CN106668377A - Hui traditional Chinese medicine fiveleaf akebia fruit anti-esophageal cancer pill and preparation method thereof - Google Patents

Abstract

The invention relates to a formula and a preparation method of a Hui traditional Chinese medicine fiveleaf akebia fruit anti-esophageal cancer pill. According to the present invention, the Hui traditional Chinese medicine fiveleaf akebia fruit anti-esophageal cancer pill is a green high-tech Chinese herbal medicine for esophageal cancer treatment; fiveleaf akebia fruit, radix sophorae tonkinensis, cortex acanthopanacis, eucommia ulmoides and other Chinese herbs are mixed according to a certain ratio, water is added, and decoction, extraction, concentration and pelletizing are performed to obtain the traditional Chinese medicine pill; and the Hui traditional Chinese medicine fiveleaf akebia fruit anti-esophageal cancer pill mainly treats esophageal cancer, can further treat throat cancer, stomach cancer, large intestine cancer and other digestive system cancers, and has characteristics of moderate components and moderate doses, wherein the modern medical pharmacology experiment results prove that the selected medicines can treat cancers, and the body functions are fundamentally improved and the cell cancerization is prevented in the low cost manner so as to recover the health body.

Description

Hui ethnic group's Chinese medicine moon letter oesophagus anticancer bolus and preparation method thereof

Technical field

Hui ethnic group's Chinese medicine moon letter oesophagus anticancer bolus according to the present invention are a kind of green high-tech Chinese herbal medicines of the prevention and treatment cancer of the esophagus.The invention further relates to the preparation method of the medicine, belongs to traditional Chinese medicine class.

Background technology

According to《China's tumour registration annual report in 2014》Data display, according to China for each person 74 years old life-span calculate, Chinese all one's life suffer from malignant tumour probability be 22%, average minute clock has 6 people to be diagnosed as malignant tumour, and tumour has become a kind of common disease in China.At present the cancer patient of China is about ten thousand people more than 700, and every year with the speed of more than 100 ten thousand people in increase.And the whole world

According to statistics, in the cancer patient of China nearly 8,000,000, have 31.27% for Alimentary System patient, wherein patient with esophageal carcinoma accounts for the 29.7% of Alimentary System patient, almost half.

Cancer of the esophagusDisease locus are typically organized in epithelium of esophagus, and it is exactly swallowing and digestive function for patient that it directly affects, and health is slowly etched with regard to this.The pathogenic factor of cancer of the esophagus mainly has three, and one is malnutritive, though that is, now the living standard of people improves, due to the change of diet hobby and mode, will also result in malnutritive and trace element shortage；Two is that diet is lack of standardization, and in the grain and drinking-water of district occurred frequently, nitrate, nitrite and secondary amine content significantly increase, and these materials are easily-synthesized carcinogen nitrosamine in stomach；Three is esophageal injury and disease induction, and esophageal injury and some esophagel diseases are likely to become the inducement for causing cancer of the esophagus, and long-term chronic inflammation, ulcer, or chronic stimulation, and then esophageal epithelial proliferation are caused because of being detained in oesophagus, finally result in canceration.Although cancer of the esophagus does not possess infectiousness, the destruction to human body is but not allow to look down upon.

Though the early symptom of the cancer of the esophagus is more substantially, generally always flu etc is mistakenly considered by people, therefore often ignored, but do not know that the speed that cancer of the esophagus slowly deteriorates is very fast, once and feel increasingly apparent to be difficult to swallow, most likely deteriorated as cancer.Afterwards may be by operation to the process of cancerization Regional resection, to reduce the death rate of cancer of the esophagus.

At present treatment cancer of the esophagus the best way is operation, postoperative to be also performed to chemotherapy, and chemotherapy not only large side effects, patient suffering is difficult to stand, and success rate is also very low, the life cycle after most Chemotherapy in Patients was with regard to 1 year or so --- certainly this is also relevant with the over-treatment given birth to without skilful doctor.And on the other hand, although some perform the operation, held due to a variety of causes and can't stand chemotherapy,Can only palliative treatment, expect that miracle comes ...

The cancer of the esophagus is at present more refractory disease more as cancer of the stomach, all, but refractory representative cannot be controlled, and in addition to above-mentioned western medical treatment method, the traditional Chinese medical science also has many effectively treatment methods.The traditional Chinese medical science, according to the whole body feature diagnosis and treatment of patient, goes for various each phase cancer with organic conception.The advantage of Chinese medicine cancer is to be conducive to stablizing the state of an illness, and toxic and side effect is slight, symptom improves more apparent, slows down PD, tumor regression or the longer-term existence of band knurl, and patient is easy to receive and expense is than less expensive.At present doctor trained in Western medicine is also considered as traditional Chinese medicine can contribute to reducing the toxicity of Radiotherapy chemotherapy as the auxiliary treatment of cancer, improve cancer related symptoms, improve life quality, extend life cycle.But exist problem be the traditional Chinese medical science prescription uniformity it is poor, treatment mainly be experience.From in terms of existing proved recipe for cancer, folk prescription, always there is --- majority is more than more than half --- medicine to be all not prove " compatibility " medicine of function for cancer and effect " diagnosis and treatment based on an overall analysis of the illness and the patient's condition " by modern medicine pharmacological evaluation in selected Chinese herbal medicine medicinal material, inventors believe that very improper；And folk prescription, folk prescription cure the disease lean on be test, often stop over the time cured the disease.

The content of the invention

The purpose of the present invention, be aiming at Cancer in China patient assessment be difficult to and in the side's of curing the desease poor consistency, repeatable poor, high level evidence-based medicine EBM be theoretical and the relative shortage of evidence,Thus the situation for waiting deficiency by rule of thumb that is mainly for cancer, propose a kind of new dosage and preparation method, there is provided one kind reduces the incidence of disease of the cancer of the esophagus from the beginning of prevention, start to slow down its tempo from canceration, the green high-tech Chinese herbal medicine for inducing its atrophy apoptosis is started from tumour.Specifically, the present invention one is particularly suited for use in esophageal ulcer before treatment cancer in case its canceration, two is can to treat cancer just ulcer, in case it continues to deteriorate, three is inducible into the cancerous swelling atrophy apoptosis of knurl, with very low cost, fundamentally improve physical function, so as to get well.Its sharpest edges are to greatest extent to induce self apoptosis of cancer cell and differentiation, promote cancerous swelling progressively atrophy.In specific formula, also coordinate diagnosis and treatment based on an overall analysis of the illness and the patient's condition, induced because of esophageal injury, disease according to the origin cause of formation of cancer of the esophagus, dietary preferences nutrient imbalance causes immunologic hypofunction, cause normal cell to be compromised because of Helicobacter pylori infection, apoptosis, digestive tract ulcer, canceration " taking advantage of a weak point ", because " weakened body resistance poison poly- ", " empty in healthy tendency " and the characteristics of causes the basic pathology interpretation of the cause, onset and process of an illness such as metastases, utilization or strengthening vital QI to eliminate pathogenic factors, orTonification and purgation in combination, or regulating qi to disperse stagnation, or the strongly fragrant resolving sputum of solution, or it is clearing heat and detoxicating, or reinforcing and reducing methods and the method used, it is empty in healthy tendency to correct, poly- and internal organs imbalance of yin and yang function reduction the deficiency of the solidifying poison of heresy, adjust and improve the immunologic function of body, to reach the purpose of overall tumor suppression, so as to improve the overall curative effect and late result of carninomatosis treatment, a kind of green high-tech Chinese herbal medicine formula and compound method that function for cancer and effect are proved by modern medicine pharmacological evaluation is provided for esophageal cancer patients, with very low or relatively low cost, fundamentally improve physical function, the deterioration of symptom management simultaneously makes the state of an illness gradually take a turn for the better, finally recover healthy.Thus also to patient one select different treatment methods or several method to share particularly traditional Chinese and western medicine to combine the leeway of complex treatment application to consider according to the personal state of an illness, economic situation, personal inclination, to obtaining optimum curative effect, survival rate is easily improved --- particularly more than 5 years survival rates.

Technical scheme proposed by the invention is：

First, Hui ethnic group's Chinese medicine moon letter oesophagus anticancer bolus of the described prevention and treatment cancer of the esophagus and preparation method thereof, are by made by following weight proportion raw material：

Fiveleaf akebia fruit 25g, red sage root 9g, subprostrate sophora 25g, rhizoma arisaematis 5g,

Cortex acanthopanacis 9g, bark of eucommia 9g, seed of Chinese dodder 9g, mushroom 15g,

Fruit of Chinese wolfberry 15g, bighead atractylodes rhizome 9g, tomato 50g

This side is substantially square for one decoction on the one.In practical application, also the 1-3 taste traditional Chinese medical science " harmony between man and nature, dialectical treatmert " theory can be increased according to the physique of patient and conditions“Dialectical compatibility " medicine.

In view of with this, basic side's decoction decoction of medicinal ingredients amount is big, taste is not good enough, patient is difficult to drink, therefore must be prepared using special process.

2nd, it is by the preparation method that above-mentioned each raw material makes medicine pill of the present invention：

A, extract preparation

（1）, extract

A, for the first time extraction：By the weight of said herbal medicine in addition to the red sage root, the bark of eucommia, tomato, all amplify 10 times, after clean water, it is placed in BT-2 stainless steels to extract in kettle, plus after 7-9 times of running water, is heated to 100 DEG C of constant temperature and extracts 1 hour or so, extraction fluid, pressure filtration, filtrate is standby.

B, second extraction：Add in kettle the 5-7 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract or so half an hour, extraction fluid, pressure filtration, filtrate is standby.

C, third time are extracted：Add in kettle the 3-5 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes or so, extraction fluid, pressure filtration, filtrate is standby.

（2）, concentration

The extract of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), be heated to 80 DEG C, be concentrated into relative density 1.10～1.20, it is standby.

（3）, powder processed

Red sage root 9g, bark of eucommia 9g are amplified into 10 times, it is end together to crush, cross 100 mesh sieves, it is standby.

（4）, dispensing

In 300,000 grades of dust proof workshops, above-mentioned medicinal powder is put in mixer together with aforementioned concentrate and is sufficiently mixed, stir.

(5) drying, crushing

The spice being well mixed is placed in into 60-70 DEG C of baking 4-5 hour in baking oven, is then crushed, cross 100 mesh sieves.

(6) granulate

The spice being well mixed is inserted in comminutor and is granulated.

(7) whole grain

The particle for making is carried out into whole grain, 35 mesh sieves are crossed.

(8) it is dried

Whole good particle is inserted in heat circulation drying oven, aeration-drying is to moisture ＜ 8% at 80 DEG C.

(9) pill

Dry mixed gained medicine is put into pill in Chinese medicinal pills preparing machine, pill is optimal with below 4mm.

B, packaging

First the pill for making is fitted into vinyon pouch, every bag of 8g, then the pouch mounted box for installing, vanning, sterilizing (are adopted into 60Co irradiation, irradiation dose is 8kGy）.

, warehouse-in

Irradiated finished product is put in storage by the principle of first in first out.

Routine instructions of taking of the invention：Three times a day, every time 1 bag, on an empty stomach (taking half an hour after can not drink water in a large number, in order to avoid water down liquid).The pungent grade food larger to gastrointestinal irritation is not eaten during medication.

This medicine does medicine efficacy enhancing ingredient and takes better with pan-fried tomato soup.The specific practice of pan-fried tomato soup is：Take from so well-done little tomato（50 grams or so）Chopping, puts 10 grams or so vegetable oil in pot, heat, and is put into appropriate chopped spring onion, salt, pours into be decocted in pot by the tomato of chopping when chopped spring onion blows out fragrance and fries 1-2 minutes, then infuses to be got away into suitable quantity of water and take the dish out of the pot.

The effect of each raw material of the present invention：

Fiveleaf akebia fruit,ForLardizabalaceaePlantAkebi threeleaf akebiaOrAkebia trifoliata varaustralisDry mature fruit.It is sweet, cold in nature, function isDispersing stagnated hepatoqi, promoting blood circulation and stopping pain, relieving restlessness diuresis.Cure mainlyStomachache due to emotional depression and the hyperactive liver-qi attacking the stomach、Stomach energyFood is slow-witted, polydipsia,Dysentery、Pain in the back、Hypochondriac pain, hernia etc..The less single of fiveleaf akebia fruit is used for kinds of tumors with his medicine phases 5 more with controlling in tumour, and has preferable curative effect more.

The red sage root,Bitter, micro-pungent, cold nature；The heart, spleen, liver, the medicine of kidney blood system.It is the root and rhizome of the Labiatae herbaceous plant red sage root.With promoting blood circulation and removing blood stasis, nourishing blood and tranquilization, effect of cool blood detumescence.The red sage root cures mainly hemostasis head, chest, the side of body, abdomen pain containing tanshinone, protocatechualdehyde, protocatechuic acid, danshensu, vitamin E etc., gathers, irregular menstruation,DysmenorrhoeaAmenorrhea, postpartum stasis of blood, joint pain, beat the stasis of blood swell, warm disease is vexed, palpitation due to deficiency of blood, sore swollen toxin, red rash mange.

Subprostrate sophora,ForLegume root of subprostrate sophoraRoot.Bitter cold in nature.Effect is to relieve inflammation or internal heat, detoxifying, subsiding a swelling, pain relieving.Cure mainly：Laryngalgia, sore-throat,Larynx numbness,Swelling and aching of gum,Breathe heavily fullHeat is coughed,Jaundice, diarrhea, heat is swollen,Mange, snakeworm dog bite.Its is rightThe cancer of the esophagus、Nasopharyngeal carcinoma, cervical carcinoma,Carcinoma of urinary bladder, leukaemia have inhibitory action.Composition pharmacology：Containing TA about 0.93%, whereinMatrine(Matrine) 0.52%,Oxymatrine(Oxymatrine) 0.35%, Yi JihanD-maackianin-β-D-glucoside(Sophoraponicin)、Red sandalwoodPlain (Pterorepine),Screw oil expeller axleGrass roots glucoside (TrifolirhiZin),Albizzia kalkoraPlain (Maackian), sophoradin (Sophra) etc..DNA and RNA synthesis of the subprostrate sophora to tumour cell has obvious inhibitory action, so as to block the propagation of tumour cell, lymphocyte transformation can be promoted, excite or strengthen the CDCC of lymphocyte, T cell ratio is improved, strengthens or adjust macrophage phagocytic function, moreover it is possible to adjust endocrine, strengthen adrenocortical function, thus affect the occurrence and development of tumour.

Rhizoma arisaematis,Nature and flavorEffect：It is bitter, pungent, it is warm in nature, it is poisonous.It is eliminating dampness and eliminating phlegm, eliminating the phlegm arresting convulsion, dispersing swelling and dissipating binds.It is clinicalUsing：Suitable for kinds of tumors, such as tumor in digestive tract, intracranial tumour, brain metastasis, or tumor lympha is carried down shifting, sonCervical carcinoma、Oral cavityTumour,NerveSystem tumor.Additionally it is applied to heap soil or fertilizer over and around the roots of apoplexy phlegm, facial paralysis, hemiplegia, insane chronic, infantile convulsion, lockjaw, anemophlegmatic vertigo, larynx numbness, scrofula tuberculosis, carbuncle swells, traumatic injury, snake bite and insect sting etc..

Cortex acanthopanacis,Meridian distribution of property and flavor：Pungent, hardship, temperature.People's liver and kidney channel.Effect：Wines used as antirheumatic, strengthens the bone, blood circulation and promoting silt.Control wind-cold-dampness arthralgia, muscles and bones contraction urgency, pain in the back, impotence, flaccidity of lower limbs, children's retardation of walking, oedema, tinea pedis, sore subcutaneous ulcer pyogenic infections, bruise internal lesion caused by overexertion.Effect：This product is warm in nature, the warm promoting blood circulation of energy, there is the work(of promoting blood circulation, for exogenous injury or traumatic injury, there is the stagnant effect of promoting blood circulation, logical solidifyingization, has tonic effect again, to promote early healing.Bushen Yizhi; anti-inflammatory; calm, analgesia, it is antifatigue, strengthen macrophage inducement interferon; T cell, NK cells, K cells, the effect of macrophage killing tumor cell can be strengthened; increasing leukocyte, can be obviously promoted the formation of myeloid lineage progenitor population, there is significantly protection and leucocyte rising effect to the bone marrow suppression that chemotherapy radiotherapy causes; removing toxic substances, also with antitumor action.Salvia chinensis,For the herb of Labiatae annual herb plant salvia chinensis, flavor efficacy：It is bitter, mild-natured.It is clearing heat and detoxicating, cool blood flat liver, inducing diuresis for removing edema, dissipating bind.Clinical practice：It is usually used in treating the cancer of the esophagus, carcinoma of parotid gland, liver cancer, cancer of the stomach, cardia cancer etc..Medical science religion ' educate net compile additionally, be additionally operable to treat virus hepatitis, hot summer weather rush down dysentery, infantile acute nephritis, oedema, rheumatic arthritis, chyluria, treating swelling and pain by traumatic injury, venomous snake bite, boil swell and ache, metrorrhagia etc..

The bark of eucommia,It is Chinese famous and precious tonic herb for the dry bark of the Eucommiaceae plant bark of eucommia.Nature and flavor：It is sweet；Micro-pungent；It is warm in nature.Return through：Liver Channel；Kidney channel.Effect：Filling liver kidney；Strengthening the bones and muscles；Antiabortive gas.The bark of eucommia has filling liver kidney, and internal rubbish are removed in strengthening the bones and muscles, strengthen human body cell metabolism, prevent muscle skeleton aging, balanced human's blood pressure, decomposer inner cholesterol, body fat is reduced, recovers blood vessel elasticity, diuresis heat-clearing, broad-spectrum antiseptic, stimulating central nervous system, improves white blood cell count, strengthens the remarkable efficacies such as body immunity.Cure mainly：Spinal column ache；Impotence；Frequent micturition；Dribbling urination；Arthralgia due to wind-dampness；Fetal irritability；Habitual abortion.It is applied to：1st, the unconsolidation of the kidney-qi：Card is shown in frequent micturition or dripping urination, uncontrolled urination, impotence, weak pregnant woman, fetal irritability or waist pendant pain etc..It is more common in chronic prostate disease, sex dysfunction, sterility, threatened abortion or habitual abortion etc..2nd, caused by liver and kidney deficiency：Card is shown in that dizziness, soreness of waist and knee joint, muscles and bones impotence are weak etc..It is more common in high blood pressure, vertigo, cerebrovascular accident sequelae, chronic renal disease, polio etc..3rd, there is caused by liver and kidney deficiency sign person for diseases such as chronic joint diseases, bone tuberculosis, dysmenorrhoea, dysfunctional uterine bleeding, chronic pelvic inflammatory diseases.

The seed of Chinese dodder,It is warm in nature；It is sweet；Return liver, spleen, kidney channel.Effect and nourishing liver and kidney, antiabortive, the improving eyesight of effect, antidiarrheal.For：Impotence and seminal emission, dripping urination, enuresis frequent micturition, medicine knees soreness, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, fetal irritability, spleen kidney deficiency is rushed down；Externally treating leucoderma, the ability with certain inhibition cancer cell can reduce the incidence of canceration.

Mushroom,Nature and flavor are sweet, put down, nontoxic.Return liver；Stomach.Indication;Righting qi-restoratives；Spleen benefiting and stimulating the appetite；Wind-dispelling promoting eruption；Phlegm-eliminiating and qi-regulating；Removing toxic substances；Anticancer.Main healthy tendency is weak；God is tired weak；It is indigestion and loss of appetite；Indigestion；Anaemia；Rickets；Hypertension；Hyperlipidemia；Chronic hepatitis；Night sweat；Urinary incontinence；Oedema；Measles without adequate eruption；Nettle rash；Malicious mushroom poisoning；Tumour；Beneficial gas are not hungry, control wind blood-breaking, and beneficial taste helps food, the rickets suffered from Jing after the obstacle that often to eat use can prevent the serium inorganic phosphorus that human body causes due to a lack of vitamin D and blood calcium metabolism, the inflammation of the various mucous membranes of prevention human body and skin, prevention physical decline, capillary rupture, gum and abdominal cavity hemorrhage etc..Pharmacological action：1. immunity of organism is adjusted, 2. antitumor action：Lentinan double stranded RNA has suppressing cell reproduction and antitumaous effect, and lentinan can promote antibody to be formed, activated macrophage, reduces the incidence of methyl cholanthrene induced tumor.To strong mutagens, her methylmesylate directly prevents DNA replication dna from having very strong inhibitory action to lentinan, so as to have antimutagenic activity.3. antivirus action：Sulphation lentinan can inhibiting HIV and human T-leukemia virus's I types.The double stranded RNA extracted from mushroom has antivirus action.4. antihepatitic activity：Lentinan plays the role of anti-chronic hepatitis, and T cell subgroup hypofunction and IL-2 expression of receptor deficiencies are the major reasons that chronic hepatitis patient can not remove infection.Also have been reported that lentinan is secreted to human lymphocyte IL-2 and IL-2 expression of receptor has dual regulation.5. the effect of pair platelet aggregation, 6. antioxidation：The water extract of mushroom has scavenging action to hydrogen peroxide (H2O2).

The fruit of Chinese wolfberry,Matrimony vine is mild-natured, sweet, has functions that tonifying kidney and benefiting sperm, nourishing yin and supplementing blood, nourishes the liver to improve visual acuity, moistens the lung and relieve the cough, and matrimony vine is all contained in the medicine of many health cares.Matrimony vine contains amino acid, alkaloid, glycine betaine, wintercherry red pigment and multivitamin, also containing various linoleic acid.The effect of the fruit of Chinese wolfberry is with effect：1st, body's immunity is improved, strengthens organism adaptation regulating power, the edible fruit of Chinese wolfberry can strengthen the body resistance to consolidate the constitution and the timid heresy of righting, not only strengthen body function, promotion Health restoration, and the resistance against diseases of body can be improved, resist the infringement of disease and evil.Strengthen adaptability of the body to various destructive stimuluses.2nd, with antitumaous effect, the fruit of Chinese wolfberry is to the generation of cancer cell and is diffused with obvious inhibitory action, and the result of present age experiment and clinical practice shows that folium lycii is often drunk for tea, can significantly improve and improve old man, valetudinarian andTumourThe immunologic function and physiological function of patient, the effect with strong human body and anti-aging.To cancer patient's combined with chemotherapy, there is mitigation toxic and side effect, prevent white blood cell from reducing, adjust the curative effects such as immunologic function.Experimental study finds：The trace element germanium contained in matrimony vine piece plays the role of obvious inhibition cancer cell, is completely severed can cancer cell, and inhibiting rate is up to 100%.3rd, with significant function of improving eyesight, the fruit of Chinese wolfberry is particularly good at improving eyesight, so being also commonly called as " bright eye ".Blurring of vision and yctalopia that ancient Chinese medicine doctor treatment deficiency of liver-blood, deficiency of kidney-YIN cause, are frequently used the fruit of Chinese wolfberry.Famous prescription QIJU DIHUANG WAN, just with the fruit of Chinese wolfberry as key agents.Among the people also to commonly use fruit of Chinese wolfberry treatment chronic ocular disease, it is exactly simple and effective dietotherapy side that matrimony vine steams egg.4th, with antifatigue effect, the fruit of Chinese wolfberry can dramatically increase the stockage of muscle glycogen, hepatic glycogen, improve human activity, play the role of antifatigue.5th, the hematopoiesis function of human body can be strengthened, the fruit of Chinese wolfberry is obviously promoted hematopoietic cell proliferation, Cervical mucus can be made, strengthen the hematopoiesis function of human body.Except, the fruit of Chinese wolfberry contains the polyphenoils such as abundant LBP-X, beta carotene, vitamin E, selenium and flavonoids, there is preferable antioxidation.The fruit of Chinese wolfberry can mitigate free radical peroxide injury to Green Tea Extract peroxidating, so as to contribute to anti-aging, extend the life-span.

The bighead atractylodes rhizome,The bighead atractylodes rhizome for air making-up and spleen enlivening key medicine, for controlling syndrome of deficiency of spleen qi and stomach qi, splenasthenic diarrhea, indigestion, gastrointestinal tract disease, for controlling and middle tonifying spleen, dehumidify beneficial gas, in being assigned in tonic side, fills blood.The bighead atractylodes rhizome both can air making-up and spleen enlivening, again can eliminate dampness and have diuretic effect, therefore to control the good medicine of phlegm and retained fluid oedema, for controlling various oedema (such as renal, gestational, trophoedema).Bighead atractylodes rhizome beneficial gas tonifying spleen, has strengthening exterior and reducing sweat to act on, for controlling exterior deficiency spontaneous perspiration, arthritis rheumatalgia.Bighead atractylodes rhizome air making-up and spleen enlivening, and have antiabortive effect, for controlling fetal irritability.The effect of the bighead atractylodes rhizome mainly have calmness, blood vessel dilatation, anticoagulant, anti-gastric-ulcer, hepatic cholagogic, diuresis, it is strong, improve immune, anti-oxidant, antibacterial and antitumor etc..Bighead atractylodes rhizome invigorating the spleen to dry is good, the multiplex life of eliminate dampness and have diuretic effect.Bighead atractylodes rhizome sweetness and bitterness temperature is nontoxic, and strengthening exterior and reducing sweat disappears five cereals.Fetal irritability controls phlegm wet, and splenasthenic diarrhea all can take.

Tomato,Tomato has fat-reducing Weight reducing , dispelling fatigue, improve a poor appetite, improve the digestion to protein, reduce gasteremphraxis dyspepsia the effects such as.In recent years, in the anti-cancer or health food that numerous worldwide organizations are recommended, tomato always ranks among the best.Find in substantial amounts of epidemiological survey and zoopery, outstanding representation of the tomato in cancer-resisting is mostly derived from lycopene therein.So, lycopene be how to give protection against cancer, the first of anticancer, by a series of biochemical action, lycopene can promote Carcinoma cell differentiation (to good direction conversion), inhibition cancer cell propagation.Second, immune function of human body can be strengthened.Lycopene can promote some to have the cytokine secretion of anti-cancer, antitumaous effect, such as interleukins-II, dissolution of the activated lymphocyte to cancer cell；The lymphocyte being activated can discharge cytokine such as TNF etc. again, have lethal effect to tumour cell.3rd, lycopene has stronger It is anti-oxidant Effect.The aging of cell, damage are all relevant with Free Radical with canceration, and antioxidant (such as lycopene) is effectively removing free radical, so as to play whole body health-care effect, wherein be just included in protective effect on cancer risk playing an important role.

The effect of the present invention：

Cure mainly：The cancer of the esophagus, particularly the early stage cancer of the esophagus, with very low cost, fundamentally improve physical function, and control tumour continues to overgrow and makes it that final disappearance is gradually reduced, so as to recover healthy.

It is simultaneous to control：The cancer in digestive system such as throat cancer, cardiac cancer, pylorus cancer, cancer of the stomach, colorectal cancer.

Our the characteristics of is：

1st, flavour of a drug are more, and dosage is moderate, do not waste.

2nd, selected flavour of a drug are all to be proved that for cancer the cancer of the esophagus particularly can be treated by modern medicine pharmacological evaluation.And then always have in existing proved recipe for cancer, folk prescription --- even more than medicine more than half be all not by modern medicine pharmacological evaluation proved function for cancer and effect.Really it is that the traditional Chinese medical science is seen a doctor by rule of thumb, folk prescription is cured the disease by risk！

3rd, for focus, arrow arrow punching, i.e., selected flavour of a drug all especially grow tender of and hit the bull's eye, and As the medicine took effect, the symptoms lessened.As long as rather than it is for cancer, just jump on the bandwagon, be as a result that " dragon " does not harness the river on the contrary more.

4th, as much as possible " neutralisation ", i.e., selected flavour of a drug generally keep " neutrality ", do not tremble with fear not dry, not hot not cool.Patient can be thus set to suffer less within the cycle of whole medication, pull the devil by the tail less.And if really there is the situation of " getting angry " or " under let out ", then can be directed to concrete individual concrete condition completely, a bit " stopping leak ", the medicine of " fall fire " are specifically solved for interim addition.Rather than imagine at the very start patient may on tell or drop, and some unnecessary medicines are added to prescription, patient is all taken always during very long very long medication, ultimately cause adverse consequences.

Specific embodiment：Fiveleaf akebia fruit 25g, subprostrate sophora 25g rhizoma arisaematis 5g, cortex acanthopanacis, seed of Chinese dodder 9g, mushroom 15g, fruit of Chinese wolfberry 15g, bighead atractylodes rhizome 9g are respectively amplified into 10 times, after clean water, it is placed in BT-2 stainless steels to extract in kettle, plus after 7-9 times of running water, it is heated to 100 DEG C of constant temperature to extract 1 hour or so, extraction fluid, pressure filtration, filtrate is standby.Extract for second：Add in kettle the 5-7 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract or so half an hour, extraction fluid, pressure filtration, filtrate is standby.Third time is extracted：Add in kettle the 3-5 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes or so, extraction fluid, pressure filtration, filtrate is standby.Concentration：The extract of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), be heated to 80 DEG C, be concentrated into relative density 1.10～1.20, it is standby.Powder processed：Red sage root 9g, bark of eucommia 9g are respectively amplified into 10 times, it is end together to crush, cross 100 mesh sieves, it is standby.Dispensing：In 300,000 grades of dust proof workshops, above-mentioned medicinal powder is put in mixer together with aforementioned concentrate and 30g honey and is sufficiently mixed, stir.Drying, crushing：The spice being well mixed is placed in into 60-70 DEG C of baking 4-5 hour in baking oven, is then crushed, cross 100 mesh sieves.Granulation：The spice being well mixed is inserted in comminutor and is granulated.Whole grain：The particle for making is carried out into whole grain, 35 mesh sieves are crossed.It is dried：Whole good particle is inserted in heat circulation drying oven, aeration-drying is to moisture ＜ 8% at 80 DEG C.Pill：Dry mixed gained medicine is put into pill in Chinese medicinal pills preparing machine, pill is optimal with below 4mm.Packaging：First the pill for making is fitted into vinyon pouch, every bag of 8g, then the pouch mounted box for installing, vanning, sterilizing (are adopted into 60Co irradiation, irradiation dose is 8kGy）.Finally, irradiated finished product is put in storage by the principle of first in first out.

Claims (2)

1. Hui ethnic group's Chinese medicine moon letter oesophagus anticancer bolus and preparation method thereof, it is characterised in that it is by made by the raw material of following weight proportion：

Fiveleaf akebia fruit 25g, red sage root 9g, subprostrate sophora 25g, rhizoma arisaematis 5g,

Cortex acanthopanacis 9g, bark of eucommia 9g, seed of Chinese dodder 9g, mushroom 15g,

Fruit of Chinese wolfberry 15g, bighead atractylodes rhizome 9g, tomato 50g

This side is the substantially square of one decoction on the one, in practical application, can also increase the 1-3 taste traditional Chinese medical science " harmony between man and nature, dialectical treatmert " theory according to the physique of patient and conditions“Dialectical compatibility " medicine.

2. the weight proportion of the Hui ethnic group's Chinese medicine moon letter oesophagus anticancer bolus according to claim 1, it is characterised in that including following preparation processes：

A, extract preparation

（1）, extract

A, for the first time extraction：By the weight of said herbal medicine in addition to the red sage root, the bark of eucommia, tomato, all amplify 10 times, after clean water, it is placed in BT-2 stainless steels to extract in kettle, plus after 7-9 times of running water, is heated to 100 DEG C of constant temperature and extracts 1 hour or so, extraction fluid, pressure filtration, filtrate is standby；

B, second extraction：Add in kettle the 5-7 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract or so half an hour, extraction fluid, pressure filtration, filtrate is standby；

C, third time are extracted：Add in kettle the 3-5 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes or so, extraction fluid, pressure filtration, filtrate is standby；

（2）, concentration

The extract of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), be heated to 80 DEG C, be concentrated into relative density 1.10～1.20, it is standby；

（3）, powder processed

Red sage root 9g, bark of eucommia 9g are amplified into 10 times, it is end together to crush, cross 100 mesh sieves, it is standby；

（4）, dispensing

In 300,000 grades of dust proof workshops, above-mentioned medicinal powder is put in mixer together with aforementioned concentrate and is sufficiently mixed, stir；

(5) drying, crushing

The spice being well mixed is placed in into 60-70 DEG C of baking 4-5 hour in baking oven, is then crushed, cross 100 mesh sieves；

(6) granulate

The spice being well mixed is inserted in comminutor and is granulated；

(7) whole grain

The particle for making is carried out into whole grain, 35 mesh sieves are crossed；

(8) it is dried

Whole good particle is inserted in heat circulation drying oven, aeration-drying is to moisture ＜ 8% at 80 DEG C；

(9) pill

Dry mixed gained medicine is put into pill in Chinese medicinal pills preparing machine, pill is optimal with below 4mm；

B, packaging

First the pill for making is fitted into vinyon pouch, every bag of 8g, then the pouch mounted box for installing, vanning, sterilizing (are adopted into 60Co irradiation, irradiation dose is 8kGy）；

C, warehouse-in

Irradiated finished product is put in storage by the principle of first in first out.