CN105560368A - Preparation method for capsule used for preventing and treating osteoporosis - Google Patents
Preparation method for capsule used for preventing and treating osteoporosis Download PDFInfo
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- CN105560368A CN105560368A CN201410538066.6A CN201410538066A CN105560368A CN 105560368 A CN105560368 A CN 105560368A CN 201410538066 A CN201410538066 A CN 201410538066A CN 105560368 A CN105560368 A CN 105560368A
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Abstract
The invention relates to a preparation method for a capsule used for preventing and treating osteoporosis. The capsule comprises the following main raw materials by weight: 450 parts of epimedium, 360 parts of Psoralea corylifolia, 300 parts of red sage root, 270 parts of Radix Astragali and 270 parts of Zaocys dhumnades. The traditional Chinese medicine capsule capable of increasing bone mineral density is prepared through extraction, concentration, drying, crushing and processing. Compared with conventional drugs used for preventing and treating osteoporosis, the capsule provided by the invention has the following advantages: the capsule is prepared according to a pure traditional Chinese medicine formula; endocrine is adjusted so as to promote absorption of calcium, so the purpose of increasing bone mineral density is achieved; and the preparation method is stable and reliable.
Description
Technical field
The present invention relates to a kind of preparation method of medicament, be specially one and prevent and treat osteoporosis capsule preparation method thereof.
Background technology
Osteoporosis is a kind of metabolic bone disease of whole body, shows as density and the Quality Down of skeleton, causes skeleton fragile, easily fractures, especially the fracture at the position such as lumbar vertebra, hip and wrist.
According to the data of World Health Organization (WHO), osteoporosis is global health problem, and its seriousness is only second to cardiovascular diseases, threatens and is greater than the common disease such as breast carcinoma, carcinoma of prostate.In more than the 50 years old old man in the whole world, the women of 1/3 and the male of 1/5 can be subject to osteoporosis and threaten, according to incompletely statistics, the senile osteoporosis disease sickness rate of China more than 60 years old is about 59.89%, increase bone density, effectively treatment osteoporosis and become the important topic of people's extensive concern, and osteoporosis " patent " of non-senile, if ignore motion at an early age, dietary structure is unbalanced, cause the absorption of dietary calcium few, do not reach desirable skeleton peak volume and quality, just have osteoporotic danger.
Modern medicine study proves, no matter men and women, if bone health growth, skeleton the most strong period is 20-40 year, that is this, skeleton reached the highest bone amount and best quality in period, and whether skeleton can reach best condition, relevant with h and E factor etc.And once spend 40 years old, the speed of bone-loss has just exceeded the speed formed, bone amount starts to decline, sclerotin becomes fragile gradually, along with the age increases gradually, suffer from osteoporotic probability also to increase, so the women of more than 50 years old, have half that the relevant fracture of osteoporosis can occur for the rest of one's life.
Osteoporosis is as commonly encountered diseases and frequently-occurring disease, it is wide that it relates to crowd's scope, number is many, larger to health hazard, therefore the health product developing prevention of osteoporosis have very wide market prospect, the shortcomings such as Western medicine is large at treatment osteoporosis symptoms direction toxic side effect, late result is not affirmed, expensive, Chinese medicine has the medicine law of its uniqueness, it has original advantage in protect against osteoporosis, the health product of increase bone density in the market, form mainly with direct supplement calcium is in the majority, and it is unsatisfactory that it prevents and treats osteoporotic effect.
Summary of the invention
Object of the present invention will provide a kind of pure Chinese medicine formula to form exactly, by adjustment endocrine short calcium to the greatest extent absorption thus reach the one increasing bone density and prevent and treat osteoporosis capsule preparation method thereof.
For achieving the above object, the technical solution used in the present invention is:
One prevents and treats osteoporosis capsule, is made up of the main material of following parts by weight: Herba Epimedii 450 parts, Fructus Psoraleae 360 parts, Radix Salviae Miltiorrhizae 300 parts, the Radix Astragali 270 parts, Zaocys 270 parts.
One prevents and treats osteoporosis capsule preparation method thereof: 1/5th amounts of getting Radix Salviae Miltiorrhizae total amount, pulverizes as fine powder, crosses 100 mesh sieves, obtains Radix Salviae Miltiorrhizae fine powder for subsequent use; Getting Zaocys pulverizes as fragment, for subsequent use; Get remaining Radix Salviae Miltiorrhizae, the Radix Astragali, Herba Epimedii, Fructus Psoraleae, Zaocys fragment mixing and water adding decoct twice, add the water of its total amount 12 times of weight for the first time, decoct 2 hours, second time adds the water of its 10 times of weight, decocts 1.5 hours, filter, merging filtrate, is placed in hot reflux extracting-concentration machine group by above-mentioned filtrate, vacuum 0.06Mpa, pressure 0.02-0.04Mpa, filtrate is evaporated to the thick paste that relative density is 1.25-1.30 at 60 DEG C; Thick paste is placed in constant pressure and dry case, carry out at 90 DEG C dry, pulverize 80 mesh sieves, get dry extract powder; Radix Salviae Miltiorrhizae fine powder for subsequent use and dried cream powder are merged, mix homogeneously, cross 80 mesh sieves, add customary adjuvant, make required dosage form.
Produce in the process of capsule, take above-mentioned forming steps, drying gets dry extract after powder, by Radix Salviae Miltiorrhizae powder for subsequent use, dried cream powder and appropriate amount of starch mix homogeneously, with 95% medicinal alcohol as wetting agent, soft material processed, crosses 20 eye mesh screens and granulates, obtain wet granular, at 60 DEG C, constant pressure and dry must do granule, crosses 24 eye mesh screen granulate, adds 0.5% medicinal magnesium stearate, mix homogeneously, fill is encapsulated.
This Chinese medicine preparation choice requirement: Herba Epimedii is only made and required the thick stalk of removing and impurity, and dry, concoct and require: removing impurity, win blade, spray clear water, slightly moistens, shredding, dry; Fructus Psoraleae is only made and is required removing impurity, concocts and requires: stir-baked SEMEN PSORALEAE with salt solution, get clean Fructus Psoraleae, fries heave to micro-according to saline method of processing; Radix Salviae Miltiorrhizae removing silt, dry, concoct and require: removing impurity and stubble, clean and run through, cut sheet, dry; The Radix Astragali is only made and is required removing fibrous root and root head, dries, and concocts and requires out decontamination, and size separately, is cleaned and run through, cut sheet drying; Zaocys only requirement processed casts aside abdominal part, and removing internal organs, coil into discoid, dry, and concoct requirement, wine Zaocys, gets clean Zaocys section, process method fried dry according to wine.
The efficacy effect of this formula of Chinese materia medica preparation raw material:
Herba Epimedii: acrid, sweet, warm.Return liver, kidney channel.There is kidney-replenishing, bone and muscle strengthening, effect of wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension, the extracting solution of Herba Epimedii has the activity suppressing osteoclast, promotes function of osteoblast again simultaneously, and calcified bone is formed to be increased, and bone formation is greater than bone resorption.
Fructus Psoraleae: acrid in the mouth; Bitter; Warm in nature.Return kidney; Pericardium; Spleen; Stomach; Lung meridian.There is reinforcing the kidney and supporting YANG; Helping inspiration to relieve asthma; Warming spleen and stopping diarrha effect.Main insufficiency of kidney-YANG; Below element deficiency and cold; Chills and pain of the waist and kness; Impotence and seminal emission; Frequent micturition; The enuresis; Failure of the kidney in receiving QI; Dyspnea due to deficiency is more than; Asthenia of both the spleen and kidney; Stool chronic diarrhea; Vitiligo; Speckle is bald; Psoriasis.Fructus Psoraleae contains various active composition, as Coumarins, flavonoid etc., has the effect suppressing bone resorption promoting bone growing.
Radix Salviae Miltiorrhizae: bitter, is slightly cold.GUIXIN, Liver Channel.Have promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, effect of nourishing blood to tranquillize the mind.Cure mainly menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling common medicine, TANSHINONES has suppression bone resorption and reduces bone conversion ratio, delays or block the effect of the quick bone loss of post menopausal.
The Radix Astragali: nature and flavor: sweet, tepor.Gui Jing: return lung, spleen, liver, kidney channel.There is effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.Be used for the treatment of the deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.Radix Astragali total flavones extract improves significantly sclerotin, increases the effect that bone density, control genitals are impaired.
Zaocys: sweet is flat.Return Liver Channel.Have and dispel the wind, dredging collateral, effect of relieving convulsion.For rheumatoid arthritis stubborn, numbness contracture, apoplexy facial hemiparalysis, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.Zaocys contains rich in protein, the aminoacid of needed by human and various trace elements, has deeply to search wind, effect of dredging collateral merit poison.
The dosage form of this Chinese medicine preparation chooses capsule, capsule not only clean and tidy, attractive in appearance, easily swallow, cut the bad smell can covering medicine, the bioavailability of medicine is high, easily absorbs, and medicine stability is good.
In prescription, the aqueous extract of ingredients all has the osteoporotic effect of control, in order to Simplified flowsheet, save production cost, determine Herba Epimedii in prescription, Fructus Psoraleae, Radix Salviae Miltiorrhizae, the Radix Astragali, Zaocys water extraction, for cost-saving, reduce the hygroscopicity of dried cream powder simultaneously, therefore a part of Radix Salviae Miltiorrhizae pulverizing is added as adjuvant.
Through experimental verification, production technology adopts twice water extraction, and effective component extraction rate reaches more than 90%, substantially that significant constituents extraction is complete, considers energy savings simultaneously, reduces costs, select twice; Add water the choosing of dosage and decocting time, be then beneficial to energy savings, reduce energy consumption; The mode choosing concentrating under reduced pressure concentrates the reservation being beneficial to effective ingredient, choosing of the concentrated each parameter of condition, and repeatedly verify through experiment and draw, experimental result is smoothly concentrated, and without boiling explosion phenomenon, thickening efficiency is high.
This Chinese medicine preparation forms with pure raw material of Chinese medicine formula such as Herba Epimedii, Fructus Psoraleae, Radix Salviae Miltiorrhizae, the Radix Astragali, Zaocyss, and wherein Herba Epimedii, Fructus Psoraleae are monarch drug, and kidney-replenishing, warming the spleen sun, replenishing kidney and strengthening bone, marrow filled out by controlling nocturnal emission with astringent drugs, and the kidney being the origin of congenital constitution, the spleen being the foundation of acquired constitution.Kidney yang is prosperous, the spleen excess of YANG.Then vital essence foot, muscles and bones is good for, and muscle is strong.The Radix Astragali, Radix Salviae Miltiorrhizae tonifying Qi and lifting yang, blood circulation promoting and blood stasis dispelling is minister, and spleen lung qi is prosperous, and the stasis of blood stagnantization disappears, can principal drug assistance promoting generation of vital essence and blood, promotes the operation of whole body QI and blood, again can promoting the flow of QI-blood by warming the meridian, and the dissipation stasis of blood is stagnant, damp-clearing pain-relieving.Assistant Zaocys dispels the wind, dredging collateral, determine convulsion, reinforcing and reducing concurrently, makes tonify without causing stagnation, the effect of enhancing disperse blood stasis and dredge collateral pain relieving.All medicines are harmonious, liver and kidney tonifying, QI invigorating controlling nocturnal emission with astringent drugs, bone and muscle strengthening, silt releasing and analgesia, treating both the principal and secondary aspects of a disease.Compare existing control medicine for treating osteoporosis, this Chinese medicine preparation is based on liver and kidney tonifying, the spermatogenesis that nourishes blood, bone and muscle strengthening, help with blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, expelling wind and removing dampness as principle, in order to improve bone density, suppress bone resorption, reduce bone loss, thus reach the osteoporotic object of control, and stable preparation process, feasible, controlled, be applicable to large production.
Detailed description of the invention
Embodiment 3: a kind of Chinese medicine preparation preventing and treating osteoporosis, is made up of the main material of following parts by weight: Herba Epimedii 450 parts, Fructus Psoraleae 360 parts, Radix Salviae Miltiorrhizae 300 parts, the Radix Astragali 270 parts, Zaocys 270 parts.
Get said ratio raw material, a kind of preparation method of preventing and treating the Chinese medicine preparation of osteoporosis is: get Radix Salviae Miltiorrhizae 60 parts, pulverizes as fine powder, crosses 100 mesh sieves, obtains Radix Salviae Miltiorrhizae fine powder for subsequent use; Getting Zaocys pulverizes as fragment, for subsequent use; Get remaining Radix Salviae Miltiorrhizae, the Radix Astragali, Herba Epimedii, Fructus Psoraleae, Zaocys fragment mixing and water adding decoct twice, add the water of its total amount 12 times of weight for the first time, decoct 2 hours, second time adds the water of its 10 times of weight, decocts 1.5 hours, filter, merging filtrate, is placed in hot reflux extracting-concentration machine group by above-mentioned filtrate, vacuum 0.06Mpa, pressure 0.04Mpa, filtrate is evaporated to the thick paste that relative density is 1.30 at 60 DEG C; Thick paste is placed in constant pressure and dry case, carry out at 90 DEG C dry, pulverize 80 mesh sieves, get dry extract powder; By Radix Salviae Miltiorrhizae powder for subsequent use, dried cream powder and starch mix homogeneously, with 95% medicinal alcohol as wetting agent, soft material processed, crosses 20 eye mesh screens and granulates, obtain wet granular, at 60 DEG C, constant pressure and dry must do granule, crosses 24 eye mesh screen granulate, adds 0.5% medicinal magnesium stearate, mix homogeneously, fill is encapsulated, and the present embodiment selects capsule, has the following advantages: can cover bad smell; Compared with tablet, pill, do not need during preparation to add binding agent and large pressure, absorption of human body is fast; Medicine lucifuge, sealing, the property of medicine is stablized; Content homogeneity is good, and content deviation is low.
Claims (2)
1. prevent and treat an osteoporosis capsule preparation method thereof, it is characterized in that: prevent and treat osteoporosis capsule and be made up of the main material of following parts by weight: Herba Epimedii 450 parts, Fructus Psoraleae 360 parts, Radix Salviae Miltiorrhizae 300 parts, the Radix Astragali 270 parts, Zaocys 270 parts; : 1/5th amounts of getting Radix Salviae Miltiorrhizae total amount, pulverize as fine powder, cross 100 mesh sieves, obtain Radix Salviae Miltiorrhizae fine powder for subsequent use; Getting Zaocys pulverizes as fragment, for subsequent use; Get remaining Radix Salviae Miltiorrhizae, the Radix Astragali, Herba Epimedii, Fructus Psoraleae, Zaocys fragment mixing and water adding decoct twice, add the water of its total amount 12 times of weight for the first time, decoct 2 hours, second time adds the water of its 10 times of weight, decocts 1.5 hours, filter, merging filtrate, is placed in hot reflux extracting-concentration machine group by above-mentioned filtrate, vacuum 0.06Mpa, pressure 0.02-0.04Mpa, filtrate is evaporated to the thick paste that relative density is 1.25-1.30 at 60 DEG C; Thick paste is placed in constant pressure and dry case, carry out at 90 DEG C dry, pulverize 80 mesh sieves, get dry extract powder; Radix Salviae Miltiorrhizae fine powder for subsequent use and dried cream powder are merged, mix homogeneously, cross 80 mesh sieves, add customary adjuvant, make required dosage form.
2. prevent and treat osteoporosis capsule preparation method thereof, it is characterized in that: produce in the process of capsule, take above-mentioned forming steps, drying gets dry extract after powder, by Radix Salviae Miltiorrhizae powder for subsequent use, dried cream powder and appropriate amount of starch mix homogeneously, with 95% medicinal alcohol as wetting agent, soft material processed, cross 20 eye mesh screens to granulate, obtain wet granular, at 60 DEG C, constant pressure and dry must do granule, cross 24 eye mesh screen granulate, add 0.5% medicinal magnesium stearate, mix homogeneously, fill is encapsulated.
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Application publication date: 20160511 |