CN1065752C - Sanzhufuzheng anticancer oral liquor and preparation method thereof - Google Patents
Sanzhufuzheng anticancer oral liquor and preparation method thereof Download PDFInfo
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- CN1065752C CN1065752C CN 95112116 CN95112116A CN1065752C CN 1065752 C CN1065752 C CN 1065752C CN 95112116 CN95112116 CN 95112116 CN 95112116 A CN95112116 A CN 95112116A CN 1065752 C CN1065752 C CN 1065752C
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Abstract
The present invention relates to 'Sanzhufuzheng' anti-cancer oral liquid and a preparation method thereof. The 'Sanzhufuzheng' anti-cancer oral liquid comprises Sanzhu bacterium base liquid; the present invention is characterized in that Chinese herbal medicines of astragalus root, prepared rhizome of rehmannia, pilose asiabell root, lucid ganoderma, linearstripe rabdosia herb, scutellaria, loquat leaf, reed rhizome, windpipe trachea, donkey-hide gelatin, toad's skin, stiff silkorm, snail, scorpion, centipede and gecko are added. The present invention is produced by grafting through a bionic technique according to microecology, nutriology and Chinese medicine. The present invention has the functions of supporting healthy energy, removing toxin, resolving masses, resolving phlegm, alleviating pain, etc., and is used for auxiliary treating cancers; the present invention can improve patient immunity and match with chemotherapy and radiotherapy in order to enhance the efficiency and remove toxin, and the efficiency of anticancer treatment is performed.
Description
The present invention relates to a kind of three strains and compose new recovery oral liquid and preparation method thereof, belong to the ecological agent technical field.
Cancer is a kind of commonly encountered diseases of serious threat human health.Chemotherapy and radiotherapy are current anticancer therapy ways commonly used, but both all exist human body there is very big toxic and side effects, especially seriously reduce immune function of human body, make often therefore therapy discontinued and sb.'s illness took a turn for the worse of patient, do not reach the purpose of anticancer therapeutic.
The objective of the invention is at the problems referred to above.Provide a kind of, and carry out a kind of ecological agent of grafting, production and preparation method thereof with bionic technology according to microecology threpsology and Chinese medicine and pharmacy.
The present invention is achieved in that the present invention comprises three strain bacterium basal liquids, and its composition is that Semen Glycines and Semen sojae atricolor plumule immersion 25%, beef digest soup 2.5%, yeast extract 1.3%, sucrose 1.3%, glucose 1.3%, magnesium sulfate 0.05%, sodium chloride 0.03%; Zymocyte has bacillus bifidus, lactobacillus acidophilus, DL bacterium.
The invention is characterized in to have added the Chinese herbal medicine composition that each composition and weight ratio are Radix Astragali 0.75-1.91, Radix Rehmanniae Preparata 0.5-1.25, Radix Codonopsis 0.83-2.16, Ganoderma 0.63-1.88, Herba Rabdosiae Lophanthoidis 0.53-1.50, Radix Scutellariae 0.42-1.25, Folium Eriobotryae 0.38-1.67, Rhizoma Phragmitis 0.42-1.42, Rhizoma Paridis 0.67-1.33, Colla Corii Asini 0.70-1.40, Cutis Bufonis 0.60-1.20, Bombyx Batryticatus 0.25-1.87, Limax 0.66-3.33, Scorpio 0.75-2.50, Scolopendra 0.5-3.75, Gekko Swinhonis 0.63-3.50.
Preparation technology of the present invention is:
(1) preparation of Chinese medicine extraction liquid: with the Radix Astragali, Radix Rehmanniae Preparata, Radix Codonopsis, Ganoderma, Herba Rabdosiae Lophanthoidis, Radix Scutellariae, Folium Eriobotryae, Rhizoma Phragmitis, Rhizoma Paridis, get recipe quantity, add decocting three times; Add for the first time 8 times of water gagings and decocted 1.5 hours, add 6 times of water gagings for the second time, decocted 1 hour, add 6 times of water gagings for the third time, decoct half an hour, merge three times medicinal liquid, cool off, filter, filtrate concentrates, and is standby.
(2) Cutis Bufonis, Bombyx Batryticatus, Limax, Scorpio, Scolopendra, Gekko Swinhonis are got recipe quantity and added 5 times of water, soaked 2 hours, then pulverize, and add water to 6 times of amounts, decocted 1.5 hours, and added 5 times of water gagings for the second time, decocted 1 hour, merge medicinal liquid, cold filtration, filtrate adds Colla Corii Asini, and heating makes dissolving, and be concentrated into 2.5 times of animal dose, standby.
(3) get three strain bacterium basis stock solution portion, each 1 part of (1), (2), Chinese medicine extraction liquid, mixing, heat sterilization are cooled to 40 ℃, plant three strain zymocyte, are incubated 39 ± 1 ℃, ferment after 20 hours, and fill gets final product under aseptic condition.
The major function of this product for strengthening the body resistance, detoxicating and resolving stagnation of pathogens, the pain relieving etc. of reducing phlegm, is used for auxiliary for treating cancer, improves patient's immunity, and combined with chemotherapy and radiotherapy reach the effect of potentiation and attenuation, the function of performance anticancer therapy.
Toxicity of the present invention and pharmacodynamic experiment result, mouse gavaging this product can not surveyed LD
50Value, maximum tolerated dose has reached 127g/kg.Long term toxicity test, 51 times of rats gavaged adult dosages, 60 days, none death of animal.Do not find rat outward appearance body weight, hemogram, hepatic and renal function and 11 kinds of internal organs (heart, liver, spleen, lung, kidney, hypophysis cerebri, thyroid, stomach, uterus, ovary or testis) check pathological section.Have unusual.Show that this oral liquid is safe in utilization.
Pharmacodynamic experiment of the present invention shows, can obviously suppress S
180Solid tumor (tumour inhibiting rate 65.85%) and prolongation ehrlich carcinoma survival time of mice (rate elongation 52%), and be good dose-effect relationship.The tumor-bearing mice monolithic with cyclophosphamide and
60Co radiotherapy person with add this product person relatively, the latter obviously prolongs survival time of mice, reduces the former infringement to hemogram and hepatic and renal function, and leukocyte increasing and hematochrome.Tumor-bearing mice is also had its macrophage function of raising, strengthen effects such as humoral immunization and increase lymhocyte transformation rate, prove that this product has the function that improves immunity, combined with chemotherapy and radiotherapy have good increase attenuation effect.
The embodiment of the invention:
1. write out a prescription:
Radix Astragali 16g, Radix Rehmanniae Preparata 12g, Radix Codonopsis 16g, Ganoderma 12g, Herba Rabdosiae Lophanthoidis 25g, Radix Scutellariae 8g, Folium Eriobotryae 10g, Rhizoma Phragmitis 12g, Rhizoma Paridis 9g, Colla Corii Asini 20g, Cutis Bufonis 15g, Bombyx Batryticatus 8g, Limax 7g, Scorpio 5g, Scolopendra 6g, Gekko Swinhonis 4g.
Three strain bacterium basal liquid 420ml.
2. by the method for the invention preparation.
Claims (2)
1. produce the method for right supporting anticancer oral liquid, be characterised in that and in the mixture of the Chinese medicine extract of distinguishing pre-preparation, add three strain bacterium basal liquids, in 39+1 ℃ temperature bottom fermentation 20 hours, wherein said three strain bacterium were bacillus bifidus, lactobacillus acidophilus and DL bacterium.
2. according to the process of claim 1 wherein that said medicinal herb components and weight ratio thereof are the Radix Astragali 0.75～1.91, Radix Rehmanniae Preparata 0.50～1.25, Radix Codonopsis 0.83～2.16, Ganoderma 0.63～1.88, Herba Rabdosiae Lophanthoidis 0.53～1.50, Radix Scutellariae 0.42～1.25, Folium Eriobotryae 0.38～1.67, Rhizoma Phragmitis 0.42～1.42, Paris polyphylla 0.67～1.33, Colla Corii Asini 0.70～1.40, Cutis Bufonis 0.60～1.20, Bombyx Batryticatus 0.25～1.87, Limax 0.66～3.33, Scorpio 0.75～2.50, Scolopendra 0.50～3.75, Gekko Swinhonis 0.63～3.50.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95112116 CN1065752C (en) | 1995-09-01 | 1995-09-01 | Sanzhufuzheng anticancer oral liquor and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95112116 CN1065752C (en) | 1995-09-01 | 1995-09-01 | Sanzhufuzheng anticancer oral liquor and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1144114A CN1144114A (en) | 1997-03-05 |
| CN1065752C true CN1065752C (en) | 2001-05-16 |
Family
ID=5079332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 95112116 Expired - Lifetime CN1065752C (en) | 1995-09-01 | 1995-09-01 | Sanzhufuzheng anticancer oral liquor and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1065752C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1067579C (en) * | 1998-06-01 | 2001-06-27 | 张继宏 | Medicine for curing tumor and its preparation method |
| CN1089250C (en) * | 1998-11-27 | 2002-08-21 | 杨延珍 | Anticancer oral liquid contg. lipolytic enzyme |
| CN1273839A (en) * | 2000-04-26 | 2000-11-22 | 济南三株药业有限公司 | Transfer and modification of intestinalprobiotics fermentation culture medium to natural medicine |
| CN103417620B (en) * | 2013-07-09 | 2015-02-11 | 赵晨阳 | Application of serrate rabdosia herb extract serving as STAT3 signal specific inhibiter in preparation of anti-tumor drug |
| CN106109626B (en) * | 2016-08-10 | 2019-12-06 | 四川省中医药科学院 | Pharmaceutical composition with anti-tumor effect and preparation method and application thereof |
-
1995
- 1995-09-01 CN CN 95112116 patent/CN1065752C/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| CN1144114A (en) | 1997-03-05 |
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Owner name: JINAN SANZHU FUER PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: WU BINGXIN Effective date: 20130705 |
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Free format text: CORRECT: ADDRESS; FROM: 250100 JINAN, SHANDONG PROVINCE TO: 250001 JINAN, SHANDONG PROVINCE |
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Effective date of registration: 20130705 Address after: Jiyang County, Ji'nan City, Shandong province 250001 Jibei Development Zone Industrial Park Sun Geng prosperous Street No. 2 Patentee after: Three strains of Ji'nan Pharmaceutical Co., Ltd. Address before: 250100 Ji'nan Shandong three Pharmaceutical Co., Ltd. 77 Ji'nan North Road, Zhejiang Province Patentee before: Wu Bingxin |
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