CN106667788A - Mask solution containing growth factors and dry mask - Google Patents
Mask solution containing growth factors and dry mask Download PDFInfo
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- CN106667788A CN106667788A CN201710070009.3A CN201710070009A CN106667788A CN 106667788 A CN106667788 A CN 106667788A CN 201710070009 A CN201710070009 A CN 201710070009A CN 106667788 A CN106667788 A CN 106667788A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention provides a mask solution containing growth factors. The mask solution is prepared from components in parts by weight as follows: 0.00001-0.0005 parts of growth factors, 0.1-2 parts of short peptide, 0.5-5 parts of chitosan, 0.5-5 parts of beta-glucan, 0.1-0.3 parts of allantoin, 0.5-5 parts of liquiritin, 1-5 parts of polyglycerine, 0.1-1 part of xanthan gum, 1-5 parts of glycerin, 2-6 parts of sorbitol, 2-6 parts of propylene glycol, 0.1-1 part of antibacterial peptides and 65-85 parts of water. The growth factors consist of epidermal growth factors and alkaline fibroblast growth factors in a weight ratio being (1-1.2): (1-1.2); the short peptide is histidine-seryl-tryptophan. The mask solution belongs to the technical field of cosmetics, has good skin moistening and conditioning effects and can have good moisturizing, moistening, anti-aging effects and the like.
Description
Technical field
The invention belongs to cosmetic technical field, more particularly to a kind of facial mask liquid containing growth factor and dry type facial mask.
Background technology
Due to natural aging and outside environmental elements, skin can gradually lose the protection work(of pollution and microorganism to external world
Can, the harm to surrounding is all the more sensitive, and skin adapts to the ability of environment worse and worse, causes dry skin, lax, allergy, dark
It is light, the skin problem such as lack flexibility.The skin of people was put into natural aging state from 20 years old or so, with the increase at age,
Sebum secretion amount is reduced, and water retaining capacity is reduced, and the moisture content barrier function of skin progressively fails, start to occur dry skin,
The problems such as elasticity is deteriorated and wrinkle increases.
Cosmetics species for alleviating or solving skin problem is various, and facial mask is due to quick result, fashion and experience
Sense it is stronger the characteristics of and liked by consumer.Effect of facial mask includes moisturizing, whitening, crease-resistant, moist etc..The effect of facial mask
Principle is to make facial skin be isolated from the outside a period of time, lifts epiderm skin temperature, strengthens face's top layer blood circulation, is promoted
Skin metabolism, the active component in facial mask gives the intensive nursing cares such as skin clean, moisturizing, whitening, so that skin becomes
Brighter and cleaner exquisiteness.
Growth factor is that class regulation cell normal growth metabolism institute is required, but can not voluntarily be closed with simple carbon and nitrogen sources
Into organic matter.Growth factor include it is various, such as platelet derived growth factor, EGF, TGF, into
Fibroblast growth factor, nerve growth factor and interleukins class growth factor etc..Growth factor without medicine class toxicity,
Immune response will not be caused, therefore with preferable security, obtained at aspects such as stem cell culture, immunological regulation, disease treatments
To being increasingly widely applied.EGF can promote the proliferation apoptosis of epidermal cell and endothelial cell etc., accelerate new old
Metabolism, repairs epidermis, promotes the synthesis of hyaluronic acid, collagenous fibres and glycoprotein etc., reaches the effect of skin care.Alkalescence into
Fibroblast growth factor can promote the migration of endothelial cell and the propagation of smooth muscle cell, promote cell to accelerate secretion collagen,
The endothelial cell for damaging is repaired, cell elasticity is maintained, the effect of deep layer reparation is reached.
Chinese patent application CN 105534734 discloses a kind of cosmetic composition preparation, including lactoferrin, vitamin
C, basic fibroblast growth factor and water, the content of basic fibroblast growth factor is 50~500 μ g/mL；The system
The component of agent is simple, can improve skin roughness, increases skin elasticity, and with preferable skin quality improvement result, but alkalescence is into fibre
The consumption of dimension Porcine HGF is higher, and long-time stability in the formulation are not ideal enough, easily with the prolongation of holding time
And gradually inactivate.
Although having contained the mask product listing of growth factor, existing mask product exist the consumption of growth factor compared with
It is high, the problems such as long-time stability are poor.
The content of the invention
To solve problems of the prior art, inventor provides a kind of facial mask liquid containing growth factor, by by table
Skin growth factor, basic fibroblast growth factor and small peptide (histidine-seryl-tryptophan) compounding use, on the one hand
The consumption of growth factor is reduced, the long-time stability of growth factor are enhanced, skin moisturizing is on the other hand further enhancing
And conditioning effect, reach good moisturizing, moist, anti-aging and other effects.
The purpose of the present invention will be further described in detail below reflect and description.
The present invention provides a kind of facial mask liquid containing growth factor, including following component and its parts by weight：Growth factor
0.00001~0.0005 part, 0.1~2 part of small peptide, 0.5~5 part of shitosan, 0.5~5 part of beta glucan, allantoin 0.1~0.3
Part, 0.5~5 part of liquiritin, 1~5 part of Natrulon H-10,0.1~1 part of xanthans, 1~5 part of glycerine, 2~6 parts of sorbierite, third
2~6 parts of glycol, 0.1~1 part of antibacterial peptide, 65~85 parts of water；The growth factor is thin by EGF and basic fibroblast
The intracellular growth factor is with 1~1.2：1~1.2 weight is than composition；The small peptide is histidine-seryl-tryptophan.
Using above-mentioned technical proposal, by the collaboration of EGF, basic fibroblast growth factor and small peptide
Synergistic effect, can promote the metabolism of the various cells of skin, strengthen the absorption of nutriment, promote collagen and clostridiopetidase A to close
Into secretion Collagen material, hyaluronic acid and glycoprotein adjust collagenous fibres, play deep layer and moisten, strengthen skin elasticity, reduce
The effect of wrinkle and anti-aging.Conditioning skin can be played by adding liquiritin, antiallergy reduces the irritating effect of system.
Although common amino acid has more than 20 clocks, the connection between amino acid is ever-changing, and different peptide chain structures is past
Toward with different function and activity.Inventor be found by experiment that histidine-seryl-tryptophan have good moisturizing,
Effect of antibacterial, Green Tea Extract and anti-aging, and then histidine-seryl-tryptophan is used for into the preparation of facial mask liquid, achieve
Strengthen the long-time stability of growth factor, strengthen moisturizing, the moist, effect of anti-aging.
Preferably, the described facial mask liquid containing growth factor, including following component and its parts by weight：EGF
0.00005~0.0002 part, 0.00005~0.0002 part of basic fibroblast growth factor, 0.5~1 part of small peptide, shitosan
1~3 part, 1~4 part of beta glucan, 0.2~0.3 part of allantoin, 1~4 part of liquiritin, 1~4 part of Natrulon H-10, xanthans
0.5~1 part, 2~4 parts of glycerine, 2~5 parts of sorbierite, 2~5 parts of propane diols, 0.1~1 part of antibacterial peptide, 70~82 parts of water.
It is highly preferred that the described facial mask liquid containing growth factor, including following component and its parts by weight：Epidermal growth factor
0.0001 part of son, 0.0001 part of basic fibroblast growth factor, 1.2 parts of small peptide, 2 parts of shitosan, beta glucan 3, allantois
0.3 part of element, 3 parts of liquiritin, 3 parts of Natrulon H-10,1 part of xanthans, 4 parts of glycerine, 3 parts of sorbierite, 4 parts of propane diols, antibacterial peptide
0.5 part, 75 parts of water.
Preferably, the described facial mask liquid containing growth factor, also including 0.01~0.1 part of essence and/or chelating agent 0.1~
1 part.
Preferably, the antibacterial peptide is selected from house fly antibiotic peptide or antibacterial peptide DC.Antibacterial peptide DC can refer to patent
200510032743.8 in method prepare, the activity of antibacterial peptide DC is 5000IU/mL.
Correspondingly, the present invention also provides the preparation method of the facial mask liquid containing growth factor, comprises the steps：
S1 weigh shitosan, glycerine, sorbierite, propane diols, allantoin, liquiritin, Natrulon H-10, xanthans and water in
In reactor, 3~10min of homogeneous is stirred, and be heated to 70~85 DEG C, obtain material A, be cooled to 50~65 DEG C, it is standby；
S2 adds beta glucan and antibacterial peptide in the material A, stirs homogeneous, obtains material B, is cooled to 35~45
DEG C, it is standby；
S3 adds EGF, basic fibroblast growth factor and small peptide in the material B, stirs homogeneous
3~10min, obtains the facial mask liquid containing growth factor.
Preferably, step S3 also includes adding essence and/or chelating agent.
Additionally, the present invention also provides a kind of dry type facial mask, including the described facial mask liquid containing growth factor and dry type facial mask
Carrier.
Correspondingly, the present invention also provides the preparation method of described dry type facial mask, comprises the steps：Dry type facial mask is carried
Body is placed on flat board, adds the facial mask liquid containing growth factor to be impregnated with, and is dried at 50~70 DEG C, obtains dry type facial mask.
Preferably, the dry type mask carriers are non-woven fabrics.
Compared with prior art, the invention has the beneficial effects as follows：The facial mask liquid containing growth factor that inventor provides, passes through
By EGF, basic fibroblast growth factor and small peptide (histidine-seryl-tryptophan) compounding use, one
Aspect reduces the consumption of growth factor, enhances the long-time stability of growth factor, on the other hand further enhancing skin
Moisten and conditioning effect, reach good moisturizing, moist, anti-aging and other effects.The present invention also provides a kind of dry type facial mask, not only
There is weight saving, convenient transportation, extended shelf-life, moreover it is possible to maintain the steady in a long-term of active component.
Specific embodiment
Below by specific embodiment, the present invention is described in further detail.
In the present invention, involved component and raw material is conventional commercial product, or can pass through the ordinary skill in the art
Means are obtained.
Facial mask liquid of the embodiment one containing growth factor
Facial mask liquid containing growth factor, including following component and its parts by weight：0.0001 part of EGF, alkalescence
0.0001 part of fibroblast growth factor, 1.2 parts of small peptide, 2 parts of shitosan, beta glucan 3,0.3 part of allantoin, liquiritin 3
Part, 3 parts of Natrulon H-10,1 part of xanthans, 4 parts of glycerine, 3 parts of sorbierite, 4 parts of propane diols, 0.5 part of antibacterial peptide DC, 75 parts of water.
The small peptide is histidine-seryl-tryptophan.
Preparation method comprises the steps：
S1 weigh shitosan, glycerine, sorbierite, propane diols, allantoin, liquiritin, Natrulon H-10, xanthans and water in
In reactor, homogeneous 5min is stirred, and be heated to 75 DEG C, obtain material A, be cooled to 55 DEG C, it is standby；
S2 adds beta glucan and antibacterial peptide DC in the material A, stirs homogeneous, obtains material B, is cooled to 40 DEG C,
It is standby；
S3 adds EGF, basic fibroblast growth factor and small peptide in the material B, stirs homogeneous
Homogeneous 5min, obtains the facial mask liquid containing growth factor.
Using method：Facial mask liquid Direct Uniform can be applied in face, also can obtain facial mask Jing after non-woven fabrics immersion and dab
Use, clean after 10~20min.
Facial mask liquid of the embodiment two containing growth factor
Facial mask liquid containing growth factor, including following component and its parts by weight：0.00008 part of EGF, alkali
0.00012 part of fibroblast growth factor of property, 1.3 parts of small peptide, 1 part of shitosan, beta glucan 3,0.2 part of allantoin, Radix Glycyrrhizae
2 parts of glycosides, 4 parts of Natrulon H-10,1 part of xanthans, 3 parts of glycerine, 4 parts of sorbierite, 2 parts of propane diols, 0.5 part of antibacterial peptide DC, water 78
Part.The small peptide is histidine-seryl-tryptophan.
Preparation method is with embodiment one.
Facial mask liquid of the embodiment three containing growth factor
Facial mask liquid containing growth factor, including following component and its parts by weight：0.00012 part of EGF, alkali
0.00008 part of fibroblast growth factor of property, 2 parts of small peptide, 3 parts of shitosan, beta glucan 2,0.3 part of allantoin, liquiritin 4
Part, 3 parts of Natrulon H-10,1 part of xanthans, 2 parts of glycerine, 2 parts of sorbierite, 4 parts of propane diols, 0.7 part of antibacterial peptide DC, 76 parts of water.
The small peptide is histidine-seryl-tryptophan.
Preparation method is with embodiment one.
Comparative example 1
Facial mask liquid, including following component and its parts by weight：0.0001 part of EGF, basic fibroblast life
0.0001 part of the long factor, 2 parts of shitosan, beta glucan 3,0.3 part of allantoin, 3 parts of liquiritin, 3 parts of Natrulon H-10, xanthans
1 part, 4 parts of glycerine, 3 parts of sorbierite, 4 parts of propane diols, 0.5 part of antibacterial peptide DC, 75 parts of water.
Comparative example 1 is with the difference of embodiment one：Without small peptide histidine-seryl-tryptophan.
Comparative example 2
Facial mask liquid, including following component and its parts by weight：0.0001 part of EGF, basic fibroblast life
0.0001 part of the long factor, 1.2 parts of small peptide, 2 parts of shitosan, beta glucan 3,0.3 part of allantoin, 3 parts of liquiritin, Natrulon H-10 3
Part, 1 part of xanthans, 4 parts of glycerine, 3 parts of sorbierite, 4 parts of propane diols, 0.5 part of antibacterial peptide DC, 75 parts of water.The small peptide is sweet ammonia
Acyl-histidyl--lysine.
Comparative example 2 is with the difference of embodiment one：Small peptide is changed to glycyl-group ammonia by histidine-seryl-tryptophan
Acyl-lysine.
The facial mask liquid of comparative example 3
Facial mask liquid, including following component and its parts by weight：1.2 parts of small peptide, 2 parts of shitosan, beta glucan 3, allantoin
0.3 part, 3 parts of liquiritin, 3 parts of Natrulon H-10,1 part of xanthans, 4 parts of glycerine, 3 parts of sorbierite, 4 parts of propane diols, antibacterial peptide DC
0.5 part, 75 parts of water.The small peptide is histidine-seryl-tryptophan.
Comparative example 3 is with the difference of embodiment one：Without EGF and basic fibroblast growth factor.
The safety testing of test example one
2015 editions issued with reference to the Ministry of Public Health《Cosmetics health specification》In " human skin patch " related request
The embodiment of the present invention one to embodiment three, comparative example 1 are tested to the facial mask liquid of comparative example 3 with assay method, is existed respectively
0h, 6h, 12h, 24h, 48h observe dermoreaction, and the experimental result of all volunteers on probation is negative findings, skin do not occur
Bad reaction.The facial mask liquid containing growth factor that the present invention is provided is nonirritant, and security is good.
Example IV dry type facial mask
Dry type facial mask, including the facial mask liquid and dry type mask carriers of embodiment one, dry type mask carriers are non-woven fabrics.
The preparation method of dry type facial mask, comprises the steps：Dry type mask carriers are placed on flat board, embodiment one is added
Facial mask liquid be impregnated with (every square centimeter dry type mask carriers spray 0.08g facial mask liquids), be dried at 60 DEG C, obtain dry type facial mask.
Using method：Packaging bag one end of dry type facial mask is opened, water 20g is added, facial mask is taken out after immersion 10min, gently
Apply and use, clean after 10~20min.
The skin moisture content of test example two and elastomeric check
Face is selected to have the aging performance of mild skin (phenomenon such as drying, microgroove, flexibility decrease and wrinkle) and without cosmetics
The women of the allergies people of volunteer 180 on probation, the age, at 30~51 years old, meets into a group condition, and the principle by parallel control is random
It is divided into one group of embodiment, 1 group of comparative example, 2 groups of comparative example, 3 groups of comparative example, positive controls, group 1, group 2, group 3 and group 4, per group
20 people, the average moisture content and elasticity number of each group do not have significant difference before on probation.One group of embodiment uses embodiment
Facial mask obtained in one facial mask liquid, organizes facial mask obtained in 1 facial mask liquid for using the embodiment one for preserving 2 years, and 1 group of comparative example is used
Facial mask obtained in the facial mask liquid of comparative example 1, organizes facial mask obtained in 2 facial mask liquids for using the comparative example 1 for preserving 2 years, 2 groups of comparative example
Using comparative example 2 facial mask liquid obtained in facial mask, group 3 using preserve 2 years comparative examples 2 facial mask liquids obtained in facial mask, it is right
Facial mask obtained in 3 groups of facial mask liquids using comparative example 3 of ratio, group 4 is used obtained in the facial mask liquid of the comparative example 3 for preserving 2 years
Facial mask, positive controls once a day, one are pasted every time using the elite sodium hyaluronate moisture saver mask of commercially available famous brand name, and application is advanced
Row facial cleansing, the application time is 15min.Try out after 10d and 20d, respectively skin water is carried out to volunteer on probation
Divide content and elastomeric check, detection time is that facial mask application is completed after 20min, calculates skin of face moisture and elastic change
Rate, as a result as shown in Table 1 and Table 2.
Moisture detection is detected using Fes Kai Er SK-III skin moistures detector, takes 5 points and measure and be averaged
Value.The skin elasticity Cotometer that elastomeric check is manufactured using Courage+Khazaka companies of Germany (German CK companies)
MPA580 main frames, the probe for being used is Reviscometer RV600 elastic fibrous tissues test probe, takes 5 points and measures simultaneously
Average.
Table 1 uses the skin moisture content change table after different facial masks
As known from Table 1, facial mask obtained in the facial mask liquid that the present invention is provided has good moisturizing effect, using skin after 20d
Skin average moisture content increases by 31.3%.By contrast, it can be found that：1 group of comparative example, 2 groups of comparative example and positive controls
Average moisture incrementss are slightly less than one group of embodiment, but difference is less, and skin average moisture increases after 3 groups of comparative example 20d on probation
Dosage is only 19.6%, illustrates that EGF and basic fibroblast growth factor are played to improving skin moisture content
Important function.Group 1 increases by 29.6% using skin average moisture content after 20d, little with one group of difference of embodiment, illustrates face
Obtained facial mask still has good moisturizing effect, the good stability of active component after film liquid is preserved 2 years；3 groups of group 4 and comparative example
Compare, the difference of average moisture incrementss less, illustrates the active component good stability beyond growth factor in facial mask liquid；And group
2 average moisture incrementss are significantly lower than 2 groups of comparative example, and the average moisture incrementss of group 3 are significantly lower than 3 groups of comparative example, can
See, the long-time stability of the active component in the case where histidine-seryl-tryptophan is not contained in facial mask liquid are not ideal enough,
Histidine-seryl-tryptophan has important function for the stability for improving active component in facial mask liquid.
Table 2 uses the skin elasticity change table after different facial masks
As known from Table 2, facial mask obtained in the facial mask liquid that the present invention is provided has good increase skin elasticity effect, uses
Skin elasticity increases by 38.34% after 20d.By contrast, it can be found that：1 group of comparative example, 2 groups of comparative example and positive controls
Average moisture incrementss are slightly less than one group of embodiment, but difference is less, and skin elasticity incrementss after 3 groups of comparative example 20d on probation
Only 20.47%, illustrate that EGF and basic fibroblast growth factor play important work to increasing skin elasticity
With.Group 1 increases by 35.82% using skin average moisture content after 20d, little with one group of difference of embodiment, illustrates facial mask liquid
Obtained facial mask still has good increase skin elasticity effect, the good stability of active component after preserving 2 years；Group 4 and contrast
3 groups of example is compared, and the difference of skin elasticity incrementss less, illustrates the active component stability beyond growth factor in facial mask liquid
It is good；And the skin elasticity incrementss of group 2 are significantly lower than 2 groups of comparative example, and the skin elasticity incrementss of group 3 are significantly lower than comparative example
3 groups, it is seen then that the long-time stability of the active component in the case where histidine-seryl-tryptophan is not contained in facial mask liquid are not
Good, histidine-seryl-tryptophan has important function for the stability for improving active component in facial mask liquid.Moisture of skin
Increase and skin elasticity increase is more, then anti-aging effects are better.
Additionally, collecting volunteer on probation after 20d on probation in skin elasticity, wrinkle reduction, skin water moisture feeling, skin light
The evaluation marking of the aspects such as pool, application comfort level, bad reaction, full marks are 100 points, as a result as shown in table 3.
Table 3 tries out the evaluation marking that volunteer tries out facial mask obtained in facial mask liquid of the present invention
| Group | Average |
| One group of embodiment | 91 |
| 1 group of comparative example | 82 |
| 2 groups of comparative example | 87 |
| 3 groups of comparative example | 74 |
| Positive controls | 83 |
As known from Table 3, the combination property of facial mask is good obtained in the facial mask liquid that the present invention is provided, by trying out volunteer's
Welcome.
Above content is to combine specific preferred embodiment further description made for the present invention, it is impossible to assert
The present invention be embodied as be confined to these explanations.For general technical staff of the technical field of the invention,
On the premise of without departing from present inventive concept, some simple deduction or replace can also be made, should all be considered as belonging to the present invention's
Protection domain.
Claims (10)
1. a kind of facial mask liquid containing growth factor, it is characterised in that：Including following component and its parts by weight：Growth factor
0.00001~0.0005 part, 0.1~2 part of small peptide, 0.5~5 part of shitosan, 0.5~5 part of beta glucan, allantoin 0.1~0.3
Part, 0.5~5 part of liquiritin, 1~5 part of Natrulon H-10,0.1~1 part of xanthans, 1~5 part of glycerine, 2~6 parts of sorbierite, third
2~6 parts of glycol, 0.1~1 part of antibacterial peptide, 65~85 parts of water；The growth factor is thin by EGF and basic fibroblast
The intracellular growth factor is with 1~1.2：1~1.2 weight is than composition；The small peptide is histidine-seryl-tryptophan.
2. the facial mask liquid containing growth factor according to claim 1, it is characterised in that：Including following component and its weight portion
Number：0.00005~0.0002 part of EGF, 0.00005~0.0002 part of basic fibroblast growth factor, small peptide
0.5~2 part, 1~3 part of shitosan, 1~4 part of beta glucan, 0.2~0.3 part of allantoin, 1~4 part of liquiritin, Natrulon H-10
1~4 part, 0.5~1 part of xanthans, 2~4 parts of glycerine, 2~5 parts of sorbierite, 2~5 parts of propane diols, 0.1~1 part of antibacterial peptide, water
70~82 parts.
3. the facial mask liquid containing growth factor according to claim 2, it is characterised in that：Including following component and its weight portion
Number：0.0001 part of EGF, 0.0001 part of basic fibroblast growth factor, 1.2 parts of small peptide, 2 parts of shitosan, β-
Glucan 3,0.3 part of allantoin, 3 parts of liquiritin, 3 parts of Natrulon H-10,1 part of xanthans, 4 parts of glycerine, 3 parts of sorbierite, the third two
4 parts of alcohol, 0.5 part of antibacterial peptide, 75 parts of water.
4. the facial mask liquid containing growth factor according to any one of claim 1 to 3, it is characterised in that：Also include essence
0.01~0.1 part and/or 0.1~1 part of chelating agent.
5. the facial mask liquid containing growth factor according to any one of claim 1 to 3, it is characterised in that：The antibacterial peptide
Selected from house fly antibiotic peptide or antibacterial peptide DC.
6. the preparation method of the facial mask liquid containing growth factor according to claim 1, it is characterised in that：Including following step
Suddenly：
S1 weighs shitosan, glycerine, sorbierite, propane diols, allantoin, liquiritin, Natrulon H-10, xanthans and water in reaction
In device, 3~10min of homogeneous is stirred, and be heated to 70~85 DEG C, obtain material A, be cooled to 50~65 DEG C, it is standby；
S2 adds beta glucan and antibacterial peptide in the material A, stirs homogeneous, obtains material B, is cooled to 35~45 DEG C, standby
With；
S3 adds EGF, basic fibroblast growth factor and small peptide in the material B, and stirring homogeneous 3~
10min, obtains the facial mask liquid containing growth factor.
7. the preparation method of the facial mask liquid containing growth factor according to claim 6, it is characterised in that：Step S3 is also
Including addition essence and/or chelating agent.
8. a kind of dry type facial mask, it is characterised in that：Including the facial mask containing growth factor any one of claim 1 to 7
Liquid and dry type mask carriers.
9. the preparation method of dry type facial mask according to claim 8, it is characterised in that：Comprise the steps：By dry type face
Membrane carrier is placed on flat board, adds the facial mask liquid containing growth factor to be impregnated with, and is dried at 50~70 DEG C, obtains dry type facial mask.
10. the preparation method of dry type facial mask according to claim 9, it is characterised in that：The dry type mask carriers are nothing
Spin cloth.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201710070009.3A CN106667788A (en) | 2017-02-08 | 2017-02-08 | Mask solution containing growth factors and dry mask |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710070009.3A CN106667788A (en) | 2017-02-08 | 2017-02-08 | Mask solution containing growth factors and dry mask |
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| CN106667788A true CN106667788A (en) | 2017-05-17 |
Family
ID=58860269
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710070009.3A Pending CN106667788A (en) | 2017-02-08 | 2017-02-08 | Mask solution containing growth factors and dry mask |
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| CN107320347A (en) * | 2017-08-21 | 2017-11-07 | 北京日蒙生物科技有限公司 | A kind of application of electrolytic reduction water in dry type facial mask |
| CN107519034A (en) * | 2017-08-17 | 2017-12-29 | 成都新柯力化工科技有限公司 | A kind of skin deep layer of the bioactie agent containing chelating repairs liquid and preparation method thereof |
| CN108379197A (en) * | 2018-05-14 | 2018-08-10 | 杨森 | A kind of skin barrier repairs moisture saver mask and preparation method thereof |
| CN108618994A (en) * | 2018-07-20 | 2018-10-09 | 东华大学 | A kind of separating dry space from moist space facial mask and its preparation and application |
| CN110946821A (en) * | 2019-11-29 | 2020-04-03 | 上海长一干细胞研究中心有限公司 | High-moisturizing skin-moistening and reconstructing children deciduous tooth pulp stem cell mask |
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| CN107519034A (en) * | 2017-08-17 | 2017-12-29 | 成都新柯力化工科技有限公司 | A kind of skin deep layer of the bioactie agent containing chelating repairs liquid and preparation method thereof |
| CN107320347A (en) * | 2017-08-21 | 2017-11-07 | 北京日蒙生物科技有限公司 | A kind of application of electrolytic reduction water in dry type facial mask |
| CN108379197A (en) * | 2018-05-14 | 2018-08-10 | 杨森 | A kind of skin barrier repairs moisture saver mask and preparation method thereof |
| CN108618994A (en) * | 2018-07-20 | 2018-10-09 | 东华大学 | A kind of separating dry space from moist space facial mask and its preparation and application |
| CN110946821A (en) * | 2019-11-29 | 2020-04-03 | 上海长一干细胞研究中心有限公司 | High-moisturizing skin-moistening and reconstructing children deciduous tooth pulp stem cell mask |
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