JPH07255416A - Nutrient auxiliary food - Google Patents

Abstract

PURPOSE:To obtain a nutrient auxiliary food containing a mucopolysaccharide protein complex and an organoselenium compound, preventing aging of skin, effective for vitality increase and nutrition enhancement. CONSTITUTION:This nutrient auxiliary food contains 1,000-3,500mg of a mucopolysaccharide protein complex and 50-200mug of an organoselenium compound in 5g of a food. Addition of 50-120mg of active alpha-type vitamin E makes the nutrient auxiliary food more effective. The nutrient auxiliary food is effective for eliminating and making inconspicuous stain formed on the skin.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dietary supplement, and more particularly to a dietary supplement effective for recovery from fatigue, enhancement of energy and prevention of skin aging.

[0002]

2. Description of the Related Art Shark fins have been used in China since ancient times for preventing aging, fortifying nutrition, beauty and the like. In recent years, it has been found that the main component of the effect is chondroitin sulfate (mucopolysaccharide), and it is used for medical purposes. In addition, sesame has been used since ancient times because it has a similar effect. The main components of this effect are said to be abundant proteins, lipids and minerals.

Oxidation of living tissues is closely related to the aging phenomenon. In particular, the oxidation of mitochondria in cells causes a failure of energy metabolism, a decrease in physical strength, a decrease in energy, and an accumulation of fatigue. It is also known that senile spots are caused by denaturation of proteins by lipid peroxide.

The aging phenomenon of the living body is also related to the aging of connective tissue, and many studies have shown that the supplementation of chondroitin sulfate having various physiological actions is effective in improving various symptoms caused by aging. Has been announced by the person.

On the other hand, it is a well-known fact that deficiency of trace essential minerals such as zinc and selenium causes a decrease in sexual function. In particular, selenium serves as a constituent of glutathione peroxidase in the body and has an action of preventing oxidation of chain reaction tissues of lipid peroxide, so that it is effective to supplement selenium to prevent a decrease in energy due to the aging phenomenon.

[0006] Furthermore, it has been found that simultaneous ingestion of selenium and vitamin E has a certain synergistic effect and can enhance sexual function.

[0007]

As described above, chondroitin sulfate and selenium each have an antiaging effect, but when only chondroitin sulfate is ingested, fatigue recovery, deterioration of visual acuity due to aging, low back pain, and dryness are caused. Although it is effective in improving the skin, its degree is not so remarkable. Further, when only selenium and vitamin E are ingested, the sexual function can be slightly enhanced or the onset of spots can be delayed, but the degree of the effect cannot be said to be sufficiently satisfactory.

The present invention focuses on the direct pharmacological effects of chondroitin sulfate, and the antioxidant and sexual function-improving effects of selenium and vitamin E. Furthermore, it enhances the permeability of tissues and digestive tract. Focusing on the fact that chondroitin sulfate has an action of increasing the absorption rate of selenium and vitamin E, such as a motility promoting action, to prevent skin aging, enhance energy,
The purpose of the present invention is to provide a nutritional supplement that is extremely effective for nutritive strong males.

[0009]

In order to solve the above problems, the dietary supplement of the present invention contains 1000 to 3 in 5 g.
500 mg of mucopolysaccharide protein complex and 50-200
It is characterized by containing μg of organic selenium.

A preferred embodiment of the dietary supplement of the present invention is
The nutritional supplement further comprises 50 to 120 mg of active α-type vitamin E.

[0011] In another preferred embodiment of the dietary supplement of the present invention, the mucopolysaccharide protein ratio of the mucopolysaccharide protein complex is 1.5 to 2.5: 2.5 to 3.5. It is characterized by that.

In another preferred embodiment of the dietary supplement of the present invention, the mucopolysaccharide protein complex is 80
It is characterized by containing ~ 90% of chondroitin sulfate and 10 ~ 20% of hyaluronic acid.

Further, another preferred embodiment of the dietary supplement of the present invention is characterized in that a shark fin extract is used as the substance containing the mucopolysaccharide protein complex.

Furthermore, another preferred embodiment of the dietary supplement of the present invention is characterized in that sesame extract is used as the substance containing the organic selenium.

[0015]

[Function] Chondroitin sulfate contained in the mucopolysaccharide protein complex is a constituent of connective tissue of the living body together with colagen. Chondroitin sulfate is
There are physiological actions such as stabilization of colagen fibers, enhancement of tissue swelling ability, enhancement of tissue permeability, scarring and keloid softening,
Further, it has physiological effects on organs such as detoxification and liver protection, promotion of intestinal peristalsis, and enhancement of diuretic effect.
In addition, it has peripheral vasodilatory effects on the circulatory organs, blood colloidal adjusting effects, etc., metabolism has intermediate metabolism adjustment, sulfur metabolism disorder improvement, etc. It has parasympathetic hyperactivity and a weak central analgesic effect.

As described above, selenium has an action of improving sexual function, and is particularly effective in improving male sexual function. This is because 30 to 40% of the selenium ingested in the male body is concentrated in the genitals. The selenium thus concentrated in the genitals is lost with the discharge of semen. Selenium is essential for healthy sperm production as well as preventing the decrease in ATP acidity due to mitochondrial oxidation. Therefore, supplementation with selenium is effective in improving energy. In addition, selenium also has the effect of preventing stains caused by skin oxidation.

Although selenium includes inorganic selenium and organic selenium, the dietary supplement of the present application is particularly composed of organic selenium. Inorganic selenium has the effect of improving energies by ingesting it, but in order to obtain a remarkable effect, it requires a large amount of ingestion, so there is a fear that side effects due to toxicity of selenium occur, which is not preferable. . Organic selenium has a large effect at a small intake amount and has no toxicity problem unless ingested in a large amount.

Vitamin E (tocopherol) has an antioxidant action, prevents peroxidation of fatty compounds, and suppresses cell aging. In particular, the use of active α-vitamin E can significantly enhance the effects of the dietary supplement of the present invention.

100 mucopolysaccharide protein complex was added to 5 g.
0 to 3500 mg and 50 to 200 μg of organic selenium
By taking an appropriate amount of dietary supplement containing
Due to the synergistic action of these components, the present inventor is found to have extremely excellent effects such as improvement of sexual function, improvement of water retention capacity of skin, and improvement of stains, and is also effective for various indefinite complaints. Revealed by

Furthermore, when 50 to 200 mg of active α-type vitamin E is simultaneously ingested in addition to the above components, a more remarkable improvement in the effect is observed. In addition, active α-type vitamin E
Only enhances the synergistic effect and addition of other types of vitamin E does not show a significant increase in effect.

The mucopolysaccharide protein complex preferably has a mucopolysaccharide protein ratio of 1.5 to 2.5: 2.5 to 3.5, and the mucopolysaccharide protein complex has a ratio of 80 to 9.
It is preferably composed of 0% chondroitin sulfate and 10 to 20% hyaluronic acid. This is because the human body has such a composition, and it is preferable to use a composition close to that of the living body. This is supported by the so-called tissue specificity theory.

Chondroitin sulfate which prevents the aging of connective tissue is contained in soft-shelled turtles, tongue legs, sea cucumbers, duck skins, etc., and it is particularly preferable to use those extracted from shark fins. The shark fin extract contains, in addition to chondroitin sulfate, hyaluronic acid, protein, calcium, phosphorus and the like as mucopolysaccharides, and acts on the living body in a complicated manner. Further, it has an action to promote intestinal motility and enhance tissue permeability, and by this action, it acts to increase the cell absorption rate of selenium and vitamin E which are simultaneously ingested.

Organic selenium having an antioxidant effect is contained in oysters, livers of cattle and pigs, lobster tails, and the like. Extracts extracted from these can be used. Contains a large amount of heavy metals at the same time, and since the heavy metal and selenium combine to reduce the antioxidant capacity, it is preferable to use organic selenium extracted from sesame cultivated in soil containing a large amount of selenium. .

Shark fin extract containing 2000 to 3500 mg of chondroitin sulfate in 5 g and 50 to 200 μg
Sesame extract containing organic selenium of 50 to 200
By orally ingesting a dietary supplement containing mg active α-vitamin E, it is possible to maintain good male genital condition and significantly improve sexual function and skin preservation, as is clear from the following experimental examples. It can improve water power and improve dry skin to moisturized skin. Further, it is possible to obtain the effect of eliminating or eliminating the stains formed on the skin. In addition, improvement of indefinite complaints such as fatigue is seen.

When chondroitin sulfate is ingested in excess of the above upper limit of intake, various symptoms such as rash, loss of appetite, insomnia, and excitement may occur. 1560 chondroitin sulfate
Mucopolysaccharide protein complex containing mg 39 per day
It has been reported that the above-mentioned side effects occurred in 1.6% of patients when they continued to take 00 mg for a very long period. (Dr. Miwa, Tokai University School of Medicine). Originally, since foods should have no side effects, foods exceeding the above intake amount are unsuitable as foods. In addition, if ingested above the lower limit of the above ingredients, the effect will be significantly diminished. Even if the mucopolysaccharide protein complex containing 400 mg of chondroitin sulfate is continuously ingested at 1000 mg per day, the effect according to the present invention does not appear.

The National Committee for Chemistry Research in the United States states that a suitable daily intake of selenium for an adult is 50 to 200 μg. In addition, many selenium researchers set the daily intake of adults at 250 to 350 μg as a guide. Experimentally, 5000 μg per day
It is said that if it is ingested in excess of the above, symptoms such as hair and nails getting out will appear. Usually 50 to 150 from a typical diet
Since μg of selenium is ingested, it is preferable that the dietary supplement should be ingested at an upper limit of 200 μg per day. The intake as a dietary supplement is 50μ
Below g, the effect of the present invention is not observed.

The daily intake of vitamin E is 50
~ 200 mg is preferred. No harm has been observed due to excessive intake of vitamin E, but if it is ingested more than necessary, it will be excreted outside the body, or it will be meaningless, or
Accumulation in body fat is undesirable. In order to expect the antioxidative effect of vitamin E, it is necessary to ingest at least 50 μg per day. Considering the decrease of vitamin E due to stress and smoking, some people need to take about 200 mg.

[0028]

EXAMPLES Examples of the present invention will be described in detail below.

Comparative Example 1 Administration of Food Containing Chondroitin Protein Complex (Food Composition) Tablet containing 180 mg of edible chondromucotan white (manufactured by Taiyo Fisheries Co., Ltd.) extracted from shark fin in one tablet Prepared dietary supplements. The chondroitin protein complex contained in this edible chondromucotan protein had a mucopolysaccharide protein ratio of 2: 3 and 90%.
Of chondroitin sulfate and 10% hyaluronic acid.

(Subjects to be administered) 20 adult males complaining of decreased energy, 20 adult females complaining of rough skin (stains and dry skin)
The above dietary supplements were administered to the first name. Of these patients, 35 (17 men, 18 women) complained of fatigue as an incidental symptom. It did not matter what the underlying disease was in these patients.

(Method of administration) 4 tablets a day, 3 tablets a day
It was taken for 30 to 60 days after each meal. In addition, the target user took the medicine that has been conventionally used as it is, and had each person continue their life as usual. However, we have decided not to take additional medications.

(Judgment) Men's patients were evaluated for improvement of their energy, and female patients were evaluated for improvement of rough skin. We also evaluated the improvement of blemish in patients who are concerned about stains regardless of gender. Furthermore, for patients complaining of tiredness, a determination was made as to improvement of tiredness.

(Determination Method) The degree of improvement of each symptom was determined based on the following method. Judgment of improvement of energy level Stamp NPT test (Kinbara Publishing Co., Ltd., Impotence practice <urology MOOK
No. 3>, page 39), or an NPT test with an electrometer (same book, see the same page), and the same NPT test was carried out for 30 days after administration for 3 days to evaluate the degree of improvement in energy. .

In the stamp NPT test, the number of times stamps were cut before administration was compared with the number of times stamps were broken after administration. Was improved to a medium level, and when it was cut a lot, it was improved to a longitude. It was evaluated as unchanged when the number of stamps was the same as before administration, and was evaluated as worse when the number of stamps was decreased as compared with that before administration.

In the NPT test of the electrometer, the penile circumference was measured at the time of erection for 3 days before administration and for 3 days after administration, and the respective average values were calculated and compared. A case where the average value after administration increased by 50% or more from the average value before administration was markedly improved, and an increase of 25 to less than 50% was moderately improved, and an increase of less than 10 to 25% was improved to longitude. , 9 to -9% were invalid or unknown, and an increase of -10% or less was evaluated as worse.

Judgment of Improvement of Rough Skin Before administration of the tablet, the water retention amount on the forehead, both cheeks, each part of the face of the jaw, hand and back is measured and the average value thereof is calculated, and the administration is continued for 30 days. After the eyes, the amount of water retention at the same site was measured again, the average value was calculated, and these average values were compared to examine the degree of improvement. The water retention amount was measured by allowing the subject to take a rest for about 15 minutes, and using a water retention amount measuring instrument (SKICOS301) in a room at a temperature of about 26 degrees and a humidity of about 60%.

In the evaluation, the average value of water retention amount after administration was 20 from the average value of water retention amount of the above 5 sites before administration of the tablets.
%, It was considered to be markedly improved, and 10 to 2
If the increase is less than 0%, it is considered to be moderately improved.
The case where it increased by less than 10% was considered to have been improved to longitude. Further, when the average value increased by 4% to -5%, it was regarded as invalid or unknown, and when the average value increased by -6% or less, it was regarded as worse. When the water retention meter (SKICOS301) is used, an error of about ± 5% occurs, so such a determination was made.

Judgment of Improvement of Blots Blots were evaluated by self-observation. When the stain observed before administration of the tablet disappears after administration, or when it becomes considerably thin, it is markedly improved, when it becomes slightly thin, it is effective, when it is not replaced, it is invalid, when it becomes dark Was evaluated as worse. In addition, when there are multiple stains, the stain that the patient is most concerned about was observed and evaluated.

Improvement of feeling of fatigue In 35 patients complaining of feeling of fatigue, the degree of improvement after administration of the above tablets for 30 days or more was judged by themselves, and considerably improved, slightly improved, unchanged, deteriorated, Evaluation was made in 5 grades of unknown.

Tables 1 to 5 below show the judgment results for each symptom by the above judgment method.

[0041]

[Table 1] Improvement degree of energy decline (stamp NPT test) Number of cases Significant improvement Moderate improvement Mild improvement Invariant deterioration 10 0 0 2 8 0 Improvement rate: Moderate or higher to marked improvement 0% Mild or higher improvement 20%

[0042]

[Table 2] Improvement rate of decline in energy (Electimeter) Number of cases Significant improvement Moderate improvement Mild improvement Invariant deterioration 10 10 1 1 8 0 Improvement rate: Moderate or higher to marked improvement 10% Mild or higher improvement 20%

[0043]

[Table 3] Degree of improvement in water retention of skin (Skicos) Number of cases Significant improvement Medium improvement Mild improvement Invariant deterioration 20 2 3 5 10 0 Improvement rate: Moderate or higher to marked improvement 25% Mild or higher improvement 50%

[0044]

[Table 4] Stain improvement rate Number of cases Significant improvement Effective invalid Invalid Exacerbation 210 0 2 180 Improvement rate: Significant improvement 0.0% Effective or higher 10.0%

[0045]

[Table 5] Level of improvement in feeling of fatigue Moderate or higher to mild improvement Unchanged Deterioration Marked improvement 35 15 10 10 0 Improvement rate: Moderate or higher to marked improvement 42.8% Mild or higher improvement 71.4%

Comparative Example 2 Organic Selenium, Active α
Administration of foods containing type Vitamin E (Food composition) Prepare a tablet-shaped dietary supplement containing 6.25 μg of organic selenium extracted from sesame and 8 mg of active α-type vitamin E extracted from wheat germ in one tablet. did.

(Subjects to be administered) 20 adult males complaining of decreased energy and 20 adult females complaining of rough skin (stains and dry skin)
The above dietary supplements were administered to the first name. Of these patients, 39 (19 men, 20 women) complained of fatigue as an incidental symptom. It did not matter what the underlying disease was in these patients.

(Method of administration) 4 tablets a day, 3 tablets a day
It was taken for 30 to 60 days after each meal. In addition, the target user took the medicine that has been conventionally used as it is, and had each person continue their life as usual. However, we have decided not to take additional medications.

(Judgment) Men's patients were evaluated for improvement of their energy, and female patients were evaluated for improvement of rough skin. We also evaluated the improvement of blemish in patients who are concerned about stains regardless of gender. Furthermore, for patients complaining of tiredness, a determination was made as to improvement of tiredness.

(Determination Method) The degree of improvement of each symptom was determined in the same manner as in Comparative Example 1 described above.

Tables 6 to 10 below show the judgment results for each symptom by the above judgment method.

[0052]

[Table 6] Improvement degree of energy decline (stamp NPT test) Number of cases Significant improvement Moderate improvement Mild improvement Invariant deterioration 10 1 1 1 1 7 0 Improvement rate: Moderate or higher to marked improvement 20% Mild or higher improvement 30%

[0053]

[Table 7] Degree of improvement in energy reduction (electrometer) Number of cases Significant improvement Medium improvement Mild improvement Invariant deterioration 10 1 2 1 6 0 Improvement rate: Moderate or higher to marked improvement 30% Mild or higher improvement 40%

[0054]

[Table 8] Degree of improvement in water retention capacity of skin (Schicos) Number of cases Significant improvement Moderate improvement Mild improvement Invariant deterioration 20 0 1 3 16 0 Improvement rate: Moderate or higher to marked improvement 5% Mild or higher improvement 20%

[0055]

[Table 9] Stain improvement rate Number of cases Significant improvement Effective invalid Invalid Exacerbation 20 1 6 13 0 Improvement rate: Significant improvement 5.0% Effective or higher 35.0%

[0056]

[Table 10] Fatigue improvement number of cases Moderate or higher to mild improvement Permanent deterioration Slight improvement 39 8 11 200 Improvement rate: Moderate or higher to marked improvement 20.5% Mild or higher improvement 48.7%

First Example of the Present Invention Administration of Food Containing Chondroitin Protein Complex and Organic Selenium (Food Composition) In one tablet, edible chondromucotan white (ocean fishery )), A tablet-like nutritional supplement containing sesame extract containing 180 mg of organic selenium and 6.25 μg of organic selenium was prepared. The chondroitin protein complex contained in the edible chondromucoprotein has a mucopolysaccharide protein ratio of 2: 3 and contains 90% chondroitin sulfate and 10% hyaluronic acid.

(Subjects to be administered) 20 adult males complaining of decreased energy and 20 adult females complaining of rough skin (stains and dry skin)
The above dietary supplements were administered to the first name. At the same time, these patients complained of fatigue, insomnia, stiff shoulders, headache, dizziness, memory loss, constipation, back pain, tinnitus, numbness in the hands and feet, loss of appetite, swelling, alopecia, and decreased visual acuity. It was It did not matter what the underlying disease was in these patients.

(Administration method) As for the administration method, the above tablets 1
After taking 4 tablets 3 times a day, they were taken for 30 to 60 days. In addition, the target user took the medicine that has been conventionally used as it is, and had each person continue their life as usual. However, we have decided not to take additional medications.

(Judgment) Men's patients were evaluated for energy improvement, and female patients were evaluated for skin roughness improvement. We also evaluated the improvement of blemish in patients who are concerned about stains regardless of gender. Furthermore, the degree of improvement was also determined for the above-mentioned indefinite complaints.

(Determination Method) The degree of improvement of each symptom was determined in the same manner as in the above-mentioned comparative example with respect to the determination of improvement in energy, the determination of degree of improvement in rough skin, and the determination of stains. In addition, for the determination of other indefinite complaints, for each patient complaining of indefinite complaint, self-judgment was made on the degree of improvement after administration of the tablet for 30 days or more, and the degree of improvement was remarkably improved or moderately improved.
It was evaluated on a five-point scale: mildly improved, unchanged, and worsened.

Tables 11 to 14 below show the judgment results for each symptom by the above judgment method.

[0063]

[Table 11] Improvement rate of decline in energy (stamp NPT test) Number of cases Significant improvement Moderate improvement Mild improvement Invariant deterioration 10 1 2 3 4 0 Improvement rate: Moderate or higher to marked improvement 30% Mild or higher improvement 60%

[0064]

[Table 12] Degree of improvement in energy decline (electrometer) Number of cases Significant improvement Moderate improvement Mild improvement Invariant deterioration 10 1 3 2 5 0 Improvement rate: Moderate or higher to marked improvement 40% Mild or higher improvement 60%

[0065]

[Table 13] Improvement in water retention capacity of skin (Skicos) Number of cases Significant improvement Moderate improvement Mild improvement Invariant deterioration 20 4 6 5 5 0 Improvement rate: Medium or higher to marked improvement 50% Mild or higher improvement 75%

[0066]

[Table 14] Stain improvement rate Number of cases Significant improvement Effective invalid Invalid Exacerbation 21 1 10 9 0 Improvement rate: Significant improvement 4.5% Effective or higher 52.4%

Table 15 shows the results of the determination of the degree of improvement in indefinite complaints.

[0068]

[Table 15]

Second Embodiment of the Present Invention Administration of Food Containing Chondroitin Protein Complex, Organic Selenium Active α-type Vitamin E (Food Composition) One tablet of edible chondromucotan white extracted from shark fin ( A tablet-like dietary supplement containing 180 mg of sesame extract containing 6.25 μg of organic selenium and 8 mg of active α-type vitamin E was prepared. The chondroitin protein complex contained in this edible chondroitin protein has a mucopolysaccharide protein ratio of 2: 3, 90% chondroitin sulfate and 10%.
It contains hyaluronic acid.

(Subjects to be administered) 20 adult males complaining of decreased energy, 20 adult females complaining of rough skin (stains, dry skin)
The above dietary supplements were administered to the first name. At the same time, these patients complained of fatigue, insomnia, stiff shoulders, headache, dizziness, memory loss, constipation, back pain, tinnitus, numbness in the hands and feet, loss of appetite, swelling, alopecia, and decreased visual acuity. It was It did not matter what the underlying disease was in these patients.

(Administration method) The above-mentioned tablet was used as the administration method.
After taking 4 tablets 3 times a day, they were taken for 30 to 60 days. In addition, the target user took the medicine that has been conventionally used as it is, and had each person continue their life as usual. However, we have decided not to take additional medications.

(Judgment) Men's patients were evaluated for energy improvement, and female patients were evaluated for improvement of rough skin. We also evaluated the improvement of blemish in patients who are concerned about stains regardless of gender. Furthermore, the degree of improvement was also determined for the above-mentioned indefinite complaints.

(Determination Method) The degree of improvement of each symptom was determined in the same manner as in the above-mentioned comparative example with respect to the determination of improvement in energy, the degree of improvement in rough skin, and the determination of stains. In addition, for the determination of other indefinite complaints, for each patient complaining of indefinite complaint, self-judgment was made on the degree of improvement after administration of the tablet for 30 days or more, and the degree of improvement was remarkably improved or moderately improved.
It was evaluated on a five-point scale: mildly improved, unchanged, and worsened.

Tables 16 to 19 below show the judgment results for each symptom according to the above judgment method.

[0075]

[Table 16] Improvement degree of dysphoria (stamp NPT test) Number of cases Significant improvement Moderate improvement Mild improvement Invariant deterioration 10 2 1 5 20 0 Improvement rate: Moderate or higher to marked improvement 30% Mild or higher improvement 80%

[0076]

[Table 17] Degree of improvement in dysphoria (electrometer) Number of cases Significant improvement Moderate improvement Mild improvement Invariant deterioration 10 5 1 1 3 0 Improvement rate: Moderate or higher to marked improvement 60% Mild or higher improvement 70%

[0077]

[Table 18] Improvement in water retention capacity of skin (Skicos) Number of cases Significant improvement Moderate improvement Mild improvement Invariant deterioration 20 6 9 2 30 0 Improvement rate: Moderate or higher to marked improvement 75% Mild or higher improvement 85%

[0078]

[Table 19] Stain improvement rate Number of cases Significant improvement Effective invalid Invalid Exacerbation 21 3 11 7 0 Improvement rate: Significant improvement 15.3% Effective or higher 70.0%

Table 20 shows the determination results of the degree of improvement of indefinite complaints.

[0080]

[Table 20]

The respective judgment results in the above Comparative Examples 1 and 2 and the first and second examples of the present invention are as follows.

When a dietary supplement containing only the chondroitin protein complex was administered (Comparative Example 1), Tables 1 and 2
As shown in (4), the efficacy showing a slight improvement or more in terms of energy was about 20%, which was not a satisfactory result.
Also, regarding the water retention capacity of the skin, 50% is more than mild improvement
Then, some good results were obtained (Table 3). However, regarding the improvement of the stain, the improvement rate was 10% or more, which was lower than the effective level (Table 4). As for the feeling of fatigue, as shown in Table 5, the degree of improvement was 71.4% with a slight improvement or higher, indicating a high improvement rate.

When a dietary supplement containing only organic selenium and active α-type vitamin E was administered (Comparative Example 2),
Regarding the improvement of the energy level, the comparatively good results were obtained in 30-40% of cases in which the improvement was mild or more (Tables 1 and 2). Regarding the water retention capacity of the skin, 20% (Table 3) showed a slight improvement or more, which was not a satisfactory result. As for the improvement of stains, 35.0 or more is improved more than effective.
%, A relatively good result was obtained (Table 4). As for the feeling of fatigue, as shown in Table 5, the cases in which the improvement was mild or more were 48.7%, which was a relatively good result.

In the first example of the present invention, that is, when the dietary supplement containing the chondroitin protein complex and the organic selenium was administered, the sexual function is shown in Table 11.
And, as shown in Table 12, 60% of the persons showed a slight improvement or more, and it was possible to confirm the excellent effectiveness of the dietary supplement of the present invention. The result of the stamp NPT test is
The NPT test using an electrometer shows that the number of erections that cause the stamp to be cut has increased.
It shows that the rate of penile swelling during erection increased.

Further, in the case of the second embodiment of the present invention, that is, when a dietary supplement containing chondroitin protein complex, organic selenium, and active α-type vitamin E was administered, Table 16 and Table 17 show the sexual function. As shown in (1), 80% of the persons showed a slight improvement or more, and it was possible to confirm the extremely excellent efficacy of the dietary supplement of the present invention.

This result is considered to be a result of the action of chondroitin acting synergistically on the action of enhancing the sexual function of selenium or the action of effectively enhancing the sexual function of selenium and vitamin E. The NPT test using an electrometer and the stamp NPT test are basically diagnostic NPT tests for organic impotence, and are not NPT tests for directly judging the degree of energies, but age and sex The decline in ability and the results of the stamp NPT test are statistically proportional, and the increase in the rate of penile swelling on the electrometer can be considered as a result of energies. In addition, the majority of NPT test subjects who showed improvement in the postage stamp NPT test had more reflex erections when their sexual desire was aroused. However, it has been reported that subjective symptoms such as sufficient hardness after administration and a longer duration after insertion were improved.

Further, in the sexual function improvement test of the above-mentioned second embodiment, 3 subjects were negative in the stamp NPT test before administration of tablets, and in the NPT test using an electrometer, the penis There were 3 subjects with a swelling rate of 0, and 1 of these subjects had a past 1
He did not have sexual intercourse once every two years, and the remaining five had sexual intercourse once to five times a year. Among these, the latter 5 patients showed remarkable improvement after administration of tablets.

As for the rough skin, as shown in Tables 13 and 18, a very high result was obtained in improving the water retention capacity of the skin. In particular, in the second example, there were nine cases in which the water retention amount increased by 20% or more, and the maximum increase was 50%. By increasing the water retention capacity of the skin, it is possible to maintain a moist and moisturizing body.

Regarding the improvement of stains, Table 14 and Table 19
Good results have been obtained as shown in. In the first embodiment, 52.4% of the subjects had a slight improvement or higher, and the second
70% was found in the examples. In the two cases with pigmentation after atopy, the stain completely disappeared.
Both the self-judgment of the person and the objective judgment by the doctor were also performed, and for the rest of the patients other than atopy, the self-evaluation and the objective evaluation were almost the same.

As for other unidentified complaints, good results were obtained as shown in Tables 15 and 20.

Thus, comparing the determination results of the first and second examples of the present invention with the determination results of Comparative Examples 1 and 2, the dietary supplement of the present invention shows that chondroitin sulfate and organic selenium. Alternatively, it can be seen that the synergistic effect of chondroitin sulfate, organic selenium and active α-type vitamin E has a remarkable energetic effect, a fatigue recovery effect, a soreness improving effect, and a stain improving effect.

The daily intake of the components constituting the dietary supplement according to the present invention is 2000 to 3500 mg of mucopolysaccharide containing chondroitin and 50 of organic selenium.
~ 200μg, 50 ~ 120mg active alpha vitamin E
Is appropriate. Even if ingested in excess of the upper limits of these components, no particular abnormality is observed in the living body, but there is a concern that the harmful effect of excessive ingestion of selenium may be caused. Also, due to excessive intake of chondroitin, there are fears of side effects of foreign proteins. In addition, vitamin E is easily soluble in oil and accumulates in the body, so overdose should be avoided.

[0093]

As described above, by ingesting an appropriate amount of the dietary supplement of the present invention, it is possible to effectively supplement chondroitin sulfate, which is a constituent of connective tissue, and organic selenium having an antioxidant action and an energy-enhancing action. In combination with the action of active α-vitamin E, a remarkable effect can be obtained in enhancing energies, preventing skin aging and rough skin, and eliminating or eliminating spots on the skin.

Claims (6)

[Claims] 1. A dietary supplement characterized by containing 1000 to 3500 mg of a mucopolysaccharide protein complex and 50 to 200 μg of organic selenium in 5 g. 2. The dietary supplement further comprises 50-120.
The dietary supplement according to claim 1, which contains mg of active α-vitamin E. 3. The dietary supplement according to claim 1, wherein the mucopolysaccharide protein ratio of the mucopolysaccharide protein complex is 1.5 to 2.5: 2.5 to 3.5. . 4. The mucopolysaccharide protein complex comprises 80 to 9
The dietary supplement according to claim 1, 2 or 3, comprising 0% chondroitin sulfate and 10 to 20% hyaluronic acid. 5. The dietary supplement according to claim 1, 2, 3 or 4, wherein a shark fin extract is used as the substance containing the mucopolysaccharide protein complex. 6. The sesame extract is used as the substance containing the organic selenium,
4. The dietary supplement according to 4 or 5.