CN106620243A - Extraction and separation process for rhizoma polygonati - Google Patents
Extraction and separation process for rhizoma polygonati Download PDFInfo
- Publication number
- CN106620243A CN106620243A CN201510734322.3A CN201510734322A CN106620243A CN 106620243 A CN106620243 A CN 106620243A CN 201510734322 A CN201510734322 A CN 201510734322A CN 106620243 A CN106620243 A CN 106620243A
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- CN
- China
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- rhizoma polygonati
- ethanol
- extraction
- filtrate
- powder
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- Pending
Links
- 238000000605 extraction Methods 0.000 title claims abstract description 10
- 238000000926 separation method Methods 0.000 title claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 24
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000000706 filtrate Substances 0.000 claims abstract description 16
- 239000000843 powder Substances 0.000 claims abstract description 16
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 8
- 150000004676 glycans Chemical class 0.000 claims abstract description 8
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 8
- 239000005017 polysaccharide Substances 0.000 claims abstract description 8
- 229930013686 lignan Natural products 0.000 claims abstract description 5
- 235000009408 lignans Nutrition 0.000 claims abstract description 5
- 150000005692 lignans Chemical class 0.000 claims abstract description 5
- 239000002244 precipitate Substances 0.000 claims abstract description 5
- 229930182490 saponin Natural products 0.000 claims abstract description 5
- 150000007949 saponins Chemical class 0.000 claims abstract description 5
- 238000010828 elution Methods 0.000 claims abstract description 4
- 239000003208 petroleum Substances 0.000 claims abstract description 4
- 239000011347 resin Substances 0.000 claims abstract description 4
- 229920005989 resin Polymers 0.000 claims abstract description 4
- 238000002137 ultrasound extraction Methods 0.000 claims abstract description 4
- 238000003809 water extraction Methods 0.000 claims abstract description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 6
- 229960004756 ethanol Drugs 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 241000756042 Polygonatum Species 0.000 claims description 4
- 235000017709 saponins Nutrition 0.000 claims description 4
- 229940022682 acetone Drugs 0.000 claims description 3
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 3
- 238000012869 ethanol precipitation Methods 0.000 claims description 3
- 238000000746 purification Methods 0.000 claims description 3
- 238000002604 ultrasonography Methods 0.000 claims description 3
- 235000008737 Polygonatum biflorum Nutrition 0.000 claims description 2
- 235000004506 Polygonatum multiflorum Nutrition 0.000 claims description 2
- 238000011161 development Methods 0.000 abstract description 9
- 239000003814 drug Substances 0.000 abstract description 8
- 230000036541 health Effects 0.000 abstract description 5
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 238000005238 degreasing Methods 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- 230000018109 developmental process Effects 0.000 description 7
- 239000000047 product Substances 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 5
- 239000002537 cosmetic Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241001468611 Polygonatum cyrtonema Species 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 230000004224 protection Effects 0.000 description 2
- 229930002600 steroidal saponin Natural products 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000234280 Liliaceae Species 0.000 description 1
- 238000012356 Product development Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000324 neuroprotective effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 150000005856 steroid saponins Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention relates to an extraction and separation process for rhizoma polygonati. The extraction and separation process comprises the following steps: (1) crushing dried raw rhizoma polygonati into rhizoma polygonati powder; (2) degreasing the crushed rhizoma polygonati powder by virtue of petroleum ether, so as to obtain degreased rhizoma polygonati powder; and (3) carrying out ultrasonic extraction on the degreased rhizoma polygonati powder by virtue of 75% ethanol: (a) concentrating filtrate, purifying the filtrate by virtue of macroporous adsorption resin, and carrying out ethanol gradient elution and concentration, so as to obtain rhizoma polygonati total lignan and rhizoma polygonati total saponin, and (b) carrying out water extraction on medicine residues to form filtrate and filter residues, abandoning the filter residues, concentrating the filtrate, adding ethanol to generate precipitates, collecting the precipitates, and sequentially washing by virtue of ethanol, absolute ethanol, acetone and diethyl ether, so as to obtain coarse rhizoma polygonati polysaccharide. The extraction separation process has the beneficial effects that the industrial production is easily realized, an extract is high in purity and yield and stable in quality and can meet requirements on medicinal development of rhizoma polygonati, the comprehensive utilization of rhizoma polygonati is increased, and the development and utilization values of rhizoma polygonati in the fields of medical treatment and health are increased.
Description
Technical field
The present invention relates to the extraction process of Chinese herbal medicine, refers in particular to a kind of extraction and separation process of Rhizoma Polygonati.
Background technology
Rhizoma Polygonati is Liliaceae Polygonatum herbaceos perennial, is the important Chinese medicine of China, and medication is with a long history.Rhizoma Polygonati
In containing various chemical compositions such as polysaccharide, steroidal saponin, lignanoid, with cardiovascular protection, hypoglycemic, neuroprotective, exempt from
The extensively pharmacological action such as epidemic disease regulation, antitumor, anti-bacteria and anti-virus.China's Rhizoma Polygonati aboundresources, because it has medicinal, edible, sight
Reward and its cosmetic values, market demand increasingly increases, and with good economic benefit, market prospect is very wide.But it is right at present
Rhizoma Polygonati technology for extracting effective component is concentrated mainly on polysaccharide and steroidal saponin, causes a large amount of wastes of Rhizoma Polygonati resource.And at present
The pharmacodynamicss and its Mechanism Study of Rhizoma Polygonati are also little, are widely present on market not through the Rhizoma Polygonati of deep processing, and are with Rhizoma Polygonati
The health product of raw material are more rare, for present situation, it is necessary to carry out deep development utilization to Rhizoma Polygonati, and the health-care effect for making Rhizoma Polygonati is obtained
To bigger performance.Therefore, it is the comprehensive development and utilization of preferably realizing Rhizoma Polygonati, with modem technology system, science
Research Rhizoma Polygonati is particularly important.
Hunan Province is one of main place of production of Polygonatum cyrtonema Hua, and aboundresources, storage capacity is big.If can strengthen to Rhizoma Polygonati resource
Develop, realize Chinese medicine plant, processing, marketing integration pattern, the healthy and rapid development, greatly of Rhizoma Polygonati industry can not only be promoted
It is big to drive Development of Local Economy, present situation of the modern society people to health product increase in demand is even more complied with, beneficial in China's tradition
Medicine goes to the world, and public health cause is significant.
The content of the invention
The purpose of the present invention is improved and innovated for shortcoming and problem present in background technology, there is provided Yi Zhongcong
The extraction and separation process of the Rhizoma Polygonati of Rhizoma Polygonati total lignans, saponins of rhizoma polygonati and coarse solomon's seal polysaccharide is extracted in Rhizoma Polygonati.
The present invention is comprised the following steps：
1st, first dry raw sealwort is crushed and Rhizoma Polygonati powder is obtained.
2nd, again with petroleum ether by crush the defat of Rhizoma Polygonati powder into defat Rhizoma Polygonati powder.
3 and then with 75% ethanol ultrasonic extraction defat Rhizoma Polygonati powder, filtrate and medicinal residues are formed, wherein：
1. by purification with macroreticular resin after described filtrate concentration, then concentrated after ethanol gradient elution, formed
Rhizoma Polygonati total lignans and saponins of rhizoma polygonati.
2. described medicinal residues Jing ultrasound water extractions re-form filtrate and filtering residue, and the filtering residue of formation is abandoned；The filtrate concentration of formation
After add ethanol precipitation, then collect precipitate washed with ethanol, dehydrated alcohol, acetone and ether successively, finally obtain Rhizoma Polygonati thick
Polysaccharide.
Raw sealwort raw material of the present invention is Polygonatum cyrtonema Hua.
Advantages of the present invention and beneficial effect：
Polysaccharide, steroid saponin, the stability of the active component of lignanoids to present invention process extraction is carried out
Investigate, including influence factor's test, accelerated test and long term test, meet safety, low toxicity, the low requirement of energy consumption.The present invention is easy to
Industrialized production, extract purity is high, and high income, steady quality can meet the drug development needs of Rhizoma Polygonati, improve Rhizoma Polygonati
Comprehensive utilization, enhances Rhizoma Polygonati in medical treatment and the value of exploiting and utilizing of healthcare field.
The present invention effectively develops the effective ingredient of Rhizoma Polygonati, and extract can be used to prevent cardiovascular and cerebrovascular disease, enhancing to exempt from
Epidemic disease power, improve learning capacity and improve the health food of memory, meet third generation functional food standard.Present invention achieves yellow
Essence comprehensive utilization development goal, single-throw enters many outputs, meets Sustainable Exploitation strategy, is conducive to environmental conservation.
Specific embodiment
For ease of understanding the present invention, embodiments of the invention are shown below is.But, the present invention can be with many different
Form is realizing, however it is not limited to embodiment described herein.On the contrary, the purpose for providing these embodiments is made to the present invention
Disclosure more it is thorough comprehensively.
Unless otherwise defined, the skill of the technical field of all of technology used herein and scientific terminology and the present invention
The implication that art personnel are generally understood that is identical.Term used in the description is intended merely to describe specific enforcement purpose, is not
It is intended to limit the present invention.
Embodiment：
As shown in figure 1, the present invention is comprised the following steps：
1st, first dry raw sealwort is crushed and Rhizoma Polygonati powder is obtained.
2nd, again with petroleum ether by crush the defat of Rhizoma Polygonati powder into defat Rhizoma Polygonati powder.
3 and then with 75% ethanol ultrasonic extraction defat Rhizoma Polygonati powder, filtrate and medicinal residues are formed, wherein：
1. by purification with macroreticular resin after described filtrate concentration, then concentrated after ethanol gradient elution, formed
Rhizoma Polygonati total lignans and saponins of rhizoma polygonati.
2. described medicinal residues Jing ultrasound water extractions re-form filtrate and filtering residue, and the filtering residue of formation is abandoned；The filtrate concentration of formation
After add ethanol precipitation, then collect precipitate washed with ethanol, dehydrated alcohol, acetone and ether successively, finally obtain Rhizoma Polygonati thick
Polysaccharide.
The wild Rhizoma Polygonati resource reserves of China are about 30,000,000 tons, only about 800,000 tons of medicinal sealwort annual requirement, Rhizoma Polygonati
About in 1000-2000 tons, development of resources has larger potentiality for overall year production and marketing.Wild resource is reduced year by year, and Rhizoma Polygonati is in medicinal side
Face is on the increase, and Rhizoma Polygonati is increasingly becoming the best-selling goods in market.Therefore, the deep processing of Efforts To Develop Rhizoma Polygonati auxiliary product has
Bright prospects.
Rhizoma Polygonati growth cycle length, limits throughput.Polygonatum medicine-food two-purpose kind, amount progressively expands, and edible white tiles goes out
Mouthful up to 40-50 unit/kilogram, Rhizoma Polygonati price on Market of Chinese Materia Medica was maintained at 7 yuan or so from -2000 years 1996, increased within 2003 years
12 yuan, 2009 are first up to 17-18, and steady-state growth from 2010 was up to 34 yuan until 2012, was now maintained at 30 yuan or so, and
In steady-state growth.Rhizoma Polygonati also exports to the states such as Korea, Japan, but medicine, health product and the cosmetics kind developed are limited.Cause
This, there is very big breach in Rhizoma Polygonati market demand.As wild resource is gradually decreased with Rhizoma Polygonati in medicine, health product, cosmetics
Deng the exploitation in field, Rhizoma Polygonati supply does not far reach demand on market, and in increase tendency.Therefore, further investigation exploitation is yellow
Smart product has great market demand space.
The present invention can promote each ring such as planting rhizoma polygonati, Rhizoma Polygonati comprehensive utilization of resources, the research and development of Rhizoma Polygonati drug and food cosmetics
The development of section, lifts whole Rhizoma Polygonati industrial chain level, creates huge economic benefit.Additionally, looking forward to for other Rhizoma Polygonati product developments
Industry provides abundant raw material, increases local farmers income, promotes people's employment.
Embodiment of the present invention is only the description carried out to the preferred embodiment of the present invention, not to the present invention
Spirit and scope are defined, and on the premise of without departing from design philosophy of the present invention, engineers and technicians are to this in this area
Various modifications and improvement that bright technical scheme is made, all should fall into protection scope of the present invention, the skill that the present invention is claimed
Art content, has all recorded in detail in the claims.
Claims (1)
1. a kind of extraction and separation process of Rhizoma Polygonati, it is characterised in that comprise the following steps：
1) first dry raw sealwort is crushed and Rhizoma Polygonati powder is obtained；
2) again with petroleum ether by crush the defat of Rhizoma Polygonati powder into defat Rhizoma Polygonati powder；
3) and then with 75% ethanol ultrasonic extraction defat Rhizoma Polygonati powder, filtrate and medicinal residues are formed, wherein：
1. by purification with macroreticular resin after described filtrate concentration, then concentrated after ethanol gradient elution, form Rhizoma Polygonati
Total lignans and saponins of rhizoma polygonati；
2. described medicinal residues Jing ultrasound water extractions re-form filtrate and filtering residue, and the filtering residue of formation is abandoned；Add after the filtrate concentration of formation
Enter ethanol precipitation, then collect precipitate and washed with ethanol, dehydrated alcohol, acetone and ether successively, finally obtain coarse solomon's seal polysaccharide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510734322.3A CN106620243A (en) | 2015-10-30 | 2015-10-30 | Extraction and separation process for rhizoma polygonati |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510734322.3A CN106620243A (en) | 2015-10-30 | 2015-10-30 | Extraction and separation process for rhizoma polygonati |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106620243A true CN106620243A (en) | 2017-05-10 |
Family
ID=58809932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510734322.3A Pending CN106620243A (en) | 2015-10-30 | 2015-10-30 | Extraction and separation process for rhizoma polygonati |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106620243A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983814A (en) * | 2015-06-29 | 2015-10-21 | 河南中医学院 | Pulsatilla chinensis extract and application thereof to preparation of drugs for preventing and treating pulmonary fibrosis |
| CN109320624A (en) * | 2018-09-17 | 2019-02-12 | 田金举 | A kind of extraction process of Rhizoma Polygonati extract |
| CN113817079A (en) * | 2021-11-11 | 2021-12-21 | 云南恩润生物科技发展有限公司 | Extraction method of polygonatum polysaccharide |
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| CN101181354A (en) * | 2007-11-26 | 2008-05-21 | 沈阳药科大学 | Fructus schizandrae chemical composition group extract and preparation technique |
| CN101837091A (en) * | 2010-03-17 | 2010-09-22 | 安徽师范大学 | Process for continuously extracting polygonatum saponin and polygonatum polysaccharose |
| CN103610917A (en) * | 2013-12-06 | 2014-03-05 | 安徽省应用技术研究院 | Comprehensive extraction method of rhizoma polygonati total saponins and polygahatous polysaccharides |
| CN104027374A (en) * | 2014-03-25 | 2014-09-10 | 广州医科大学附属第一医院 | Asarum total lignan extract and extraction method thereof, and application of asarum total lignan extract in preparation of drugs used for mitigating or inhibiting cough |
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2015
- 2015-10-30 CN CN201510734322.3A patent/CN106620243A/en active Pending
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983814A (en) * | 2015-06-29 | 2015-10-21 | 河南中医学院 | Pulsatilla chinensis extract and application thereof to preparation of drugs for preventing and treating pulmonary fibrosis |
| CN109320624A (en) * | 2018-09-17 | 2019-02-12 | 田金举 | A kind of extraction process of Rhizoma Polygonati extract |
| CN113817079A (en) * | 2021-11-11 | 2021-12-21 | 云南恩润生物科技发展有限公司 | Extraction method of polygonatum polysaccharide |
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Application publication date: 20170510 |