CN106619438A - Plant-derived antibacterial agent and liquid soap and toothpaste with plant-derived antibacterial agent - Google Patents
Plant-derived antibacterial agent and liquid soap and toothpaste with plant-derived antibacterial agent Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Abstract
The invention relates to the field of plant antibacterial technologies, in particular to a plant-derived antibacterial agent and liquid soap and toothpaste with the plant-derived antibacterial agent. The plant-derived antibacterial agent comprises traditional Chinese medicine extract including, by weight, 30%-90% of pericarpium granati extract, 5%-30% of radix et rhizoma rhei extract, 5%-20% of radix sophorae flavescentis extract, 1%-10% of radix paeoniae alba extract, 1%-10% of olea europaeal extract and 0.01%-5% of propolis extract. The plant-derived antibacterial agent, the liquid soap and the toothpaste have the advantages that gram-positive bacteria, gram-negative bacteria, saccharomyces and anaerobic bacteria can be inhibited by the plant-derived antibacterial agent, the plant-derived antibacterial agent is wide in antibacterial spectrum and can be applied to the toothpaste and the liquid soap, excellent antiseptic effects can be realized, usage of chemically synthesized antiseptics can be reduced, accordingly, irritation of products can be reduced, and the safety of the products can be improved.
Description
Technical field
The present invention relates to plants antimicrobial technical field, and in particular to a kind of plant-based bacteriostat and washing containing the bacteriostatic agent
Hand liquid and toothpaste.
Background technology
As the improvement of people's living standards, the species of washing product are more and more, people want to washing product effect
Seek also more and more higher, it is more and more diversified, wherein to the demand of antibiotic effect be it is most basic be also the most important.
Wash in shield product usually added with antiseptic, product not microbial contamination is on the one hand prevented, on the other hand in people
Also function to antibiotic effect during use, but these are often based on the antiseptic of chemical synthesis, because the antibacterial of chemical synthesis
Agent good anti-bacterial effect and easily production, low price, but the antiseptic of chemical synthesis easily make people produce the pairs such as allergic reaction
Effect endangers the health of people, therefore people start to be more prone to using shield product is washed containing natural antimicrobial substance, and it is more
Plus it is safe and non-stimulated.
Natural antibacterial agent does not cause drug induced disease and restraining and sterilizing bacteria effect is bright without the resistance to the action of a drug, noresidue, non-environmental-pollution
It is aobvious, there is unique advantage in washing product and oral-cavity article, the security of washing product and skin care item had both been can ensure that, again may be used
For washing product of the exploitation with antibiotic effect and skin care item.In the long term, natural plant extracts substitute chemical synthesis
Antiseptic has vast potential for future development.
The content of the invention
In order to overcome shortcoming and defect present in prior art, it is an object of the invention to provide a kind of plant source is antibacterial
Agent, can suppress gram-positive bacteria, Gram-negative bacteria, saccharomycete and anaerobic bacteria, with wider antimicrobial spectrum.
Another goal of the invention of the present invention is to provide a kind of hand cleanser containing plant-based bacteriostat, with good anti-corrosion
Effect, can reduce the consumption of chemical synthesis preservative, so as to reduce the excitant of product, improve the security of product.
Another goal of the invention of the present invention is to provide a kind of toothpaste containing plant-based bacteriostat, with good anti-corrosion effect
Really, the consumption of chemical synthesis preservative can be reduced, so as to reduce the excitant of product, the security of product is improved.
The purpose of the present invention is achieved through the following technical solutions：
A kind of plant-based bacteriostat, the Chinese medical extract comprising following percentage by weight：
Pomegranate rind extract 30%～90%
Chinese rhubarb extract 5%～30%
Shrubby sophora extract 5%～20%
Radix paeoniae alba extraction 1%～10%
Olive leaf P.E 1%～10%
Propolis extract 0.01%～5%
Wherein, the mass percent sum of above-mentioned raw materials is 100%.
Wherein, the pomegranate rind extract, Chinese rhubarb extract, shrubby sophora extract, radix paeoniae alba extraction, Olive leaf P.E,
Propolis extract is obtained using organic solvent extraction：After Chinese medicine material is crushed, with 20-70% Extraction solvent refluxing extractions
2.5-3.5h, 20-70% Extraction solvent refluxing extractions 1.5-2.5h are used again after filtration by residue, are filtered, merging filtrate, by filtrate
After concentrated, with macroporous resin adsorption, with the ethanol elution of 30-70%, eluent is collected, reduced pressure concentration is obtained extract.
Wherein, the addition of each solvent is 8-10 times of traditional Chinese medicine extraction raw material gross weight during the solvent extraction.
Wherein, model D101 of the macroreticular resin.
Wherein, the pomegranate rind extract ethanol elution of 50-60%；The Chinese rhubarb extract ethanol elution of 60-70%；
The shrubby sophora extract ethanol elution of 50-60%；The radix paeoniae alba extraction ethanol elution of 40-50%；Olive leaf P.E 30-
40% ethanol elution；The propolis extract ethanol elution of 50-60%.
Wherein, the plant-based bacteriostat quality being concentrated under reduced pressure to give is 0.5-5 times of Chinese medicine material.
It is a kind of containing plant-based bacteriostat hand cleanser, be made up of the raw material of following mass percent：
Sodium sulfate of polyethenoxy ether of fatty alcohol emulsion 11.6%
Cocoanut fatty acid diethanolamide 2.0%
Glycerine 2.5%
Glycine betaine 3.0%
Bay both sexes sodium acetate 2.0%
Disodium ethylene diamine tetraacetate 0.1%
Citric acid 0.12%
Sodium chloride 0.5%
Deionized water surplus,
Wherein, the mass concentration of the sodium sulfate of polyethenoxy ether of fatty alcohol emulsion is 70%, and the mass concentration of the glycine betaine is
35%。
A kind of toothpaste containing plant-based bacteriostat, is made up of the raw material of following mass percent：
Saccharin sodium 0.1%
Xylitol 0.2%
Lauryl sodium sulfate 1.2%
Sodium lauroyl sarcosine 0.5%
Glycerine 18.0%
Sorbierite 10.0%
Xanthans 0.75%
Sanlose 0.45%
Calcium monohydrogen phosphate 50%
Sodium pyrophosphate 0.5%
Deionized water surplus.
The beneficial effects of the present invention is：The plant-based bacteriostat of the present invention can suppress gram-positive bacteria, gram-negative
Property bacterium, saccharomycete and anaerobic bacteria, with wider antimicrobial spectrum.Material of the compound without chemical synthesis, has no toxic side effect, skin
Skin excitant is little, stable in properties, safe and reliable.In addition, pomegranate rind extract is in addition to antibacterial effect, also with anti-inflammatory,
Treatment is scalded, effect of canker sore；Chinese rhubarb extract in addition to antibacterial effect, also with hemostasia effect；Kuh-seng is extracted
Thing in addition to antibacterial effect, also with anti-inflammatory, hemostasia effect；Radix paeoniae alba extraction also has in addition to antibacterial effect
Whitening, analgesic effect；Olive leaf P.E in addition to antibacterial effect, also with very strong anti-oxidation efficacy；Propolis is carried
Thing is taken in addition to antibacterial effect, also there is anti-inflammatory, anti-oxidant, beautifying face and moistering lotion.So, the plant source suppression of the present invention
Microbial inoculum is in addition to antimicrobial preservative efficacy, while have effect of anti-inflammatory, anti-oxidant, hemostasis, whitening and skin-protecting and beautifying face and moistering lotion, this
It is that chemical synthesis preservative institute is incomparable.
Specific embodiment
For the ease of the understanding of those skilled in the art, with reference to embodiment, the present invention is further illustrated, real
The content that the mode of applying is referred to not limitation of the invention.
Embodiment 1
A kind of plant-based bacteriostat is made up of by weight percentage following Chinese medical extract：
Pomegranate rind extract 50.5%
Chinese rhubarb extract 27.3%
Shrubby sophora extract 10.5%
Radix paeoniae alba extraction 4.5%
Olive leaf P.E 6.2%
Propolis extract 1.0%,
The pomegranate rind extract, Chinese rhubarb extract, shrubby sophora extract, radix paeoniae alba extraction, Olive leaf P.E, propolis extract
Obtained using organic solvent extraction：After Chinese medicine material is crushed, with 20% Extraction solvent refluxing extraction 2.5h, incite somebody to action after filtration
Residue is filtered, merging filtrate again with 20% Extraction solvent refluxing extraction 1.5h, by concentrating filter liquor after, with macroporous resin adsorption,
With 30% ethanol elution, eluent is collected, reduced pressure concentration is obtained extract.
The addition of each solvent is 8 times of traditional Chinese medicine extraction raw material gross weight during the solvent extraction.
Model D101 of the macroreticular resin.
The pomegranate rind extract with 50% ethanol elution；Chinese rhubarb extract with 60% ethanol elution；Shrubby sophora extract
With 50% ethanol elution；Radix paeoniae alba extraction with 50% ethanol elution；Olive leaf P.E with 40% ethanol elution；Propolis is carried
Take the ethanol elution that thing is with 60%.
The plant-based bacteriostat quality being concentrated under reduced pressure to give is 0.5 times of Chinese medicine material.
Embodiment 2
A kind of plant-based bacteriostat is made up of by weight percentage following Chinese medical extract：
Pomegranate rind extract 54.4%
Chinese rhubarb extract 18.2%
Shrubby sophora extract 13.5%
Radix paeoniae alba extraction 7.8%
Olive leaf P.E 5.6%
Propolis extract 0.5%,
The pomegranate rind extract, Chinese rhubarb extract, shrubby sophora extract, radix paeoniae alba extraction, Olive leaf P.E, propolis extract
Obtained using organic solvent extraction：After Chinese medicine material is crushed, with 70% Extraction solvent refluxing extraction 3.5h, incite somebody to action after filtration
Residue is filtered, merging filtrate again with 70% Extraction solvent refluxing extraction 2.5h, by concentrating filter liquor after, with macroporous resin adsorption,
With 70% ethanol elution, eluent is collected, reduced pressure concentration is obtained extract.
The addition of each solvent is 10 times of traditional Chinese medicine extraction raw material gross weight during the solvent extraction.
Model D101 of the macroreticular resin.
The pomegranate rind extract with 60% ethanol elution；Chinese rhubarb extract with 70% ethanol elution；Shrubby sophora extract
With 60% ethanol elution；Radix paeoniae alba extraction with 400% ethanol elution；Olive leaf P.E with 40% ethanol elution；Propolis is carried
Take the ethanol elution that thing is with -60%.
The plant-based bacteriostat quality being concentrated under reduced pressure to give is 5 times of Chinese medicine material.
Embodiment 3
A kind of plant-based bacteriostat is made up of by weight percentage following Chinese medical extract：
Pomegranate rind extract 66.4%
Chinese rhubarb extract 11.3%
Shrubby sophora extract 15.7%
Radix paeoniae alba extraction 3.4%
Olive leaf P.E 3.1%
Propolis extract 0.1%,
The pomegranate rind extract, Chinese rhubarb extract, shrubby sophora extract, radix paeoniae alba extraction, Olive leaf P.E, propolis extract
Obtained using organic solvent extraction：After Chinese medicine material is crushed, with 40% Extraction solvent refluxing extraction 3h, will be residual after filtration
Slag is filtered, merging filtrate again with 40% Extraction solvent refluxing extraction 2h, by concentrating filter liquor after, with macroporous resin adsorption, use 50%
Ethanol elution, collect eluent, reduced pressure concentration is obtained extract.
The addition of each solvent is 9 times of traditional Chinese medicine extraction raw material gross weight during the solvent extraction.
Model D101 of the macroreticular resin.
The pomegranate rind extract with 55% ethanol elution；Chinese rhubarb extract with 65% ethanol elution；Shrubby sophora extract
With 55% ethanol elution；Radix paeoniae alba extraction with 45% ethanol elution；Olive leaf P.E with 35% ethanol elution；Propolis is carried
Take the ethanol elution that thing is with 55%.
The plant-based bacteriostat quality being concentrated under reduced pressure to give is 2 times of Chinese medicine material.
Embodiment 4
A kind of plant-based bacteriostat is made up of by weight percentage following Chinese medical extract：
Pomegranate rind extract 63.9%
Chinese rhubarb extract 13.5%
Shrubby sophora extract 12.5%
Radix paeoniae alba extraction 2.3%
Olive leaf P.E 7.6%
Propolis extract 0.2%,
The pomegranate rind extract, Chinese rhubarb extract, shrubby sophora extract, radix paeoniae alba extraction, Olive leaf P.E, propolis extract
Obtained using organic solvent extraction：After Chinese medicine material is crushed, with 50% Extraction solvent refluxing extraction 3.5h, incite somebody to action after filtration
Residue is filtered, merging filtrate again with 55% Extraction solvent refluxing extraction 2.5h, by concentrating filter liquor after, with macroporous resin adsorption,
With 60% ethanol elution, eluent is collected, reduced pressure concentration is obtained extract.
The addition of each solvent is 10 times of traditional Chinese medicine extraction raw material gross weight during the solvent extraction.
Model D101 of the macroreticular resin.
The pomegranate rind extract with 60% ethanol elution；Chinese rhubarb extract with 60% ethanol elution；Shrubby sophora extract
With 60% ethanol elution；Radix paeoniae alba extraction with 40% ethanol elution；Olive leaf P.E with 40% ethanol elution；Propolis is carried
Take the ethanol elution that thing is with 50%.
The plant-based bacteriostat quality being concentrated under reduced pressure to give is 3 times of Chinese medicine material.
Antibacterial activity is tested
This experiment is by further by testing the suppression of the antiseptic for preparing of above three embodiment and single plant extract
Bacterium effect.Bacterial classification is wherein adopted for bacillus subtilis（Bacillus subtilis）ATCC6633, Escherichia coli
（Escherichia coli）ATCC8739, staphylococcus aureus（Staphylococcus aureus）ATCC6538, copper
Green pseudomonad（Pseudomonas aeruginosa）ATCC9027, Candida albicans（Canidia albicans）
ATCC10231, Streptococcus mutans（Streptococcus mutans）ATCC25175, porphyromonas gingivalis
（Porphyromonas gingivalis）ATCC33277.
Inhibition zone is determined：Using filter paper enzyme, the diameter d (mm) of inhibition zone is measured using crossing method with ruler.Its
In, aerobic bacteria is completed on superclean bench, and anaerobic bacteria completes in anaerobism work box.Fungistatic effect experiment is shown in Table shown in 1.
Table 1：The bacteriostatic activity of plant-based bacteriostat（Filter paper enzyme, d (mm)）
From table 1, above plant extracts is for typical gram-positive bacterium（Staphylococcus aureus and withered grass gemma
Bacillus）And oral cavity anaerobium（Streptococcus mutans and porphyromonas gingivalis）With stronger bacteriostatic activity, pomegranate rind extract
With propolis extract also to gramnegative bacterium（Escherichia coli and pseudomonas aeruginosa）Also have with Candida albicans certain
Inhibitory action.Simultaneously plant-based bacteriostat bacteriostasis compound as can be seen from the table is significantly better than folk prescription extract.
Minimal inhibitory concentration（MIC）Determine：Determined using agar dilution, completely inhibit the minimum extract of bacterial growth
Concentration is extract to for the MIC MIC of examination bacterium.Experimental result is shown in Table 2.
Table 2：The minimal inhibitory concentration of plant-based bacteriostat（MIC, %）
From table 2, plant-based bacteriostat is for typical gram-positive bacterium（Staphylococcus aureus and bacillus subtilis
Bacterium）And oral cavity anaerobium（Streptococcus mutans and porphyromonas gingivalis）With stronger bacteriostatic activity, its MIC
（MIC）Respectively 0.01%, 0.01%, 0.05%, 0.05%；To gramnegative bacterium（Escherichia coli and pseudomonas aeruginosa）With
Candida albicans also has certain inhibitory action, its MIC（MIC）Respectively 0.5%, 0.5%, 0.1%.While from
Can still show that compound plant-based bacteriostat bacteriostasis is significantly better than folk prescription extract in table.
Preservation challenge test of the plant-source antibacterial agent in hand cleanser
Using preservation challenge method of testing, reference《Chinese Pharmacopoeia》Microbial Challenge test method is tested.Test strain bag
Include Escherichia coli（E. coli）ATCC8739, staphylococcus aureus（S. aureus）ATCC6538, pseudomonas aeruginosa（P.
aeruginosa）ATCC9027, Candida albicans（C. albicans）ATCC10231, aspergillus niger（A. niger）
ATCC16404.With the hand cleanser in table 3 as sample test matrix.Before carrying out antimicrobial preservation challenge test, determination sample it is thin
Bacterium, mould bacterial content, it is ensured that its numerical value is less than 10 cfu/g.
Table 3：Hand sanitizer formula
Method of testing：Take the g of hand cleanser 20 and be divided into four groups for totally 8 parts, the bacterium mixing of 200 μ L is separately added into per group of 2 parts of samples
Liquid and mycotic spore suspension, make to be reached following level by the final bacteria containing amount of sample product：Bacterium 3.0 × 106 ~ 3.0 × 107
The cfu/g and cfu/g of mould 1.0 × 104 ~ 1.0 × 105, fully mixes.By sample under the conditions of 25 DEG C, after bacterium is connect
The d sample analysis of 0th, 7,14,21 and 28, by agar plate method the bacteria containing amount in sample is calculated.
Table 4：Results of preservation challenge tests in hand cleanser
Remarks："+" indicates that a large amount of bacterium colonies occur in table.First group：Not adding preservative agent；Second group：The nipalgin for plus 0.05%
Propyl ester；3rd group：The plant-based bacteriostat for plus 1.0%；4th group：The plant source suppression of the propylben+0.5% for plus 0.05%
Microbial inoculum.
Result judgement standard：In 7 d, bacterium and fungi count decline respectively in 99.9% and 90%, and 28 d and present continuously
Downward trend, then be considered as antiseptic effect excellent.Experimental result is shown in Table shown in 4.First group of non-adding preservative agent, without antibacterial effect
Really；Second and third, four groups all passed through preservation challenge test.Second group adds the Kathon CG preservative commonly used in daily chemical products,
Bacterial concentration is reduced to 230 cfu/g by interior energy in the microorganism of 106-107cfu/g within 7 days, by mold concentrations in 104-
The microorganism of 105cfu/g is reduced to 20 cfu/g；3rd group has added plant-based bacteriostat, and the effect of antibacterial is suitable with second group,
Bacterium is reduced into 350 cfu/g, mould is reduced into 20 cfu/g, it can be seen that the plant-based bacteriostat of the present invention really can
Play antisepsis；4th group because adding conventional Kathon CG preservative and plant-based bacteriostat, microorganism drops in interior energy within 7 days
It is low to 190 cfu/g, mould is reduced into 10 cfu/g.
Preservation challenge test of the plant-source antibacterial agent in toothpaste
Using preservation challenge method of testing, reference《Chinese Pharmacopoeia》Microbial Challenge test method is tested.Test strain bag
Include Streptococcus mutans（S. mutans）ATCC25175, porphyromonas gingivalis（P. gingivalis）ATCC33277.With table 5
In toothpaste be sample test matrix.Before carrying out antimicrobial preservation challenge test, the bacterium of determination sample, mould bacterial content, it is ensured that
Its numerical value is less than 10 cfu/g.
Table 5：Formulation of tooth-paste
Method of testing：Take the g of toothpaste 20 and be divided into four groups for totally 8 parts, the above two that 200 μ L are separately added into per group of 2 parts of samples is thin
The bacteria suspension of bacterium, makes to be reached 1.0 × 105 ~ 1.0 × 106 cfu/g by the final bacteria containing amount of sample product, fully mixes, filling
In flexible pipe, sealing.The sample of bacteria suspension will be vaccinated with to preserve under the conditions of 25 DEG C, the 0th, 7,14,21 and 28 after bacterium is connect
D sample analysis, calculate the bacteria containing amount in sample, to judge its antiseptic power by agar plate method.
Table 6：Results of preservation challenge tests in toothpaste
Remarks："+" indicates that a large amount of bacterium colonies occur in table.First group：Not adding preservative agent；Second group：The nipalgin for plus 0.05%
Propyl ester；3rd group：The plant-based bacteriostat for plus 1.0%；4th group：The plant source suppression of the propylben+0.5% for plus 0.05%
Microbial inoculum.
Result judgement standard：In 7 d, bacterial population declines and present in 99.9%, and 28 d continuous downward trend, then regard
It is excellent for antiseptic effect.Experimental result is shown in Table 6.As shown in Table 6, first group of non-adding preservative agent, without fungistatic effect；The
2nd, three, four groups have all passed through preservation challenge test.Second group adds propylben, and 7 days interior energies exist two kinds of bacteria concentrations
The microorganism of 105-106cfu/g is reduced to 210,180 cfu/g；3rd group has added plant-based bacteriostat, the effect of antibacterial
It is suitable with second group, microorganism is reduced into 270,120 cfu/g, it can be seen that the plant-based bacteriostat of the present invention is certain
Antisepsis can be played；4th group because add propylben and plant-based bacteriostat, respectively reduces microorganism in 7 days
To 230,110 cfu/g.
From the foregoing, it will be observed that the plant-based bacteriostat of the present invention has good antiseptic effect, but in view of plant-based bacteriostat
Antimicrobial spectrum is not very wide, preferably with other preservatives while using when using.The plant-based bacteriostat of the present invention and chemical synthesis
Preservative compounding use, can reduce the consumption of chemical synthesis preservative, so as to reduce the excitant of product, improve the peace of product
Quan Xing.
Above-described embodiment is the present invention preferably implementation, and in addition, the present invention can be realized with alternate manner,
Any obvious replacement is within protection scope of the present invention on the premise of without departing from present inventive concept.
Claims (8)
1. a kind of plant-based bacteriostat, it is characterised in that：Chinese medical extract comprising following percentage by weight：
Pomegranate rind extract 30%～90%
Chinese rhubarb extract 5%～30%
Shrubby sophora extract 5%～20%
Radix paeoniae alba extraction 1%～10%
Olive leaf P.E 1%～10%
Propolis extract 0.01%～5%
Wherein, the mass percent sum of above-mentioned raw materials is 100%.
2. a kind of plant-based bacteriostat according to claim 1, it is characterised in that：The pomegranate rind extract, rheum officinale are carried
Take thing, shrubby sophora extract, radix paeoniae alba extraction, Olive leaf P.E, propolis extract to obtain using organic solvent extraction：Will
After Chinese medicine material is crushed, 2.5-3.5h is extracted with the alcohol reflux of mass concentration 20-70%, it is after filtration that residue is dense with quality again
The alcohol reflux of degree 20-70% extracts 1.5-2.5h, filters, merging filtrate, by concentrating filter liquor after, with macroporous resin adsorption, use
The ethanol elution of mass concentration 30-70%, collects eluent, and reduced pressure concentration is obtained extract.
3. a kind of plant-based bacteriostat according to claim 2, it is characterised in that：Each solvent during the solvent extraction
Addition is 8-10 times of traditional Chinese medicine extraction raw material gross weight.
4. a kind of plant-based bacteriostat according to claim 2, it is characterised in that：The model of the macroreticular resin
D101。
5. a kind of plant-based bacteriostat according to claim 2, it is characterised in that：The pomegranate rind extract is dense with quality
The ethanol elution of degree 50-60%；The Chinese rhubarb extract ethanol elution of 60-70%；The shrubby sophora extract ethanol elution of 50-60%；
The radix paeoniae alba extraction ethanol elution of 40-50%；The Olive leaf P.E ethanol elution of 30-40%；Propolis extract 50-
60% ethanol elution.
6. a kind of plant-based bacteriostat according to claim 2, it is characterised in that：The plant source being concentrated under reduced pressure to give
Bacteriostatic agent quality is 0.5-5 times of Chinese medicine material.
7. a kind of hand cleanser of the plant-based bacteriostat containing described in any one of claim 1-6, it is characterised in that：By following matter
The raw material composition of amount percentage：
Sodium sulfate of polyethenoxy ether of fatty alcohol emulsion 11.6%
Cocoanut fatty acid diethanolamide 2.0%
Glycerine 2.5%
Glycine betaine 3.0%
Bay both sexes sodium acetate 2.0%
Disodium ethylene diamine tetraacetate 0.1%
Citric acid 0.12%
Sodium chloride 0.5%
Deionized water surplus,
Wherein, the mass concentration of the sodium sulfate of polyethenoxy ether of fatty alcohol emulsion is 70%, and the mass concentration of the glycine betaine is
35%。
8. a kind of toothpaste of the plant-based bacteriostat containing described in any one of claim 1-6, it is characterised in that：By following quality
The raw material composition of percentage：
Saccharin sodium 0.1%
Xylitol 0.2%
Lauryl sodium sulfate 1.2%
Sodium lauroyl sarcosine 0.5%
Glycerine 18.0%
Sorbierite 10.0%
Xanthans 0.75%
Sanlose 0.45%
Calcium monohydrogen phosphate 50%
Sodium pyrophosphate 0.5%
Deionized water surplus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611012651.8A CN106619438B (en) | 2016-11-17 | 2016-11-17 | Plant source bacteriostatic agent and hand sanitizer and toothpaste containing plant source bacteriostatic agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611012651.8A CN106619438B (en) | 2016-11-17 | 2016-11-17 | Plant source bacteriostatic agent and hand sanitizer and toothpaste containing plant source bacteriostatic agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106619438A true CN106619438A (en) | 2017-05-10 |
| CN106619438B CN106619438B (en) | 2020-04-21 |
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| CN201611012651.8A Active CN106619438B (en) | 2016-11-17 | 2016-11-17 | Plant source bacteriostatic agent and hand sanitizer and toothpaste containing plant source bacteriostatic agent |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107260605A (en) * | 2017-06-23 | 2017-10-20 | 合肥市风达农业有限责任公司 | A kind of disinfecting and decontaminating Traditional Chinese medicinal hand lotion and preparation method thereof |
| CN107811956A (en) * | 2017-11-30 | 2018-03-20 | 安徽省丰康农业科技有限公司蚌埠农业科技研发中心 | A kind of honey bacteriostatic agent and preparation method thereof |
| WO2019146669A1 (en) * | 2018-01-26 | 2019-08-01 | 株式会社山田養蜂場本社 | mTOR INHIBITOR |
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| CN103432047A (en) * | 2013-09-12 | 2013-12-11 | 广东轻工职业技术学院 | Natural preservative composition and application thereof in cosmetics |
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| CN105106099A (en) * | 2015-10-14 | 2015-12-02 | 吴颖斯 | Acne-removing bamboo charcoal mask containing plant compound preservative |
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| CN103432047A (en) * | 2013-09-12 | 2013-12-11 | 广东轻工职业技术学院 | Natural preservative composition and application thereof in cosmetics |
| CN104055685A (en) * | 2014-06-22 | 2014-09-24 | 广州悠美生物科技有限责任公司 | Bioactive micro-molecule polypeptide keratin essence |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107260605A (en) * | 2017-06-23 | 2017-10-20 | 合肥市风达农业有限责任公司 | A kind of disinfecting and decontaminating Traditional Chinese medicinal hand lotion and preparation method thereof |
| CN107811956A (en) * | 2017-11-30 | 2018-03-20 | 安徽省丰康农业科技有限公司蚌埠农业科技研发中心 | A kind of honey bacteriostatic agent and preparation method thereof |
| WO2019146669A1 (en) * | 2018-01-26 | 2019-08-01 | 株式会社山田養蜂場本社 | mTOR INHIBITOR |
| JPWO2019146669A1 (en) * | 2018-01-26 | 2021-01-28 | 株式会社山田養蜂場本社 | mTOR inhibitor |
| JP7256542B2 (en) | 2018-01-26 | 2023-04-12 | 株式会社山田養蜂場本社 | mTOR inhibitor |
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| CN106619438B (en) | 2020-04-21 |
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Denomination of invention: Plant-derived antibacterial agent and liquid soap and toothpaste with plant-derived antibacterial agent Effective date of registration: 20200727 Granted publication date: 20200421 Pledgee: China Co. truction Bank Corp Dongguan branch Pledgor: DONGGUAN BOTON FLAVORS & FRAGRANCES Co.,Ltd. Registration number: Y2020980004381 |
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Date of cancellation: 20220526 Granted publication date: 20200421 Pledgee: China Co. truction Bank Corp Dongguan branch Pledgor: DONGGUAN BOTON FLAVORS & FRAGRANCES Co.,Ltd. Registration number: Y2020980004381 |
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Address after: No. 8, Xixi Road, Liaobu Town, Dongguan City, Guangdong Province, 523000 Patentee after: Botton Spices Co.,Ltd. Address before: 523401 First Floor, Wealth Building, Liaobu Town, Dongguan City, Guangdong Province Patentee before: DONGGUAN BOTON FLAVORS & FRAGRANCES Co.,Ltd. |