CN106659763A - 使用nmda调节剂治疗抑郁症的方法 - Google Patents

使用nmda调节剂治疗抑郁症的方法 Download PDF

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Publication number
CN106659763A
CN106659763A CN201580043626.3A CN201580043626A CN106659763A CN 106659763 A CN106659763 A CN 106659763A CN 201580043626 A CN201580043626 A CN 201580043626A CN 106659763 A CN106659763 A CN 106659763A
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CN
China
Prior art keywords
patient
weeks
depression
glyx
period
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580043626.3A
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English (en)
Chinese (zh)
Inventor
R·伯奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Naurex Inc
Original Assignee
Naurex Inc
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Filing date
Publication date
Application filed by Naurex Inc filed Critical Naurex Inc
Publication of CN106659763A publication Critical patent/CN106659763A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
CN201580043626.3A 2014-08-14 2015-08-13 使用nmda调节剂治疗抑郁症的方法 Pending CN106659763A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462037374P 2014-08-14 2014-08-14
US62/037,374 2014-08-14
PCT/US2015/045071 WO2016025721A1 (en) 2014-08-14 2015-08-13 Methods of treating depression using nmda modulators

Publications (1)

Publication Number Publication Date
CN106659763A true CN106659763A (zh) 2017-05-10

Family

ID=55304631

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580043626.3A Pending CN106659763A (zh) 2014-08-14 2015-08-13 使用nmda调节剂治疗抑郁症的方法

Country Status (18)

Country Link
US (1) US20170296616A1 (https=)
EP (1) EP3180015A4 (https=)
JP (2) JP2017524721A (https=)
KR (1) KR20170040351A (https=)
CN (1) CN106659763A (https=)
AU (2) AU2015301650A1 (https=)
BR (1) BR112017002930A2 (https=)
CA (1) CA2957937A1 (https=)
CL (1) CL2017000378A1 (https=)
CO (1) CO2017002356A2 (https=)
IL (1) IL250557A0 (https=)
MX (1) MX2017002052A (https=)
PH (1) PH12017500275A1 (https=)
RU (1) RU2017107033A (https=)
SG (2) SG11201701134XA (https=)
UA (1) UA123623C2 (https=)
WO (1) WO2016025721A1 (https=)
ZA (1) ZA201701526B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111670041A (zh) * 2017-12-05 2020-09-15 诺雷克斯股份有限公司 用在组合疗法(睡眠障碍或中枢神经系统障碍)中的nmda受体调节剂(拉帕斯汀)组合

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018530593A (ja) * 2015-10-16 2018-10-18 ノースウェスタン ユニバーシティ 統合失調症、双極性障害、認知障害及び大うつ病性障害の治療のための非定型的抗精神病薬ならびにｎｍｄａ調節剤の医薬品の組み合わせ
US10487055B2 (en) 2016-06-01 2019-11-26 Rhode Island Board Of Education Diindole compounds useful in treatment of nervous system disorders
US11358935B2 (en) 2016-11-28 2022-06-14 Biohaven Pharmaceutical Holding Company Ltd. Prodrugs of lanicemine and their method of use
JP2021512857A (ja) * 2017-11-10 2021-05-20 ノーレックス インコーポレイテッド Ｎｍｄａ受容体アゴニストの投与方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011044089A2 (en) * 2009-10-05 2011-04-14 Joseph Moskal Methods of treating depression and other related diseases
WO2014011590A2 (en) * 2012-07-12 2014-01-16 Javitt Daniel C Composition and method for treatment of depression and psychosis in humans

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4086196A (en) 1975-03-28 1978-04-25 Armour Pharmaceutical Company Parathyroid hormone
US5763393A (en) 1996-05-17 1998-06-09 Neurotherapeutics L.P. Neuroactive peptides
US8951968B2 (en) * 2009-10-05 2015-02-10 Northwestern University Methods of treating depression and other related diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011044089A2 (en) * 2009-10-05 2011-04-14 Joseph Moskal Methods of treating depression and other related diseases
WO2014011590A2 (en) * 2012-07-12 2014-01-16 Javitt Daniel C Composition and method for treatment of depression and psychosis in humans

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KRYSTAL JOHN等: "Rapid-acting glutamatergic antidepressants:the path to keatmine and beyond", 《BIOLOGICAL PSYCHIATRY》 *
MESSNER M.等: "Maintenance keatmine treatment produces long-term recovery from depression", 《PRIMARY PSYCHIATRY》 *
MOSKAL JR.等: "GLYX-13，an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists", 《EXPERT OPINION ON INVESTIGATIONAL DRUGS》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111670041A (zh) * 2017-12-05 2020-09-15 诺雷克斯股份有限公司 用在组合疗法(睡眠障碍或中枢神经系统障碍)中的nmda受体调节剂(拉帕斯汀)组合

Also Published As

Publication number Publication date
UA123623C2 (uk) 2021-05-05
IL250557A0 (en) 2017-03-30
JP2017524721A (ja) 2017-08-31
JP2020128391A (ja) 2020-08-27
PH12017500275A1 (en) 2017-07-03
EP3180015A4 (en) 2018-02-14
EP3180015A1 (en) 2017-06-21
US20170296616A1 (en) 2017-10-19
KR20170040351A (ko) 2017-04-12
CL2017000378A1 (es) 2017-11-03
MX2017002052A (es) 2018-08-15
AU2020203165A1 (en) 2020-06-04
BR112017002930A2 (pt) 2017-12-05
RU2017107033A (ru) 2018-09-14
WO2016025721A1 (en) 2016-02-18
RU2017107033A3 (https=) 2019-02-12
CA2957937A1 (en) 2016-02-18
ZA201701526B (en) 2018-05-30
AU2015301650A1 (en) 2017-03-23
SG10201810016XA (en) 2018-12-28
SG11201701134XA (en) 2017-03-30
CO2017002356A2 (es) 2017-06-09

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