CN106604724A - 用于减少局部脂肪与减少体重的组合物及其医药品与应用 - Google Patents

用于减少局部脂肪与减少体重的组合物及其医药品与应用 Download PDF

Info

Publication number
CN106604724A
CN106604724A CN201580045335.8A CN201580045335A CN106604724A CN 106604724 A CN106604724 A CN 106604724A CN 201580045335 A CN201580045335 A CN 201580045335A CN 106604724 A CN106604724 A CN 106604724A
Authority
CN
China
Prior art keywords
fat
composition
pharmaceuticals
body weight
reducing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201580045335.8A
Other languages
English (en)
Other versions
CN106604724B (zh
Inventor
凌玉芳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Caliway Biopharmaceuticals Co Ltd
Original Assignee
Caliway Biopharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caliway Biopharmaceuticals Co Ltd filed Critical Caliway Biopharmaceuticals Co Ltd
Publication of CN106604724A publication Critical patent/CN106604724A/zh
Application granted granted Critical
Publication of CN106604724B publication Critical patent/CN106604724B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/06—Preparations for care of the skin for countering cellulitis

Abstract

本发明公开一种用于减少局部脂肪与减少体重的组合物及其医药品与应用，所述组合物包括重量比为1∶30至10∶1的白藜芦醇与姜黄萃取物，本发明所述的组合物及其医药品可抑制脂肪细胞生长，并造成脂肪细胞计划性的凋亡，达到减少脂肪细胞、减少局部脂肪堆积及减少体重的效果，而不会引起周边细胞与组织的发炎反应或组织坏死，亦无外围组织的炎症或疼痛反应，进而避免现有技术利用抽脂手术或低侵入的溶脂仪器所造成的组织受损与发炎疼痛问题，也不会有溶脂注射剂成分磷脂胆碱(phosphatidylcholine)或是脱氧胆酸钠(sodium deoxycholate)造成细胞崩解坏死(necrosis)所引发的外围组织发炎与坏死感染等问题。

Description

PCT国内申请，说明书已公开。

Claims (12)

  1. PCT国内申请，权利要求书已公开。
CN201580045335.8A 2014-08-28 2015-08-28 用于减少局部脂肪与减少体重的组合物及其医药品与应用 Active CN106604724B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462042864P 2014-08-28 2014-08-28
US62/042,864 2014-08-28
PCT/CN2015/088340 WO2016029870A1 (zh) 2014-08-28 2015-08-28 用于减少局部脂肪与减少体重的组合物及其医药品与应用

Publications (2)

Publication Number Publication Date
CN106604724A true CN106604724A (zh) 2017-04-26
CN106604724B CN106604724B (zh) 2020-05-26

Family

ID=55398772

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580045335.8A Active CN106604724B (zh) 2014-08-28 2015-08-28 用于减少局部脂肪与减少体重的组合物及其医药品与应用

Country Status (17)

Country Link
US (1) US9987325B2 (zh)
EP (2) EP3811935A1 (zh)
JP (1) JP6473505B2 (zh)
KR (2) KR101859345B1 (zh)
CN (1) CN106604724B (zh)
AU (2) AU2015309353B2 (zh)
CA (1) CA2959185C (zh)
DK (1) DK3187178T3 (zh)
ES (1) ES2924879T3 (zh)
HU (1) HUE059878T2 (zh)
MX (2) MX2017002585A (zh)
PL (1) PL3187178T3 (zh)
PT (1) PT3187178T (zh)
SG (1) SG11201701476PA (zh)
SI (1) SI3187178T1 (zh)
TW (1) TWI580422B (zh)
WO (1) WO2016029870A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160129068A1 (en) * 2014-11-10 2016-05-12 Caliway Biomedical Co., Ltd. Composition of plant extract and its pharmaceutical composition and application thereof
AU2016314546C1 (en) 2015-08-28 2021-07-22 Caliway Biopharmaceuticals Co., Ltd. Pharmaceutical composition used for reducing localised fat and use of pharmaceutical composition
US11318110B2 (en) 2015-08-28 2022-05-03 Caliway Biopharmaceuticals Co., Ltd. Pharmaceutical composition for reducing local fat and uses thereof
CA3033041A1 (en) * 2016-08-26 2018-03-01 Caliway Biopharmaceuticals Co., Ltd. A subcutaneous injection formulation for reducing body weight and uses thereof
WO2018144911A1 (en) * 2017-02-02 2018-08-09 Golo Llc Formulations for weight loss and methods of use
KR102093872B1 (ko) 2017-07-03 2020-03-27 진호성 지방제거용 주사제 조성물 및 이의 제조방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6475530B1 (en) * 2000-05-31 2002-11-05 Eric H. Kuhrts Methods and compositions for producing weight loss
CN101632655A (zh) * 2009-08-04 2010-01-27 南京大渊美容保健有限公司 延缓衰老的白藜芦醇和生物类黄酮营养组合物
CN102357226A (zh) * 2007-08-07 2012-02-22 北京北大维信生物科技有限公司 中草药姜黄提取物在制备减肥降脂药物或制备具有脂肪酶活性抑制作用的药物中的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040146539A1 (en) * 2003-01-24 2004-07-29 Gupta Shyam K. Topical Nutraceutical Compositions with Selective Body Slimming and Tone Firming Antiaging Benefits
EP1708689A2 (en) * 2003-12-29 2006-10-11 The President and Fellows of Harvard College Compositions for treating or preventing obesity and insulin resistance disorders
ITFI20050031A1 (it) 2005-02-21 2006-08-22 Stefan Coccoloni Una composizione farmaceutica atta a prevenire l'invecchiamento e l'insorgere di malattie vascolari,neoplastiche,cutanee e dell'apparato pilifero
WO2007041276A2 (en) 2005-09-29 2007-04-12 New Chapter, Inc. Methods for modulating apoptosis, cellgrowth, and protein expression with herbal compositions
JP2007131603A (ja) * 2005-11-14 2007-05-31 Kaneka Corp Ｌ−カルニチン合成系酵素遺伝子の転写促進用組成物
EA200802090A1 (ru) * 2006-03-31 2010-04-30 ДСМ АйПи АССЕТС Б.В. Новое применение соединений и комбинаций соединений для улучшения внешнего вида
US7977319B1 (en) 2006-04-03 2011-07-12 Scott David Levine Ultra-high fiber supplement and method of reducing weight, cardiovascular risks and ingested toxins
CN101095665A (zh) * 2006-06-27 2008-01-02 中国科学院上海生命科学研究院 Sirt1在预防、控制或治疗肥胖中的用途
CN102066397B (zh) 2008-04-18 2013-09-11 里亚塔医药公司 包含抗炎症药效团的化合物以及使用方法
AU2009307753A1 (en) 2008-10-22 2010-04-29 Metaproteomics, Llc Novel mitochondrial uncoupling methods and compositions for enhancing adipocyte thermogenesis
JP5594819B2 (ja) * 2009-12-22 2014-09-24 キリンホールディングス株式会社 脂質代謝改善用組成物
WO2012003176A1 (en) 2010-07-02 2012-01-05 Helix Biomedix, Inc. N-acyl amino acid derivatives for treating skin conditions such as cellulite
US8815310B2 (en) 2011-01-10 2014-08-26 Morteza Naghavi Compositions for boosting metabolism, assisting weight loss, and promoting cardiovascular health
EP2799081A4 (en) 2011-12-27 2015-06-24 Tokiwa Phytochemical Co Ltd SIRTUIN ACTIVATOR
US8496979B1 (en) 2012-02-02 2013-07-30 Reliv International, Inc. Caffeine-free dietary supplements for increasing energy and methods of administering the same
US8652518B2 (en) 2012-04-15 2014-02-18 Jahahreeh Finley Compositions and methods for the prevention and treatment of diseases or conditions associated with oxidative stress, inflammation, and metabolic dysregulation
US9211298B2 (en) * 2012-11-16 2015-12-15 Song Gao Compositions containing enriched natural crocin and/or crocetin, and their therapeutic or nutraceutical uses
MX2017002584A (es) * 2014-08-28 2017-05-25 Caliway Biopharmaceuticals Co Ltd Composicion y producto medicinal para reducir peso corporal y grasa corporal, y uso del producto.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6475530B1 (en) * 2000-05-31 2002-11-05 Eric H. Kuhrts Methods and compositions for producing weight loss
CN102357226A (zh) * 2007-08-07 2012-02-22 北京北大维信生物科技有限公司 中草药姜黄提取物在制备减肥降脂药物或制备具有脂肪酶活性抑制作用的药物中的应用
CN101632655A (zh) * 2009-08-04 2010-01-27 南京大渊美容保健有限公司 延缓衰老的白藜芦醇和生物类黄酮营养组合物

Also Published As

Publication number Publication date
AU2019201635B2 (en) 2021-01-28
JP6473505B2 (ja) 2019-02-20
DK3187178T3 (da) 2022-08-22
TWI580422B (zh) 2017-05-01
US20170157193A1 (en) 2017-06-08
PL3187178T3 (pl) 2022-11-21
MX2017002585A (es) 2017-05-25
TW201707695A (zh) 2017-03-01
WO2016029870A1 (zh) 2016-03-03
EP3187178B1 (en) 2022-06-08
KR20180052785A (ko) 2018-05-18
EP3811935A1 (en) 2021-04-28
SG11201701476PA (en) 2017-03-30
KR101859345B1 (ko) 2018-05-18
PT3187178T (pt) 2022-06-21
MX2021010638A (es) 2021-09-28
CA2959185A1 (en) 2016-03-03
SI3187178T1 (sl) 2022-10-28
AU2019201635A1 (en) 2019-04-04
KR101935219B1 (ko) 2019-01-03
JP2017525772A (ja) 2017-09-07
EP3187178A4 (en) 2018-02-14
KR20170043657A (ko) 2017-04-21
AU2015309353A1 (en) 2017-03-16
EP3187178A1 (en) 2017-07-05
CA2959185C (en) 2021-03-02
ES2924879T3 (es) 2022-10-11
CN106604724B (zh) 2020-05-26
AU2015309353B2 (en) 2018-12-20
HUE059878T2 (hu) 2023-01-28
US9987325B2 (en) 2018-06-05

Similar Documents

Publication Publication Date Title
US10226503B2 (en) Plant extract composition for reducing topical fat and promoting weight loss as well as applications thereof
AU2019201635B2 (en) Composition for reducing local fat and body weight, and pharmaceuticals and use thereof
KR20160064966A (ko) 화학요법제 보조에 사용하는 의약 조성물 및 그 용도
EP2723348B1 (en) Method for treating obesity
CN100394919C (zh) 一种用于治疗阴道疾病的药物组合物
US11752160B2 (en) Method for reducing fat by administering benzenesulfonamide compositions
CN114588164A (zh) 瑞马唑仑在预防围术期低体温和寒战中的应用
CN105232617A (zh) 黄芪总苷在制备预防或治疗微波辐射致神经细胞损伤药物中的用途、药物组合物及食品
CN115400137B (zh) 香蜂草苷在制备治疗骨关节炎药物中的应用
CN115252621B (zh) 一种小分子化合物在制备治疗骨关节炎药物中的应用
US20240009250A1 (en) Therapeutic application of cell-free fat extract to arthritis
RU2784896C2 (ru) Медицинское применение анемозида b4 против острого подагрического артрита
CN112294779A (zh) 糖基修饰多酚化合物预防和治疗急性肾损伤的新用途
CN102091326B (zh) 治疗因肛门皮下的静脉丛发生扩大或曲张所引发的痔类疾病的经皮给药制剂及制备方法
CN114146086A (zh) 维替泊芬在制备抗癌性疼痛的药物中的应用
CN117379412A (zh) 一种消退素结合透明质酸复合物及其制备方法
KR20220115413A (ko) 지방분해 효과가 개선된 데옥시콜산 조성물 및 이의 제조 방법
CN113289003A (zh) 一种干细胞因子组合物及其用途
CN115887439A (zh) 一种化合物在制备多囊卵巢综合征卵巢保护药物中的应用
CN117017936A (zh) 一种糖苷类化合物微乳软胶囊及其制备方法
CN113577051A (zh) 一种维拉帕米在制备保护软骨细胞缓解骨关节炎的产品中的应用
CN103127151A (zh) Gypensapogenin A在治疗急性肾衰药物中的应用
CN108379272A (zh) 猪去氧胆酸在制备减肥以及治疗或预防肥胖并发症药物中的应用
CN105232641A (zh) 赤芍总苷在制备预防或治疗微波辐射致神经细胞损伤药物中的用途、药物组合物及食品

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information
CB02 Change of applicant information

Address after: Chinese Taiwan New Taipei City

Applicant after: Kang Peisheng Limited by Share Ltd

Address before: Taipei City, Taiwan, China

Applicant before: Kang Peisheng Limited by Share Ltd

GR01 Patent grant
GR01 Patent grant