CN106690313A - Throat heat-clearing and alcohol-dispelling tablet - Google Patents
Throat heat-clearing and alcohol-dispelling tablet Download PDFInfo
- Publication number
- CN106690313A CN106690313A CN201710012738.3A CN201710012738A CN106690313A CN 106690313 A CN106690313 A CN 106690313A CN 201710012738 A CN201710012738 A CN 201710012738A CN 106690313 A CN106690313 A CN 106690313A
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- CN
- China
- Prior art keywords
- parts
- clearing
- sobering
- buccal tablet
- stem cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000000130 stem cell Anatomy 0.000 claims abstract description 31
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 21
- 230000028327 secretion Effects 0.000 claims abstract description 21
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 20
- 239000002994 raw material Substances 0.000 claims abstract description 11
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
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- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
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- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a throat heat-clearing and alcohol-dispelling tablet which comprises the following raw materials in parts by weight: 6-9 parts of a sweetening agent, 1-4 parts of menthol, 2-4 parts of citric acid, 2-5 parts of magnesium stearate and 60-80 parts of a radix pueraria stem cell secretion factor. The invention further discloses a preparation method of the radix pueraria stem cell secretion factor and a preparation method of the throat heat-clearing and alcohol-dispelling tablet. Compared with the prior art, the throat heat-clearing and alcohol-dispelling tablet disclosed by the invention has the benefits that the radix pueraria stem cell secretion factor is obtained through the culture of radix pueraria stem cells, so that effective alcohol-dispelling ingredients in radix pueraria can be maximally extracted; alcohol dehydrogenase (ADH) in an intoxicated person body is significantly improved; free radicals are quickly cleared away; the throat heat-clearing and alcohol-dispelling tablet is safe, free from side effect and convenient to eat and carry.
Description
Technical field
The invention belongs to health product technology field, and in particular to a kind of clearing Sobering-up buccal tablet.
Background technology
Characters of Chinese Alcoholic Drink Culture is of long standing and well established, responsible drinking, can be promoting blood circulation and removing obstruction in channels, and cardiac stimulant is refreshed oneself, dispelling fatigue, promotes sleep.But
It is, with the increase of modern life pressure and a kind of social required, the mode as groups of people's life of drinking, and then because of excessive drinking
The a series of problems for causing also is come one after the other, such as damage liver, stomach, spleen internal organs, may cause phrenoblabia, gastric ulcer,
The diseases such as fatty liver, alcoholic hepatitis and cirrhosis.Safely and effectively alcohol-neutralize healthy product is the current focus studied for exploitation.
Chinese patent CN106072636A discloses the Sobering-up buccal tablet and its production method with Camellia nitidissima as raw material, its feature
It is to be made up of active ingredient and auxiliary material, the weight portion of the raw material of the active ingredient is as follows：Golden camellia tea or camellia 15-25
20-40 parts, rhizoma imperatae 10-20 parts, chrysanthemum 15-30 parts of part, root of kudzu vine leaf or flower.The patent also discloses a kind of with Camellia nitidissima as former
The production method of the Sobering-up buccal tablet of material, it is characterised in that：Comprise the following steps that：By the weight portion of raw material take golden camellia tea or
Camellia, root of kudzu vine leaf or flower, rhizoma imperatae and chrysanthemum；Clean and dry, grind, be subsequently adding the 20-25 times of water of weight, decoct
20-30 minutes, filtrate is filtered to take, add the 2-3 times of absolute ethyl alcohol of weight, stand 2-3 hours, collect the supernatant after alcohol precipitation
Liquid, finally to addition yam flour and coarse rice powder in supernatant；By the supernatant containing yam flour and coarse rice powder in step (1) with very
Sky is concentrated into paste, and is granulated, dried and whole grain treatment；In particle after step (2) whole grain other residues will be added auxiliary
Material, uniform stirring mixing；Finally granulated, compressing tablet, packing processes obtain finished product.
Chinese patent CN105394472A, including step is as follows：1) raw material of following mass parts are mixed and is ground to form
Powdery, parts by weight of raw materials is as follows：6~8 parts of hawthorn, 10~12 parts of the black certain kind of berries, 6~8 parts of lotus, 2~4 parts of nutmeg, sour pomegranate 1~
2 parts, 10~15 parts of the root of kudzu vine, 4~8 parts of honeysuckle, 10~12 parts of wrinkled giant hyssop, 6~12 parts of honey raisin tree, 1~3 part of Momordica grosvenori, French beans 1~3
Part, mixed powder is obtained；2) by step 1) obtained in mixed powder add 1~3 times of water, obtain mixed solution, then in 70~
80 DEG C of heating infusions, while being stirred continuously, when mixed liquor volume is after adding water 1/3~1/2, stop heating；3) heat
Mixed solution centrifugation removal solid matter afterwards, extracts clear liquid；4) clear liquid is concentrated into paste；5) by paste drying to powder
Shape, adds 1~2 part of microcrystalline cellulose, and 1~2 part of lactose, 1~2 part of mannitol, 1~2 part of hydroxypropyl cellulose, hydroxypropyl is fine
1~2 part of dimension element, 1~2 part of magnesium stearate auxiliary material；6) by step 5) it is well mixed, granulation, compressing tablet obtains final product Sobering-up buccal tablet.
Sobering-up buccal tablet majority of the prior art is prepared into by extracting the active ingredient in adult plants and then processing
Lozenge, because plant nutrient ingredient complexity is various, current extracting method yield is low be also easily destroyed plant nutrition in itself into
Point, finally cause that dispelling effects of alcohol is not satisfactory.
The content of the invention
For the above-mentioned problems in the prior art, it is an object of the invention to provide a kind of clearing Sobering-up buccal tablet, with
Phase, by cultivating root of kudzu vine stem cell, extracts its stem cell secretion thing, and increases effectively relieve the effect of alcohol the containing of composition in lozenge to greatest extent
Amount, and then improve dispelling effects of alcohol.
For achieving the above object, the technical solution adopted by the present invention is as follows：
A kind of clearing Sobering-up buccal tablet, including following portions by weight raw material：Sweetener 6-9 parts, menthol 1-4 parts, lemon
It is sour 2-4 parts, magnesium stearate 2-5 parts, it is characterised in that also including 60-80 parts of root of kudzu vine stem cell secretion factor.
The sweetener can select the sucrose free sweeteners such as fructose, honey element, xylitol or maltitol.
The root of kudzu vine stem cell secretion factor is to be prepared by the following method gained：The newborn root of kudzu vine is taken, 0.5-0.8% is used
Bravo surface sterilizing after cut；Tissue containing forming layer, bast, cortex and epidermis is lightly shelled from xylem
From；The culture on solid-state isolation medium that is organized in that will be obtained, 18-22 DEG C of cultivation temperature, newborn formation after culture 28-30d
Stem cell is separated layer with the callus of dedifferentiation, and the forming layer stem cell of acquisition is transferred on liquid growth medium, with
19-21d is cultivated at 80-110rpm, 18-22 DEG C；The cell line of acquisition continues to amplify culture 21-23d, culture period at 18-22 DEG C
Between uninterruptedly stir；Cell line obtained by culture retains macromolecular mass through ultrafiltration, is cleaned by ultrasonic after crushing macromolecular mass cell line
Rotation is emptied evaporation, and vacuum freeze drying obtains final product root of kudzu vine stem cell secretion factor.
Described solid-state isolation medium is MS solid medium+6-BA0.8-1.2mg/L+2,4-D 0.8-1.2mg/L+
NAA0.1-0.3mg/L。
Described liquid growth medium is MS liquid culture medium+6-BA0.8-1.2mg/L+2,4-D 0.1-0.3mg/L.
Further, the preparation method of the clearing Sobering-up buccal tablet is：By sweetener 6-9 parts, menthol 1-4 parts, citric acid
2-4 parts, magnesium stearate 2-5 parts, 60-80 parts of root of kudzu vine stem cell secretion factor smashes mixing, granulation, and compressing tablet is that clearing must relieve the effect of alcohol and contain
Piece.
The root of kudzu vine (Pueraria lobata) is the dry root of legume pueraria lobata, and main component is Puerarin, daidzein
It is China's tradition Sobering-up Chinese medicine Deng isoflavonoid.《Haigoushen》Described in:Gas on day row is controlled, is vomitted inverse, whetting the appetite,
Principal solution wine poison, only polydipsia；Control asthenia gastropyrexia thirsty, wine poison vomiting.Puerarin is reducing ethanol into blood and enhancing alcohol levels in blood samples generation
Thanking to aspect has good effect, and other isoflavones also have functions that to cooperate with relieving alcoholism and preventing drunkenness.Relieving mechanism is to improve alcohol dehydrogenase
(ADH) activity, while strengthening lipid metabolism and liver oxidation resistance, removes a large amount of freedom produced during alcohol metabolism
Base.
Compared with prior art, beneficial effects of the present invention are：Root of kudzu vine stem cell point is obtained by cultivating root of kudzu vine stem cell
Secrete the composition that effectively relieves the effect of alcohol that the factor can be extracted in the root of kudzu vine to greatest extent；And then significantly improve alcohol dehydrogenase in drunk person's body
(ADH)；It is quick to remove free radical；Clearing Sobering-up buccal tablet has no side effect safely simultaneously, eats and easy to carry.
Specific embodiment
To make those skilled in the art be better understood when technical scheme, with reference to embodiment pair
Technical solution of the present invention is described in detail.
Experimental technique used in following embodiments is conventional method unless otherwise specified.
Material used, reagent etc. in following embodiments, unless otherwise specified, commercially obtain.
Embodiment 1
A kind of clearing Sobering-up buccal tablet, including following portions by weight raw material, 6 parts of fructose, 1 part of menthol, 2 parts of citric acid,
2 parts of magnesium stearate, 60 parts of root of kudzu vine stem cell secretion factor.
Embodiment 2
A kind of clearing Sobering-up buccal tablet, including following portions by weight raw material, 7.5 parts of xylitol, 2.5 parts of menthol, lemon
3 parts of acid, 3.5 parts of magnesium stearate, 70 parts of root of kudzu vine stem cell secretion factor.
Embodiment 3
A kind of clearing Sobering-up buccal tablet, including following portions by weight raw material, 9 parts of maltitol, 4 parts of menthol, citric acid 4
Part, 5 parts of magnesium stearate, 80 parts of root of kudzu vine stem cell secretion factor.
Root of kudzu vine stem cell secretion factor described in above example 1-3 is to be prepared by the following method gained：Take newborn Pueraria lobota
Root, is cut with after the Bravo surface sterilizing of 0.5-0.8%；By the tissue containing forming layer, bast, cortex and epidermis gently
Peeled off from xylem on ground；The culture on solid-state isolation medium that is organized in that will be obtained, 18-22 DEG C of cultivation temperature cultivates 28-30d
Newborn forming layer stem cell is separated with the callus of dedifferentiation afterwards, and the forming layer stem cell of acquisition is transferred into liquid growth
On culture medium, with 80-110rpm, 19-21d is cultivated at 18-22 DEG C；The cell line of acquisition continues to amplify culture 21- at 18-22 DEG C
23d, uninterruptedly stirs during culture；Cell line obtained by culture retains macromolecular mass through ultrafiltration, is cleaned by ultrasonic and crushes macromolecular
Rotation is emptied evaporation after group's cell line, and vacuum freeze drying obtains final product root of kudzu vine stem cell secretion factor.Wherein, the intensity of ultrasonic cleaning
No more than 50HZ, also not preferably less than 40HZ；Rotation is emptied evaporating temperature no more than 75 DEG C, also not preferably less than 70 DEG C.
The solid-state isolation medium for using is MS solid medium+6-BA0.8-1.2mg/L+2,4-D 0.8-1.2mg/L+
NAA0.1-0.3mg/L；
The liquid growth medium for using is MS liquid culture medium+6-BA0.8-1.2mg/L+2,4-D 0.1-0.3mg/L.
By the yield of Puerarin, daidzein in conventional method detection root of kudzu vine stem cell secretion factor, while with routine
Puerarin in powder obtained in the root of kudzu vine water extract that water extraction method is obtained, daidzein yield as a comparison, the results are shown in Table 1.
Puerarin in the root of kudzu vine stem cell secretion factor of table 1 and root of kudzu vine water extract, daidzein
Yield is compared
Composition Puerarin, the yield of daidzein of effectively being relieved the effect of alcohol in root of kudzu vine stem cell secretion factor as can be seen from Table 1 show
Write higher than the corresponding composition in root of kudzu vine water extract.
In order to assess a kind of dispelling effects of alcohol of clearing Sobering-up buccal tablet of the present invention, mouse 48 is taken, is randomly divided into 4 groups,
Every group 12, clearing Sobering-up buccal tablet group respectively of the present invention, commercially available Sobering-up buccal tablet group, model control group, blank control group.Mouse
After fasting 15h, in addition to blank control group gastric infusion physiological saline, the equal gavage 52%vol Red Star strong, colourless liquor distilled from sorghum of other each groups
0.03mL/g.In 30min before gavage 52%vol Red Star strong, colourless liquor distilled from sorghum, administration group is administered respectively, and dosage is：Clearing of the present invention is relieved the effect of alcohol
Lozenge group, the commercially available equal 2.500g/kg of Sobering-up buccal tablet group, the physiological saline of model control group gavage equivalent, blank control group gavage
Equivalent distilled water.2h puts to death each group mouse after drinking, takes liver.According to 1g livers: it is molten that the ratio of 4mL sucrose solutions measures sucrose
Liquid.Liver first uses normal saline flushing, after rinsed with sucrose solution, in placing into load weighted sucrose solution, in ice-water bath
In shred, shake up, homogenate is put into 10mL
In centrifuge tube, 12min is centrifuged with 5000r/min, to remove cell fragment, red blood cell and core, carefully taken out
Clear liquid, 10min is centrifuged with 9000r/min again, obtains supernatant for the measure of ADH vigor, and whole centrifugal process is maintained at 0~
Carried out at a temperature of 4 DEG C.
5 groups of mouse are won eyeball and take blood respectively at 5min, 15min, 30min, 45min, 60min, the 75min after timing,
Using ethanol mass concentration in gas chromatography measure whole blood；Liver and gastric tissue freezen protective are taken simultaneously, determine second in tissue
Alcohol dehydrogenase (ADH) enzyme activity, superoxide dismutase (SOD) enzyme activity, the results are shown in Table 2
The change (mg/100ml) of ethanol mass concentration in the mouse blood of table 2
As shown in Table 2, naive mice ethanol in blood content is maximum in 5min, and administration group reaches in 30min
To maximum, meanwhile, each time point ethanol in blood content of administration group is below blank group, and administration group can postpone ethanol and enter
Enter the speed of blood, while the ethanol for entering blood is reduced, and the clearing Sobering-up buccal tablet group of the embodiment of the present invention 2 is reduced and enters blood
The amount of the ethanol of liquid is significantly higher than commercially available Sobering-up buccal tablet group, illustrates that the clearing Sobering-up buccal tablet of embodiment 2 can significantly reduce stomach and intestine to second
The absorption of alcohol.
ADH activity in the mouse liver of table 3
| Group | Dosage (g/kg) | ADH vigor (U/0.1m l) |
| Blank control group | - | 851.541 |
| Model control group | - | 552.216 |
| The clearing Sobering-up buccal tablet group of embodiment 2 | 2.500 | 1220.302 |
| Commercially available Sobering-up buccal tablet group | 2.500 | 862.956 |
As shown in Table 3, compare with blank group, ADH activity is significantly raised in administration group Mouse Stomach, shows that Sobering-up buccal tablet can
Make ADH increased activities in stomach, and the clearing Sobering-up buccal tablet group of the embodiment of the present invention 2 makes the amplitude of ADH increased activities in stomach significantly big
In commercially available Sobering-up buccal tablet group, the result is consistent with ethanol in blood assay result, shows the clearing solution of the embodiment of the present invention 2
Wine lozenge, can significantly improve internal ADH activity, suppress absorption of the stomach and intestine to alcohol, reduce alcohol content in blood, from
And reduce detrimental effect of the alcohol to body.
SOD activity in the mouse liver of table 4
| Group | Dosage (g/kg) | SOD vigor (U/0.1m l) |
| Blank control group | - | 904.462 |
| Model control group | - | 574.121 |
| The clearing Sobering-up buccal tablet group of embodiment 2 | 2.500 | 885.159 |
| Commercially available Sobering-up buccal tablet group | 2.500 | 1320.132 |
A large amount of free radicals can be produced during alcohol metabolism, these free radicals can form radical reaction, ultimately caused dizzy
The symptom after drinking such as dizzy, headache, local skin allergy, digestive discomfort, SOD is the enzyme of the important removing free radical of human body, can from table 4
Know, compared with blank group, model group SOD activity is significantly reduced, because intermediate product is generated in alcohol metabolism can destroy
The metal-complexing in SOD activated centres, causes enzyme to be damaged, and causes enzyme activity to decline.Relative to model group, administration group can be notable
SOD activity in liver is improved, so as to quickly remove free radical, slows down radical reaction, mitigate ill symptomses after drinking, and take
SOD activity is significantly higher than and takes commercially available Sobering-up buccal tablet group mouse in the mouse liver of the clearing Sobering-up buccal tablet group of the embodiment of the present invention 2
SOD activity in liver.
Hereinafter, by taking the disclosed formula of embodiment 3 as an example, the specific preparation method for introducing clearing Sobering-up buccal tablet of the present invention should
Method comprises the steps：By 9 parts of maltitol, 4 parts of menthol, 4 parts of citric acid, 5 parts of magnesium stearate, root of kudzu vine stem cell secretion
80 parts of the factor, smashes mixing, granulation, and compressing tablet is that clearing obtains Sobering-up buccal tablet.
Obviously, above-described embodiment is only section Example of the invention, rather than whole embodiments.Opened based on of the invention
Show, the resulting all other implementation method on the premise of creative work is not made of those of ordinary skill in the art, all
Belong to the scope that present aspect is protected.
Claims (9)
1. a kind of raw material of clearing Sobering-up buccal tablet, including following portions by weight：Sweetener 6-9 parts, menthol 1-4 parts, citric acid
2-4 parts, magnesium stearate 2-5 parts, it is characterised in that also including 60-80 parts of root of kudzu vine stem cell secretion factor.
2. clearing Sobering-up buccal tablet according to claim 1, it is characterised in that the sweetener is sucrose free sweetener.
3. clearing Sobering-up buccal tablet according to claim 2, it is characterised in that the sucrose free sweetener is fructose, sweet
One kind in sweet element, xylitol and maltitol.
4. the clearing Sobering-up buccal tablet according to claim any one of 1-3, it is characterised in that the root of kudzu vine stem cell secretion factor
It is to be prepared by the following method gained：The newborn root of kudzu vine is taken, is cut with after the Bravo surface sterilizing of 0.5-0.8%；To contain
The tissue of forming layer, bast, cortex and epidermis is lightly peeled off from xylem；Solid-state isolation medium is organized in by what is obtained
Upper culture, 18-22 DEG C of cultivation temperature, newborn forming layer stem cell separates with the callus of dedifferentiation after culture 28-30d,
The forming layer stem cell of acquisition is transferred on liquid growth medium, with 80-110rpm, 19-21d is cultivated at 18-22 DEG C；Obtain
The cell line for obtaining continues to amplify culture 21-23d at 18-22 DEG C, is uninterruptedly stirred during culture；Cell line obtained by culture is through super
Filter retention macromolecular mass, is cleaned by ultrasonic rotation after crushing macromolecular mass cell line and is emptied evaporation, and vacuum freeze drying obtains final product the root of kudzu vine
Stem cell secretion factor.
5. clearing Sobering-up buccal tablet according to claim 4, it is characterised in that the solid-state isolation medium is MS solid state rheologies
Base+6-BA 0.8-1.2mg/L+2,4-D 0.8-1.2mg/L+NAA 0.1-0.3mg/L.
6. clearing Sobering-up buccal tablet according to claim 4, it is characterised in that the liquid growth medium is MS liquid cultures
Base+6-BA 0.8-1.2mg/L+2,4-D 0.1-0.3mg/L.
7. clearing Sobering-up buccal tablet according to claim 4, it is characterised in that the intensity of the ultrasonic cleaning is 40-50HZ.
8. clearing Sobering-up buccal tablet according to claim 4, it is characterised in that the rotation is emptied evaporating temperature for 70-75 DEG C.
9. the preparation method of clearing Sobering-up buccal tablet is according to claim any one of 1-8：By sweetener 6-9 parts, menthol
1-4 parts, citric acid 2-4 parts, magnesium stearate 2-5 parts, 60-80 parts of root of kudzu vine stem cell secretion factor smashes mixing, granulation, and compressing tablet is
Clearing obtains Sobering-up buccal tablet.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107751980A (en) * | 2017-09-05 | 2018-03-06 | 马鞍山市安康菌业有限公司 | A kind of preparation method of nourishment for vitality buccal tablet |
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| CN103305455A (en) * | 2013-06-05 | 2013-09-18 | 林树芳 | Taxus chinensis plant stem cell line breeding and anticancer drug extracting and preparing method |
| CN104195098A (en) * | 2014-09-22 | 2014-12-10 | 古焕庆 | Dendrobium officinale stem cell and isolated culture method thereof |
| CN104247947A (en) * | 2013-06-27 | 2014-12-31 | 南京乐呵呵庄园农业科技有限公司 | Lozenge capable of dispelling effects of alcohol and production method thereof |
| CN104473172A (en) * | 2014-12-31 | 2015-04-01 | 云南牟定三福工贸有限公司 | Kudzuvine root buccal tablet and preparation method thereof |
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| CN103305455A (en) * | 2013-06-05 | 2013-09-18 | 林树芳 | Taxus chinensis plant stem cell line breeding and anticancer drug extracting and preparing method |
| CN104247947A (en) * | 2013-06-27 | 2014-12-31 | 南京乐呵呵庄园农业科技有限公司 | Lozenge capable of dispelling effects of alcohol and production method thereof |
| CN104195098A (en) * | 2014-09-22 | 2014-12-10 | 古焕庆 | Dendrobium officinale stem cell and isolated culture method thereof |
| CN104473172A (en) * | 2014-12-31 | 2015-04-01 | 云南牟定三福工贸有限公司 | Kudzuvine root buccal tablet and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107751980A (en) * | 2017-09-05 | 2018-03-06 | 马鞍山市安康菌业有限公司 | A kind of preparation method of nourishment for vitality buccal tablet |
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