CN106659795B - 脂质体莫匹罗星 - Google Patents

脂质体莫匹罗星 Download PDF

Info

Publication number
CN106659795B
CN106659795B CN201580019117.7A CN201580019117A CN106659795B CN 106659795 B CN106659795 B CN 106659795B CN 201580019117 A CN201580019117 A CN 201580019117A CN 106659795 B CN106659795 B CN 106659795B
Authority
CN
China
Prior art keywords
liposomes
liposome
mupirocin
hpcd
loading
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201580019117.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN106659795A (zh
Inventor
伊齐基尔·巴伦霍兹
阿米拉姆·戈德布卢姆
阿胡瓦·瑟恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Publication of CN106659795A publication Critical patent/CN106659795A/zh
Application granted granted Critical
Publication of CN106659795B publication Critical patent/CN106659795B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201580019117.7A 2014-04-10 2015-04-08 脂质体莫匹罗星 Active CN106659795B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461977731P 2014-04-10 2014-04-10
US61/977,731 2014-04-10
PCT/IL2015/050376 WO2015155773A1 (en) 2014-04-10 2015-04-08 Liposomal mupirocin

Publications (2)

Publication Number Publication Date
CN106659795A CN106659795A (zh) 2017-05-10
CN106659795B true CN106659795B (zh) 2023-06-02

Family

ID=53177332

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580019117.7A Active CN106659795B (zh) 2014-04-10 2015-04-08 脂质体莫匹罗星

Country Status (6)

Country Link
US (1) US10004688B2 (enExample)
EP (1) EP3142642B1 (enExample)
JP (1) JP6676035B2 (enExample)
CN (1) CN106659795B (enExample)
DK (1) DK3142642T3 (enExample)
WO (1) WO2015155773A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI754659B (zh) * 2016-08-08 2022-02-11 台灣微脂體股份有限公司 用於製備含有弱酸性劑之微脂體組合物的傳輸載體、方法及套組
EP3520819A1 (en) * 2018-01-31 2019-08-07 Universität Basel Shear stress sensitive liposomes
CN114727960A (zh) * 2019-10-03 2022-07-08 耶路撒冷希伯来大学伊森姆研究发展有限公司 数个脂质体大麻素及其用途
EP4125809A1 (en) * 2020-03-25 2023-02-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Liposomal formulations comprising at1 receptor blockers and uses thereof
CN116270433B (zh) * 2023-03-14 2023-09-01 郑州大学第一附属医院 一种莫匹罗星软膏、制备方法及用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103501766A (zh) * 2011-03-01 2014-01-08 to-BBB控股股份有限公司 不良水溶性物质的高主动脂质体装载

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995015746A1 (en) * 1993-12-10 1995-06-15 The School Of Pharmacy Liposome delivery systems
EP0825852B1 (en) * 1995-04-18 2004-07-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposome drug-loading method and composition
CA2584583A1 (en) * 2004-10-28 2006-05-11 Alza Corporation Lyophilized liposome formulations and method
WO2007005754A2 (en) 2005-07-01 2007-01-11 Alza Corporation Liposomal delivery vehicle for hydrophobic drugs
WO2007044745A1 (en) * 2005-10-11 2007-04-19 Biosynexus Incorporated Lantibiotic and mupirocin compositions for treating bacterial infections
US20090196918A1 (en) * 2008-02-01 2009-08-06 University Of Kentucky Research Foundation Liposomal formulations of hydrophobic lactone drugs in the presence of metal ions
JP5785175B2 (ja) * 2009-10-26 2015-09-24 石葯集団中奇制葯技▲術▼（石家庄）有限公司 スルホブチルエーテルシクロデキストリン塩を含有する内水相を有するリポソーム

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103501766A (zh) * 2011-03-01 2014-01-08 to-BBB控股股份有限公司 不良水溶性物质的高主动脂质体装载

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Effect of Solubilizing Agents on Mupirocin Loading into and Release from PEGylated Nanoliposomes;Ahuva Cern等;《Journal of Pharmaceutical Sciences》;20140604;第103卷;第2131–2138页 *

Also Published As

Publication number Publication date
DK3142642T3 (en) 2018-12-17
JP6676035B2 (ja) 2020-04-08
CN106659795A (zh) 2017-05-10
US20170027869A1 (en) 2017-02-02
US10004688B2 (en) 2018-06-26
EP3142642B1 (en) 2018-08-29
WO2015155773A1 (en) 2015-10-15
JP2017513938A (ja) 2017-06-01
EP3142642A1 (en) 2017-03-22

Similar Documents

Publication Publication Date Title
US11173178B2 (en) Liposomes for drug delivery and methods for preparation thereof
JP5770336B2 (ja) リポソーム組成物の製造方法
DE60122304T2 (de) Auf lipiden basierendes system zur zielgerichteten verabreichung diagnostischer wirkstoffe
CN103479578B (zh) 一种马来酸匹杉琼的脂质体制剂及其制备工艺
US20190328665A1 (en) Liposome compositions encapsulating modified cyclodextrin complexes and uses thereof
US10004688B2 (en) Liposomal mupirocin
WO2017066726A1 (en) Stabilizing camptothecin pharmaceutical compositions
US20260130856A1 (en) Liposome compositions for delivery of compounds and methods thereof
WO2011032563A1 (en) Medical use of spla2 hydrolysable liposomes
Li et al. Encapsulation of mitoxantrone into pegylated SUVs enhances its antineoplastic efficacy
R Naik et al. Liposomes as potential carrier system for targeted delivery of polyene antibiotics
US8241663B2 (en) Liposome preparation
Cui et al. Development of pegylated liposomal vincristine using novel sulfobutyl ether cyclodextrin gradient: Is improved drug retention sufficient to surpass DSPE–PEG‐induced drug leakage?
CN1980671A (zh) 含有水难溶性喜树碱的脂质体制剂
US20230129331A1 (en) Liposomal formulations comprising at1 receptor blockers and uses thereof
Fung Pharmacokinetic characterization of tumor influx and efflux of liposomes by rapid removal of circulating liposomes

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant