CN106668721A - Hui-nationality Chinese herbal Chinaroot Greenbier Rhizome esophagus cancer inhibiting tablet and preparation method thereof - Google Patents

Abstract

The invention discloses a formula of a Hui-nationality Chinese herbal Chinaroot Greenbier Rhizome esophagus cancer inhibiting tablet and a preparation method thereof. The medicine is a green high-tech Chinese herbal medicine for treating esophagus cancer. The preparation method comprises the following steps: mixing Chinese herbal medicines such as Chinaroot Greenbier Rhizome, rhizoma curcumae, Stephania tetrandra, salammonite, etc. according to a certain ratio, adding water and decocting, extracting, concentrating and tabletting to obtain a traditional Chinese medicine tablet, which is used for mainly treating esophagus cancer as well as treating digestive cancers such as pharyngolaryngeal cancer, gastric cancer, colorectal cancer, etc. The invention has the characteristics of moderate medicinal odour and dosage. The selected medicines are proved through pharmacology experiments of modern medicine to be capable of treating cancers. The medicine can fundamentally improve body functions at low cost and prevent cell cancerization so as to recover body health.

Description

Hui ethnic group's Chinese medicine thorn Siberian cocklebur esophaguses hold back cancer piece and preparation method thereof

Technical field

It is a kind of green high-tech of the prevention and treatment esophageal carcinoma that Hui ethnic group's Chinese medicine thorn Siberian cocklebur esophaguses according to the present invention hold back cancer piece Chinese herbal medicine.The invention further relates to the preparation method of the medicine, belongs to Chinese medicine class.

Background technology

According to《China's tumour registration annual report in 2014》Data display, according to China's Life Calculation of 74 years old for each person, China The probability that people suffers from malignant tumor in all one's life is 22%, and average minute clock has 6 people to be diagnosed as malignant tumor, tumor China into For a kind of common disease.At present the cancer patient of China is about ten thousand people more than 700, and every year with the speed of more than 100 ten thousand people in increase. And the whole world

According to statistics, in the cancer patient of China nearly 8,000,000, have 31.27% for digestive system cancer patient, wherein patient with esophageal carcinoma Account for the 29.7% of digestive system cancer patient, almost half.

Esophageal carcinoma disease locus typically organize in epithelium of esophagus, its directly impact be exactly that patient swallows and digest work( Can, health is slowly etched with regard to this.The pathogenic factor of esophageal carcinoma mainly has three, and one is malnutrition, though i.e. people now Living standard improve, but due to the change of diet hobby and mode, will also result in lacking for malnutrition and trace element It is weary；Two is that diet is lack of standardization, and in the grain and drinking-water of district occurred frequently, nitrate, nitrite and secondary amine content significantly increase, These materials are easily-synthesized carcinogen nitrosamine in gastric；Three be esophageal injury and disease induction, esophageal injury and some food Pipe disease is likely to become the inducement for causing esophageal carcinoma, is detained and cause long-term chronic inflammatory disease, ulcer because of in esophaguses, or slowly Sexual stimuluses, and then esophageal epithelial proliferation, finally result in canceration.Although esophageal carcinoma does not possess infectiousness, the destruction to human body But it is not allow to look down upon.

Though the early symptom of the esophageal carcinoma is more substantially, usual to be always mistakenly considered flu etc by people, therefore is often neglected Depending on, but do not know that the speed that esophageal carcinoma slowly deteriorates is very fast, once and feel increasingly apparent to be difficult to swallow, most likely Deteriorate as cancer.Afterwards may be by operation to the process of cancerization Regional resection, to reduce the mortality rate of esophageal carcinoma.

At present treatment esophageal carcinoma the best way is operation, postoperative to be also performed to chemotherapy, and chemotherapy not only large side effects, suffer from Person's pain is difficult to stand, and success rate is also very low, and the life cycle after most Chemotherapy in Patients was with regard to 1 year or so --- certainly This is also relevant with the over-treatment given birth to without skilful doctor.And on the other hand, although some perform the operation, due to a variety of causes Hold and can't stand chemotherapy, can only palliative treatment, expect that miracle comes ...

The esophageal carcinoma is disease at present compared with refractory more as gastric cancer, all, but refractory is not represented and cannot controlled, except above-mentioned doctor trained in Western medicine Outside Therapeutic Method, the traditional Chinese medical science also has many effectively Therapeutic Method.The traditional Chinese medical science is with organic conception according to the dialectical opinion of whole body feature of patient Control, go for various each phase cancer.The advantage of Chinese medicine cancer is to be conducive to stablizing the state of an illness, and toxic and side effects are light Micro-, symptom improves more apparent, slows down PD, tumor regression or the longer-term existence of band tumor, and patient is easy to receive and expense Than less expensive.At present doctor trained in Western medicine is also considered as Chinese medicine can contribute to reducing the toxicity of Radiotherapy chemotherapy as the auxiliary treatment of cancer, Improve cancer related symptoms, improve life quality, extend life cycle.But the problem for existing is that the prescription uniformity of the traditional Chinese medical science is poor, Treatment mainly be experience.From in terms of existing proved recipe for cancer, folk prescription, always have in selected Chinese herbal medicine medical material --- it is most It is more than more than half --- medicine is all not proved function for cancer and acted on by modern medicine pharmacological evaluation " to distinguish Card treat " " compatibility " medicine, inventors believe that very improper；And folk prescription, folk prescription cure the disease lean on be test, often delay control The time of disease.

The content of the invention

The purpose of the present invention, be aiming at Cancer in China patient assessment be difficult to and in the side's of curing the desease poor consistency, repeatability Poor, high level evidence-based medicine EBM is theoretical and evidence is relative lacks, thus the situation for mainly waiting deficiency by rule of thumb for cancer, proposition one The new dosage of kind and preparation method, there is provided one kind reduces the sickness rate of the esophageal carcinoma from the beginning of prevention, starts to subtract from canceration Delay its tempo, the green high-tech Chinese herbal medicine for inducing its atrophy apoptosis is started from tumor.Specifically, the present invention one is special Shi Yongyu esophageal ulcer before cancer not treated in case its canceration, two is can to treat cancer just ulcer, in case it continues to deteriorate, three It is inducible into the cancerous protuberance atrophy apoptosis of tumor, with very low cost, fundamentally improves physical function, so as to recover strong Health.Its sharpest edges are to greatest extent to induce self apoptosis of cancerous cell and differentiation, promote cancerous protuberance progressively atrophy.In tool In the formula of body, also coordinate determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, induced because of esophageal injury, disease according to the origin cause of formation of esophageal carcinoma, dietary preferences nutrition is lost Weighing apparatus causes immunologic hypofunction, causes normal cell to be compromised because of Helicobacter pylori infection, apoptosis, and digestive tract ulcer, canceration " are taken advantage of It is empty and enter ", because " weakened body resistance poison gathers ", " healthy energy interior-deficiency " and the characteristics of cause the basic pathology pathogenesis such as neoplasm metastasis, with or righting dispel Heresy, orReinforcement and elimination in combination, or regulating qi to disperse stagnation, or resolving depression resolving sputum, or heat-clearing and toxic substances removing, or reinforcing and reducing and the method used, with correct healthy energy interior-deficiency, Poly- and internal organs imbalance of YIN and YANG function reduction the deficiency of the solidifying poison of heresy, adjusts and improves the immunologic function of body, to reach overall tumor suppression Purpose, so as to improve the overall curative effect and late result of carninomatosis treatment, provides for esophageal cancer patients and a kind of is cured by modern Learn green high-tech Chinese herbal medicine formula and compound method that pharmacological evaluation proves function for cancer and effect, with very low or Relatively low cost, fundamentally improves physical function, and the deterioration of symptom management simultaneously makes the state of an illness gradually take a turn for the better, and the final body that recovers is good for Health.Thus also to patient one according to the personal state of an illness, economic situation, personal inclination come consider select different treatment methods or Several method shares particularly Chinese and western medicine and combines the leeway of Comprehensive Treatment application, to obtaining optimum curative effect, easily improves life Deposit rate --- particularly more than 5 years survival rates.

Technical scheme proposed by the invention is：

Hui ethnic group's Chinese medicine thorn Siberian cocklebur esophaguses of the first, the described prevention and treatment esophageal carcinoma hold back cancer piece and preparation method thereof, are by following heavy Made by amount proportioning raw material：

Ferrum thorn Siberian cocklebur 30g, Rhizoma Curcumae 25g, Herba Sarcandrae 25g, Herba Pteridis Multifidae 25g,

Rhizoma dioscoreae 20g, Rhizoma Polygoni Cuspidati 10g, Radix stephaniae tetrandrae 7g, Radix Panacis Quinquefolii 8g,

Pseudobulbus Cremastrae Seu Pleioness 7g, Sal Ammoniacus 1g, Cortex Eucommiae 7g, Radix Glycyrrhizae 9g

This side is substantially square for one decoction on the one.In practical application, can also be increased according to the body constitution of patient and conditions Theoretical " dialectical compatibility " medicine of the 1-3 taste traditional Chinese medical science " harmony between man and nature, dialectical treatmert ".

In view of with this, basic side's decoction decoction amount is big, taste is not good enough, patient is difficult to drink, therefore must apply special process It is prepared.

2nd, it is by the preparation method that above-mentioned each raw material makes Chinese medicinal tablet of the present invention：

The preparation of A, extract

（1）, extract

A, for the first time extraction：By the weight of said herbal medicine in addition to Sal Ammoniacus, Radix Panacis Quinquefolii, all amplify 10 times, after clean water, It is placed in BT-2 rustless steels to extract in kettle, plus after 7-9 times of tap water, is heated to 100 DEG C of constant temperature and extracts 1 hour or so, separation is carried Liquid is taken, pressure filtration, filtrate is standby.

B, second extraction：Add in kettle the 5-7 times of tap water measured toward extracting, be heated to 100 DEG C of constant temperature and extract half an hour Left and right, extraction fluid, pressure filtration, filtrate is standby.

C, third time are extracted：Add in kettle the 3-5 times of tap water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes Left and right, extraction fluid, pressure filtration, filtrate is standby.

（2）, concentration

The extracting solution of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), 80 DEG C are heated to, relative density 1.10～1.20 is concentrated into, it is standby.

（3）, powder processed

Sal Ammoniacus 1g, Radix Panacis Quinquefolii 8g are amplified into 10 times, it is end together to crush, cross 100 mesh sieves, it is standby.

（4）, dispensing

In 300,000 grades of dust proof workshops, above-mentioned medicated powder is put in mixer together with aforementioned concentrate and is sufficiently mixed, stirring is equal It is even.

(5), drying, crushing

The spice of mix homogeneously is placed in into 60-70 DEG C of baking 4-5 hour in baking oven, is then crushed, cross 100 mesh sieves.

(6), pelletize

The spice of mix homogeneously is inserted into pelletize in comminutor.

(7), granulate

The granule for making is carried out into granulate, 35 mesh sieves are crossed.

(8), it is dried

Whole good granule is inserted in heat circulation drying oven, aeration-drying is to moisture ＜ 8% at 80 DEG C.

(9), tabletting

Magnesium stearate mix homogeneously is added to be placed in tabletting in tablet machine dry mixed gained medicine（Also can coating）, per piece 0.5g。

B, packaging

In first the tablet for pressing being fitted into into vial or vinyon bottle, then by the bottle mounted box for installing, vanning, sterilizing ( Using 60Co irradiation, irradiation dose is 8kGy）.

, warehouse-in

Irradiated finished product is put in storage by the principle of first in first out.

Routine instructions of taking of the invention：Three times a day, 10 tablets once, and on an empty stomach (taking half an hour after can not drink water in a large number, Yi Mianchong Light medicinal liquid).The pungent grade food larger to gastrointestinal irritation is not eaten during medication.

This medicine does extra conductant ingredient and takes better with pan-fried tomato soup.The specific practice of pan-fried tomato soup is：Take from so ripe Saturating little tomato（50 grams or so）Chopping, puts 10 grams or so vegetable oil in pot, heat, and is put into appropriate Flos Allii Fistulosi, Sal, treats Flos Allii Fistulosi Blow out fragrance when the Fructus Lycopersici esculenti of chopping poured into decoct in pot fry 1-2 minutes, then infuse to be got away into suitable quantity of water and take the dish out of the pot.

The effect of each raw material of the present invention：

Ferrum pierces Siberian cocklebur, nature and flavor：It is sweet；Acid；It is mild-natured.Return through：Liver Channel；Kidney channel.Indication：Wind-damp dispelling, diuresis, detumescence poison.Control pass Section pain, muscle is numb, has loose bowels, dysentery, edema, gonorrhea, furuncle, toxic swelling, scrofula, hemorrhoid.Jiangxi《Chinese herbology》：Removing toxic substances is dispelled Wind, is carbuncle sore key medicine.Control severe and migratory arthralgia gout（Rheumatoid arthritiss）, muscular paralysises, esophageal carcinoma, psoriasiss.

Rhizoma Curcumae, nature and flavorEffect：It is bitter in the mouth, pungent, it is warm in nature.Circulation of qi promoting removing blood stasis, Xiao Ji Zhi Tong.It is clinicalUsing：It is mainly used in sonCervix uteri Cancer, apply also for other various tumors such as hepatocarcinoma,Gastric cancer, cancer of pancreas,Ovarian cancer, colon cancer, pulmonary carcinoma,SkinCancer, leukemia, essence Archeocyte cancer, lip cancer, carcinoma vulvae etc..Additionally, this product is additionally operable to treat lump in the abdomen, gastral cavity abdomenDistending pain, food stagnation distending pain, amenorrheaStomachache Deng.

Herba Sarcandrae, nature and flavorEffect：Acrid in the mouth, it is mild-natured.Heat-clearing and toxic substances removing, expelling wind and removing dampness, promoting blood circulation and stopping pain.It is clinicalUsing：It is applied to Kinds of tumors, the such as esophageal carcinoma,Gastric cancer, colon and rectum carcinoma, cancer of pancreas, hepatocarcinoma, acute leukemia etc..

Herba Pteridis Multifidae, containing flavonoid, sterol, ammonia its acid, lactone, phenols and tannin.The property of medicine is bitter, cold.It is Return liver, stomach, lung, big Intestinal, bladder warp.Drug effect internal heat anticance, removing damp-heat, cooling blood for hemostasis.It is medicinal：（1）Internal heat anticance, for carcinoma product poison：Gastric cancer、 Rectal cancer, pulmonary carcinoma etc.；（2）The evanescence of heat that disappears is wet, for damp and hot inflammation：Acute hepatitises etc.；（3）Cooling blood for hemostasis, for heat in blood bleeding：Blood Hot hematuria etc..

Rhizoma dioscoreae, meridian distribution of property and flavor:Sweet in the mouth, it is mild-natured.Returns spleen, lung,Kidney channel.Effect:Spleen reinforcing nourishing the stomach,Promote the production of body fluidLung benefiting,The kidney invigoratingIt is puckery Essence, heat-clearing and toxic substances removing.Cure mainly：It is insufficiency of the spleenLack of appetite, incessant chronic diarrhea, the deficiency of the lung breath with cough,Emission due to deficiency of the kidney, leukorrhagia,Frequent micturition, deficiency-heatQuench one's thirst.In the people Between, Rhizoma Dioscoreae is on record excellent tonic product.It contain protein,Saccharide, vitamin,Fat、Choline、AmylaseDeng composition, Also containing human bodies such as iodine, calcium, ferrum, phosphorusIt is indispensable'sInorganic saltAnd trace element.The traditional Chinese medical science thinks that " main damaging the spleen and stomach qi-restoratives, removes Rhizoma Dioscoreae Cold and heat pathogen, invigorating the spleen and replenishing QI power, long muscle, long term usage normal hearing and eyesight ".Many classic medicine writings have all made very high evaluation to Rhizoma Dioscoreae. Modern medicine study thinks that Rhizoma Dioscoreae has following effect:1. Chinese medicine for lowering blood pressure LIUWEI DIHUANG WAN, Rehmanniae Bolus of Eight Ingredients, 'Guishao Dihuang ball Deng, all it is the famous prescription for having Rhizoma Dioscoreae to be made into, it is applied not only to treat kidney deficiency disease, it is additionally operable to treat hypertension, diabetes, heavy breathing Breathe heavily, the disease such as neurasthenia and lumbago.2. slow down aging modern science proves that Rhizoma Dioscoreae can make the enzymatic activity of acceleration organism aging Significantly reduce.Rehmanniae Bolus of Eight Ingredients containing Rhizoma Dioscoreae, cures mainly sweating continuously due to deficiency after delivery.Protect the clear drop soup of unit, protect the cold drop soup of unit, can control haematemesis and Epistaxiss;It is cold to drench soup and stranguria marked by chyluria soup, pouring worm can be controlled.Rhizoma Dioscoreae can also control pulmonary tuberculosis, typhoid fever and gynaecological disease etc., and this is all conducive to macrobiosis Lengthen one's life.3. antitumor action Rhizoma Dioscoreae tuber is rich in polysaccharide, can stimulate and adjust human immune system.Therefore enhancing immunity energy is often made The health care medicine of power is used.Chinese yam polysaccharide has antagonism to Cellular immunity suppression caused by cyclophosphamide institute, can make to be suppressed Cellular immune function partly or entirely recover normal.Rhizoma Dioscoreae can also strengthen the phagocytosiss of leukocyte.Such as, LIUWEI DIHUANG WAN can The diseases such as treatment chronic nephritiss, hypertension, diabetes, neurasthenia.ZHIBAI DIHUANG WAN can treat ankylosing spondylitiss and gynecological The hyperactivity of fire caused by deficiency of YIN disease such as vaginal bleeding during pregnancy, pudendal pruritus, amenorrhea.'Guishao Dihuang ball can treat otalgia tinnitus, deficiency of YIN spontaneous perspiration etc..4. dermatosiss mountain can be controlled Contained allantoin has the effect of analgesia in medicine, can promote epithelial growth, antiinflammatory and antibacterial, is usually used in treating brothers' chap Split, ichthyosiss and various keratinization dermatoses.Modern science is analyzed, and the maximum feature of Rhizoma Dioscoreae is containing substantial amounts of mucoprotein.It is glutinous Albumen is a kind ofPolysaccharideProteinMixture, there is special health-care effect to human body, can prevent the sedimentation of fat in cardiovascular On, blood vessel elasticity is kept, prevent atherosclerosiss from occurring to early;Subcutaneous fat deposits can be reduced;Connective tissue can be prevented Atrophy, prevents the generation of the collagen such as rheumatoid arthritis, scleroderma.Many nourishing prescriptions, such asLIUWEI DIHUANG WAN、Lycium-rehmannia Ball、GUIPI TANG、The ginseng Siberian cocklebur Rhizoma Atractylodis MacrocephalaeDissipate and wait Chinese medicine all to contain Rhizoma Dioscoreae.

Rhizoma Polygoni Cuspidati, slight bitter is slightly cold.Return liver, gallbladder, lung meridian.It is the dry rhizome of polygonaceae plant Rhizoma Polygoni Cuspidati.Effect：Removing dampness through diuresis and removing jaundice, clearly Thermal detoxification, scattered stasis pain, preventing phlegm from forming and stopping coughing.Pharmacological action：Antibacterial, antiviral, is relievingd asthma at antitussive, clinical practice：1. acute inflammation is treated Property disease, 2. treat burn and scald, 3. treat hepatitis, 4. treat Chronic Airway inflammation, 5. treat leukopenia, 6. treat tooth Bitterly.

Radix stephaniae tetrandrae, nature and flavorEffect：It is bitter in the mouth, pungent, it is cold in nature.Inducing diuresis to remove edema, wind-expelling pain-stopping.It is clinicalUsing：Suitable for variousCancer, such as bladder cancer, pulmonary carcinoma, hepatocarcinoma, kidney arsine tumor.Additionally, this product is additionally operable to rheumatism, edema, arthritis, hypertension Deng.

Radix Panacis Quinquefolii, sweet in the mouth, slight bitter are trembled with fear.Return lung, the heart, kidney, spleen channel.Boosting qi and nourishing yin, relieves inflammation or internal heat and promotes the production of body fluid.Main component is Radix Ginseng Saponin, volatile oil, resin etc..One of Radix Panacis Quinquefolii is good tonic, or ten big Chinese medicine medicine for preventing.Radix Panacis Quinquefolii separates existing with anti- The acetylene-derivative of function of tumor, is preferred than Radix Ginseng effect.Effect：Supplementing QI for promoting the production of body fluid, replenishing YIN and removing heat.Using：Tumour patient symptoms include Restlessness and thirst, chronic cough dry cough caused by deficiency of both QI and YIN, expectorant are spat blood less, shortness of breath and fatigue, dry laryngopharynx, hoarseness, hectic fever in the afternoon, Feverish sensation in the palms and soles etc., can use.

Pseudobulbus Cremastrae Seu Pleiones, nature and flavor are sweet, pungent, cool, mild toxicity.Return liver, kidney, lung, stomach,Large intestine channel.Drug effect：Internal heat anticance,DetumescenceEliminating stagnation.It is clinicalUsing：Suitable for kinds of tumors, it is mainly used inBreast carcinoma, also for malignant lymphoma, thyroid carcinoma,SkinCancer,Cervix uteri Cancer, nasopharyngeal carcinoma, the esophageal carcinoma, leukemia,Gastric cancerDeng.Additionally, applying also for carbuncle furunculosis, lymphoid tuberculosiss, venom and benign swollen Tumor, such as thyroid tumor, cystic hyperplasia of breast, mammary gland fibroma, hemangioma.It is medicinal（1）Internal heat anticance, for carcinoma product poison.

Sal Ammoniacuss, the crystal of halogenation species mineral Sal Ammoniacuss.Nature and flavorEffect：It is salty in the mouth, hardship, pungent, it is warm in nature, it is poisonous.Removing food stagnancy softening the hard mass, Drastically removing blood stasis and resolving static blood.It is clinicalUsing：Suitable for kinds of tumors, such as the esophageal carcinoma,SkinCancer, nasopharyngeal carcinoma,Cervical cancerDeng.Additionally, being additionally operable to Amenorrhea, phlegm retention, sore throat, product dysentery, corneal nebula, polyp, warty vegetation, furuncle, carbuncle, malignant boil etc..

The Cortex Eucommiae, is the dry bark of the Eucommiaceae plant Cortex Eucommiae, is Chinese famous and precious tonic herb.Nature and flavor：It is sweet；Micro-pungent；It is warm in nature. Return through：Liver Channel；Kidney channel.Effect：Invigorating the liver and kidney；Bone and muscle strengthening；Antiabortive gas.The Cortex Eucommiae has invigorating the liver and kidney, and internal rubbish are removed in bone and muscle strengthening, Strengthen human body cell metabolism, prevent muscle skeleton aging, balanced human's blood pressure, decomposer inner cholesterol from reducing internal fat Fat, recovers blood vessel elasticity, and diuresis heat-clearing, broad-spectrum antiseptic, stimulating central nervous system improves white blood cell count, strengthens body immunity Etc. remarkable efficacy.Cure mainly：Spinal column ache；Sexual impotence；Frequent micturition；Dribbling urination；Rheumatic arthralgia；Frequent fetal movement；Habitual abortion.It is suitable for In：1st, instability of kidney QI：Card is shown in frequent micturition or dripping urination, uncontrolled urination, sexual impotence, weak anemia of pregnant woman, frequent fetal movement or waist pendant pain etc..It is many See chronic prostatosiss, sexual dysfunction, infertility, threatened abortion or habitual abortion etc..2nd, caused by liver and kidney deficiency：Card is shown in dizzy Dizzy, soreness of waist and knee joint, muscles and bones flaccidity are weak etc..It is more common in hypertension, vertigo, apoplexy sequela, chronic renal disease, ridge Marrow poliomyelitises etc..3rd, for diseases such as chronic joint diseases, bone tuberculosis, dysmenorrhea, dysfunctional uterine bleeding, chronic pelvic inflammatory diseases And there is caused by liver and kidney deficiency sign person.

Radix Glycyrrhizae, root and root system master contain triterpene saponin, wherein main one kind is commonly called as glycyrrhizin, and the chemical combination of class containing flavone Thing 4',7-Dihydroxyflavanone, liquiritin etc., also compound containing Coumarinses Radix Glycyrrhizae coumarin, glycyol etc., separately gather containing alkaloid, Radix Glycyrrhizae Portugal The compounds such as sugared GBW.Sweet in the mouth, mild-natured, returns spleen, stomach, the heart, lung meridian, invigorating middle warmer and replenishing QI, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, Coordinating the actions of various ingredients in a prescription.Cure mainly asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, loose stool of suffering from abdominal pain, four limbs contraction, hysteria, cough and asthma, Laryngopharynx swelling and pain, ulcerative carbuncle pyogenic infections, infantile carbuncle and medicine, alimentary toxicosis.Radix Glycyrrhizae has removing toxic substances antibacterial action, and anti AIDS virus are made With, Angelica Polysaccharide in vitro to vesicular stomatitis viruss, adenoviruss II types, herpes simplex viruss I type and vaccinia viruss are equal There is obvious inhibiting effect, not only can directly inactivate this several virus, and also have effect to intracellular virus, additionally, sweet Grass also has Antitussive and Expectorant Effect, with antiinflammatory, affects digestive system, immune system and cardiovascular system, antitumor and anti-prominent Change, thyroliberin sample, antioxidation etc. are acted on.The acute and chronic viral hepatitis of clinical treatment, treatment diabetes, treatment Gastric and duodenal ulcers etc..The present invention is to the concocting method of Radix Glycyrrhizae：Extracting liquorice, except removing LU and impurity, size bar is separate, Be dipped to 3 four one-tenth it is saturating when, pick up and soften, cut sheet, be dried.

Fructus Lycopersici esculenti, Fructus Lycopersici esculenti has fat-reducingWeight reducing, allaying tiredness, appetite stimulator, raising to the digestion of protein, reduce stomach The effects such as swollen food stagnation.In recent years, in the anti-cancer or health food that numerous worldwide organizations are recommended, before Fructus Lycopersici esculenti always occupies Row.Find in substantial amounts of epidemiological survey and zoopery, outstanding representation of the Fructus Lycopersici esculenti in cancer-resisting is mostly derived from it In lycopene.So, lycopene be how to give protection against cancer, the first of anticancer, by a series of biochemical action, tomato red Element can promote Carcinoma cell differentiation (to good direction conversion), anticancer propagation.Second, immune function of human body can be strengthened.Kind Lycopene can promote some to have anti-cancer, the such as secretion of the cytokines of antitumaous effect, interleukin-II, activated lymphocyte pair The dissolution of cancerous cell；The lymphocyte being activated can discharge cytokines such as tumor necrosis factor etc. again, have to tumor cell There is lethal effect.3rd, lycopene has strongerAntioxidationEffect.Cell it is aging, damage and canceration all and free radical Effect is relevant, and antioxidant (such as lycopene) is effectively removing free radical, so as to play whole body health-care effect, wherein just It is included in protective effect on cancer risk and plays an important role.

The effect of the present invention：

Cure mainly：The esophageal carcinoma, particularly the early stage esophageal carcinoma, with very low cost, fundamentally improve physical function, control tumor after Continuous overgrowing simultaneously makes it that final disappearance is gradually reduced, so as to recover healthy.

It is simultaneous to control：The cancer in digestive system such as laryngocarcinoma, cardiac cancer, pylorus cancer, gastric cancer, colorectal cancer.

Our the characteristics of is：

1st, flavour of a drug are more, and dosage is moderate, do not waste.

2nd, selected flavour of a drug are all to be proved that for cancer the esophageal carcinoma particularly can be treated by modern medicine pharmacological evaluation 's.And then always have in existing proved recipe for cancer, folk prescription --- even more than medicine more than half be all not by Modern medicine pharmacological evaluation proves function for cancer with effect；

3rd, for focus, arrow arrow punching, i.e., selected flavour of a drug all especially grow tender of and hit the bull's eye, and As the medicine took effect, the symptoms lessened.Rather than only It is for cancer, just jump on the bandwagon, as a result it is that " dragon " does not harness the river on the contrary more.

4th, as much as possible " neutralization ", i.e., selected flavour of a drug generally keep " neutrality ", do not tremble with fear not dry, not hot not cool.This Sample can just make patient suffer less within the cycle of whole medication, pull the devil by the tail less.And if really occurring " getting angry " or " under let out " Situation, then can be directed to concrete individual concrete condition completely, a bit " stopping leak ", the medicine of " pathogenic fire reducing " are specifically solved for interim addition Certainly.Rather than imagine at the very start patient may on tell or drop, and some unnecessary medicine sides of being added to Son, makes patient all take always during very long very long medication, ultimately causes adverse consequencess.

Specific embodiment：Ferrum is pierced into Siberian cocklebur 30g, Rhizoma Curcumae 25g, Herba Sarcandrae 25g, Herba Pteridis Multifidae 25g, Rhizoma dioscoreae 20g, Rhizoma Polygoni Cuspidati 10g, Radix stephaniae tetrandrae 7g, Pseudobulbus Cremastrae Seu Pleioness 7g, Cortex Eucommiae 7g, Radix Glycyrrhizae 9g respectively amplify 10 times, after clean water, are placed in the extraction of BT-2 rustless steels In kettle, plus after 7-9 times of tap water, it is heated to 100 DEG C of constant temperature and extracts 1 hour or so, extraction fluid, pressure filtration, filtrate is standby With.Extract for second：Add in kettle the 5-7 times of tap water measured toward extracting, be heated to 100 DEG C of constant temperature and extract or so half an hour, point From extracting solution, pressure filtration, filtrate is standby.Third time is extracted：Add in kettle the 3-5 times of tap water measured toward extracting, be heated to 100 DEG C constant temperature is extracted 20 minutes or so, and extraction fluid, pressure filtration, filtrate is standby.Concentration：The extracting solution of three times is merged, is put In B-500 type triple effect vacuum high energy evaporation concentrators, reduce pressure (negative 200mmHg), be heated to 80 DEG C, be concentrated into relative density 1.10～1.20, it is standby.Powder processed：Radix Panacis Quinquefolii 8g, Sal Ammoniacus 1g are respectively amplified 10 times, it is end together to crush, and crosses 100 mesh sieves, standby With.Dispensing：In 300,000 grades of dust proof workshops, above-mentioned medicated powder is put in mixer together with aforementioned concentrate and 30g Mel and is filled Divide mixing, stir.Drying, crushing：The spice of mix homogeneously is placed in into 60-70 DEG C of baking 4-5 hour in baking oven, then powder It is broken, cross 100 mesh sieves.Pelletize：The spice of mix homogeneously is inserted into pelletize in comminutor.Granulate：The granule for making is carried out whole Grain, crosses 35 mesh sieves.It is dried：Whole good granule is inserted in heat circulation drying oven, aeration-drying is to moisture ＜ 8% at 80 DEG C.Pressure Piece：Magnesium stearate mix homogeneously is added to be placed in tabletting in tablet machine dry mixed gained medicine（Also can coating）, per piece 0.5. Packaging：In first the tablet for pressing being fitted into into vial or vinyon bottle, then by the bottle mounted box for installing, vanning, sterilizing (60Co irradiation is adopted, irradiation dose is 8kGy）.Finally, irradiated finished product is put in storage by the principle of first in first out.

Claims (2)

1. Hui ethnic group's Chinese medicine " thorn Siberian cocklebur esophaguses hold back cancer piece " and preparation method thereof, it is characterised in that it is by the raw material of following weight proportion Made by：

Ferrum thorn Siberian cocklebur 30g, Rhizoma Curcumae 25g, Herba Sarcandrae 25g, Herba Pteridis Multifidae 25g,

Rhizoma dioscoreae 20g, Rhizoma Polygoni Cuspidati 10g, Radix stephaniae tetrandrae 7g, Radix Panacis Quinquefolii 8g,

Pseudobulbus Cremastrae Seu Pleioness 7g, Sal Ammoniacus 1g, Cortex Eucommiae 7g, Radix Glycyrrhizae 9g

This side is the substantially square of one decoction on the one, in practical application, can also be increased according to the body constitution of patient and conditions Theoretical " dialectical compatibility " medicine of the 1-3 taste traditional Chinese medical science " harmony between man and nature, dialectical treatmert ".

2. the weight proportion of Hui ethnic group's Chinese medicine " thorn Siberian cocklebur esophaguses hold back cancer piece " according to claim 1, it is characterised in that under including State preparation process：

The preparation of A, extract

（1）, extract

A, for the first time extraction：By the weight of said herbal medicine in addition to Sal Ammoniacus, Radix Panacis Quinquefolii, all amplify 10 times, after clean water, It is placed in BT-2 rustless steels to extract in kettle, plus after 7-9 times of tap water, is heated to 100 DEG C of constant temperature and extracts 1 hour or so, separation is carried Liquid is taken, pressure filtration, filtrate is standby；

B, second extraction：Add in kettle the 5-7 times of tap water measured toward extracting, be heated to 100 DEG C of constant temperature extraction half an hour left The right side, extraction fluid, pressure filtration, filtrate is standby；

C, third time are extracted：Add in kettle the 3-5 times of tap water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes or so, Extraction fluid, pressure filtration, filtrate is standby；

（2）, concentration

The extracting solution of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), 80 DEG C are heated to, relative density 1.10～1.20 is concentrated into, it is standby；

（3）, powder processed

Sal Ammoniacus 1g, Radix Panacis Quinquefolii 8g are amplified into 10 times, it is end together to crush, cross 100 mesh sieves, it is standby；

（4）, dispensing

In 300,000 grades of dust proof workshops, above-mentioned medicated powder is put in mixer together with aforementioned concentrate and is sufficiently mixed, stirring is equal It is even；

(5), drying, crushing

The spice of mix homogeneously is placed in into 60-70 DEG C of baking 4-5 hour in baking oven, is then crushed, cross 100 mesh sieves；

(6), pelletize

The spice of mix homogeneously is inserted into pelletize in comminutor；

(7), granulate

The granule for making is carried out into granulate, 35 mesh sieves are crossed；

(8), it is dried

Whole good granule is inserted in heat circulation drying oven, aeration-drying is to moisture ＜ 8% at 80 DEG C；

(9), tabletting

Magnesium stearate mix homogeneously is added to be placed in tabletting in tablet machine dry mixed gained medicine（Also can coating）, per piece 0.5g；

B, packaging

In first the tablet for pressing being fitted into into vial or vinyon bottle, then by the bottle mounted box for installing, vanning, sterilizing ( Using 60Co irradiation, irradiation dose is 8kGy）；

C, warehouse-in

Irradiated finished product is put in storage by the principle of first in first out.