CN106620585A - Medicine composition for treating vomit - Google Patents

Medicine composition for treating vomit Download PDF

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Publication number
CN106620585A
CN106620585A CN201510753750.0A CN201510753750A CN106620585A CN 106620585 A CN106620585 A CN 106620585A CN 201510753750 A CN201510753750 A CN 201510753750A CN 106620585 A CN106620585 A CN 106620585A
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China
Prior art keywords
parts
pharmaceutical composition
medicine composition
coptis
extract
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CN201510753750.0A
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Chinese (zh)
Inventor
代宝泉
李梅
何骋
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Dongfang Kaien Medicine Sci & Tech Co Ltd Beijing
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Dongfang Kaien Medicine Sci & Tech Co Ltd Beijing
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Abstract

The invention relates to a medicine composition for preventing and treating vomit. The medicine composition comprises, by weight, 5-20 parts of radix scutellariae, 5-20 parts of pericarpium citri reticulatae, 3-10 parts of rhizoma coptidis, 5-20 parts of caulis perillae, 5-20 parts of rhizoma pinelliae preparata, 5-20 parts of flos caryophylli, 10-40 parts of raw radix astragali, 3-10 parts of radix glycyrrhizae, 3-10 parts of dry radix ginseng, 5-20 parts of poria and 3-10 parts of fructus evodiae. The medicine composition has the advantage that good prevention and anti-vomiting effects can be realized by the medicine composition for vomit symptoms due to various causes.

Description

A kind of pharmaceutical composition for treating vomiting
【Technical field】
The present invention relates to a kind of pharmaceutical composition for treatment vomiting, belongs to technical field of traditional Chinese medicines,.
【Technical background】
As the continuous progress of society, global tumor incidence are also persistently raised, reason is varied, such as bad life style (such as smoking), evil Disposition thread (such as stress is big but cannot discharge, constrain for a long time, melancholy), (such as the environmental pollution of sky gas and water, causes environmental degradation The death rate of lung cancer is higher than non-industrial city and rural area in city;Mycotoxin, excess addition food additives in food etc., have carcinogenic and promote Cancer is acted on;And some occupations can contact many kinds of chemical substances, due to the Long Term Contact of workman, the generation of occupational cancer can be caused.), can cause to dislike Property tumour the incidence of disease rise.Due to the development of medical science and technology, the prolongation of the average life span, aging population phenomenon is serious, and the elderly suffers from tumour Probability than the young National People's Congress, therefore, the overall tumor incidence in the whole world is persistently raised.
Issue according to tumour Register of China《2012 China's tumour registration annual reports》, China is per minute just to have 6 people to confirm as cancer, because of cancer death Probability is 12.94%, it means that may have a people to suffer from cancer in about having per 5, taking may have one per in 8 people People can die from cancer!It is lung cancer to occupy national malignant tumor morbidity primary.When the morning that tumour finds, organ local time, surgeon are also confined to Also have an opportunity by local excision and cleaning, the tumour " finishing off with one blow " of local development.But in fact, due to finding during preoperative clinical examination Small transfer, in one or two years of the part population after surgery excision, can shift again.Because this potential MET is present, if postoperative Not chemotherapy is not checked, then the probability of had postoperative recurrent tumor is just very high yet.And the postoperative chemotherapy of Advanced cancers, it is also very important auxiliary Treatment means.In a word, this systemic disease of malignant tumour, by the large unit of tumors destroyed of performing the operation, eliminates being dispersed in, fragmentary by chemotherapy Cancer cell, carries out general auxiliary treatment, extends the life cycle of patient, or even is cured.
It is most strong for eugonic killing functions of immunocytes due to it along with chemotherapeutic treatment, while the tumour cell of fast-growth is killed, Kill our original growth some cells quickly in vivo, such as hair follicle cell, the hematopoietic cell in gastrointestinal tract cell, hair, cause common Side effect be exactly vomit, suffer from diarrhoea, alopecia, anaemia, have a low resistance it is inferior.Side effect of the majority to chemotherapy is turned pale at the mention of the tiger, with fear.Thing In reality, about more than 75% patient understands different degrees of appearance Nausea and vomiting (CINV) during chemotherapy is carried out, and severe patient can also cause water electrolysis Matter is unbalance, nutritional deficiency, bone marrow suppression, resistance degradation, and inflammatory reaction (is such as generated heat), other internal organs toxicity etc., so that having to Stop chemotherapy, so as to reduce therapeutic effect.
At present clinically for the side effect brought with chemicotherapy, often with Chinese and Western medicine partner treatment.Two common medicine antiemetic mainly have dopamine to receive Body antagonist, 5-HT3 receptor antagonists, nk 1 receptor antagonist, glucocorticoid, antihistamine etc., but belong to symptomatic treatment, and have not With various side effects of degree.
The present invention is a kind of Chinese medicine composition, and is administered in external application mode, greatly facilitates and uses, the particularly party with an artificial organic whole, According to damage of the chemicotherapy to human body, to strengthen the body resistance to consolidate the constitution, strengthening the spleen and stomach, replenishing the vital essence and removing heat as basic principle, improve patient immunity of organisms, be allowed to Possess enough source of nutrition, eliminating pathogen to support vital qi is obvious to preventative vomiting and the equal effect of Delayed emesis.
Jing is retrieved, though there is many Chinese medicine preventing or arresting vomiting sides, is not had and this side's identical, and most of prescription is oral after decocting.And after chemicotherapy, absolutely Most of patient has different degrees of gastrointestinal reaction, oral difficult.Therefore, this exterior-applied prescription is we have developed, by sticking navel, is reached The purpose that preventing or arresting vomiting antiemetic, function of spleen and stomach regulating, righting are got rid of evils, mitigates the toxic and side effect during chemicotherapy as far as possible, accelerates sufferer rehabilitation.
In daily life, many people by bus, by ship during also can produce uncomfortable, such as dizzy, nausea, have a stomach upset, feel sense is told in generation With tell liquid, daily trip is produced frightened, directly affect work and healthy.Jing is tested, and effect same is notable after the deposited navel of we.
【The content of the invention】
It is an object of the invention to provide for the pharmaceutical composition for the treatment of vomiting, there is the vomiting phenomenon caused to various factors preferable town to tell work With.By topical administration, the GI irritation that oral drugs cause is reduced, to taking the same convenient use of patient of difficulty, and have stable blood Concentration.It is a further object of the present invention to provide the preparation method of the pharmaceutical composition.
The present invention the medicament selection root of large-flowered skullcap, dried orange peel, the coptis, caulis perllae, prepared RHIZOMA PINELLIZE without adju-vant, cloves, the Radix Astragali, Radix Glycyrrhizae, sun-dried ginseng, Poria cocos, evodia rutaecarpa, Ginger is combined, and makes each efficacy of drugs play synergy such that it is able to the vomiting phenomenon effectively during prevention and treatment chemicotherapy, function of spleen and stomach regulating, Righting is got rid of evils, replenishing the vital essence and removing heat, mitigates the toxic and side effect during chemicotherapy, accelerates to recover healthy.
In the pharmaceutical composition of the present invention, the tuber of pinellia is reused, take the effect of its eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass;The root of large-flowered skullcap, coptis heat-clearing are dry Wet, heat of getting rid of evils disappears feeling of fullness;Dried orange peel qi-regulating dissipate-swelling;The caulis perllae row taste stagnation of the circulation of vital energy, anti-vomiting;Ginseng reinforces vital energy, and reinforces the spleen to benefit the lung, and promotes the production of body fluid to quench thirst;Fourth Fragrant middle benefit gas drop is inverse, tonifies the kidney and support yang;Radix Astragali invigorating qi for strengthening superficies;Evodia rutaecarpa eliminating cold to stop pain, stopping nausea and vomiting by lowering the adverse flow of QI;Poria cocos beneficial spleen and stomach, antitoxic heart-soothing and sedative;Radix Glycyrrhizae is adjusted With all medicines.In order to obtain more preferably curative effect, the present invention can also add ginger on the basis of said medicine, ginger harmonizing stomach and lowering adverse Qi, surname dissipate aqueous vapor and the ruffian that disappears It is full.Full side's using warming and heat-clearing simultaneously, tonification and purgation in combination makes cold radiating clear, reconciles up and down, and lifting is multiple normal, then vomit self-healing.
The purpose of the present invention is realized by following technical measures rice:
A kind of pharmaceutical composition for treating vomiting effect, it is characterised in that be made up of the bulk drug of following weight portion:Root of large-flowered skullcap 5-20 parts, dried orange peel 5-20 Part, coptis 3-10 parts, caulis perllae 5-20 parts, prepared RHIZOMA PINELLIZE without adju-vant 5-20 parts, cloves 5-20 parts, raw Radix Astragali 10-40 parts, Radix Glycyrrhizae 3-10 parts, sun-dried ginseng 3-10 parts, Poria cocos 5-20 parts, evodia rutaecarpa 3-10 parts, described pharmaceutical composition formulation is external preparation.
It is preferred that being made up of the bulk drug of following weight portion:Root of large-flowered skullcap 8-15 parts, dried orange peel 8-15 parts, coptis 5-8 parts, caulis perllae 8-15 parts, prepared RHIZOMA PINELLIZE without adju-vant 8-15 Part, cloves 8-15 parts, raw Radix Astragali 15-30 parts, Radix Glycyrrhizae 5-8 parts, sun-dried ginseng 5-8 parts, Poria cocos 8-15 parts, evodia rutaecarpa 5-8 parts.
More preferably it is made up of the bulk drug of following weight portion:10 parts of the root of large-flowered skullcap, 0 part of dried orange peel, 6 parts of the coptis, 10 parts of caulis perllae, 10 parts of prepared RHIZOMA PINELLIZE without adju-vant, 10 parts of cloves, raw 20 parts of the Radix Astragali, 6 parts of Radix Glycyrrhizae, 6 parts of sun-dried ginseng, 10 parts of Poria cocos, 5 parts of evodia rutaecarpa.
Combination of the above thing may also include by weight ginger 5-20 parts, preferred 8-15 parts, more preferably 10 parts.
The bulk drug is the dry powder or extract of Chinese medicine, and extract is alcohol extracting thing or water extract, and more preferably extract is alcohol extract.
Described pharmaceutical composition formulation is gel, ointment, powder, pulvis, paste, patch, gel ointment.
This composition can be prepared in the following ways:
Weigh recipe quantity medicinal material, be ground into fine powder or be extracted into medicinal extract/liquid extract, using conventional formulation technologies make gel, ointment, powder, Pulvis, paste, patch, gel ointment.
【Specific embodiment】
In order that the purpose of the present invention, technical scheme and beneficial effect are of greater clarity, the present invention is made further in detail with reference to specific embodiment Describe in detail bright.It should be appreciated that specific embodiment described herein is only used for explaining the present invention, but it is understood not to have any restriction to the present invention.
The vomiting phenomenon that the present invention causes for a variety of causes, proposes a kind of pharmaceutical composition, and described pharmaceutical composition includes the raw material of following weight portion Medicine is made:Root of large-flowered skullcap 5-20 parts, dried orange peel 5-20 parts, coptis 3-10 parts, caulis perllae 5-20 parts, prepared RHIZOMA PINELLIZE without adju-vant 5-20 parts, cloves 5-20 parts, the raw Radix Astragali 10-40 parts, Radix Glycyrrhizae 3-10 parts, sun-dried ginseng 3-10 parts, Poria cocos 5-20 parts, evodia rutaecarpa 3-10 parts, described pharmaceutical composition is external preparation.
Above pharmaceutical composition may also include ginger 5-20 parts.Ginger is fresh ginger, is squeezed the juice after cleaning, is acted on after juice filtration.Once cannot be used up Fresh ginger juice can Cord blood, but should use as early as possible.
Specific implementation method is as follows:
Embodiment 1:
1) weigh root of large-flowered skullcap 50g, dried orange peel 100g, coptis 50g, caulis perllae 75g, prepared RHIZOMA PINELLIZE without adju-vant 100g, cloves 100g, raw Radix Astragali 50g, Radix Glycyrrhizae 25g, Sun-dried ginseng 50g, Poria cocos 50g, evodia rutaecarpa 50g, crush and cross 120 mesh sieves, obtain uniform pharmaceutical composition powder.
2) kaolin 50g, Sodium Polyacrylate 500g, gel aluminum hydroxide 30g, natrium adetate 4g is added to be stirred in glycerine 3000g mixed Close uniform, it is standby.
3) 400g polyvinyl alcohol partial alcoholysis thing heating for dissolving is added in 3950g water, polyvinylpyrrolidone 200g, tartaric acid 30g is added Stirring and dissolving obtains the transparent aqueous solution.
4) add above-mentioned glycerol mixture to be stirred mixing to uniform lotion is obtained in the aqueous solution, add 500g pharmaceutical composition powders, carry out Sufficiently mixing is uniform, is applied on non-woven fabrics, and coating weight is the every square meters of 1200g/, and surface recombination polypropylene transparent film is cut into 10cm*14cm The gel adhesive of specification, both.
Embodiment 2:
1) weigh root of large-flowered skullcap 50g, dried orange peel 125g, coptis 50g, caulis perllae 75g, prepared RHIZOMA PINELLIZE without adju-vant 125g, cloves 100g, raw Radix Astragali 50g, Radix Glycyrrhizae 25g, Sun-dried ginseng 50g, Poria cocos 50g, evodia rutaecarpa 50g, add the water of 10 times, 8 times, 8 times amounts, refluxing extraction 3 times 2 hours every time, to filter, Merging filtrate, is concentrated into the twice of medicinal material weight, obtains composition water extract.
2) kaolin 50g, Sodium Polyacrylate 600g, gel aluminum hydroxide 30g, natrium adetate 4g is added to be stirred in glycerine 3000g mixed Close uniform, it is standby.
3) 400g polyvinyl alcohol partial alcoholysis thing heating for dissolving is added in 1350g water, polyvinylpyrrolidone 200g, tartaric acid 30g is added Stirring and dissolving obtains the transparent aqueous solution.
4) add above-mentioned glycerol mixture to be stirred mixing to uniform lotion in the aqueous solution, add 2000g pharmaceutical composition water extracts, carry out Sufficiently mixing is uniform, is applied on non-woven fabrics, and coating weight is the every square meters of 1100g/, and surface recombination polypropylene transparent film is cut into 10cm*14cm The gel adhesive of specification.
Embodiment 3:
1) root of large-flowered skullcap 100g, dried orange peel 125g, coptis 100g, caulis perllae 100g, prepared RHIZOMA PINELLIZE without adju-vant 120g, cloves 50g, raw Radix Astragali 200g, Radix Glycyrrhizae are weighed 50g, sun-dried ginseng 50g, Poria cocos 50g, evodia rutaecarpa 50g, add the water of 12,10,8 times of amounts, refluxing extraction 3 times 2 hours every time, to filter, Merging filtrate is simultaneously concentrated into 1.5 times of medicinal material weight, obtains composition water extract.
2) glycerine 2500g is weighed, adds kaolin 50g, Sodium Polyacrylate 600g, aluminium hydroxide 30g, natrium adetate 4g to be stirred mixed Close uniform.
3) 2100g water is weighed, 400g polyvinyl alcohol partial alcoholysis things, and heating for dissolving is added.
4) in 1760g pharmaceutical compositions water extract, polyvinylpyrrolidone 200g, tartaric acid 30g stirring and dissolvings is added to obtain the transparent aqueous solution, It is then added to be stirred in above-mentioned polyvinyl alcohol water solution, obtains viscous solution, it is standby.
5) in above-mentioned viscous solution, add above-mentioned glycerol mixture to be stirred mixing to uniform lotion, be applied on non-woven fabrics, coating weight is 1300g/ Per square meter, surface recombination polypropylene transparent film is cut into the gel adhesive of 10cm*14cm specifications.
Embodiment 4:
1) root of large-flowered skullcap 50g, dried orange peel 125g, coptis 125g, caulis perllae 75g, prepared RHIZOMA PINELLIZE without adju-vant 100g, cloves 100g, raw Radix Astragali 50g, Radix Glycyrrhizae are weighed 25g, sun-dried ginseng 50g, Poria cocos 50g, evodia rutaecarpa 50g, add 75% ethanol of 6 times of amounts, refluxing extraction three times 2 hours every time, to filter, Merging filtrate is simultaneously concentrated into 1/3rd of medicinal material weight, obtains composition alcohol extract.
2) kaolin 50g, Sodium Polyacrylate 600g, aluminium hydroxide 30g, natrium adetate 4g is added to be stirred mixing in glycerine 2000g equal It is even.
3) addition 400g polyvinyl alcohol partial alcoholysis thing heating for dissolving in 2050g water, addition ginger juice (after fresh ginger cleaning, cut into slices, squeeze the juice, Use after ginger juice filtration) 1500g, add polyvinylpyrrolidone 200g, tartaric acid 30g stirring and dissolvings and obtain the uniform aqueous solution.
4) add above-mentioned glycerol mixture to be stirred mixing to uniform lotion in the aqueous solution, add 800g pharmaceutical composition alcohol extracts, carry out Sufficiently mixing makes uniformly, is applied on non-woven fabrics, and per square meter, surface recombination polypropylene transparent film is cut into 10cm*14cm size water-settings to 1200g/ Adhesive.
Embodiment 5:
1) root of large-flowered skullcap 100g, dried orange peel 100g, coptis 60g, caulis perllae 100g, prepared RHIZOMA PINELLIZE without adju-vant 100g, cloves 100g, raw Radix Astragali 200g, Radix Glycyrrhizae are weighed 60g, sun-dried ginseng 60g, Poria cocos 100g, evodia rutaecarpa 60g, 50% ethanol of 8,6,6 times of amounts of addition, refluxing extraction 3 times, 2 hours every time, Filtration, merging filtrate is simultaneously concentrated into 1/2nd of medicinal material weight, obtains composition alcohol extract.
2) kaolin 50g, Sodium Polyacrylate 600g, aluminium hydroxide 30g, natrium adetate 4g is added to be stirred mixing in glycerine 3000g equal It is even.
3) addition 400g polyvinyl alcohol partial alcoholysis thing heating for dissolving in 1550g water, addition ginger juice 1000g (after fresh ginger cleaning, section, Squeeze the juice, use after ginger juice filtration), add polyvinylpyrrolidone 200g, tartaric acid 30g stirring and dissolvings and obtain the uniform aqueous solution.
4) add above-mentioned glycerol mixture to be stirred mixing to uniform lotion in the aqueous solution, add 800g pharmaceutical composition alcohol extracts, carry out Sufficiently mixing makes uniformly, is applied on non-woven fabrics, and per square meter, surface recombination polypropylene transparent film is cut into 10cm*14cm size water-settings to 1200g/ Adhesive.
Embodiment 6:
1) root of large-flowered skullcap, dried orange peel, the coptis, caulis perllae, prepared RHIZOMA PINELLIZE without adju-vant, cloves, the raw Radix Astragali, Radix Glycyrrhizae, sun-dried ginseng, Poria cocos, evodia rutaecarpa, rhizoma zingiberis are weighed each Equal portions, crush and cross 120 mesh sieves, obtain uniform pharmaceutical composition powder.
2) take lanolin, albolene plus heat fusing, add above-mentioned fine powder to be simultaneously stirred continuously, add starch, zinc oxide stirring, cooling and obtain final product Paste.
Find when (5 people) is tested in carsick crowd, take aforementioned pharmaceutical compositions powder, be tuned into after pasty state with vinegar, be applied on adhesive plaster, in Before it is attached to by bus on navel, what all participations were tested does not occur per capita carsick symptom, and patient is very satisfied.
Separately there are 5 people to carry out test of the aforesaid paste for carsick symptom.Appropriate paste is taken, is put on adhesive plaster, be attached on navel before by bus, Only 1 people is slightly uncomfortable, and other 4 people are without the carsickness symptom such as nausea.
Chemotherapy patients and naval ship officers and men are carried out clinical verification confirmation by the externally-applied medicine composite according to obtained in the present invention:During cancer chemotherapy Patient's vomiting has significantly alleviation, has reached drug therapy purpose.The officers and men seasick to naval vessels significantly improve seasick n and V phenomenon, concrete statistics knot The following form of fruit.
Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4 Embodiment 5
Number of cases 150 150 168 125 145
It is effective 56 43 62 32 40
Effectively 79 96 88 84 93
It is invalid 15 11 18 9 12
It is efficient 90% 92.7% 89.3% 92.8% 91.7%
Clinical discrimination standard:
It is effective:Symptoms of emesis is all alleviated
Effectively:Vomiting phenomenon part is obviously improved
It is invalid:Vomiting phenomenon is without any improvement
The clinical observation time:12 hours after patch medicine
Case Sex distribution:The male sex 58%, and women 42%
Case age distribution:Less than 15 years old 5%, 15-35 year 25%, 35-50 year 23%, 50-65 year 40%, over-65s 7%.

Claims (10)

1. it is a kind of for treat vomiting effect pharmaceutical composition, it is characterised in that be made up of the bulk drug of following weight portion:Root of large-flowered skullcap 5-20 parts, dried orange peel 5-20 It is part, coptis 3-10 parts, caulis perllae 5-20 parts, prepared RHIZOMA PINELLIZE without adju-vant 5-20 parts, cloves 5-20 parts, raw Radix Astragali 10-40 parts, Radix Glycyrrhizae 3-10 parts, sun-dried Ginseng 3-10 parts, Poria cocos 5-20 parts, evodia rutaecarpa 3-10 parts.
2. the pharmaceutical composition described in claim 1, it is characterised in that be made up of the bulk drug of following weight portion:Root of large-flowered skullcap 8-15 parts, dried orange peel 8-15 parts, Coptis 5-8 parts, caulis perllae 8-15 parts, prepared RHIZOMA PINELLIZE without adju-vant 8-15 parts, cloves 8-15 parts, raw Radix Astragali 15-30 parts, Radix Glycyrrhizae 5-8 parts, sun-dried ginseng 5-8 Part, Poria cocos 8-15 parts, evodia rutaecarpa 5-8 parts.
3. the pharmaceutical composition described in claim 2, it is characterised in that be made up of the bulk drug of following weight portion:10 parts of the root of large-flowered skullcap, 0 part of dried orange peel, the coptis 6 parts, 10 parts of caulis perllae, 10 parts of prepared RHIZOMA PINELLIZE without adju-vant, 10 parts of cloves, raw 20 parts of the Radix Astragali, 6 parts of Radix Glycyrrhizae, 6 parts of sun-dried ginseng, 10 parts of Poria cocos, Wu 5 parts of the fruit of medicinal cornel.
4. the pharmaceutical composition described in claim 1-3, it is characterised in that the bulk drug is used as medicine for Chinese medicine dry powder or extract is used as medicine.
5. the pharmaceutical composition described in claim 4, it is characterised in that its extract is water extract or ethanol extract.
6. claim 1-3 described pharmaceutical composition, it is characterised in that the pharmaceutical dosage form is external preparation.
7. claim 6 described pharmaceutical composition, it is characterised in that the external preparation is gel ointment, powder, paste.
8. claim 1 described pharmaceutical composition, wherein also including ginger 5-20 parts.
9. claim 2 described pharmaceutical composition, wherein also including ginger 8-15 parts.
10. claim 3 described pharmaceutical composition, wherein also including 10 parts of ginger.
CN201510753750.0A 2015-10-30 2015-10-30 Medicine composition for treating vomit Pending CN106620585A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111467461A (en) * 2020-04-17 2020-07-31 南京市中西医结合医院 Acupoint application medicine for treating postoperative nausea and vomiting and using method thereof

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