构的改变;所述内窥成像主要适用于血管内部部位的成像。 [0005] Another object of the present invention is to provide a method for the dual-mode intravascular ultrasound photoacoustic imaging endoscope apparatus according to the above; the method is simple, high precision; The method uses a continuous light source or amplitude modulation of the pulsed laser photo-excitation of elastic heat ultrasound signal can be reconstructed light absorption distribution image is detected by measuring a sample of the signal; determined by the photoacoustic imaging ultrasound bis absorber; by acquiring ultrasonic echo, an acoustic impedance difference image reconstruction test sample structural changes; endoscopic imaging is mainly applied to the inner portion of intravascular imaging.

[0006] 为了实现上述目的,本发明采用以下技术方案:一种血管内光声超声双模成像内窥镜装置,该装置包括光声激发光源发生器、微型光声超声双模成像内窥探头、超声信号激发与采集组件和计算机;所述光声激发光源发生器、微型光声超声双模成像内窥探头、超声信号激发与采集组件和计算机依次电气相连;所述微型光声超声双模成像内窥探头由入射光纤、中空圆环阵列超声探测器、镀膜锥面高反射镜、管壳和医用级聚氯乙烯管(PVC管)组成;所述入射光纤与光声激发光源发生器相连,并穿过中空圆环阵列超声探测器;所述中空圆环阵列超声探测器通过同轴数据传输线与超声信号激发与采集组件相连;所述医用级聚氯乙烯管套在入射光纤、中空圆环阵列超声探测器、镀膜锥面高反射镜和管壳的外面;所述管壳将镀膜锥面高反射镜和入射光纤相连 [0006] To achieve the above object, the present invention employs the following technical solutions: A photoacoustic intravascular ultrasound endoscope dual mode imaging device, the apparatus comprising an optical acoustic excitation light generator, the first snoop miniature dual-mode ultrasound imaging photoacoustic ultrasound signal excitation and acquisition component and a computer; the photoacoustic excitation light generator, the dual-mode ultrasonic micro photoacoustic imaging snoop head, and is electrically connected to the ultrasonic excitation signal acquisition component and a computer sequentially; the miniature dual-mode ultrasonic photoacoustic snoop the head imaged by the incident optical fiber, hollow annular array ultrasonic probe, the tapered surface coating the high reflection mirror, bulb, and medical grade PVC pipe (PVC pipe) composition; optical fiber connected to said incident acoustic excitation light source and the light generator and through the hollow annular array ultrasonic probe; said hollow annular array coaxial with the ultrasound probe through the data transmission line connected to the ultrasound excitation signal acquisition component; the medical grade PVC tube over the input fiber, a hollow circle ring array ultrasound probe, the outer tapered surface coating the high reflection mirror and a tube housing; said cartridge connecting tapered surface coating the high reflection mirror and an incident optical fiber 接,镀膜锥面高反射镜位于管壳内,而管壳固定在入射光纤的末端,镀膜锥面高反射镜的锥面正对着入射光纤;所述光声超声双模成像内窥镜的直径为1. 3mm〜1. 4mm。 Then, the tapered surface coating the high reflection mirror is located within the envelope, and the envelope of the input optical fiber fixed to the end, a high reflection mirror coating tapered surface tapered surface facing the input fiber; the dual-mode ultrasonic photoacoustic imaging endoscope diameter of 1. 3mm~1. 4mm.

[0007] 所述血管内光声超声双模成像内窥镜装置应用于光声和超声双模同时成像或单模切换成像。 [0007] The photoacoustic intravascular ultrasound endoscope apparatus is applied to a dual mode imaging photoacoustic and ultrasound imaging at the same time the dual-mode or single mode switching image.

[0008] 所述光声激发光源发生器为短脉冲激光器,光声激发光源发生器产生的激光由单模光纤接合输出,所述光纤数值孔径为0. 22,所述激光的波长为400〜2500nm,脉宽范围为5ns 〜50ns ο [0008] The light source generator acoustic excitation generator excitation wavelength laser light source by engaging a single mode fiber output fiber is the numerical aperture of 0.22, the laser is a short pulse laser photoacoustic of 400~ 2500nm, a pulse width in the range of 5ns ~50ns ο

[0009] 所述光声激发光源发生器产生输出的激光通过入射光纤后,经镀膜锥面高反射镜向外反射成圆环形激发光,与中空圆环阵列超声探测器接收方向匹配,实现360度圆周的光声信号同轴激发和接收模式。 [0009] The acoustic excitation light source outputted laser light generator through the incident optical fiber, tapered surface by coating the high reflection mirror reflecting the excitation light outwardly in circular, matching the ultrasound probe and the receiving direction of the array of hollow ring, to achieve photoacoustic signal 360 degree circle coaxial excitation and reception mode.

[0010] 所述激光被镀膜锥面高反射镜反射后在中空圆环阵列超声探测器的法线方向上形成圆环形状光斑。 [0010] After coating of the laser is highly reflecting mirror formed tapered annular shape of the spot in the normal direction of the hollow annular array ultrasound probe.

[0011] 所述中空圆环超声探测器含有64阵元,内径为0. 2〜0. 4mm,外径为1. 0〜1. 2mm, 主频为20MHz〜40MHz。 The [0011] the ultrasound probe comprising a hollow cylindrical ring 64 element, an inner diameter of 0. 2~0. 4mm, outer diameter of 1. 0~1. 2mm, clocked 20MHz~40MHz.

[0012] 所述医用级聚氯乙烯管的末端为封闭的圆滑结构。 End of the [0012] Medical grade polyvinyl chloride tube is closed smooth structure.

[0013] 光纤和镀膜锥面高反射镜通过套管连接为一个整体。 [0013] The tapered optical fibers and coating the high reflection mirror is connected via cannula as a whole.

[0014] 光声探测器套在光纤外侧,贴附在PVC管的内壁。 [0014] In the photoacoustic probe sheath around the optical fiber, attached to the inner wall of the PVC pipe.

[0015] 所述计算机中带有采集控制软件和图像重建软件。 [0015] with the acquisition and control computer software and image reconstruction software.

[0016] 一种根据上述的血管内光声超声双模成像内窥镜装置进行内窥成像的方法,包括以下操作步骤: [0016] A method of imaging an endoscopic blood vessel within the above dual mode imaging photoacoustic ultrasound endoscope apparatus, comprising the following steps:

[0017] (1)将微型光声超声双模成像内窥探头插入待测血管或腔体内; [0017] (1) The micro photoacoustic ultrasound test head insertion snoop vessel or cavity within the dual mode imaging;

[0018] (2)光声激发:将光声激发光源发生器产生的脉冲激光通过入射光纤耦合,经镀膜锥面高反射镜侧向入射到待测血管壁或腔体壁,激发产生光声信号; [0018] (2) Light acoustic excitation: the acoustic excitation pulse laser light generated by the light generator input optical fiber coupled, by coating the high reflection mirror side tapered surface to be measured enters the vessel wall or cavity wall, the excitation photoacoustic signal;

[0019] (3)光声采集:中空圆环阵列超声探测器接收到光声信号后,经超声信号激发与采集组件通过同轴数据传输线进行数据采集,再将数据传输并储存到带有采集控制软件和图像重建软件的计算机中; [0019] (3) collecting the photoacoustic: a hollow annular array ultrasonic probe receives the photoacoustic signal, the ultrasonic signal excitation and acquisition component data acquisition through a coaxial transmission line data, and then transfer the data collected and stored with and image reconstruction software computer control software;

[0020] (4)超声激发和采集:光声信号采集完毕后,超声激发与采集组件先对中空圆环阵列超声探测器中的一个超声振元进行激发,中空圆环阵列超声探测器接收超声回波信号后,经超声激发与采集组件通过同轴数据传输线进行数据采集,然后超声激发与采集组件依次对中空圆环阵列超声探测器中的下一个超声振元进行激发和数据采集;最后将数据传输并储存到带有采集控制软件和图像重建软件的计算机中; [0020] (4) an ultrasonic excitation and acquisition: the photoacoustic signal acquisition is completed, the ultrasonic excitation and acquisition component of a first hollow annular array ultrasonic probe in the ultrasonic vibrator element is excited, a hollow annular array ultrasonic probe receives ultrasound after the echo signals excited by ultrasound data acquisition and acquisition component through a coaxial transmission line data, and then sequentially excite the ultrasound transducer element at a hollow annular array ultrasonic probe in the ultrasonic excitation and data acquisition and acquisition component; finally and data transmission to a computer with stored control software and acquisition of image reconstruction software;

[0021] (5)数据处理:对采集的数据进行处理,通过MATLAB程序利用滤波反投影算法进行图像重建,得到待测血管或腔体内壁的光声(光吸收分布)和超声图像。 [0021] (5) Data processing: data acquisition process is performed using a filtered back projection image reconstruction algorithm MATLAB program to obtain a blood vessel or measured in vivo photoacoustic chamber wall (light absorption profile) and ultrasound images.

[0022] 步骤(¾、步骤C3)和步骤(4)可以合并成一个步骤,即光声激发、光声采集与超声激发和采集同时进行,中空圆环阵列超声探测器同时接收超声回波和光声信号,根据两种信号的接收时间差异,实现光声超声的同时成像。 [0022] Step (¾, step C3) and step (4) may be combined into one step, i.e., the photoacoustic excitation, collection and ultrasonic acoustic excitation light and collection simultaneously, while the hollow annular array ultrasonic probe and a light receiving ultrasound echo acoustic signal, in accordance with the time difference between the two received signals to achieve simultaneous photoacoustic ultrasound imaging.

[0023] 步骤(3)所述计算机内有数据采集控制平台和图像重建的MATLAB程序。 [0023] Step (3) The data acquisition control program MATLAB internet and a computer for image reconstruction. 成像时利用小角度滤波反投影得到光声二维图像,可方便快速的对血管实现横向的光声层析成像和超声图像。 When using a small angle filtered back-projection image to obtain a two-dimensional photoacoustic image can be easily and quickly implemented transverse photoacoustic tomography and ultrasound images of the blood vessels. [0024] 本发明的作用原理是:光声激发光源产生脉冲激光(波长、脉宽和重复频率可根据需要选择),经入射光纤侧向反射至血管壁,血管病变与周围正常部位对光吸收差异导致光致热弹超声信号被中空圆环阵列超声探测器接收;接收的信号由信号采集系统采集并传输到带有采集控制软件和图像重建软件的计算机做后处理;通过滤波反投影成像算法重建出血管的光声图像。 [0024] Mechanisms of this invention are: acoustic excitation light source generates a pulsed laser (wavelength, pulse width and repetition frequency may need to select), reflected by the incident optical fiber to the vessel wall side, vascular lesion and surrounding normal light absorbing portion difference causes photo Thermoelastic ultrasonic signal is received a hollow annular array ultrasound probe; receiving a signal capture and transfer to the computer with the acquisition and control software and image reconstruction software to do the processing by the signal acquisition system; imaging algorithm by filtered backprojection reconstructed photoacoustic image of blood vessels. 超声激发源产生的超声,血管病变与周围正常部位的声阻抗差异导致不同强度的超声反射信号,由微型中空超声圆环阵列探测器接收,接收的超声信号由信号采集系统采集并传输到带有采集控制软件和图像重建软件的计算机做后处理;通过滤波反投影成像算法重建出血管的超声图像。 An ultrasonic excitation source generates ultrasonic acoustic impedance difference vascular lesions and surrounding normal sites results in different intensities of ultrasonic reflection signal received by the micro hollow annular array ultrasonic probe, the ultrasonic signal received by the acquisition and transmission to a signal acquisition system having software and computer acquisition and control software to do after image reconstruction process; vascular ultrasound image reconstructed by filtered back-projection imaging algorithm. 或者光激发与超声激发能够同时进行,圆环阵列探测器同时接收超声回波和光声信号,根据两种信号的接收时间差异,对超声回波和光声信号进行采集,采集到的信号通过带有采集控制软件和图像重建软件的计算机做后处理。 Or the excitation light can be performed simultaneously with ultrasonic excitation, the annular array of detectors simultaneously receive ultrasound echo and the photoacoustic signal, according to the time difference between the two received signals, and the ultrasonic echo photoacoustic signal acquisition, signal collected with acquisition and control software and computer image reconstruction software to do after treatment. 本发明适用于微小血管内部结构的成像,从而可以对血管内部结构进行光吸收参数和声阻抗参数的双参数评价。 The present invention is applicable to the imaging of the internal structure of the tiny blood vessels, which can be two-parameter evaluation parameters light absorbing acoustic impedance parameters on the internal structure of the blood vessel.

[0025] 与现有技术相比,本发明具有如下的有益效果: [0025] Compared with the prior art, the present invention has the following advantages:

[0026] 1)本发明利用反映光吸收分布和声阻抗差异原理的光声超声双模内窥成像系统对血管内部结构进行成像。 [0026] 1) the use of the present invention reflects light absorbing internal structure of vascular imaging distributed endoscopic ultrasound imaging system within the photoacoustic principle dual-mode acoustic impedance difference. 重建的光声超声图像不仅仅反映血管内组织的光学吸收差异, 还反映组织的声学特性的变化。 Photoacoustic ultrasound image reconstruction intravascular tissue reflect not only differences in optical absorption, also reflects changes in the acoustic properties of the tissue.

[0027] (2)本发明的关键部件为微型光声超声双模内窥探头,集前端带有镀膜锥面高反射镜的入射光纤、微型中空超声圆环阵列探测器、和PVC管于一体,所用部件体积小,适于内窥成像,使用方便。 [0027] (2) The key components of the present invention is the dual-mode ultrasonic photoacoustic micro snoop head, sets the front end with a tapered surface coating of the high reflection mirror enters an optical fiber, ultrasonic micro hollow annular array detector, and a PVC pipe in one , the member of small volume, suitable for endoscopic imaging, and easy to use.

附图说明 BRIEF DESCRIPTION

[0028] 图1是实施例1所述血管内光声超声双模内窥成像装置的结构示意图,其中1为微型光声超声双模成像内窥探头,2为光声激发光源发生器,3为超声信号激发与采集组件,4为带有采集控制软件和图像重建软件的计算机,5为入射光纤,6为中空圆环阵列超声探测器,7为镀膜锥面高反射镜,8为管壳,9为PVC管,10为同轴数据传输线,11为中空圆环阵列超声探测器的振元。 [0028] FIG. 1 is a schematic structural diagram of an image forming apparatus endoscopic Example 1 inner vessel ultrasonic photoacoustic dual-mode embodiment, wherein the first microcomputer 1 is a snoop dual-mode ultrasonic photoacoustic imaging, acoustic excitation light source 2 is a generator, 3 ultrasound signals excited and acquisition component, with a computer 4 and image reconstruction software acquisition and control software, the incident optical fiber 5, 6 is a hollow annular array ultrasonic probe, the tapered surface 7 for the high reflection mirror coating, shell and tube 8 9 is a PVC pipe, 10 is a data transmission line coaxial, hollow element 11 of annular array transducer of the ultrasound probe.

[0029] 图2是实施例1所述光纤管套以及镀膜锥面高反射镜连接的结构示意图,5为入射光纤,7为镀膜锥面高反射镜,8为管壳。 [0029] FIG. 2 is a schematic structural diagram and a ferrule tapered surface coating connected to the high reflection mirror described in Example 1, an incident optical fiber 5, the tapered surface 7 to the high reflection mirror coating, shell and tube 8.

[0030] 图3(a)是实施例1所述中空圆环阵列超声探测器套在光纤外侧的结构示意图,5 为入射光纤,6为中空圆环阵列超声探测器,11为中空圆环阵列超声探测器的振元。 [0030] FIG. 3 (a) is an embodiment of the hollow annular array ultrasound probe 1 in a schematic view of the outer jacket of the optical fiber, the incident optical fiber 5, 6 is a hollow annular array ultrasonic probe 11 is a hollow annular array transducer element ultrasound probe.

[0031] 图3(b)是实施例1所述光声超声双模成像内窥探头横截面结构示意图,5为入射光纤,9为PVC管,11为中空圆环阵列超声探测器的振元。 [0031] FIG. 3 (b) is a schematic cross-sectional structure of the first embodiment of the snoop Example 1 photoacoustic dual-mode ultrasound imaging, the incident optical fiber 5, 9 of PVC pipe, 11 is a hollow annular array transducer of the ultrasound probe element .

[0032] 图4是本发明血管内光声超声双模内窥成像装置用于血管管腔横截面的断层图像;其中,a为血管管腔结构图;b为血管管腔内外壁的光声截面图;c为血管管腔内外壁的超声截面图。 [0032] FIG. 4 is an endoscopic ultrasonic photoacoustic imaging devices within a blood vessel of the present invention for dual-mode within the vessel lumen cross section of the tomographic image; wherein, a is a configuration diagram of the vessel lumen; B photoacoustic inner and outer walls of the vessel lumen sectional view; C is a sectional view of an ultrasonic vessel lumen inner and outer walls.

具体实施方式 Detailed ways

[0033] 下面结合实施例及附图对本发明作进一步详细的描述,但本发明的实施方式不限于此。 [0033] and the following description in conjunction with the accompanying drawings of the embodiments of the present invention will be further detailed embodiment, the embodiment of the present invention is not limited thereto. [0034] 实施例1 :一种血管内光声超声双模内窥成像装置(结构示意图如图1所示) [0034] Example 1: an in photoacoustic intravascular ultrasound endoscope dual mode imaging apparatus (structure shown in Figure 1.)

[0035] 该装置包括微型光声超声双模成像内窥探头1、光声激发光源发生器2、超声信号激发与采集组件3和带有采集控制软件和图像重建软件的计算机4 ;所述微型光声超声双模成像内窥探头1、光声激发光源发生器2、超声信号激发与采集组件3和带有采集控制软件和图像重建软件的计算机4依次电气相连;所述微型光声超声双模成像内窥探头1由入射光纤5、中空圆环阵列超声探测器6、镀膜锥面高反射镜7、管壳8和医用级聚氯乙烯管(PVC管)9组成,所述入射光纤5与光声激发光源发生器2相连,所述中空圆环阵列超声探测器6通过同轴数据传输线10与超声信号激发与采集系统3相连;所述PVC管9套在入射光纤5、中空圆环阵列超声探测器6、镀膜锥面高反射镜7和管壳8的外面;所述镀膜锥面高反射镜7固定在管壳8内,而管壳8固定在入射光纤5的末端,镀膜锥面高反射镜7 [0035] The apparatus comprises an inner miniature dual-mode ultrasound imaging photoacoustic snoop head 1, the excitation light source sound generator 2, and the ultrasonic signal excitation and acquisition component 3 with the acquisition and control computer software and image reconstruction software to 4; said microcomputer the dual-mode ultrasound imaging photoacoustic snoop head 1, the photoacoustic excitation light generator 2, an ultrasonic excitation signal is electrically connected sequentially acquisition component 4 and 3 with the acquisition and control computer software and image reconstruction software; the micro-bis ultrasonic photoacoustic the die head 1 by the image forming snoop incident optical fiber 5, a hollow annular array ultrasonic probe 6, a high reflection mirror coating tapered surface 7, the envelope 8 and a medical grade polyvinyl chloride tubes (PVC tubes) 9 composed of the input optical fiber 5 acoustic excitation light source coupled to generator 2, the hollow annular array ultrasonic probe 610 and ultrasonic excitation signal acquisition system connected to a data transmission through a coaxial cable 3; 9 PVC pipe sleeve in said incident optical fiber 5, a hollow cylindrical ring array ultrasound probe 6, a high reflection mirror coating conical surface 7 and 8 of the outer envelope; said tapered surface coating the high reflection mirror 7 is fixed in the tubular housing 8, and the envelope 8 fixed to the end 5 of the input optical fiber, film cone high surface mirror 7 锥面正对着入射光纤5 (镀膜锥面高反射镜、管壳和入射光纤的连接如图2所示);所述中空圆环阵列超声探测器6套在入射光纤5的外侧;所述PVC管9的末端为封闭的圆滑结构。 An incident optical fiber 5 facing tapered surface (tapered surface connected to the high reflection mirror coating, the bulb and the input optical fiber shown in FIG. 2); said hollow annular array ultrasonic probe in the outer sleeve 6 of optical fiber 5 is incident; the PVC pipe end 9 is closed smooth structure. 中空圆环阵列超声探测器套在光纤外侧的结构示意图可以如图3(a)所示;光声超声双模成像内窥探头横截面结构示意图可以如图3(b)所示。 An annular array of hollow structural diagram of the ultrasound probe can be set around the optical fiber shown in FIG 3 (a) below; the dual-mode ultrasound imaging photoacoustic snoop head shown a schematic cross-sectional configuration may be as shown in FIG 3 (b).

[0036] 实施例2 : [0036] Example 2:

[0037] 应用实施例1所述装置实现血管管腔横截面的光声和超声内窥成像 The endoscopic imaging [0037] Application Example 1 the cross-section of the lumen of blood vessels means of photoacoustic and ultrasound

[0038] (1)将微型光声超声双模成像内窥探头(直径1. 4mm)插入离体兔腹主动脉管腔内; [0038] (1) within the dual-mode ultrasonic micro photoacoustic imaging snoop head (diameter 1. 4mm) inserted ex vivo rabbit abdominal aorta lumen;

[0039] (2)光声激发:采用Nd: YAG泵浦的光纤激光器(Brilliant B, Bigsky),输出激光波长为1064nm,脉宽为8ns,重复频率是20HZ ;将上述激发器产生的脉冲激光(波长范围为IOOOnm)通过入射光纤耦合,经镀膜锥面高反射镜侧向均勻的入射到血管的管壁上,激发血 [0039] (2) Light acoustic excitation: the use of Nd: YAG laser pumped fiber (Brilliant B, Bigsky), the output laser wavelength of 1064nm, a pulse width 8ns, repetition frequency 20HZ; the above-described pulsed laser excitation generated (wavelength range IOOOnm) through the incident optical fiber coupled, by coating the high reflection mirror side tapered surface uniformly incident on the blood vessel wall, blood excitation

管壁产生光声信号; Wall photoacoustic signal;

[0040] (3)光声采集:中空圆环阵列超声探测器(由64个振元组成,外径为1. 2mm,内径0. 3mm,主频为20MHz)接收到光声信号后,经超声信号激发与采集组件通过同轴数据传输线进行数据采集,再将数据传输并储存到带有采集控制软件和图像重建软件的计算机中; [0040] (3) collecting the photoacoustic: a hollow annular array ultrasonic probe (a transducer element 64 composed of an outer diameter of 1. 2mm, an inner diameter of 0. 3mm, clocked at 20MHz), after receiving the photoacoustic signal, the ultrasonic signal excitation and acquisition component data acquisition through a coaxial transmission line data, then the data transmitted and stored to a computer with control software acquisition and image reconstruction software;

[0041] (4)超声激发和采集:光声信号采集完毕后,超声激发与采集组件先对中空圆环阵列超声探测器中的一个超声振元进行激发,中空圆环阵列超声探测器接收超声回波信号后,经超声激发与采集组件通过同轴数据传输线进行数据采集,然后超声激发与采集组件依次对中空圆环阵列超声探测器中的下一个超声振元进行激发和数据采集;最后将数据传输并储存到带有采集控制软件和图像重建软件的计算机中; [0041] (4) an ultrasonic excitation and acquisition: the photoacoustic signal acquisition is completed, the ultrasonic excitation and acquisition component of a first hollow annular array ultrasonic probe in the ultrasonic vibrator element is excited, a hollow annular array ultrasonic probe receives ultrasound after the echo signals excited by ultrasound data acquisition and acquisition component through a coaxial transmission line data, and then sequentially excite the ultrasound transducer element at a hollow annular array ultrasonic probe in the ultrasonic excitation and data acquisition and acquisition component; finally and data transmission to a computer with stored control software and acquisition of image reconstruction software;

[0042] (5)数据处理:对采集的数据进行处理,通过MATLAB程序利用滤波反投影算法进行图像重建,得到血管的光声和超声图像,即如图4(a)所示的图像;图4(b)给出了样品图4(a)的光声横向层析图像,图4(c)给出了样品图4(a)的超声横向层析图像,从实验结果可以看出本发明的方法和装置能够得到的光声和超声横向层析图像。 [0042] (5) Data processing: data acquisition process is performed using a filtered back projection image reconstruction algorithm MATLAB program to obtain photoacoustic and ultrasound images of blood vessels, i.e., the image shown in FIG. 4 (a) in FIG.; FIG. 4 (b) shows the sample of FIG photoacoustic 4 (a) of the lateral tomographic image, FIG. 4 (c) shows the transverse ultrasonic tomographic image of the sample of FIG. 4 (a) can be seen from the experimental results of the present invention method and lateral photoacoustic and ultrasound tomographic images can be obtained of the apparatus.

[0043] 实施例3 : [0043] Example 3:

[0044] 应用实施例1所述装置实现血管管腔横截面的光声和超声内窥成像 The endoscopic imaging [0044] Application Example 1 the cross-section of the lumen of blood vessels means of photoacoustic and ultrasound

[0045] (1)将微型光声超声双模成像内窥探头(直径1. 3mm)插入离体兔腹主动脉管腔内; [0045] (1) within the dual-mode ultrasonic micro photoacoustic imaging snoop head (diameter of 1. 3mm) is inserted into the abdominal ex vivo rabbit aorta lumen;

[0046] (2)光声激发、光声采集与超声激发和采集:采用Nd:YAG泵浦的光纤激光器(Brilliant B, Bigsky),输出激光波长为1064nm,脉宽为8ns,重复频率是20HZ ;将上述激发器产生的脉冲激光(波长范围为IOOOnm)通过入射光纤耦合,经镀膜锥面高反射镜侧向均勻的入射到血管的管壁上,激发血管壁产生光声信号;中空圆环阵列超声探测器(由64 个振元组成,外径为1. Omm,内径0. 4mm,主频为40MHz)接收到光声信号后,经超声信号激发与采集组件通过同轴数据传输线进行数据采集,再将数据传输并储存到带有采集控制软件和图像重建软件的计算机中; [0046] (2) acoustic excitation light, the excitation light and ultrasonic sound acquisition and acquisition: The Nd: YAG laser pumped fiber (Brilliant B, Bigsky), the output laser wavelength of 1064 nm, 8ns pulse width, repetition frequency 20HZ ; above the upper laser excitation pulse generated (wavelength range IOOOnm) through the incident optical fiber coupler, the tapered surface coating uniformly high reflection mirror is incident side wall of the vessel, the vessel wall photoacoustic excitation signal; hollow ring ultrasound probe array (a transducer element 64 composed of an outer diameter of 1. Omm, an inner diameter of 0. 4mm, clocked at 40MHz) after receiving the photoacoustic signal, a data line via the data transmission through a coaxial ultrasonic signal excitation and acquisition component collect, store and then transfer the data to a computer with control software acquisition and image reconstruction software;

[0047] 同时,超声激发与采集组件对中空圆环阵列超声探测器中的一个超声振元进行激发,中空圆环阵列超声探测器接收超声回波信号后,经超声激发与采集组件通过同轴数据传输线进行数据采集,然后超声激发与采集组件依次对中空圆环阵列超声探测器中的下一个超声振元进行激发和数据采集;最后将数据传输并储存到带有采集控制软件和图像重建软件的计算机中;中空圆环阵列超声探测器同时接收 [0047] Meanwhile, an ultrasonic excitation and acquisition component of a hollow annular array ultrasonic probe in the ultrasonic vibrator element is excited, the hollow annular array ultrasonic probe receives ultrasound echo signals by ultrasonic excitation and acquisition component through a coaxial data transmission lines for data acquisition, the ultrasonic excitation and acquisition component and then sequentially hollow annular array ultrasonic probe in the ultrasonic transducer element for a next excitation and data acquisition; and finally transmits the data stored in the control software and acquisition with the image reconstruction software computer; hollow annular array while receiving the ultrasound probe

[0048] (3)数据处理:根据中空圆环阵列超声探测器接收超声回波和光声信号的接收时间差异,对采集的数据进行处理,通过MATLAB程序利用滤波反投影算法进行图像重建,实现光声超声的同时成像。 [0048] (3) Data processing: receiving ultrasound echo reception time and the difference of the photoacoustic signal, processing the collected data in accordance with a hollow annular array ultrasonic probe, image reconstruction is performed by using a filtered backprojection algorithm MATLAB program to achieve light acoustic imaging ultrasound simultaneously.

[0049] 上述实施例为本发明较佳的实施方式,但本发明的实施方式并不受上述实施例的限制,其他的任何未背离本发明的精神实质与原理下所作的改变、修饰、替代、组合、简化, 均应为等效的置换方式,都包含在本发明的保护范围之内。 [0049] The preferred embodiment of the present invention embodiment, but the embodiment of the present invention is not limited to the above embodiments, changes made to any other without departing from the spirit and principle of the present invention, modifications, substitutions , combined, simplified, should be equivalent replacement method, it is included within the scope of the present invention.

Claims (8)

1. 一种血管内光声超声双模成像内窥镜装置,其特征在于:该装置包括光声激发光源发生器、微型光声超声双模成像内窥探头、超声信号激发与采集组件和计算机;所述光声激发光源发生器、微型光声超声双模成像内窥探头、超声信号激发与采集组件和计算机依次电气相连;所述微型光声超声双模成像内窥探头由入射光纤、中空圆环阵列超声探测器、镀膜锥面高反射镜、管壳和医用级聚氯乙烯管组成;所述入射光纤与光声激发光源发生器相连,并穿过中空圆环阵列超声探测器;所述中空圆环阵列超声探测器通过同轴数据传输线与超声信号激发与采集组件相连;所述医用级聚氯乙烯管套在入射光纤、中空圆环阵列超声探测器、镀膜锥面高反射镜和管壳的外面;所述管壳将镀膜锥面高反射镜和入射光纤相连接,镀膜锥面高反射镜位于管壳内,而管壳固 An intravascular ultrasound dual mode photoacoustic imaging endoscope apparatus, wherein: the apparatus includes a light acoustic excitation light generator, the first snoop miniature dual-mode ultrasonic photoacoustic imaging, ultrasonic excitation and signal acquisition components and computer ; photoacoustic excitation light generator, the dual-mode ultrasonic micro photoacoustic imaging head snoop ultrasound signal excitation and acquisition component is electrically connected to the computer and sequentially; snoop head within said miniature dual-mode ultrasonic photoacoustic imaging by the incident optical fiber, hollow an annular array ultrasonic probe, the tapered surface high reflection mirror coating, shell and tube, and a medical grade polyvinyl chloride tubes; the acoustic excitation input optical fiber connected to the light source generator, and through the hollow annular array ultrasonic probe; the said hollow annular array coaxial with the ultrasound probe connected through the data transmission line and the ultrasonic signal acquisition component excitation; the medical grade PVC tube over the input fiber, hollow annular array ultrasonic probe, a high reflection mirror coating and the tapered surface the outer envelope; tapered surface of said envelope coating the high reflection mirror and incident optical fiber is connected to the tapered surface coating the high reflection mirror is located within the envelope, the envelope and the solid 在入射光纤的末端,镀膜锥面高反射镜的锥面正对着入射光纤;所述光声超声双模成像内窥镜的直径为1. 3mm〜1. 4mm。 At the end of the input fiber, the high reflection mirror coating tapered surface tapered surface facing the incident optical fiber; diameter of the dual-mode ultrasonic photoacoustic imaging endoscope is 1. 3mm~1 4mm..
2.根据权利要求1所述的一种血管内光声超声双模成像内窥镜装置,其特征在于:所述血管内光声超声双模成像内窥镜装置应用于光声和超声双模同时成像或单模切换成像。 2. According to an intravascular ultrasonic photoacoustic dual mode imaging endoscope apparatus as claimed in claim 1, wherein: said intravascular ultrasound and photoacoustic applied to dual-mode dual-mode ultrasonic photoacoustic imaging endoscope apparatus while the imaging or single mode switching image.
3.根据权利要求1所述的一种血管内光声超声双模成像内窥镜装置,其特征在于:所述光声激发光源发生器为短脉冲激光器,光声激发光源发生器产生的激光由单模光纤接合输出,所述光纤数值孔径为0. 22,所述激光的波长为400〜2500nm,脉宽范围为5ns〜 50ns ο 3. According to an intravascular ultrasonic photoacoustic dual mode imaging endoscope apparatus as claimed in claim 1, wherein: said acoustic excitation light source is a short-pulse laser generator, a laser light source the photoacoustic excitation generator output from the single mode fiber splice, the numerical aperture of the fiber is 0.22, the wavelength of the laser 400~2500nm, pulse width range 5ns~ 50ns ο
4.根据权利要求1所述的一种血管内光声超声双模成像内窥镜装置,其特征在于:所述光声激发光源发生器产生输出的激光通过入射光纤后,经镀膜锥面高反射镜向外反射成圆环形激发光,与中空圆环阵列超声探测器接收方向匹配,实现360度圆周的光声信号同轴激发和接收模式。 4. A member according to claim intravascular ultrasound dual mode photoacoustic imaging endoscope apparatus according to claim 1, wherein: said acoustic excitation light output from the laser light source generator through the input optical fiber, the tapered surface coating high mirror reflecting the excitation light outwardly in circular, matching the array direction of the hollow annular receiving the ultrasound probe, the photoacoustic signal to achieve 360 ​​degree circle coaxial excitation and reception mode.
5.根据权利要求4所述的一种血管内光声超声双模成像内窥镜装置,其特征在于:所述激光被镀膜锥面高反射镜反射后在中空圆环阵列超声探测器的法线方向上形成圆环形状光斑。 4 according to an intravascular ultrasonic photoacoustic the dual mode imaging endoscope apparatus as claimed in claim, wherein: said laser light is a hollow annular array method of the ultrasound probe after coating the high reflection mirror tapered surface forming an annular shape of the spot on the line direction.
6.根据权利要求1所述的一种血管内光声超声双模成像内窥镜装置,其特征在于:所述中空圆环超声探测器含有64阵元,内径为0.2〜0. 4mm,外径为1. 0〜1.2mm,主频为20MHz 〜40MHz。 6. An intravascular ultrasound claim 1 photoacoustic dual mode imaging endoscope apparatus as claimed in claim, characterized in that: said ultrasonic probe comprising a hollow cylindrical ring 64 element, an inner diameter of 0.2~0 4mm, outer. diameter of 1. 0~1.2mm, clocked at 20MHz ~40MHz.
7.根据权利要求1所述的一种血管内光声超声双模成像内窥镜装置,其特征在于:所述医用级聚氯乙烯管的末端为封闭的圆滑结构。 7. An intravascular ultrasound claim 1 photoacoustic dual mode imaging endoscope apparatus as claimed in claim, characterized in that: the end of the medical grade PVC tube is closed smooth structure.
8.根据权利要求1所述的一种血管内光声超声双模成像内窥镜装置,其特征在于:所述计算机中带有采集控制软件和图像重建软件。 An intravascular according to claim 1 photoacoustic dual mode ultrasound imaging apparatus as claimed in claim endoscope, wherein: the acquisition control computer with software and image reconstruction software.
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