CN106620828A - Medical soft tissue adhesive and preparation method thereof - Google Patents
Medical soft tissue adhesive and preparation method thereof Download PDFInfo
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- CN106620828A CN106620828A CN201611126987.7A CN201611126987A CN106620828A CN 106620828 A CN106620828 A CN 106620828A CN 201611126987 A CN201611126987 A CN 201611126987A CN 106620828 A CN106620828 A CN 106620828A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
Abstract
The invention provides a medical soft tissue adhesive and a preparation method thereof. The preparation method comprises the following steps: (1) preparing alga extract; (2) fully stirring the alga extract prepared in the step (1), alpha-cyan n-butyl acrylate, hydroxypropyl methacrylate, polyurethane, polyethylene glycol and xanthan gum to obtain a mixture 1; (3) dissolving sodium dodecyl sulfate, polysaccharide alginate, oyster polysaccharide and benzyl hydrophobic modified starch in medical distilled water, and then adding soracan gum and stirring the mixture to obtain a mixture 2; and (4) adding the mixture 2 into the mixture 1, fully and uniformly stirring the mixture, and uniformly irradiating the mixture with gamma rays to obtain the medical soft tissue adhesive. The medical soft tissue adhesive provided by the invention has very high bonding strength and meanwhile, also has good bacteriostasis activity.
Description
Technical field
The present invention relates to field of medical materials, and in particular to a kind of medical soft tissue binding agent and preparation method thereof.
Background technology
Before the use of adhesive of medical can trace back to B.C. 3000, ancient Egyptian has used earliest a kind of with medical viscous
The mixture of mixture characteristic, later Greeks pull oil, lead oxide and water with olive and medical plaster shape mixture be obtained.But, directly
To in recent decades, adhesive of medical is just developed rapidly.Preferably adhesive of medical should possess following condition：（1）
Having under conditions of water and tissue fluid also can be glued；（2）Quick with tissue can be glued under normal temperature and pressure；（3）In the same of solidification
When, larger glue-joint strength can be produced with tissue；（4）Do not show toxicity, not mutagenesis, teratogenesis, not carcinogenic；（5）Without prejudice to is given birth to
Itself healing of object tissue；（6）Itself is aseptic and energy is antibacterial；（7）Cured glue body tool elasticity or toughness；（8）In one pack system
Liquid or pasty state, without nonaqueous solvent；（9）Can gradually degraded and absorbed, excretion in tissue；（10）It is easily stored under room temperature, use
Before need not allocate.But comply fully with the adhesive of medical of above-mentioned requirements not yet to study so far successfully.The binding agent that presently, there are
In yet suffer from bonding effect, the dissatisfactory situation of antibacterial effect.
The content of the invention
The technical problem to be solved：It is an object of the invention to provide a kind of medical soft tissue binding agent, with very high viscous
Knotting strength, while this soft tissue adhesives also has good biocidal property.
Technical scheme：A kind of medical soft tissue binding agent, is prepared from by weight by following component：Alpha-cyanoacrylate
N-butyl 50-70 part, Hydroxypropyl methacrylate 4-6 parts, polyurethane 2.5-4.5 parts, Polyethylene Glycol 8-12 parts, xanthan gum 4-12
Part, benzyl hydrophobic modification starch 1.8-4.5 parts, Salecan 0.03-0.06 parts, dodecyl sodium sulfate 0.05-0.15 parts, sea
The poly- polysaccharide 0.5-1 parts of alginic acid, Concha Ostreae polysaccharide 0.5-1 parts, Sargassum extract 0.2-0.8 parts, medical distilled water 20-30 parts.
It is further preferred that a kind of described medical soft tissue binding agent, is prepared from by weight by following component：α-
BCA 55-65 parts, Hydroxypropyl methacrylate 4.5-5.5 parts, polyurethane 3-4 parts, Polyethylene Glycol 9-11 parts,
Xanthan gum 6-10 parts, benzyl hydrophobic modification starch 2.5-3 parts, Salecan 0.04-0.05 parts, dodecyl sodium sulfate 0.08-
0.14 part, the poly- polysaccharide 0.6-0.8 parts of alginic acid, Concha Ostreae polysaccharide 0.6-0.8 parts, Sargassum extract 0.4-0.6 parts, medical distilled water
24-28 parts.
The preparation method of above-mentioned medical soft tissue binding agent, comprises the following steps：
（1）Dehydration Sargassum is weighed in Soxhlet extractor, adds 10 times of weight portions, mol ratio to be 1:1 dichloromethane：Normal hexane
Mixed liquor, 60-80 DEG C of extraction 12-20h is evaporated to dry, -20 DEG C of Refrigerator stores of use at 45 DEG C of extract Rotary Evaporators；
（2）By step（1）It is prepared Sargassum extract, α-cyanoacrylaten-butyl, Hydroxypropyl methacrylate, polyurethane, poly-
Ethylene glycol, xanthan gum, are sufficiently stirred for, and stir 40-60min, and speed is 20-40r/min, obtains mixture 1；
（3）Dodecyl sodium sulfate, the poly- polysaccharide of alginic acid, Concha Ostreae polysaccharide, benzyl hydrophobic modification starch are dissolved in into medical distillation
In water, Salecan is subsequently adding, mixing speed is 4-10r/min, and temperature is 20-50 DEG C, obtains mixture 2；
（4）Mixture 2 is added in mixture 1, after stirring, uniform irradiation 36-72h under gamma-rays, you can.
Further, the preparation method of described a kind of medical soft tissue binding agent, the step（1）Middle Extracting temperature is
65-75 DEG C, the time is 15h.
Further, the preparation method of described a kind of medical soft tissue binding agent, the step（2）Middle mixing time is
45-55min, speed is 25-35r/min.
Further, the preparation method of described a kind of medical soft tissue binding agent, the step（3）Middle rotating speed is 6r/
Min, temperature is 30-40 DEG C.
Further, the preparation method of described a kind of medical soft tissue binding agent, the step（4）Middle exposure time is
50-60h。
Beneficial effect：The medical soft tissue binding agent of the present invention has very high adhesion strength, reaches as high as 65.4MPa,
Simultaneously this soft tissue adhesives also has good biocidal property, by Bactericidal test it is found that staphylococcus aureuses
Average antibacterial circle diameter can most preferably reach 12.21mm, and the average antibacterial circle diameter of Hemolytic streptococcuss most preferably can be reached
12.21mm, many addition marine organisms are extracted and marine polysaccharide in the medical soft tissue, are primarily due to marine organisms with sea
Bonding between foreign rock, then realized by a kind of stickum secreted by them, the main component of this stickum
It is protein and polysaccharide, is in a liquid state or viscoelastic state, is conducive to forming strong adhesion with irregular surface.
Specific embodiment
Embodiment 1
A kind of medical soft tissue binding agent, is prepared from by weight by following component：50 parts of α-cyanoacrylaten-butyl, first
6 parts of base hydroxypropyl acrylate, 2.5 parts of polyurethane, 12 parts of Polyethylene Glycol, 4 parts of xanthan gum, 1.8 parts of benzyl hydrophobic modification starch,
0.06 part of Salecan, 0.15 part of dodecyl sodium sulfate, 0.5 part of the poly- polysaccharide of alginic acid, 0.5 part of Concha Ostreae polysaccharide, Sargassum extract
0.8 part, 30 parts of medical distilled water.
The preparation method of above-mentioned medical soft tissue binding agent is：（1）Dehydration Sargassum is weighed in Soxhlet extractor, 10 are added
Times weight portion, mol ratio are 1:1 dichloromethane：Normal hexane mixed liquor, 60 DEG C of extraction 20h, 45 DEG C of extract Rotary Evaporators
Under be evaporated to it is dry, use -20 DEG C of Refrigerator stores；（2）By step（1）Prepared Sargassum extract, α-cyanoacrylaten-butyl,
Hydroxypropyl methacrylate, polyurethane, Polyethylene Glycol, xanthan gum, are sufficiently stirred for, and stir 40min, and speed is 40r/min, obtains mixed
Compound 1；（3）Dodecyl sodium sulfate, the poly- polysaccharide of alginic acid, Concha Ostreae polysaccharide, benzyl hydrophobic modification starch are dissolved in into medical steaming
In distilled water, Salecan is subsequently adding, mixing speed is 10r/min, and temperature is 20 DEG C, obtains mixture 2；（4）Mixture 2 is added
In mixture 1, after stirring, uniform irradiation 72h under gamma-rays, you can.
Embodiment 2
A kind of medical soft tissue binding agent, is prepared from by weight by following component：70 parts of α-cyanoacrylaten-butyl, first
4 parts of base hydroxypropyl acrylate, 4.5 parts of polyurethane, 8 parts of Polyethylene Glycol, 12 parts of xanthan gum, 4.5 parts of benzyl hydrophobic modification starch,
0.03 part of Salecan, 0.05 part of dodecyl sodium sulfate, 1 part of the poly- polysaccharide of alginic acid, 1 part of Concha Ostreae polysaccharide, Sargassum extract 0.2
Part, 20 parts of medical distilled water.
The preparation method of above-mentioned medical soft tissue binding agent is：（1）Dehydration Sargassum is weighed in Soxhlet extractor, 10 are added
Times weight portion, mol ratio are 1:1 dichloromethane：Normal hexane mixed liquor, 80 DEG C of extraction 12h, 45 DEG C of extract Rotary Evaporators
Under be evaporated to it is dry, use -20 DEG C of Refrigerator stores；（2）By step（1）Prepared Sargassum extract, α-cyanoacrylaten-butyl,
Hydroxypropyl methacrylate, polyurethane, Polyethylene Glycol, xanthan gum, are sufficiently stirred for, and stir 60min, and speed is 20r/min, obtains mixed
Compound 1；（3）Dodecyl sodium sulfate, the poly- polysaccharide of alginic acid, Concha Ostreae polysaccharide, benzyl hydrophobic modification starch are dissolved in into medical steaming
In distilled water, Salecan is subsequently adding, mixing speed is 4r/min, and temperature is 50 DEG C, obtains mixture 2；（4）Mixture 2 is added
In mixture 1, after stirring, uniform irradiation 36h under gamma-rays, you can.
Embodiment 3
A kind of medical soft tissue binding agent, is prepared from by weight by following component：55 parts of α-cyanoacrylaten-butyl, first
5.5 parts of base hydroxypropyl acrylate, 3 parts of polyurethane, 9 parts of Polyethylene Glycol, 6 parts of xanthan gum, 2.5 parts of benzyl hydrophobic modification starch,
0.05 part of Salecan, 0.14 part of dodecyl sodium sulfate, 0.6 part of the poly- polysaccharide of alginic acid, 0.6 part of Concha Ostreae polysaccharide, Sargassum extract
0.6 part, 24 parts of medical distilled water.
The preparation method of above-mentioned medical soft tissue binding agent is：（1）Dehydration Sargassum is weighed in Soxhlet extractor, 10 are added
Times weight portion, mol ratio are 1:1 dichloromethane：Normal hexane mixed liquor, 65 DEG C of extraction 15h, 45 DEG C of extract Rotary Evaporators
Under be evaporated to it is dry, use -20 DEG C of Refrigerator stores；（2）By step（1）Prepared Sargassum extract, α-cyanoacrylaten-butyl,
Hydroxypropyl methacrylate, polyurethane, Polyethylene Glycol, xanthan gum, are sufficiently stirred for, and stir 45min, and speed is 35r/min, obtains mixed
Compound 1；（3）Dodecyl sodium sulfate, the poly- polysaccharide of alginic acid, Concha Ostreae polysaccharide, benzyl hydrophobic modification starch are dissolved in into medical steaming
In distilled water, Salecan is subsequently adding, mixing speed is 6r/min, and temperature is 30 DEG C, obtains mixture 2；（4）Mixture 2 is added
In mixture 1, after stirring, uniform irradiation 50h under gamma-rays, you can.
Embodiment 4
A kind of medical soft tissue binding agent, is prepared from by weight by following component：65 parts of α-cyanoacrylaten-butyl, first
4.5 parts of base hydroxypropyl acrylate, 4 parts of polyurethane, 11 parts of Polyethylene Glycol, 10 parts of xanthan gum, 3 parts of benzyl hydrophobic modification starch,
0.04 part of Salecan, 0.08 part of dodecyl sodium sulfate, 0.8 part of the poly- polysaccharide of alginic acid, 0.8 part of Concha Ostreae polysaccharide, Sargassum extract
0.4 part, 28 parts of medical distilled water.
The preparation method of above-mentioned medical soft tissue binding agent is：（1）Dehydration Sargassum is weighed in Soxhlet extractor, 10 are added
Times weight portion, mol ratio are 1:1 dichloromethane：Normal hexane mixed liquor, 75 DEG C of extraction 15h, 45 DEG C of extract Rotary Evaporators
Under be evaporated to it is dry, use -20 DEG C of Refrigerator stores；（2）By step（1）Prepared Sargassum extract, α-cyanoacrylaten-butyl,
Hydroxypropyl methacrylate, polyurethane, Polyethylene Glycol, xanthan gum, are sufficiently stirred for, and stir 55min, and speed is 25r/min, obtains mixed
Compound 1；（3）Dodecyl sodium sulfate, the poly- polysaccharide of alginic acid, Concha Ostreae polysaccharide, benzyl hydrophobic modification starch are dissolved in into medical steaming
In distilled water, Salecan is subsequently adding, mixing speed is 6r/min, and temperature is 40 DEG C, obtains mixture 2；（4）Mixture 2 is added
In mixture 1, after stirring, uniform irradiation 60h under gamma-rays, you can.
Embodiment 5
A kind of medical soft tissue binding agent, is prepared from by weight by following component：60 parts of α-cyanoacrylaten-butyl, first
5 parts of base hydroxypropyl acrylate, 3.5 parts of polyurethane, 10 parts of Polyethylene Glycol, 8 parts of xanthan gum, 2.8 parts of benzyl hydrophobic modification starch,
0.042 part of Salecan, 0.13 part of dodecyl sodium sulfate, 0.7 part of the poly- polysaccharide of alginic acid, 0.7 part of Concha Ostreae polysaccharide, Sargassum extract
0.5 part, 26 parts of medical distilled water.
The preparation method of above-mentioned medical soft tissue binding agent is：（1）Dehydration Sargassum is weighed in Soxhlet extractor, 10 are added
Times weight portion, mol ratio are 1:1 dichloromethane：Normal hexane mixed liquor, 70 DEG C of extraction 15h, 45 DEG C of extract Rotary Evaporators
Under be evaporated to it is dry, use -20 DEG C of Refrigerator stores；（2）By step（1）Prepared Sargassum extract, α-cyanoacrylaten-butyl,
Hydroxypropyl methacrylate, polyurethane, Polyethylene Glycol, xanthan gum, are sufficiently stirred for, and stir 50min, and speed is 30r/min, obtains mixed
Compound 1；（3）Dodecyl sodium sulfate, the poly- polysaccharide of alginic acid, Concha Ostreae polysaccharide, benzyl hydrophobic modification starch are dissolved in into medical steaming
In distilled water, Salecan is subsequently adding, mixing speed is 6r/min, and temperature is 35 DEG C, obtains mixture 2；（4）Mixture 2 is added
In mixture 1, after stirring, uniform irradiation 55h under gamma-rays, you can.
Comparative example 1
A kind of medical soft tissue binding agent, is prepared from by weight by following component：50 parts of α-cyanoacrylaten-butyl, first
6 parts of base hydroxypropyl acrylate, 2.5 parts of polyurethane, 12 parts of Polyethylene Glycol, 4 parts of xanthan gum, 0.5 part of the poly- polysaccharide of alginic acid, Concha Ostreae are more
0.5 part of sugar, 0.8 part of Sargassum extract, 30 parts of medical distilled water.
The preparation method of above-mentioned medical soft tissue binding agent is：（1）Dehydration Sargassum is weighed in Soxhlet extractor, 10 are added
Times weight portion, mol ratio are 1:1 dichloromethane：Normal hexane mixed liquor, 60 DEG C of extraction 20h, 45 DEG C of extract Rotary Evaporators
Under be evaporated to it is dry, use -20 DEG C of Refrigerator stores；（2）By step（1）Prepared Sargassum extract, α-cyanoacrylaten-butyl,
Hydroxypropyl methacrylate, polyurethane, Polyethylene Glycol, xanthan gum, are sufficiently stirred for, and stir 40min, and speed is 40r/min, obtains mixed
Compound 1；（3）The poly- polysaccharide of alginic acid, Concha Ostreae polysaccharide are dissolved in medical distilled water, mixing speed is 40r/min, temperature is 20
DEG C, obtain mixture 2；（4）Mixture 2 is added in mixture 1, after stirring, uniform irradiation 72h under gamma-rays, i.e.,
Can.
Comparative example 2
A kind of medical soft tissue binding agent, is prepared from by weight by following component：70 parts of α-cyanoacrylaten-butyl, first
4 parts of base hydroxypropyl acrylate, 4.5 parts of polyurethane, 8 parts of Polyethylene Glycol, 12 parts of xanthan gum, 4.5 parts of benzyl hydrophobic modification starch,
0.03 part of Salecan, 0.05 part of dodecyl sodium sulfate, 20 parts of medical distilled water.
The preparation method of above-mentioned medical soft tissue binding agent is：（1）By α-cyanoacrylaten-butyl, hydroxyethyl methacrylate
Propyl ester, polyurethane, Polyethylene Glycol, xanthan gum, are sufficiently stirred for, and stir 60min, and speed is 20r/min, obtains mixture 1；（2）Will
Dodecyl sodium sulfate, benzyl hydrophobic modification starch are dissolved in medical distilled water, are subsequently adding Salecan, and mixing speed is
4r/min, temperature is 50 DEG C, obtains mixture 2；（3）Mixture 2 is added in mixture 1, after stirring, under gamma-rays
Uniform irradiation 36h, you can.
Embodiment 1 to 5 and comparative example 1,2 gained binding agents are carried out into performance test.
The assay method of adhesion strength：According to YY/T0729.1 tissue adhesives adhesive property test method part 1：Take
Connect-shear tension bearing strength tested.
Antibacterial ring size experimental technique：(1) preparation of bacteria inhibition tablet：The binding agent of Example and matched group, binding agent is direct
Air-dry, make a diameter of 5mm, thickness is less than 4mm disks, per 4 one group；(2) inoculation of test organismss：Dipped with sterile cotton swab
Concentration is 5 × 105cfu/ml-5 × 106cfu/ml test bacteria suspensions, in nutrient agar planar surface uniform application 3
It is secondary.Often smear 1 time, flat board should rotate 60 °, finally cotton swab is smeared into one week around plate edge.Plate is covered, drying at room temperature is put
5min；(3) antibacterial print is placed with：Test every time is placed with 1 microbiological contamination flat board, and each flat board is placed with 4 test prints.With aseptic
Tweezers coupongs are placed with planar surface.At a distance of more than 25mm between each print center, with the periphery of flat board at a distance of more than 15mm.
After being placed with, with the light pressure-like piece of aseptic nipper so as to be close to planar surface.Plate is covered, 37 DEG C of incubators are put, 16h- is cultivated
18h observes result.With the diameter of vernier caliper measurement antibacterial ring size and record.Test is repeated 3 times.
The property indices of material of the present invention see the table below, it may be seen that this medical soft tissue binding agent is with very high
Adhesion strength, reach as high as 65.4MPa, at the same this soft tissue adhesives also have good biocidal property, by inhibition zone reality
Test it is found that the average antibacterial circle diameter of staphylococcus aureuses can most preferably reach 12.21mm, to Hemolytic streptococcuss
Average antibacterial circle diameter can most preferably reach 12.21mm, and many addition marine organisms are extracted and ocean life in the medical soft tissue
Thing polysaccharide, is primarily due to bonding between marine organisms and ocean rock, then be by a kind of stickum reality secreted by them
Existing, the main component of this stickum is protein and polysaccharide, is in a liquid state or viscoelastic state, is conducive to and irregular surface shape
Into strong adhesion.
The property indices of the medical soft tissue binding agent of table 1
Claims (7)
1. a kind of medical soft tissue binding agent, it is characterised in that be prepared from by weight by following component：Alpha-cyanoacrylate
N-butyl 50-70 part, Hydroxypropyl methacrylate 4-6 parts, polyurethane 2.5-4.5 parts, Polyethylene Glycol 8-12 parts, xanthan gum 4-12
Part, benzyl hydrophobic modification starch 1.8-4.5 parts, Salecan 0.03-0.06 parts, dodecyl sodium sulfate 0.05-0.15 parts, sea
The poly- polysaccharide 0.5-1 parts of alginic acid, Concha Ostreae polysaccharide 0.5-1 parts, Sargassum extract 0.2-0.8 parts, medical distilled water 20-30 parts.
2. a kind of medical soft tissue binding agent according to claim 1, it is characterised in that made by weight by following component
It is standby to form：α-cyanoacrylaten-butyl 55-65 parts, Hydroxypropyl methacrylate 4.5-5.5 parts, polyurethane 3-4 parts, poly- second two
Alcohol 9-11 parts, xanthan gum 6-10 parts, benzyl hydrophobic modification starch 2.5-3 parts, Salecan 0.04-0.05 parts, dodecyl sulphur
Sour sodium 0.08-0.14 parts, the poly- polysaccharide 0.6-0.8 parts of alginic acid, Concha Ostreae polysaccharide 0.6-0.8 parts, Sargassum extract 0.4-0.6 parts,
Medical distilled water 24-28 parts.
3. a kind of preparation method of medical soft tissue binding agent, it is characterised in that comprise the following steps：
（1）Dehydration Sargassum is weighed in Soxhlet extractor, adds 10 times of weight portions, mol ratio to be 1:1 dichloromethane：Normal hexane
Mixed liquor, 60-80 DEG C of extraction 12-20h is evaporated to dry, -20 DEG C of Refrigerator stores of use at 45 DEG C of extract Rotary Evaporators；
（2）By step（1）It is prepared Sargassum extract, α-cyanoacrylaten-butyl, Hydroxypropyl methacrylate, polyurethane, poly-
Ethylene glycol, xanthan gum, are sufficiently stirred for, and stir 40-60min, and speed is 20-40r/min, obtains mixture 1；
（3）Dodecyl sodium sulfate, the poly- polysaccharide of alginic acid, Concha Ostreae polysaccharide, benzyl hydrophobic modification starch are dissolved in into medical distillation
In water, Salecan is subsequently adding, mixing speed is 4-10r/min, and temperature is 20-50 DEG C, obtains mixture 2；
（4）Mixture 2 is added in mixture 1, after stirring, uniform irradiation 36-72h under gamma-rays, you can.
4. the preparation method of a kind of medical soft tissue binding agent according to claim 3, it is characterised in that：The step
（1）Middle Extracting temperature is 65-75 DEG C, and the time is 15h.
5. the preparation method of a kind of medical soft tissue binding agent according to claim 3, it is characterised in that：The step
（2）Middle mixing time is 45-55min, and speed is 25-35r/min.
6. the preparation method of a kind of medical soft tissue binding agent according to claim 3, it is characterised in that：The step
（3）Middle rotating speed is 6r/min, and temperature is 30-40 DEG C.
7. the preparation method of a kind of medical soft tissue binding agent according to claim 3, it is characterised in that：The step
（4）Middle exposure time is 50-60h.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107412846A (en) * | 2017-07-27 | 2017-12-01 | 苏州凌科特新材料有限公司 | A kind of composite antibacterial medical adhesive and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107412846A (en) * | 2017-07-27 | 2017-12-01 | 苏州凌科特新材料有限公司 | A kind of composite antibacterial medical adhesive and preparation method thereof |
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