CN106540024A - A kind of antibacterial patch and preparation method thereof - Google Patents

A kind of antibacterial patch and preparation method thereof Download PDF

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Publication number
CN106540024A
CN106540024A CN201611048279.6A CN201611048279A CN106540024A CN 106540024 A CN106540024 A CN 106540024A CN 201611048279 A CN201611048279 A CN 201611048279A CN 106540024 A CN106540024 A CN 106540024A
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Prior art keywords
radix
rhizoma
herba
preparation
ethanol
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Chinese (zh)
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杨星
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LIANGJI PHARMACEUTICAL CO Ltd GUIZHOU PROV
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LIANGJI PHARMACEUTICAL CO Ltd GUIZHOU PROV
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A61K31/125—Camphor; Nuclear substituted derivatives thereof
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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Abstract

A kind of antibacterial patch, which includes fixative and flour bag, and the fixative is made up of following raw material：Radix Sophorae Flavescentiss, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Herba Agrimoniae, Radix Arnebiae (Radix Lithospermi), Flos Lonicerae, Caulis et folium gaultheriae yunnanensiss, Rhizoma Arisaematiss, Radix Aconiti, Radix Aconiti Kusnezoffii, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentiss, Caulis Spatholobi, Lignum Sappan, Lysimachia trientaloides Hemsl., Herba Asari, Sanguis Draxonis, Camphora, Herba Menthae, Myrrha, Rhizoma Chuanxiong, indomethacin, chlorhexidine acetate, ethanol.The flour bag is made up of following raw material：Radix Gentianae, Rhizoma Coptidis, Olibanum, Radix Salviae Miltiorrhizae, Herba Taxilli, Rhizoma Homalomenae, Semen Momordicae, Rhizoma Drynariae, Radix Notoginseng.Antibacterial patch provided by the present invention, can effectively suppress the growth of the floras such as skin surface escherichia coli, staphylococcus aureuses.Present invention also offers the preparation method of above-mentioned antibacterial patch.

Description

A kind of antibacterial patch and preparation method thereof
Technical field
The present invention relates to disinfection technology field, more particularly to a kind of antibacterial patch and preparation method thereof.
Background technology
Staphylococcus aureuses (Staphylococcus aureus) are a kind of important pathogens of the mankind, are under the jurisdiction of Portugal Grape Coccuss (Staphylococcus), the another name for having " thermophilic meat bacterium ", is the representative of gram positive bacteria, can cause many serious Infection.When human body is when skin mucosa injury or low immunity, the dermatosiss that staphylococcus aureuses may cause include hair Capsulitis, furuncle, carbuncle, wound suppuration and abscess etc..
Particularly, for the patient of long-term bed, due to its immunity it is relatively low, it is handicapped, therefore, in its cervical region, waist The positions such as portion, joint are easier to grow the floras such as staphylococcus aureuses, escherichia coli, and at present, some are had on market is used for Antibacterial spray class product is present, but the antibacterial timeliness of spray class product one side is not long, on the other hand easily can be smeared sassafras and be removed It is difficult to long-term reservation.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of antibacterial patch and preparation method thereof, so that above institute is reduced or avoided The problem mentioned.
To solve above-mentioned technical problem, the present invention proposes a kind of antibacterial patch, and which includes fixative and flour bag,
The fixative is made up of following weight raw material：
1.50～5.00g of Radix Sophorae Flavescentiss, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 2.00～5.00g, 1.00～4.00g of Herba Agrimoniae, 1.00～3.00g of Radix Arnebiae (Radix Lithospermi), gold silver Spend 0.50～2.50g, 2.50～6.00g of Caulis et folium gaultheriae yunnanensiss, 1.00～5.00g of Rhizoma Arisaematiss, 0.80～2.80g of Radix Aconiti, Radix Aconiti Kusnezoffii 0.50～2.80,2.50～6.00g of Rhizoma Et Radix Notopterygii, 2.50～6.00g of Radix Angelicae Pubescentiss, 2.50～6.00g of Caulis Spatholobi, 0.50～2.00g of Lignum Sappan, 1.50～4.00g of Lysimachia trientaloides Hemsl., 0.50～2.50g of Herba Asari, 0.50～2.50g of Sanguis Draxonis, 0.50～2.50g of Camphora, Herba Menthae 2.00～ 5.00g, 0.80～2.50g of Myrrha, 2.50～6.00g of Rhizoma Chuanxiong, 0.70～1.50g of indomethacin, chlorhexidine acetate 7.00～ 13.00g, ethanol (60～90%) 1080ml.
The flour bag is made up of following weight raw material：
70.00～100.00g of Radix Gentianae, 50.00～79.00g of Rhizoma Coptidis, 62.00～82.00g of Olibanum, Radix Salviae Miltiorrhizae 160.00～ 200.00g, 160.00～200.00g of Herba Taxilli, 160.00～200.00g of Rhizoma Homalomenae, 80.00～110.00g of Semen Momordicae, osteomiosis Mend 110.00～130.00g, 80.00～110.00g of Radix Notoginseng.
Present invention also offers the preparation method of above-mentioned antibacterial patch, wherein, the fixative preparation method is：
Radix Sophorae Flavescentiss, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Herba Agrimoniae, Radix Arnebiae (Radix Lithospermi), Flos Lonicerae, Caulis et folium gaultheriae yunnanensiss, Rhizoma Arisaematiss, Radix Aconiti, grass are weighed according to above-mentioned formula Aconitum carmichjaelii Debx., Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentiss, Caulis Spatholobi, Lignum Sappan, Lysimachia trientaloides Hemsl., Herba Asari, Sanguis Draxonis, Camphora, Herba Menthae, Myrrha, Rhizoma Chuanxiong, indomethacin, acetic acid Hibitane material, is ground into coarse powder, plus 60～90% ethanol 500ml, extracts more than 48 hours under room temperature, filtration；Medicinal residues again with 60～90% ethanol 500ml, extract more than 48 hours under room temperature, filtration.Merge filtrate twice, add chlorhexidine acetate and indole Mei Xin, stirs, plus 60～90% ethanol to 1080ml, filtration.Filtrate is collected, is obtained final product.
The flour bag preparation method is：According to above-mentioned formula weigh Radix Gentianae, Rhizoma Coptidis, Olibanum, Radix Salviae Miltiorrhizae, Herba Taxilli, thousand Strong, Semen Momordicae, Rhizoma Drynariae, Radix Notoginseng material, crush, sieve, and subpackage is obtained final product.
A kind of antibacterial patch provided by the present invention, can effectively suppress skin surface escherichia coli, staphylococcus aureuses etc. The growth of flora, and have preferable restitution to the skin discomfort that these floras are caused.
Specific embodiment
In order to be more clearly understood to the technical characteristic of the present invention, purpose and effect, now illustrate that the present invention's is concrete Embodiment.
The present invention proposes a kind of antibacterial patch, and which includes fixative and flour bag,
The fixative is made up of following weight raw material：
1.50～5.00g of Radix Sophorae Flavescentiss, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 2.00～5.00g, 1.00～4.00g of Herba Agrimoniae, 1.00～3.00g of Radix Arnebiae (Radix Lithospermi), gold silver Spend 0.50～2.50g, 2.50～6.00g of Caulis et folium gaultheriae yunnanensiss, 1.00～5.00g of Rhizoma Arisaematiss, 0.80～2.80g of Radix Aconiti, Radix Aconiti Kusnezoffii 0.50～2.80,2.50～6.00g of Rhizoma Et Radix Notopterygii, 2.50～6.00g of Radix Angelicae Pubescentiss, 2.50～6.00g of Caulis Spatholobi, 0.50～2.00g of Lignum Sappan, 1.50～4.00g of Lysimachia trientaloides Hemsl., 0.50～2.50g of Herba Asari, 0.50～2.50g of Sanguis Draxonis, 0.50～2.50g of Camphora, Herba Menthae 2.00～ 5.00g, 0.80～2.50g of Myrrha, 2.50～6.00g of Rhizoma Chuanxiong, 0.70～1.50g of indomethacin, chlorhexidine acetate 7.00～ 13.00g, ethanol (60～90%) 1080ml.
The flour bag is made up of following weight raw material：
70.00～100.00g of Radix Gentianae, 50.00～79.00g of Rhizoma Coptidis, 62.00～82.00g of Olibanum, Radix Salviae Miltiorrhizae 160.00～ 200.00g, 160.00～200.00g of Herba Taxilli, 160.00～200.00g of Rhizoma Homalomenae, 80.00～110.00g of Semen Momordicae, osteomiosis Mend 110.00～130.00g, 80.00～110.00g of Radix Notoginseng.
Present invention also offers the preparation method of above-mentioned antibacterial patch, wherein, the fixative preparation method is：
Radix Sophorae Flavescentiss, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Herba Agrimoniae, Radix Arnebiae (Radix Lithospermi), Flos Lonicerae, Caulis et folium gaultheriae yunnanensiss, Rhizoma Arisaematiss, Radix Aconiti, grass are weighed according to above-mentioned formula Aconitum carmichjaelii Debx., Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentiss, Caulis Spatholobi, Lignum Sappan, Lysimachia trientaloides Hemsl., Herba Asari, Sanguis Draxonis, Camphora, Herba Menthae, Myrrha, Rhizoma Chuanxiong, indomethacin, acetic acid Hibitane material, is ground into coarse powder, plus 60～90% ethanol 500ml, extracts more than 48 hours under room temperature, filtration；Medicinal residues again with 60～90% ethanol 500ml, extract more than 48 hours under room temperature, filtration.Merge filtrate twice, add chlorhexidine acetate and indole Mei Xin, stirs, plus 60～90% ethanol to 1080ml, filtration.Filtrate is collected, is obtained final product.
The flour bag preparation method is：According to above-mentioned formula weigh Radix Gentianae, Rhizoma Coptidis, Olibanum, Radix Salviae Miltiorrhizae, Herba Taxilli, thousand Strong, Semen Momordicae, Rhizoma Drynariae, Radix Notoginseng material, crush, sieve, and subpackage is obtained final product.
Embodiment 1
The fixative is made up of following weight raw material：
Radix Sophorae Flavescentiss 1.57g, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 2.34g Herba Agrimoniae 1.25g, Radix Arnebiae (Radix Lithospermi) 1.30g, Flos Lonicerae 0.55g, Caulis et folium gaultheriae yunnanensiss 2.59, Tian Nan Star 1.11g, Radix Aconiti 0.82g, Radix Aconiti Kusnezoffii 0.57, Rhizoma Et Radix Notopterygii 2.68g, Radix Angelicae Pubescentiss 2.58g, Caulis Spatholobi 2.63g, Lignum Sappan 0.55g, chase after wind Umbrella 1.56g, Herba Asari 0.52g, Sanguis Draxonis 0.59g, Camphora 0.51g, Herba Menthae 2.21g, Myrrha 0.84g, Rhizoma Chuanxiong 2.56g, indomethacin 0.72g, chlorhexidine acetate 7.25g, ethanol (65%) 1080ml.
The flour bag is made up of following weight raw material：
Radix Gentianae 72.12g, Rhizoma Coptidis 50.89g, Olibanum 63.00g, Radix Salviae Miltiorrhizae 162.45g, Herba Taxilli 164.15g, Rhizoma Homalomenae 161.3g, Semen Momordicae 80.91g, Rhizoma Drynariae 111.32g, Radix Notoginseng 80.78g.
In present embodiment, the preparation method of antibacterial patch is as follows, and the fixative preparation method is：
Radix Sophorae Flavescentiss, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Herba Agrimoniae, Radix Arnebiae (Radix Lithospermi), Flos Lonicerae, Caulis et folium gaultheriae yunnanensiss, Rhizoma Arisaematiss, Radix Aconiti, grass are weighed according to above-mentioned formula Aconitum carmichjaelii Debx., Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentiss, Caulis Spatholobi, Lignum Sappan, Lysimachia trientaloides Hemsl., Herba Asari, Sanguis Draxonis, Camphora, Herba Menthae, Myrrha, Rhizoma Chuanxiong, indomethacin, acetic acid Hibitane material, is ground into coarse powder, plus 60% ethanol 500ml, extracts more than 48 hours under room temperature, filtration；Medicinal residues are again with 60% Ethanol 500ml, extracts more than 48 hours under room temperature, filtration.Merge filtrate twice, add chlorhexidine acetate and indomethacin, stir Mix uniform, plus 60% ethanol is to 1080ml, filtration.Filtrate is collected, is obtained final product.
The flour bag preparation method is：According to above-mentioned formula weigh Radix Gentianae, Rhizoma Coptidis, Olibanum, Radix Salviae Miltiorrhizae, Herba Taxilli, thousand Strong, Semen Momordicae, Rhizoma Drynariae, Radix Notoginseng material, crush, sieve, and subpackage is obtained final product.
Embodiment 2
The fixative is made up of following weight raw material：
Radix Sophorae Flavescentiss 1.63g, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 3.34g Herba Agrimoniae 2.35g, Radix Arnebiae (Radix Lithospermi) 1.31g, Flos Lonicerae 1.15g, Caulis et folium gaultheriae yunnanensiss 3.59, Tian Nan Star 2.11g, Radix Aconiti 1.42g, Radix Aconiti Kusnezoffii 1.57g, Rhizoma Et Radix Notopterygii 2.68g, Radix Angelicae Pubescentiss 3.58g, Caulis Spatholobi 3.63g, Lignum Sappan 1.27g, chase after Wind umbrella 2.71g, Herba Asari 1.34g, Sanguis Draxonis 0.89g, Camphora 1.23g, Herba Menthae 3.21g, Myrrha 1.64g, Rhizoma Chuanxiong 3.56g, indole are beautiful Pungent 0.92g, chlorhexidine acetate 8.25g, ethanol (70%) 1080ml.
The flour bag is made up of following weight raw material：
Radix Gentianae 77.14g, Rhizoma Coptidis 55.27g, Olibanum 70.91g, Radix Salviae Miltiorrhizae 175.45g, Herba Taxilli 173.98g, Rhizoma Homalomenae 177.81g, Semen Momordicae 85.26g, Rhizoma Drynariae 116.87g, Radix Notoginseng 85.12g.
In present embodiment, the preparation method of antibacterial patch is as follows, and the fixative preparation method is：
Radix Sophorae Flavescentiss, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Herba Agrimoniae, Radix Arnebiae (Radix Lithospermi), Flos Lonicerae, Caulis et folium gaultheriae yunnanensiss, Rhizoma Arisaematiss, Radix Aconiti, grass are weighed according to above-mentioned formula Aconitum carmichjaelii Debx., Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentiss, Caulis Spatholobi, Lignum Sappan, Lysimachia trientaloides Hemsl., Herba Asari, Sanguis Draxonis, Camphora, Herba Menthae, Myrrha, Rhizoma Chuanxiong, indomethacin, acetic acid Hibitane material, is ground into coarse powder, plus 70% ethanol 500ml, extracts more than 48 hours under room temperature, filtration；Medicinal residues are again with 70% Ethanol 500ml, extracts more than 48 hours under room temperature, filtration.Merge filtrate twice, add chlorhexidine acetate and indomethacin, stir Mix uniform, plus 70% ethanol is to 1080ml, filtration.Filtrate is collected, is obtained final product.
The flour bag preparation method is：According to above-mentioned formula weigh Radix Gentianae, Rhizoma Coptidis, Olibanum, Radix Salviae Miltiorrhizae, Herba Taxilli, thousand Strong, Semen Momordicae, Rhizoma Drynariae, Radix Notoginseng material, crush, sieve, and subpackage is obtained final product.
Embodiment 3
The fixative is made up of following weight raw material：
Radix Sophorae Flavescentiss 2.59g, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 3.24g, Herba Agrimoniae 1.94g, Radix Arnebiae (Radix Lithospermi) 1.56g, Flos Lonicerae 1.3g, Caulis et folium gaultheriae yunnanensiss 3.89g, Tian Nan Star 2.59g, Radix Aconiti 1.94g, Radix Aconiti Kusnezoffii 1.94g, Rhizoma Et Radix Notopterygii 3.89g, Radix Angelicae Pubescentiss 3.89g, Caulis Spatholobi 3.89g, Lignum Sappan 1.3g, chase after wind Umbrella 2.59g, Herba Asari 1.3g, Sanguis Draxonis 1.3g, Camphora 1.3g, Herba Menthae 3.11g, Myrrha 1.56g, Rhizoma Chuanxiong 3.89g, indomethacin 1.08g, chlorhexidine acetate 9.18g, ethanol (75%) 1080ml.
The flour bag is made up of following weight raw material：
Radix Gentianae 88.77g, Rhizoma Coptidis 60.48g, Olibanum 72.58g, Radix Salviae Miltiorrhizae 181.44g, Herba Taxilli 181.44g, Rhizoma Homalomenae 181.44g, Semen Momordicae 96.77g, Rhizoma Drynariae 120.31g, Radix Notoginseng 96.77g.
In present embodiment, the preparation method of antibacterial patch is as follows, and the fixative preparation method is：
Radix Sophorae Flavescentiss, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Herba Agrimoniae, Radix Arnebiae (Radix Lithospermi), Flos Lonicerae, Caulis et folium gaultheriae yunnanensiss, Rhizoma Arisaematiss, Radix Aconiti, grass are weighed according to above-mentioned formula Aconitum carmichjaelii Debx., Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentiss, Caulis Spatholobi, Lignum Sappan, Lysimachia trientaloides Hemsl., Herba Asari, Sanguis Draxonis, Camphora, Herba Menthae, Myrrha, Rhizoma Chuanxiong, indomethacin, acetic acid Hibitane material, is ground into coarse powder, plus 75% ethanol 500ml, extracts more than 48 hours under room temperature, filtration；Medicinal residues are again with 75% Ethanol 500ml, extracts more than 48 hours under room temperature, filtration.Merge filtrate twice, add chlorhexidine acetate and indomethacin, stir Mix uniform, plus 75% ethanol is to 1080ml, filtration.Filtrate is collected, is obtained final product.
The flour bag preparation method is：According to above-mentioned formula weigh Radix Gentianae, Rhizoma Coptidis, Olibanum, Radix Salviae Miltiorrhizae, Herba Taxilli, thousand Strong, Semen Momordicae, Rhizoma Drynariae, Radix Notoginseng material, crush, sieve, and subpackage is obtained final product.
Embodiment 4
The fixative is made up of following weight raw material：
Radix Sophorae Flavescentiss 4.87g, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 4.81g, Herba Agrimoniae 3.89g, Radix Arnebiae (Radix Lithospermi) 2.87g, Flos Lonicerae 2.42g, Caulis et folium gaultheriae yunnanensiss 5.89g, day Rhizoma Arisaematis 4.59g, Radix Aconiti 2.70g, Radix Aconiti Kusnezoffii 2.71g, Rhizoma Et Radix Notopterygii 5.72g, Radix Angelicae Pubescentiss 5.82g, Caulis Spatholobi 5.11g, Lignum Sappan 1.91g, Lysimachia trientaloides Hemsl. 3.78g, Herba Asari 2.40g, Sanguis Draxonis 2.38g, Camphora 2.45g, Herba Menthae 4.89g, Myrrha 2.43g, Rhizoma Chuanxiong 5.35g, indole U.S. pungent 1.46g, chlorhexidine acetate 12.98g, ethanol (90%) 1080ml.
The flour bag is made up of following weight raw material：
Radix Gentianae 99.00g, Rhizoma Coptidis 78.47g, Olibanum 81.15g, Radix Salviae Miltiorrhizae 199.49g, Herba Taxilli 199.43g, Rhizoma Homalomenae 199.37g, Semen Momordicae 109.77g, Rhizoma Drynariae 128.56g, Radix Notoginseng 109.89g.
In present embodiment, the preparation method of antibacterial patch is as follows, and the fixative preparation method is：
Radix Sophorae Flavescentiss, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Herba Agrimoniae, Radix Arnebiae (Radix Lithospermi), Flos Lonicerae, Caulis et folium gaultheriae yunnanensiss, Rhizoma Arisaematiss, Radix Aconiti, grass are weighed according to above-mentioned formula Aconitum carmichjaelii Debx., Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentiss, Caulis Spatholobi, Lignum Sappan, Lysimachia trientaloides Hemsl., Herba Asari, Sanguis Draxonis, Camphora, Herba Menthae, Myrrha, Rhizoma Chuanxiong, indomethacin, acetic acid Hibitane material, is ground into coarse powder, plus 90% ethanol 500ml, extracts more than 48 hours under room temperature, filtration；Medicinal residues are again with 90% Ethanol 500ml, extracts more than 48 hours under room temperature, filtration.Merge filtrate twice, add chlorhexidine acetate and indomethacin, stir Mix uniform, plus 90% ethanol is to 1080ml, filtration.Filtrate is collected, is obtained final product.
The flour bag preparation method is：According to above-mentioned formula weigh Radix Gentianae, Rhizoma Coptidis, Olibanum, Radix Salviae Miltiorrhizae, Herba Taxilli, thousand Strong, Semen Momordicae, Rhizoma Drynariae, Radix Notoginseng material, crush, sieve, and subpackage is obtained final product.
When specifically used, the fixative can carry out subpackage according to 2.5ml ± 1ml/ bags.The flour bag can according to 3g ± 1g/ bags carry out subpackage, for the patient of long-term bed, can be by 1 bag of fixative along cutting off, at positions such as its cervical region, waist, joints It is even to be coated on 1 bag of flour bag, it is affixed on corresponding site skin (can assist to fix with medical air-permeable adhesive tape), daily 1-2 patches can have Effect suppresses the growth of the floras such as skin surface escherichia coli, staphylococcus aureuses.
A kind of antibacterial patch provided by the present invention, can effectively suppress skin surface escherichia coli, staphylococcus aureuses etc. The growth of flora, and have preferable restitution to the skin discomfort that these floras are caused.
It will be appreciated by those skilled in the art that although the present invention is described according to the mode of multiple embodiments, It is that not each embodiment only includes an independent technical scheme.For the sake of in description, so narration is used for the purpose of understanding, Those skilled in the art should be understood description as an entirety, and by technical scheme involved in each embodiment Regard as and can be mutually combined into the mode of different embodiments to understand protection scope of the present invention.
Schematically specific embodiment of the invention is the foregoing is only, the scope of the present invention is not limited to.It is any Those skilled in the art, the equivalent variations made on the premise of the design without departing from the present invention and principle, modification and combination, The scope of protection of the invention all should be belonged to.

Claims (2)

1. a kind of antibacterial patch, it is characterised in which includes fixative and flour bag,
The fixative is made up of following weight raw material：
1.50～5.00g of Radix Sophorae Flavescentiss, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 2.00～5.00g, 1.00～4.00g of Herba Agrimoniae, 1.00～3.00g of Radix Arnebiae (Radix Lithospermi), Flos Lonicerae 0.50～2.50g, 2.50～6.00g of Caulis et folium gaultheriae yunnanensiss, 1.00～5.00g of Rhizoma Arisaematiss, 0.80～2.80g of Radix Aconiti, Radix Aconiti Kusnezoffii 0.50 ～2.80,2.50～6.00g of Rhizoma Et Radix Notopterygii, 2.50～6.00g of Radix Angelicae Pubescentiss, 2.50～6.00g of Caulis Spatholobi, 0.50～2.00g of Lignum Sappan, chase after wind 1.50～4.00g of umbrella, 0.50～2.50g of Herba Asari, 0.50～2.50g of Sanguis Draxonis, 0.50～2.50g of Camphora, Herba Menthae 2.00～ 5.00g, 0.80～2.50g of Myrrha, 2.50～6.00g of Rhizoma Chuanxiong, 0.70～1.50g of indomethacin, chlorhexidine acetate 7.00～ 13.00g, ethanol (60～90%) 1080ml.
The flour bag is made up of following weight raw material：
70.00～100.00g of Radix Gentianae, 50.00～79.00g of Rhizoma Coptidis, 62.00～82.00g of Olibanum, Radix Salviae Miltiorrhizae 160.00～ 200.00g, 160.00～200.00g of Herba Taxilli, 160.00～200.00g of Rhizoma Homalomenae, 80.00～110.00g of Semen Momordicae, osteomiosis Mend 110.00～130.00g, 80.00～110.00g of Radix Notoginseng.
2. a kind of preparation method of antibacterial patch according to claim 1, it is characterised in that the fixative preparation method is：
Present invention also offers the preparation method of above-mentioned antibacterial patch, wherein, the fixative preparation method is：
According to above-mentioned formula weigh Radix Sophorae Flavescentiss, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Herba Agrimoniae, Radix Arnebiae (Radix Lithospermi), Flos Lonicerae, Caulis et folium gaultheriae yunnanensiss, Rhizoma Arisaematiss, Radix Aconiti, Radix Aconiti Kusnezoffii, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentiss, Caulis Spatholobi, Lignum Sappan, Lysimachia trientaloides Hemsl., Herba Asari, Sanguis Draxonis, Camphora, Herba Menthae, Myrrha, Rhizoma Chuanxiong, indomethacin, acetic acid chlorine are Earnest material, is ground into coarse powder, plus 60～90% ethanol 500ml, extracts more than 48 hours under room temperature, filtration；Medicinal residues again with 60～ 90% ethanol 500ml, extracts more than 48 hours under room temperature, filtration.Merge filtrate twice, add chlorhexidine acetate and indole beautiful It is pungent, stir, plus 60～90% ethanol to 1080ml, filter.Filtrate is collected, is obtained final product.
The flour bag preparation method is：Radix Gentianae, Rhizoma Coptidis, Olibanum, Radix Salviae Miltiorrhizae, Herba Taxilli, Rhizoma Homalomenae, wood are weighed according to above-mentioned formula Trionyx sinensis Wiegmann, Rhizoma Drynariae, Radix Notoginseng material, crush, sieve, obtain final product.
CN201611048279.6A 2016-11-25 2016-11-25 A kind of antibacterial patch and preparation method thereof Pending CN106540024A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112321479A (en) * 2020-11-04 2021-02-05 吉林大学 Indole-4-formaldehyde compound with antibacterial activity in parasitic loranthus, preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1745802A (en) * 2005-09-01 2006-03-15 岑容名 Plaster for treating pain and prpearation thereof

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
CN1745802A (en) * 2005-09-01 2006-03-15 岑容名 Plaster for treating pain and prpearation thereof

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Title
沈宝亨: "《应用药物制剂技术》", 31 December 2000, 中国医药科技出版社 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112321479A (en) * 2020-11-04 2021-02-05 吉林大学 Indole-4-formaldehyde compound with antibacterial activity in parasitic loranthus, preparation method and application thereof
CN112321479B (en) * 2020-11-04 2022-02-08 吉林大学 Indole-4-formaldehyde compound with antibacterial activity in parasitic loranthus, preparation method and application thereof

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Application publication date: 20170329