CN1065433C - Oily preparation and method of production thereof - Google Patents
Oily preparation and method of production thereof Download PDFInfo
- Publication number
- CN1065433C CN1065433C CN93109052A CN93109052A CN1065433C CN 1065433 C CN1065433 C CN 1065433C CN 93109052 A CN93109052 A CN 93109052A CN 93109052 A CN93109052 A CN 93109052A CN 1065433 C CN1065433 C CN 1065433C
- Authority
- CN
- China
- Prior art keywords
- oily preparation
- oil
- plumelet
- semen
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 61
- 238000000034 method Methods 0.000 title claims description 10
- 238000004519 manufacturing process Methods 0.000 title abstract description 5
- 239000000203 mixture Substances 0.000 claims abstract description 36
- 239000000843 powder Substances 0.000 claims abstract description 31
- 239000000463 material Substances 0.000 claims abstract description 30
- 238000010438 heat treatment Methods 0.000 claims abstract description 21
- 235000013339 cereals Nutrition 0.000 claims abstract description 15
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 14
- 240000007594 Oryza sativa Species 0.000 claims abstract description 13
- 210000000582 semen Anatomy 0.000 claims description 44
- 240000005979 Hordeum vulgare Species 0.000 claims description 7
- 235000007340 Hordeum vulgare Nutrition 0.000 claims description 7
- 239000002775 capsule Substances 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 6
- 235000011837 pasties Nutrition 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims 2
- 235000013402 health food Nutrition 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 abstract description 41
- 239000003963 antioxidant agent Substances 0.000 abstract description 40
- 201000010099 disease Diseases 0.000 abstract description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 15
- 235000003434 Sesamum indicum Nutrition 0.000 abstract description 12
- 239000002994 raw material Substances 0.000 abstract description 9
- 239000000126 substance Substances 0.000 abstract description 5
- 235000009566 rice Nutrition 0.000 abstract description 2
- 244000000231 Sesamum indicum Species 0.000 abstract 2
- 244000068988 Glycine max Species 0.000 abstract 1
- 235000010469 Glycine max Nutrition 0.000 abstract 1
- 241000209140 Triticum Species 0.000 abstract 1
- 235000021307 Triticum Nutrition 0.000 abstract 1
- 230000000149 penetrating effect Effects 0.000 abstract 1
- 235000006708 antioxidants Nutrition 0.000 description 39
- 239000003921 oil Substances 0.000 description 30
- 235000019198 oils Nutrition 0.000 description 30
- 230000000052 comparative effect Effects 0.000 description 18
- 210000004027 cell Anatomy 0.000 description 13
- 238000012360 testing method Methods 0.000 description 13
- 241000196324 Embryophyta Species 0.000 description 12
- 244000040738 Sesamum orientale Species 0.000 description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 10
- 239000001301 oxygen Substances 0.000 description 10
- 229910052760 oxygen Inorganic materials 0.000 description 10
- -1 lipid peroxide Chemical class 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 8
- 210000000170 cell membrane Anatomy 0.000 description 7
- RVBUGGBMJDPOST-UHFFFAOYSA-N 2-thiobarbituric acid Chemical compound O=C1CC(=O)NC(=S)N1 RVBUGGBMJDPOST-UHFFFAOYSA-N 0.000 description 6
- 244000077995 Coix lacryma jobi Species 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- 240000008042 Zea mays Species 0.000 description 4
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 4
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 4
- 235000005822 corn Nutrition 0.000 description 4
- 230000009849 deactivation Effects 0.000 description 4
- 235000015097 nutrients Nutrition 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 208000033386 Buerger disease Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 208000003351 Melanosis Diseases 0.000 description 3
- 208000003782 Raynaud disease Diseases 0.000 description 3
- 208000012322 Raynaud phenomenon Diseases 0.000 description 3
- 208000034189 Sclerosis Diseases 0.000 description 3
- 206010043540 Thromboangiitis obliterans Diseases 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 230000003064 anti-oxidating effect Effects 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- DVSZKTAMJJTWFG-UHFFFAOYSA-N docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCCC=CC=CC=CC=CC=CC=CC(O)=O DVSZKTAMJJTWFG-UHFFFAOYSA-N 0.000 description 3
- MBMBGCFOFBJSGT-KUBAVDMBSA-N docosahexaenoic acid Natural products CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 150000002333 glycines Chemical class 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000003859 lipid peroxidation Effects 0.000 description 3
- 239000012466 permeate Substances 0.000 description 3
- 208000037922 refractory disease Diseases 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000004575 stone Substances 0.000 description 3
- 201000005060 thrombophlebitis Diseases 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 description 3
- 239000008158 vegetable oil Substances 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 102000003992 Peroxidases Human genes 0.000 description 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
- 229930003270 Vitamin B Natural products 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 108040007629 peroxidase activity proteins Proteins 0.000 description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- 238000003672 processing method Methods 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 239000008159 sesame oil Substances 0.000 description 2
- 235000011803 sesame oil Nutrition 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 235000018553 tannin Nutrition 0.000 description 2
- 229920001864 tannin Polymers 0.000 description 2
- 239000001648 tannin Substances 0.000 description 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 2
- 235000019156 vitamin B Nutrition 0.000 description 2
- 239000011720 vitamin B Substances 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 240000006439 Aspergillus oryzae Species 0.000 description 1
- 235000002247 Aspergillus oryzae Nutrition 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
- 208000027932 Collagen disease Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 241000209094 Oryza Species 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 239000000589 Siderophore Substances 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 1
- 206010047115 Vasculitis Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- GLLRIXZGBQOFLM-UHFFFAOYSA-N Xanthorin Natural products C1=C(C)C=C2C(=O)C3=C(O)C(OC)=CC(O)=C3C(=O)C2=C1O GLLRIXZGBQOFLM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 201000001981 dermatomyositis Diseases 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- IYDGMDWEHDFVQI-UHFFFAOYSA-N phosphoric acid;trioxotungsten Chemical compound O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.OP(O)(O)=O IYDGMDWEHDFVQI-UHFFFAOYSA-N 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/02—Other edible oils or fats, e.g. shortenings, cooking oils characterised by the production or working-up
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B3/00—Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shape; Layered products comprising a layer having particular features of form
- B32B3/10—Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shape; Layered products comprising a layer having particular features of form characterised by a discontinuous layer, i.e. formed of separate pieces of material
- B32B3/12—Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shape; Layered products comprising a layer having particular features of form characterised by a discontinuous layer, i.e. formed of separate pieces of material characterised by a layer of regularly- arranged cells, e.g. a honeycomb structure
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/50—Soya sauce
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
- A23L7/10—Cereal-derived products
- A23L7/104—Fermentation of farinaceous cereal or cereal material; Addition of enzymes or microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
- A23L7/10—Cereal-derived products
- A23L7/152—Cereal germ products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D24/00—Producing articles with hollow walls
- B29D24/002—Producing articles with hollow walls formed with structures, e.g. cores placed between two plates or sheets, e.g. partially filled
- B29D24/005—Producing articles with hollow walls formed with structures, e.g. cores placed between two plates or sheets, e.g. partially filled the structure having joined ribs, e.g. honeycomb
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/06—Production of fats or fatty oils from raw materials by pressing
- C11B1/08—Production of fats or fatty oils from raw materials by pressing by hot pressing
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Birds (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mechanical Engineering (AREA)
- Biochemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Fats And Perfumes (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
An oily preparation and its production method where the activity of antioxidant substances as effective components are high and the penetrating ability into the inside of the cell in a disease portion is high, and its production method. The oily preparation is prepared by heating a cereal raw material comprising rice germ and/or wheat germ and soybean at a temperature not exceeding 100.degree.C; making it fine powder after koji is added to the heated material to brew it; and adding thus brewed powder to an oil mixture comprising an oil obtained from sesame heated in the same manner and an oil obtained from raw sesame, wherein a ratio of oil mixture to a total amount of the fine powder and the oil mixture is 60 to 95 % by weight.
Description
The invention relates to a kind of Oily preparation and preparation method thereof.Especially about containing as the Oily preparation that produces the material of active oxygen and lipid peroxide in the inhibition human body of effective ingredient.Hereinafter these materials are called antioxidant.
Recently, people's attention has been attracted on the antioxidant, these materials are when being used for prevention and treating various inflammation and chronic refractory disease, for example, beaevais' disease, thrombophlebitis, carrying out property system sclerosis, thromboangiitis obliterans, raynaud disease, intractable cutaneous ulcer, and cause cell tissue to destroy and the disease that causes by active oxygen that produces in the human body and lipid peroxide.
According to present inventor's research verified above-mentioned antioxidant contain low molecular weight substance, such as flavonoid class, Polyphenols, tannins, vitamin E, vitamin B
1With the analog that contains at plant, by oral as medicine or health protection food, suppress interior above-mentioned active oxygen of generation of human body and lipid peroxide and (see " Japanese association of pharmacists magazine " No.39. of December in 1987 publication on the 1st, Vol.102, the bioavailability of SOD that augments (superoxide dismutase) and natural drug ", PP.1097-1119.
Usually, as the preparation that contains such antioxidant, the anti-oxidant compositions that discloses among the Japanese unexamined patent publication number 63-79834 of nutrient for plants of having known that Japan Patent 1366268 is arranged and Niwa.
The nutrient for plants of Japan Patent 1366268 makes like this: green tea is not mixed with coarse rice powder that toasted and Semen Glycines powder; Add a small amount of Japanese fermented preparation fungus in the mixture; This then mixed-powder soaked 4 days in the mixed liquor of Oleum Sesami and Oleum Glycines, effective component extracting; Use the centrifugal separation disgorging; And oily matter is encapsulated in the capsule of gelatin or analog system.
The anti-oxidant compositions of Japanese patent application 63-79834 makes like this: plant seed or its plumule suitably heated, but can not be burned; Add microorganism subsequently, the plant material that heated is brewageed; And then be added in the vegetable oil that from the plant of suitable heating, obtains and go.At random in compositions, add vitamin C, ascorbic derivant or contain their plant.
Use a kind of antioxidant that contains, for example above-mentioned flavonoid class, Polyphenols, tannins, vitamin E, vitamin B
1Or the like seed as plant seed, comprise Oryza glutinosa, Semen Tritici aestivi, Fructus Hordei Vulgaris, Semen sojae atricolor, Semen Phaseoli, corn, hatomugi (pearl barley) Semen Pisi sativi.With Oleum sesami, Oleum Glycines, Oleum Gossypii semen, Semen Maydis oil, safflower oil, Radix Oenotherae erythrosepalae oil, Testa oryzae oil, vegetable oil, olive oil and similarly oily as vegetable oil.
Yet, because the processing method of the plant material of the nutrient for plants of Japan Patent 1366268 makes its antioxidant activity low.
The anti-oxidant compositions of the Japanese patent application 63-79834 of Niwa has been eliminated this problem, it is by make suitable the heating of plant material with far infrared radiation, and it is not burned, so just prevented owing to high temperature makes the antioxidant deactivation, thereby make raw material release and change into low-molecular-weight effective ingredient, also, so just improved the activity of antioxidant significantly through brewageing heat treated like this material to impel them and further discharge and to change into low-molecular-weight active substance.
But after there, verified according to present inventor's research, though above-mentioned antioxidant in test tube obvious suppression the generation of active oxygen and lipid peroxide, the activity of these antioxidant does not sufficiently show in human body.
We think, ill such as the inflammatory reaction or the similar because the inside of the disease cell that active oxygen and lipid peroxide cause in order to allow polyphenoils mass-energy arrive, it just must pass the cell membrane that is wrapped in cell surface.But a lot of oil ﹠ fat compositions are arranged on the human body cell film, so it has the such a kind of character that only allows oily matter pass through, so the ability that the permeates cell membranes that the low anti-oxidant compositions of above-mentioned oily matter content has enters in the cell is just low.
So the present inventor has done research repeatedly in order to improve the ability of antioxidant permeates cell membranes, also further improve simultaneously and select as the floristics of raw material and its processing method.So, having obtained the active high of a kind of antioxidant as effective ingredient, and penetrated into the also high Oily preparation of ability of ill cell the inside, this has just finished the present invention.
Purpose of the present invention just provides the preparation method of a kind of Oily preparation and it, and wherein the ability active high, that penetrate in the disease location cell as the antioxidant of effective ingredient is also big.
The preparation method of Oily preparation of the present invention comprises: be no more than heating Oryza glutinosa plumelet and/or Semen Tritici aestivi plumelet and Semen sojae atricolor under 100 ℃ the temperature; Japanese fermented preparation is added among the heat material; Brewage mixture; Then mixture is pulverized: and the mixture of the pulverizing that will obtain is added to be included in and is no more than 100 ℃ down in the oil mixture of the oil that obtains of the Semen Sesamis of heating and the oil that obtained by living Semen Sesami, and wherein the ratio of the total amount of the mixture of oil mixture and pulverizing and oil mixture is 60～95% (weight).
As the raw material that contains a lot of antioxidant, except that said Oryza glutinosa plumelet, Semen Tritici aestivi plumelet and Semen sojae atricolor, also has listed floristics in Japanese unexamined patent publication number 63-79834, Fructus Hordei Vulgaris, Semen Phaseoli, corn, hatomugi (pearl barley), Semen Pisi sativi or the like are promptly arranged, but according to present inventor's research, Oryza glutinosa plumelet, Semen Tritici aestivi plumelet and Semen sojae atricolor are best raw materials.
List under Oryza glutinosa plumelet, Semen Tritici aestivi plumelet and the Semen sojae atricolor is Testa oryzae, hatomugi (pearl barley) and Semen Tritici aestivi.So as raw material, at least a Testa oryzae, hatomugi (pearl barley) and Semen Tritici aestivi can mix with Oryza glutinosa plumelet and/or Semen Tritici aestivi plumelet.Under any circumstance, the ratio of the plumelet in the cereal materials (Oryza glutinosa plumelet and/or Semen Tritici aestivi plumelet) is preferably at least more than or equal to 1% (weight).
Antioxidant in above-mentioned cereal materials forms complicated macromolecule polyalcohol with other material, so when it does not just have activity when being such, therefore just must utilize suitable heating or similar means to cut off the macromole key, so that discharge the low-molecular-weight antioxidant.If yet heating-up temperature is too high, the low-molecular-weight antioxidant so just must be noted that this situation of consideration, is selected heating condition just by deactivation.
In order to satisfy this condition, must make cereal materials slowly heat the sufficiently long time being lower than under 100 ℃ the temperature.Describe in detail, exactly cereal materials is placed in the container of being made by ceramic material, for example in pottery or the container such as the far away red place ray that preferably can launch the 4-14 mum wavelength, heat when slowly stirring, temperature remains on about 90～96 ℃.
The kind of corn is depended in the variation of heat time heating time, thus can not indiscriminately lump together, yet between preferably about 30 minutes to 3 hours.By the way, heating means are not limited to said method, as long as the antioxidant in the cereal materials is enough to discharge with lower-molecular substance, the method for having avoided the lower-molecular substance deactivation simultaneously all is feasible.
After the above-mentioned heat treated, Japanese fermented preparation's (aspergillus oryzae) is added in the raw material brewages.The condition of brewageing is preferably in 20～36 ℃ and descended about 2～6 days.When brewageing, just be enough in about 2～3 hours with fermentation tank.Will carry out this brewageing in order further to impel to discharge and change into the low-molecular-weight antioxidant in the cereal materials, by this step of brewageing, the activity of antioxidant is significantly improved with the raw material ratio of a heat-treated.
Then, the improved grinding of brewageing is become fine powder.Can grind with general commercially available grinder.But the grinder of some kind produces high temperature during use, so just makes the antioxidant deactivation.So, can not produce pyritous grinder when preferably using those to use.For example, can use burrstone mill.
Then, by oil (after this claiming sesame paste oil) that obtains from the Semen Sesami of heating and the oil that obtains from living Semen Sesami are mixed with out miscella with a suitable ratio.And above-mentioned fine powder is added in the oil mixture, sesame paste oil is slowly to heat the sufficiently long time by living Semen Sesami being lower than under 100 ℃ the temperature, and grind the oil that obtains after pressing, but grinding the very thin solids that forms, Semen Sesami remained, so its appearance just is rendered as pasty state.This sesame paste oil contains competent low-molecular-weight antioxidant, and uses it, can obtain having the Oily preparation of high activity antioxidant.
But this sesame paste oil viscosity is very high, and the size of oil droplet is also very big, so the ability that preparation only oily with sesame paste and above-mentioned fine powder penetrates in the disease location cell is just very little.Yet when adding the Oleum sesami that is obtained by living Semen Sesami in sesame paste oil, the size of oil droplet is just little, and has also improved it and penetrate into ability in the disease location cell.
From the collected oil of living Semen Sesami is that living Semen Sesami is ground, after the squeezing, removes solids and make just commercially available common Oleum sesami.Because sesame paste oil is different with the mixing ratio of common sesame oil, also depend on add the amount of fine powder, so can not indiscriminately determine.With regard to the sesame paste of 1 part of weight oil, the common sesame oil of 1-3 weight portion preferably.
Oil mixture is such with the ratio of the fine powder that adds inward, and promptly miscella can reach 60%～95% of the two gross weight.If miscella is less than 60% (weight), the ability of permeates cell membranes is just poor.On the other hand, just low if miscella surpasses 95% (weight) as the concentration of the antioxidant of effective ingredient, will weaken so suppress the ability of active oxygen and lipid peroxidation deposits yields.
The oral Oily preparation of the present invention is preparation like this; Oil mixture one is made and, and just fine powder is joined in this oil mixture, and seals the inside of ' Yanming ' capsules for clearing into or analog.Yet before sealing capsule, mixed material was descended ripe about 3～30 days, at 20～35 ℃ more preferably 28～30 ℃ of following ripe weeks.
Handle by maturation, further continue to discharge antioxidant and carry out the low-molecular-weight conversion of antioxidant owing to remain with Japanese fermented preparation in the fine powder, antioxidant attaches on the oil mixture better, so just further improved the activity and the ability that is penetrated in the cell of active component.
Oily preparation of the present invention also comprises a kind of cereal materials, it comprises Oryza glutinosa plumelet or Semen Tritici aestivi plumelet and Semen sojae atricolor, at least a arbitrarily Testa oryzae, hatomugi (pearl barley) or Semen Tritici aestivi, these materials are without heating with brewage, make fine powder, and in the mixture that above-mentioned heating and the fine powder brewageed are added to.
Antioxidant as effective ingredient can not discharge and change into low-molecular-weight material in the fine powder of the cereal materials that does not heat and brewageed, yet, when it is added in the miscella with heating and the fine powder brewageed, release and the low-molecular-weight that will carry out polyphenoils gradually transform, even also can be like this after enclosing capsule, this is owing to the still residual cause that Japanese fermented preparation is arranged in the fine powder of brewageing, so it has such advantage, can maintain the effect that suppresses active oxygen and lipid peroxidation deposits yields exactly for a long time.
On the contrary, in the Oily preparation of the fine powder that only uses heating and brewageed, because enzyme reaction and course of reaction continuously similar even encapsulate after, be decomposed gradually as the antioxidant of effective ingredient, so effect duration makees preparation and lacks than adding untreated fine powder.
But adding under the too many situation of untreated fine powder, the activity of effective ingredient reduces.Therefore, preferably about 0.5-1 part of the amount of untreated fine powder (weight) (based on the heating of 1 part of weight and the fine powder of brewageing).By the way, also have under the situation that comprises two class fine powders, oil mixture is 60～95% of a gross weight.
In the Oily preparation that obtains like this according to the present invention, the activity of antioxidant and the ability that penetrates in the cell are all very high, also as the result proved of described clinical trial hereinafter, said preparation obviously shows the effect of anti-various inflammation and chronic refractory disease, has not had enough curative effects for the general antiinflammatory of these diseases.
Oily preparation of the present invention can carry out capsule with gelatin etc. and seal as oral drugs.In addition, in unusual pigmentation, for example dermatitis, moth patch, freckle etc., or in the situation of wrinkle etc., Oily preparation can be applied directly to site of action.
Remove outside dermatitis and the similar disease, also can be used for adult's disease and chronic refractory disease to this Oily preparation, for example beaevais' disease, thrombophlebitis, carry out system's sclerosis, thromboangiitis obliterans, raynaud disease, intractable cutaneous ulcer and similarly sick.Preparation of the present invention is to treatment and prevent disease that other various pollutions cause, burn, wound, fatigue, be still drank after a night, constipation and class be also effective with disease.
In addition, because Oily preparation of the present invention only uses corn, Japanese fermented preparation and Semen Sesami as raw material, be free from side effects, so it can and increase healthy oral health protection food as maintenance, much less, when producing preparation, can arbitrarily add various ancillary drugs or to healthy and helpful composition, for example, various vitamin, mineral and analog, and odorant and flavoring agent, coloring agent etc.
Example approach
Each Oryza glutinosa plumelet of 1 part, Semen sojae atricolor, Testa oryzae, hatomugi (pearl barley) and Semen Tritici aestivi all are added in the ceramic pot of the far ir ray that can launch 4～14 μ m, under 90～96 ℃, slowly stir heating down 3 hours, can not burn.3% the Japanese fermented preparation that then adds total amount brewageed under 36～40 ℃ 72 hours, and the material that will brewage with a stone grinder is ground into fine powder then.In addition, above-mentioned five kinds of cereal materialses that do not heat and brewageed also are ground into the fine powder of same amount with stone grinder with it.On the other hand, heat Semen Sesami, and on stone grinder, press after the porphyrize and obtain sesame paste oil in the mode identical with above-mentioned serial material.
Then, the sesame paste of 28.1 parts (weight) oil is mixed with the commercially available Oleum sesami of 48.9 parts (weight), in this mixture adding 11.5 parts (weight) heat and the fine powder brewageed and 11.5 parts (weight) without heat treated fine powder; The mixture that obtains stirs.The gained mixture was sealed with gelatine capsule then 28 ℃ of following ripe weeks, just obtained Oily preparation.
Effect of the present invention (I) is tested in teat glass
(1) reaches and penetrates the ability of oil drop for test in teat glass, the Oily preparation of embodiment is added in TBA (thiobarbituric acid) response system, oiliness unsaturated fatty acid (docosahexenoic acid) and the reactive oxygen species that produces by ultraviolet in this system, and the generation lipid peroxide, measure the degree that suppresses the lipid peroxidation deposits yields.
In other words exactly the Oily preparation test specimen of the present invention of 1.8mg/ml is added in the docosahexenoic acid (decosahexaenoic acid) of the 0.1CC that has diluted 100 times, with the lipid peroxide of TBA reaction assay generation.In the TBA reaction, the 0.1N Hcl of the sodium lauryl sulphate of 0.2ml 7%, 2ml and the phosphotungstic acid of 0.3ml are mixed, again the test specimen of 1.8mg/ml is added in the mixed liquor; The TBA of adding 1ml 0.67% and acetic acid utilize spectrofluorophotometer in the stimulation of 515nm place with in the radiation of 553mm place with 1: 1 blended reagent, measure.
Routine in contrast, with the nutrient for plants of Japan Patent 1366268 (comparative example 1) with in Japanese unexamined patent, the described anti-oxidant compositions of publication number 63-79834 (comparative example 2) is measured with the same manner, the results are shown in table 1.
Table 1
| Test specimen | On average (6 minutes values) |
| Controlled trial (UV+) | 41±62 |
| Oily preparation of the present invention (1.8mg/ml) | 121±13 *** |
| Comparative example 1 (1.8mg/ml) | 271±34 ** |
| Comparative example 2 (1.8mg/ml) | 358±45 * |
UV+: ultraviolet radiation
* *: 0.01＜P＜0.05 (comparing (V.S.control)) with controlled trial
*: P＜0.01 (comparing (V.S.control)) with controlled trial
*: P＜0.0001 (comparing (V.S.control)) result of the test with controlled trial
Though any one test specimen all suppresses widely through ultraviolet radiation (Oz), and the lipid peroxide (TBA reacting substance) that produces from unsaturated fatty acid (docosahexenoic acid), but Oily preparation of the present invention has suppressed the generation (P＜0.0001) of lipid peroxide especially significantly.This result has supported such practical work, and Oily preparation promptly of the present invention has the active and higher intracellular ability of diseased part that penetrates into of higher antioxidant than general preparation (Comparative Examples 1 and 2).
(2) [3,4-
3H
2] antioxidant prepares like this, wherein use isotope (
3H) the low-molecular-weight antioxidant that comprises in the labelling Oily preparation of the present invention.It is put into the tissue of pipe; With the scintillation counter measurement be bonded on the cell membrane [
3H
2] number (cpm), whereby, measure the ability (tritium-labeled thymidine is 2ci/mM) that reaches cell membrane.
Comparative Examples 1 and 2 is also tested equally.The results are shown in Table 2.As table 2 show, Oily preparation of the present invention and Comparative Examples 1 and 2 relatively, the affinity maximum of cell membrane.
Table 2
| Test specimen | The CPm combination |
| Controlled trial | 15643cpm/10 3Cell |
| Oily preparation of the present invention (1.8mg/ml) | 56372cpm/10 3Cell |
| Comparative example 1 (1.8mg/ml) | 33451cpm/10 3Cell |
| Comparative example 2 (1.8mg/ml) | 30567 cpm/10 3Cell |
(3) Oily preparation of the present invention is through supersound process, and is added in the system that produces active oxygen (neutrophil and xanthine-xanthine oxidase) and measures three kinds of active oxygen (O simultaneously so that the live body concentration that transforms becomes 1.6mg/ml
2 -, H
2O
2And OH) and with the situation that does not add preparation (contrast) compare.Transforming live body concentration is that hypothesis is present in the amount in the blood to the common dose (9 grams are under the situation of Oily preparation of the present invention) of working as every day when being absorbed in the live body.The assay method of three kinds of active oxygens is as follows:
For O
2 -, measure with following method: utilize the Beckman spectrophotometer to measure by O at 550nm wavelength place
2 -The amount of the siderophore pigment C that reduces, and change into O
2 -Amount.
For H
2O
2, depend on the following fact, promptly in the presence of peroxidase, H
2O
2To the epipolic minimizing that Liang Rong Ting produces, by using Liang Rong Ting and peroxidase, the fluorescence of measuring Liang Rong Ting with the spectrofluorophotometer (excitation wavelength and 460mm emission wavelength with 370mm) of Hitachi Ltd. manufacturing reduces degree.
For OH., (α-keto-Methiol-butylicacid) (KMB) produces this principle of ethylene gas with the OH. reaction, uses such method, wherein with the gas chromatograph of Hitachi Ltd. manufacturing to utilize α-ketone-methanthiol-butanoic acid, ethylene gas is quantitative, change into OH. again.Comparative Examples 1 and 2 is also carried out same test, the results are shown in the table 3.
Table 3
| The test specimen test specimen | Active oxygen | ||
| O 2 - | H 2O 2 | OH. | |
| Controlled trial | 1.532nmol | 485Pmol | 854Pmol |
| Oily preparation of the present invention (1.8mg/ml) | 0.589nmol | 161Pmol | 283Pmol |
| Comparative Examples 1 (1.8mg/ml) | 1.285nmol | 403Pmol | 707Pmol |
| Comparative Examples 2 (1.8mg/ml) | 0.231nmol | 538Pmol | 108Pmol |
Result of the test
The antioxidation of Oily preparation of the present invention is a little less than Comparative Examples 2, but the antioxidation than Comparative Examples 1 performance is strong again.But as above-mentioned table 1 and table 2 proof, the oily matter that Comparative Examples 2 contains is less, so the ability that penetrates the ill cell of arrival that it has.
So, from taking it all round, Oily preparation of the present invention, its antioxidation is strong, and the ability that penetrates into the cell interior in the disease part is the strongest, and it is classic as antioxidant.
Clinical trial
To 96 autoimmune diseases, collagen diseases, for example, beaevais' disease, phthiremia, nephritis, hepatitis interstitialis chronica, moth patch, freckle and similar patient carry out the therapeutic effect investigation, and these patients have Drug resistance or stronger repellence to the anti-oxidant compositions of any non-steroidal anti-inflammatory medicine and steroid medicine and Comparative Examples 2.
The results are shown in table 4.
Table 4 test specimen
| Disease | Oily preparation of the present invention (1.8mg/ml) | Comparative Examples 1 (1.8mg/ml) | Comparative Examples 2 (1.8mg/ml) |
| Beaevais' disease | 13/18(72％) | 0/7(％) | 4/14(28％) |
| Vasculitis | 3/5(60％) | 0/3(0％) | 1/4(25％) |
| Carrying out property system sclerosis | 9/12(75％) | 2/10(20％) | 6/12(50％) |
| Dermatomyositis | 6/8(75％) | 2/12(16％) | 6/13(46％) |
| Thrombophlebitis | 2/3(66％) | 0/4(0％) | 1/5(20％) |
| Thromboangiitis obliterans | 6/8(75％) | 0/3(0％) | 3/6(50％) |
| Raynaud disease | 10/12(83％) | 3/8(37％) | 7/12(58％) |
| The varicosis of foot | 8/11(72％) | 4/9(44％) | 11/15(73％) |
| Intractable cutaneous ulcer | 3/5(60％) | 1/5(20％) | 2/6(33％) |
| Moth patch, freckle | 11/14(78％) | 4/12(33％) | 17/25(68％) |
Claims (7)
1. Oily preparation makes by following method:
The cereal materials that will contain Oryza glutinosa plumelet and/or Semen Tritici aestivi plumelet and Semen sojae atricolor heats being no more than under 100 ℃ the temperature;
To add superheated material and wear into fine powder;
In granular material, add Japanese fermented preparation, and brewage granular material;
The material of brewageing like this is added in the oil mixture, this oil mixture contains pasty state oil that obtains and the oil that obtains from living Semen Sesami from the Semen Sesami that heats under being lower than 100 ℃ temperature, wherein said oil mixture is 60～95 weight % with the ratio of the total amount of fine powder and oil mixture.
2. according to the Oily preparation of claim 1, it also comprise with contain the Oryza glutinosa plumelet and or the cereal materials of Semen Tritici aestivi plumelet and Semen sojae atricolor without heating with brewage and make fine powder.
3. according to the Oily preparation of claim 1, the cereal materials of wherein said heating and not heating also comprises at least a Testa oryzae, pearl barley or Semen Tritici aestivi except comprising Oryza glutinosa plumelet and/or Semen Tritici aestivi plumelet and Semen sojae atricolor.
4. according to the Oily preparation of claim 1 or 2, it uses the capsule package with oral as medicine or health food.
5. method for preparing Oily preparation, wherein claim 1 or 3 cereal materials wavelength are the far-infrared light heating of 4～14 μ m.
6. a method for preparing Oily preparation was wherein being brewageed under 20～36 ℃ 2～6 days behind the heat treatment according to the cereal materials of claim 1 or 3.
7. method for preparing Oily preparation wherein will be added in the oil mixture according to claim 1,2 or 3 fine powder, so as 20～35 ℃ ripe 3～30 days down.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4162666A JP2955126B2 (en) | 1992-06-22 | 1992-06-22 | Pharmaceutical oleaginous preparation, food oleaginous preparation and production method thereof |
| JP162666/1992 | 1992-06-22 | ||
| JP162666/92 | 1992-06-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1087531A CN1087531A (en) | 1994-06-08 |
| CN1065433C true CN1065433C (en) | 2001-05-09 |
Family
ID=15758977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93109052A Expired - Lifetime CN1065433C (en) | 1992-06-22 | 1993-06-22 | Oily preparation and method of production thereof |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JP2955126B2 (en) |
| KR (1) | KR0138738B1 (en) |
| CN (1) | CN1065433C (en) |
| AT (1) | AT406935B (en) |
| AU (1) | AU656681B2 (en) |
| BE (1) | BE1006911A3 (en) |
| CA (1) | CA2098893C (en) |
| CH (1) | CH686482A5 (en) |
| DE (1) | DE4320526C2 (en) |
| DK (1) | DK169714B1 (en) |
| ES (1) | ES2049189B1 (en) |
| FR (1) | FR2692442B1 (en) |
| GB (1) | GB2268185B (en) |
| HK (1) | HK1007165A1 (en) |
| IS (1) | IS1657B (en) |
| IT (1) | IT1266950B1 (en) |
| NL (1) | NL193398C (en) |
| NO (1) | NO306932B1 (en) |
| SE (1) | SE512781C2 (en) |
| TW (1) | TW269630B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2946548A (en) * | 1956-09-10 | 1960-07-26 | Lars G V Largelins | Supporting clamp |
| GB9509811D0 (en) * | 1995-05-15 | 1995-07-05 | Cerestar Holding Bv | Co-pressing of oilseeds |
| DE19715878A1 (en) * | 1997-04-16 | 1998-10-22 | Pharmaberatung Fuer Ernaehrung | Products to aid the treatment of atopic dermatitis |
| JPH11269066A (en) * | 1998-03-20 | 1999-10-05 | Kao Corp | Skin-bleaching agent for peroral administration and skin-bleaching food |
| AUPP574298A0 (en) * | 1998-09-07 | 1998-10-01 | Jacobs, David Ian | Pharmaceutical preparation |
| JP2000159682A (en) * | 1998-09-17 | 2000-06-13 | Kozo Niwa | Method of strengthening antitumor activity of crude drug, composition containing crude drug for strengthening antitumor activity, method of evaluating antitumor effectivity treated by crude drug and method of evaluating antitumor effectivity of crud drug |
| JP2000239187A (en) | 1999-02-22 | 2000-09-05 | Dotto:Kk | Transnasal absorption composition |
| JP2001199892A (en) * | 2000-01-17 | 2001-07-24 | Kozo Niwa | Method for enhancing antitumor activity of amygdalin- containing material, composition containing amygdalin- containing material for enhancing antitumor activity, method for evaluating antitumor effectiveness of treatment by amygdalin-containing material, and method for evaluating antitumor effectiveness of amygdalin- contaning material |
| JP4621444B2 (en) * | 2004-06-18 | 2011-01-26 | 株式会社ヴァリダックス | Method for producing antitumor substance |
| DE102007011985B4 (en) | 2007-03-09 | 2022-10-20 | Markus Greim | Mortar measuring cell for rotation viscometer |
| FR2956324A1 (en) * | 2010-01-18 | 2011-08-19 | Valerie Baille | Plant complex, useful to e.g. prepare a composition in pharmaceutical, cosmetic or nutrition, comprises a bamboo polyphenolic extract, a cell preparation of Ginkgo biloba and a rice bran oil preparation |
| CN104178334A (en) * | 2013-05-24 | 2014-12-03 | 北京中天金谷粮油工程技术有限公司 | Process for infrared baking of sesame to produce oil |
| JP2021031440A (en) * | 2019-08-26 | 2021-03-01 | 雄二 松川 | Antitumor agent set having active oxygen removing agent containing low molecular antioxidizing compound derived from natural product and immunity activator derived from natural product which is used for enhancing macrophages and lymphocytes |
| JP2021031439A (en) * | 2019-08-26 | 2021-03-01 | 雄二 松川 | Method for producing active oxygen scavenger for oral ingestion that suppresses runaway of immune cells and protects against dna and telomere damage |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59227876A (en) * | 1983-06-07 | 1984-12-21 | Agency Of Ind Science & Technol | Separation of tocopherols |
| JPH023495A (en) * | 1988-06-13 | 1990-01-09 | Okuno Seiyaku Kogyo Kk | Antioxidant |
| JPH04139132A (en) * | 1990-09-28 | 1992-05-13 | Asahi Breweries Ltd | Anti-active oxygen action composition, anti-active oxygen agent, food, cosmetic and medicine containing the same as active ingredient |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60110269A (en) * | 1983-11-18 | 1985-06-15 | Kimimoto Wada | Preparation of vegetable nutrient |
| JPS6236327A (en) * | 1985-08-08 | 1987-02-17 | Kozo Niwa | Chinese herbal remedy |
| JPS6379834A (en) * | 1986-09-25 | 1988-04-09 | Kozo Niwa | Active oxygen suppressive composition |
| JPH0441436A (en) * | 1990-06-04 | 1992-02-12 | Sodetsukusu Kk | Antioxidant composition |
| JP3357383B2 (en) * | 1991-08-14 | 2002-12-16 | 昌宏 黒田 | Low molecular weight plant composition |
| JP2647774B2 (en) * | 1991-11-28 | 1997-08-27 | 株式会社 エイオーエイ・ジャパン | Plant antioxidant composition |
-
1992
- 1992-06-22 JP JP4162666A patent/JP2955126B2/en not_active Expired - Lifetime
-
1993
- 1993-06-21 SE SE9302141A patent/SE512781C2/en unknown
- 1993-06-21 NO NO932282A patent/NO306932B1/en not_active IP Right Cessation
- 1993-06-21 CH CH186493A patent/CH686482A5/en not_active IP Right Cessation
- 1993-06-21 DK DK073293A patent/DK169714B1/en not_active IP Right Cessation
- 1993-06-21 IT IT93TO000448A patent/IT1266950B1/en active IP Right Grant
- 1993-06-21 GB GB9312763A patent/GB2268185B/en not_active Expired - Lifetime
- 1993-06-21 DE DE4320526A patent/DE4320526C2/en not_active Expired - Lifetime
- 1993-06-21 CA CA002098893A patent/CA2098893C/en not_active Expired - Lifetime
- 1993-06-22 ES ES09301404A patent/ES2049189B1/en not_active Expired - Fee Related
- 1993-06-22 IS IS4038A patent/IS1657B/en unknown
- 1993-06-22 KR KR1019930011403A patent/KR0138738B1/en not_active IP Right Cessation
- 1993-06-22 CN CN93109052A patent/CN1065433C/en not_active Expired - Lifetime
- 1993-06-22 AT AT0122893A patent/AT406935B/en not_active IP Right Cessation
- 1993-06-22 FR FR9307557A patent/FR2692442B1/en not_active Expired - Lifetime
- 1993-06-22 NL NL9301083A patent/NL193398C/en not_active IP Right Cessation
- 1993-06-22 BE BE9300641A patent/BE1006911A3/en not_active IP Right Cessation
- 1993-06-22 AU AU41432/93A patent/AU656681B2/en not_active Expired
- 1993-06-22 TW TW082104986A patent/TW269630B/zh not_active IP Right Cessation
-
1998
- 1998-06-24 HK HK98106356A patent/HK1007165A1/en not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59227876A (en) * | 1983-06-07 | 1984-12-21 | Agency Of Ind Science & Technol | Separation of tocopherols |
| JPH023495A (en) * | 1988-06-13 | 1990-01-09 | Okuno Seiyaku Kogyo Kk | Antioxidant |
| JPH04139132A (en) * | 1990-09-28 | 1992-05-13 | Asahi Breweries Ltd | Anti-active oxygen action composition, anti-active oxygen agent, food, cosmetic and medicine containing the same as active ingredient |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU596701B2 (en) | Antioxidant composition and production method thereof | |
| CN1065433C (en) | Oily preparation and method of production thereof | |
| NL1019705C2 (en) | Method for assessing the effectiveness of a treatment of a crude drug to enhance the anti-tumor activity, and method for assessing the anti-tumor effectiveness of a raw drug. | |
| KR102265592B1 (en) | Composition containing 5-aminolevulinic acid hydrochloride | |
| WO1995018626A1 (en) | A tonic drug made from basidiomycetes, algae, chinese herbal medicine and the method thereof | |
| KR101893012B1 (en) | Method for Manufacturing Soap Containing Fermented Medicinal Herbs Include Ginseng | |
| NL1017117C2 (en) | Method for enhancing the anti-tumor activity of an amygdalin-containing material, preparation containing enhanced amygdalin-containing material, method for assessing the anti-tumor effectiveness of a treatment of amygdalin-containing material, and method for evaluating amygdalin-containing anti-tumor material. | |
| JP3779740B2 (en) | Agents for preventing and treating obesity from rice | |
| RU2195306C1 (en) | Biologically active substances extraction method | |
| KR20090097832A (en) | Whitening cosmetics containing irradiated cooking drips and irradiated extract of cooking drips from seafood | |
| EP1161253A1 (en) | Use of hop flowers for medicinal treatments |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| FG4A | Grant of patent | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CX01 | Expiry of patent term |
Expiration termination date: 20130622 Granted publication date: 20010509 |