CN108670177A - A kind of Intraductal lesion imaging probe - Google Patents
A kind of Intraductal lesion imaging probe Download PDFInfo
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- CN108670177A CN108670177A CN201810524691.3A CN201810524691A CN108670177A CN 108670177 A CN108670177 A CN 108670177A CN 201810524691 A CN201810524691 A CN 201810524691A CN 108670177 A CN108670177 A CN 108670177A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/05—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00064—Constructional details of the endoscope body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00131—Accessories for endoscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0091—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for mammography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0097—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying acoustic waves and detecting light, i.e. acoustooptic measurements
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Abstract
The present invention provides a kind of Intraductal lesion imaging probe, pulse laser is coupled into one end of excitation fiber, pass through collimation focal element focusing illumination to reflecting element back reflection in the other end of excitation fiber, it is focused under organism inner surface through capsule, since acoustooptical effect generates ultrasonic signal, reflected ultrasonic signal is irradiated to reflecting element back reflection through capsule and focuses on optical resonance element, changes the resonant frequency of optical resonance element；Detection light is coupled into one end of reception optical fiber, and optical resonance element is coupled into the other end of reception optical fiber, and the detection light for changing resonant frequency is reflected from reception optical fiber, and three-dimensional imaging is carried out by optical detector and imaging unit.The invention enables device integration higher, miniaturizations, realize the sound and light signal acquisition of the full light of low cost, miniaturization, optical clear and high bandwidth, greatly improve the existing fiberoptic ductoscopy technology clinically used.
Description
Technical field
The invention belongs to endoscopic imaging technical fields, and in particular to a kind of Intraductal lesion imaging probe.
Background technology
Pathologic nipple discharge is one of common manifestation of breast lesion.Common disease factor have breast intraductal papilloma,
Mammary duct ectasia, breast cancer, plasmacellular mastitis etc..Before fiberoptic ductoscopy technological invention and application, including ultrasound, magnetic resonance
And the detection methods such as molybdenum target can not all obtain accurate diagnostic result.Fiberoptic ductoscopy is a kind of scope pickup-light source system, can
To line-of-sight observation the performance of lesion in latex dust, while the biopsy of lesion can be carried out, the Lavage for Treatment of drug can also be carried out.But
Existing fiberoptic ductoscopy has the following deficiencies：The first, the imaging depth of fiberoptic ductoscopy is limited.Fiberoptic ductoscopy into mirror depth by mirror body
The limitation of diameter, length and curvature cannot reach the tip latex dust less than mirror body diameter.Research shows that intracanalicular papilloma
Ductule and eventually last ductal epithelial cell and interstitial are often betided, and ductule and eventually last conduit often expand unobvious, to lead
Cause is failed to pinpoint a disease in diagnosis.The second, latex dust spectroscopy What You See Is What You Get can not carry out lesion and wherein surrounding tissue more slice scannings, need
Conduits at different levels are checked step by step, and can only obtain two dimensional image, are supplied to the diagnostic message of clinician limited.While because
To check that make a definite diagnosis efficiency low, as a kind of invasive inspection, pain is larger caused by patient.Third, fiberoptic ductoscopy resolution ratio have
Limit lacks the judgement to lesion tissue elasticity and functional status.
Acousto-optic endoscope as a kind of novel optical imagery that can be used for inside noninvasive hollow organ with ultrasound at
As be combined hybrid imaging technique, be concerned by people in the fields such as blood vessel and stomach lesion, it mainly has following
Advantage：The first, harmless.Acousto-optic imaging does not generate any ionising radiation, without using any biomarker, does not destroy yet
Or change any tissue property.The second, imaging depth is deep, contrast is strong and high resolution.Acousto-optic imaging utilizes the strong of ultrasonic wave
Through characteristic and tissue are anisotropic to the absorption difference of laser, realize the imaging of the high-resolution and high contrast of tissue deeper inside.
Third has function imaging ability.Acousto-optic, which is imaged, can also measure the absorption coefficient of tissue different piece, and with it is corresponding
Molecular structure or physiological status are associated, monitor the functional status of tissue, for example, content of hemoglobin in blood vessel, oxygen metabolism and
Tumour progression etc..
The basic principle of acousto-optic endoscopic imaging technology includes mainly three steps：The first, pulse laser passes through in probe
Optical element be irradiated to biological tissue；The second, biological tissue's body absorbs pulse laser fever, generates optoacoustic effect and outside spoke
Penetrate ultrasonic wave；Ultrasonic detector in third, probe receives ultrasonic wave, is converted into corresponding electric signal and is transmitted in computer,
Image is exported using image reconstruction algorithm.Therefore pop one's head in sensor and optical element be acousto-optic imaging core technology it
One.Probe in existing acousto-optic endoscopic imaging system is mostly using the sonac based on piezoelectric sensing.It is this
The usual volume of sensor is larger, and being placed in endoscope probe after miniaturization leads to sensitivity and detective bandwidth limited performance,
And it is not easy the array of integrated multi-sensor, therefore limits resolution ratio, signal-to-noise ratio and the speed of imaging so that Real-time High Resolution
This kind of imaging applications of rate are difficult to realize.In addition piezo ultrasound transducers is optically opaque, increases the optics member of endoscope
Part design difficulty.In order to solve this problem, the various acousto-optic imagings comprising more compact, higher resolution sonac are visited
Head is constantly proposed.How using the continuous resolution ratio for promoting acousto-optic imaging probe and to minimize and obtain higher-quality picture
The target that always everybody pursues.
The endoscope probe design for being currently based on acousto-optic imaging technique mainly has the following two kinds：
The first design is as shown in Figure 1, come from document " A miniature all-optical photoacoustic
imaging probe”Proc.of SPIE Vol.7899,78991F(2011).This acousto-optic endoscope imaging probe includes：
Casing 1-1, single mode optical fiber 1-2, sound and light signal detection sensor 1-3, capsule 1-4.One end of single mode optical fiber 1-2 is fixed on casing
It in 1-1, and is of coupled connections, can be rotated around fiber axis with excitation light source.The other end of single mode optical fiber 1-2 be polished to fiber axis at
The reflecting surface of 45 degree of angles is placed in capsule 1-4.Pass through multicoating work on the clad of the other end of single mode optical fiber 1-2
Skill is prepared in sound and light signal detection sensor 1-3, capsule 1-4 based on Fabry Perot thin polymer film principle filled with air.
Pop one's head in work when, optical excitation signal is coupled into from one end of single mode optical fiber 1-2, is occurred entirely on the reflecting surface of 45 degree of the other end
Reflection, the rear portion for penetrating sound and light signal detection sensor 1-3 focus on certain point in biological tissue, and another part is reflected back
To be again introduced into single mode optical fiber 1-2.The point in biological tissue absorbs the energy of exciting light, generates ultrasonic signal and is radiated sound
On optical signal detection sensor 1-3, change the intensity or position phase of reflected light signal by changing its film morphology, and transmit
Telegram in reply brain realizes that image is shown by image reconstruction algorithm.There are three disadvantages for this scheme：First, although the optical fiber on cylindrical surface
Side wall can play the role of exciting light the convergence along fiber axis vertical direction, but its excitation density or relatively low, therefore institute
The power consumption needed is larger.Second, the unspecial focal element of ultrasonic signal, therefore collection efficiency is low, loss of signal is big.The
Three, the microcavity of Fabry Perot type due to quality factor it is low, the detectivity of sound and light signal is relatively low, cause image point
Resolution is limited.
Second of design is as shown in Fig. 2, from document " a kind of intravascular imaging system and method ", Chinese patent
CN104545811B.This acousto-optic endoscope imaging probe includes：Multimode fibre 2-1, flexure spring coil 2-2, matching pipe 2-
3, focal element 2-4, reflecting element 2-5, ultrasonic transducer 2-6, support component 2-7 and protective case 2-8.Match pipe 2-3, convergence
Element 2-4, reflecting element 2-5, ultrasonic transducer 2-6 and support component 2-7 are arranged in protective case 2-8.Flexure spring line
One end of circle 2-2 is fixed on the inner wall of protective case 2-8, and the other end is connect with excitation light source.One end of multimode fibre 2-1 pass through
Be piped inside 2-3, and be fixed on one end of focal element 2-4, reflecting element 2-5 be fixed on the other end of focal element 2-4 with
Between ultrasonic transducer 2-6.Ultrasonic transducer 2-6 is set on support component 2-7.Pop one's head in work when, optical excitation signal is from more
One end of mode fiber 2-1 is coupled into, and is converged by focal element 2-4, then is reflected by reflecting element 2-5, focuses on biological group
Knit interior certain point.The point in biological tissue absorbs the energy of exciting light, generates ultrasonic signal and is received by ultrasonic transducer 2-6
And computer is sent back, realize that image is shown by image reconstruction algorithm.The shortcomings that this scheme is to use ultrasonic transducer, optics
It is opaque, cause optical design complicated, integrated level is low, and resolution ratio and signal-to-noise ratio are limited by piezoelectric material volume.
Invention content
The technical problem to be solved by the present invention is to：A kind of Intraductal lesion imaging probe is provided, optical design can be simplified,
So that device integration higher, miniaturization.
The technical solution taken by the invention to solve the above technical problem is：A kind of Intraductal lesion imaging probe, packet
Include optical fiber, collimation focal element, reflecting element and capsule, it is characterised in that：The optical fiber includes excitation fiber and reception light
Fibre, this probe further include the optical resonance element for changing resonant frequency under the ultrasonic wave of return；
The position of the excitation fiber, reception optical fiber, collimation focal element, reflecting element, capsule and optical resonance element
The relationship of setting meets following optical path：Pulse laser is coupled into one end of excitation fiber, logical in the other end of excitation fiber
Collimation focal element focusing illumination is crossed to reflecting element back reflection, is focused under organism inner surface through capsule, due to acousto-optic
Effect generates ultrasonic signal, and reflected ultrasonic signal is irradiated to reflecting element back reflection through capsule and focuses on optical resonance
Element changes the resonant frequency of optical resonance element；Detection light is coupled into one end of reception optical fiber, in the another of reception optical fiber
One end is coupled into optical resonance element, and the detection light for changing resonant frequency is reflected from reception optical fiber, by optical detector
Three-dimensional imaging is carried out with imaging unit.
By said program, the excitation fiber, reception optical fiber, collimation focal element, reflecting element and optical resonance member
Part is arranged in the capsule, and excitation fiber and reception optical fiber are located at the same side of reflecting element.
By said program, the excitation fiber, reception optical fiber, collimation focal element, reflecting element and optical resonance member
Part constitutes one can be around the entirety of the axial-rotation of the capsule.
By said program, the optical resonance element includes the Planar integration waveguide device for having elasto-optical effect, plane
Integrated waveguide device is made of grating coupler, connection waveguide and micro-ring resonant cavity；Planar integration waveguide device integral manufacturing exists
On the end face of reception optical fiber, and the grating coupler is aligned with the core of reception optical fiber.
By said program, the Planar integration waveguide device is polymer material, and imprints work using semiconductor nano
Skill is produced on the end face of reception optical fiber.
By said program, the both ends of the grating coupler are connected with waveguide head and the tail are connect, the micro-ring resonant cavity
It is equipped with certain gap with connecting between waveguide, and micro-ring resonant cavity position is arranged in the surface of grating coupler.
By said program, the reflecting element include 2 independent speculums, wherein the first speculum for reflect or
The laser exported from collimation focal element is converged, the second speculum is for reflecting or converging reflected ultrasonic signal.
By said program, there is first speculum optical reflection face, second speculum to have stainless steel
Reflecting surface.
By said program, the reflecting element includes an independent speculum and an independent reflecting surface, wherein
Reflecting surface is used to reflect or converge the laser exported from collimation focal element, and speculum is reflected super for reflecting or converging
Acoustical signal.
By said program, the reflecting surface is end face or the burnishing surface of the excitation fiber certain angle, described
Speculum have stainless steel reflecting surface.
By said program, the optical resonance element includes the optical resonator for having method promise resonance effect.
By said program, the optical resonator is the photonic crystal or reflected light of metallic surface plasma excimer
Grid.
Beneficial effects of the present invention are：
1,2 optical fiber and two light paths are selected to utilize ultrasonic wave by using the optical resonance element of compact high sensitivity
The characteristics of changing optical resonance elements resonant frequency, to realize the acquisition of signal, overall structure is simple, simplifies optics and sets
Meter so that device integration higher, miniaturization realize the acousto-optic of the full light of low cost, miniaturization, optical clear and high bandwidth
Signal acquisition greatly improves the existing fiberoptic ductoscopy technology clinically used.
2, optical resonance element is made using the technique of semiconductor nano coining by the end face in reception optical fiber, received
The fibre core of optical fiber is directly coupled with optical resonance element by grating coupler, reduces optical design difficulty and optics in probe
Coupling technique cost.
3, compared with the poly- membrane well of the Fabry Perot of the prior art, the optical resonance of the invention based on micro-ring resonant cavity
Element has higher quality factor, therefore has higher detectivity and image resolution ratio.In addition, by optimizing optics
Waveguide parameter in resonant element can also generate optical method promise resonance effects, form more steep resonance line, further increase
Detectivity and image resolution ratio.
4, when reception optical fiber, optical resonance element, reflecting element, collimation focal element and the fibre that shines are as a whole around capsule
Axis high speed rotation when, detectable signal can scan the appearance of 360 degree of biological tissue's inner wall, to realize high speed in real time at
Picture.
Description of the drawings
Fig. 1 is the structural schematic diagram of the first design of the prior art.
Fig. 2 is the structural schematic diagram of second of design of the prior art.
Fig. 3 is the structural schematic diagram of one embodiment of the invention.
Fig. 4 is the structural schematic diagram of optical resonance element in one embodiment of the invention.
Fig. 5 A are the resonance spectrum line chart of the optical resonance element of the prior art.
Fig. 5 B are the resonance spectrum line chart of the optical resonance element of one embodiment of the invention.
Fig. 6 is the structural schematic diagram of another embodiment of the present invention.
Fig. 7 is the structural schematic diagram of further embodiment of this invention.
In figure：Casing 1-1, single mode optical fiber 1-2, sound and light signal detection sensor 1-3, capsule 1-4；
Multimode fibre 2-1, flexure spring coil 2-2, matching pipe 2-3, focal element 2-4, reflecting element 2-5, ultrasound are changed
It can device 2-6, support component 2-7 and protective case 2-8；
Reception optical fiber 10, optical resonance element 20, reflecting element 30, collimation focal element 40, excitation fiber 50 and capsule
60；Micro-ring resonant cavity 21 connects waveguide 22 and grating coupler 23；First reflecting surface 31, the second reflecting surface 32, the first speculum
33, the second speculum 34, third reflecting surface 35, third speculum 36.
Specific implementation mode
With reference to specific example and attached drawing, the present invention will be further described.
Embodiment one：
The present invention provides a kind of Intraductal lesion imaging probe, is based on acousto-optic image-forming principle, as shown in figure 3, including optical fiber,
It includes excitation fiber 50 and reception optical fiber 10, this probe to collimate focal element 40, reflecting element 30 and capsule 60, the optical fiber
It further include the optical resonance element 20 for changing resonant frequency under the ultrasonic wave of return.The excitation fiber 50 receives
Optical fiber 10, the position relationship for collimating focal element 40, reflecting element 30, capsule 60 and optical resonance element 20 meet following optics
Path：Pulse laser is coupled into one end of excitation fiber 50, passes through collimation focal element in the other end of excitation fiber 50
40 focusing illuminations are focused on through capsule 60 under organism inner surface to 31 back reflection of the first reflecting surface of reflecting element 30, by
Ultrasonic signal is generated in acoustooptical effect, reflected ultrasonic signal is irradiated to the second reflection of reflecting element 30 through capsule 60
32 back reflection of face focuses on optical resonance element 20, changes the resonant frequency of optical resonance element 20；Detection light is coupled into
One end of reception optical fiber 10 is coupled into optical resonance element 20 in the other end of reception optical fiber 10, changes the spy of resonant frequency
It surveys light to reflect from reception optical fiber 10, three-dimensional imaging is carried out by optical detector and imaging unit.Wherein, the present invention changes
The detection principle only popped one's head in, is not directed to the improvement of imaging method, and image reconstruction in the prior art can be used in imaging method
Algorithm.
In the present embodiment, the excitation fiber 50, reception optical fiber 10, collimation focal element 40, reflecting element 30 and light
It learns resonant element 20 to be arranged in the capsule 60, and excitation fiber 50 and reception optical fiber 10 are located at the same of reflecting element 30
Side.
Further, the excitation fiber 50, reception optical fiber 10, collimation focal element 40, reflecting element 30 and optics
Resonant element 20 constitutes one can be around the entirety of the axial-rotation of the capsule 60.When reception optical fiber 10, optical resonance member
Part 20, reflecting element 30, collimation focal element 40, excitation fiber 50 as a whole around the axis high speed rotation of capsule 60 when, visit
The appearance of 360 degree of biological tissue's inner wall can be scanned by surveying signal, to realize high speed real time imagery.
Further, as shown in figure 4, the optical resonance element 20 includes the Planar integration waveguide for having elasto-optical effect
Device, Planar integration waveguide device are made of grating coupler 23, connection waveguide 22 and micro-ring resonant cavity 21；Planar integration waveguide
Device integral manufacturing is on the end face of reception optical fiber 10, and the grating coupler 23 is aligned with the core of reception optical fiber 10.
The Planar integration waveguide device is polymer material, and is produced on reception optical fiber 10 using semiconductor nano imprint process
On end face.The both ends of the grating coupler 23 connect from beginning to end with waveguide 22 is connect, the micro-ring resonant cavity 21 with connect
Certain gap is equipped between waveguide 22, and micro-ring resonant cavity 21 is arranged in the surface of grating coupler 23.When detection light
From the other end of reception optical fiber 10, connection waveguide 22 and the micro-ring resonant cavity of fiber end face are coupled by grating coupler 23
21, it then reflects and is coupled into reception optical fiber 10 again by grating coupler 23.With the Fabry Perot of the prior art
Poly- membrane well is compared, and the optical resonance element 20 of the invention based on micro-ring resonant cavity 21 has higher quality factor, therefore
Have higher detectivity and image resolution ratio.In addition, by optimizing waveguide parameter in optical resonance element 20, it can be with
Optical method promise resonance effects is generated, more steep resonance line is formed, further increases detectivity and image resolution ratio.
Fig. 5 A are the resonance line and detection optical wavelength of the optical resonance element of the prior art, and Fig. 5 B are the optics of the present invention
The resonance line of resonant element.The a length of λ of detection light wave of the prior art1, a length of λ of probing wave of the technology of the present invention2.It can from figure
To find out, when ultrasonic signal causes the resonance line of optical resonance element to move same distance, micro-ring resonant cavity of the invention
Due to method promise resonance effects generate resonance line it is more precipitous, detect change in optical signal amplitude bigger, detectivity and
Image resolution ratio higher.
Embodiment two：
The principle of the present embodiment is identical as embodiment one as structure, the difference is that：As shown in fig. 6, described is anti-
It includes 2 independent speculums to penetrate element 30；Wherein the first speculum 33 is for reflecting or converging from collimation focal element output
Laser, have optical reflection face；Second speculum 34 has stainless steel for reflecting or converging reflected ultrasonic signal
Reflecting surface.
Embodiment three：
The principle of the present embodiment is identical as embodiment one as structure, the difference is that：As shown in fig. 7, described is anti-
It includes an independent third speculum 36 and an independent third reflecting surface 35 to penetrate element 30, and wherein third reflecting surface 35 is used
In reflection or the laser exported from collimation focal element 40 is converged, can be 50 certain angle of excitation fiber (such as 45
Degree) end face or burnishing surface；Third speculum 36 has stainless steel anti-for reflecting or converging reflected ultrasonic signal
Penetrate face.
The reflecting surface or speculum of reflecting element 30 are processed by surface coating technique.
The optical resonance element 20 can also be other optical resonators with method promise resonance effect, such as metal
The photonic crystal or reflecting grating of surface plasmons.
Above example is merely to illustrate the design philosophy and feature of the present invention, and its object is to make technology in the art
Personnel can understand the content of the present invention and implement it accordingly, and protection scope of the present invention is not limited to the above embodiments.So it is all according to
According to equivalent variations or modification made by disclosed principle, mentality of designing, within protection scope of the present invention.
Claims (12)
1. a kind of Intraductal lesion imaging probe, including optical fiber, collimation focal element, reflecting element and capsule, it is characterised in that：
The optical fiber includes excitation fiber and reception optical fiber, this probe further includes for changing resonant frequency under the ultrasonic wave of return
Optical resonance element；
The position pass of the excitation fiber, reception optical fiber, collimation focal element, reflecting element, capsule and optical resonance element
System meets following optical path：Pulse laser is coupled into one end of excitation fiber, passes through standard in the other end of excitation fiber
Straight focal element focusing illumination is focused on through capsule under organism inner surface, to reflecting element back reflection due to acoustooptical effect
Ultrasonic signal is generated, reflected ultrasonic signal is irradiated to reflecting element back reflection through capsule and focuses on optical resonance member
Part changes the resonant frequency of optical resonance element；Detection light is coupled into one end of reception optical fiber, in the another of reception optical fiber
End is coupled into optical resonance element, and the detection light for changing resonant frequency is reflected from reception optical fiber, by optical detector and
Imaging unit carries out three-dimensional imaging.
2. Intraductal lesion imaging probe according to claim 1, it is characterised in that：The excitation fiber receives light
Fine, collimation focal element, reflecting element and optical resonance element are arranged in the capsule, and excitation fiber and reception light
Fibre is located at the same side of reflecting element.
3. Intraductal lesion imaging probe according to claim 2, it is characterised in that：The excitation fiber receives light
Fine, collimation focal element, reflecting element and optical resonance element constitute one can be around the whole of the axial-rotation of the capsule
Body.
4. Intraductal lesion imaging probe according to claim 1, it is characterised in that：The optical resonance element includes
Planar integration waveguide device with elasto-optical effect, Planar integration waveguide device are humorous by grating coupler, connection waveguide and micro-loop
The chamber that shakes is constituted；Planar integration waveguide device integral manufacturing is on the end face of reception optical fiber, and the grating coupler and reception
The core of optical fiber is aligned.
5. Intraductal lesion imaging probe according to claim 4, it is characterised in that：The Planar integration waveguide device
For polymer material, and it is produced on the end face of reception optical fiber using semiconductor nano imprint process.
6. Intraductal lesion imaging probe according to claim 4, it is characterised in that：The both ends of the grating coupler
It is connected with waveguide head and the tail are connect, certain gap, and micro-ring resonant cavity is equipped between the micro-ring resonant cavity and connection waveguide
Position is arranged in the surface of grating coupler.
7. Intraductal lesion imaging probe according to claim 1, it is characterised in that：The reflecting element includes 2
Independent speculum, wherein the first speculum is used to reflect or converge the laser exported from collimation focal element, the second speculum
For reflecting or converging reflected ultrasonic signal.
8. Intraductal lesion imaging probe according to claim 7, it is characterised in that：First speculum has light
Reflecting surface is learned, second speculum has stainless steel reflecting surface.
9. Intraductal lesion imaging probe according to claim 1, it is characterised in that：The reflecting element includes one
Independent speculum and an independent reflecting surface, wherein reflecting surface are used to reflect or converge to swash from what collimation focal element exported
Light, speculum is for reflecting or converging reflected ultrasonic signal.
10. Intraductal lesion imaging probe according to claim 9, it is characterised in that：The reflecting surface is described
The end face of excitation fiber certain angle or burnishing surface, the speculum have stainless steel reflecting surface.
11. Intraductal lesion imaging probe according to claim 1, it is characterised in that：The optical resonance element packet
Include the optical resonator with method promise resonance effect.
12. Intraductal lesion imaging probe according to claim 11, it is characterised in that：The optical resonator is gold
The photonic crystal or reflecting grating of metal surface plasmon.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810524691.3A CN108670177B (en) | 2018-05-28 | 2018-05-28 | Imaging probe of breast duct endoscope |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810524691.3A CN108670177B (en) | 2018-05-28 | 2018-05-28 | Imaging probe of breast duct endoscope |
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| CN108670177B CN108670177B (en) | 2020-09-01 |
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| CN201810524691.3A Active CN108670177B (en) | 2018-05-28 | 2018-05-28 | Imaging probe of breast duct endoscope |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109717838A (en) * | 2019-01-14 | 2019-05-07 | 于蓝 | Diagnostic device real-time servicing platform |
| CN110251053A (en) * | 2019-07-24 | 2019-09-20 | 文曼科技(深圳)有限公司 | A kind of dedicated endoscope of milk duct |
| CN110584570A (en) * | 2019-10-12 | 2019-12-20 | 深圳大学 | Endoscopic photoacoustic imaging system for all-optical detection |
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