CN106668418A - Hui nationality traditional Chinese medicine tablets for treating esophagus cancer and preparation method thereof - Google Patents

Abstract

The invention relates to Hui nationality traditional Chinese medicine tablets for treating esophagus cancer and a preparation method thereof. The traditional Chinese medicine tablets for treating esophagus cancer are a Chinese herbal medicine product having advantages of environmental protection as well as high science and technology, which take bushy sophora, Chinese aralia, dark plum, and Semen Cuscutae according to a certain proportion, the above Chinese herbal medicines are mixed, water is added in a mixture, the mixture is decocted, extracted, concentrated, and tabletted to obtain the product. The traditional Chinese medicine tablets are mainly used for treating esophagus cancer, and treating digestive system cancers such as pharyngolaryngeal cancer, stomach cancer and colorectal cancer, and have the characteristics of moderate flavor and dosage, the selected Chinese herbal medicines are proved for treating cancer by modern medical pharmacological experiments, with low cost, the body function can be fundamentally improved, cell cancerization is prevented, and body health is recovered.

Description

Hui ethnic group's Chinese medicine esophaguses hold back cancer piece and preparation method thereof

Technical field

It is a kind of green high-tech Chinese herbal medicine of the prevention and treatment esophageal carcinoma that Hui ethnic group's Chinese medicine esophaguses according to the present invention hold back cancer piece.The invention further relates to the preparation method of the medicine, belongs to Chinese medicine class.

Background technology

According to《China's tumour registration annual report in 2014》Data display, according to China's Life Calculation of 74 years old for each person, the probability that Chinese suffer from malignant tumor in all one's life is 22%, and average minute clock has 6 people to be diagnosed as malignant tumor, and tumor has become a kind of common disease in China.At present the cancer patient of China is about ten thousand people more than 700, and every year with the speed of more than 100 ten thousand people in increase.And the whole world

According to statistics, in the cancer patient of China nearly 8,000,000, have 31.27% for digestive system cancer patient, wherein patient with esophageal carcinoma accounts for the 29.7% of digestive system cancer patient, almost half.

Esophageal carcinomaDisease locus are typically organized in epithelium of esophagus, and it is exactly swallowing and digestive function for patient that it directly affects, and health is slowly etched with regard to this.The pathogenic factor of esophageal carcinoma mainly has three, and one is malnutrition, though that is, now the living standard of people improves, due to the change of diet hobby and mode, will also result in the shortage of malnutrition and trace element；Two is that diet is lack of standardization, and in the grain and drinking-water of district occurred frequently, nitrate, nitrite and secondary amine content significantly increase, and these materials are easily-synthesized carcinogen nitrosamine in gastric；Three is esophageal injury and disease induction, and esophageal injury and some esophagel diseases are likely to become the inducement for causing esophageal carcinoma, and long-term chronic inflammatory disease, ulcer, or chronic stimulation, and then esophageal epithelial proliferation are caused because of being detained in esophaguses, finally result in canceration.Although esophageal carcinoma does not possess infectiousness, the destruction to human body is but not allow to look down upon.

Though the early symptom of the esophageal carcinoma is more substantially, generally always flu etc is mistakenly considered by people, therefore often ignored, but do not know that the speed that esophageal carcinoma slowly deteriorates is very fast, once and feel increasingly apparent to be difficult to swallow, most likely deteriorated as cancer.Afterwards may be by operation to the process of cancerization Regional resection, to reduce the mortality rate of esophageal carcinoma.

At present treatment esophageal carcinoma the best way is operation, postoperative to be also performed to chemotherapy, and chemotherapy not only large side effects, patient suffering is difficult to stand, and success rate is also very low, the life cycle after most Chemotherapy in Patients was with regard to 1 year or so --- certainly this is also relevant with the over-treatment given birth to without skilful doctor.And on the other hand, although some perform the operation, held due to a variety of causes and can't stand chemotherapy,Can only palliative treatment, expect that miracle comes ...

The esophageal carcinoma is disease at present compared with refractory more as gastric cancer, all, but refractory is not represented and cannot controlled, and in addition to above-mentioned western medical treatment method, the traditional Chinese medical science also has many effectively Therapeutic Method.The traditional Chinese medical science, according to the whole body feature determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of patient, goes for various each phase cancer with organic conception.The advantage of Chinese medicine cancer is to be conducive to stablizing the state of an illness, and toxic and side effects are slight, symptom improves more apparent, slows down PD, tumor regression or the longer-term existence of band tumor, and patient is easy to receive and expense is than less expensive.At present doctor trained in Western medicine is also considered as Chinese medicine can contribute to reducing the toxicity of Radiotherapy chemotherapy as the auxiliary treatment of cancer, improve cancer related symptoms, improve life quality, extend life cycle.But exist problem be the traditional Chinese medical science prescription uniformity it is poor, treatment mainly be experience.From in terms of existing proved recipe for cancer, folk prescription, always there is --- majority is more than more than half --- medicine to be all not prove " compatibility " medicine of function for cancer and effect " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs " by modern medicine pharmacological evaluation in selected Chinese herbal medicine medical material, inventors believe that very improper；And folk prescription, folk prescription cure the disease lean on be test, often stop over the time cured the disease.

The content of the invention

The purpose of the present invention, be aiming at Cancer in China patient assessment be difficult to and in the side's of curing the desease poor consistency, repeatable poor, high level evidence-based medicine EBM be theoretical and the relative shortage of evidence,Thus the situation for waiting deficiency by rule of thumb that is mainly for cancer, propose a kind of new dosage and preparation method, there is provided one kind reduces the sickness rate of the esophageal carcinoma from the beginning of prevention, start to slow down its tempo from canceration, the green high-tech Chinese herbal medicine for inducing its atrophy apoptosis is started from tumor.Specifically, the present invention one is particularly suited for use in esophageal ulcer before treatment cancer in case its canceration, two is can to treat cancer just ulcer, in case it continues to deteriorate, three is inducible into the cancerous protuberance atrophy apoptosis of tumor, with very low cost, fundamentally improve physical function, so as to get well.Its sharpest edges are to greatest extent to induce self apoptosis of cancerous cell and differentiation, promote cancerous protuberance progressively atrophy.In specific formula, also coordinate determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, induced because of esophageal injury, disease according to the origin cause of formation of esophageal carcinoma, dietary preferences nutrient imbalance causes immunologic hypofunction, cause normal cell to be compromised because of Helicobacter pylori infection, apoptosis, digestive tract ulcer, canceration " taking advantage of a weak point ", because " weakened body resistance poison poly- ", " healthy energy interior-deficiency " and the characteristics of causes the basic pathology pathogenesis such as neoplasm metastasis, utilization or strengthening vital QI to eliminate pathogenic factors, orReinforcement and elimination in combination, or regulating qi to disperse stagnation, or resolving depression resolving sputum, or heat-clearing and toxic substances removing, or reinforcing and reducing and the method used, to correct healthy energy interior-deficiency, poly- and internal organs imbalance of YIN and YANG function reduction the deficiency of the solidifying poison of heresy, adjust and improve the immunologic function of body, to reach the purpose of overall tumor suppression, so as to improve the overall curative effect and late result of carninomatosis treatment, a kind of green high-tech Chinese herbal medicine formula and compound method that function for cancer and effect are proved by modern medicine pharmacological evaluation is provided for esophageal cancer patients, with very low or relatively low cost, fundamentally improve physical function, the deterioration of symptom management simultaneously makes the state of an illness gradually take a turn for the better, finally recover healthy.Thus also to patient one select different treatment methods or several method to share particularly Chinese and western medicine to combine the leeway of Comprehensive Treatment application to consider according to the personal state of an illness, economic situation, personal inclination, to obtaining optimum curative effect, survival rate is easily improved --- particularly more than 5 years survival rates.

Technical scheme proposed by the invention is：

Hui ethnic group's Chinese medicine esophaguses of the first, the described prevention and treatment esophageal carcinoma hold back cancer piece and preparation method thereof, are by made by following weight proportion raw material：

Radix Sophorae Tonkinensiss 30g, neglect wood 20g, Rhizoma Dioscoreae Bulbiferae 7g, Fructus Mume 9g,

Semen Cuscutae 10g, Lentinus Edodess 9g, pellet feed 10g, Cortex Ailanthi 7g,

Rhizoma dioscoreae 20g, Radix Glycyrrhizae 7g, Mel 30g,

This side is substantially square for one decoction on the one.In practical application, also the 1-3 taste traditional Chinese medical science " harmony between man and nature, dialectical treatmert " theory can be increased according to the body constitution of patient and conditions“Dialectical compatibility " medicine.

In view of with this, basic side's decoction decoction amount is big, taste is not good enough, patient is difficult to drink, therefore must be prepared using special process.

2nd, it is by the preparation method that above-mentioned each raw material makes Chinese medicinal tablet of the present invention：

A, extract preparation

（1）, extract

A, for the first time extraction：By the weight of said herbal medicine in addition to Cortex Ailanthi, Radix Glycyrrhizae, all amplify 10 times, after clean water, be placed in BT-2 rustless steels and extract in kettle, plus after 7-9 times of tap water, be heated to 100 DEG C of constant temperature and extract 1 hour or so, extraction fluid, pressure filtration, filtrate is standby.

B, second extraction：Add in kettle the 5-7 times of tap water measured toward extracting, be heated to 100 DEG C of constant temperature and extract or so half an hour, extraction fluid, pressure filtration, filtrate is standby.

C, third time are extracted：Add in kettle the 3-5 times of tap water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes or so, extraction fluid, pressure filtration, filtrate is standby.

（2）, concentration

The extracting solution of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), be heated to 80 DEG C, be concentrated into relative density 1.10～1.20, it is standby.

（3）, powder processed

Cortex Ailanthi 7g, Radix Glycyrrhizae 7g are amplified into 10 times, it is end together to crush, cross 100 mesh sieves, it is standby.

（4）, dispensing

In 300,000 grades of dust proof workshops, above-mentioned medicated powder is put in mixer together with aforementioned concentrate and is sufficiently mixed, stir.

(5) drying, crushing

The spice of mix homogeneously is placed in into 60-70 DEG C of baking 4-5 hour in baking oven, is then crushed, cross 100 mesh sieves.

(6) pelletize

The spice of mix homogeneously is inserted into pelletize in comminutor.

(7) granulate

The granule for making is carried out into granulate, 35 mesh sieves are crossed.

(8) it is dried

Whole good granule is inserted in heat circulation drying oven, aeration-drying is to moisture ＜ 8% at 80 DEG C.

(9) tabletting

Magnesium stearate mix homogeneously is added to be placed in tabletting in tablet machine dry mixed gained medicine（Also can coating）, every 0.5g.

B, packaging

In first the tablet for pressing being fitted into into vial or vinyon bottle, then the bottle mounted box for installing, vanning, sterilizing (are adopted into 60Co irradiation, irradiation dose is 8kGy）.

C, warehouse-in

Irradiated finished product is put in storage by the principle of first in first out.

Routine instructions of taking of the invention：Three times a day, each 14-16 pieces, on an empty stomach (taking half an hour after can not drink water in a large number, in order to avoid water down medicinal liquid).The pungent grade food larger to gastrointestinal irritation is not eaten during medication.

This medicine does extra conductant ingredient and takes better with pan-fried tomato soup.The specific practice of pan-fried tomato soup is：Take from so well-done little tomato（50 grams or so）Chopping, puts 10 grams or so vegetable oil in pot, heat, and is put into appropriate Flos Allii Fistulosi, Sal, pours into be decocted in pot by the Fructus Lycopersici esculenti of chopping when Flos Allii Fistulosi blows out fragrance and fries 1-2 minutes, then infuses to be got away into suitable quantity of water and take the dish out of the pot.

The effect of each raw material of the present invention：

Radix Sophorae Tonkinensiss,ForLeguminous plant root of subprostrate sophoraRoot.Bitter in the mouth cold in nature.Effect is to relieve inflammation or internal heat, detoxifying, subsiding a swelling, pain relieving.Cure mainly：Laryngalgia, acute throat trouble,Sore throat,Gingival swelling and pain,Dyspnea with fullness of the chestHeat syndrome cough,Jaundice, dysentery, heat is swollen,Scabies, snakeworm lyssodexis.Its is rightThe esophageal carcinoma、Nasopharyngeal carcinoma, cervical cancer,Bladder cancer, leukaemia have inhibitory action.Composition pharmacology：Containing total alkaloidss about 0.93%, whereinMatrine(Matrine) 0.52%,Oxymatrine(Oxymatrine) 0.35%, Yi JihanD-maackianin-β-D-glucoside(Sophoraponicin)、Lignum pterocarpi indiciPlain (Pterorepine),Screw oil expeller axleGrass roots glycoside (TrifolirhiZin),Albizzia kalkoraPlain (Maackian), sophoradin (Sophra) etc..DNA and RNA synthesis of the Radix Sophorae Tonkinensiss to tumor cell has obvious inhibitory action, so as to block the propagation of tumor cell, lymphocyte transformations can be promoted, excite or strengthen the cytotoxicity of lymphocyte, T cell ratio is improved, strengthens or adjust macrophage phagocytic function, moreover it is possible to endocrine regulation, the function of adrenal cortex reinforcing, thus affects the occurrence and development of tumor.

It is suddenly wooden,Containing araloside suddenly, protocatechuic acid, choline and volatile oil etc..The property of medicine is sweet, pungent, puts down.Return liver, gallbladder, stomach, large intestine, lung, kidney channel.Drug effect：Internal heat anticance, antiinflammatory detumescent, damp eliminating diuretic.Medicinal (1) internal heat anticance, for carcinoma product poison：Cancer of biliary duct, gastric cancer, rectal cancer, pulmonary carcinoma etc.；(2) antiinflammatory detumescent, swells and ache for inflammation：Cystitis；(3) damp eliminating profit fire, for edema caused by wind-dampness：Oedema due to nephritis.Nature and flavorEffect：It is bitter in the mouth, cold in nature.Heat clearing and damp drying, eliminating fire and detoxication.It is clinicalUsing：Suitable for various arsine tumors, such as liver, gallbladder tumor, carcinoma of tongue, lip cancer, the esophageal carcinoma,Gastric cancer, bladder cancer etc..

Rhizoma Dioscoreae Bulbiferae,Nature and flavorEffect：Bitter in the mouth, it is mild-natured, it is slightly poisonous.Removing toxic substances and promoting subsidence of swelling, dissipating phlegm and resolving masses, cooling blood for hemostasis.It is clinicalUsing：Suitable for kinds of tumors, such as the esophageal carcinoma,Gastric cancer, nasopharyngeal carcinoma, thyroid tumor, lymphosarcoma, pulmonary carcinoma, sonCervical cancer, rhabdomyosarcoma, intestinal cancer and cancer of pancreas etc..Additionally, applying also for big endemic goiter, hyperthyroidism, tracheitiies, pertussis, hemoptysis, haematemesis, scrofula, skin infection tumor, venom etc..

Fructus Mume,Nature and flavorEffect：Sour-puckery flavor, it is warm in nature.Astringe the lung astringing intestine to stop diarrhea, promoting the production of body fluid to quench thirst.CanTreatmentCancerous protuberance.Be clinically used for treat carcinoma of penis,Cervical cancer, colon and rectum carcinoma, the esophageal carcinoma,Gastric cancerDeng.Additionally, being additionally operable to treat chronic cough of deficiency lung, xerostomia excessive thirst, biliary tract ascarid, cholecystitis, bacillary dysentery, chronicDiarrhoea, Lu pass through many, psoriasiss.External curing infectionss do not close up long, clavuss etc..

Semen Cuscutae,It is warm in nature；Sweet in the mouth；Return liver, spleen, kidney channel.Effect and effect nourishing the liver and kidney, antiabortive, improving eyesight, antidiarrheal.For：Impotence and seminal emission, dripping urination, enuresis frequent micturition, medicine knees soreness, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen kidney deficiency is rushed down；Externally treating leucoderma, the ability with certain anticancer can reduce the incidence rate of canceration.

Lentinus Edodess,Lentinus Edodess are cold in nature, mildly bitter flavor, favourable liver stomach reinforcingEffect.Lentinus Edodess not only have the peculiar flavour of delicate fragrance, and containing abundant composition calcium, phosphorus, the ferrum beneficial to human body, also containing polysaccharide, vitamin B1, vitamin B2, vitamin C etc..Containing the composition such as several amino acids, acetamide, choline, adenine in the infusion of dried thin mushroom, the cholesterol in blood can be reduced, atherosclerosis, to prevent and treat cerebral hemorrhage, heart disease, obesity andDiabetesIt is all effective.In recent years, American scientist find in Lentinus Edodess containing it is a kind of " β-Fructus Vitis viniferaeGlycosidase ", test proves that this material plays the role of significantly to strengthen body against cancer, therefore, people call Lentinus Edodess " anticancer new recruit ".Lentinus Edodess are also resistant toFluVirus, because containing a kind of derivant of interferon, the generation of energy inductor internal interference element, the synthesis of viral interference protein so as to irreproducible, so that human body produces immunization in Lentinus Edodess.Ancient Times in China scholar early has found perfume (or spice)Mushrooms foodIt is improved the effect of function of brain cell.Such as《Legendary god of farming's book on Chinese herbal medicine》In just have take bait mushroom can be with " increasing wisdom ", the record of " Fructus Alpiniae Oxyphyllae is happy ".Modern medicine thinks that the increasing intelligence effect of Lentinus Edodess is, containing abundant arginine and lysine, often to eat, and can be healthy and strong Fructus Alpiniae Oxyphyllae.

Pellet feeds,Nature and flavorEffect：Bitter in the mouth, cold nature.Stasis-dispelling and pain-killing, promoting blood flow to regulate menstruation, nourishing heart relieving restlessness.It is clinicalUsing：Suitable for the digestive tract tumor accumulate in stagnation of QI-blood, pyretic toxicity, the osteosarcoma or bone metastaes of stasis meridians are additionally operable to.Additionally, being usually used inTreatment menoxenia, amenorrhea,Ectopic pregnancy, hepatosplenomegaly, angina pectoriss, dysphoria and insomnia, sore swollen toxin.

Cortex Ailanthi,Nature and flavorEffect：Root bark bitter in the mouth, puckery, cold in nature, dampness heat clearing away, antidiarrheal, hemostasis.Fruit bitter in the mouth, cool in nature, clearing away heat and promoting diuresis, pain relieving, hemostasis.It is clinicalUsing：Suitable for colon and rectum carcinoma,Cervical cancerDeng.Additionally, Cortex Ailanthi apply also for chronic dysentery, enteritis, have blood in stool, pass out semen, leucorrhea, featureUterusBleeding.Fruit applies also for having a stomachache, has blood in stool, hematuria;Trichomonas vaginitises are controlled in external.

Rhizoma dioscoreae,Meridian distribution of property and flavor:Sweet in the mouth, it is mild-natured. Returns spleen, lung,Kidney channel.Effect:Spleen reinforcing nourishing the stomach,Promote the production of body fluidLung benefiting,The kidney invigoratingArresting seminal emission, heat-clearing and toxic substances removing.Cure mainly：It is insufficiency of the spleenLack of appetite, incessant chronic diarrhea, the deficiency of the lung breath with cough,Emission due to deficiency of the kidney, leukorrhagia,Frequent micturition, deficiency-heatQuench one's thirst.Among the people, Rhizoma Dioscoreae is on record excellent tonic product.It contain protein,Saccharide, vitamin,Fat、Choline、AmylaseDeng composition, also containing human bodies such as iodine, calcium, ferrum, phosphorusIt is indispensable'sInorganic saltAnd trace element.The traditional Chinese medical science thinks, Rhizoma Dioscoreae " main damaging the spleen and stomach qi-restoratives, except cold and heat pathogen, invigorating the spleen and replenishing QI power, long muscle, long term usage normal hearing and eyesight ".Many classic medicine writings have all made very high evaluation to Rhizoma Dioscoreae.Modern medicine study thinks that Rhizoma Dioscoreae has following effect:1. Chinese medicine for lowering blood pressure LIUWEI DIHUANG WAN, Rehmanniae Bolus of Eight Ingredients, 'Guishao Dihuang ball etc., are all the famous prescriptions for having Rhizoma Dioscoreae to be made into, and are applied not only to treat kidney deficiency disease, are additionally operable to treat the diseases such as hypertension, diabetes, asthma, neurasthenia and lumbago.2. slow down aging modern science proves that Rhizoma Dioscoreae significantly reduces can the enzymatic activity of acceleration organism aging.Rehmanniae Bolus of Eight Ingredients containing Rhizoma Dioscoreae, cures mainly sweating continuously due to deficiency after delivery.Protect the clear drop soup of unit, protect the cold drop soup of unit, haematemesis and epistaxiss can be controlled;It is cold to drench soup and stranguria marked by chyluria soup, pouring worm can be controlled.Rhizoma Dioscoreae can also control pulmonary tuberculosis, typhoid fever and gynaecological disease etc., and this is all conducive to life lengthening.3. antitumor action Rhizoma Dioscoreae tuber is rich in polysaccharide, can stimulate and adjust human immune system.Therefore the health care medicine for often making to strengthen immunocompetence is used.Chinese yam polysaccharide has antagonism to Cellular immunity suppression caused by cyclophosphamide institute, and repressed cellular immune function can be made partly or entirely to recover normal.Rhizoma Dioscoreae can also strengthen the phagocytosiss of leukocyte.Such as, LIUWEI DIHUANG WAN can treat the diseases such as chronic nephritiss, hypertension, diabetes, neurasthenia.ZHIBAI DIHUANG WAN can treat the hyperactivity of fire caused by deficiency of YIN disease such as ankylosing spondylitiss and gynecological's vaginal bleeding during pregnancy, pudendal pruritus, amenorrhea.'Guishao Dihuang ball can treat otalgia tinnitus, deficiency of YIN spontaneous perspiration etc..4. the effect that allantoin contained in dermatosiss Rhizoma Dioscoreae has analgesia can be controlled, epithelial growth, antiinflammatory and antibacterial can be promoted, be usually used in treating rhagadia manus et pedis, ichthyosiss and various keratinization dermatoses.Modern science is analyzed, and the maximum feature of Rhizoma Dioscoreae is containing substantial amounts of mucoprotein.Mucoprotein is a kind ofPolysaccharideProteinMixture, there is special health-care effect to human body, can prevent the sedimentation of fat on cardiovascular, blood vessel elasticity is kept, prevent atherosclerosiss from occurring to early;Subcutaneous fat deposits can be reduced;The atrophy of connective tissue can be prevented, prevents the generation of the collagen such as rheumatoid arthritis, scleroderma.Many nourishing prescriptions, such asLIUWEI DIHUANG WAN、Qi Ju Dihuang ball、GUIPI TANG、The ginseng Siberian cocklebur Rhizoma Atractylodis MacrocephalaeDissipate and wait Chinese medicine all to contain Rhizoma Dioscoreae.

Radix Glycyrrhizae,Root and root system master contain triterpene saponin, wherein main one kind is commonly called as glycyrrhizin, and the 4',7-Dihydroxyflavanone of chlorins compound containing flavone, liquiritin etc., the also Radix Glycyrrhizae of compound containing Coumarinses coumarin, glycyol etc., separately containing compounds such as alkaloid, Radix Glycyrrhizae glucosan GBW.Sweet in the mouth, mild-natured, returns spleen, stomach, the heart, lung meridian, invigorating middle warmer and replenishing QI, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Cure mainly asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, suffer from abdominal pain loose stool, four limbs contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, ulcerative carbuncle pyogenic infections, infantile carbuncle and medicine, alimentary toxicosis.Radix Glycyrrhizae has removing toxic substances antibacterial action, anti-AIDS toxic action, Angelica Polysaccharide has obvious inhibiting effect to vesicular stomatitis viruss, adenoviruss II types, herpes simplex viruss I type and vaccinia viruss in vitro, not only can directly inactivate this several virus, and also have effect to intracellular virus, additionally, Radix Glycyrrhizae also has Antitussive and Expectorant Effect, with antiinflammatory, affect digestive system, immune system and cardiovascular system, the effect such as antitumor and mutation, thyroliberin sample, antioxidation.The acute and chronic viral hepatitis of clinical treatment, treatment diabetes, treatment gastric and duodenal ulcers etc..The present invention is to the concocting method of Radix Glycyrrhizae：Extracting liquorice, except removing LU and impurity, size bar is separate, be dipped to 3 four one-tenth it is saturating when, pick up and soften, cut sheet, be dried.

Mel,Effect of Mel and effect：1. the good merchantable brand of cardiovascular patient,MelThe composition of blood can be improved, promote heart and brain and vascular function, therefore Jing informal dresses very good for cardiovascular patient；2. the liver protecting, Mel has protective effect, can promote liver cell regeneration to liver, and the formation to fatty liver has certain inhibitory action；3. build up resistance, edible Mel can regain one's strength of body rapidly, allaying tiredness builds up one's resistance to disease；4. sterilize, Mel also has the effect for sterilizing, Jing often to eat Mel, not only without prejudice to tooth, moreover it is possible to play a part of sterilizing in oral cavity, Mel can treat the skin damage of moderate, particularly scald, when Mel is regarded into skin wound dressing, antibacterial cannot grow；5. hypnotic, the people of the insomnia oral 1 soupspoon Mel (in 1 glass of warm water of addition) before sleep daily, can help fall asleep as early as possible；6. promote gastrointestinal peristalsiss, Mel to have adjustment effect to gastrointestinal function, gastric acid secretion can be made normal.Zoopery confirms that Mel plays the role of to strengthen enterokinesia, can significantly shorten defecation time.

Fructus Lycopersici esculenti,Fructus Lycopersici esculenti has fat-reducing Weight reducing , allaying tiredness, appetite stimulator, raising to the digestion of protein, reduce flatulence food stagnation the effects such as.In recent years, in the anti-cancer or health food that numerous worldwide organizations are recommended, Fructus Lycopersici esculenti always ranks among the best.Find in substantial amounts of epidemiological survey and zoopery, outstanding representation of the Fructus Lycopersici esculenti in cancer-resisting is mostly derived from lycopene therein.So, lycopene be how to give protection against cancer, the first of anticancer, by a series of biochemical action, lycopene can promote Carcinoma cell differentiation (to good direction conversion), anticancer propagation.Second, immune function of human body can be strengthened.Lycopene can promote some to have anti-cancer, the such as secretion of the cytokines of antitumaous effect, interleukin-II, dissolution of the activated lymphocyte to cancerous cell；The lymphocyte being activated can discharge cytokines such as tumor necrosis factor etc. again, have to tumor cellKillEffect.3rd, lycopene has stronger Antioxidation Effect.The aging of cell, damage are all relevant with Free Radical with canceration, and antioxidant (such as lycopene) is effectively removing free radical, so as to play whole body health-care effect, wherein be just included in protective effect on cancer risk playing an important role.

The effect of the present invention：

Cure mainly：The esophageal carcinoma, particularly the early stage esophageal carcinoma, with very low cost, fundamentally improve physical function, and control tumor continues to overgrow and makes it that final disappearance is gradually reduced, so as to recover healthy.

It is simultaneous to control：The cancer in digestive system such as laryngocarcinoma, cardiac cancer, pylorus cancer, gastric cancer, colorectal cancer.

Our the characteristics of is：

1st, flavour of a drug are more, and dosage is moderate, do not waste.

2nd, selected flavour of a drug are all to be proved that for cancer the esophageal carcinoma particularly can be treated by modern medicine pharmacological evaluation.And then always have in existing proved recipe for cancer, folk prescription --- even more than medicine more than half be all not by modern medicine pharmacological evaluation proved function for cancer and effect.

3rd, for focus, arrow arrow punching, i.e., selected flavour of a drug all especially grow tender of and hit the bull's eye, and As the medicine took effect, the symptoms lessened.As long as rather than it is for cancer, just jump on the bandwagon, be as a result that " dragon " does not harness the river on the contrary more.

4th, as much as possible " neutralization ", i.e., selected flavour of a drug generally keep " neutrality ", do not tremble with fear not dry, not hot not cool.Patient can be thus set to suffer less within the cycle of whole medication, pull the devil by the tail less.And if really there is the situation of " getting angry " or " under let out ", then can be directed to concrete individual concrete condition completely, a bit " stopping leak ", the medicine of " pathogenic fire reducing " are specifically solved for interim addition.Rather than imagine at the very start patient may on tell or drop, and some unnecessary medicines are added to prescription, patient is all taken always during very long very long medication, ultimately cause adverse consequencess.

Specific embodiment：By Radix Sophorae Tonkinensiss 30g, suddenly wood 20g, Rhizoma Dioscoreae Bulbiferae 7g, Fructus Mume 9g, Semen Cuscutae 10g, Lentinus Edodess 9g, pellet feed, and 10g, Rhizoma dioscoreae 20g are each to amplify 10 times, after clean water, it is placed in BT-2 rustless steels to extract in kettle, plus after 7-9 times of tap water, it is heated to 100 DEG C of constant temperature to extract 1 hour or so, extraction fluid, pressure filtration, filtrate is standby.Extract for second：Add in kettle the 5-7 times of tap water measured toward extracting, be heated to 100 DEG C of constant temperature and extract or so half an hour, extraction fluid, pressure filtration, filtrate is standby.Third time is extracted：Add in kettle the 3-5 times of tap water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes or so, extraction fluid, pressure filtration, filtrate is standby.Concentration：The extracting solution of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), be heated to 80 DEG C, be concentrated into relative density 1.10～1.20, it is standby.Powder processed：Cortex Ailanthi 7g, Radix Glycyrrhizae 7g are respectively amplified 10 times, it is end together to crush, and crosses 100 mesh sieves, standby.Dispensing：In 300,000 grades of dust proof workshops, above-mentioned medicated powder is put in mixer together with aforementioned concentrate and 30g Mel and is sufficiently mixed, stir.Drying, crushing：The spice of mix homogeneously is placed in into 60-70 DEG C of baking 4-5 hour in baking oven, is then crushed, cross 100 mesh sieves.Pelletize：The spice of mix homogeneously is inserted into pelletize in comminutor.Granulate：The granule for making is carried out into granulate, 35 mesh sieves are crossed.It is dried：Whole good granule is inserted in heat circulation drying oven, aeration-drying is to moisture ＜ 8% at 80 DEG C.Tabletting：Magnesium stearate mix homogeneously is added to be placed in tabletting in tablet machine dry mixed gained medicine（Also can coating）, per piece 0.5.Packaging：In first the tablet for pressing being fitted into into vial or vinyon bottle, then the bottle mounted box for installing, vanning, sterilizing (are adopted into 60Co irradiation, irradiation dose is 8kGy）.Finally, irradiated finished product is put in storage by the principle of first in first out.

Claims (2)

1. Hui ethnic group's Chinese medicine esophaguses hold back cancer piece and preparation method thereof, it is characterised in that it is by made by the raw material of following weight proportion：

Radix Sophorae Tonkinensiss 30g, neglect wood 20g, Rhizoma Dioscoreae Bulbiferae 7g, Fructus Mume 9g,

Semen Cuscutae 10g, Lentinus Edodess 9g, pellet feed 10g, Cortex Ailanthi 7g,

Rhizoma dioscoreae 20g, Radix Glycyrrhizae 7g, Mel 30g,

This side is the substantially square of one decoction on the one, in practical application, can also increase the 1-3 taste traditional Chinese medical science " harmony between man and nature, dialectical treatmert " theory according to the body constitution of patient and conditions“Dialectical compatibility " medicine.

2. the Hui ethnic group's Chinese medicine esophaguses according to claim 1 hold back the weight proportion of cancer piece, it is characterised in that including following preparation processes：

A, extract preparation

（1）, extract

A, for the first time extraction：By the weight of said herbal medicine in addition to Cortex Ailanthi, Radix Glycyrrhizae, all amplify 10 times, after clean water, be placed in BT-2 rustless steels and extract in kettle, plus after 7-9 times of tap water, be heated to 100 DEG C of constant temperature and extract 1 hour or so, extraction fluid, pressure filtration, filtrate is standby；

B, second extraction：Add in kettle the 5-7 times of tap water measured toward extracting, be heated to 100 DEG C of constant temperature and extract or so half an hour, extraction fluid, pressure filtration, filtrate is standby；

C, third time are extracted：Add in kettle the 3-5 times of tap water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes or so, extraction fluid, pressure filtration, filtrate is standby；

（2）, concentration

The extracting solution of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), be heated to 80 DEG C, be concentrated into relative density 1.10～1.20, it is standby；

（3）, powder processed

Cortex Ailanthi 7g, Radix Glycyrrhizae 7g are amplified into 10 times, it is end together to crush, cross 100 mesh sieves, it is standby；

（4）, dispensing

In 300,000 grades of dust proof workshops, above-mentioned medicated powder is put in mixer together with aforementioned concentrate and is sufficiently mixed, stir；

(5) drying, crushing

The spice of mix homogeneously is placed in into 60-70 DEG C of baking 4-5 hour in baking oven, is then crushed, cross 100 mesh sieves；

(6) pelletize

The spice of mix homogeneously is inserted into pelletize in comminutor；

(7) granulate

The granule for making is carried out into granulate, 35 mesh sieves are crossed；

(8) it is dried

Whole good granule is inserted in heat circulation drying oven, aeration-drying is to moisture ＜ 8% at 80 DEG C；

(9) tabletting

Magnesium stearate mix homogeneously is added to be placed in tabletting in tablet machine dry mixed gained medicine（Also can coating）, every 0.5g；

B, packaging

In first the tablet for pressing being fitted into into vial or vinyon bottle, then the bottle mounted box for installing, vanning, sterilizing (are adopted into 60Co irradiation, irradiation dose is 8kGy）；

C, warehouse-in

Irradiated finished product is put in storage by the principle of first in first out.