CN106619996A - Chinese patent medicine for nourishing blood for regulating menstruation and preparation process thereof - Google Patents
Chinese patent medicine for nourishing blood for regulating menstruation and preparation process thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses Chinese patent medicine for nourishing blood for regulating menstruation and a preparation process thereof. The Chinese patent medicine is mainly prepared from the following traditional Chinese medicinal materials in parts by mass: 80 to 130 parts of Chinese angelica, 50 to 100 parts of rehmannia root, 50 to 100 parts of peach seed, 50 to 100 parts of safflower, 80 to 130 parts of fructus aurantii, 50 to 100 parts of red paeony root, 80 to 130 parts of rhizoma chuanxiong, 50 to 100 parts of radix bupleuri, 80 to 130 parts of radix platycodi and 30 to 50 parts of liquorice root. The Chinese patent medicine for nourishing blood for regulating menstruation is reasonable in prescription, and is small in the amount and high in the quality of herbal medicine; the traditional Chinese medicinal materials generate a synergistic effect, so that a good effect of nourishing blood for regulating menstruation can be achieved.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese patent drug and its preparation technology of nourishing blood for regulating menstruation.
Background technology
Jing, pregnant, product, breast are the special physilogical characteristics of women, determine female pathology " based on blood, with blood as use ".Female
Property by blood-nourishing, the purpose of menstruation regulating, beauty can be reached.
Classification
Human body can form different types of physique due to the impact of native endowment difference and the condition day after tomorrow, from two sides of negative and positive
Face point has:Relatively YIN-deficiency type or relatively deficiency of yang type.
Two classes can also be substantially divided into according to menstruation:Oligomenorrhea or hyper-menorrhea.
Oligomenorrhea:Such as mistake after amenorrhoea, Hypomenorrhea, menstruation.
Nourishing blood for regulating menstruation belongs to yin-deficiency constitution person
Menstruation apolipsis more than 6 months;Or MBV is significantly reduced or menstrual period were less than 2 days;Or after menstrual period mistake more than more than seven days.Cheekbone
Red dry lip, dysphoria in chestpalms-soles, night sweat dry cough, tongue is red, few tongue, thready rapid pulse.
Classification:
Qi-deficiency type
Menstrual cycle easily shifts to an earlier date, menorrhagia, easy lassitude and weak, poor appetite, is often accompanied by that digestion function of stomach and intestine is bad or easy abdomen
The situation rushed down.It is pale, pale tongue, weak pulse.Appropriate to the occasion replenishing and restoring lung qi, and modest movement are treated, physical efficiency is tempered.
Menstruation regulating blood-deficiency type
Anaemia being suffered from the women of this kind of physique, Jing colors are thin, and quality is diluter, pale or sallow more, easily tired, dizzy,
Palpitaition, pale tongue, tongue is thin white, and arteries and veins is thin and delicate.Green vegetables or the apples such as lean meat, red phoenix dish or spinach, yam leaf should be eaten at ordinary times more
Really, the rich chalybeate food such as cherry, grape.Treat suitable tonifying Qi, blood-nourishing.
Menstruation regulating blood stasis type
Menstruation is easily delayed, and Jing amounts are very few or have clot, and menses color is purple or black dull, underbelly pain during menstrual onset, and clot is discharged
Afterwards pain somewhat mitigates, and severe patient is even infertile, is common in endometriosis patients.Treat appropriate to the occasion promoting blood circulation and removing blood stasis.
Menstruation regulating palace is trembled with fear type
This physique often betides the women that love eats cold food.Menstruation is easier to delay, Jing measure less or color it is dark, some
Before menstruation comes or carry out time of tide cold and pain in the lower abdomen, even blue in the face, cold limbs when violent, then pain can somewhat mitigate for hot compress.Examine
When examining, can often find that tongue color is thin, tongue fur is white, and arteries and veins Shen is tight.Control preferably warming channel and expelling cold, and the food for eating raw food should be avoided.
Menstruation regulating blood-heat type
Menstruation easily shifts to an earlier date, and Jing amounts are more, and quality is more sticky, at ordinary times easy restlessness and thirst, and face is easily rubescent, and leukorrhea Huang is thick different
Taste, tongue nature is partially red, and tongue fur is yellow.Except foreign genetic element, this kind of physique can sleep, stay up late because of long-term evening, or at ordinary times mood excessively swashs
It is dynamic, or like to eat caused by pungent food.Treat the solid Jing of appropriate to the occasion cool blood.The cooling food such as celery, lotus rhizome, sponge gourd can be eaten more
Thing, avoids and eats fried, pungent, stimulant, and go to bed before being suitable for 11 o'clock of evening.
Menstruation regulating phlegm-damp type
Fatter more than figure, chest tightness is swollen, and menstruation is easier to delay or Jing amounts are few, is often accompanied by the more situation of leukorrhea.Preferably many foods are white
The eliminating the phlegm such as radish, sea-tangle, water chestnut, wax gourd, sea cucumber, Hai Zhepi disappear the food of fat, eat that fat meat is fried to wait the food for encouraging phlegm wet less.
Overweight people preferably eats less and moves more, loses weight.
Menstruation regulating liver energy stagnation type
Menstrual cycle is more irregular, easy sentimental, irritable or emotional instability, the easy distending pain of breast before menstrual onset.Tongue
Side is dark, and tongue is thin white or thin Huang, veins string.It is common in premenstrual tension disease group.Treat suitable soothing liver-qi stagnation.
Menstruation regulating renal deficiency type
Often betide congenital constitution weak, during the non-full maturity of Development in Puberty, or over climacteric, have the confusion of the menstrual cycle,
The situations such as the soreness of waist is soft enough, dizziness and tinnitus, are clinically divided into " kidney-yin deficiency " and " kidney-yang deficiency " again.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine preparation safely, effectively, having no side effect.
It is a further object to provide the Chinese patent drug and its preparation technology of a kind of nourishing blood for regulating menstruation.
To achieve these goals, the present invention summarizes clinical experience composition effective formula and drug for many years according to theory of traditional Chinese medical science.
Its prescription is as follows:
80~130 parts of Radix Angelicae Sinensis, 50~100 parts of radix rehmanniae recen, 50~100 parts of peach kernel, 50~100 parts of safflower, 80~130 parts of Fructus Aurantii,
50~100 parts of the radix paeoniae rubrathe, 80~130 parts of Ligusticum wallichii, 50~100 parts of radix bupleuri, 80~130 parts of balloonflower root, 30~50 parts of Radix Glycyrrhizae.
The invention has the beneficial effects as follows:
1st, prescription of the invention is compared with the prescription for the treatment of similar disease at present, and reasonable recipe, flavour of a drug are fewer but better, and each medicine is produced
Synergy, can produce good treatment nourishing blood for regulating menstruation effect.
2nd, preparation process research and design of the invention is careful rationally, and pharmacodynamics has been formulated in combination with active component extraction
Technique, farthest removes impurity, it is ensured that the drug effect of prescription on the basis of good nourishing blood for regulating menstruation, treatment nourishing blood for regulating menstruation,
Injection volume is reduced again, is that the Study on Forming of preparation is laid a good foundation.
3rd, the present invention can also make dosage form series, including capsule, tablet, particle for treatment nourishing blood for regulating menstruation Chinese patent drug
Agent, soft capsule or other formulations etc..These formulations all have that easy to use, good stability, quality controllability be good, patient adapts to
The advantages of property is good.
Specific embodiment
With reference to embodiment, the present invention is further illustrated, but is not limited thereto.
Embodiment 1
One kind is used for nourishing blood for regulating menstruation Chinese patent drug, is made up of the Chinese medicine of following mass parts:80 parts of Radix Angelicae Sinensis, 100 parts of radix rehmanniae recen, peach kernel
100 parts, 100 parts of safflower, 130 parts of Fructus Aurantii, 100 parts of the radix paeoniae rubrathe, 80 parts of Ligusticum wallichii, 50 parts of radix bupleuri, 80 parts of balloonflower root, 30 parts of Radix Glycyrrhizae.
Embodiment 2
One kind is used for nourishing blood for regulating menstruation Chinese patent drug, is made up of the Chinese medicine of following mass parts:80 parts of Radix Angelicae Sinensis, 110 parts of radix rehmanniae recen, peach kernel
110 parts, 110 parts of safflower, 120 parts of Fructus Aurantii, 110 parts of the radix paeoniae rubrathe, 80 parts of Ligusticum wallichii, 60 parts of radix bupleuri, 80 parts of balloonflower root, 30 parts of Radix Glycyrrhizae.
Embodiment 3
One kind is used for nourishing blood for regulating menstruation Chinese patent drug, is made up of the Chinese medicine of following mass parts:100 parts of Radix Angelicae Sinensis, 120 parts of radix rehmanniae recen, peach
100 parts of benevolence, 120 parts of safflower, 130 parts of Fructus Aurantii, 100 parts of the radix paeoniae rubrathe, 90 parts of Ligusticum wallichii, 60 parts of radix bupleuri, 80 parts of balloonflower root, 30 parts of Radix Glycyrrhizae.
Embodiment 4
One kind is used for nourishing blood for regulating menstruation Chinese patent drug, is made up of the Chinese medicine of following mass parts:80 parts of Radix Angelicae Sinensis, 90 parts of radix rehmanniae recen, peach kernel
100 parts, 90 parts of safflower, 130 parts of Fructus Aurantii, 120 parts of the radix paeoniae rubrathe, 80 parts of Ligusticum wallichii, 80 parts of radix bupleuri, 90 parts of balloonflower root, 30 parts of Radix Glycyrrhizae.
A kind of preparation for nourishing blood for regulating menstruation capsule of embodiment 5
The Chinese patent drug of embodiment 1~4 can be made by a kind of nourishing blood for regulating menstruation capsule by following technique, be comprised the following steps that:
(1)Each medicine is weighed in proportion;
(2)All medicinal materials are added water to cook 2 times, decocting liquid, filtration, are stood, and take supernatant concentration to appropriate;
(3)Lactose, appropriate microcrystalline cellulose are added, are mixed, make particle, be dried, whole grain,
It is standby;
(4)Particle adds 1% magnesium stearate, 1% silica to mix, and filling capsule makes the Chinese patent drug for nourishing blood for regulating menstruation;
Using method:Orally.
A kind of preparation of nourishing blood for regulating menstruation piece of embodiment 6
The Chinese patent drug of embodiment 1~4 can be made by a kind of nourishing blood for regulating menstruation piece by following technique, be comprised the following steps that:
(1)Each medicine is weighed in proportion;
(2)All medicinal materials are added water to cook 2 times, decocting liquid, filtration, are stood, and take supernatant concentration to appropriate;
(3)Lactose, appropriate microcrystalline cellulose are added, are mixed, make particle, be dried, whole grain,
It is standby;
(4)Particle adds 1% magnesium stearate, 1% silica to mix, and compressing tablet makes the Chinese patent drug for nourishing blood for regulating menstruation;
Using method:Orally.
A kind of scattered preparation of the nourishing blood for regulating menstruation of embodiment 7
The Chinese patent drug of embodiment 1~4 can be made into a kind of nourishing blood for regulating menstruation and dissipated by following technique, comprise the following steps that:
(1)Each medicine is weighed in proportion;
(2)All medicinal materials are added water to cook 2 times, decocting liquid, filtration, are stood, and take supernatant concentration to appropriate;
(3)Lactose, appropriate microcrystalline cellulose are added, are mixed, make particle, be dry, pulverize,
It is standby;
(4)Fine powder adds 1% silica to mix, and the Chinese patent drug for nourishing blood for regulating menstruation is made in pack;
Using method:Warm water is taken after mixing it with water.
A kind of preparation of nourishing blood for regulating menstruation particle of embodiment 8
The Chinese patent drug of embodiment 1~4 can be made by a kind of nourishing blood for regulating menstruation particle by following technique, be comprised the following steps that:
(1)Each medicine is weighed in proportion;
(2)All medicinal materials are added water to cook 2 times, decocting liquid, filtration, are stood, and take supernatant concentration to appropriate;
(3)Lactose, appropriate microcrystalline cellulose are added, are mixed, make particle, be dried, whole grain,
It is standby;
(4)Particle adds 1% magnesium stearate, 1% silica to mix, and the Chinese patent drug for nourishing blood for regulating menstruation is made in pack;
Using method:Warm water is taken after mixing it with water.
A kind of preparation of nourishing blood for regulating menstruation soft capsule of embodiment 9
The Chinese patent drug of embodiment 1~4 can be made by a kind of nourishing blood for regulating menstruation soft capsule by following technique, be comprised the following steps that:
(1)Each medicine is weighed in proportion;
(2)All medicinal materials are added water to cook 2 times, decocting liquid, filtration, are stood, and take supernatant concentration to appropriate;
(3)It is dried, makes standby after fine powder;
(4)Appropriate soybean oil is added, is mixed, as content, prepare suitable rubber, soft capsule is made on encapsulating machine,
Make the Chinese patent drug of nourishing blood for regulating menstruation;
Using method:Warm water is taken after mixing it with water.
Claims (8)
1. a kind of Chinese patent drug for nourishing blood for regulating menstruation, it is characterised in that be mainly made up of the Chinese medicine of following mass parts:Radix Angelicae Sinensis 80
~130 parts, 50~100 parts of radix rehmanniae recen, 50~100 parts of peach kernel, 50~100 parts of safflower, 80~130 parts of Fructus Aurantii, the radix paeoniae rubrathe 50~100
Part, 80~130 parts of Ligusticum wallichii, 50~100 parts of radix bupleuri, 80~130 parts of balloonflower root, 30~50 parts of Radix Glycyrrhizae, add proper auxiliary materials system after extraction
Into 1000 parts.
2. the Chinese patent drug of nourishing blood for regulating menstruation according to claim 1, it is characterised in that the main Chinese medicine system by following mass parts
Into:80~100 parts of Radix Angelicae Sinensis, 50~80 parts of radix rehmanniae recen, 50~80 parts of peach kernel, 50~80 parts of safflower, 80~100 parts of Fructus Aurantii, the radix paeoniae rubrathe
50~80 parts, 80~100 parts of Ligusticum wallichii, 50~80 parts of radix bupleuri, 80~100 parts of balloonflower root, 30~50 parts of Radix Glycyrrhizae.
3. the Chinese patent drug of nourishing blood for regulating menstruation according to claim 2, it is characterised in that the main Chinese medicine by following mass parts
Make:80 parts of Radix Angelicae Sinensis, 100 parts of radix rehmanniae recen, 100 parts of peach kernel, 100 parts of safflower, 130 parts of Fructus Aurantii, 100 parts of the radix paeoniae rubrathe, 80 parts of Ligusticum wallichii, bavin
50 parts recklessly, 80 parts of balloonflower root, 30 parts of Radix Glycyrrhizae.
4. the Chinese patent drug according to any one of claims 1 to 3, it is characterised in that can also add pharmaceutically in the Chinese patent drug
The auxiliary material of permission makes oral formulations.
5. the preparation method of the Chinese patent drug of the nourishing blood for regulating menstruation described in any one of Claims 1 to 4, comprises the steps:
(1)Each medicine is weighed in proportion;
(2)All medicinal materials are added water to cook 2 times, decocting liquid, filtration, are stood, and take supernatant concentration to appropriate;
(3)Lactose, appropriate microcrystalline cellulose are added, is mixed, make particle, be dried, whole grain;
(4)By gained particle, appropriate silica, magnesium stearate are added, make the Chinese patent drug of nourishing blood for regulating menstruation.
6. preparation method according to claim 5, step(2)Characterized in that, the decocting for adopting boil the condition of technology for:
Plus 8~10 times of water, soak 0.5~1h.
7. preparation method according to claim 5, it is characterised in that step(2)The technical conditions of the decocting cooking method are:
Decoct 3 hours for the first time, decoct 2 hours for second, filtration, merging filtrate stands, take supernatant concentration to appropriate.
8. preparation method according to claim 5, it is characterised in that step(4)Concrete operations be:According to different agent
Type, using different auxiliary material, is mixed evenly to prepare suitable particulate, makes the Chinese patent drug of nourishing blood for regulating menstruation.
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CN115429837A (en) * | 2022-09-05 | 2022-12-06 | 厉小伟 | Foot health-care lotion |
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CN106176931A (en) * | 2016-08-31 | 2016-12-07 | 佛山市弘泰药物研发有限公司 | A kind of for blood circulation promoting and blood stasis dispelling, anginal Chinese patent medicine and preparation technology thereof |
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