CN104587519B - A kind of dressing paste containing Chinese medicine - Google Patents
A kind of dressing paste containing Chinese medicine Download PDFInfo
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- CN104587519B CN104587519B CN201410833689.6A CN201410833689A CN104587519B CN 104587519 B CN104587519 B CN 104587519B CN 201410833689 A CN201410833689 A CN 201410833689A CN 104587519 B CN104587519 B CN 104587519B
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Abstract
The present invention provides a kind of dressing paste containing Chinese medicine, and including carcass, non-drying glue layer, functional dressings layer and strippable protecting film, described functional dressings layer is formed by stacking by two-layer gauze, is provided with Chinese medicinal powder interlayer between gauze；Described Chinese medicinal powder includes component one and component two, and described component one is Fructus Jujubae pectin, Borneolum Syntheticum, Alumen, and described component two is Radix Et Rhizoma Rhei, Fructus Chebulae Flos Carthami three through the dried powder of water boiling concentration.There is obvious synergism between component one and component two in the dressing paste of the present invention, the increment of cell can be effectively facilitated, promote the healing of wound；In addition, the application dressing paste has excellent antibacterial effect, be not in wound and periphery is red, swollen, hot, pain symptom in use, can effectively eliminate bacterium infection, it is to avoid the generation of inflammation, mitigate patient suffering.
Description
Technical field
The present invention relates to a kind of dressing paste, especially a kind of dressing paste containing Chinese medicine.
Background technology
Traditional wound dressing is divided into dry gauze and oily yarn, and dry type traditional dressing can play to wound supervision covering effect,
Cannot be used for infected wound, sepage manages limited in one's ability, adhesion wound, and newborn epithelial tissue can be damaged again, patient changes
Pain after dressing.Oily yarn type dressing is because containing vaseline or triglyceride, avoiding adhesion wound, but still can not promote to heal
Close.Simultaneously as the liquid of wound surface secretion can not pass through carcass, cause the immersion to local skin, make wound and surrounding skin
Skin bleaches, and serious meeting makes skin rot, and wound is even more difficult to heal.Domestic type of hydrogel simple on the market contains alginic acid
The medical dressing of calcium can avoid adhesion wound, promote healing, but expensive, with the Sargassum of a piece of 10cm × 10cm specification
Sour dressing selling price is about 60 yuans, and its application is subject to certain restrictions.Other bearing hydrocolloid dressings or foam
Used in dressing, other macromolecular compounds such as polyurethane polyureas, to reach sorptivety liquid effect, to protect wound surface to prevent adhesion, but
It is that promoting healing effect is unsatisfactory.
Fructus Jujubae is the characteristic fruit of China, has long cultivation history, red date nutrient is abundant and comprehensive, is that one kind has
The fruit of very high nutrition and medical value.As traditional nourishing food, Fructus Jujubae is always liked by broad masses deeply.China is red
Fructus Jujubae aboundresources, is red dates production big country, produces more than 180 ten thousand tons of Fructus Jujubae per year, accounts for more than the 95% of Gross World Product.But always with
Come, Fructus Jujubae converted productss form is single, processing mode falls behind, added value of product is low.How to enrich the species of Fructus Jujubae product, improve
Fructus Jujubae product utilization rate, is the problem of the common concern of scientific worker, is also to aid in Fructus Jujubae area and is effectively realized resources advantage, market
Advantage, the important topic of economic advantages conversion.
Pectin is one of composition of fabric cell wall, is present in the cellular layer between flanking cell wall, plays and glue cell
Effect together.The pectin of separate sources, its characteristic is also each variant.In natural pectin, about 20%～60% carboxyl is by ester
Change, molecular weight is 20,000～40,000.Pectin is the white powder thing of yellowish, soluble in water, forms sticky tasteless solution, band
Negative electricity.Pectin is a kind of natural polymer, has good gelatine and emulsion stability effect.
Specific esterification degree is low, the high feature of Gel baits because it has for Fructus Jujubae pectin, and is bonded with active factorses on long-chain, removes
Have common pectin possessed gelation, stability, outside strong water absorbing and retaining properties, it promotes wound wound healing, removes cicatrix
Effect is fabulous.One kind is reported by the use of Fructus Jujubae pectin and Borneolum Syntheticum, Alumen mixture as feature in patent CN103263687A
The dressing paste of adjuvant layer, it can effectively facilitate wound healing, will not stick together, but its bactericidal effect is poor, and wound is easy
Phenomenon that is red and swollen, suppurating occurs.
Content of the invention
The technical problem to be solved in the present invention is：Overcome the shortcomings of that in prior art, dressing paste bactericidal effect is poor, provide
A kind of dressing paste containing Chinese medicine.
The technical solution adopted for the present invention to solve the technical problems is：A kind of dressing paste containing Chinese medicine, including adhesive plaster
Layer, non-drying glue layer, functional dressings layer and strippable protecting film, described functional dressings layer is formed by stacking by two-layer gauze,
It is provided with Chinese medicinal powder interlayer between gauze；Described Chinese medicinal powder includes component one and component two, and described component one is Fructus Jujubae
Pectin, Borneolum Syntheticum, Alumen, described component two is Radix Et Rhizoma Rhei, Fructus Chebulae Flos Carthami three through the dried powder of water boiling concentration.
Further, in the component one described in described component one, the mass ratio of Fructus Jujubae pectin, Borneolum Syntheticum and Alumen is 50：
(1-5)：(1-10)；Described component two is Radix Et Rhizoma Rhei, Fructus Chebulae's Flos Carthami with mass ratio for 1：(0.5～2)：(1～1.5) mix
The powder that common water boiling concentration is obtained after being dried；The mass ratio of described component one and component two is 5～15:1.
Preferably, described Radix Et Rhizoma Rhei, Fructus Chebulae's Flos Carthami three's mass ratio are 1：1：1.
Further, in described component one, the mass ratio of Fructus Jujubae pectin, Borneolum Syntheticum and Alumen is 50：(1-5)：(1-10)；
Described component two is Radix Et Rhizoma Rhei and Fructus Chebulae 1：The powder that (0.5～2) common water boiling concentration is obtained after being dried is big with described life
The mixture of the powder that the Flos Carthami of yellow 0.2～0.8 times of quality obtains after being dried through water boiling concentration；Described component one and component two
Mass ratio is 25～40:1.
Preferably, described component two is Radix Et Rhizoma Rhei and Fructus Chebulae 1：The powder that 1 common water boiling concentration is obtained after being dried with
The mixture of the powder obtaining after being dried through water boiling concentration with the Flos Carthami of described 0.5 times of quality of Radix Et Rhizoma Rhei.
Preferably, described Fructus Jujubae pectin is prepared as follows,
(1) pretreatment of raw material：By Fructus Jujubae through cleaning, going matter, ultra violet lamp sterilization, dry, shred, boiling and boil 5-10min,
Then alkaline aqueous solution and the mixed liquor of dehydrated alcohol is used to soak Fructus Jujubae 30min-60min at 60 DEG C -80 DEG C, filter screen leaches red
Fructus Jujubae；
(2) supersound extraction：The acidic aqueous solution being 2-3 with pH is with 1:The ratio of 5-15 adds the Fructus Jujubae that step (1) obtains
In, in 30 DEG C of -60 DEG C of tepidariums, supersound extraction Fructus Jujubae 10min-40min, obtains extracting solution；
(3) filtering and concentrating：Extracting solution is filtered, concentrates, adjusting pH is neutrality；
(4) decolour：By 30%H2O2It is added in concentrated solution and carry out the 6-12h that decolours；
(5) precipitate：Add dehydrated alcohol-ammonia water mixture so that pectin is precipitated, be centrifuged in the solution after decolouring, repeat one
Secondary；
(6) it is dried：Wet for the Fructus Jujubae obtaining pectin, it is spray-dried, obtains Fructus Jujubae pectin powder.
The invention has the beneficial effects as follows, there is significantly collaborative work in the dressing paste of the present invention between component one and component two
With the increment of cell can be effectively facilitated, and promote the healing of wound, and dressing paste of the present invention has good water absorption and lock
Aqueouss, can make wound will not stick together, festering also scar connective will not due to excessive dehydration；In addition, the application applies
Material patch has excellent antibacterial effect, is not in wound and periphery is red, swollen, hot, pain symptom, Neng Gouyou in use
Effect eliminates bacterium infection, it is to avoid the generation of inflammation, mitigates patient suffering.
Brief description
Fig. 1 is dressing paste structural representation of the present invention.
The strippable protecting film of in figure 1., 2. functional dressings layer, 3. non-drying glue layer, 4. carcass.
Specific embodiment
In conjunction with the accompanying drawings, the present invention is further detailed explanation.These accompanying drawings are the schematic diagram of simplification, only with
Illustration illustrates the basic structure of the present invention, and therefore it only shows the composition relevant with the present invention.
Embodiment 1
The preparation of Fructus Jujubae pectin：Take Fructus Jujubae 1500g to clean, then sterilized with ultra violet lamp, dry, shred at 80 DEG C,
The Fructus Jujubae being dried is put into boiling water heating 5min makes pectin enzyme-deactivating.Then the NaOH solution being 12 with pH and dehydrated alcohol are by matter
Amount compares 1：3 mixing, are 5 by mixed liquor and Fructus Jujubae mass ratio:NaOH is added in Fructus Jujubae by 1 with dehydrated alcohol mixed liquor, 70 DEG C
Soak 50min and remove most pigments, calcium iron ion and lipid components, filter screen leaches Fructus Jujubae.The phosphoric acid being 2 with pH is water-soluble
Liquid, supersound extraction Fructus Jujubae 30min in the tepidarium of temperature 60 C.Filter extracting solution, filtrate concentrated in vacuo to relative density 1.2,
It is adjusted to neutrality, (mass fraction) H2O2 (30%H2O2 in concentrated solution of plus 30%：Concentrated solution=1：1) decolour 12h, plus 4 times of bodies
Long-pending 92% ethanol-ammonia water mixture, in the solution decolouring, makes pectin precipitate, then the ethanol purge once fruit with same concentration
Glue, is dissolved in suitable quantity of water pectin, is spray-dried, obtains faint yellow pectin powder 47.2g, the pectin being prepared from is positioned over aseptic
Preserve in environment.
Through gel chromatography detection, this Fructus Jujubae pectin molecule amount up to 4.4 × 105；Be fourier transformed spectrographic determination its
Esterification degree, below 35%.
Embodiment 2
The Chinese medicine ingredients of dressing paste are component one：Fructus Jujubae pectin 10g, Borneolum Syntheticum 0.5g, Alumen 2g, component two：Radix Et Rhizoma Rhei, scold
Sub- Flos Carthami three is with mass ratio 1:0.5：1 mixing, common decocting, concentrated dried powder 1g, by component one and component
Two mix homogeneously, as dressing, mixed-powder are uniformly sprayed between two panels sterilizing yarn, make function dressing layer 2, then work(
Can dressing layer 2 according to dressing paste production technology, in conjunction with the carcass 4 scribbling non-drying glue layer 3, functional dressings layer 2 surface
And carcass 4 surface covers one layer of strippable protecting film 1 (PVDC), it is packaged into bag.During use, peel off PVDC film, by function
Dressing layer 2 is directed at wound location, wound surrounding.
Embodiment 3
The Chinese medicine ingredients of dressing paste are component one：Fructus Jujubae pectin 10g, Borneolum Syntheticum 0.2g, Alumen 1g, component two：Radix Et Rhizoma Rhei, scold
Sub- Flos Carthami three is with mass ratio 1:1：1.5 mixing, common decocting, concentrated dried powder 2.2g, by component one and group
Divide two mix homogeneously as dressing, mixed-powder is uniformly sprayed between two panels sterilizing yarn, makes dressing layer (2), dressing paste
Preparation method and using method are with embodiment 2.
Embodiment 4
The Chinese medicine ingredients of dressing paste are component one：Fructus Jujubae pectin 10g, Borneolum Syntheticum 0.2g, Alumen 1g, component two：Radix Et Rhizoma Rhei, scold
Sub- Flos Carthami three is with mass ratio 1:1：1 mixing, common decocting, concentrated dried powder 2.2g, by component one and component
Two mix homogeneously, as dressing, mixed-powder are uniformly sprayed between two panels sterilizing yarn, make dressing layer (2), dressing paste system
Preparation Method and using method are with embodiment 2.
Embodiment 5
The Chinese medicine ingredients of dressing paste are component one：Fructus Jujubae pectin 10g, Borneolum Syntheticum 1g, Alumen 0.2g, component two：Radix Et Rhizoma Rhei, scold
Sub- Flos Carthami three is with mass ratio 1:2：1 mixing, common decocting, concentrated dried powder 0.75g, by component one and component
Two mix homogeneously, as dressing, mixed-powder are uniformly sprayed between two panels sterilizing yarn, make dressing layer (2), dressing paste system
Preparation Method and using method are with embodiment 2.
Embodiment 6
The Chinese medicine ingredients of dressing paste are component one：Fructus Jujubae pectin 10g, Borneolum Syntheticum 0.5g, Alumen 2g, component two：Radix Et Rhizoma Rhei with
Both Fructus Chebulaes are with mass ratio 1:0.5 mixing, common decocting, concentrated dried powder one, 0.5 times of Radix Et Rhizoma Rhei quality red
Flower, the powder two after decocting, concentrate drying, powder one and powder two mix homogeneously take its mixed-powder 0.5g as group
Divide two, using component one and component two mix homogeneously as dressing, mixed-powder is uniformly sprayed between two panels sterilizing yarn, makes
Dressing layer (2), dressing paste preparation method and using method are with embodiment 2.
Embodiment 7
The Chinese medicine ingredients of dressing paste are component one：Fructus Jujubae pectin 10g, Borneolum Syntheticum 0.2g, Alumen 1g, component two：Radix Et Rhizoma Rhei with
Both Fructus Chebulaes are with mass ratio 1:1 mixing, common decocting, concentrated dried powder one, the Flos Carthami that 0.8 times of Radix Et Rhizoma Rhei quality,
Powder two after decocting, concentrate drying, powder one and powder two mix homogeneously take its mixed-powder 0.4g as component
Two, using component one and component two mix homogeneously as dressing, mixed-powder is uniformly sprayed between two panels sterilizing yarn, makes deposited
The bed of material (2), dressing paste preparation method and using method are with embodiment 2.
Embodiment 8
The Chinese medicine ingredients of dressing paste are component one：Fructus Jujubae pectin 10g, Borneolum Syntheticum 0.2g, Alumen 1g, component two：Radix Et Rhizoma Rhei with
Both Fructus Chebulaes are with mass ratio 1:1 mixing, common decocting, concentrated dried powder one, the Flos Carthami that 0.5 times of Radix Et Rhizoma Rhei quality,
Powder two after decocting, concentrate drying, powder one and powder two mix homogeneously take its mixed-powder 0.4g as component
Two, using component one and component two mix homogeneously as dressing, mixed-powder is uniformly sprayed between two panels sterilizing yarn, makes deposited
The bed of material (2), dressing paste preparation method and using method are with embodiment 2.
Embodiment 9
The Chinese medicine ingredients of dressing paste are component one：Fructus Jujubae pectin 10g, Borneolum Syntheticum 0.2g, Alumen 1g, component two：Radix Et Rhizoma Rhei with
Both Fructus Chebulaes are with mass ratio 1:2 mixing, common decocting, concentrated dried powder one, the Flos Carthami that 0.2 times of Radix Et Rhizoma Rhei quality,
Powder two after decocting, concentrate drying, powder one and powder two mix homogeneously take its mixed-powder 0.3g as component
Two, using component one and component two mix homogeneously as dressing, mixed-powder is uniformly sprayed between two panels sterilizing yarn, makes deposited
The bed of material (2), dressing paste preparation method and using method are with embodiment 2.
Comparative example 1
Component two consumption in embodiment 3 is increased to 2.8g, other conditions are same as Example 3.
Comparative example 2
Component two consumption in embodiment 5 is reduced to 0.6g, other conditions are same as Example 3.
Comparative example 3
Radix Et Rhizoma Rhei, Fructus Chebulae and Flos Carthami proportions in embodiment 3 are adjusted to 1:1:0.5, other conditions are with embodiment 3.
Comparative example 4
Radix Et Rhizoma Rhei, Fructus Chebulae and Flos Carthami proportions in embodiment 4 are adjusted to 1:1:2, other conditions are with embodiment 4.
Comparative example 5
Component in embodiment 6 two mixed-powder consumption is increased to 0.6g, other conditions are same as Example 6.
Comparative example 6
Component in embodiment 9 two mixed-powder consumption is reduced to 0.2g, other conditions are same as Example 9.
Comparative example 7
Flos Carthami consumption increase in embodiment 7 is equal with described Radix Et Rhizoma Rhei quality, other conditions are with embodiment 7.
Comparative example 8
Flos Carthami consumption in embodiment 9 is reduced to 0.1 times of described Radix Et Rhizoma Rhei quality, other conditions are with embodiment 8.
In order to characterize the healing ability to wound for the Fructus Jujubae pectin of present invention preparation, carry out following fibrocellular increment real
Test：
The cell that newborn skin is used is as cultured cells, high sugared in the DMEM of 10% (mass fraction) new-born calf serum
Culture fluid, 5% (volume fraction) CO2, carry out cultivating 24 hours under the conditions of 37 DEG C, be then inoculated into respectively, the matter of Chinese medicine ingredients
Amount percentage composition is 1%, in the high sugar culture fluid of the DMEM containing 0.5% (mass fraction) new-born calf serum, is further cultured for 48 hours,
Wherein Chinese medicine ingredients are added in two kinds of situation, one, described Chinese medicine ingredients be that (dressing is component one for the dressing of each embodiment preparation
Mixed-powder with component two) and comparative example in preparation dressing；2nd, as a comparison, individually add component one in each embodiment
Or component two is as described Chinese medicine ingredients (Chinese medicine ingredients percentage composition in culture fluid is 1%)；In addition, as blank right
According to carrying out in DMEM containing 0.5% (mass fraction) new-born calf serum high sugar culture fluid being not added with any Chinese medicine ingredients
Culture 48 hours.Counted with regular growth method of counting.Value-added effect such as table 1：
In each embodiment of table 1, Chinese medicine ingredients act on to fibroblastic increment
From table 1, data can be seen that the Fructus Jujubae pectin cell proliferation of component one in dressing of the present invention very big rush
Enter effect, component two cell proliferation also has certain facilitation, and component one and component two collective effect cell proliferation
Facilitation effect be much larger than component one and component two effect sum, illustrate there is certain synergism between the two；In addition, group
Two are divided to adopt Radix Et Rhizoma Rhei and the common decocting of Fructus Chebulae, the mode of the independent decocting of Flos Carthami is compared to three's common decocting cell proliferation
Facilitation is more preferable, and component two adopts Radix Et Rhizoma Rhei and the common decocting of Fructus Chebulae, the mode of the independent decocting of Flos Carthami and component one
Synergistic action effect becomes apparent from, and when this is probably three's common decocting, in Chinese medicine under uniform temperature, some effective ingredient occur instead
Should and the reason timeliness.
Respectively child, middle age, old man are carried out with the dressing paste patch of various embodiments of the present invention and comparative example preparation 4cm with
Interior general wound carries out nursing experimental, finds all there is preferable healing effect to the wound of each age group patient, and used
Wound does not occur in journey and periphery is red, swollen, hot, pain symptom, can effectively eliminate bacterium infection, it is to avoid the generation of inflammation, and
In patent 201310225982.X the biological dressing paste of report due to its antibacterial effect limited, easily occur slight red, swollen,
The inflammation such as heat, pain.
Claims (3)
1. a kind of dressing paste containing Chinese medicine it is characterised in that：Including carcass (4), non-drying glue layer (3), functional dressings layer (2)
And strippable protecting film (1), described functional dressings layer (2) is formed by stacking by two-layer gauze, in being provided between gauze
Medicine pulverous interlayer；Described Chinese medicinal powder includes component one and component two, and described component one is Fructus Jujubae pectin, Borneolum Syntheticum, Alumen, institute
Stating component two is Radix Et Rhizoma Rhei, Fructus Chebulae Flos Carthami three through the dried powder of water boiling concentration；
In described component one, the mass ratio of Fructus Jujubae pectin, Borneolum Syntheticum and Alumen is 50：(1-5)：(1-10)；Described component two is
Radix Et Rhizoma Rhei and Fructus Chebulae 1：The powder that (0.5～2) common water boiling concentration is obtained after being dried with described 0.2～0.8 times of matter of Radix Et Rhizoma Rhei
The mixture of the powder that the Flos Carthami of amount obtains after being dried through water boiling concentration；The mass ratio of described component one and component two be 25～
40:1.
2. the dressing paste containing Chinese medicine according to claim 1 it is characterised in that：Described component two be Radix Et Rhizoma Rhei with scold
Son 1：The powder that 1 common water boiling concentration is obtained after being dried is dried through water boiling concentration with the Flos Carthami of described 0.5 times of quality of Radix Et Rhizoma Rhei
The mixture of the powder obtaining afterwards.
3. the dressing paste containing Chinese medicine according to claim 1 it is characterised in that：Described Fructus Jujubae pectin is by the following method
Preparation：
(1) pretreatment of raw material：By Fructus Jujubae through cleaning, going matter, ultra violet lamp sterilization, dry, shred, boiling and boil 5-10min, then
Soak Fructus Jujubae 30min-60min with the mixed liquor of alkaline aqueous solution and dehydrated alcohol at 60 DEG C -80 DEG C, filter screen leaches Fructus Jujubae；
(2) supersound extraction：The acidic aqueous solution being 2-3 with pH is with 1:The ratio of 5-15 adds in the Fructus Jujubae that step (1) obtains,
In 30 DEG C of -60 DEG C of tepidariums, supersound extraction Fructus Jujubae 10min-40min, obtains extracting solution；
(3) filtering and concentrating：Extracting solution is filtered, concentrates, adjusting pH is neutrality；
(4) decolour：By 30%H2O2It is added in concentrated solution and carry out the 6-12h that decolours；
(5) precipitate：Add dehydrated alcohol-ammonia water mixture so that pectin is precipitated, be centrifuged in the solution after decolouring, be repeated once；
(6) it is dried：Wet for the Fructus Jujubae obtaining pectin, it is spray-dried, obtains Fructus Jujubae pectin powder.
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| CN105457080A (en) * | 2015-12-09 | 2016-04-06 | 安徽宇宁生物科技有限公司 | Pectin adhesive bandage |
| CN105963854A (en) * | 2016-04-28 | 2016-09-28 | 长葛市怡盛蜂业有限公司 | Beeswax physiotherapy tape |
| CN107854716B (en) * | 2017-09-27 | 2020-10-02 | 广州润虹医药科技股份有限公司 | Antibacterial and dehumidifying dressing patch and preparation method thereof |
| CN109125712A (en) * | 2018-09-26 | 2019-01-04 | 南阳市中心医院 | A kind of burned infants scald anesthesia dressing patch |
| CN109435360A (en) * | 2018-12-14 | 2019-03-08 | 苏州高研纺织科技有限公司 | A kind of new medical functional fabric |
| CN111773242A (en) * | 2020-07-21 | 2020-10-16 | 江苏省健尔康医用敷料有限公司 | Surgical towel and preparation method thereof |
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| JP2006347902A (en) * | 2005-06-14 | 2006-12-28 | Ogawa & Co Ltd | Moisture retention plant extract, and external preparation, cosmetic product, bathing agent and detergent containing the extract |
| CN1915404A (en) * | 2006-08-01 | 2007-02-21 | 周文友 | Chinese traditional medicine for treating psoriasis |
| CN101167856B (en) * | 2007-10-26 | 2010-06-02 | 郭光华 | External-applied medicinal preparation for treating burns and its preparation method |
| CN101249190B (en) * | 2008-03-28 | 2010-12-15 | 李春华 | Anti-inflammation sterilizing Chinese medicine compound externally used coating liquid and method of preparing the same |
| CN103263687B (en) * | 2013-06-07 | 2014-07-30 | 南京美纯生物科技有限公司 | Biological type dressing paster |
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