JPH11269066A - Skin-bleaching agent for peroral administration and skin-bleaching food - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject bleaching agent capable of preventing or recovering the blackening of the skin such as freckle and suntan without necessitating labor and easily attaining skin-bleaching effect by using an isoflavone compound as an active component. SOLUTION: This agent contains an isoflavone compound, e.g. a compound expressed by formula I R<1> is H or hydroxyl; R<2> is H, hydroxyl or a 1-6C alkoxy; R<3> is H or a group of formula II [R<4> is H, CO(CH2 )n R<5> or the like; R<5> is H or COOH; (n) is 1-5]}, especially isoflavone, etc., as an active component. The compounding amount of the isoflavone is 0.002 wt.% and the isoflavone is preferably administered at a daily dose of about 1-120,000 mg for >=10 days for an adult.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening agent and a whitening food having an oral whitening effect.

[0002]

2. Description of the Related Art One of the most cosmetic concerns for women is skin spots and freckles. It is considered that such spots and freckles are generally generated by stimulating melanocytes due to stimulation by ultraviolet rays, hormonal abnormalities, etc., and depositing the melanin pigment biosynthesized there on the skin.
Conventionally, such spots and freckles are treated by adding a melanin inhibitor such as ascorbic acid, hydroquinone derivative, kojic acid, isoflavone glycoside, placenta extract to cosmetics and applying it to the skin. The method has been mainly used.

[0003] In addition, on the skin exposed to ultraviolet light, primary melanin, which is primarily oxidized by light-colored melanin, becomes black, and the function of melanocytes is enhanced, and the amount of melanin in epidermal cells increases, resulting in secondary black. The formation occurs (sunburn). It takes several months or more for the skin with advanced darkening to return to its original color. For this reason, sunscreens and the like have been used to recover from excessive sunburn.

[0004]

However, ascorbic acids, hydroquinone derivatives, kojic acids, placental extracts, and the like have a weak melanin-suppressing effect and cannot exhibit a sufficient whitening effect even when incorporated into cosmetics. In addition, isoflavone glycosides have an excellent whitening effect, but it is not easy to apply isoflavone glycoside-containing cosmetics to the whole body when spots and freckles occur on the whole body, and the burden on the user is large. In addition, it was difficult to recover the blackening of the skin caused by sunburn or the like with sunscreen or the like. Furthermore, it has been difficult to prevent the occurrence of freckles and sunburn with the ascorbic acids and sunscreens.

Accordingly, an object of the present invention is to provide a whitening composition which can easily obtain a whitening effect by preventing or restoring blackening of skin such as freckles and sunburn without labor. And

[0006]

Means for Solving the Problems The present inventors have conducted intensive studies in order to achieve the above object, and as a result, surprisingly, isoflavones can prevent or recover freckles and blackening such as sunburn when administered orally, and provide excellent results. The present invention has been found to have a whitening effect.

That is, the present invention provides an oral whitening agent containing isoflavones as an active ingredient. The present invention also provides a whitening food containing isoflavones.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The isoflavones used in the present invention are isoflavones and derivatives thereof, and the isoflavone derivatives represented by the following general formula (1)

[0009]

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(Wherein, R ¹ represents a hydrogen atom or a hydroxyl group, R ² represents a hydrogen atom, a hydroxyl group or an alkoxyl group having 1 to 6 carbon atoms, and R ³ represents a hydrogen atom or the following general formula (2) )

[0011]

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(Wherein R ⁴ is a hydrogen atom or CO (C
H2) _n R ⁵ (wherein n represents an integer of 1 to 5, and R ⁵ represents a hydrogen atom or COOH). ). ) Are preferred. R ²
Is particularly preferably a hydrogen atom or a methoxy group. R ³ is a hydrogen atom or R ⁴ in the general formula (2) is a hydrogen atom;
Acetyl group, 2-carboxyethanoyl group or 3-
Particularly preferred is a carboxypropanoyl group.
As the most preferred isoflavones, isoflavones,
Daidzin, glycitin, genistin, 6'-O-acetyldaididine, 6'-O-acetylglycitin, 6'-O
-Acetylgenistin, 6'-O-malonyl daidzin,
6'-O-malonylglycitin, 6'-O-malonylgenistin, 6'-O-succinyl daidzin, 6'-O-
Succinylglycitin, 6'-O-succinylgenistin, daidzein, glycitein, genistein. In the present invention, one or more of these isoflavones or isoflavone derivatives can be used.

All such isoflavones are known compounds. Isoflavone does not exist in nature, and for example, 7-hydroxyisoflavone can be synthesized from dihydroxyphenylbenzylketone and methyl orthoformate in the presence of a base. Isoflavone derivatives can also be synthesized from isoflavones, but are included in plants such as legumes, roses, and irises; for example, legumes, preferably soybeans, and particularly preferably lower alcohols such as methanol from ground defatted soybeans. Can be used for extraction. The isoflavone derivative used in the present invention may be a crude extract or a purified product. Also, commercially available products can be used. Examples of commercially available products include Fujiflavone P40 (manufactured by Fujikko).

The oral whitening agent of the present invention is prepared by formulating such isoflavones into solid preparations such as powders, granules, capsules, pills and tablets, or liquids such as solutions, suspensions and emulsions. can get. Upon formulation, excipients, binders, disintegrants, lubricants, coatings, bases, suspending agents, emulsifiers, humectants, preservatives, stabilizers, and surfactants commonly used for oral administration Activators, flavoring agents and the like can be added to produce the composition according to a conventional method.

[0015] Such isoflavones can also be incorporated into foods. Thereby, isoflavones can be taken without difficulty. The food containing the isoflavones is not particularly limited, and may be in any form such as liquid or paste food such as juice, milk, curry, solid food such as gum, tofu, or powdered preserved food. The isoflavones may be added as a part of the raw material at the time of producing the food, or may be added after the production of the food.

The compounding amount of the isoflavones in the oral whitening agent and the whitening food is, for example, preferably 0.002% by weight or more, particularly preferably 0.02 to 40% by weight. Within this range, formulation is easy and isoflavones can be ingested efficiently.

The isoflavones per adult person
The daily intake depends on the age, health condition, weight, etc., but is generally 1 to 120, in the case of prevention or recovery of sunburn.
Preferably, the dose is 2,000 mg, especially 10 to 12,000 mg, and such intake is preferably continued for at least 10 days, especially at least 20 days.

[0018]

EXAMPLES Next, the present invention will be described in more detail by way of examples, but the present invention is not limited to the following examples.

Test Example 1 Confirmation of Whitening Effect of Darkened Skin Half of the back of a female 6-week-old colored guinea pig was shaved, and a 1.2 mW UV lamp was applied to the shaved portion on the first day for 5 minutes.
On the second and third days, 1.0 mW was irradiated for 5 minutes. After two weeks, these guinea pigs were divided into four groups (5 to 6 animals per group) so that there was no difference in the degree of ultraviolet-induced pigmentation, and soybean-derived isoflavones were added to commercially available solid feed (RC4, manufactured by Oriental). Derivative-containing feed (Fujiflavone P40 (manufactured by Fujico)) is 0% by weight (Group 1), 0.02% by weight (Group 2), 0.2% by weight (Group 3) and 2% by weight of isoflavone derivatives. % (Group 4) was started. The daily feed intake per animal in each group was 50 g / day. Color difference meter (Nippon Denshoku Industries Co., Ltd. 1)
001DP). That is, the same point was subjected to color difference measurement at five points, the average L value was taken as the L value of the solid, and the average L value of each group was determined. Next, L on the feeding start date
The difference dL from the value (L ₀ value) was calculated. The results are shown in FIG. FIG. 1 shows the dL of each group on each measurement day, and shows that the higher the dL, the greater the recovery of pigmentation (darkening) due to ultraviolet rays on the skin.

From FIG. 1, it was confirmed that in the first group which did not take the isoflavone derivative-containing feed, the blackening progressed until the third week, and the recovery thereafter was slow. On the other hand, the 2nd to 4th groups that took the isoflavone derivative-containing feed were 2
The recovery was rapid from the week, and the tendency was remarkable especially in the fourth group, and it was confirmed that the isoflavone derivative had a whitening effect.

Test Example 2 With respect to the guinea pigs of Groups 1, 3 and 4 used in Test Example 1, the other half of the back was shaved three weeks after the start of feeding in Test Example 1, and a UV lamp was used. 1.2mW to 5
For 1 minute, 1 day and 2 days later, 1.0 mW was irradiated for 5 minutes. In irradiation, hair removal and UV irradiation were performed in Test Example 1.
The irradiated part was covered so that UV was not irradiated again. Then obtains the L value of each group in the same manner as in Test Example 1 after two weeks depilatory date (5 weeks after feeding start date), and calculates the difference dL between the L ₀ value. The results are shown in FIG.

From FIG. 2, it was confirmed that in the first group, the blackening progressed due to the UV irradiation. On the other hand, the second group and the third group
In the group, dL was positive despite UV irradiation, and it was confirmed that the isoflavone derivative has a preventive effect against blackening due to UV irradiation.

[0023]

EFFECTS OF THE INVENTION The oral whitening agent or whitening food of the present invention is capable of preventing or recovering from blackening due to spots, freckles, sunburn, etc., and lightening the skin without requiring labor.

[Brief description of the drawings]

FIG. 1 shows the feeding period of isoflavone-containing feed.
1 shows the effect of promoting the extinction of ultraviolet-induced pigmentation for each content of isoflavones.

FIG. 2 shows the effect of preventing isoplavone-induced pigmentation after feeding isoflavones for 3 weeks for each content of isoflavones.

Claims (2)

[Claims] 1. An oral whitening agent comprising isoflavones as an active ingredient. 2. A whitening food containing isoflavones.