CN116299837B - Preparation method of full-light type lateral photoinduced ultrasonic self-collecting optical fiber endoscope - Google Patents
Preparation method of full-light type lateral photoinduced ultrasonic self-collecting optical fiber endoscope Download PDFInfo
- Publication number
- CN116299837B CN116299837B CN202310007960.XA CN202310007960A CN116299837B CN 116299837 B CN116299837 B CN 116299837B CN 202310007960 A CN202310007960 A CN 202310007960A CN 116299837 B CN116299837 B CN 116299837B
- Authority
- CN
- China
- Prior art keywords
- optical fiber
- ultrasonic
- full
- multimode
- type lateral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000013307 optical fiber Substances 0.000 title claims abstract description 83
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000004793 Polystyrene Substances 0.000 claims abstract description 32
- 229920002223 polystyrene Polymers 0.000 claims abstract description 32
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 29
- 229910021389 graphene Inorganic materials 0.000 claims abstract description 29
- 239000002131 composite material Substances 0.000 claims abstract description 21
- 238000003384 imaging method Methods 0.000 claims abstract description 21
- 239000000835 fiber Substances 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 17
- 238000002604 ultrasonography Methods 0.000 claims abstract description 16
- 238000005516 engineering process Methods 0.000 claims abstract description 9
- 238000004544 sputter deposition Methods 0.000 claims abstract description 9
- 238000005530 etching Methods 0.000 claims abstract description 7
- 230000003287 optical effect Effects 0.000 claims abstract description 7
- 239000011248 coating agent Substances 0.000 claims abstract description 6
- 238000000576 coating method Methods 0.000 claims abstract description 6
- 238000012545 processing Methods 0.000 claims abstract description 6
- 238000003618 dip coating Methods 0.000 claims abstract description 5
- 230000008878 coupling Effects 0.000 claims abstract description 3
- 238000010168 coupling process Methods 0.000 claims abstract description 3
- 238000005859 coupling reaction Methods 0.000 claims abstract description 3
- 239000010410 layer Substances 0.000 claims description 13
- 229920000642 polymer Polymers 0.000 claims description 13
- 238000005520 cutting process Methods 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000011247 coating layer Substances 0.000 claims description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 6
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 6
- 239000011259 mixed solution Substances 0.000 claims description 6
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 6
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims description 6
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 6
- 230000001427 coherent effect Effects 0.000 claims description 5
- 238000006073 displacement reaction Methods 0.000 claims description 5
- 239000011358 absorbing material Substances 0.000 claims description 4
- 238000005253 cladding Methods 0.000 claims description 4
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 238000004528 spin coating Methods 0.000 claims description 3
- 230000002269 spontaneous effect Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 3
- 230000002792 vascular Effects 0.000 description 6
- 238000004140 cleaning Methods 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/02—Optical fibres with cladding with or without a coating
- G02B6/02057—Optical fibres with cladding with or without a coating comprising gratings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/07—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
- G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
- G02B23/2407—Optical details
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
- G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
- G02B23/26—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes using light guides
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/02—Optical fibres with cladding with or without a coating
- G02B6/02057—Optical fibres with cladding with or without a coating comprising gratings
- G02B6/02076—Refractive index modulation gratings, e.g. Bragg gratings
- G02B6/0208—Refractive index modulation gratings, e.g. Bragg gratings characterised by their structure, wavelength response
- G02B6/021—Refractive index modulation gratings, e.g. Bragg gratings characterised by their structure, wavelength response characterised by the core or cladding or coating, e.g. materials, radial refractive index profiles, cladding shape
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/02—Optical fibres with cladding with or without a coating
- G02B6/02057—Optical fibres with cladding with or without a coating comprising gratings
- G02B6/02076—Refractive index modulation gratings, e.g. Bragg gratings
- G02B6/02123—Refractive index modulation gratings, e.g. Bragg gratings characterised by the method of manufacture of the grating
Abstract
The invention discloses a preparation method of an all-optical type lateral photo-induced ultrasonic self-receiving optical fiber endoscope, which comprises the following steps: 1) Selecting multimode optical fibers with moderate lengths and performing end face treatment; 2) Etching a 45-degree inclined grating on a fiber core near the end face of the optical fiber by adopting a micro-nano optical technology, so that pulse laser transmitted by the optical fiber is deflected by 90 degrees; 3) Manufacturing an F-P resonant cavity on the end face of the optical fiber by adopting sputtering and dip-coating methods so as to detect a photoinduced ultrasonic echo signal; 4) Coating a graphene array and polystyrene composite material at the emergent position of multimode fiber inclined grating pulse laser as a photoinduced ultrasonic transducer to generate a photoinduced ultrasonic signal for endoscopic imaging; 5) Coupling pulse laser for exciting ultrasound and continuous laser for detecting ultrasound into the multimode optical fiber, and realizing an endoscopic imaging function by matching with a three-dimensional rotary moving platform and a signal processing and control system; simple process, convenient operation and good performance.
Description
Technical Field
The invention belongs to the technical field of ultrasound, and particularly relates to a preparation method of an all-optical type lateral photoinduced ultrasonic self-retracting optical fiber endoscope.
Background
Ultrasound has the advantages of strong penetrability, high safety, good real-time performance, low price, convenient use and the like, and plays an important role in diagnosis and treatment of clinical diseases. Ultrasonic endoscopic imaging can provide detailed tissue visualization information, and can provide certain guidance and assistance for clinical diagnosis and operation. The traditional ultrasonic endoscope uses a piezoelectric transducer, and the interaction of energy and information between electricity and sound is realized by means of the piezoelectric and inverse piezoelectric characteristics of materials. However, as the understanding and research of the effect of the photo-induced ultrasound is gradually in progress, the photo-induced ultrasound endoscope is expected to be a powerful complement to the conventional ultrasound endoscope. The photoinduced ultrasonic transducer belongs to an optical driving device, and generates ultrasonic signals by irradiating a photoinduced ultrasonic material with pulse laser, and can receive and read ultrasonic echo signals by combining an optical fiber technology.
Compared with the traditional piezoelectric device, the size of the photoinduced ultrasonic optical fiber endoscope mainly depends on the diameter of the optical fiber, and can reach about 200 mu m. And the full-light type photoinduced ultrasonic optical fiber endoscope is not affected by electromagnetic interference, and is an optical driving device without considering the problem of electric connection, so that the full-light type photoinduced ultrasonic optical fiber endoscope has great advantages in endoscopic ultrasonic imaging. Existing photo-ultrasonic fiber endoscopes are typically forward mode, i.e., emit ultrasonic signals through the fiber-optic front end. The device in the mode is generally difficult to meet the lateral imaging requirement in endoscopic imaging, and meanwhile, other devices are required to be used for detecting the ultrasonic echo signals, so that the size and assembly difficulty of the endoscope are increased, and the practical application is not facilitated.
Disclosure of Invention
The invention aims to solve the technical problems in the background technology, and aims to provide a preparation method of an all-optical lateral photoinduced self-retracting optical fiber endoscope, which solves the problems of narrow bandwidth, low imaging resolution, large size, complex system and the like of an ultrasonic endoscope.
A method for preparing an all-optical type lateral photo-induced ultrasonic self-receiving optical fiber endoscope, which comprises the following steps:
s1: etching an inclined grating on a fiber core at a position, close to the end face, of one end of the multimode fiber with a flat end face by utilizing a micro-nano optical technology;
s2: sputtering a layer of semi-transparent semi-reflective film on the end face of the multimode fiber with the inclined grating, then dip-coating a layer of transparent polymer as a cavity of the F-P interferometer, and then sputtering a layer of total reflective film on the surface of the polymer to prepare the F-P interferometer;
s3: the light absorbing material and the thermal expansion material are coated on the surface of the cladding at the emergent position of the inclined grating pulse laser to be used as a photoinduced ultrasonic transducer to generate a photoinduced ultrasonic signal for endoscopic imaging.
Further, before step S1, the method further comprises:
selecting a multimode optical fiber, removing coating layers near two ends of the multimode optical fiber, wiping the coating layers with alcohol, and cutting two end faces of the multimode optical fiber by using an optical fiber cutting machine to obtain the multimode optical fiber with flat end faces.
Further, after step S3, the method further comprises:
and coupling pulse laser for exciting ultrasound and continuous laser for detecting ultrasound into the other end face of the multimode optical fiber far away from the inclined grating, and building a lateral photo-induced ultrasound spontaneous self-receiving optical fiber endoscope by matching with a three-dimensional rotary moving platform and a signal processing and control system.
Further, a precise micro-displacement platform and a coherent ultraviolet laser are utilized to etch a reflective 45-degree inclined grating on a fiber core at a position, close to the end face, of one end of the multimode optical fiber with a flat end face, so that the propagation direction of pulse laser is changed, and the pulse laser is emitted from the side face of the optical fiber.
Further, the prepared F-P interferometer is used for detecting high-frequency and broadband photoinduced ultrasonic.
Further, the light absorbing material adopts a graphene array; the thermal expansion material polystyrene.
Further, the graphene array and polystyrene composite material are coated at the emergent position of the inclined grating pulse laser on the surface of the cladding, and then the graphene array and polystyrene composite material are cured; the pulse laser emitted from the side surface of the optical fiber is made to enter the composite material coating to produce high-frequency, broadband and high-efficiency photoinduced ultrasonic.
Further, the transparent polymer may be made of materials including: PDMS.
Further, the preparation step of the graphene array and polystyrene composite material comprises the following steps:
preparing a polystyrene mixed solution, wherein the mixed solution comprises polystyrene and a toluene solvent;
and (3) dripping the polystyrene mixed liquid on the surface of the grown graphene array, performing spin coating to uniformly spread the whole graphene array film surface, and then solidifying in a vacuum environment, wherein the graphene array and the solidified polystyrene form a graphene array and polystyrene composite material.
In order to solve the technical problems, the technical scheme of the invention is as follows:
compared with the prior art, the invention has the advantages that:
1) The size of the full-light type lateral photo-induced ultrasonic self-retracting optical fiber endoscope is small and can reach about 200 mu m. Compared with the traditional piezoelectric ultrasonic endoscope, the full-light type lateral photoinduced ultrasonic self-collecting optical fiber endoscope has the advantages of wide frequency band, high imaging resolution, simple preparation process, no electric connection, electromagnetic interference resistance and the like;
2) The side-emitting photoinduced ultrasonic signals are realized through the reflective 45-degree inclined grating, so that the imaging requirement of an endoscopic imaging section is met;
3) The photoinduced ultrasonic emitter and the detector are integrated on the same multimode optical fiber, so that the self-receiving function of the photoinduced ultrasonic of a single optical fiber is realized, and the size and the packaging difficulty of the endoscope are reduced.
Drawings
FIG. 1 is a flow chart of a preparation method of an all-optical type lateral photo-induced ultrasonic self-retracting optical fiber endoscope;
FIG. 2 is a schematic diagram of the structure of the present invention for etching a reflective 45 oblique grating in a multimode fiber;
FIG. 3 is a schematic diagram of the structure of the F-P interferometer fabricated on the end face of a multimode fiber in accordance with the present invention;
FIG. 4 is a schematic diagram of the structure of a photo-ultrasonic transducer fabricated on the side of a multimode optical fiber in accordance with the present invention;
FIG. 5 is a schematic diagram of the use of an all-optical lateral photo-induced ultrasonic self-retracting fiber optic endoscope made in accordance with the present invention;
FIG. 6 is a photo-induced ultrasonic signal waveform (left) and spectrum (right);
fig. 7 is a point-by-point scan (up) and cross-sectional view (down) of a vascular proxy imaging.
Detailed Description
The following describes specific embodiments of the present invention with reference to examples:
it should be noted that the structures, proportions, sizes and the like illustrated in the present specification are used for being understood and read by those skilled in the art in combination with the disclosure of the present invention, and are not intended to limit the applicable limitations of the present invention, and any structural modifications, proportional changes or size adjustments should still fall within the scope of the disclosure of the present invention without affecting the efficacy and achievement of the present invention.
Also, the terms such as "upper," "lower," "left," "right," "middle," and "a" and the like recited in the present specification are merely for descriptive purposes and are not intended to limit the scope of the invention, but are intended to provide relative positional changes or modifications without materially altering the technical context in which the invention may be practiced.
Example 1:
the advantages of the present invention, with respect to patent CN 112858180A, are:
1. the graphene array and polystyrene composite material adopted by the invention further improves the center frequency and bandwidth of the photoinduced ultrasonic signal, has the capability of generating higher-frequency photoinduced ultrasonic signals under the action of narrow pulse width pulse laser, and is beneficial to improving the resolution of ultrasonic imaging;
2. the structure designed by the invention has simple preparation process, can ensure the integrity of the optical fiber, has better toughness, mechanical strength and anti-interference capability, is beneficial to integration and encapsulation, and is suitable for wider application scenes.
FIG. 1 is a flow chart of a preparation method of an all-optical type lateral photo-induced ultrasonic self-retracting optical fiber endoscope; as shown in fig. 1, the method comprises the following steps:
s101, selecting multimode optical fibers with moderate lengths and performing end face treatment;
s102, etching a reflective 45-degree inclined grating on a fiber core near one end of a multimode fiber by using a precise micro-displacement platform and a coherent ultraviolet laser by adopting a phase mask technology; turning 532nm pulsed laser 90 °;
s103, sputtering a semi-transparent semi-reflective film on the same end face of the optical fiber, then dip-coating a transparent polymer layer as a cavity of the F-P interferometer, and then sputtering a total reflective film layer on the surface of the polymer layer to prepare the F-P interferometer so as to detect ultrasonic echo signals;
and S104, coating the grown graphene array and polystyrene composite material on the emergent position of the reflection type 45-degree inclined grating pulse laser to obtain the full-light type lateral photo-induced ultrasonic spontaneous self-collecting optical fiber endoscope.
Optionally, the graphene array and polystyrene composite material is prepared by the following steps:
preparing a polystyrene mixed solution, wherein the mixed solution comprises polystyrene and a toluene solvent;
dropping polystyrene mixed liquid on the surface of a grown graphene array, performing spin coating to uniformly spread the whole surface of the graphene array film, and then solidifying in a vacuum environment, wherein the graphene array and solidified polystyrene form a graphene array and polystyrene composite material;
alternatively, in the process of preparing the F-P interferometer, the transparent polymer used as the cavity of the F-P interferometer can be selected from PDMS and the like.
The invention provides a preparation method of an all-optical type lateral photoinduced ultrasonic optical fiber endoscope, which adopts a micro-nano optical technology to combine an inclined grating, an F-P resonant cavity, a graphene array and a polystyrene composite material, and realizes the all-optical type lateral photoinduced ultrasonic optical fiber endoscope on a single multimode optical fiber.
In order to achieve the above object, according to the present invention, there is provided a method for preparing an all-optical type lateral photo-induced ultrasonic self-retracting optical fiber endoscope, which is characterized by comprising the steps of:
1) And selecting a multimode optical fiber with moderate length, wherein the length of the multimode optical fiber is 2m, and the core diameter is 200 mu m.
2) And removing coating layers at two ends of the multimode optical fiber, cleaning the multimode optical fiber by alcohol and deionized water, cutting the multimode optical fiber by using an optical fiber cutting machine, and cleaning the multimode optical fiber by alcohol and deionized water again to clean and level the surfaces of the multimode optical fiber so as to better transmit laser and carry out subsequent treatment.
3) The reflective 45-degree inclined grating is etched at the position of the multimode optical fiber, which is 5mm away from the end face, by adopting a micro-nano optical technology, and the structure of the reflective 45-degree inclined grating is shown in figure 2.
4) As shown in FIG. 3, a semi-transparent semi-reflective film is sputtered on the same end face of the optical fiber, then a layer of PDMS with the thickness of about 5 μm is dip-coated as a cavity of the F-P interferometer, and then a layer of total reflective film is sputtered on the surface of the polymer to manufacture the F-P interferometer.
5) The grown graphene array and polystyrene composite material are coated at the emergent position of the reflective 45-degree inclined grating pulse laser, as shown in fig. 4.
6) The pulse laser of the excitation light induced ultrasonic and the continuous laser of the detection light induced ultrasonic are coupled into the multimode optical fiber, and the three-dimensional rotary moving platform and the signal processing and control system are matched to realize the light induced ultrasonic endoscopic imaging function, as shown in fig. 5.
Preferably, the preparation of the reflective 45 ° oblique grating in step 3) is performed by etching at the multimode fiber core using a precision micro-displacement platform and a coherent uv laser using a phase mask technique.
Preferably, the F-P interferometer in step 4) is fabricated using a transparent polymer PDMS as the cavity of the F-P interferometer, but is not limited to this transparent polymer.
Preferably, in step 5), the graphene array and polystyrene composite material is coated at the emergent position of the oblique grating pulse laser, and the thickness of the composite material is controlled to be about 10 μm, but is not limited to the thickness.
The invention provides a preparation process flow of an all-optical type lateral photoinduced ultrasonic optical fiber endoscope. The method has simple process flow, not only utilizes the graphene array and the polystyrene composite material to generate high-frequency photoinduced ultrasound, but also combines the inclined grating and the F-P resonant cavity on a single multimode optical fiber to realize the self-collecting all-optical type lateral photoinduced ultrasound optical fiber endoscope.
Example 2:
in a specific embodiment, the example steps are as follows:
1) The method comprises the steps of processing the end face of an optical fiber, selecting a multimode optical fiber with the length of 2m and the core diameter of 200 mu m, removing coating layers at two ends of the multimode optical fiber, cleaning the multimode optical fiber by alcohol and deionized water, cutting the multimode optical fiber by an optical fiber cutting machine, and cleaning the multimode optical fiber by alcohol and deionized water again to clean and level the surface of the multimode optical fiber;
3) Etching a reflective 45-degree inclined grating at a position 5mm away from the end face of the multimode fiber by using a precise micro-displacement platform and a coherent ultraviolet laser by adopting a phase mask technology;
4) Sputtering a semi-transparent semi-reflective film on the same end face of the optical fiber, dip-coating a layer of PDMS with the thickness of about 5 mu m as a cavity of the F-P interferometer, and sputtering a layer of total reflective film on the surface of the polymer;
5) And coating the grown graphene array and polystyrene composite material on the emergent position of the reflecting 45-degree inclined grating pulse laser to prepare the full-light type lateral photo-induced ultrasonic self-emitting and self-receiving optical fiber endoscope.
Example 3:
for a specific manufacturing device, the photoacoustic performance of the device is tested, pulse laser exciting ultrasound is coupled to the device, an optical fiber hydrophone probe is placed at a position 1.5mm away from the surface of a photoinduced ultrasonic emitter, when the pumping current is 50A, the waveform and the pressure of an ultrasonic signal are shown as shown in figure 6, the peak-to-peak value of the output ultrasonic signal is 0.98V (-1.6 MPa), the corresponding-6 db ultrasonic bandwidth is about 16MHz, and the center frequency is about 16MHz. The result shows that the manufactured device can generate broadband high-frequency ultrasonic waves, has enough signal intensity and can meet the requirement of intravascular ultrasonic imaging.
The pulse laser for exciting the ultrasonic and the continuous laser for detecting the ultrasonic are coupled into the device, and an endoscopic imaging experiment is carried out on the vascular imitation body by matching with the three-dimensional rotary moving platform and the signal processing and control system so as to prove the capability of imaging the vascular imitation body in the blood vessel. The device was fixed and packaged and rotated at 6 intervals, and a 360-degree rotation imaging was performed on the vascular mimics. As shown in fig. 7, it can be seen that the imaging result has good contrast, and at the same time, a high penetration depth is maintained, so that the inner and outer boundaries of the vascular imitation can be clearly distinguished. The measured cavity has an inner diameter of about 5.5mm and an outer diameter of about 7mm, and is well matched with the actual size of the vascular imitation. The obtained data fully show the potential of the device in full-gloss type photoinduced ultrasonic endoscopic imaging.
While the preferred embodiments of the present invention have been described in detail, the present invention is not limited to the above embodiments, and various changes may be made without departing from the spirit of the present invention within the knowledge of those skilled in the art.
Many other changes and modifications may be made without departing from the spirit and scope of the invention. It is to be understood that the invention is not to be limited to the specific embodiments, but only by the scope of the appended claims.
Claims (8)
1. The preparation method of the full-light type lateral photo-induced ultrasonic self-collecting optical fiber endoscope is characterized by comprising the following steps of:
s1: etching an inclined grating on a fiber core at a position, close to the end face, of one end of the multimode fiber with a flat end face by utilizing a micro-nano optical technology;
s2: sputtering a layer of semi-transparent semi-reflective film on the end face of the multimode fiber with the inclined grating, then dip-coating a layer of transparent polymer as a cavity of the F-P interferometer, and then sputtering a layer of total reflective film on the surface of the polymer to prepare the F-P interferometer;
s3: coating a light absorbing material and a thermal expansion material on the surface of a cladding at the emergent position of the inclined grating pulse laser as a photoinduced ultrasonic transducer to generate a photoinduced ultrasonic signal for endoscopic imaging; the light absorbing material adopts a graphene array; the thermal expansion material polystyrene.
2. The method for preparing the full-gloss type lateral photo-induced ultrasonic self-retracting optical fiber endoscope according to claim 1, wherein before step S1, the method further comprises:
selecting a multimode optical fiber, removing coating layers near two ends of the multimode optical fiber, wiping the coating layers with alcohol, and cutting two end faces of the multimode optical fiber by using an optical fiber cutting machine to obtain the multimode optical fiber with flat end faces.
3. The method for preparing the full-gloss type lateral photo-induced ultrasonic self-retracting optical fiber endoscope according to claim 1, wherein after step S3, the method further comprises:
and coupling pulse laser for exciting ultrasound and continuous laser for detecting ultrasound into the other end face of the multimode optical fiber far away from the inclined grating, and building a lateral photo-induced ultrasound spontaneous self-receiving optical fiber endoscope by matching with a three-dimensional rotary moving platform and a signal processing and control system.
4. The preparation method of the full-optical type lateral photo-induced ultrasonic self-receiving optical fiber endoscope is characterized in that a precise micro-displacement platform and a coherent ultraviolet laser are utilized to etch a reflective 45-degree inclined grating on a fiber core at a position, close to the end face, of one end of a multimode optical fiber with a flat end face.
5. The preparation method of the full-gloss type lateral photoinduced ultrasonic self-receiving optical fiber endoscope, which is characterized in that the F-P interferometer is used for detecting high-frequency and broadband photoinduced ultrasonic.
6. The preparation method of the full-gloss type lateral photoinduced ultrasonic self-collecting optical fiber endoscope is characterized in that after a graphene array and polystyrene composite material is coated at an inclined grating pulse laser emergent position on the surface of a cladding, the graphene array and the polystyrene composite material are solidified; the pulse laser emitted from the side surface of the optical fiber is made to enter the composite material coating to generate the photo-induced ultrasonic.
7. The method for preparing the full-gloss type lateral photo-induced ultrasonic self-generating optical fiber endoscope according to claim 1, wherein the transparent polymer comprises the following materials: PDMS.
8. The method for preparing the full-gloss type lateral photo-induced ultrasonic self-generating and self-receiving optical fiber endoscope according to claim 6, wherein the step of preparing the graphene array and polystyrene composite material comprises the following steps:
preparing a polystyrene mixed solution, wherein the mixed solution comprises polystyrene and a toluene solvent;
and (3) dripping the polystyrene mixed liquid on the surface of the grown graphene array, performing spin coating to uniformly spread the whole graphene array film surface, and then solidifying in a vacuum environment, wherein the graphene array and the solidified polystyrene form a graphene array and polystyrene composite material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310007960.XA CN116299837B (en) | 2023-01-04 | 2023-01-04 | Preparation method of full-light type lateral photoinduced ultrasonic self-collecting optical fiber endoscope |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310007960.XA CN116299837B (en) | 2023-01-04 | 2023-01-04 | Preparation method of full-light type lateral photoinduced ultrasonic self-collecting optical fiber endoscope |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116299837A CN116299837A (en) | 2023-06-23 |
| CN116299837B true CN116299837B (en) | 2024-03-15 |
Family
ID=86793129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310007960.XA Active CN116299837B (en) | 2023-01-04 | 2023-01-04 | Preparation method of full-light type lateral photoinduced ultrasonic self-collecting optical fiber endoscope |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116299837B (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105011890A (en) * | 2015-06-15 | 2015-11-04 | 深圳先进技术研究院 | Photo-acoustic endoscopic apparatus based on graded-index optical fiber |
| WO2016101280A1 (en) * | 2014-12-26 | 2016-06-30 | 深圳先进技术研究院 | Intravascular imaging system and method |
| CN105769128A (en) * | 2016-05-06 | 2016-07-20 | 华南师范大学 | Integrated opto-acoustic, ultrasonic and opto-acoustic elastic endoscopic imaging device and method thereof |
| KR20180077966A (en) * | 2016-12-29 | 2018-07-09 | 울산과학기술원 | Photoacoustic and ultrasonic endoscopic mini-probe |
| CN108670177A (en) * | 2018-05-28 | 2018-10-19 | 武汉大学 | A kind of Intraductal lesion imaging probe |
| CN212307814U (en) * | 2020-04-07 | 2021-01-08 | 中国科学院苏州生物医学工程技术研究所 | Multi-mode microscopic endoscopic imaging device |
| CN112493997A (en) * | 2020-11-30 | 2021-03-16 | 中国科学院深圳先进技术研究院 | Photoacoustic endoscopic imaging device and photoacoustic endoscopic imaging method based on same |
| CN112858180A (en) * | 2021-01-12 | 2021-05-28 | 北京航空航天大学 | Integrated optical fiber type photoacoustic probe capable of lateral ultrasonic excitation and detection |
| CN113080869A (en) * | 2021-04-12 | 2021-07-09 | 北京航空航天大学 | Ultrasonic imaging probe |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9351705B2 (en) * | 2009-01-09 | 2016-05-31 | Washington University | Miniaturized photoacoustic imaging apparatus including a rotatable reflector |
| KR101994937B1 (en) * | 2017-02-15 | 2019-07-01 | 울산과학기술원 | Array transducer-based side-scanning photoacoustic and ultrasonic endoscopy system |
-
2023
- 2023-01-04 CN CN202310007960.XA patent/CN116299837B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016101280A1 (en) * | 2014-12-26 | 2016-06-30 | 深圳先进技术研究院 | Intravascular imaging system and method |
| CN105011890A (en) * | 2015-06-15 | 2015-11-04 | 深圳先进技术研究院 | Photo-acoustic endoscopic apparatus based on graded-index optical fiber |
| CN105769128A (en) * | 2016-05-06 | 2016-07-20 | 华南师范大学 | Integrated opto-acoustic, ultrasonic and opto-acoustic elastic endoscopic imaging device and method thereof |
| KR20180077966A (en) * | 2016-12-29 | 2018-07-09 | 울산과학기술원 | Photoacoustic and ultrasonic endoscopic mini-probe |
| CN108670177A (en) * | 2018-05-28 | 2018-10-19 | 武汉大学 | A kind of Intraductal lesion imaging probe |
| CN212307814U (en) * | 2020-04-07 | 2021-01-08 | 中国科学院苏州生物医学工程技术研究所 | Multi-mode microscopic endoscopic imaging device |
| CN112493997A (en) * | 2020-11-30 | 2021-03-16 | 中国科学院深圳先进技术研究院 | Photoacoustic endoscopic imaging device and photoacoustic endoscopic imaging method based on same |
| CN112858180A (en) * | 2021-01-12 | 2021-05-28 | 北京航空航天大学 | Integrated optical fiber type photoacoustic probe capable of lateral ultrasonic excitation and detection |
| CN113080869A (en) * | 2021-04-12 | 2021-07-09 | 北京航空航天大学 | Ultrasonic imaging probe |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116299837A (en) | 2023-06-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11647957B2 (en) | Ultrasound probe | |
| EP1471848B1 (en) | Ultrasonic transducer probe | |
| JP3628026B2 (en) | Method and apparatus for optical measurement using optical fiber imaging guidewire, catheter or endoscope | |
| US20140180128A1 (en) | Focused Rotational IVUS Transducer Using Single Crystal Composite Material | |
| EP2675361A2 (en) | Photoacoustic probe | |
| US20110144502A1 (en) | Imaging guidewire | |
| US20210251605A1 (en) | Ultrasound imaging probe | |
| CN112345459B (en) | Receiving and transmitting integrated optical fiber ultrasonic probe and ultrasonic excitation and detection system | |
| Zhang et al. | Backward-mode photoacoustic imaging using illumination through a CMUT with improved transparency | |
| CN106037663B (en) | A kind of continuous vari-focus ultrasonic probe and its Zooming method | |
| US20130245378A1 (en) | Rotating catheter probe using a light-drive apparatus | |
| Li et al. | Dynamic acoustic focusing in photoacoustic transmitter | |
| Li et al. | High-sensitivity low-frequency Fabry-Perot ultrasonic hydrophone with Chitosan diaphragm | |
| Guo et al. | Validation of an ultrasound transducer's generation and receiving function on one single-mode fiber | |
| CN116299837B (en) | Preparation method of full-light type lateral photoinduced ultrasonic self-collecting optical fiber endoscope | |
| Yang et al. | Miniaturized fiber optic ultrasound sensor with multiplexing for photoacoustic imaging | |
| CN114010151B (en) | Photoacoustic ultrasound multi-mode imaging system | |
| Ashkenazi et al. | High frequency optoacoustic transducers for ultrasonic and photoacoustic imaging | |
| Acquafresca et al. | Toward virtual biopsy through an all fiber optic ultrasonic miniaturized transducer: a proposal | |
| CN112858180B (en) | Integrated optical fiber type photoacoustic probe capable of lateral ultrasonic excitation and detection | |
| CN113081043B (en) | Ultrasonic imaging detector | |
| CN113080869B (en) | Ultrasonic imaging probe | |
| Sheaff et al. | A fiber optic optoacoustic ultrasound sensor for photoacoustic endoscopy | |
| Du et al. | Fiber optic photoacoustic-based steering imaging transducer | |
| Ashkenazi et al. | High frequency ultrasound imaging using Fabry-Perot optical etalon |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |