CN108606992A - A kind of Chinese medicine preparation and preparation method thereof for treating puerperal spontaneous sweating - Google Patents
A kind of Chinese medicine preparation and preparation method thereof for treating puerperal spontaneous sweating Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A61K35/63—Arthropods
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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Abstract
The invention discloses a kind of Chinese medicine preparation and preparation method thereof for treating puerperal spontaneous sweating, the Chinese medicine preparation for treating puerperal spontaneous sweating is made of the component preparation of following parts by weight meter：59 parts of Radix Astragali, 24 parts of Rhizoma Atractylodis Macrocephalae, 35 parts of oyster, 15 parts of Chinese gall.The Chinese medicine preparation of the present invention has effects that invigorating qi for consolidating superficies hidroschesis, the spontaneous perspiration symptom of postpartum women can be effectively relieved, delay or control the progress of disease, clinical effectiveness is notable, can make up cannot effectively effect a radical cure merely the deficiency of puerperal spontaneous sweating with Western medicine, provide another new effective way for the treatment of puerperal spontaneous sweating, and drug effect is preferable, most of patient in three days can hidroschesis, suitable in clinical further genralrlization application.
Description
Technical field
The present invention relates to technical field of Chinese medicine more particularly to a kind of Chinese medicine preparation for treating puerperal spontaneous sweating and its preparation sides
Method.
Background technology
Many illnesss often occur for women's postpartum, and puerperal spontaneous sweating is most common one of which.When puerperal spontaneous sweating is because of production
It firmly exaggerates, qi and blood is lost excessive caused.Because the deficiency of vital energy then table it is not solid due to sweat from going out.Puerpera is more in perspiring in 2-3 days postpartum, is
Normal phenomenon should gradually decrease thereafter and stop.If puerpera's postpartum excessive sweating or perspiration overlong time and cannot be and dynamic from only
Then aggravate, foul wind, and complexion occur and whiten, shortness of breath lazyness speech, language is low fast, and indolent and listless weak, pale tongue, tongue is thin, deficient and weak pulse lamp symptom
Person, referred to as puerperal spontaneous sweating.Some women's postpartum sweating are more usually more, and especially to be to write after feed, activity or when sleeping, this is because of production
Afterwards caused by the rapid empty, interspaces of skin and muscles being loose of qi and blood, it can be sought after a couple of days and defend self-regulated and alleviate, not malingering opinion.Early in Han dynasty《Synopsis Golden Chamber》
In have the discussion of " blood deficiency just after delivery, hidrosis go out, being easily affected by apoplexy, therefore enable sick convulsion ", and " hidrosis goes out " is considered as the cause of disease of three disease of postpartum
One of interpretation of the cause, onset and process of an illness.Sui Dynasty《The General Treatise on the Cause and Symptoms of Diseases》First " continuous sweating after delivery time ", it is indicated that blood trouble causes " the cloudy deficiency of vital energy when cause of disease is predominantly produced
And yang-energy is in addition, interior deficiency table is real, and hyperactivity of YANG QI alone is in outer." the Tang Dynasty《It is precious through effect production》It is treated, is established for later age vertical with Modified Yupingfeng Powder
The prescription basis for the treatment of postpartum sweat disease.
Doctor trained in Western medicine has no specific medicament for puerperal spontaneous sweating at present, only carries out general drug symptomatic treatment, curative effect is simultaneously
It is undesirable, and there is certain side effect, pregnant woman is weaker in postpartum body, easy tos produce certain sequelae, generally not
It is recommended that taking treatment with western.
The Chinese invention patent of Publication No. CN101112547A discloses a kind of Chinese medicine preparation for treating puerperal spontaneous sweating, it
It is made of the bulk pharmaceutical chemicals that are matched following weight：Raw 1.5-6 parts of Radix Astragali, 1.0-4 parts of raw oyster, 1.0-4 parts of Radix Angelicae Sinensis, rhizoma atractylodis macrocephalae
1.5-6 parts, 1.0-4 parts of Fructus Tritici Levis, 0.1-2 parts of Schisandra chinensis, 1.5-6 parts of the tuber of dwarf lilyturf, 1.0-4 parts of radix pseudostellariae, honey-fried licorice root 0.1-2
It is part, 1.0-4 parts of spina date seed, 1.0-4 parts of radix ephedrae, 0.1-2 parts windproof；This formula uses ten several prescriptions, complex, prepares
Boil medicine and be more troublesome, and the medicine Time of Administration is long, as a treatment course with two weeks, three courses for the treatment of could cure, treatment cycle compared with
It is long.
Some current Chinese medicine preparations are complex, and the formula prescription content of Chinese medicine is more, and causing to make up a prescription is more troublesome；Due to
There's no such thing as a totally safe medicine in theory of traditional Chinese medical science takes excessive medicine in evil case, and therefore, a kind of Chinese medicine of simple good drug efficacy of invention is matched
Side, is of great significance.
Invention content
For overcome the deficiencies in the prior art, one of the objects of the present invention is to provide a kind of Chinese medicines for treating puerperal spontaneous sweating
Formula, the invention can solve the problems, such as that doctor trained in Western medicine drug effect is bad, Chinese medicine preparation is complicated.
The second object of the present invention is to provide a kind of preparation method of Chinese medicine preparation that treating puerperal spontaneous sweating.
An object of the present invention adopts the following technical scheme that realization：A kind of Chinese medicine preparation for treating puerperal spontaneous sweating, by such as
The component of lower parts by weight meter prepares composition：5-9 parts of Radix Astragali, 2-4 parts of Rhizoma Atractylodis Macrocephalae, 3-5 parts of oyster, 1-5 parts of Chinese gall.
Further, the Chinese medicine preparation of the treatment puerperal spontaneous sweating, the Chinese medicine preparation are made of following raw materials：Radix Astragali
3-6 parts, 2-3 parts of Rhizoma Atractylodis Macrocephalae, 3-5 parts of oyster, 2-4 parts of Chinese gall.
Further, the Chinese medicine preparation of the treatment puerperal spontaneous sweating, the Chinese medicine preparation are made of following raw materials：Radix Astragali
6 parts, 2.5 parts of Rhizoma Atractylodis Macrocephalae, 3.5 parts of oyster, 3 parts of Chinese gall.
Further, the Radix Astragali, Rhizoma Atractylodis Macrocephalae weight ratio be 6:2.5.
Further, the oyster, gallic weight ratio are 3.5:3.
Further, the Rhizoma Atractylodis Macrocephalae carries out bran stir-fry by stir-frying technique, and frying temperature setting is 130 DEG C -150 DEG C, frying
Time is set as 15min-20min, and taking-up after having fried weeds out honey wheat bran, for use.
The second object of the present invention adopts the following technical scheme that realization：A kind of preparation of Chinese medicine preparation that treating puerperal spontaneous sweating
Method, its step are as follows,
Step 1：By weight, take 1-5 parts of 5-9 parts of Radix Astragali, 2-4 parts of Rhizoma Atractylodis Macrocephalae, 3-5 parts of oyster, Chinese gall raw materials clear
It washes, is dried in shady place；
Step 2：The above-mentioned raw material cleaned is ground into 120 mesh fine powders using granular mill respectively, mixing is equal
It is even；
Step 3：The powder in step 2 is taken, 60-90 DEG C of boiling water is added, is uniformly mixed.
Further, in the Chinese medicine preparation preparation method of the treatment puerperal spontaneous sweating, the Rhizoma Atractylodis Macrocephalae passes through stir-frying technique
Bran stir-fry is carried out, frying temperature setting is 130 DEG C -150 DEG C, and the frying time is set as 15min-20min, and taking-up after having fried weeds out
Honey wheat bran, for use.
Further, powder is uniformly mixed with boiling water using ultrasonic wave in the step 3, condition setting is ultrasonic wave
Power 300W, ultrasonic time 10-15min.
The drug action mechanism of the present invention is as follows：
Radix Astragali is the root of legume Radix Astragali.Nature and flavor：Sweet, warm.Channel tropism：Return lung, the spleen channel.Major function：Invigorating qi for strengthening superficies, profit
Urinate eliminating toxic, apocenosis, expelling pus and promoting granulation.For treatment deficiency of vital energy weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency is certainly
Sweat, qi deficiency edema, ulcer is difficult to burst, burst for a long time and does not holds back, flaccidity of limbs due to deficiency of blood is yellow, Heat Diabetes；Chronic rephrilis protinuria, diabetes.To postpartum
The exterior deficiency spontaneous perspiration being led to because spleen-lung Qi deficiency is extremely suitable.(《Dictionary of medicinal plant》)
Rhizoma Atractylodis Macrocephalae is the rhizome of feverfew Rhizoma Atractylodis Macrocephalae.Nature and flavor：Bitter sweet, warm.Channel tropism：Enter spleen, stomach.Major function：Tonifying spleen, benefit
Stomach, eliminating dampness, and in, tocolysis.Control deficient QI of the spleen and stomach, do not feel like eating, burnout lacks gas, empty swollen, diarrhea, phlegm and retained fluid, oedema, jaundice, arthritis with fixed pain caused by dampness,
Difficult urination, dizzy, spontaneous perspiration, nausea are uneasy.The sweet temperature compensation spleen of this product, dispelling dampness with bitter and warm-natured drugs, the power that frying is drying damp and strengthening spleen win especially.It can assist
Radix Astragali benefiting qi for promoting production of blood.(《Dictionary of medicinal plant》)
Oyster is the shell of the long oyster of Ostreidae animal, ostrea talienwhanensis Crosse or Crassostrea rivularis.Nature and flavor：It is salty wet, it is cool.Channel tropism：
Enter liver and kidney channel.Major function：Hold back the moon, checking exuberance of yang, hidroschesis, puckery essence, resolving sputum, softening hard masses.Control frightened epilepsy, dizziness, spontaneous perspiration, night sweat, seminal emission,
Stranguria with turbid discharge, uterine bleeding, under, scrofula, goiter and tumor.For insomnia of palpitating with fear, dizziness and tinnitus, tuberculous lymphadenitis, lump in the abdomen lump in the abdomen, spontaneous sweating, seminal emission
Band is collapsed, pantothenic acid of having a stomachache.Calcined oyster shell restrains astringent method.For spontaneous sweating, band is collapsed in seminal emission, acid regurgitation of having a stomachache.(《Dictionary of medicinal plant》)
Chinese gall is the insect gall on Anacardiaceae plant Chinese sumac, potanin sumac or redpunjab sumac root leaf.Nature and flavor：Acid, temperature.Channel tropism：Enter
Lung, kidney channel, major function：It astringes the lung, nourshing kidney is promoted the production of body fluid, and sweat, puckery essence are received.It controls the deficiency syndrome of the lung to breath with cough, thirst, spontaneous perspiration, night sweat, internal lesion caused by overexertion
It is thin thin, emission, protracted dysentery and diarrhea.(《Dictionary of medicinal plant》)
Compared with prior art, the beneficial effects of the present invention are：
(1) Chinese medicine preparation of the invention meets the regulation of Pharmaceutical Administration Law of the People's Republic of China, stops with invigorating qi for consolidating superficies
The effect of sweat, can be effectively relieved the spontaneous perspiration symptom of postpartum women, delay or control the progress of disease, and clinical effectiveness is notable, can be more
The deficiency of puerperal spontaneous sweating cannot effectively be effected a radical cure merely with Western medicine by mending, and another new effective way is provided for the treatment of puerperal spontaneous sweating
Diameter, suitable in clinical further genralrlization application.
(2) Chinese medicine preparation of the invention can treat puerperal spontaneous sweating by less medicine, and effect harmless to the human body is prepared
It is convenient, it is convenient to take, it is cheap, mitigate the financial burden of patient.
Specific implementation mode
In the following, in conjunction with specific implementation mode, the present invention is described further, it should be noted that is do not collided
Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.
A kind of Chinese medicine preparation for treating puerperal spontaneous sweating, by weight, which is made of following raw materials：Radix Astragali 5-
9 parts, 2-4 parts of Rhizoma Atractylodis Macrocephalae, 3-5 parts of oyster, 1-5 parts of Chinese gall.
As preferred embodiment, by weight, which is made of following raw materials：3-6 parts of Radix Astragali, Rhizoma Atractylodis Macrocephalae
2-3 parts, 3-5 parts of oyster, 2-4 parts of Chinese gall.
As most preferred embodiment, by weight, which is made of following raw materials：6 parts of Radix Astragali, Rhizoma Atractylodis Macrocephalae
2.5 parts, 3.5 parts of oyster, 3 parts of Chinese gall.
As preferred embodiment, the Radix Astragali, Rhizoma Atractylodis Macrocephalae weight ratio be 6:2.5.
As preferred embodiment, the oyster, gallic weight ratio are 3.5:3.
As preferred embodiment, the Rhizoma Atractylodis Macrocephalae carries out bran stir-fry by stir-frying technique, and frying temperature setting is 130 DEG C-
150 DEG C, the frying time is set as 15min-20min, and taking-up after having fried weeds out honey wheat bran, for use.
A kind of preparation method of Chinese medicine preparation that treating puerperal spontaneous sweating, its step are as follows,
Step 1：By weight, take 1-5 parts of 5-9 parts of Radix Astragali, 2-4 parts of Rhizoma Atractylodis Macrocephalae, 3-5 parts of oyster, Chinese gall raw materials clear
It washes, is dried in shady place；
Step 2：The above-mentioned raw material cleaned is crushed into 120 mesh fine powders using granular mill respectively, is mixed
Uniformly；
Step 3：The powder in step 2 is taken, 60-90 DEG C of boiling water is added, is uniformly mixed, is taken.
As preferred embodiment, powder is uniformly mixed with boiling water using ultrasonic wave in the step 3, condition is set
It is set to ultrasonic power 300W, ultrasonic time 10-15min, is taken after the completion of ultrasound.Drug is mixed and is surpassed again
Sound so that the active ingredient in drug readily diffuses into water, it is easier to be absorbed by the body, accelerate treatment.
Embodiment 1-5 and comparative example 1-2
The proportioning according to the form below 1 weighs raw material respectively, is prepared in accordance with the following steps, the difference is that added
Raw material proportioning is different, prepares traditional Chinese powder medicine, specifically refers to table 1：
Table 1：Embodiment 1-5 and comparative example 1-2 raw material proportioning tables
Above-mentioned formula is prepared in accordance with the following steps：
Step 1：By weight, Radix Astragali, Rhizoma Atractylodis Macrocephalae, oyster, the cleaning of Chinese gall raw material are taken, is dried in shady place；
Step 2：The above-mentioned raw material cleaned is crushed into 120 mesh fine powders using granular mill respectively, is mixed
Uniformly；
Step 3：The powder in step 2 is taken, 60-90 DEG C of boiling water is added, is uniformly mixed using ultrasonic wave, condition setting
For ultrasonic power 300W, ultrasonic time 10-15min so that the active ingredient in drug readily diffuses into water, it is easier to
It is absorbed by the body, accelerates treatment, taken after the completion of ultrasound.
Confirmatory experiment example
Come the advantageous effect and safety evaluatio of the present invention is further explained the drug below by way of test example, these examinations
It includes clinical efficacy case to test example.
Powder of Chinese traditional medicine type made from the embodiment 1-5 of preparation and comparative example 1-2 is issued 300 puerperas, and (300 puerperas are equal
Have from dropping sweat endlessly, refreshing tired, weak, indigestion and loss of appetite, the symptom to be drunk yearningly) it takes, instructions of taking：Based on 1 number=5g, take each
Medicine is processed to get a daily dose according to above-mentioned preparation method, divides and take 3 times a day, take after the meal, three days as a treatment course.
The formula of comparative example 1-2 is identical as 3 preparation method of embodiment, and difference, which is only that on formula, lacks one group of medicine pair,
Remaining is identical, and instructions of taking is the same as embodiment 1-5.
Every group of embodiment has 50 to be taken from the puerpera person of dropping sweat endlessly, and blank control group has spontaneous perspiration leaching by 50 postpartum
It drenches endlessly, god is tired, weak, indigestion and loss of appetite, and the puerpera of the symptom to be drunk yearningly participates in statistics, takes effect assessment result such as table 2.
The clinical test results of table 2 embodiment 1-5 and comparative example 1-2
Note：Efficient %=(the number of+3-10 days hidroschesis of number of hidroschesis in 3 days)/every group of experiment number × 100%
Subject takes the traditional Chinese powder medicine of 1-5 of the embodiment of the present invention it can be seen from data in upper table, gives our conditioning
Afterwards, most subjects hidroschesis in 3 days, the subject 3-10 days hidroschesis in part, hidroschesis effective percentage reach 90% or more.It is especially real
Apply the optimal embodiment that example 3 is the present invention.
Compared with the identical comparative example 1-2 of the formula rate of most preferred embodiment 3, each leisure does not add two groups of medicines to (Radix Astragali
With Rhizoma Atractylodis Macrocephalae, oyster and Chinese gall) when, large effect is produced to its drug effect, hence it is evident that the effect for weakening postpartum hidroschesis is said
Two groups of medicines are illustrated to playing synergistic effect, i.e., Radix Astragali is shared with Rhizoma Atractylodis Macrocephalae in side, invigorating qi for strengthening superficies；Oyster is closed with Chinese gall
With convergence astringent method is used for spontaneous sweating.It adds medicine to after combined compatibility, has effects that invigorating qi for consolidating superficies hidroschesis, production can be effectively relieved
The spontaneous perspiration symptom of women afterwards, can fundamentally solve the problems, such as spontaneous perspiration, will not cause to recur after controlling, also further demonstrate formula
Reasonability.
The evaluation of safety
In clinical observation to randomly selected in experimental group 3 25 people carried out liver function test and blood routine before and after medication,
Routine urinalysis, gynaecological examination and ultrasound diagnosis adnexa uteria are checked, the results showed that pretherapy and post-treatment indices are equal in 25 patients
No abnormality seen illustrates that the preparation security obtained by embodiment 3 is good, while formula of the present invention also can be explained with good
Safety.
In addition, the preparation method of the present invention is simple, safe quick-acting is taken more healthy without adding additional additive.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,
The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed range.
Claims (9)
1. a kind of Chinese medicine preparation for treating puerperal spontaneous sweating, it is characterised in that：It is made of the component preparation of following parts by weight meter：It is yellow
5-9 parts of stilbene, 2-4 parts of Rhizoma Atractylodis Macrocephalae, 3-5 parts of oyster, 1-5 parts of Chinese gall.
2. the Chinese medicine preparation for the treatment of puerperal spontaneous sweating as described in claim 1, it is characterised in that：The Chinese medicine preparation is by following originals
Material is made：3-6 parts of Radix Astragali, 2-3 parts of Rhizoma Atractylodis Macrocephalae, 3-5 parts of oyster, 2-4 parts of Chinese gall.
3. the Chinese medicine preparation for the treatment of puerperal spontaneous sweating as described in claim 1, it is characterised in that：The Chinese medicine preparation is by following originals
Material is made：6 parts of Radix Astragali, 2.5 parts of Rhizoma Atractylodis Macrocephalae, 3.5 parts of oyster, 3 parts of Chinese gall.
4. the Chinese medicine preparation for the treatment of puerperal spontaneous sweating as described in claim 1, it is characterised in that：The weight of the Radix Astragali, Rhizoma Atractylodis Macrocephalae
Than being 6:2.5.
5. the Chinese medicine preparation for the treatment of puerperal spontaneous sweating as described in claim 1, it is characterised in that：It is the oyster, gallic heavy
Amount is than being 3.5:3.
6. the Chinese medicine preparation for the treatment of puerperal spontaneous sweating as described in any one in claim 1-5, it is characterised in that：The Rhizoma Atractylodis Macrocephalae passes through
The technique that stir-fries carries out bran stir-fry, and frying temperature setting is 130 DEG C -150 DEG C, and the frying time is set as 15min-20min, is taken after having fried
Go out, weeds out honey wheat bran, for use.
7. a kind of preparation method of Chinese medicine preparation that treating puerperal spontaneous sweating, it is characterised in that：Its step are as follows,
Step 1：By weight, 1-5 parts of 5-9 parts of Radix Astragali, 2-4 parts of Rhizoma Atractylodis Macrocephalae, 3-5 parts of oyster, Chinese gall raw material cleanings are taken, in
Shady place is dried；
Step 2：The above-mentioned raw material cleaned is ground into 120 mesh fine powders using granular mill respectively, is uniformly mixed；
Step 3：The powder in step 2 is taken, 60-90 DEG C of boiling water is added, is uniformly mixed.
8. the Chinese medicine preparation preparation method for the treatment of puerperal spontaneous sweating as claimed in claim 7, it is characterised in that：The Rhizoma Atractylodis Macrocephalae passes through
The technique that stir-fries carries out bran stir-fry, and frying temperature setting is 130 DEG C -150 DEG C, and the frying time is set as 15min-20min, is taken after having fried
Go out, weeds out honey wheat bran, for use.
9. the preparation method of the Chinese medicine preparation for the treatment of puerperal spontaneous sweating as claimed in claim 7, it is characterised in that：The step 3
Middle to be uniformly mixed powder using ultrasonic wave with boiling water, condition setting is ultrasonic power 300W, ultrasonic time 10-15min.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1915288A (en) * | 2006-08-25 | 2007-02-21 | 袁爱仙 | Medication for pasting on umbilicus to treat spontaneous sweating disease in dryness-heat scorching the lung type |
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2018
- 2018-06-21 CN CN201810643328.3A patent/CN108606992A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1915288A (en) * | 2006-08-25 | 2007-02-21 | 袁爱仙 | Medication for pasting on umbilicus to treat spontaneous sweating disease in dryness-heat scorching the lung type |
Non-Patent Citations (2)
| Title |
|---|
| 梁勇才: "《妇科诊治精要》", 28 February 1999, 人民军医出版社 * |
| 邢志敏等: "敛汗散敷脐治疗慢性心力衰竭自汗症35例", 《河南中医》 * |
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Effective date of registration: 20210129 Address after: Room 507, 5th floor, Xixi Hotel, building 1, Xixi No.1 creative business center, 808 wenerxi Road, Xihu District, Hangzhou, Zhejiang 310000 Applicant after: Hangzhou Xiyue maternal and Child Service Co.,Ltd. Address before: Room 2301-10, building 3, Xingyao City, 2028 Jiangling Road, Xixing street, Binjiang District, Hangzhou City, Zhejiang Province 310000 Applicant before: ZHEJIANG MEILIHE BIOTECHNOLOGY Co.,Ltd. |
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