CN106581655A - Compound levoflorfenicol solid dispersant and preparation method thereof - Google Patents
Compound levoflorfenicol solid dispersant and preparation method thereof Download PDFInfo
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- CN106581655A CN106581655A CN201710000370.9A CN201710000370A CN106581655A CN 106581655 A CN106581655 A CN 106581655A CN 201710000370 A CN201710000370 A CN 201710000370A CN 106581655 A CN106581655 A CN 106581655A
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- florfenicol
- lysozyme
- levoflorfenicol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Abstract
The invention discloses a compound levoflorfenicol solid dispersant and a preparation method thereof. The solid dispersant comprises, by weight, 1.0-2.0% of Eudragit S-100, 0.2 to 0.5% of sodium bisulfite, 5 to 20% of levoflorfenicol, 0.5 to 1% of lysozyme, 0.5 to 1% of aesculetin, 2 to 5% of povidone and the balance anhydrous glucose. The compound levoflorfenicol solid dispersant retains the curative effect of levoflorfenicol and prevents the disadvantages of the too high concentration of local release of a common enteric-coated preparation. The lysozyme can improve the antibacterial activity of the product and remarkably improve the bioavailability. The product has good palatability, has no gastrointestinal irritation, can greatly enhance the cure rate, can form sustained release and absorption in the intestinal tract, keeps a blood drug concentration in the treatment level for a long time, does not stimulate the stomach and intestine, does not damage the liver, reduces the liver first-pass effects, has the highest drug utilization rate, can adjust immune functions and can recover macrophage immune activity.
Description
Technical field
The invention belongs to veterinary drug pharmaceutical technology field, more particularly to a kind of left-handed florfenicol solid dispersion of compound recipe and
Its preparation method.
Background technology
Florfenicol is the special chloromycetin broad-spectrum antiseptic of a kind of new veterinary successfully developed in the late nineteen eighties
Medicine, is also to treat one of optimal drug of respiratory complication at present.Existing florfenicol formulations mainly based on folk prescription, face
Big using there is using dosage on bed, using effect is not obvious, often due to therapeutic effect is slow, affects treatment disease adversely most
On good opportunity, to aquaculture heavy losses are brought.Therefore being badly in need of research one kind can improve drug effect, and the florfenicol of reduces cost is answered
Square preparation.Florfenicol is chloromycetin broad spectrum antibiotic, and it is combined with lysozyme, it is possible to increase drug effect, reduces florfenicol
Consumption, and reduce side effect, improve safety.
Florfenicol has a very big practical value, but also there are problems that one it is insoluble, that is, be insoluble in water,
Utilization rate is low, it is impossible to give full play to drug effect, while traditional florfenicol bitter in the mouth, also with gastrointestinal irritation.Current fluorobenzene
Buddhist nun examines dosage form tablet, powder, injection, suspensoid etc..But big multi-pharmaceuticss need multiple dosing to be had remaining sufficiently long
Effect drug level, and repetitively administered increases can administration cost, and cause animal stress reaction.Although and suspensoid can reach
To good utilization ratio of drug, however, due to the presence of water in liquid preparation, the stability of its preparation Shortcomings all the time, note
Penetrate agent to there is a problem of in-convenience in use and high cost.The absorption site of left-handed florfenicol in gastrointestinal upper end, in order to
Overcome its stomach irritation and acid labile, therefore its most preferred dosage form should be a kind of enteric coated preparation, said preparation has under one's belt portion
Subrelease is put, and usual 10%～50%, stimulation of the medicine to stomach so can have both been avoided, optimal Mlc can be reached again
Play the purpose of rapid-onset.With the wriggling of stomach, remaining part medicine can gradually pass through pylorus in intestinal, in intestinal
Dissolve in the presence of suitable pH value, discharge medicine, make medicine enter body-internal-circulation system, keep the balance of blood drug level.
Therefore, a kind of left-handed florfenicol oral formulations with good palatability, good stability and with double release functions are prepared
The edible comfortableness of the medicine will be greatly improved.
Solid dispersion technology is medicine to be dispersed in solid carrier in forms such as microgranule, crystallite or molecularities
One new formulation technology.
Lysozyme (lysozyme), also known as muramidase (muramidase) or the hydrolysis of N- acetyl mureins polysaccharide
Enzyme (N-acetylmuramide lycanohydrlase), is that one kind is widely present in milk, saliva, tear, Ovum Gallus domesticus album and fish
Native enzyme in ovum, with Efficient antibacterial, sterilization, antiviral biological activity.It can decompose killing such as staphylococcuses
The gram positive bacterias such as category, Streptococcus.Can be as a kind of sterilization and nourishing additive agent, in medicine, food and biochemical field
Extensively application, wide market.Due to the more prominent high efficiency in terms of the pharmacological effects such as antiviral, bactericidal antiphlogistic of the enzyme and
Popularity, becomes the focus of biomedicine field research.
The content of the invention
It is an object of the invention to provide preparing a kind of with good palatability, good stability and with double release functions
The left-handed florfenicol solid dispersion of compound recipe, and left-handed florfenicol principal agent effect can be strengthened, reduce side effect.
In order to realize object above, the technical solution adopted in the present invention is：A kind of left-handed florfenicol solid point of compound recipe
Powder, the composition and parts by weight of the compound solid dispersant are：Left-handed florfenicol 5-20%, lysozyme 0.5-1%, Cortex Fraxini second
Plain 0.5-1%, Eudragit RS 100 S-100 1.0-2.0%, sodium sulfite 0.2-0.5%, polyvidone 2-5%, balance of anhydrous glucose.
A kind of preparation method of the left-handed florfenicol solid dispersion of compound recipe, comprises the following steps：
（ 1）Full dose Eudragit RS 100 S-100 dissolves in ethanol, and clear solution is presented after stirring 30-60 minutes；
（ 2）Sodium sulfite and left-handed florfenicol, dissolving is added to shear 30 minutes into high speed shear homogenizer；
（ 3）Proceed to again in vacuum drying oven, temperature is maintained at 60 DEG C to being dried, and takes out, and grinds 80 mesh sieves, obtains carrier
Core layer；
（ 4）Then polyvidone, lysozyme, aesculetin and the anhydrous glucose of recipe quantity are put into respectively, use suitable after mix homogeneously
Amount pure water granulation；
（ 5）60 DEG C of dryings, granulate obtains final product the left-handed florfenicol solid dispersion of compound recipe.
Because left-handed florfenicol taste is extremely bitter, and scent of, palatability is poor；On the other hand, meter Kao Xing is unstable under one's belt,
It is degradable and there is zest to gastric mucosa, the ill symptomses such as anorexia, the Nausea and vomiting of poultry can be caused in administration process,
Even some animals smell the taste of left-handed florfenicol and just be unwilling to take food, and cause the failure being administered.The present invention is using solid point
The left-handed florfenicol water soluble of scattered technology increases, and bioavailability is improved, at the same mask left-handed florfenicol bitterness and
Zest, increased palatability, and the double delivery systmes of creative invention, said preparation has under one's belt part to discharge, and usual 10%
～50%, stimulation of the medicine to stomach so can have both been avoided, optimal Mlc can be reached again plays rapid-onset
Purpose.With the wriggling of stomach, remaining part medicine can gradually pass through pylorus in intestinal, in the work of the suitable pH value of intestinal
Lower dissolving is used, medicine is discharged, makes medicine enter body-internal-circulation system, keep the balance of blood drug level.
Aesculetin is in itself a kind of antimicrobial drug, has inhibitory action to dysentery bacterium, can be used to treat acute bacillary dysentery, and is had
Relieving asthma, phlegm-dispelling functions.Simultaneously as adjuvant, the mechanism for strengthening immunne response is the physical form by changing antigen, extends anti-
Original retention time in body；Stimulate submission ability of the mononuclear phagocyte to antigen；Stimulate lymphocyte differentiation, increase and expand
Immunne response ability.
Lysozyme is the biological nonspecific immunity factor important in vivo, with antibacterial, antiviral, enhancing immunity and rush
Enter the multi-functionals such as wound tissue's reparation.From the point of view of lysozyme practical application effect, often than laboratory good antimicrobial effect very
It is many.Its main cause is：Lysozyme has good biocompatibility, not only direct hydrolysis malignant bacteria cell wall, Er Qiehe
Other multi-element biologic agents in combination effects in animal body, press down bactericidal, neutralize a toxin, and health invigorating promotes growth；Secondly,
Environment meets the best use of condition of lysozyme just in animal body.And under lab, also do not possess and preferably embody molten
The simulation experiment of effect in bacterium enzyme animal body.
The present invention selects left-handed florfenicol and lysozyme perfect adaptation, can reach the effect of the high curative effect of low dosage, is coated with
Left-handed florfenicol, reduces destruction of the gastric acid to left-handed florfenicol, while slow release is formed in intestinal absorbing, makes blood drug level
Therapeutic dose is maintained for a long time；Targeting technology, makes medicine in the concentration of pulmonary higher than other positions, extensive with immunologic function is reconciled
Multiple macrophage immunity activity, can well treat respiratory tract disease, purify the secondary pig of sow group, pass breast, mycoplasma, streptococcus
Deng bacterial disease.
Combining with lysozyme coating and solid dispersion technology for the invention, significantly improves left-handed fluorobenzene Buddhist nun
The stability examined, improves bioavailability, reaches the effect of double releases, without gastrointestinal irritation, good palatability, while reducing
Toxic and side effects.
Compared to existing technology, the beneficial effects of the present invention is：
(1) solid dispersion technology is adopted with the effect of covering of the bag using carrier, delay the hydrolysis and oxidation of left-handed florfenicol, improve
Medicine stability；Double delivery systmes, can both reach the purpose that optimal Mlc plays rapid-onset, turn avoid general
The drawbacks of enteric coated preparation local delivery of drug excessive concentration；Cover adverse drug abnormal smells from the patient and zest；Good dispersion, greatly accelerates medicine
Dissolution, improve the bioavailability of medicine, make a kind of quick-acting, efficient preparation；
(2) solid dispersion of bacteriolyze ferment treatment, due to the coated potentiation of lysozyme, the antibacterial activity of left-handed florfenicol
2 times are improved, palatability is in good taste, the sensation without bitter in the mouth, and is very beneficial to pipe intestinal protection and alimentation, solve antibiotic
Not by gastric acid destruction, protective rate 98%, to gastrointestinal mucosa without destruction, while solid disperses, duration of efficacy is long, improves
The absorption of medicine and bioavailability, targeting is strong, makes medicine be significantly higher than other positions in the concentration of pulmonary, exempts from conciliation
Epidemic disease function, recovers macrophage immunity activity；(3) answering with left-handed florfenicol, aesculetin and lysozyme as main component
Square preparation, overcomes the shortcoming that existing single preparations of ephedrine compound preparation effect is poor, consumption is big, residual is high；Left-handed florfenicol and the Qin
Two kinds of Drug combinations of skin B prime, can greatly improve drug susceptibility, compared with single drug, be greatly decreased dosage and
Times for spraying, while improving curative effect of medication, reduces the using dosage of antibiotic, reduces toxic and side effects of the medicine to animal
Risk is remained using the potential drug that process may occur with medicine, has good application prospect in field of veterinary；
(4) coordinate aesculetin potentiation, and have relieving asthma, phlegm-dispelling functions；
(5) relative to injection, high cost, in-convenience in use, solid dispersion can be used with spice or drinking-water, be used simply,
Beneficial to large-scale cultivation.
Specific embodiment
The specific embodiment of the present invention is illustrated with reference to specific embodiment, but following examples are used only in detail
The present invention is illustrated, and limits the scope of the present invention never in any form.
Embodiment 1
A kind of left-handed florfenicol solid dispersion of compound recipe, component and correspondence percentage by weight are：Left-handed florfenicol 5%, bacteriolyze
Enzyme 0.5%, aesculetin 0.5%, Eudragit RS 100 S-100 1.0%, sodium sulfite 0.2%, polyvidone 2%, balance of anhydrous grape
Sugar.
The preparation method of the left-handed florfenicol solid dispersion of the compound recipe, concretely comprises the following steps：Full dose Eudragit RS 100 S-100 is molten
In the ethanol of 10 times of weight, stirring is presented clear solution to solution after 30 minutes, adds sodium sulfite and left-handed florfenicol, molten
Solution, after shearing 30 minutes into high speed shear homogenizer, in proceeding to vacuum drying oven, temperature is maintained at 60 DEG C to being dried, and takes out,
80 mesh sieves were ground, carrier core layer was obtained.Then polyvidone, lysozyme, aesculetin and the nothing of recipe quantity are put into respectively
Water glucose, is pelletized after mix homogeneously with appropriate purified water, and 60 DEG C of dryings, granulate obtains final product the left-handed florfenicol of graininess compound recipe
Solid dispersion；Wherein purified water accounts for the 2% of the left-handed florfenicol solid dispersion of graininess compound recipe.
Embodiment 2
A kind of left-handed florfenicol solid dispersion of compound recipe, component and correspondence percentage by weight are：Left-handed florfenicol 10%, it is molten
Bacterium enzyme 0.8%, aesculetin 0.8%, Eudragit RS 100 S-100 1.5%, sodium sulfite 0.4%, polyvidone 3%, balance of anhydrous grape
Sugar.
The preparation method of the left-handed florfenicol solid dispersion of the compound recipe, concretely comprises the following steps：By total amount Eudragit RS 100 S-100
It is dissolved in the ethanol by 30 times of its weight, stirring is presented clear solution after 40 minutes, adds sodium sulfite and left-handed fluorobenzene
Buddhist nun examines, dissolving, and after shearing 30 minutes into high speed shear homogenizer, in proceeding to vacuum drying oven, temperature is maintained at 60 DEG C and extremely does
It is dry, take out, 80 mesh sieves were ground, obtain carrier core layer.Then polyvidone, lysozyme, the Cortex Fraxini of recipe quantity are put into respectively
B prime and anhydrous glucose, are pelletized after mix homogeneously with appropriate purified water, and 60 DEG C of dryings, granulate obtains final product graininess compound recipe left-handed
Florfenicol solid dispersion；Wherein purified water accounts for the 3% of the left-handed florfenicol solid dispersion of graininess compound recipe.
Embodiment 3
A kind of left-handed florfenicol solid dispersion of compound recipe, component and correspondence percentage by weight are：Left-handed florfenicol 10%, it is molten
Bacterium enzyme 1.0%, aesculetin 1.0%, Eudragit RS 100 S-100 1.5%, sodium sulfite 0.4%, polyvidone 3%, balance of anhydrous grape
Sugar.
The preparation method of the left-handed florfenicol solid dispersion of the compound recipe, concretely comprises the following steps：By the dissolving of Eudragit RS 100 S-100
In the ethanol equivalent to 50 times of its weight, stirring is presented clear solution after 40 minutes, adds sodium sulfite and left-handed fluorobenzene
Buddhist nun examines, dissolving, and after shearing 30 minutes into high speed shear homogenizer, in proceeding to vacuum drying oven, temperature is maintained at 60 DEG C and extremely does
It is dry, take out, 80 mesh sieves were ground, obtain carrier core layer.Then polyvidone, lysozyme, the Cortex Fraxini of recipe quantity are put into respectively
B prime and anhydrous glucose, are pelletized after mix homogeneously with appropriate purified water, and 60 DEG C of dryings, granulate obtains final product graininess compound recipe left-handed
Florfenicol solid dispersion；Wherein purified water accounts for the 4% of the left-handed florfenicol solid dispersion of graininess compound recipe.
Embodiment 4
A kind of left-handed florfenicol solid dispersion of compound recipe, component and correspondence percentage by weight are：Left-handed florfenicol 20%, it is molten
Bacterium enzyme 1.0%, aesculetin 1.0%, Eudragit RS 100 S-100 2.0%, sodium sulfite 0.5%, polyvidone 5%, balance of anhydrous grape
Sugar.
The preparation method of the left-handed florfenicol solid dispersion of the compound recipe, concretely comprises the following steps：By the dissolving of Eudragit RS 100 S-100
In the ethanol equivalent to 100 times of its weight, stirring is presented clear solution after 60 minutes, adds sodium sulfite and left-handed fluorobenzene
Buddhist nun examines, dissolving, and after shearing 30 minutes into high speed shear homogenizer, in proceeding to vacuum drying oven, temperature is maintained at 60 DEG C and extremely does
It is dry, take out, 80 mesh sieves were ground, obtain carrier core layer.Then polyvidone, lysozyme, the Cortex Fraxini of recipe quantity are put into respectively
B prime and anhydrous glucose, are pelletized after mix homogeneously with appropriate purified water, and 60 DEG C of dryings, granulate obtains final product graininess compound recipe left-handed
Florfenicol solid dispersion；Wherein purified water accounts for the 5% of the left-handed florfenicol solid dispersion of graininess compound recipe.
The present invention is further described or illustrated by the following examples, but is not intended to limit the invention.
Dissolution Rate Testing, is tested using the sample of embodiment 2.
Dissolving-out method：Basket method（Annex page 114 first method of Chinese veterinary pharmacopoeia 2010 edition）；
Leaching condition：Dissolution medium is 0.1mol/L hydrochloric acid solution 900ml, and rotating speed is 50 revs/min；
Sample time：Sampled respectively at the 5th, 10,20,30,40,60,90 and 120 minutes；
Detection method：Ultraviolet visible spectrophotometry（Appendix 26 page of Chinese veterinary pharmacopoeia 2010 edition）, at 345nm wavelength
Mensuration absorbance；
Detecting instrument：Spectrophotometry instrument, model：752N types
As a result see the table below 1：
The dissolution test result of table 1
Even from Dissolution experiments as can be seen that stirring 120 minutes in 0.1mol/L hydrochloric acid solutions, dissolution only has
34.8%, meet the requirement of release 10%～50% in stomach.
Pig farm palatability experiment
The applicant carries out palatability examination on certain pig farm to the left-handed florfenicol solid dispersion of compound recipe described in above-described embodiment 2
Test.0.2kg this product is added in 20kg pig feeds and is referred to as plus spice, and another 20kg pig feeds are not added with this product and are referred to as being not added with spice.Choose
Pig be pig in 60 ages in days and 80 ages in days.60 age in days, 12 pigs on the first hurdle and the second hurdle, respectively feeding plus spice and not dosing
Material；80 age in days, 12 pigs on third column and the 4th hurdle equally operate.The material on four hurdles is eaten up more than in 5 hours, illustrates this
Product do not affect on the palatability of the pig feed of different days.
Effect judges
Test therapeutic effect observation 1. of 1 embodiment 3 to mycoplasmal pneumonia of swine and select Experimental agents：Described in the embodiment of the present invention 3
The left-handed florfenicol solid dispersion of compound recipe.2. animal subject：Certain pig farm of Hubei, through the clinical symptoms consultation of doctors, laboratory diagnosises
Make a definite diagnosis the sick pig colony that mycoplasmal pneumonia of swine occurs etc. means, clinical symptoms performance is obvious：Cough, rhinorrhea, loss of appetite
Deng laboratory diagnosiss are mycoplasma pneumonia.
（1）Blank group：Any process is not carried out；（2）Experimental group：Disperseed using solid described in the mixed feeding embodiment of the present invention 3
Agent, 300g/ ton feedstuffs, is used in conjunction 5 days.
（3）Florfenicol matched group：The 10% left-handed florfenicol powder produced using mixed feeding Hubei animal pharmaceutical factory,
300g/ ton feedstuffs, are used in conjunction 5 days
（4）Lysozyme control group：Lysozyme solid dispersion is made by oneself using mixed feeding（Lysozyme 1.0%, aesculetin 1.0%, especially
Strange S-100 2.0%, sodium sulfite 0.5%, polyvidone 5%, balance of anhydrous glucose）, 500g/ ton feedstuffs are used in conjunction 5 days.
The clinical sign of observation and recording laboratory animal, judges therapeutic effect in seven days.4. index of assessment of curative effect cure rate：Clinical condition
Shape disappears, and spirit, appetite, body temperature, breathing etc. recover normal, and category is cured, and cures number according to each group animal and calculates cure rate.
Effective percentage：The animal and symptom cured Jing after medication treatment has obvious alleviator, is judged to effectively.It is invalid
Rate：Jing medication treatment after clinical symptoms do not disappear, the state of an illness do not take a turn for the better and treat during because primary disease death be accordingly to be regarded as it is invalid,
Statistics invalid number, calculates inefficiency.
5. result see the table below 1.Therapeutic effect of the embodiment of the present invention 3 of table 1 to mycoplasmal pneumonia of swine
As seen from the above table, the embodiment of the present invention 3 is all remarkably higher than fluorobenzene to the treatment cure rate and effective percentage of mycoplasmal pneumonia of swine
Buddhist nun examines matched group and lysozyme control group and blank control group, and inefficiency is substantially less than other three groups.As a result show, the present invention
Can effectively treatment mycoplasmal pneumonia of swine.And it is observed that after the pig treatment of enforcement group, clinical symptom disappearance, appetite and spiritual shape
State etc. is significantly better than that florfenicol matched group and lysozyme control group.
Above test result indicate that, left-handed florfenicol and lysozyme, the compatibility application of aesculetin are remarkably improved dynamic
The cure rate of thing disease, good palatability.
Claims (2)
1. the left-handed florfenicol solid dispersion of a kind of compound recipe, it is characterised in that component and correspondence percentage by weight are：Left-handed fluorine
Benzene Buddhist nun examines 5～20%, lysozyme 0.5～1%, aesculetin 0.5～1%, Eudragit RS 100 S-100 1.0～2.0%, sodium sulfite
0.2～0.5%, polyvidone 2～5%, balance of anhydrous glucose.
2. the preparation method of the left-handed florfenicol solid dispersion of compound recipe is planted according to claim 1, it is characterised in that tool
Body step is as described below：
（ 1）Full dose Eudragit RS 100 S-100 dissolves in ethanol, and clear solution is presented after stirring 30-60 minutes；
（ 2）Sodium sulfite and left-handed florfenicol, dissolving is added to shear 30 minutes into high speed shear homogenizer；
（ 3）Proceed to again in vacuum drying oven, temperature is maintained at 60 DEG C to being dried, and takes out, and grinds 80 mesh sieves, obtains carrier
Core layer；
（ 4）Then polyvidone, lysozyme, aesculetin and the anhydrous glucose of recipe quantity are put into respectively, use suitable after mix homogeneously
Amount pure water granulation；
（ 5）60 DEG C of dryings, granulate obtains final product the left-handed florfenicol solid dispersion of compound recipe.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101874774A (en) * | 2009-04-29 | 2010-11-03 | 天津瑞普生物技术股份有限公司 | Suspension composition containing lysozyme and florfenicol and preparation method thereof |
| CN101934070A (en) * | 2009-07-02 | 2011-01-05 | 天津瑞普生物技术股份有限公司 | Veterinary antibacterial drug composition containing lysozyme and oligosaccharide and application thereof |
| CN103536536A (en) * | 2013-10-31 | 2014-01-29 | 成都乾坤动物药业有限公司 | Wettability solid dispersing powder of florfenicol composition and preparation method thereof |
-
2017
- 2017-01-02 CN CN201710000370.9A patent/CN106581655A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101874774A (en) * | 2009-04-29 | 2010-11-03 | 天津瑞普生物技术股份有限公司 | Suspension composition containing lysozyme and florfenicol and preparation method thereof |
| CN101934070A (en) * | 2009-07-02 | 2011-01-05 | 天津瑞普生物技术股份有限公司 | Veterinary antibacterial drug composition containing lysozyme and oligosaccharide and application thereof |
| CN103536536A (en) * | 2013-10-31 | 2014-01-29 | 成都乾坤动物药业有限公司 | Wettability solid dispersing powder of florfenicol composition and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 李范珠: "《药剂学第1版》", 28 February 2011, 中国中医药出版社 * |
| 梁承远等: "秦皮乙素及其衍生物的合成与药理学研究进展", 《陕西科技大学学报》 * |
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Application publication date: 20170426 |