CN106609237B - Reagent work station with platform structure - Google Patents
Reagent work station with platform structure Download PDFInfo
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- CN106609237B CN106609237B CN201510705215.8A CN201510705215A CN106609237B CN 106609237 B CN106609237 B CN 106609237B CN 201510705215 A CN201510705215 A CN 201510705215A CN 106609237 B CN106609237 B CN 106609237B
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- reagent
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- platform structure
- work station
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
- C12N15/1013—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by using magnetic beads
Abstract
The present invention relates to biological reagent processing equipment fields, provide a kind of reagent work station with platform structure；The reagent work station includes shell and function platform module, and the shell includes bottom plate, and an electric cabinet drawer is provided on the bottom plate, and the top of electric cabinet drawer is arranged in the function platform module；The platform structure is movably arranged on the shell, for limiting pull of the electric cabinet drawer on bottom plate；The platform structure includes the horizontal panel for placing article；The beneficial effects of the present invention are: being convenient to pull out electric cabinet drawer from bottom plate and being safeguarded and repaired, platform structure provides window for the maintenance and maintenance of electric cabinet drawer, simplifies the maintenance, repair mode of electric cabinet drawer.
Description
Technical field
The present invention relates to biological reagent processing equipment fields, it is more particularly related to which a kind of have platform structure
Reagent work station.
Background technique
Nucleic acid extraction technology is widely used in biology, field of medicaments, and the core of higher degree is obtained from biological sample
Acid is the premise accurately examined to nucleic acid, in particular for the biological sample that extracts in pollution environment, nucleic acid extraction
Accuracy is particularly important.
There is a kind of automatic nucleic acid to mention extraction element in the prior art, there are six functional areas for nucleic acid-extracting apparatus setting:
Sample area, consumptive material area, reagent area, transfer area, nucleic acid extraction area and waste area.Sample area is for placing experiment to sample
Product, consumptive material needed for consumptive material area is used to place experiment, reagent needed for reagent area is used to place experiment, magnetic is arranged in nucleic acid extraction area
Pearl isolates and purifies system and carries out nucleic acid extraction, and transfer area is provided with carrier and adds for placing the elements such as including deep-well plates for sample
Sample, reagent addition preparation etc. operate, and may include discarded suction nozzle collecting vessel, waste liquid tank in waste area.
In addition, nucleic acid-extracting apparatus is additionally provided with electric cabinet control system, each functional areas are controlled by electric cabinet control system
Running, such as by the Beads enrichment purification system in electric cabinet control system control nucleic acid extraction area, realize Beads enrichment.But it is existing
Electric cabinet control system be generally located in the pedestal or rear wall of nucleic acid-extracting apparatus, when repairing or safeguarding to electric cabinet,
It can be repaired after needing the disassembling shell by nucleic acid-extracting apparatus or maintenance, after repairing or safeguarding, and needing will be outer
Shell is installed, and the process of disassembling shell and installation is very cumbersome, brings inconvenience to the maintenance and maintenance of electric cabinet.
Therefore a kind of reagent work station with platform structure convenient for repairing and safeguarding to electric cabinet is needed.
Summary of the invention
The purpose of the present invention is to provide a kind of reagent work station with platform structure, it is intended to solve prior art pilot scale
The electric cabinet of agent work station is not easy to the problem of repairing and safeguarding.
In order to realize goal of the invention, a kind of reagent work station with platform structure is theed improvement is that: the reagent
Work station includes shell and function platform module, and the shell includes bottom plate, and an electric cabinet drawer is provided on the bottom plate, described
The top of electric cabinet drawer is arranged in function platform module；
The platform structure is movably arranged on the shell, which is used to control the electric cabinet drawer bottom of at
Extraction or push-in are realized on plate；The platform structure includes the horizontal panel for placing article.
Wherein, the lower end of the platform structure and the bottom plate are rotatablely connected.
Wherein, the shell includes front panel, and protective door, the platform structure and protective door are provided on the front panel
Bottom end connection.
Further, the platform structure is fixed on the bottom end of protective door, the protective door and platform structure relative to
Front panel moves up and down.
Further, the platform structure is fixed on the bottom end of protective door, the protective door and platform structure relative to
Front panel side-to-side movement.
Further, the shell includes front panel and top plate, and front panel is connect with top panel turns, the platform structure
It is fixed on the bottom end of front panel, front panel drives platform structure to rotate relative to front panel.
Wherein, the platform structure is fixed on the one side of electric cabinet drawer.
Wherein, it is provided with anti-skid chequer on the horizontal panel or is provided with the groove for placing container.
Wherein, the function platform module includes pedestal, reagent storage unit, consumptive material unit, waste unit, reagent reaction
Unit and sample storage unit, the reagent storage unit, consumptive material unit, waste unit, reagent reaction member and sample storage
Unit is all made of drawer-type structure and is mounted on the base in the form of dismountable.
Further, multiple drawer limiting components, each adjacent drawer limiting component are provided in the function platform module
Between spacing be a, the reagent storage unit, consumptive material unit, waste unit, reagent reaction member and sample storage unit
Width be a integral multiple；The reagent storage unit, consumptive material unit, waste unit, reagent reaction member and sample storage
The drawer detent with the cooperation of drawer limiting component is provided on unit bottom surface.
Wherein, the reagent work station further includes liquid relief module and main control module, and the liquid relief module is located in shell
Top, for being pipetted according to the instruction of main control module realization to reagent.
Further, the pedestal is equipped with multiple interfaces connecting with main control module, the reagent storage unit, consumptive material
Unit, waste unit, reagent reaction member and sample storage unit rear portion are provided with the socket matched with the interface of pedestal.
Further, the reagent storage unit, consumptive material unit, waste unit, reagent reaction member and sample storage
Unit front end all has display device.
Further, the display device is for visualizingre agent storage unit, consumptive material unit, waste unit, reagent reaction
Unit, sample storage unit respectively with the connection status of pedestal.
Further, the display device is indicator light.
Further, the reagent work station further includes nucleic acid extraction module, and the nucleic acid extraction module is located in shell,
For realizing automatically extracting for nucleic acid, including gear unit and oscillating unit according to the instruction of main control module；The gear unit
For realizing the movement of carried container, the gear unit includes the kit flowing water for being used for transmission the container for holding reagent
Line；The oscillating unit is for being stirred the reagent in the container placed on gear unit.
Further, the kit assembly line includes conveyer belt, and the container is detachably mounted on conveyer belt.
Wherein, the more of different model are provided on the platform structure to lock equipment, equipment lock is for by platform knot
Structure is locked on the shell of reagent work station.
From the foregoing, it will be observed that setting of the present invention by platform structure, is convenient to that electric cabinet drawer is pulled out and carried out from bottom plate
Maintenance and maintenance, platform structure provide window for the maintenance and maintenance of electric cabinet drawer, simplify the maintenance, repair of electric cabinet drawer
Mode.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the reagent work station in an example of the present invention with platform structure.
Fig. 2 a, Fig. 2 b are the structural schematic diagrams of the reagent work station with platform structure in another example of the invention.
Fig. 3 a, Fig. 3 b, Fig. 3 c are the structural representations of the reagent work station with platform structure in another example of the invention
Figure.
Fig. 4 a, Fig. 4 b are the structural schematic diagrams of the reagent work station with platform structure in another example of the invention.
Fig. 5 is the structural schematic diagram of the reagent work station with platform structure in another example of the invention.
Fig. 6 a, Fig. 6 b are the structural schematic diagrams of the reagent work station with platform structure in another example of the invention.
Fig. 7 is the implementation example figure of function platform module in an example of the present invention.
Fig. 8 a, Fig. 8 b are the structural schematic diagram of drawer unit in function platform module of the present invention.
Fig. 9 a, Fig. 9 b are the drawer limiting component of drawer unit and two kinds of specific implementation example diagrams of drawer detent.
Figure 10 is the structural schematic diagram of interface on the socket and pedestal of drawer unit.
Figure 11 is the structural schematic diagram of the reagent work station with platform structure in another example of the invention.
Figure 12 is the implementation example figure of the kit assembly line of nucleic acid extraction module of the present invention.
Figure 13 a, Figure 13 b, Figure 13 c are the kit assembly line of nucleic acid extraction module and the structural schematic diagram of container.
Figure 14 is the structural schematic diagram of liquid relief module of the invention.
Figure 15 a, Figure 15 b are two kinds of specific implementation example diagrams of the horizontal panel of platform structure.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawings and embodiments, right
The present invention is further elaborated.
The present invention proposes an example, shown referring to Fig.1, and the reagent work station 10 with platform structure includes shell
101 and function platform module 20, the shell include bottom plate 103, an electric cabinet drawer 30 is provided on bottom plate 103, and described
Function platform module 20 top of electric cabinet drawer 30 is set.
The platform structure 40 is movably fixed on the shell 101, which is used to control the electricity
Cabinet drawer 30 realizes extraction or push-in on bottom plate 103；The platform structure 40 includes the horizontal panel for placing article
401。
In the present invention, since platform structure 40 is movably fixed on shell 101, platform structure 40 is relative to electric cabinet drawer
30 at least have two states, including closed state and open state, when platform structure 40 is in close state down, that is, scheme
When in the state of shown in 1, electric cabinet drawer 30 is limited on bottom plate 103 by platform structure 40, and the position of electric cabinet drawer 30 then cannot
It changes, can not be extracted out from bottom plate 103；When under platform structure 40 is in the open state, electric cabinet drawer 30 can be the bottom of from
It is extracted out on plate 103, therefore, the design of platform structure 40 is convenient to that electric cabinet drawer 30 is pulled out and safeguarded from bottom plate 103
And maintenance, platform structure 40 provide window for the maintenance and maintenance of electric cabinet drawer 30, simplify electric cabinet drawer 30 maintenance and
Maintenance mode.In addition, the platform structure 40 includes the horizontal panel 401 for placing article, which is provided
One interim platform for placing reagent, consumptive material, during being operated to function platform module 20, such as flat to function
During reagent is added manually in sample area in platform module 20, reagent can be temporarily placed on horizontal panel 401, when need
It is directly taken from horizontal panel 401 when continuing to use reagent, improves manually-operated efficiency.
For the connection type of platform structure 40 and shell 101, the present invention provides an examples, in this example, described
Reagent work station with platform structure 40 includes shell 101 and function platform module 20, and the shell 101 includes bottom plate 103,
An electric cabinet drawer 30 is provided on bottom plate 103, and the top of electric cabinet drawer 30 is arranged in the function platform module 20.Institute
The lower end and the bottom plate 103 for stating platform structure 40 are rotatablely connected, and platform structure 40 includes the horizontal plane for placing article
Plate 401.In this example, the platform structure 40 has closed state and open state, closes shape when platform structure 40 is in
When state, the horizontal panel 401 of platform structure 40 provides one for interim placement reagent, the platform of consumptive material.As shown in Figure 2 a,
For the structural schematic diagram in the open state of platform structure 40, platform structure 40 is around the rotating joint with the bottom plate 103
After rotation, electric cabinet drawer 30 can then be pulled out from bottom plate 103 at this time, as shown in Figure 2 b, reagent work station as of the invention
The structural schematic diagram that is pulled out from bottom plate 103 of electric cabinet drawer 30 then can be directly right when breaking down inside electric cabinet drawer 30
Electric cabinet drawer 30 repairs, and simplifies the maintenance mode of electric cabinet drawer 30.It, then can be straight after the completion of the maintenance of electric cabinet drawer 30
It connects and electric cabinet drawer 30 is pushed on bottom plate 103, then platform structure 40 is turned into original closed state.
It is as shown in Figure 3a, described to have the present invention also provides an example for the connection type of platform structure and shell
The reagent work station of platform structure 40 includes shell 101 and function platform module 20, and shell includes bottom plate 103, is set on bottom plate 103
It is equipped with an electric cabinet drawer 30, and the top of electric cabinet drawer 30 is arranged in the function platform module 20.The platform structure
40 include the horizontal panel 401 for placing article.In this example, the shell 101 includes front panel 104, front panel 104
It is inside provided with protective door 105, the platform structure 40 is connect with the bottom end of protective door 105.As shown in Figure 3a, the protective door
In 105 insertion front panels 104, protective door 105 can be made of transparent material, such as glass etc., can be convenient staff
To being observed inside reagent work station 10 in 10 course of work of reagent work station.In this example, the platform structure
40 have closed state and open state, are the closed mode schematic diagram of platform structure 40 shown in Fig. 3 a, at this time platform structure
40 are limited in electric cabinet drawer 30 on bottom plate 103, can prevent from touching electric cabinet drawer when electric cabinet drawer 30 is without failure
30, improve the security performance of electric cabinet drawer 30.It is the open state schematic diagram of platform structure, at this time platform knot shown in Fig. 3 b
Horizontal panel 401 on structure 40 is connected on the bottom end of protective door 105, and after protective door 105 moves upwards, platform structure 40 is then
It moves upwards together, forms state as shown in Figure 3b, at this point, electric cabinet drawer 30 can be pulled out from bottom plate 103, when electric cabinet is taken out
When breaking down inside drawer 30, then directly electric cabinet drawer 30 can be repaired, simplify the maintenance mode of electric cabinet drawer 30.
In addition, on the basis of the scheme shown in Fig. 3 a, Fig. 3 b, the invention also provides an example, the platform structure 40
It is connect with the bottom end of protective door 105, as shown in Figure 3c, when platform structure 40 is in off state, platform structure 40 takes out electric cabinet
Drawer 30 is limited on bottom plate 103, can prevent from touching electric cabinet drawer 30 when electric cabinet drawer 30 is without failure, improves electric cabinet
The security performance of drawer 30；When platform structure 40 is open state, platform structure 40 and protective door 105 can be relative to fronts
104 side-to-side movement of plate, when platform structure 40 moves to right end position shown in Fig. 3 c with protective door 405, electric cabinet drawer 40
It can pull out from bottom plate 103, when breaking down inside electric cabinet drawer 30, then directly electric cabinet drawer 30 can be repaired,
Simplify the maintenance mode of electric cabinet drawer 30.It should be noted that platform structure 40 is connected on the bottom end of protective door 105, and
When moving (up and down motion or side-to-side movement) together with protective door 105, the horizontal panel 401 of platform structure 40 is still in level
Position, therefore in the example described in Fig. 3 b and Fig. 3 c, when need to pull out electric cabinet drawer 30 from bottom plate 103 carry out maintenance or
When maintenance, reagent or consumptive material still can be placed on horizontal panel 401, avoid needing when repairing electric cabinet drawer 30 by reagent
Or consumptive material is removed from horizontal panel 401, saves the time of the maintenance of electric cabinet drawer 30 or maintenance.
As shown in fig. 4 a, for the connection type of platform structure 40 and shell 101, the invention also provides an example, institutes
Stating the reagent work station 10 with platform structure 40 includes shell 101 and function platform module 20, wherein the shell 101
Including bottom plate 103, top plate 106 and front panel 104, an electric cabinet drawer 30 is provided on bottom plate 103, function platform module 20 is set
It sets in the top of electric cabinet drawer 30.The platform structure 40 is movably arranged on shell 101, in this example, the platform knot
Structure 40 is fixedly connected with the bottom of front panel 104 and connect, and the front panel 104 and top plate 106 are rotatablely connected, platform knot
Structure 40 is with having closed state and open state, and as shown in fig. 4 a, the as closed state of platform structure 40, electric cabinet is taken out at this time
The side of drawer 30 leans against on the side of platform structure 40, and electric cabinet drawer 30 is limited on bottom plate 103 by platform structure 40, Wu Fazhi
It connects and pulls out electric cabinet drawer 30 from bottom plate 103, improve the security performance of electric cabinet drawer 30.As shown in Figure 4 b, as platform
The schematic diagram in the open state of structure 40, since front panel 104 and the top plate 106 are rotatablely connected, platform structure 40 is solid
It is scheduled on the bottom of front panel 104, therefore platform structure 40 can be as front panel 104 be together around front panel 104 and top plate 106
Rotating joint rotation, when platform structure 40 and front panel 104 turn to state as shown in Figure 4 b, as platform structure
40 open state, electric cabinet drawer 30 can be extracted out directly from bottom plate 103 at this time, break down inside electric cabinet drawer 30
When, then directly electric cabinet drawer 30 can be repaired, simplify the maintenance mode of electric cabinet drawer 30.In addition, due to platform structure
40 are fixed on the bottom of front panel 104, and front panel 104 and platform structure 40 rotate together, thus when platform structure 40 with
, can be fully open by the inside 10 of reagent work station when front panel 104 turns to state as shown in Figure 4 b, it is convenient to people
The function platform module 20 of reagent work station 10 is operated.
As shown in figure 5, the invention also provides an example, reagent work stations for platform structure 40 and electric cabinet drawer 30
10 include shell 101, function platform module 20 and main control module, and the main control module is integrated in electric cabinet drawer 30, described
The elements such as pcb board, driver, Switching Power Supply are provided in electric cabinet drawer 30.The shell includes bottom plate 103 and front panel 104,
An electric cabinet drawer 30 is provided on bottom plate 103, and the top of electric cabinet drawer 30 is arranged in the function platform module 20.Institute
Stating platform structure 40 includes the horizontal panel 401 for placing article.In this example, the platform structure 40 is fixed on electric cabinet pumping
On the one side of drawer 30, therefore, when platform structure 40 is in 104 lower position of front panel, due to the limitation of platform structure 40,
Electric cabinet drawer 40 can not be extracted out from bottom plate 103, when platform structure 40 and electric cabinet drawer 30 together from extraction when, then formed as schemed
State shown in 5 can directly repair electric cabinet drawer 30 at this time, simplify the maintenance mode of electric cabinet drawer 30.Originally show
In example, the horizontal panel 401 of platform structure 40 provides the interim platform for placing reagent, consumptive material, when to function platform mould
During block 20 is operated manually, such as in the process for adding reagent manually to the sample area in function platform module 20
In, reagent can be temporarily placed on horizontal panel 401, when needing to continue to use reagent directly from horizontal panel 401
It takes, improves manually-operated efficiency.
For the function platform module 20, the invention proposes an example, the reagent work station includes shell 101
With function platform module 20, the shell includes bottom plate 103, and an electric cabinet drawer 30, and the function are provided on bottom plate 103
The top of electric cabinet drawer 30 is arranged in energy console module 20.The lower end of the platform structure 40 and the bottom plate 103, which rotate, to be connected
It connects, platform structure 40 includes being put for placing the horizontal panel 401 of article due to the presence of horizontal panel 401 for temporary needs
The reagent or consumptive material set provide a platform, during being operated manually to function platform module 20, such as right
During reagent is added manually in sample area in function platform module 20, reagent can be temporarily placed to horizontal panel 401
On, it is directly taken from horizontal panel 401 when needing to continue to use reagent, improves manually-operated efficiency.In this example
In, the platform structure 40 has closed state and open state, and as shown in Figure 6 a, as platform structure 40 is in close state
Structural schematic diagram, when platform structure 40 is in close state, the electric cabinet drawer 30 and function platform module 20 lean against institute
On the medial surface for stating platform structure 40, in the present solution, the shell 10 includes a front panel 104, the inside of platform structure 40
Face is also located against on the front panel 104.As shown in Figure 6 b, the as structural schematic diagram in the open state of platform structure 40,
When platform structure 40 is in the open state, electric cabinet drawer 30 can be extracted out from bottom plate 103, and therefore, platform structure 40 is set
Meter, is convenient to pull out electric cabinet drawer 30 from bottom plate 103 and is safeguarded and repaired, and platform structure 40 is electric cabinet drawer 30
Maintenance and maintenance provide window, simplify maintenance and the maintenance mode of electric cabinet drawer 30.In this example, the platform structure
40 section is fan-shaped, and in other schemes, the section of the platform structure 40 is rectangular, but it should be recognized that flat
Face structure 40 at least has the horizontal panel 401 for placing article, and the concrete shape of planar structure 40 can be according to actual needs
It is designed.
In addition, the function platform module 20 includes pedestal 201 and is arranged the bottom of in the example described in Fig. 6 a, Fig. 6 b
Multiple drawer units on seat, and drawer unit is used drawer-type structure and is mounted on pedestal 201 in the form of dismountable
On.When platform structure 40 is in the open state, multiple drawer units can also be extracted out directly from pedestal 201, when
When wherein some drawer unit breaks down, it can be repaired individually for each drawer unit, therefore platform structure 40
Also the maintenance for the drawer unit of function platform module 20 provides window, meanwhile, drawer unit is limited in by platform structure 40
The top of electric cabinet drawer when platform structure 40 is not opened, can not pull out drawer unit, improve the safety of drawer unit.When
When needing replacing drawer unit, after opening platform structure 40, directly drawer unit can be extracted out from pedestal 201, more renewed
Drawer unit after, it is very convenient directly by new drawer unit push-in pedestal 201.For the pumping of function platform module
Drawer unit, as shown in fig. 7, the multiple drawer units being arranged on pedestal 201 are respectively that reagent is deposited the invention proposes an example
Put unit 202, consumptive material unit 203, waste unit 204, reagent reaction member 205 and sample storage unit 206, wherein described
For consumptive material unit 203 for storing consumptive material, consumptive material includes but are not limited to magnetosheath, kit, V-groove, microwell plate；Waste unit
204 for storing generated waste material in the reagent work station course of work.The waste unit 204 includes band blood waste recovery group
Part 2041 and common waste recovery component 2042, it is described to be used to recycle the waste material with blood with blood waste recovery component 2041, it is described
Common waste recovery component 2042 is used to recycle the waste material in addition to the waste material with blood；The sample storage unit 206 is for depositing
Setting-out product are separately stored with other reagents, to avoid pollution；The reagent reaction member 205 is for the shifting through reagent work station 10
The solution of liquid module configuration is reacted.Reagent storage unit 202, consumptive material unit 203, waste unit 204, reagent reaction member
205 and sample storage unit 206 position and size can be set as needed；Therefore 20 region of function platform module then may be used
Arbitrary combination is realized as needed, and flexibility is more preferably.
Reagent storage unit 202, consumptive material unit 203, waste unit 204, reagent reaction member 205 and sample are stored
Unit 206, the invention proposes another specific embodiments, as shown in Figure 8 a, multiple drawer limits are provided on the pedestal 103
The quantity of component 2011, drawer limiting component 2011 need to be above-mentioned depending on the drawer unit quantity in function platform module 20
Reagent storage unit 202, consumptive material unit 203, waste unit 204, reagent reaction member 205 and sample storage unit 206 it is equal
It can be described as drawer unit 200.As shown in Figure 8 a, the spacing between each adjacent drawer limiting component 2011 is a, the drawer list
The width of member 200 is the integral multiple of a, is provided on 200 bottom surface of drawer unit and matches with drawer limiting component 2011
Drawer detent in embodiment shown in Fig. 8 a, is equipped with nine drawer limiting components 2011, the width of the first drawer unit 2001 in total
Degree is a, and the width of the second drawer unit 2002 is 3a, and the width of third drawer unit 2003 is 2a, the 4th drawer unit
2004 width is a, and the width of the 5th drawer unit 2005 is 2a, the first drawer unit 2001, the second drawer unit 2002,
Third drawer unit 2003, the 4th drawer unit 2004, the 5th drawer unit 2005 bottom surface on be provided at least one with
The drawer detent that drawer limiting component 2011 matches, such as 2001 bottom surface of the first drawer unit are equipped with a drawer detent, the
It is set on two drawer units, 2002 bottom surface there are three drawer detent, is set on 2003 bottom surface of third drawer unit there are two drawer detent,
4th 2004 bottom surface of drawer unit is equipped with a drawer detent, sets that there are two drawers on the 5th 2005 bottom surface of drawer unit
Detent.Certainly, the quantity of above-mentioned drawer detent is only used as a preferred embodiment, when being arranged two on the second drawer unit 2002
It, can't be to drawer unit 200 and bottom when a drawer detent is only set on a drawer detent or third drawer unit 2003
The cooperation of seat impacts.It should be understood that Fig. 8 a is only used as embodiment that the present invention is explained, drawer in Fig. 8 a
The quantity of unit 200 can be increased and decreased as needed.By the design to such structure of drawer unit 200, it can be achieved that each pumping
The Optional assembling of drawer unit 200 first turns to platform structure 40 when needing replacing wherein a certain 200 position of drawer unit
Drawer unit 200 is directly removed from pedestal 201 and is inserted into the position for needing to place by open state shown in Fig. 6 b, this
The limited space of function platform module 20 is adequately utilized in structure, realizes the optimization layout of function platform module 20.
In another embodiment, as shown in Figure 8 b, reagent storage unit 202, consumptive material unit 203, reagent reaction are single
Side by side, width is followed successively by 2a, 4a, 2a, a, a for member 205, sample storage unit 206 and waste unit 204.It is arranged on pedestal 201
There are multiple drawer limiting components 2011, reagent storage unit 202, consumptive material unit 203, reagent reaction member 205, sample storage are single
The bottom surface of member 206 and waste unit 204 is equipped at least one drawer detent cooperated with drawer limiting component 2011.This programme
In, the bottom surface of reagent storage unit 202 set there are two with drawer limiting component 2011 cooperate drawer detent, consumptive material unit 203
Bottom surface set that there are four the drawer detents cooperated with drawer limiting component 2011, there are two the bottom surface of example reaction unit 205 is set
The bottom surface of the drawer detent cooperated with drawer limiting component 2011, waste unit 204 and sample storage unit 205 is then respectively equipped with
One drawer detent cooperated with drawer limiting component 2011.This programme by drawer unit 200(reagent storage unit 202,
Consumptive material unit 203, waste unit 204, reagent reaction member 205 and sample storage unit 206 can be described as drawer unit 200)
Such structure designs the Optional assembling, it can be achieved that each drawer unit 200, is needing replacing wherein a certain drawer unit 200
When position, platform structure 40 is first turned into open state shown in Fig. 6 b, directly drawer unit 200 is removed and is inserted into needs
The position of placement, for example, as shown in Figure 8 b, in the position for needing for consumptive material unit 203 to be moved to 20 left end of function platform module
When setting, consumptive material unit 203 is removed from pedestal 201, by the consumptive material unit drawer detent of 203 bottom surface four and pedestal 201
Drawer limiting component 2011 cooperation, directly will be on the position of 203 inserted base of consumptive material unit, 201 left end.When reagent is deposited
Unit 202, waste unit 204, reagent reaction member 205 and sample storage unit 206 is put to need to be moved to position, it can also root
According to being set.The limited space of function platform module 20 is adequately utilized in this structure, realizes function platform mould
The optimization of block 20 is laid out.
In a specific embodiment of drawer limiting component 2011 and drawer detent, as illustrated in fig. 9, the drawer limit
Component 2011 is a conducting bar, and the drawer detent 2012 is a guide groove, needs to be transplanted on the position for needing to place in drawer unit 200
When setting, the insertion that directly matches the guide groove of drawer unit 200 with conducting bar.For drawer limiting component 2011 and drawer
The fit system of detent 2012 also has other forms, such as guide groove is arranged on bottom plate 201, and conducting bar is set to drawer
200 lower section of unit, can also similarly realize drawer unit disassembly and assembling.In another embodiment, as shown in figure 9b, institute
Stating drawer limiting component 2011 is the fixed column being fixed on pedestal 201, and drawer detent 2012 is to be set to 200 bottom of drawer unit
The fixation hole in portion, by the cooperation of fixed column and fixation hole, it can be achieved that the detachable fixation of drawer unit 200 and pedestal 201.
Further, 201 multiple interfaces 2013, the interface 2013 and reagent work are equipped on the pedestal of function platform module 20
Make the main control module connection at station 10, the reagent storage unit 202, consumptive material unit 203, waste unit 204, reagent reaction member
205 and 206 rear portion of sample storage unit be provided with the socket 2014 matched with the interface of pedestal 201.In a specific implementation
In example, as shown in Figure 10, on the basis of above-mentioned Fig. 8 a embodiment, the present invention proposes another embodiment, in the present solution, providing
Width be respectively the first drawer unit 2001 of a, 3a, 2a, a, 2a, second drawer unit 2002, third drawer unit 2003,
4th drawer unit 2004, the 5th drawer unit 2005, pedestal 201 is equipped with multiple interfaces 2013, between adjacent interface 2013
Spacing be a, the first drawer unit 2001, the second drawer unit 2002, third drawer unit 2003, the 4th drawer unit
2004, the socket 2014 matched with interface 2013 is then respectively equipped on the 5th drawer unit 2005；In addition, in the first drawer list
First 2001, second drawer unit 2002, third drawer unit 2003, the 4th drawer unit 2004 and the 5th drawer unit 2005
Front end all has the display device for showing connection status, and the display device is indicator light 2015, instruction in the present embodiment
Lamp 2015 is then for showing the first drawer unit 2001, the second drawer unit 2002, third drawer unit 2003, the 4th drawer list
Member 2004 and the 5th connection status with pedestal 201 respectively of drawer unit 2005 are carried out in drawer unit 200 with pedestal 201 slotting
When connecing, if drawer unit 200 is not inserted into designated position, socket and the interface on pedestal 201 of drawer unit 200 can not connect
It connects, main control module cannot then receive signal, then control instructions lamp 2015 lights (or extinguishing), issue drawer unit 200 and do not insert
The signal for entering or being not fully inserted into designated position, therefore can avoid due to the factor of 200 position of drawer unit to preparation of reagents
Caused by influence.In the present solution, the Optional assembling of each drawer unit 200 not only may be implemented, it is wherein a certain needing replacing
When 200 position of drawer unit, by opening platform structure 40, directly removing drawer unit 200 and being inserted into the position for needing to place
It sets, the limited space of function platform module 20 is adequately utilized, realize the optimization layout of function platform module 20；Each
Behind the corresponding position of 200 insertions function console module of drawer unit 20, a drawer unit 200 may also display by indicator light 2015
Connection status, so that it is guaranteed that each drawer unit 200 is inserted into specified position.
For the reagent work station with platform structure, as shown in figure 11, the invention proposes an example, the reagent work
Making station further includes liquid relief module 50 and main control module, and the liquid relief module 50 is located at the top in shell 101, for according to master control
The instruction realization of module pipettes reagent.Further, in this example, the reagent work station further includes nucleic acid extraction mould
Block 60, the nucleic acid extraction module 60 are located in shell, for realizing automatically extracting for nucleic acid according to the instruction of main control module, wrap
Include gear unit 601 and oscillating unit 602；The shell 10 of reagent work station further includes backboard 107, and the oscillating unit 602 is solid
It is scheduled on backboard 107, oscillating unit 602 is for being stirred the reagent in the container placed on gear unit 601；The biography
Moving cell 601 is set on pedestal 201, and between function platform module 20 and backboard 107, and gear unit 601 is for real
The movement of existing carried container, the gear unit 601 include the kit assembly line for being used for transmission the container for holding reagent.This
In 10 internal upper part of shell, liquid relief module 50 as required will by the control of main control module for the setting of liquid relief module 50 in example
Reagent is sent to designated position and is prepared, and realizes the automatic configuration of reagent；Gear unit 601 in nucleic acid extraction module 60
Cooperate with oscillating unit 602, the container for holding reagent is driven to 602 lower section of oscillating unit, oscillating unit by gear unit 601
602 are stirred the reagent in container, carry out reagent mixing, and then realize the extraction of nucleic acid；Therefore reagent of the invention
Work station has the function of nucleic acid extraction and preparation of reagents function simultaneously.
For nucleic acid extraction module 60, the present invention proposes a specific embodiment, and nucleic acid extraction module 60 includes gear unit
601 and oscillating unit 602, wherein movement of the gear unit 601 for realizing carried container, the gear unit 601
The kit assembly line of the container of reagent is held including being used for transmission, as shown in figure 12, the kit assembly line includes rotation
Main shaft 6011, driving wheel 6012, driven wheel 6013 and the transmission belt 6014 that rotation is driven by rotation main shaft 6011, pass
6014 sets of band are sent on driving wheel 6012 and driven wheel 6013, is rotated by the drive of driving wheel 6012, to drive transmission
Band 6014 rotates, and conveyer belt 6014 then realizes the movement of container.In this example, reagent work station is carried out high-throughput using paramagnetic particle method
Nucleic acid automatically extract, by the coordinating operation of kit assembly line and above-mentioned liquid relief module 50 can realize reagent liquid relief,
It dispenses and finally realizes that the automation of solution is prepared；Under the control of main control module, the pipeline system operation of kit can be realized
It moves back and forth, and oscillating unit 602 is cooperated to realize automatically extracting for nucleic acid, the reagent work station of the present embodiment has automatic simultaneously
The nucleic acid extraction and preparation of reagents function of change.The oscillating unit 602 is used for the examination in the container placed on gear unit 601
Agent is stirred.Oscillating unit 602 includes including two Z axis manipulators, magnetic head and magnetosheath, and two manipulators drive magnetic respectively
Head, magnetosheath move up and down in vertical direction.In one embodiment, two Z axis manipulators are Z axis screw rod transmission machine
Structure, one of Z axis lead-screw drive mechanism connect magnetic head, and driving magnetic head moves up and down, the connection of another Z axis lead-screw drive mechanism
Magnetosheath, driving magnetosheath move up and down, and when needing to realize Magneto separate, then magnetic head enters in magnetosheath, enter kit together and adsorb
Magnetic bead；When need pat mix when, magnetic head be located at it is upper motionless, magnetosheath decline self-movement carry out beating mix reagent.
Further, the container is detachably mounted on conveyer belt 6014.By way of being detachably fixed, a side
Face improves stationarity of the container when transmitting on conveyer belt 6014, on the other hand is needing to remove container from conveyer belt
When, the mode being detachably fixed of this programme will not impact removing for container.In one embodiment, as schemed
Shown in 13a, conveyer belt 6014 is equipped with the through-hole that diameter is slightly larger than container 70, is cased with snap ring 701 on container 70, the snap ring 701
Outer diameter be greater than the internal diameter of through-hole, therefore container can be shelved in through-hole, realized and transmitted by conveyer belt 6014, due to through-hole pair
Container has position-limiting action, ensure that stationarity when container transmission.In another embodiment, as illustrated in fig. 13b, container
70 bottom sides are equipped with a fixture block 702, and rotary buckle 703 is had on conveyer belt 6014, by the effect of rotary buckle 703,
Container 70 is fixed on conveyer belt 6014, rotary buckle 703 is then opened when needing to remove container 70, due to rotary buckle 703
Container 70 is fixed, guarantee stationarity when container 70 transmits.In another embodiment, as shown in figure 13 c, in conveyer belt
It is pasted with double-sided adhesive 704 on 6014 upper surfaces, container 70 is pasted on double-sided adhesive 704, this structure can also realize container 70
Detachable fixation.Container 70 is detachably fixed on conveyer belt 6014, ensure that container 70 on conveyer belt 6014
Stationarity when transmission, the container can be one or more of 96 orifice plates, deep-well plates, microwell plate, customization kit.In addition,
Kit assembly line lower part may be provided with the elevating mechanism that heat block, control heat block for heating to reagent move up and down, and pass through
Such structure such as needs to heat the liquid in container, then passes through the work of elevating mechanism during nucleic acid extraction
With control heat block rises, and realizes the heating to container.
For liquid relief module 50, the present invention proposes a specific embodiment, and the liquid relief module 50 may include can be in XYZ axis
The mobile manipulator in direction and fixed pipettor unit on a robotic arm.As shown in figure 14, the liquid relief module 50 includes
Manipulator 501 and fixed pipettor unit 502 on a robotic arm, wherein manipulator 501 is to realize pipettor unit 502
Tri- directions XYZ are mobile in casing, therefore various structures can be used in manipulator 501, such as: 1, it is real using belt-type structure
It is existing, mobile part-structure will be needed to be fixed on feed belt, feed belt rotation is driven by motor or motor, realizes and moves
Movement of the liquid device unit in XYZ axis direction；2, it is realized using screw driving type structure, mobile part-structure will be needed to be fixed on
On slide unit, by the cooperation of screw rod and slide unit, the movement of slide unit is converted by motor or motor, to realize pipettor
Unit is in the movement of XYZ axis direction, and certainly, the structure of manipulator 501 of the present invention is not limited in above-mentioned two kinds.
The reciprocating motion of the kit assembly line upper container of reagent work station of the present invention, passes through the cooperation of oscillating unit 602
It realizes the extraction of nucleic acid, while the reciprocating motion of kit assembly line upper container, can be achieved by the cooperation with liquid relief module 50
The liquid relief of reagent dispenses, and in addition there is liquid relief module 50 reagent to automate function equipment, therefore such reagent work of the invention
It stands while having the function of nucleic acid extraction and preparation of reagents function, solve in the prior art that nucleic acid extraction platform feature is single, only
Has the function of nucleic acid extraction, without having the problem of preparation of reagents function.It should be noted that reagent work station of the present invention, no
It can be considered as the equipment that will there is nucleic acid extraction function and the combination that simply carries out of equipment with preparation of reagents function, and it is existing
Unlike technology, reagent work station of the invention due to kit pipeline organization design, and kit assembly line with
The cooperation of liquid relief module 50, may be implemented liquid relief, the packing of reagent, while cooperate sealed in unit, realize automation encapsulation, therefore
The automation encapsulation of nucleic acid extraction, preparation of reagents and reagent may be implemented in reagent work station of the invention.In addition, single in oscillation
An anticollision mechanism can be set in the top position of member, which has contact-making switch, when the manipulator of liquid relief module 50
When moving to the location of oscillating unit, manipulator is touched first on the contact-making switch of anticollision mechanism, and contact-making switch is connected
Signal is then issued afterwards to main control module, and main control module is then sent corresponding instructions in liquid relief module, and control manipulator stops fortune
It is dynamic, while warning device can also be excited to issue alarm signal.
On the basis of above-mentioned any scheme, as shown in fig. 15 a, it is arranged on the horizontal panel 401 of the platform structure 40
There is the deep trouth 402 being recessed inwardly, the deep trouth 402 provides the region of a placement for interim placement reagent or consumptive material, when right
During function platform module 20 is operated manually, such as need for reagent or consumptive material to be temporarily placed on horizontal panel 40, then
It can be directly placed into deep trouth 402.In this example, the section of the deep trouth 402 is circle.It should be noted that the deep trouth
402 shape can be designed with size according to the reagent or consumptive material of required placement.
On the basis of above-mentioned any scheme, as illustrated in fig. 15b, it is arranged on the horizontal panel 401 of the platform structure 40
There is anti-skid chequer 403, horizontal panel 401 provides a platform for interim placement reagent or consumptive material.In the practical work of reagent work station
During work, reagent or consumptive material are generally needed to be placed in household freezer, and the container for holding reagent or consumptive material takes out from household freezer
Afterwards, surface can condense out water droplet, if directly the container for holding reagent or consumptive material is placed on horizontal panel 401 at this time, hold
The case where device easily slides.Therefore, by the way that anti-skid chequer 403 is arranged on horizontal panel 401, increase container bottom and horizontal plane
Frictional force between plate 401, the case where being slid from horizontal panel 401 to avoid container.
On the basis of above-mentioned any scheme, the more of different model are provided on the platform structure 40, equipment is locked, institute
It states equipment and locks shell 101 for platform structure 40 to be locked in reagent work station 10.For example, the example shown in Fig. 3 a
In, the equipment lock of two different models is set at the both ends of platform structure 40, is locked in platform structure 40 outside by equipment lock
On the front panel 104 of shell 101, in the case where being not switched on equipment lock, platform structure 40 and protective door 105 can not be pushed up,
Therefore platform structure 40 and protective door 105 can not form state shown in Fig. 3 b, and electric cabinet drawer 30 can not then be taken out from bottom plate 103
Out, the safety of equipment is improved.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (10)
1. a kind of reagent work station with platform structure, it is characterised in that: the reagent work station includes that shell and function are flat
Platform module, the shell include bottom plate, and an electric cabinet drawer is provided on the bottom plate, and the function platform module is arranged in electric cabinet
The top of drawer；
The platform structure is movably arranged on the shell, which is used to control the electric cabinet drawer in bottom plate
Realize extraction or push-in；The platform structure includes the horizontal panel for placing article, is provided on the horizontal panel anti-
It slides line or is provided with the groove for placing container.
2. the reagent work station according to claim 1 with platform structure, it is characterised in that: under the platform structure
End is rotatablely connected with the bottom plate.
3. the reagent work station according to claim 1 with platform structure, it is characterised in that: the shell includes front
Plate, is provided with protective door on the front panel, and the bottom end of the platform structure and protective door connects.
4. the reagent work station according to claim 1 with platform structure, it is characterised in that: the platform structure is fixed
On the one side of electric cabinet drawer.
5. the reagent work station according to claim 1 with platform structure, it is characterised in that: the function platform module
Including pedestal, reagent storage unit, consumptive material unit, waste unit, reagent reaction member and sample storage unit, the reagent is deposited
It puts unit, consumptive material unit, waste unit, reagent reaction member and sample storage unit and is all made of drawer-type structure and with removable
The form unloaded is mounted on the base.
6. the reagent work station according to claim 5 with platform structure, it is characterised in that: the function platform module
On be provided with multiple drawer limiting components, the spacing between each adjacent drawer limiting component is a, the reagent storage unit,
Consumptive material unit, waste unit, reagent reaction member and sample storage unit width be the integral multiple of a；The reagent storage
It is provided with and drawer limiting component on unit, consumptive material unit, waste unit, reagent reaction member and sample storage unit bottom surface
The drawer detent of cooperation.
7. the reagent work station according to claim 1 with platform structure, it is characterised in that: the reagent work station is also
Including liquid relief module and main control module, the liquid relief module is located at the top in shell, for real according to the instruction of main control module
Now reagent is pipetted.
8. the reagent work station according to claim 7 with platform structure, it is characterised in that: the reagent work station is also
Including nucleic acid extraction module, the nucleic acid extraction module is located in shell, for realizing nucleic acid according to the instruction of main control module
It automatically extracts, including gear unit and oscillating unit；Movement of the gear unit for realizing carried container, the transmission
Unit includes the kit assembly line for being used for transmission the container for holding reagent；The oscillating unit is used for placing on gear unit
Container in reagent be stirred.
9. the reagent work station according to claim 8 with platform structure, it is characterised in that: the kit assembly line
Including conveyer belt, the container is detachably mounted on conveyer belt.
10. according to claim 1 with the reagent work station of platform structure described in -9 any claims, it is characterised in that:
It is provided with the more of different model on the platform structure to lock equipment, the equipment lock is for being locked in reagent work for platform structure
Make on the shell stood.
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| CN201510705215.8A CN106609237B (en) | 2015-10-27 | 2015-10-27 | Reagent work station with platform structure |
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|---|---|---|---|
| CN201510705215.8A CN106609237B (en) | 2015-10-27 | 2015-10-27 | Reagent work station with platform structure |
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| CN106609237B true CN106609237B (en) | 2019-07-02 |
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| CN108693344A (en) * | 2018-03-27 | 2018-10-23 | 桂林优利特医疗电子有限公司 | Blood testing instrument carriage |
| CN109270261A (en) * | 2018-09-19 | 2019-01-25 | 上海裕隆神光医学检验实验室有限公司 | A kind of magnetic bead chemiluminescence detection kit |
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| CN2590054Y (en) * | 2002-12-12 | 2003-12-03 | 上海港口技术工程服务有限公司 | Computer operated mobile workstation |
| CN101332439A (en) * | 2007-06-26 | 2008-12-31 | 上海裕隆生物科技有限公司 | Automatic liquor removing workstation |
| CN201662901U (en) * | 2009-12-17 | 2010-12-01 | 亚龙科技集团有限公司 | Singlechip intelligent detection control equipment |
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| CN103789198A (en) * | 2014-02-27 | 2014-05-14 | 苏州天隆生物科技有限公司 | Full automatic instrument for extracting nucleic acids |
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| JP5872734B2 (en) * | 2013-03-29 | 2016-03-01 | 中国電力株式会社 | Sustain flow power generation control system, maintenance flow power generation control method, maintenance flow power generation control program, and maintenance flow power generation facility |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2590054Y (en) * | 2002-12-12 | 2003-12-03 | 上海港口技术工程服务有限公司 | Computer operated mobile workstation |
| CN101332439A (en) * | 2007-06-26 | 2008-12-31 | 上海裕隆生物科技有限公司 | Automatic liquor removing workstation |
| CN201662901U (en) * | 2009-12-17 | 2010-12-01 | 亚龙科技集团有限公司 | Singlechip intelligent detection control equipment |
| CN201994572U (en) * | 2011-01-28 | 2011-09-28 | 中国石油化工股份有限公司 | Feed cabinet and extraction type oil well centralized control power supply device |
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