CN106661065B - 环状膦酸钠盐的晶体及其制造方法 - Google Patents

环状膦酸钠盐的晶体及其制造方法 Download PDF

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CN106661065B
CN106661065B CN201580043025.2A CN201580043025A CN106661065B CN 106661065 B CN106661065 B CN 106661065B CN 201580043025 A CN201580043025 A CN 201580043025A CN 106661065 B CN106661065 B CN 106661065B
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CN106661065A (zh
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汤浅宏昭
冈崎宏纪
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Otsuka Chemical Co Ltd
Sansho Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65748—Esters of oxyacids of phosphorus the cyclic phosphorus atom belonging to more than one ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
CN201580043025.2A 2014-08-12 2015-08-12 环状膦酸钠盐的晶体及其制造方法 Active CN106661065B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2014164423 2014-08-12
JP2014-164423 2014-08-12
PCT/JP2015/072825 WO2016024605A1 (fr) 2014-08-12 2015-08-12 Cristal de sel de sodium d'acide phosphonique cyclique et son procédé de fabrication

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CN106661065A CN106661065A (zh) 2017-05-10
CN106661065B true CN106661065B (zh) 2021-09-24

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US (5) US9908909B2 (fr)
EP (3) EP3492479A3 (fr)
JP (2) JP6736466B2 (fr)
KR (1) KR102563800B1 (fr)
CN (1) CN106661065B (fr)
ES (2) ES2884041T3 (fr)
TW (5) TWI710567B (fr)
WO (1) WO2016024605A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016024605A1 (fr) * 2014-08-12 2016-02-18 大塚化学株式会社 Cristal de sel de sodium d'acide phosphonique cyclique et son procédé de fabrication
JPWO2021132297A1 (fr) 2019-12-23 2021-07-01
CN116710105A (zh) 2020-11-26 2023-09-05 山椒株式会社 肺纤维化治疗剂

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1402894A1 (fr) * 2001-05-21 2004-03-31 Gencom Corporation Inhibiteurs de metastases cancereuses contenant des derives d'acide phosphatidique carbacycliques
EP1535926A1 (fr) * 2002-06-11 2005-06-01 Kimiko Murofushi Derive d'acide phosphatidique carbacyclique
CN103906519A (zh) * 2011-11-11 2014-07-02 山椒株式会社 关节病治疗剂

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
JPS5430517B2 (fr) 1973-11-15 1979-10-01
JPH06228169A (ja) * 1993-02-05 1994-08-16 Sagami Chem Res Center １−ｏ−アシルグリセロール２，３−ホスフェートの製造法
US20090326256A1 (en) 2006-12-28 2009-12-31 Ochanomizu University Analgesic agent comprising cyclic phosphatidic acid derivative
DE102007032669A1 (de) 2007-07-13 2009-01-15 Clariant International Limited Alkylphosphonigsäuren, -salze und -ester, Verfahren zu deren Herstellung und ihre Verwendung
CN101143880B (zh) * 2007-10-17 2012-08-22 中山大学 膦异香豆素盐及其制备方法
WO2011065480A1 (fr) * 2009-11-26 2011-06-03 国立大学法人お茶の水女子大学 Inhibiteur de l'apoptose des cellules nerveuses
ES2710891T3 (es) * 2011-12-06 2019-04-29 Ivoclar Vivadent Ag Materiales dentales a base de ácidos bisfosfónicos polimerizables fuertemente ácidos
WO2016024605A1 (fr) * 2014-08-12 2016-02-18 大塚化学株式会社 Cristal de sel de sodium d'acide phosphonique cyclique et son procédé de fabrication

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1402894A1 (fr) * 2001-05-21 2004-03-31 Gencom Corporation Inhibiteurs de metastases cancereuses contenant des derives d'acide phosphatidique carbacycliques
EP1535926A1 (fr) * 2002-06-11 2005-06-01 Kimiko Murofushi Derive d'acide phosphatidique carbacyclique
CN103906519A (zh) * 2011-11-11 2014-07-02 山椒株式会社 关节病治疗剂

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"Inhibition of transcellular tumor cell migration and metastasis by novel carba-derivatives of cyclic phosphatidic acid";Ayako Uchiyama et al.;《Biochimica et Biophysica Acta》;20061014;第1771卷;第103-112页 *
Ayako Uchiyama et al.."Inhibition of transcellular tumor cell migration and metastasis by novel carba-derivatives of cyclic phosphatidic acid".《Biochimica et Biophysica Acta》.2006,第1771卷第103-112页. *
Emi Nozaki et al.."Pharmacological evaluation of a novel cyclic phosphatidic acid derivative 3-S-cyclic phosphatidic acid (3-S-cPA)".《Bioorganic & Medicinal Chemistry》.2012,第20卷第3196-3201页. *
Emi Nozaki et al.."Synthesis of enantiopure 2-carba-cyclic phosphatidic acid and effects of its chirality on biological functions".《Biochimica et Biophysica Acta》.2011,第1811卷第271-277页. *
Renuka Gupte et al.."Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid".《Bioorganic & Medicinal Chemistry Letters》.2010,第20卷第7525-7528页. *

Also Published As

Publication number Publication date
TWI710567B (zh) 2020-11-21
TWI758777B (zh) 2022-03-21
US20200277317A1 (en) 2020-09-03
US20170233421A1 (en) 2017-08-17
CN106661065A (zh) 2017-05-10
JPWO2016024605A1 (ja) 2017-05-25
EP3483169B1 (fr) 2021-05-26
US10385081B2 (en) 2019-08-20
US10774100B2 (en) 2020-09-15
TW201934567A (zh) 2019-09-01
KR102563800B1 (ko) 2023-08-03
JP6736466B2 (ja) 2020-08-05
US20180208614A1 (en) 2018-07-26
JP2020109131A (ja) 2020-07-16
US20200277318A1 (en) 2020-09-03
US10941169B2 (en) 2021-03-09
US11168101B2 (en) 2021-11-09
TWI672313B (zh) 2019-09-21
TW202039520A (zh) 2020-11-01
US9908909B2 (en) 2018-03-06
TW201613944A (en) 2016-04-16
ES2804710T3 (es) 2021-02-09
TWI759790B (zh) 2022-04-01
US20190330251A1 (en) 2019-10-31
EP3492479A2 (fr) 2019-06-05
EP3181573B1 (fr) 2020-06-17
EP3492479A3 (fr) 2019-10-02
EP3483169A1 (fr) 2019-05-15
EP3181573A4 (fr) 2018-04-18
ES2884041T3 (es) 2021-12-10
TWI733108B (zh) 2021-07-11
WO2016024605A1 (fr) 2016-02-18
TW202039521A (zh) 2020-11-01
EP3181573A1 (fr) 2017-06-21
KR20170042653A (ko) 2017-04-19
TW201934566A (zh) 2019-09-01

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Address after: Osaka, Japan

Patentee after: OTSUKA CHEMICAL Co.,Ltd.

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