CN106561840A - Formula milk powder for relieving maternal depression and preparation method thereof - Google Patents
Formula milk powder for relieving maternal depression and preparation method thereof Download PDFInfo
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- CN106561840A CN106561840A CN201611005823.9A CN201611005823A CN106561840A CN 106561840 A CN106561840 A CN 106561840A CN 201611005823 A CN201611005823 A CN 201611005823A CN 106561840 A CN106561840 A CN 106561840A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C21/00—Whey; Whey preparations
- A23C21/06—Mixtures of whey with milk products or milk components
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C21/00—Whey; Whey preparations
- A23C21/04—Whey; Whey preparations containing non-milk components as source of fats or proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C21/00—Whey; Whey preparations
- A23C21/08—Whey; Whey preparations containing other organic additives, e.g. vegetable or animal products
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C21/00—Whey; Whey preparations
- A23C21/10—Whey; Whey preparations containing inorganic additives
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Abstract
The invention provides energy structure formula milk powder for relieving depression of postpartum lactating women and a preparation method thereof. The formula milk powder, which is designed for postpartum lactating women, not only meets the need of the population for comprehensive nutrition in the postpartum recovery period, but also largely relieves postpartum depression of the population and sleep problems caused thereby. A compound additive prepared from pumpkin, Chinese chestnut, peanut shells and the like is added to the formula milk powder, which can significantly improve the depression status of postpartum women and sleep problems caused thereby. By adding the compound additive, the dispersity of the formula milk powder is improved, milk powder agglomeration is prevented, and the stability is improved.
Description
Technical field
The present invention relates to a kind of prescription emulsifiable powder and preparation method thereof, more particularly to a kind of to alleviate the depressed prescription emulsifiable powder of puerpera
And preparation method thereof.
Background technology
Postpartum depression is type most commonly seen in women mental disorder, after being women production, due to gonadal hormone, society
A series of changes such as body, emotion, the psychology that meeting role and mental change are brought.Typical postpartum depression is 6 weeks puerperal
Interior generation is sustainable in whole puerperal, having or even before continuing to child to go to school.The sickness rate of postpartum depression 15%～
30%.
At present the ratio of China's postpartum breastfeeding Mrs's phase breast feeding is improved year by year, at the same time there is the food in one's mouth of postpartum depression
Newborn Mrs phase is also very more, and this will affect the physical and mental health of lactogenic and puerpera.The formula of traditional milk powder is mostly using milk or cattle
Milk product, addition vitamin, mineral is spray-dried or dry mixing process is prepared from, and does not account for energy-structure formula
Importance, more do not account for the depressed and sleeping problems of postpartum breastfeeding Mrs's phase generally existing.
The content of the invention
It is an object of the invention to provide it is a kind of alleviate the depressed energy-structure prescription emulsifiable powder of postpartum breastfeeding Mrs phase and its
Preparation method, for postpartum breastfeeding Mrs phase design, not only meets the demand of crowd's postpartum recovery phase to full nutrition, also very
Postpartum depression that the crowd is present and thus caused sleeping problems are alleviated in big degree.
The purpose of the present invention is achieved by the following technical solution：
It is a kind of to alleviate the depressed prescription emulsifiable powder of puerpera, it is characterised in that：Including the raw material of following weight proportioning：Defatted milk powder
20-30 parts, whole milk powder 15-20 parts, desalted whey powder 10-20 parts, plant fat powder 10-25 part, concentrated whey protein powder 1-5
Part, Lactose 5-10 part, oligofructose 5-10 parts, oligomeric galactose 5-10 parts, DHA 1.0-1.5 parts, choline 0.1-0.5 parts, L-
Carnitine 0.01-0.05 parts, taurine 0.1-0.5 parts, composite mineral matter 0.1-0.5 parts, compound vitamin 0.1-0.5 parts；
The composite mineral matter includes following components in parts by weight：Ferric phrophosphate 0.05-0.1 parts, zinc gluconate 0.01-
0.05 part, Calcium Carbonate 0.5-1.0 part, magnesium oxide 0.1-0.3 parts, potassium chloride 0.2-0.8 parts, sodium selenite 0.002-0.008 parts；
The compound vitamin includes following components in parts by weight：Vitamin A 1500-2000IU, vitamin D3 200-
500IU, vitamin C 100-200mg, vitamin K 100-150 μ g, vitamin B1500-1000 μ g, vitamin B2 500-
1000 μ g, vitamin B6300-600 μ g, pantothenic acid 1000-1500 μ g, Folic Acid 100-200 μ g；
It is a kind of to alleviate the depressed prescription emulsifiable powder of puerpera, it is characterised in that：Preparation method is：
(1) by oligomeric galactose, DHA, choline, VBT, taurine, composite mineral matter, compound vitamin mix homogeneously,
Obtain compound A；
(2) compound A is added and is uniformly mixed in carrier by extracting degreasing milk powder and plant fat powder as carrier, is obtained
Compound B；
(3) by whole milk powder, desalted whey powder, Lactose, oligofructose and concentrated whey protein powder mixing and stirring, obtain
Compound C；
(4) compound B and compound C are mixed, stir product of the present invention.
The desalted whey powder is desalted whey powder commonly used in the art, and general ash is below 1.5%；
The plant fat powder is plant fat powder commonly used in the art, and with good water solublity, breast more dissipates more
Property；
The concentrated whey protein powder is concentrated whey protein powder commonly used in the art, and its protein content is generally
34-82%；
Oligofructose is a kind of bifidus factor for improving function of intestinal canal, can be effectively improved diabeticss intestinal health
Level.After intake oligofructose, the fluctuation of human body level will not be caused, be the good sweet taste of diabetes patients
Agent.Additionally, oligofructose may additionally facilitate the cell of bacillus bifiduss, cell wall constituent and mucilage secretion propagation, therefore with carrying
Effect of high immunity of organisms.
Oligomeric galactose sweet taste is purer, calorific value relatively low (7.1J/g), and sugariness is the 20%～40% of sucrose, moisture retention
It is extremely strong.There is higher heat stability in the case where pH is neutrallty condition, heat at heating 1h or 120 DEG C at 100 DEG C after 30min, it is oligomeric
Galactose is without any decomposition.
DHA, docosahexenoic acid is commonly called as NAOHUANGJIN, is a kind of to the very important unsaturated fatty acid of human body, belongs to
Important member in omega-3 unsaturated fatty acid family.DHA is nervous system cell growth and a kind of main component for maintaining, and is
The important composition composition of brain and retina, content is up to 20% in human brain cortex, institute's accounting in eye retina
Example is maximum, accounts for 50%；
The present invention can also add Compound Supplement 0.1-0.5 parts in formula, and the Compound Supplement is by peanut skin, south
Made by melon, Semen Castaneae, stachyose etc..Other components compatibility in the Compound Supplement and prescription emulsifiable powder, can further improve product
The appearance depression status of women and thus caused sleeping problems afterwards.The addition of Compound Supplement can also improve inventive formulation breast
The dispersibility of powder, prevents milk powder from luming, and improves its stability.
Compound Supplement is added in step (1), by its with oligomeric galactose, it is DHA, choline, VBT, taurine, compound
Mineral, compound vitamin are mixed.
The Compound Supplement is made up of the raw material of following weight proportioning：Guar gum 1-3 parts, peanut skin 100-150 parts, shell
Polysaccharide 10-20 parts, stachyose 15-20 parts, Semen Castaneae 50-80 parts, threonine 1-5 parts, leucine 3-8 parts, beta-carotene 5-10
Part, Fructus Cucurbitae moschatae 20-40 parts；
The preparation method of the Compound Supplement is：
(1) dry peanut skin is taken, the mass fraction with drying peanut tare weight amount 3-5 times is the sodium chloride solution of 1-6%
Immersion 20-30h, filters, and peanut skin is rinsed 3-5 time again with water, adds shitosan, stachyose, adds drying peanut tare weight amount
8-10 times of isopropanol is extracted 3 times in 50-60 DEG C of reduced-pressure backflow, each 1h, united extraction liquid, and extracting solution stands 20- at 0-4 DEG C
24h, filters, and extract a is obtained after filter residue and drying；
(2) Semen Castaneae stir-fries 10-20min at 100-120 DEG C, is then comminuted into coarse powder, and coarse powder is mixed with threonine, leucine
Close, add the ethanol of coarse powder weight 5-10 times, 40-50 DEG C of reduced-pressure backflow is extracted 3 times, and each 1h, united extraction liquid is removed molten
Agent, obtains extract b；
(3) stripping and slicing after Fructus Cucurbitae moschatae remove seed, the volume fraction with Fructus Cucurbitae moschatae weight 3-6 times is the ethanol solution of 10-20% in 60-70
DEG C dipping 10-16h, filter, extract c is obtained after filtrate concentrate drying；
(4) guar gum, beta-carotene, extract a, extract b, extract c are mixed, is obtained final product.
The present invention is food stage using raw material, is commercially available prod.
With prior art and generic product ratio, the present invention is with advantages below：
Inventive formulation milk powder is directed to the nutritional need of Mrs puerperal, by protein energy supply 13-15%, fatty energy supply 20-
30% and the energy-structure proportioning of carbohydrate energy supply 55-60%, reasonable mixture ratio, it is more suitable for puerpera and eats.
Inventive formulation milk powder can alleviate postpartum depression, extend the length of one's sleep, improve sleep quality, can also improve milk powder
Dispersibility, improves its stability.
Specific embodiment
Embodiment 1：It is a kind of to alleviate the depressed prescription emulsifiable powder of puerpera, it is characterised in that：Including the raw material of following weight proportioning：
25 parts of defatted milk powder, 18 parts of whole milk powder, 15 parts of desalted whey powder, 20 parts of plant fat powder, 2 parts of concentrated whey protein powder, breast
Sugar 8 parts, 6 parts of oligofructose, 7 parts of oligomeric galactose, 1.3 parts of DHA, 0.4 part of choline, 0.02 part of VBT, 0.4 part of taurine,
0.2 part of composite mineral matter, 0.3 part of compound vitamin；
The composite mineral matter includes following components in parts by weight：0.09 part of ferric phrophosphate, 0.04 part of zinc gluconate, carbon
0.6 part of sour calcium, 0.2 part of magnesium oxide, 0.5 part of potassium chloride, 0.006 part of sodium selenite；
The compound vitamin includes following components in parts by weight：Vitamin A 1800IU, vitamin D3300IU, dimension life
Plain C 150mg, the μ g of vitamin K 130 and vitamin B1900 μ g, vitamin B2800 μ g, vitamin B6400 μ g, pantothenic acid 1200
μ g, the μ g of Folic Acid 150；
It is a kind of to alleviate the depressed prescription emulsifiable powder of puerpera, it is characterised in that：Preparation method is：
(1) by oligomeric galactose, DHA, choline, VBT, taurine, composite mineral matter, compound vitamin mix homogeneously,
Obtain compound A；
(2) compound A is added and is uniformly mixed in carrier by extracting degreasing milk powder and plant fat powder as carrier, is obtained
Compound B；
(3) by whole milk powder, desalted whey powder, Lactose, oligofructose and concentrated whey protein powder mixing and stirring, obtain
Compound C；
(4) compound B and compound C are mixed, stir product of the present invention.
Embodiment 2：It is a kind of to alleviate the depressed prescription emulsifiable powder of puerpera, it is characterised in that：Including the raw material of following weight proportioning：
25 parts of defatted milk powder, 18 parts of whole milk powder, 15 parts of desalted whey powder, 20 parts of plant fat powder, 2 parts of concentrated whey protein powder, breast
Sugar 8 parts, 6 parts of oligofructose, 7 parts of oligomeric galactose, 1.3 parts of DHA, 0.4 part of choline, 0.02 part of VBT, 0.4 part of taurine,
0.2 part of composite mineral matter, 0.3 part of compound vitamin, 0.3 part of Compound Supplement；
The composite mineral matter includes following components in parts by weight：0.09 part of ferric phrophosphate, 0.04 part of zinc gluconate, carbon
0.6 part of sour calcium, 0.2 part of magnesium oxide, 0.5 part of potassium chloride, 0.006 part of sodium selenite；
The compound vitamin includes following components in parts by weight：Vitamin A 1800IU, vitamin D3300IU, dimension life
Plain C 150mg, the μ g of vitamin K 130 and vitamin B1900 μ g, vitamin B2800 μ g, vitamin B6400 μ g, pantothenic acid 1200
μ g, the μ g of Folic Acid 150；
The Compound Supplement is made up of the raw material of following weight proportioning：2 parts of guar gum, 120 parts of peanut skin, shitosan 15
Part, 18 parts of stachyose, 60 parts of Semen Castaneae, 3 parts of threonine, 6 parts of leucine, 8 parts of beta-carotene, 30 parts of Fructus Cucurbitae moschatae；
The preparation method of the Compound Supplement is：
(1) dry peanut skin is taken, with the sodium chloride solution immersion that 4 times of mass fraction of drying peanut tare weight amount is 3%
25h, filters, and peanut skin is rinsed 5 times again with water, adds shitosan, stachyose, adds the isopropyl of 9 times of drying peanut tare weight amount
Alcohol is extracted 3 times in 55 DEG C of reduced-pressure backflows, each 1h, united extraction liquid, and extracting solution stands 22h at 2 DEG C, is filtered, after filter residue and drying
Obtain extract a；
(2) Semen Castaneae is then comminuted into coarse powder in 110 DEG C of 15min that stir-fry, and coarse powder is mixed with threonine, leucine, then adds
Enter the ethanol of 8 times of coarse powder weight, 45 DEG C of reduced-pressure backflows are extracted 3 times, and each 1h, united extraction liquid removes solvent, obtains extract
b；
(3) stripping and slicing after Fructus Cucurbitae moschatae remove seed, with the ethanol solution that 5 times of volume fraction of Fructus Cucurbitae moschatae weight is 15% in 65 DEG C of dippings
14h, filters, and extract c is obtained after filtrate concentrate drying；
(4) guar gum, beta-carotene, extract a, extract b, extract c are mixed, is obtained final product.
It is a kind of to alleviate the depressed prescription emulsifiable powder of puerpera, it is characterised in that：Preparation method is：
(1) by oligomeric galactose, DHA, choline, VBT, taurine, composite mineral matter, compound vitamin, compound addition
Thing mix homogeneously, obtains compound A；
(2) compound A is added and is uniformly mixed in carrier by extracting degreasing milk powder and plant fat powder as carrier, is obtained
Compound B；
(3) by whole milk powder, desalted whey powder, Lactose, oligofructose and concentrated whey protein powder mixing and stirring, obtain
Compound C；
(4) compound B and compound C are mixed, stir product of the present invention.
Embodiment 3：It is a kind of to alleviate the depressed prescription emulsifiable powder of puerpera, it is characterised in that：Including the raw material of following weight proportioning：
20 parts of defatted milk powder, 15 parts of whole milk powder, 10 parts of desalted whey powder, 10 parts of plant fat powder, 1 part of concentrated whey protein powder, breast
Sugar 5 parts, 5 parts of oligofructose, 5 parts of oligomeric galactose, 1.0 parts of DHA, 0.1 part of choline, 0.01 part of VBT, 0.1 part of taurine,
0.1 part of composite mineral matter, 0.1 part of compound vitamin, 0.1 part of Compound Supplement；
The composite mineral matter includes following components in parts by weight：0.1 part of ferric phrophosphate, 0.05 part of zinc gluconate, carbon
1.0 parts of sour calcium, 0.3 part of magnesium oxide, 0.8 part of potassium chloride, 0.008 part of sodium selenite；
The compound vitamin includes following components in parts by weight：Vitamin A 2000IU, vitamin D3500IU, dimension life
Plain C 200mg, the μ g of vitamin K 150 and vitamin B11000 μ g, vitamin B21000 μ g, vitamin B6600 μ g, pantothenic acid
1500 μ g, the μ g of Folic Acid 200；
The Compound Supplement is made up of the raw material of following weight proportioning：1 part of guar gum, 100 parts of peanut skin, shitosan 10
Part, 15 parts of stachyose, 50 parts of Semen Castaneae, 1 part of threonine, 3 parts of leucine, 5 parts of beta-carotene, 20 parts of Fructus Cucurbitae moschatae；
The preparation method of the Compound Supplement is：
(1) dry peanut skin is taken, with the sodium chloride solution immersion that 5 times of mass fraction of drying peanut tare weight amount is 6%
30h, filters, and peanut skin is rinsed 5 times again with water, adds shitosan, stachyose, adds the isopropyl of 10 times of drying peanut tare weight amount
Alcohol is extracted 3 times in 60 DEG C of reduced-pressure backflows, each 1h, united extraction liquid, and extracting solution stands 24h at 4 DEG C, is filtered, after filter residue and drying
Obtain extract a；
(2) Semen Castaneae is then comminuted into coarse powder in 120 DEG C of 20min that stir-fry, and coarse powder is mixed with threonine, leucine, then adds
Enter the ethanol of 10 times of coarse powder weight, 50 DEG C of reduced-pressure backflows are extracted 3 times, and each 1h, united extraction liquid removes solvent, is extracted
Thing b；
(3) stripping and slicing after Fructus Cucurbitae moschatae remove seed, with the ethanol solution that 6 times of volume fraction of Fructus Cucurbitae moschatae weight is 20% in 70 DEG C of dippings
16h, filters, and extract c is obtained after filtrate concentrate drying；
(4) guar gum, beta-carotene, extract a, extract b, extract c are mixed, is obtained final product.
The preparation method of prescription emulsifiable powder is with embodiment 2.
Embodiment 4：It is a kind of to alleviate the depressed prescription emulsifiable powder of puerpera, it is characterised in that：Including the raw material of following weight proportioning：
30 parts of defatted milk powder, 20 parts of whole milk powder, 20 parts of desalted whey powder, 25 parts of plant fat powder, 5 parts of concentrated whey protein powder, breast
10 parts of sugar, 10 parts of oligofructose, 10 parts of oligomeric galactose, 1.5 parts of DHA, 0.5 part of choline, 0.05 part of VBT, taurine 0.5
Part, 0.3 part of composite mineral matter, 0.3 part of compound vitamin, 0.5 part of Compound Supplement；
The composite mineral matter includes following components in parts by weight：0.05 part of ferric phrophosphate, 0.01 part of zinc gluconate, carbon
0.6 part of sour calcium, 0.1 part of magnesium oxide, 0.4 part of potassium chloride, 0.005 part of sodium selenite；
The compound vitamin includes following components in parts by weight：Vitamin A 2000IU, vitamin D3200IU, dimension life
Plain C 200mg, the μ g of vitamin K 150 and vitamin B1800 μ g, vitamin B21000 μ g, vitamin B6500 μ g, pantothenic acid
1500 μ g, the μ g of Folic Acid 200；
The Compound Supplement is made up of the raw material of following weight proportioning：3 parts of guar gum, 150 parts of peanut skin, shitosan 20
Part, 20 parts of stachyose, 80 parts of Semen Castaneae, 5 parts of threonine, 8 parts of leucine, 10 parts of beta-carotene, 40 parts of Fructus Cucurbitae moschatae；
The preparation method of the Compound Supplement is：
(1) dry peanut skin is taken, with the sodium chloride solution immersion that 3 times of mass fraction of drying peanut tare weight amount is 1%
20h, filters, and peanut skin is rinsed 3 times again with water, adds shitosan, stachyose, adds the isopropyl of 8 times of drying peanut tare weight amount
Alcohol is extracted 3 times in 50 DEG C of reduced-pressure backflows, each 1h, united extraction liquid, and extracting solution stands 20h at 0 DEG C, is filtered, after filter residue and drying
Obtain extract a；
(2) Semen Castaneae is then comminuted into coarse powder in 100 DEG C of 10min that stir-fry, and coarse powder is mixed with threonine, leucine, then adds
Enter the ethanol of 5 times of coarse powder weight, 40 DEG C of reduced-pressure backflows are extracted 3 times, and each 1h, united extraction liquid removes solvent, obtains extract
b；
(3) stripping and slicing after Fructus Cucurbitae moschatae remove seed, with the ethanol solution that 3 times of volume fraction of Fructus Cucurbitae moschatae weight is 10% in 60 DEG C of dippings
10h, filters, and extract c is obtained after filtrate concentrate drying；
(4) guar gum, beta-carotene, extract a, extract b, extract c are mixed, is obtained final product.
The preparation method of prescription emulsifiable powder is with embodiment 2.
Embodiment 5：It is a kind of to alleviate the depressed prescription emulsifiable powder of puerpera, it is characterised in that：It is characterized in that：With the phase of embodiment 2
Than there is following difference：
The preparation method of the Compound Supplement is：
(1) dry peanut skin is taken, with the sodium chloride solution immersion that 5 times of mass fraction of drying peanut tare weight amount is 8%
40h, filters, and peanut skin is rinsed 3 times again with water, adds shitosan, stachyose, adds the ethanol of 10 times of drying peanut tare weight amount
Extract 3 times in 65 DEG C of reduced-pressure backflows, each 1h, united extraction liquid, extracting solution stands 10h, filter, extracted after filter residue and drying
Thing a；
(2) Semen Castaneae is then comminuted into coarse powder in 130 DEG C of 30min that stir-fry, and coarse powder is mixed with threonine, leucine, then adds
Enter the isopropanol of 10 times of coarse powder weight, 60 DEG C of reduced-pressure backflows are extracted 3 times, and each 1h, united extraction liquid removes solvent, is carried
Take thing b；
(3) stripping and slicing after Fructus Cucurbitae moschatae remove seed, with the ethanol solution that 6 times of volume fraction of Fructus Cucurbitae moschatae weight is 25% in 50 DEG C of dippings
10h, filters, and extract c is obtained after filtrate concentrate drying；
(4) guar gum, beta-carotene, extract a, extract b, extract c are mixed, is obtained final product.
1. the measure of mouse tail suspension dead time：ICR male and healthies mice 60, cleaning grade, weight 18-22g is divided into
1 blank group and 5 test groups, 10 per group, animal nature circadian rhythm illumination is tested after adapting to 1 week, tests component
Other gavage gives prescription emulsifiable powder obtained in embodiment 1-5, and blank control group gives the distilled water of equivalent, and 1 time/d, continuous 15d gives
Dose is 0.6g/10g body weight.1h carries out Tail suspension test after administration in the 15th day.By single mice tail end (away from tail end
At 2cm) it is bonded on a horizontal waddy on outstanding boot top with adhesive plaster so as to into projecting state, head is middle from bottom 10cm
Mice sight line is isolated with dividing plate.Observation 6min, with the accumulative dead time of mice in 4min after camera record, each parallel observations
6 mices.
Impact of the inventive formulation milk powder of table 1 to the mouse tail suspension dead time
| Group | The motionless average time (s) of mouse tail suspension |
| Blank control group | 146.4 |
| Embodiment 1 | 135.0 |
| Embodiment 2 | 117.8 |
| Embodiment 3 | 121.5 |
| Embodiment 4 | 120.1 |
| Embodiment 5 | 129.6 |
As shown in Table 1, inventive formulation milk powder can shorten the mouse tail suspension dead time, with certain antidepressant effect.
2. sleep experiments：Male Kun Ming mice 72, body weight 18-21g, mice is randomly divided into 1 blank control group
With 5 test groups, 12 per group.5 test groups give respectively prescription emulsifiable powder 60mg/kg/d obtained in embodiment 1-5, blank right
Equivalent distilled water gavage, continuous gavage 15d are given according to group.Determining before experiment makes animal 100% fall asleep, and does not make the mistake length of one's sleep
Long pentobarbital sodium dosage ((45mg/kg).Animal last is given after medicine 1h, gives each group animal lumbar injection pentobarbital sodium
10m1/kg, with righting reflex loss as index, can observe inventive formulation milk powder extend the sleep of threshold dose pentobarbital sodium
Time.
Determine that animal 100% falls asleep before experiment, but do not make long barbital sodium dosage (260mg/kg) length of one's sleep.
After animal last dose 1h, each group animal lumbar injection barbital sodium 10m1/kg is given, with righting reflex loss as index, observation
Impact of the inventive formulation milk powder to barbital sodium Sleep latency.
Impact of the inventive formulation milk powder of table 2 to the threshold dose pentobarbital sodium length of one's sleep
| Group | The average length of one's sleep (min) |
| Blank control group | 34.9 |
| Embodiment 1 | 38.7 |
| Embodiment 2 | 46.6 |
| Embodiment 3 | 46.0 |
| Embodiment 4 | 45.8 |
| Embodiment 5 | 41.2 |
Impact of the inventive formulation milk powder of table 3 to barbital sodium Sleep latency
| Group | The average Sleep latency time (min) |
| Blank control group | 18.5 |
| Embodiment 1 | 18.1 |
| Embodiment 2 | 16.0 |
| Embodiment 3 | 16.3 |
| Embodiment 4 | 16.8 |
| Embodiment 5 | 17.5 |
From table 2 and table 3, inventive formulation milk powder is asked when can be obviously prolonged the mice sleep of pentobarbital sodium induction,
Substantially shorten mice sleep incubation period of barbital sodium induction, illustrate that inventive formulation milk powder has clear improvement the work of mice sleep
With.
3. dispersibility is determined：The each lOg of prescription emulsifiable powder of embodiment 1-5 preparation is weighed, in being respectively put into 100mL beakers, plus
Enter 65 DEG C of deionized waters of 70mL, be then stirred with same speed, record from stirring and start in cup without milk powder caking
Time (s).
The dispersibility of the inventive formulation milk powder of table 4 is investigated
| Group | Dispersibility (s) |
| Embodiment 1 | 54.9 |
| Embodiment 2 | 38.6 |
| Embodiment 3 | 42.8 |
| Embodiment 4 | 40.5 |
| Embodiment 5 | 48.3 |
From above-mentioned experiment, prescription emulsifiable powder can alleviate postpartum depression and sleep disorder, embodiment 2- obtained in embodiment 1
Prescription emulsifiable powder antidepressant effect obtained in 5 more preferably, can also improve the dispersibility of prescription emulsifiable powder, but (the Compound Supplement life of embodiment 5
Production. art is provided without technical solution of the present invention) effect is slightly worse.
Claims (5)
- It is 1. a kind of to alleviate the depressed prescription emulsifiable powder of puerpera, it is characterised in that：Including the raw material of following weight proportioning：Defatted milk powder 25 It is part, 18 parts of whole milk powder, 15 parts of desalted whey powder, 20 parts of plant fat powder, 2 parts of concentrated whey protein powder, 8 parts of Lactose, oligomeric 6 parts of Fructose, 7 parts of oligomeric galactose, 1.3 parts of DHA, 0.4 part of choline, 0.02 part of VBT, 0.4 part of taurine, composite mineral matter 0.2 part, 0.3 part of compound vitamin；The composite mineral matter includes following components in parts by weight：0.09 part of ferric phrophosphate, 0.04 part of zinc gluconate, Calcium Carbonate 0.6 part, 0.2 part of magnesium oxide, 0.5 part of potassium chloride, 0.006 part of sodium selenite；The compound vitamin includes following components in parts by weight：Vitamin A 1800IU, vitamin D3300IU, vitamin C 150mg, the μ g of vitamin K 130 and vitamin B1900 μ g, vitamin B2800 μ g, vitamin B6400 μ g, the μ g of pantothenic acid 1200, The μ g of Folic Acid 150.
- It is 2. a kind of as claimed in claim 1 to alleviate the depressed prescription emulsifiable powder of puerpera, it is characterised in that：Preparation method is：(1) by oligomeric galactose, DHA, choline, VBT, taurine, composite mineral matter, compound vitamin mix homogeneously, obtain Compound A；(2) compound A is added and is uniformly mixed in carrier by extracting degreasing milk powder and plant fat powder as carrier, must be mixed Material B；(3) by whole milk powder, desalted whey powder, Lactose, oligofructose and concentrated whey protein powder mixing and stirring, must mix Material C；(4) compound B and compound C are mixed, stir product of the present invention.
- It is 3. a kind of as claimed in claim 1 to alleviate the depressed prescription emulsifiable powder of puerpera, it is characterised in that：Also include in formula compound Additive 0.1-0.5 parts；The Compound Supplement is made up of the raw material of following weight proportioning：Guar gum 1-3 parts, peanut skin 100-150 parts, shitosan 10-20 parts, stachyose 15-20 parts, Semen Castaneae 50-80 parts, threonine 1-5 parts, leucine 3-8 parts, beta-carotene 5-10 parts, south Melon 20-40 parts；The preparation method of the Compound Supplement is：(1) dry peanut skin is taken, the mass fraction with drying peanut tare weight amount 3-5 times is the sodium chloride solution immersion of 1-6% 20-30h, filters, and peanut skin is rinsed 3-5 time again with water, adds shitosan, stachyose, adds drying peanut tare weight amount 8-10 Isopropanol again is extracted 3 times in 50-60 DEG C of reduced-pressure backflow, each 1h, united extraction liquid, and extracting solution stands 20-24h at 0-4 DEG C, Filter, extract a is obtained after filter residue and drying；(2) Semen Castaneae stir-fries 10-20min at 100-120 DEG C, is then comminuted into coarse powder, and coarse powder is mixed with threonine, leucine, The ethanol of coarse powder weight 5-10 times is added, 40-50 DEG C of reduced-pressure backflow is extracted 3 times, and each 1h, united extraction liquid removes solvent, Obtain extract b；(3) stripping and slicing after Fructus Cucurbitae moschatae remove seed, the volume fraction with Fructus Cucurbitae moschatae weight 3-6 times is the ethanol solution of 10-20% in 60-70 DEG C of leaching Stain 10-16h, filters, and extract c is obtained after filtrate concentrate drying；(4) guar gum, beta-carotene, extract a, extract b, extract c are mixed, is obtained final product.
- It is 4. a kind of as claimed in claim 1 to alleviate the depressed prescription emulsifiable powder of puerpera, it is characterised in that：Also include in formula compound 0.3 part of additive；The composite mineral matter includes following components in parts by weight：0.09 part of ferric phrophosphate, 0.04 part of zinc gluconate, Calcium Carbonate 0.6 part, 0.2 part of magnesium oxide, 0.5 part of potassium chloride, 0.006 part of sodium selenite；The compound vitamin includes following components in parts by weight：Vitamin A 1800IU, vitamin D3300IU, vitamin C 150mg, the μ g of vitamin K 130 and vitamin B1900 μ g, vitamin B2800 μ g, vitamin B6400 μ g, the μ g of pantothenic acid 1200, The μ g of Folic Acid 150；The Compound Supplement is made up of the raw material of following weight proportioning：2 parts of guar gum, 120 parts of peanut skin, 15 parts of shitosan, 18 parts of stachyose, 60 parts of Semen Castaneae, 3 parts of threonine, 6 parts of leucine, 8 parts of beta-carotene, 30 parts of Fructus Cucurbitae moschatae；The preparation method of the Compound Supplement is：(1) dry peanut skin is taken, with the sodium chloride solution that 4 times of mass fraction of drying peanut tare weight amount is 3% 25h is soaked, Filter, peanut skin is rinsed 5 times again with water, add shitosan, stachyose, the isopropanol for adding 9 times of drying peanut tare weight amount to exist 55 DEG C of reduced-pressure backflows are extracted 3 times, and each 1h, united extraction liquid, extracting solution stands 22h at 2 DEG C, are filtered, and are obtained after filter residue and drying Extract a；(2) Semen Castaneae is then comminuted into coarse powder in 110 DEG C of 15min that stir-fry, and coarse powder is mixed with threonine, leucine, adds thick The ethanol that 8 times of grain weight amount, 45 DEG C of reduced-pressure backflows are extracted 3 times, each 1h, and united extraction liquid removes solvent, obtains extract b；(3) stripping and slicing after Fructus Cucurbitae moschatae remove seed, 14h, mistake are impregnated with the ethanol solution that 5 times of volume fraction of Fructus Cucurbitae moschatae weight is 15% at 65 DEG C Filter, obtains extract c after filtrate concentrate drying；(4) guar gum, beta-carotene, extract a, extract b, extract c are mixed, is obtained final product.
- 5. a kind of depressed prescription emulsifiable powder of alleviation puerpera as described in claim 3 or 4, it is characterised in that：Preparation method is：(1) oligomeric galactose, DHA, choline, VBT, taurine, composite mineral matter, compound vitamin, Compound Supplement are mixed Close uniform, obtain compound A；(2) compound A is added and is uniformly mixed in carrier by extracting degreasing milk powder and plant fat powder as carrier, must be mixed Material B；(3) by whole milk powder, desalted whey powder, Lactose, oligofructose and concentrated whey protein powder mixing and stirring, must mix Material C；(4) compound B and compound C are mixed, stir product of the present invention.
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| CN201611005823.9A CN106561840A (en) | 2016-11-16 | 2016-11-16 | Formula milk powder for relieving maternal depression and preparation method thereof |
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| CN107348483A (en) * | 2017-07-05 | 2017-11-17 | 阎艺方 | A kind of pregnant and lying-in women's full function nutritious supplementary pharmaceutical |
| CN108403724A (en) * | 2018-04-20 | 2018-08-17 | 北京斯利安药业有限公司 | A kind of composition and preparation method thereof of adjustable mood |
| CN109156535A (en) * | 2018-11-14 | 2019-01-08 | 杭州上禾健康科技有限公司 | A kind of maternal nutritional product and its production technology |
| CN116268107A (en) * | 2023-02-24 | 2023-06-23 | 西北农林科技大学 | Formula goat milk powder with antidepressant function and preparation method thereof |
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| CN116268107A (en) * | 2023-02-24 | 2023-06-23 | 西北农林科技大学 | Formula goat milk powder with antidepressant function and preparation method thereof |
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Application publication date: 20170419 |