CN106617044A - Food, healthcare product or medicine composition with effects of eliminating phlegm, quitting smoking and protecting respiratory tracts, method for preparing food, healthcare product or medicine composition and application thereof - Google Patents
Food, healthcare product or medicine composition with effects of eliminating phlegm, quitting smoking and protecting respiratory tracts, method for preparing food, healthcare product or medicine composition and application thereof Download PDFInfo
- Publication number
- CN106617044A CN106617044A CN201610841676.2A CN201610841676A CN106617044A CN 106617044 A CN106617044 A CN 106617044A CN 201610841676 A CN201610841676 A CN 201610841676A CN 106617044 A CN106617044 A CN 106617044A
- Authority
- CN
- China
- Prior art keywords
- parts
- food
- preparation
- crude drug
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 45
- 239000000203 mixture Substances 0.000 title claims abstract description 41
- 235000013305 food Nutrition 0.000 title claims abstract description 34
- 206010062717 Increased upper airway secretion Diseases 0.000 title claims abstract description 12
- 208000026435 phlegm Diseases 0.000 title claims abstract description 12
- 210000002345 respiratory system Anatomy 0.000 title claims abstract description 12
- 238000000034 method Methods 0.000 title claims abstract description 8
- 230000000391 smoking effect Effects 0.000 title abstract description 10
- 230000000694 effects Effects 0.000 title abstract description 8
- 229940079593 drug Drugs 0.000 claims abstract description 24
- 238000002360 preparation method Methods 0.000 claims abstract description 24
- 210000000582 semen Anatomy 0.000 claims abstract description 20
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 16
- 230000036541 health Effects 0.000 claims description 17
- 239000000843 powder Substances 0.000 claims description 16
- 239000009609 fructus phyllanthi Substances 0.000 claims description 13
- 230000005586 smoking cessation Effects 0.000 claims description 12
- 239000002671 adjuvant Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 230000001681 protective effect Effects 0.000 claims description 7
- 230000000295 complement effect Effects 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 238000000638 solvent extraction Methods 0.000 claims description 2
- 230000000968 intestinal effect Effects 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 239000000284 extract Substances 0.000 description 18
- 239000000047 product Substances 0.000 description 15
- 210000004072 lung Anatomy 0.000 description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 8
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 8
- 235000013402 health food Nutrition 0.000 description 7
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 5
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 5
- 239000000706 filtrate Substances 0.000 description 5
- 239000012467 final product Substances 0.000 description 5
- 238000003304 gavage Methods 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 4
- 206010036790 Productive cough Diseases 0.000 description 4
- 230000002354 daily effect Effects 0.000 description 4
- 239000013618 particulate matter Substances 0.000 description 4
- 210000003802 sputum Anatomy 0.000 description 4
- 208000024794 sputum Diseases 0.000 description 4
- 238000003915 air pollution Methods 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000029142 excretion Effects 0.000 description 3
- 230000002757 inflammatory effect Effects 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 239000013558 reference substance Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 210000003437 trachea Anatomy 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- 238000012449 Kunming mouse Methods 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 2
- 239000000809 air pollutant Substances 0.000 description 2
- 231100001243 air pollutant Toxicity 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 239000013010 irrigating solution Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 241000416162 Astragalus gummifer Species 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 238000008157 ELISA kit Methods 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 229910052793 cadmium Inorganic materials 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000001886 ciliary effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 231100000734 genotoxic potential Toxicity 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M sodium bicarbonate Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000759 toxicological effect Toxicity 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention provides a food, healthcare product or medicine composition with effects of eliminating phlegm, quitting smoking and protecting respiratory tracts. The food, healthcare product or medicine composition is a preparation prepared from, by weight, 1-40 parts of semen armeniacae amarum, 1-40 parts of pericarpium citri reticulatae, 1-30 parts of fructus gardeniae and 1-60 parts of poria. The invention further provides a method for preparing the food, healthcare product or medicine composition and application thereof. The food, healthcare product or medicine composition, the method and the application have the advantages that the food, healthcare product or medicine composition is safe and effective, and the excellent effects of eliminating the phlegm and quitting smoking and the excellent effect of protecting the respiratory tracts can be realized; the method is simple, food, healthcare food or medicines can be prepared from the food, healthcare product or medicine composition, and accordingly the food, healthcare product or medicine composition and the method have high practical application value.
Description
Technical field
The present invention relates to a kind of with eliminating the phlegm, the food of smoking cessation and respiratory tract protective effect, health product or drug regimen
Thing and its production and use.
Background technology
Epidemiological study both at home and abroad shows：Including including smoking particulate in air pollution with mankind's subhealthy status,
Morbidity, development or even the lethal presence of numerous disease is directly contacted.Particulate matter is entered after respiratory tract, except small part can be by breathing
Road ciliary movement is excreted or into outside digestive system in the form of sputum, most of long-term retention in lung tissue, and by
Gradually form focus.Some possess the element of genotoxic potential, and such as lead, cadmium, nickel, manganese, vanadium, bromine, zinc, benzopyrene polycyclic aromatic hydrocarbon can be inhaled
Invest on particulate matter, the toxicological effect mechanism for producing particulate matter is extremely complex, the theory of system is not yet formed at present illustrating
The infringement mechanism of particulate matter.In addition to the coup injury to respiratory system, a large amount of Clinical and experimental studies show, part subparticle
Thing can be diffused into whole body by the capillary network enriched in alveolar wall, and then have influence on cardiovascular system, blood system, or even
Immune system, reproductive system.
It is believed that impact of the particulate in air pollution to health is a progressive accelerator, such as not in time
Intervene, Susceptible population can gradually be presented corresponding subhealthy status, and to disease conversion.
The content of the invention
The technical scheme is that there is provided a kind of food, health care with eliminating the phlegm, smoking cessation and respiratory tract protective effect
Product or pharmaceutical composition.The present composition is constituted using the Chinese medicine of integration of edible and medicinal herbs, and sputum can be promoted to discharge, and mitigates lung tissue
In level of inflammation, intervene smoking desire, with long-term Clinical practice experience, thus with safe and definite effect
Feature.
Food of the present invention, health product or pharmaceutical composition, it is by the preparation of the crude drug comprising following weight proportioning
Into preparation：Semen Armeniacae Amarum 1-40 parts, Pericarpium Citri Reticulatae 1-40 parts, Fructus Gardeniae 1-30 parts, Poria 1-60 parts.
Wherein, it is the preparation being prepared from by the crude drug comprising following weight proportioning：Semen Armeniacae Amarum 10-20 parts, Pericarpium Citri Reticulatae
10-20 parts, Fructus Gardeniae 5-10 parts, Poria 20-50 parts, it is preferable that it is prepared from by the crude drug comprising following weight proportioning
Preparation：15 parts of Semen Armeniacae Amarum, 15 parts of Pericarpium Citri Reticulatae, 10 parts of Fructus Gardeniae, 20 parts of Poria.
Wherein, it is also including the crude drug of following weight proportioning：Radix Platycodoniss 1-60 parts, Fructus Phyllanthi 1-40 parts, Radix Glycyrrhizae 1-20 parts.
Wherein, the weight proportion of the crude drug is as follows：Radix Platycodoniss 20-40 parts, Fructus Phyllanthi 5-30 parts, Radix Glycyrrhizae 5-10 parts；It is excellent
Selection of land, the weight proportion of the crude drug is as follows：20 parts of Radix Platycodoniss, 15 parts of Fructus Phyllanthi, 5 parts of Radix Glycyrrhizae.
Wherein, the Semen Armeniacae Amarum is Semen Armeniacae Amarum (parched).
It is described it be aforementioned base materials protogenic medicinal powder or water or extractive with organic solvent, add field of food, health product
The preparation that field or pharmaceutically acceptable adjuvant or complementary composition are prepared from.
Wherein, the preparation is oral formulations or enteral nutrition agent.The preparation be decoction, powder, granule, tablet,
Suspensoid or capsule.
Present invention also offers a kind of method for preparing foregoing, it is comprised the steps of：
(1) crude drug is weighed；
(2) crude drug directly beats powder, or crude drug is added water to cook or organic solvent extraction, extracting solution concentration, adds
Field of food, field of health care products or pharmaceutically acceptable adjuvant or complementary composition are prepared into preparation.
Present invention also offers foregoing is preparing eliminating the phlegm, antiinflammatory, smoking cessation and/or with respiratory tract protective effect
Purposes in food, health product or medicine.
Compositionss of the present invention with eliminating the phlegm, smoking cessation and respiratory tract protective effect, are that inventor ties in abundant theoretical background
Formed in the case of closing long-term clinical application experience.Said composition is made up of 4-7 kind integration of edible and medicinal herbs Chinese medicines, with Radix Platycodoniss as monarch
Medicine, Semen Armeniacae Amarum (parched) and Poria are ministerial drug, and Pericarpium Citri Reticulatae and Fructus Gardeniae, Fructus Phyllanthi are adjuvant drug, and Radix Glycyrrhizae is to make medicine, effect experiment show that it can add
Fast mouse bronchial secreting rate, reduces pneumonia, mitigates volunteer's smoking desire.
Present composition safety, effectively, eliminating the phlegm, function of smoking cessation are excellent, with good respiratory tract protective effect, prepare
Method is simple, can be prepared as food, health food or medicine, is actually used there is provided a kind of new selection.
Obviously, the above of the invention, according to the ordinary technical knowledge and customary means of this area, without departing from
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification of other various ways can also be made, is replaced or is changed.
By the following examples the specific embodiment of form, remakes further specifically to the above of the present invention
It is bright.But this scope for being interpreted as above-mentioned theme of the invention should not be only limitted to Examples below.It is all based on the above of the present invention
The technology realized belongs to the scope of the present invention.
Specific embodiment
The preparation of the present composition of embodiment 1
Radix Platycodoniss 20g, Semen Armeniacae Amarum (parched) 15g, Pericarpium Citri Reticulatae 15g, Fructus Gardeniae 10g, Poria 20g, Fructus Phyllanthi 15g, Radix Glycyrrhizae 5g are taken, is returned with water
Stream is extracted 2 times, and first time adds 12 times of volumes, second plus 10 times of volumes to flow back 2 hours every time, filter, merging filtrate,
Relative density about 1.25g/ml is concentrated into, plus ethanol makes alcohol content up to about 80%v/v, stands and solid-liquid separation, takes supernatant, returns
Ethanol is received, concentrated, be dried, it is extract obtained to crush 60 mesh sieves, obtain final product extract powder 21kg of the present invention.
Extract powder of the present invention is taken, field of food, field of health care products or pharmaceutically acceptable adjuvant or auxiliary is added
Helping property composition, is obtained food of the present invention, health food or medicine.
The preparation of the present composition of embodiment 2
Radix Platycodoniss 40g, Semen Armeniacae Amarum (parched) 10g, Pericarpium Citri Reticulatae 10g, Fructus Gardeniae 8g, Poria 30g, Fructus Phyllanthi 5g, Radix Glycyrrhizae 10g are taken, is returned with water
Stream is extracted 2 times, and first time adds 10 times of volumes, second plus 8 times of volumes to flow back 2 hours every time, filter, and merging filtrate is dense
Contracting drying, it is extract obtained to crush 60 mesh sieves, obtain final product extract powder of the present invention.
Extract powder of the present invention is taken, field of food, field of health care products or pharmaceutically acceptable adjuvant or auxiliary is added
Helping property composition, is obtained food of the present invention, health food or medicine.
The preparation of the present composition of embodiment 3
Radix Platycodoniss 30g, Semen Armeniacae Amarum (parched) 20g, Pericarpium Citri Reticulatae 20g, Fructus Gardeniae 5g, Poria 50g, Fructus Phyllanthi 30g, Radix Glycyrrhizae 8g are taken, plus 60%
Alcohol reflux 3 times, first time adds 8 times of volumes, second and third time to add 6 times of volumes respectively, backflow 1～2 every time
Hour, filtration, merging filtrate reclaims ethanol, concentration, is dried, extract obtained crushing, obtain final product extract powder of the present invention.
Extract powder of the present invention is taken, field of food, field of health care products or pharmaceutically acceptable adjuvant or auxiliary is added
Helping property composition, is obtained food of the present invention, health food or medicine.
The preparation of the present composition of embodiment 4
Radix Platycodoniss 1g, Semen Armeniacae Amarum (parched) 40g, Pericarpium Citri Reticulatae 1g, Fructus Gardeniae 30g, Poria 1g, Fructus Phyllanthi 40g, Radix Glycyrrhizae 1g are taken, is flowed back with water
Extract 2 times, 10 times of volumes are added for the first time, 8 times of volumes are added for the second time, every time backflow 2 hours, filter, merging filtrate, concentrate
It is dried, it is extract obtained to crush 60 mesh sieves, obtain final product extract powder of the present invention.
Extract powder of the present invention is taken, field of food, field of health care products or pharmaceutically acceptable adjuvant or auxiliary is added
Helping property composition, is obtained food of the present invention, health food or medicine.
The preparation of the present composition of embodiment 5
Radix Platycodoniss 60g, Semen Armeniacae Amarum (parched) 1g, Pericarpium Citri Reticulatae 40g, Fructus Gardeniae 1g, Poria 30g, Fructus Phyllanthi 1g, Radix Glycyrrhizae 20g are taken, is flowed back with water
Extract 2 times, 10 times of volumes are added for the first time, 8 times of volumes are added for the second time, every time backflow 2 hours, filter, merging filtrate, concentrate
It is dried, it is extract obtained to crush 60 mesh sieves, obtain final product extract powder of the present invention.
Extract powder of the present invention is taken, field of food, field of health care products or pharmaceutically acceptable adjuvant or auxiliary is added
Helping property composition, is obtained food of the present invention, health food or medicine.
Beneficial effects of the present invention are proved below by way of experimental example.
Impact of the present composition of experimental example 1 to the phenol red excretion of mice
KM mices 50, are divided into 5 groups, respectively model control group (0.5% tragacanth) by body weight stratified random, sun
Property matched group (ammonium chloride), the full side's group (formula of embodiment 1) of compositionss.
Gavage is given by test product or reference substance, and continuous 3 days, dosage was 0.2ml/10g.Hungry 16～18 is little before experiment
When, only for drinking-water.Last dose is being injected phenol red front 30min gavages, the then phenol red life of lumbar injection 1% by test product or reference substance
Reason saline solution 0.2ml/10g, the de- necks of 30min are put to death after injection.Slightly waiting makes blood coagulation in mice body, to cut off cervical region
Skin separates trachea, tracheal intubation and is connected with syringe without obvious bleeding (in order to avoid phenol red in blood be mixed into irrigating solution), uses
5%NaHCO30.8ml, is slowly injected into tracheal strips, then gently suctions out, so repeatedly 5 times, irrigating solution place certain hour make it is miscellaneous
Matter is precipitated, and the transparent red supernatant for obtaining, with spectrophotometer wavelength 545nm colorimetrics, is calculated according to phenol red standard curve
Phenol red amount.
Impact of the compositionss group of table 1 to the phenol red excretion of mice
Compare with model control group, * P ＜ 0.05, * * P ＜ 0.01
As a result it is as shown in table 1.Present composition extract gives 3 in 0.4g/kg dosage gavages, can dramatically increase little
The phenol red excretion of Mus trachea, illustrates that it can promote sputum to secrete.
Experimental result illustrates that pharmaceutical composition of the present invention can effectively facilitate sputum secretion, there is eliminating the phlegm.
The present composition of experimental example 2 damages the impact of inflammatory factor in mouse lung tissue to experimental lung
SPF level Kunming mouses, male and female half and half are divided into 10 groups by body weight stratified random, 10 per group, respectively sham-operation
Matched group, model control group, positive controls (Bulbus Fritillariae Cirrhosae), the full side's group (formula of embodiment 1) of compositionss, the compositionss side of tearing open group
(2 groups of the side of tearing open) (Semen Armeniacae Amarum (parched)/Pericarpium Citri Reticulatae/Fructus Gardeniae/Poria), the compositionss side of tearing open group (1 group of the side of tearing open) (Radix Platycodoniss/Fructus Phyllanthi/Radix Glycyrrhizae), stir-fry
Semen Armeniacae Amarum group, Pericarpium Citri Reticulatae group, Fructus Gardeniae group, Poria group.The side of tearing open organizes the mutual ratio of each composition and preparation method is identical with full side's group.
Each group circulation of qi promoting pipe separating operation, in addition to Sham-operated control group, gives air pollutants suspension in trachea
0.1ml, subsequently suture.Postoperative 2 days, respectively gavage give by test product or reference substance, one time a day, continuous 7d.After last gives
1h, puts to death animal, takes lung homogenate standby.TNF-α concentration in lung tissue is determined with mouse ELISA kit.As a result such as the institute of table 2
Show.
Table 2 damages the impact of inflammatory factor in mouse lung tissue and blood to experimental lung
| Group | Dosage (g/kg) | TNF-α(pg/ml) |
| Sham-operation is compareed | —— | 2.7±0.3** |
| Model comparison | — | 40.5±6.9 |
| Positive control (Bulbus Fritillariae Cirrhosae) | 0.4g/kg | 25.1±6.3** |
| Compositionss (embodiment 1) | 0.4g/kg | 28.3±4.7** |
| The compositionss side of tearing open (2 groups of the side of tearing open) | 0.4g/kg | 32.4±7.3* |
| Semen Armeniacae Amarum (parched) | 0.4g/kg | 37.2±7.1# |
| Pericarpium Citri Reticulatae | 0.4g/kg | 38.5±8.2# |
| Fructus Gardeniae | 0.4g/kg | 39.8±6.6## |
| Poria | 0.4g/kg | 40.9±5.8## |
| The compositionss side of tearing open (1 group of the side of tearing open) | 0.4g/kg | 35.2±5.1*# |
Compare with model group：*P<0.05,**P<0.01；Compared with the full side's group of compositionss, # ＜ 0.05,##P<0.01
As a result show, mice transtracheal is given after air pollutants suspension, may occur in which obvious pneumonia, main inflammatory
Factor TNF-α content significantly rises.Gavage gives the present composition and the side's of tearing open prescription (2 groups of the side of tearing open), can significantly reduce lung
TNF-α content in tissue.Compare with remaining 4 kinds of medicines exclusive use for 1 group with the side of tearing open, the effect is significant of the present composition is improved
(p<0.05)。
Experimental result illustrates that pharmaceutical composition of the present invention can reduce TNF-α content in lung tissue, the work with antiinflammatory
With, the pulmonary lesion caused because of air pollution can be protected, and act on excellent.
Smoking cessation of the present composition of experimental example 3 to smoker is acted on
Collection 20 daily boxes of smoking 1 (20) more than adult male, the age between 19-60 year, by daily smoking
Amount and age are divided at random 2 groups, and 1 group is treatment group, and 2 groups is matched group.Treatment group patient is edible daily of the invention preferred
The teabag (3g/ bags) of prescription composition of proportions, 3 times a day, 1 bag every time.Continuously drink 4 weeks, and rank is calculated the 2nd week, 4 weekends
Daily smoking capacity in section.As a result such as table 3.
The present composition of table 3 is acted on the smoking cessation to smoker
Note：Compare with matched group：* P ＜ 0.05；* P ＜ 0.01
As a result point out, adhere to drinking the teabag of present composition composition, Nicotiana tabacum L. captivation can be significantly reduced, reduce every
Day smoking capacity, it was demonstrated that the present composition is acted on smoking cessation.
Experimental result illustrates that pharmaceutical composition of the present invention has functions that smoking cessation.
To sum up, present composition safety, effectively, eliminating the phlegm, lung preversation and smoking cessation assosting effect are excellent, preparation method letter
It is single, food, health food or medicine are can be prepared as, with preferable market application foreground.
Claims (10)
1. a kind of food, health product or pharmaceutical composition, is characterized in that：It is by the crude drug system comprising following weight proportioning
Standby preparation：Semen Armeniacae Amarum 1-40 parts, Pericarpium Citri Reticulatae 1-40 parts, Fructus Gardeniae 1-30 parts, Poria 1-60 parts.
2. compositionss according to claim 1, is characterized in that：It is by the preparation of the crude drug comprising following weight proportioning
Into preparation：Semen Armeniacae Amarum 10-20 parts, Pericarpium Citri Reticulatae 10-20 parts, Fructus Gardeniae 5-10 parts, Poria 20-50 parts, it is preferable that it is by including down
State the preparation that the crude drug of weight proportion is prepared from：15 parts of Semen Armeniacae Amarum, 15 parts of Pericarpium Citri Reticulatae, 10 parts of Fructus Gardeniae, 20 parts of Poria.
3. compositionss according to claim 1 and 2, is characterized in that：It is also including the crude drug of following weight proportioning：Radix Platycodoniss
1-60 parts, Fructus Phyllanthi 1-40 parts, Radix Glycyrrhizae 1-20 parts.
4. compositionss according to claim 3, is characterized in that：The weight proportion of the crude drug is as follows：Radix Platycodoniss 20-40
Part, Fructus Phyllanthi 5-30 parts, Radix Glycyrrhizae 5-10 parts；Preferably, the weight proportion of the crude drug is as follows：20 parts of Radix Platycodoniss, Fructus Phyllanthi 15
Part, 5 parts of Radix Glycyrrhizae.
5. compositionss according to claim 1-4 any one, it is characterised in that：The Semen Armeniacae Amarum is Semen Armeniacae Amarum (parched).
6. compositionss according to claim 1-5 any one, it is characterised in that：It is the protogenic medicinal powder of aforementioned base materials or
Person's water or extractive with organic solvent, add field of food, field of health care products or pharmaceutically acceptable adjuvant or it is complementary into
Divide the preparation being prepared from.
7. compositionss according to claim 1-6 any one, it is characterised in that：The preparation is oral formulations or intestinal
Nutrient.
8. pharmaceutical composition according to claim 7, it is characterised in that：The preparation is decoction, powder, granule, piece
Agent, suspensoid or capsule.
9. a kind of method for preparing compositionss described in claim 1-8 any one, it is characterised in that：It is comprised the steps of：
(1) crude drug is weighed；
(2) crude drug directly beats powder, or crude drug is added water to cook or organic solvent extraction, extracting solution concentration, adds food
Field, field of health care products or pharmaceutically acceptable adjuvant or complementary composition are prepared into preparation.
10. claim 1-8 any one compositionss are preparing eliminating the phlegm, antiinflammatory, smoking cessation and/or with respiratory tract protective effect
Purposes in food, health product or medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610841676.2A CN106617044B (en) | 2016-09-22 | 2016-09-22 | Food, health product or pharmaceutical composition with phlegm eliminating, smoking stopping and respiratory tract protecting effects, and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610841676.2A CN106617044B (en) | 2016-09-22 | 2016-09-22 | Food, health product or pharmaceutical composition with phlegm eliminating, smoking stopping and respiratory tract protecting effects, and its preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106617044A true CN106617044A (en) | 2017-05-10 |
| CN106617044B CN106617044B (en) | 2020-10-02 |
Family
ID=58852208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610841676.2A Active CN106617044B (en) | 2016-09-22 | 2016-09-22 | Food, health product or pharmaceutical composition with phlegm eliminating, smoking stopping and respiratory tract protecting effects, and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106617044B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810714A (en) * | 2010-05-20 | 2010-08-25 | 沈阳神龙药业有限公司 | Sugar-free almond perilla anti-cough granules and preparation method thereof |
| CN102552487A (en) * | 2012-02-14 | 2012-07-11 | 刘克成 | Chinese medicinal composition for relieving swelling and sore throat and throat foreign body sensation, and preparation method and application thereof |
| CN103251845A (en) * | 2013-06-04 | 2013-08-21 | 广州安健实业发展有限公司 | Composition for clearing heat from throat and wetting throat |
| CN104189562A (en) * | 2014-08-09 | 2014-12-10 | 河南中医学院 | Sugarcane, folium mori and platycodon grandiflorum granules for treating cough post influenza |
| CN105362407A (en) * | 2015-12-16 | 2016-03-02 | 成都市康飞药业有限公司 | Composition for preventing and/or treating sub-health caused by smoking |
-
2016
- 2016-09-22 CN CN201610841676.2A patent/CN106617044B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810714A (en) * | 2010-05-20 | 2010-08-25 | 沈阳神龙药业有限公司 | Sugar-free almond perilla anti-cough granules and preparation method thereof |
| CN102552487A (en) * | 2012-02-14 | 2012-07-11 | 刘克成 | Chinese medicinal composition for relieving swelling and sore throat and throat foreign body sensation, and preparation method and application thereof |
| CN103251845A (en) * | 2013-06-04 | 2013-08-21 | 广州安健实业发展有限公司 | Composition for clearing heat from throat and wetting throat |
| CN104189562A (en) * | 2014-08-09 | 2014-12-10 | 河南中医学院 | Sugarcane, folium mori and platycodon grandiflorum granules for treating cough post influenza |
| CN105362407A (en) * | 2015-12-16 | 2016-03-02 | 成都市康飞药业有限公司 | Composition for preventing and/or treating sub-health caused by smoking |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106617044B (en) | 2020-10-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103007053B (en) | Dendrobium officinale compound preparation as well as preparation method and application thereof | |
| CN106237075B (en) | Food, health-care product or pharmaceutical composition with anti-fatigue and attention-improving functions as well as preparation method and application thereof | |
| CN102302091B (en) | Chinese herb medicine feed additive used for treating low sexual function of male breeding poultry and preparation method thereof | |
| CN104208163B (en) | It is a kind of improve animal immunizing power Chinese veterinary medicinal composition, using and preparation method thereof | |
| CN103191298B (en) | Traditional Chinese medicinal composition for treating blood group incompatibility haemolytic disease and preparation method thereof | |
| CN101190306B (en) | Compound composition with qi-complementing and spleen-invigorating function and preparation method and application thereof | |
| CN105456818A (en) | Traditional Chinese medicine composition containing folium artemisiae argyi and being capable of treating insomnia and preparation method of traditional Chinese medicine composition | |
| CN106617044A (en) | Food, healthcare product or medicine composition with effects of eliminating phlegm, quitting smoking and protecting respiratory tracts, method for preparing food, healthcare product or medicine composition and application thereof | |
| CN101837046A (en) | Anti-virus Chinese medicinal preparation and preparation method thereof | |
| CN103977127B (en) | A kind of Chinese medicine composition for the treatment of infantile asthma and preparation method thereof | |
| CN101693086B (en) | Traditional Chinese medicine compound preparation for preventing recurrent aphthae, preparation method and application thereof | |
| CN103191399A (en) | Traditional Chinese medicine composition for treating bronchial asthma in acute-outbreak period | |
| CN102908489B (en) | Traditional Chinese medicine composition for treating seborrheic alopecia and preparation method of same | |
| CN103405722B (en) | Chinese herba preparation for preventing and treating infantile cough | |
| CN105362645A (en) | Preparation method of pharmaceutical composition for treating oral inflammations | |
| CN107158286B (en) | Traditional Chinese medicine composition for treating respiratory tract injury induced symptoms caused by haze and preparation method thereof | |
| CN102949681B (en) | Composition for preventing or treating colds, and its preparation method | |
| CN104435672A (en) | Pine-pollen-containing traditional Chinese medicine composition for enhancing immunity | |
| CN103585434B (en) | Traditional Chinese medicine composition for treating anemia | |
| CN104645005A (en) | Traditional Chinese medicine composition for treating menopausal somnipathy and preparation method thereof | |
| CN104225201A (en) | Medicinal composition for treating cough | |
| CN105168519B (en) | With the composition and its preparation method and application for improving sleep function | |
| CN107582834A (en) | A kind of Chinese medicine composition for treating empty asthma | |
| CN105311419A (en) | Traditional Chinese medicine composition for treating oral inflammations and preparation method thereof | |
| CN1403129A (en) | Chinese medicine prepn for stopping drug addiction |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |