CN107411708A - A kind of optical coherence tomography and photoacoustic imaging bimodal endoscope - Google Patents
A kind of optical coherence tomography and photoacoustic imaging bimodal endoscope Download PDFInfo
- Publication number
- CN107411708A CN107411708A CN201710364571.7A CN201710364571A CN107411708A CN 107411708 A CN107411708 A CN 107411708A CN 201710364571 A CN201710364571 A CN 201710364571A CN 107411708 A CN107411708 A CN 107411708A
- Authority
- CN
- China
- Prior art keywords
- coherence tomography
- optical coherence
- light source
- endoscope
- bimodal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00172—Optical arrangements with means for scanning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0661—Endoscope light sources
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Optics & Photonics (AREA)
- Acoustics & Sound (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Abstract
The present invention provides a kind of optical coherence tomography and photoacoustic imaging bimodal endoscope, including light source, cavity, the optical coherence tomography unit and photoacoustic imaging unit for being respectively arranged inside cavity, the optical coherence tomography unit includes single-mode fiber, gradient-index lens, reflecting prism and image scanning module；Optical coherence tomography and photoacoustic imaging bimodal endoscope in invention, it is combined by optical coherence tomography harmony photoimaging, bimodal based endoscopic imaging can be carried out, realize the less bimodal endoscope of size and realize and carried out while optical coherence tomography scans with photoacoustic imaging, particularly suitable for requiring that size higher occasion is imaged, such as in being imaged to the less blood vessel endoscope of diameter, present invention incorporates the big penetration depth of the high-resolution harmony photoimaging of optical coherence tomography, high field range and high-definition picture can be obtained simultaneously, good application prospect is provided for medical diagnosis development.
Description
Technical field
The present invention relates to optical field, more particularly to a kind of optical coherence tomography and photoacoustic imaging bimodal endoscope.
Background technology
Optical coherence tomography (Optical Coherence Tomography, OCT) grows up in the late two decades
The technology of high-resolution end face imaging can be carried out to mechanics of biological tissue.Compared with conventional imaging technique, optical coherence tomography
With advantage following prominent：Using near-infrared light source, to human zero damage；Make its resolution ratio very high using low coherence interference principle
(up to 10 microns or smaller)；Using fibre system, cost is relatively low and portable devices.Due to these advantages, optical coherence tomography
Very big development is being obtained in the late two decades, has been clinically the detection field of ophthalmology such as glaucoma, fundus oculi disease at present
Important tool.In addition to eyes, optical coherence tomography can be also imaged to the various tissues of human body, such as skin, tooth
Tooth etc..In order to be imaged to the organ of inside of human body, there is various coherence tomography endoscopics of optics 7 probe, can be with
Internal detection is stretched into, greatly expands application.For example, stretching into intravascular this probe, vascular cross-section can be carried out
Imaging, can be with to study the process and mechanism that vascular fatty and angiemphraxis are formed, the especially imaging to easily rupturable patch
Diagnose early atherosclerosis.By the development of nearly more than ten years, endoscopic optical coherent chromatography probe is in blood vessel, respiratory tract
Good application prospect is appeared with alimentary canal etc..
But optical image technology generally has the contradiction of field range and lateral resolution, can not generally realize simultaneously
Very wide field range and the lateral resolution of very little, optical coherence tomography are no exception.Pry head in traditional optics, including
Probe based on fibre bundle and based on camera, usual field range can reach several centimetres, but its lateral resolution only has
Tens microns.And in optical coherence tomography endoscopic probe, horizontal and vertical resolution ratio can reach about 10 microns, but it is regarded
Field is generally in the range of several millimeter magnitudes.In many applications, it is necessary to obtain big field range and high-resolution simultaneously, and existing skill
Art can not realize this point.On the other hand, because biological tissue scatters to the height of near infrared light, effective spy of optical coherence tomography
Depth measurement degree is also limited, is usually 1-2 millimeters for epidermal tissue.Which limits to stretch on a large scale tissue into
Picture.Therefore, need a kind of new technological means badly, the less bimodal endoscope of size can be realized and realize optical coherence tomography
Carried out while scanning with photoacoustic imaging, so as to for requiring higher occasion to size.
The content of the invention
In view of the above the shortcomings that prior art, the present invention provides a kind of optical coherence tomography and photoacoustic imaging bimodal
Endoscope, to solve above-mentioned technical problem.
Optical coherence tomography provided by the invention and photoacoustic imaging bimodal endoscope, including light source, cavity, set respectively
In the optical coherence tomography unit and photoacoustic imaging unit of inside cavity, the optical coherence tomography unit includes double clad light
Fibre, gradient-index lens, reflecting prism and image scanning module, the light source include for optical coherent chromatographic imaging
One light source and the secondary light source for acousto-optic imaging, first light source couples to single-mode fiber, pass through the image scanning mould
Block is imaged, and the secondary light source produces focus on light beam by the gradient-index lens, and the focus on light beam is by reflection rib
Mirror is reflexed on sample surfaces, and the photoacoustic imaging unit receives the sample and absorbs caused optoacoustic letter after pulse laser
Number, complete bimodal based endoscopic imaging.
Further, first light source is the infrared light supply for optical coherent chromatographic imaging, and the secondary light source is use
In the pulse laser of photoacoustic imaging, first light source carries out single mode transport by the internal layer of the doubly clad optical fiber.
Further, in addition to the ultrasonic detector that is arranged in cavity, the ultrasonic transducer are connected with doubly clad optical fiber,
First light source passes through the ultrasonic detector by the doubly clad optical fiber.
Further, the photoacoustic imaging unit includes optical resolution formula unit or acoustics resolution ratio formula unit, the
Two light source couples to doubly clad optical fiber is transmitted, and focus on light beam, the focusing light are produced by the gradient-index lens
Beam is reflexed on sample surfaces by reflecting prism, and the optical resolution formula unit receives the sample absorption pulse and swashed
Caused photoacoustic signal after light.
Further, the secondary light source carries out multimode transmissions coupled to the doubly clad optical fiber, is transmitted by multimode fibre
Pulse laser, focus on light beam is produced by the gradient-index lens, the focus on light beam reflexes to by reflecting prism
On sample surfaces, the acoustics resolution ratio formula unit receives the sample and absorbs caused photoacoustic signal after pulse laser.
Further, the image scanning module includes scanning mirror, micro machine and magnet, and the scanning mirror is fixed on magnet,
The magnet is rotated under the magnetically-actuated of micro machine.
Further, the inside cavity is filled with the liquid for being used for propagating acoustical signal and filled for the isolation of fluid partitioning
Put, the ultrasonic detector is mutually isolated by the isolating device with liquid respectively with the micro machine, and the scanning mirror is set
It is placed in liquid internal.
Further, the ultrasonic detector is hollow piezoelectric type ultrasonic transducer.
Beneficial effects of the present invention：Optical coherence tomography and photoacoustic imaging bimodal endoscope in the present invention, pass through light
Learn coherent tomographic harmony photoimaging to be combined, bimodal based endoscopic imaging can be carried out, realize the less bimodal endoscope of size
And realize and carried out while optical coherence tomography scans with photoacoustic imaging, particularly suitable for size is required higher occasion into
Picture, such as be imaged to the less blood vessel endoscope of diameter, present invention incorporates the high-resolution of optical coherence tomography and acousto-optic into
The big penetration depth of picture, high field range and high-definition picture can be obtained simultaneously, provided for medical diagnosis development good
Application prospect.
Brief description of the drawings
Fig. 1 is the structural representation of the present invention.
Fig. 2 is the method flow schematic diagram of the present invention.
Fig. 3 is the system structure diagram of the present invention.
Description of reference numerals：
Micro machine -1, magnet -2, scanning mirror -3, isolating device -4, liquid -5, acoustic lens -6, grin lenses -6, ultrasound are visited
Survey device -8, doubly clad optical fiber -9, signal wire -10, hyaline membrane -11, the first light source -21, secondary light source -22, dichroic filter -
23, lens -24, core -25, interior parcel -26, outer wrapping -27, signal wire -31, conducting resinl -32, ground wire -33, insulating cement -34 are double
Gold-plated lithium niobate -35 of layer, matching layer -36, acoustic lens -37.
Embodiment
Illustrate embodiments of the present invention below by way of specific instantiation, those skilled in the art can be by this specification
Disclosed content understands other advantages and effect of the present invention easily.The present invention can also pass through specific realities different in addition
The mode of applying is embodied or practiced, the various details in this specification can also be based on different viewpoints with application, without departing from
Various modifications or alterations are carried out under the spirit of the present invention.It should be noted that in the case where not conflicting, following examples and implementation
Feature in example can be mutually combined.
It should be noted that the diagram provided in following examples only illustrates the basic structure of the present invention in a schematic way
Think, only show the component relevant with the present invention in schema then rather than according to component count, shape and the size during actual implement
Draw, kenel, quantity and the ratio of each component can be a kind of random change during its actual implementation, and its assembly layout kenel
It is likely more complexity.
As shown in Figure 1, 2, the optical coherence tomography in the present embodiment and photoacoustic imaging bimodal endoscope, including light source,
Cavity, the optical coherence tomography unit and photoacoustic imaging unit for being respectively arranged inside cavity, the optical coherence tomography unit
Include including doubly clad optical fiber, gradient-index lens 7 (grin lenses), reflecting prism and image scanning module, the light source
Secondary light source 22 for the first light source 21 of optical coherent chromatographic imaging and for acousto-optic imaging, first light source 21 couple
To single-mode fiber, it is imaged by the image scanning module, the secondary light source 22 produces by the gradient-index lens
Focus on light beam, the focus on light beam are reflexed on sample surfaces by reflecting prism, described in the photoacoustic imaging unit reception
Sample absorbs caused photoacoustic signal after pulse laser, completes bimodal based endoscopic imaging, the present embodiment, can by doubly clad optical fiber
To ensure that optical coherent chromatographic imaging and photoacoustic imaging both imaging patterns realization are imaged with position, height can be obtained simultaneously and regarded
Field scope and high-definition picture, and the size popped one's head in is smaller, is suitable for requiring size higher occasion is imaged.
In the present embodiment, among probe, optical coherence tomography unit includes double optical coherent chromatographic imaging light path
Cladded-fiber, gradient-index lens 7 and reflecting prism, its longitudinal frame is determined by the spectrum width of near-infrared light source, and it is horizontal
Determine that optical coherence tomography unit is direct by optical fiber by the parameter of gradient-index lens and probe operating distance to resolution ratio
The signal that sample reflects is collected, is then detected by Optical coherence tomography end, completes optical coherent chromatographic imaging.
In the present embodiment, the first light source 21 is the infrared light supply used in optical coherence tomography, and secondary light source 22 is optoacoustic
Imaging pulse laser used, the first light source 21 carry out single mode transport by the doubly clad optical fiber.In input, optical coherence
The light of chromatography is coupled to the internal layer of doubly clad optical fiber by dichroic filter 23, and the pulsed light of photoacoustic imaging is then set depending on difference
Meter is coupled to the single-mode fiber of doubly clad optical fiber internal layer or the multimode fibre of outer layer.As shown in Figure 2.In addition, single-mode fiber is defeated
Entering end will be connected with Optical coherence tomography.Gradient-index lens will be placed behind optical fiber and produce focus on light beam, Ran Houjing
Speculum is crossed to reflex on sample surfaces.
In the present embodiment, including the ultrasonic detector 8 that is arranged in cavity, the ultrasonic detector 8 and double clad light
Fibre connection, the first light source 21 pass through the ultrasonic transducer by the single-mode fiber, as shown in figure 3, super in the present embodiment
Detector of sound 8 uses a hollow piezoelectric type ultrasonic transducer, the hollow piezoelectric type ultrasonic transducer in the present embodiment
Structure is as shown in figure 3, including signal wire 31, conducting resinl 32, ground wire 33, insulating cement 34, double-deck gold-plated lithium niobate 35, matching layer 36
With acoustic lens 37, it is hollow structure that it is internal, and hollow space is connected with doubly clad optical fiber 9.
In the present embodiment, photoacoustic imaging unit includes optical resolution formula unit or acoustics resolution ratio formula unit the
Two light sources 22 carry out single mode transmission coupled to doubly clad optical fiber, and focus on light beam is produced by the gradient-index lens, described
Focus on light beam is reflexed on sample surfaces by reflecting prism, and the optical resolution formula unit receives the sample and absorbed
Caused photoacoustic signal after pulse laser；Secondary light source 22 carries out multimode transmissions coupled to the doubly clad optical fiber, passes through multimode
Optical fiber transfer pulse laser, focus on light beam is produced by the gradient-index lens 7, the focus on light beam passes through reflecting prism
Reflex on sample surfaces, the acoustics resolution ratio formula unit receives the sample and absorbs caused optoacoustic after pulse laser
Signal.Optical resolution formula can obtain high-definition picture in shallow-layer, and acoustics resolution ratio formula can obtain up to several centimeters one-tenth
As depth and appropriate resolution ratio.In optical resolution formula, pulse laser transmits via single-mode fiber, and is reflected by gradual change type
Rate lens focus is beaten on sample, and optical coherence tomography light source also can pass through the transmission of same single-mode fiber.Sample absorbs pulse
Caused photoacoustic signal will be received by ultrasonic detector after laser.By lateral resolution is determined by focal beam spot size,
Therefore ultrasonic probe can be non-focusing formula or weak focus formula.In acoustics resolution mode, due to laser out-focus, it need to use more
Mode fiber carries enough laser energies.Additionally, due to laser out-focus, therefore ultrasonic detector 8 is necessary for focusing, with
Lateral resolution needed for imaging is just provided.Both modes can be realized inside same system, in the present embodiment
Doubly clad optical fiber structure as shown in Fig. 2 including core 25, interior parcel 26 and outer wrapping 27,.
In the present embodiment, image scanning module includes scanning mirror 3, micro machine 1 and magnet 2, and the scanning mirror 3 is fixed on
Magnet 2, the magnet 2 are rotated under the magnetically-actuated of micro machine 1, the small magnet 2 that the scanning of imaging is driven by micro machine 1
By magnetically-actuated, another small magnet is realized, scanning mirror 3 is pasted onto on small magnet and is driven to rotate.Cavity in the present embodiment
Inside, which is filled with, is used for the liquid 5 for propagating acoustical signal and the isolating device 4 for fluid partitioning, and the present embodiment is filled using isolation
Put 4 to be isolated, its specific structure is as shown in figure 1, ultrasonic detector 8 isolates dress by described respectively with the micro machine 1
Put 4 to be mutually isolated with liquid 5, the scanning mirror 3 is arranged at liquid internal, and the liquid 5 in the present embodiment is water, ultrasonic detector
8 parts need to wash by water to propagate acoustical signal, and this part needs to keep apart with micro machine 1 and probe other parts.
The above-described embodiments merely illustrate the principles and effects of the present invention, not for the limitation present invention.It is any ripe
Know the personage of this technology all can carry out modifications and changes under the spirit and scope without prejudice to the present invention to above-described embodiment.Cause
This, those of ordinary skill in the art is complete without departing from disclosed spirit and institute under technological thought such as
Into all equivalent modifications or change, should by the present invention claim be covered.
Claims (8)
1. a kind of optical coherence tomography and photoacoustic imaging bimodal endoscope, it is characterised in that：Including light source, cavity, set respectively
The optical coherence tomography unit and photoacoustic imaging unit of inside cavity are placed in, the optical coherence tomography unit includes double clad light
Fibre, gradient-index lens, reflecting prism and image scanning module, the light source include for optical coherent chromatographic imaging
One light source and the secondary light source for acousto-optic imaging, first light source couples to single-mode fiber, pass through the image scanning mould
Block is imaged, and the secondary light source produces focus on light beam by the gradient-index lens, and the focus on light beam is by reflection rib
Mirror is reflexed on sample surfaces, and the photoacoustic imaging unit receives the sample and absorbs caused optoacoustic letter after pulse laser
Number, complete bimodal based endoscopic imaging.
2. optical coherence tomography according to claim 1 and photoacoustic imaging bimodal endoscope, it is characterised in that：Described
One light source is the infrared light supply for optical coherent chromatographic imaging, and the secondary light source is the pulse laser for photoacoustic imaging,
First light source carries out single mode transport by the internal layer of the doubly clad optical fiber.
3. optical coherence tomography according to claim 2 and photoacoustic imaging bimodal endoscope, it is characterised in that：Also include
The ultrasonic detector being arranged in cavity, the ultrasonic transducer are connected with doubly clad optical fiber, and the first light source passes through the double-contracting
Layer optical fiber passes through the ultrasonic detector.
4. optical coherence tomography according to claim 2 and photoacoustic imaging bimodal endoscope, it is characterised in that：The light
Acoustic imaging unit includes optical resolution formula unit or acoustics resolution ratio formula unit, secondary light source are coupled to doubly clad optical fiber
Transmitted, produce focus on light beam by the gradient-index lens, the focus on light beam reflexes to by reflecting prism
On sample surfaces, the optical resolution formula unit receives the sample and absorbs caused photoacoustic signal after pulse laser.
5. optical coherence tomography according to claim 4 and photoacoustic imaging bimodal endoscope, it is characterised in that：Described
Two light source couples to the doubly clad optical fiber carries out multimode transmissions, by multimode fibre transfer pulse laser, by the gradient
Index lens produce focus on light beam, and the focus on light beam is reflexed on sample surfaces by reflecting prism, the acoustics point
Resolution formula unit receives the sample and absorbs caused photoacoustic signal after pulse laser.
6. optical coherence tomography according to claim 3 and photoacoustic imaging bimodal endoscope, it is characterised in that：It is described into
Picture scan module includes scanning mirror, micro machine and magnet, and the scanning mirror is fixed on magnet, magnetic force of the magnet in micro machine
Rotated under driving.
7. optical coherence tomography according to claim 6 and photoacoustic imaging bimodal endoscope, it is characterised in that：The chamber
Internal portion, which is filled with, is used for the liquid for propagating acoustical signal and the isolating device for fluid partitioning, the ultrasonic detector and institute
State micro machine to be mutually isolated with liquid by the isolating device respectively, the scanning mirror is arranged at liquid internal.
8. optical coherence tomography according to claim 3 and photoacoustic imaging bimodal endoscope, it is characterised in that：It is described super
Detector of sound is hollow piezoelectric type ultrasonic transducer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710364571.7A CN107411708A (en) | 2017-05-22 | 2017-05-22 | A kind of optical coherence tomography and photoacoustic imaging bimodal endoscope |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710364571.7A CN107411708A (en) | 2017-05-22 | 2017-05-22 | A kind of optical coherence tomography and photoacoustic imaging bimodal endoscope |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107411708A true CN107411708A (en) | 2017-12-01 |
Family
ID=60427998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710364571.7A Pending CN107411708A (en) | 2017-05-22 | 2017-05-22 | A kind of optical coherence tomography and photoacoustic imaging bimodal endoscope |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107411708A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108362646A (en) * | 2018-02-07 | 2018-08-03 | 上海交通大学 | A kind of system of miniature opto-acoustic microscopic imaging head, production method and its composition |
| CN108709623A (en) * | 2018-04-26 | 2018-10-26 | 上海交通大学 | The production method of optoacoustic lens focuses ultrasonic device and focuses ultrasonic measurement system |
| CN109567758A (en) * | 2018-12-29 | 2019-04-05 | 中国科学院深圳先进技术研究院 | Across the scale photoacoustic imaging system of one kind |
| CN110398461A (en) * | 2019-07-11 | 2019-11-01 | 上海交通大学 | A kind of three-D imaging method for realizing dendrite in lithium metal battery using photoacoustic imaging |
| CN110584570A (en) * | 2019-10-12 | 2019-12-20 | 深圳大学 | Endoscopic photoacoustic imaging system for all-optical detection |
| CN111134591A (en) * | 2019-12-27 | 2020-05-12 | 华南师范大学 | Photoacoustic microscopic imaging pen and imaging method |
| CN113520272A (en) * | 2021-06-29 | 2021-10-22 | 上海应用技术大学 | Endoscopic catheter-multi-mode optical imaging coupling detection system |
| CN114931358A (en) * | 2022-04-06 | 2022-08-23 | 上海健康医学院 | Large depth of field micrometer resolution optical coherence tomography endoscopic probe |
| CN115568820A (en) * | 2022-09-05 | 2023-01-06 | 暨南大学 | All-fiber photoacoustic endoscopic imaging device and system based on far-end scanning |
Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103048271A (en) * | 2012-12-21 | 2013-04-17 | 江西科技师范大学 | Portable type bi-modal imaging method employing combined photoacoustic imaging and optical coherence tomography and system of method |
| CN103048294A (en) * | 2012-12-21 | 2013-04-17 | 江西科技师范大学 | Integrated multi-mode imaging method fusing ultrasonic imaging, photoacoustic imaging and optical coherence tomography and system employing same |
| CN103385758A (en) * | 2013-07-22 | 2013-11-13 | 深圳先进技术研究院 | Intravascular opto-acoustic and ultrasonic dual-mode imaging system and imaging method thereof |
| CN103462645A (en) * | 2012-06-07 | 2013-12-25 | 中国科学院深圳先进技术研究院 | Forward-looking optic-acoustic endoscope |
| CN103501707A (en) * | 2011-04-27 | 2014-01-08 | 富士胶片株式会社 | Photoacoustic measurement device, probe unit used in same, and endoscope |
| CN103690141A (en) * | 2013-12-26 | 2014-04-02 | 广州佰奥廷电子科技有限公司 | Internal rectal optical, optoacoustic and ultrasonic multimode imaging endoscope and imaging method thereof |
| CN104188625A (en) * | 2014-08-20 | 2014-12-10 | 上海交通大学 | Multimodal microscopic imaging system |
| US20150133775A1 (en) * | 2013-11-08 | 2015-05-14 | Samsung Electronics Co., Ltd. | Probe and medical imaging apparatus including the same |
| CN105030281A (en) * | 2015-08-26 | 2015-11-11 | 广州瑞达医疗器械有限公司 | Photoacoustic-ultrasonic dual-mode rectum endoscope |
| US20160045102A1 (en) * | 2014-08-12 | 2016-02-18 | Bing Yu | Multimodal endoscope apparatus |
| CN105769128A (en) * | 2016-05-06 | 2016-07-20 | 华南师范大学 | Integrated opto-acoustic, ultrasonic and opto-acoustic elastic endoscopic imaging device and method thereof |
| KR20160096268A (en) * | 2015-02-04 | 2016-08-16 | 포항공과대학교 산학협력단 | Optical imaging apparatus and system for multi-depth image |
| US20160374562A1 (en) * | 2013-03-15 | 2016-12-29 | LX Medical, Inc. | Tissue imaging and image guidance in luminal anatomic structures and body cavities |
| CN106361294A (en) * | 2016-11-15 | 2017-02-01 | 华南师范大学 | Device and method for endovascular optical coherence tomography - opto-acoustic - ultrasonic multimode imaging |
| CN206138103U (en) * | 2016-08-01 | 2017-05-03 | 苏州卓特医疗科技有限公司 | Miniature optoacoustic endoscope probe |
| KR101736113B1 (en) * | 2016-03-16 | 2017-05-17 | 한국광기술원 | Convergence catheter and imaging processing system for cardiovascular diagnosis |
-
2017
- 2017-05-22 CN CN201710364571.7A patent/CN107411708A/en active Pending
Patent Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103501707A (en) * | 2011-04-27 | 2014-01-08 | 富士胶片株式会社 | Photoacoustic measurement device, probe unit used in same, and endoscope |
| CN103462645A (en) * | 2012-06-07 | 2013-12-25 | 中国科学院深圳先进技术研究院 | Forward-looking optic-acoustic endoscope |
| CN103048294A (en) * | 2012-12-21 | 2013-04-17 | 江西科技师范大学 | Integrated multi-mode imaging method fusing ultrasonic imaging, photoacoustic imaging and optical coherence tomography and system employing same |
| CN103048271A (en) * | 2012-12-21 | 2013-04-17 | 江西科技师范大学 | Portable type bi-modal imaging method employing combined photoacoustic imaging and optical coherence tomography and system of method |
| US20160374562A1 (en) * | 2013-03-15 | 2016-12-29 | LX Medical, Inc. | Tissue imaging and image guidance in luminal anatomic structures and body cavities |
| CN103385758A (en) * | 2013-07-22 | 2013-11-13 | 深圳先进技术研究院 | Intravascular opto-acoustic and ultrasonic dual-mode imaging system and imaging method thereof |
| US20150133775A1 (en) * | 2013-11-08 | 2015-05-14 | Samsung Electronics Co., Ltd. | Probe and medical imaging apparatus including the same |
| CN103690141A (en) * | 2013-12-26 | 2014-04-02 | 广州佰奥廷电子科技有限公司 | Internal rectal optical, optoacoustic and ultrasonic multimode imaging endoscope and imaging method thereof |
| US20160045102A1 (en) * | 2014-08-12 | 2016-02-18 | Bing Yu | Multimodal endoscope apparatus |
| CN104188625A (en) * | 2014-08-20 | 2014-12-10 | 上海交通大学 | Multimodal microscopic imaging system |
| KR20160096268A (en) * | 2015-02-04 | 2016-08-16 | 포항공과대학교 산학협력단 | Optical imaging apparatus and system for multi-depth image |
| CN105030281A (en) * | 2015-08-26 | 2015-11-11 | 广州瑞达医疗器械有限公司 | Photoacoustic-ultrasonic dual-mode rectum endoscope |
| KR101736113B1 (en) * | 2016-03-16 | 2017-05-17 | 한국광기술원 | Convergence catheter and imaging processing system for cardiovascular diagnosis |
| CN105769128A (en) * | 2016-05-06 | 2016-07-20 | 华南师范大学 | Integrated opto-acoustic, ultrasonic and opto-acoustic elastic endoscopic imaging device and method thereof |
| CN206138103U (en) * | 2016-08-01 | 2017-05-03 | 苏州卓特医疗科技有限公司 | Miniature optoacoustic endoscope probe |
| CN106361294A (en) * | 2016-11-15 | 2017-02-01 | 华南师范大学 | Device and method for endovascular optical coherence tomography - opto-acoustic - ultrasonic multimode imaging |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108362646A (en) * | 2018-02-07 | 2018-08-03 | 上海交通大学 | A kind of system of miniature opto-acoustic microscopic imaging head, production method and its composition |
| CN108709623A (en) * | 2018-04-26 | 2018-10-26 | 上海交通大学 | The production method of optoacoustic lens focuses ultrasonic device and focuses ultrasonic measurement system |
| CN109567758A (en) * | 2018-12-29 | 2019-04-05 | 中国科学院深圳先进技术研究院 | Across the scale photoacoustic imaging system of one kind |
| CN110398461A (en) * | 2019-07-11 | 2019-11-01 | 上海交通大学 | A kind of three-D imaging method for realizing dendrite in lithium metal battery using photoacoustic imaging |
| CN110584570A (en) * | 2019-10-12 | 2019-12-20 | 深圳大学 | Endoscopic photoacoustic imaging system for all-optical detection |
| CN110584570B (en) * | 2019-10-12 | 2022-11-08 | 深圳大学 | All-optical detection endoscopic photoacoustic imaging system |
| CN111134591A (en) * | 2019-12-27 | 2020-05-12 | 华南师范大学 | Photoacoustic microscopic imaging pen and imaging method |
| CN113520272A (en) * | 2021-06-29 | 2021-10-22 | 上海应用技术大学 | Endoscopic catheter-multi-mode optical imaging coupling detection system |
| CN114931358A (en) * | 2022-04-06 | 2022-08-23 | 上海健康医学院 | Large depth of field micrometer resolution optical coherence tomography endoscopic probe |
| CN115568820A (en) * | 2022-09-05 | 2023-01-06 | 暨南大学 | All-fiber photoacoustic endoscopic imaging device and system based on far-end scanning |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107411708A (en) | A kind of optical coherence tomography and photoacoustic imaging bimodal endoscope | |
| Zhou et al. | Photoacoustic imaging with fiber optic technology: A review | |
| Chen et al. | Progress of clinical translation of handheld and semi-handheld photoacoustic imaging | |
| JP4494127B2 (en) | Tomographic image observation device, endoscope device, and probe used for them | |
| CN104188625B (en) | A kind of multi-modal micro imaging system | |
| CN104027068B (en) | A kind of real-time multimode state optoacoustic eyes imaging system and formation method thereof | |
| US8016419B2 (en) | Systems and methods for photoacoustic opthalmoscopy | |
| CN104825121B (en) | Endoscopic OCT (Optical Coherence Tomography) miniature probe, OCT imaging system and use method | |
| CN104684457B (en) | Use OCT light source and the two-dimentional confocal imaging of scanning optics | |
| US20160228097A1 (en) | Hybrid systems and methods for multi-modal acquisition of intravascular imaging data and counteracting the effects of signal absorption in blood | |
| CN105877711B (en) | A kind of skin disease multi-modality imaging detection system | |
| KR101736113B1 (en) | Convergence catheter and imaging processing system for cardiovascular diagnosis | |
| WO2017124912A1 (en) | Double-focusing ultrasonic probe and sparse array photo-acoustic tomography system | |
| US20180028117A1 (en) | Ultrasound probe | |
| CN103462645B (en) | Forward sight Photoacoustic endoscope | |
| WO2010048258A1 (en) | Reflection-mode photoacoustic tomography using a flexibly-supported cantilever beam | |
| CN104323762B (en) | A kind of nevus flammeus blood vessel quantification detection means based on opto-acoustic microscopic imaging | |
| JPH04135551A (en) | Optical three-dimensional image observing device | |
| CN105662476B (en) | Optoacoustic/ultrasonic probe is peeped in full view | |
| CN205758513U (en) | A kind of dermatosis multi-modality imaging detecting system | |
| CN108670177A (en) | A kind of Intraductal lesion imaging probe | |
| CN104825180A (en) | Tri-modal breast imaging system and imaging method thereof | |
| RU184084U1 (en) | The device of an endoscopic probe for optical coherence tomography | |
| CN110251099A (en) | A kind of multi-modality imaging equipment for combining optoacoustic and optical fiber type laser speckle | |
| CN101703415B (en) | Hard ultrasonic gallbladder endoscope system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171201 |