CN106539863A - One kind prevents and treats osteoporosis capsule preparation method thereof - Google Patents
One kind prevents and treats osteoporosis capsule preparation method thereof Download PDFInfo
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- CN106539863A CN106539863A CN201510610182.9A CN201510610182A CN106539863A CN 106539863 A CN106539863 A CN 106539863A CN 201510610182 A CN201510610182 A CN 201510610182A CN 106539863 A CN106539863 A CN 106539863A
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Abstract
The present invention relates to one kind prevents and treats osteoporosis capsule preparation method thereof, product of the present invention is made up of the main material of following weight portion meter:450 parts of barrenwort, 360 parts of Psoralea corylifolia, 300 parts of the red sage root, 270 parts of the Radix Astragali, 270 parts of zaocys dhumnade;Take that above raw material is extracted, concentrate, be dried, crush, being processed into and possess the Chinese medicinal capsule for increasing bone density, compare and existing prevent and treat osteoporosis medicament, this product pure Chinese medicine formula is formed, the absorption for promoting most calcium by adjusting endocrine prevents and treats osteoporosis medicament, and stable preparation process, reliability so as to reach the one kind for increasing bone density.
Description
Technical field
The present invention relates to a kind of preparation method of medicament, specially one kind prevent and treat osteoporosis capsule preparation method thereof.
Background technology
Osteoporosis is a kind of metabolic bone disease of whole body, shows as the density and Quality Down of bone, causes bone fragile, is susceptible to fracture, especially the fracture at the position such as lumbar vertebrae, hip and wrist.
According to the data of the World Health Organization, osteoporosis is global health problem, and its seriousness is only second to cardiovascular disease, is threatened more than common diseases such as breast cancer, prostate cancers.In global more than 50 years old old man, 1/3 women and 1/5 male sex can be threatened by osteoporosis, according to incompletely statistics, China's senile osteoporosis disease incidence of disease of more than 60 years old is about 59.89%, increase the important topic that bone density, effectively treatment osteoporosis have become people's extensive concern, and " patent " of osteoporosis non-senile, if ignoring motion at an early age, dietary structure is unbalanced, cause the intake of dietary calcium few, preferable bone peak volume and quality are not reached, just has osteoporotic danger.
Modern medicine study proves, no matter men and women, if bone health growth, bone most strong period is 20-40 year, that is the period bone has reached highest bone amount and best quality, and whether bone can reach best condition, relevant with h and E factor etc..Once and spent 40 years old, the speed of bone-loss has just exceeded the speed for being formed, and bone amount begins to decline, sclerotin gradually becomes fragile, and as the age increases gradually, suffers from osteoporotic possibility and also increases, so the women of more than 50 years old, has half that relevant fracture of osteoporosis can occur for the rest of one's life.
Osteoporosis is used as common disease and frequently-occurring disease, it is wide which is related to crowd's scope, number is more, it is larger to health hazard, therefore developing the osteoporotic health products of prevention has very wide market prospects, Western medicine treating that osteoporosis symptoms directions toxic side effect is big, late result is not affirmed, it is expensive the shortcomings of, the medicine law that traditional Chinese medicine has which unique, which has original advantage in anti-curing osteoporosis, the health products of increase bone density in the market, how in the majority in the form of direct supplement calcium, its osteoporotic effect of preventing and treating is unsatisfactory.
The content of the invention
Present invention aim to provide a kind of pure Chinese medicine formula form, the absorption for promoting most calcium by adjusting endocrine prevents and treats osteoporosis capsule preparation method thereof so as to reach the one kind for increasing bone density.
For achieving the above object, the technical solution used in the present invention is:
One kind prevents and treats osteoporosis capsule, is made up of the main material of following weight portion meter:450 parts of barrenwort, 360 parts of Psoralea corylifolia, 300 parts of the red sage root, 270 parts of the Radix Astragali, 270 parts of zaocys dhumnade.
One kind prevents and treats osteoporosis capsule preparation method thereof:/ 5th amounts of red sage root total amount are taken, is crushed as fine powder, crossed 100 mesh sieves, obtain red sage root fine powder standby;It is fragment to take zaocys dhumnade and crush, standby;Take the remaining red sage root, the Radix Astragali, barrenwort, Psoralea corylifolia, zaocys dhumnade fragment mixing and water adding to decoct twice, the water of its 12 times of weight of total amount is added for the first time, decoct 2 hours, add the water of its 10 times of weight for the second time, decoct 1.5 hours, filtration, above-mentioned filtrate is placed in hot reflux extracting-concentration machine group, vacuum 0.06Mpa by merging filtrate, pressure 0.02-0.04Mpa, filtrate are evaporated to the thick paste that relative density is 1.25-1.30 at 60 DEG C;Thick paste is placed in constant pressure and dry case, is dried at 90 DEG C, crushed 80 mesh sieves, get dry extract powder;Standby red sage root fine powder is merged with dried cream powder, is well mixed, cross 80 mesh sieves, added customary adjuvant, make required formulation.
During producing capsule, above-mentioned forming steps, drying are taken to get dry extract after powder, standby danshen powder, dried cream powder and appropriate amount of starch are well mixed, with 95% medicinal alcohol as wetting agent, softwood processed crosses the granulation of 20 eye mesh screens, obtain wet granular, at 60 DEG C, constant pressure and dry obtains dry particl, crosses 24 eye mesh screen whole grains, adds 0.5% medicinal magnesium stearate, it is well mixed, it is filling encapsulated.
This Chinese medicine preparation choice requirement:Barrenwort net system requires to remove thick stalk and impurity, dries, processes and require:Impurity is removed, blade is won, clear water is sprayed, is slightly moistened, chopping, be dried;Psoralea corylifolia net system requires to remove impurity, processes and requires:Stir-baked SEMEN PSORALEAE with salt solution, takes net Psoralea corylifolia, fries to micro- according to the salt solution method of processing and heaves;The red sage root removes silt, is dried, and processes and requires:Impurity and stubble are removed, is cleaned and is run through, cut sheet, be dried;Radix Astragali net system requires to remove fibrous root and root head, dries, and processing requires out decontamination, and size is separate, cleans and runs through, and cuts sheet drying;Zaocys dhumnade net system requires to cast aside belly, removes internal organ, is coiled into the shape of a disc, and is dried, and processes and requires, wine zaocys dhumnade takes net zaocys dhumnade section, processs method fried dry according to wine.
The efficacy effect of this formula of Chinese materia medica preparation raw material:
Barrenwort:Acrid, sweet, warm.Return liver and kidney channel.The effect of with kidney-replenishing, strengthening the bones and muscles, wines used as antirheumatic.For impotence and seminal emission, muscles and bones impotence, arthralgia due to wind-dampness, numbness contracture;Climacteric hypertension, the extract of barrenwort have the activity for suppressing osteoclast, while and promote function of osteoblast, increase calcification bon e formation, bon e formation is more than bone information.
Psoralea corylifolia:Taste is pungent;It is bitter;It is warm in nature.Return kidney;Pericardium;Spleen;Stomach;Lung channel.With tonifying the kidney and support yang;Gas of receiving is relievingd asthma;Warming spleen and stopping diarrha the effect of.The main insufficiency of the kidney yang;Below element deficiency and cold;Waist and knee crymodynia;Impotence and seminal emission;Frequent micturition;The enuresis;The failure of the kidney in receiving air;Void is breathed heavily incessantly;Speen-kidney dificiency;Stool chronic diarrhea;Leucoderma;Alopecia areata;Psoriasis.Psoralea corylifolia contains various active composition, such as Coumarins, flavonoids etc., with the effect for suppressing bone information promoting bone growing.
The red sage root:Hardship, is slightly cold.The thoughts of returning home, Liver Channel.With the effect of promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, cool blood to disappear carbuncle, relieving restlessness that clears away heart-fire, nourishing blood and tranquilization.Cure mainly irregular menstruation, Amenorrhea dysmenorrhoea, a lump in the abdomen causing distension and pain, chest and abdomen shouting pain, hot numbness pain, sore swell and ache curative, dysphoria and insomnia;Hepatosplenomegaly, angina pectoris.Red sage root common medicine promoting blood circulation and removing blood stasis, tanshinone have suppression bone information and reduce bone conversion ratio, delay or block the effect of the quick bone loss of post menopausal.
The Radix Astragali:Nature and flavor:It is sweet, tepor.Return through:Return lung, spleen, liver and kidney channel.The effect of with invigorating qi for consolidating superficies, arrest sweating admittedly take off, torr sore myogenic, inducing diuresis for removing edema.For treating treatment deficiency of vital energy weak, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, ulcer is difficult to burst, bursts for a long time and does not holds back, blood deficiency chlorosis, Heat Diabetes, chronic nephritis, albuminuria, diabetes etc..Astragalus flavonid extract improves significantly sclerotin, increases the impaired effect of bone density, preventing and treating reproductive organs.
Zaocys dhumnade:It is sweet, put down.Return liver warp.With wind-dispelling, dredging collateral, only the effect of convulsion.For rheumatoid arthritis stubborn, numbness contracture, apoplexy facial paralysis, hemiplegia, tic spasm, lockjaw, leprosy mange, scrofula dislike sore.Zaocys dhumnade contains rich in protein, amino acid needed by human and various trace elements, searches wind with deep, the effect of dredging collateral work(poison.
The formulation of this Chinese medicine preparation chooses capsule, and capsule is not only clean and tidy, attractive in appearance, easily swallow, and cuts the bad smell that can cover medicine, and the bioavilability of medicine is high, easily absorbs, and medicine stability is good.
In prescription, the aqueous extract of ingredients has the osteoporotic effect of preventing and treating, for Simplified flowsheet, save production cost, determine that barrenwort in prescription, Psoralea corylifolia, the red sage root, the Radix Astragali, zaocys dhumnade are extracted with water, for cost-effective, the hygroscopicity of dried cream powder is reduced simultaneously, therefore a part of red sage root is crushed as auxiliary material and is added.
Experiments verify that, production technology is extracted using water twice, effective component extraction rate reaches more than 90%, substantially by significant constituents extraction completely, while considering energy saving, reduces cost, select twice;Add water the selection of dosage and decocting time, then beneficial to energy saving, reducing energy consumption;The mode of selection reduced pressure concentration concentrates the reservation beneficial to active ingredient, and then through experiment, checking draws repeatedly for the selection of each parameter of concentration condition, and smoothly, without boiling explosion phenomenon, thickening efficiency is high for experimental result concentration.
This Chinese medicine preparation is formed with the pure Chinese medicine composition of raw materials such as barrenwort, Psoralea corylifolia, the red sage root, the Radix Astragali, zaocys dhumnade, and wherein barrenwort, Psoralea corylifolia is monarch drug in a prescription, and kidney-replenishing, warm spleen sun, replenishing kidney and strengthening bone, controlling nocturnal emission with astringent drugs fill out marrow, and the kidney being the origin of congenital constitution, the spleen being the foundation of acquired constitution.Kidney yang is prosperous, and spleen sun is contained.Then vital essence foot, muscles and bones are good for, and muscle is strong.The Radix Astragali, red sage root tonifying Qi and lifting yang, promoting blood circulation and removing blood stasis for minister, spleen and lung gas is prosperous, and the stasis of blood stagnantization disappears, you can principal drug assistance metaplasia essence and blood, promotes the operation of whole body qi and blood, again can warming meridian, the dissipation stasis of blood is stagnant, damp-clearing pain-relieving.Assistant zaocys dhumnade wind-dispelling, dredging collateral, determine convulsion, tonification and purgation in combination makes benefit and not stagnant, the effect of enhancing disperse blood stasis and dredge collateral pain relieving.All medicine phases are closed, and are tonified the liver and kidney, and beneficial gas controlling nocturnal emission with astringent drugs strengthens muscles and bones, and silt releasing and analgesia is treated both principal and secondary aspect of disease.Compare existing preventing and treating medicine for treating osteoporosis, this Chinese medicine preparation is to tonify the liver and kidney, blood-nourishing production of sperm, strengthen muscles and bones based on, assistant with promoting blood circulation, remove obstruction in channels to relieve pain, dispelling wind and eliminating dampness is as principle, to improve bone density, suppress bone information, reduce bone loss, it is so as to reach the osteoporotic purpose of preventing and treating and stable preparation process, feasible, controllable, it is adaptable to big to produce.
Specific embodiment
Embodiment 3:A kind of Chinese medicine preparation for preventing and treating osteoporosis, is made up of the main material of following weight portion meter:450 parts of barrenwort, 360 parts of Psoralea corylifolia, 300 parts of the red sage root, 270 parts of the Radix Astragali, 270 parts of zaocys dhumnade.
Said ratio raw material is taken, a kind of preparation method of the Chinese medicine preparation for preventing and treating osteoporosis is:60 parts of the red sage root is taken, is crushed as fine powder, crossed 100 mesh sieves, obtain red sage root fine powder standby;It is fragment to take zaocys dhumnade and crush, standby;Take the remaining red sage root, the Radix Astragali, barrenwort, Psoralea corylifolia, zaocys dhumnade fragment mixing and water adding to decoct twice, the water of its 12 times of weight of total amount is added for the first time, decoct 2 hours, add the water of its 10 times of weight for the second time, decoct 1.5 hours, filtration, above-mentioned filtrate is placed in hot reflux extracting-concentration machine group, vacuum 0.06Mpa by merging filtrate, pressure 0.04Mpa, filtrate are evaporated to the thick paste that relative density is 1.30 at 60 DEG C;Thick paste is placed in constant pressure and dry case, is dried at 90 DEG C, crushed 80 mesh sieves, get dry extract powder;Standby danshen powder, dried cream powder and starch are well mixed, with 95% medicinal alcohol as wetting agent, softwood processed crosses the granulation of 20 eye mesh screens, obtain wet granular, at 60 DEG C, constant pressure and dry obtains dry particl, crosses 24 eye mesh screen whole grains, adds 0.5% medicinal magnesium stearate, it is well mixed, filling encapsulated, the present embodiment selects capsule, with advantages below:Bad smell can be covered;Compared with tablet, pill, it is not required to during preparation plus adhesive and big pressure, absorption of human body is fast;Medicine lucifuge, sealing, the property of medicine are stable;Content homogeneity is good, and content deviation is low.
Claims (2)
1. one kind prevents and treats osteoporosis capsule preparation method thereof, it is characterized in that:Prevent and treat osteoporosis capsule to be made up of the main material of following weight portion meter:450 parts of barrenwort, 360 parts of Psoralea corylifolia, 300 parts of the red sage root, 270 parts of the Radix Astragali, 270 parts of zaocys dhumnade;:/ 5th amounts of red sage root total amount are taken, is crushed as fine powder, crossed 100 mesh sieves, obtain red sage root fine powder standby;It is fragment to take zaocys dhumnade and crush, standby;Take the remaining red sage root, the Radix Astragali, barrenwort, Psoralea corylifolia, zaocys dhumnade fragment mixing and water adding to decoct twice, the water of its 12 times of weight of total amount is added for the first time, decoct 2 hours, add the water of its 10 times of weight for the second time, decoct 1.5 hours, filtration, above-mentioned filtrate is placed in hot reflux extracting-concentration machine group, vacuum 0.06Mpa by merging filtrate, pressure 0.02-0.04Mpa, filtrate are evaporated to the thick paste that relative density is 1.25-1.30 at 60 DEG C;Thick paste is placed in constant pressure and dry case, is dried at 90 DEG C, crushed 80 mesh sieves, get dry extract powder;Standby red sage root fine powder is merged with dried cream powder, is well mixed, cross 80 mesh sieves, added customary adjuvant, make required formulation.
2. osteoporosis capsule preparation method thereof is prevented and treated, be it is characterized in that:During producing capsule, above-mentioned forming steps, drying are taken to get dry extract after powder, standby danshen powder, dried cream powder and appropriate amount of starch are well mixed, with 95% medicinal alcohol as wetting agent, softwood processed crosses the granulation of 20 eye mesh screens, obtain wet granular, at 60 DEG C, constant pressure and dry obtains dry particl, crosses 24 eye mesh screen whole grains, adds 0.5% medicinal magnesium stearate, it is well mixed, it is filling encapsulated.
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