CN106511153A - 一种具有祛痘功效的纳米组合物及其化妆品或护肤品 - Google Patents
一种具有祛痘功效的纳米组合物及其化妆品或护肤品 Download PDFInfo
- Publication number
- CN106511153A CN106511153A CN201610937380.0A CN201610937380A CN106511153A CN 106511153 A CN106511153 A CN 106511153A CN 201610937380 A CN201610937380 A CN 201610937380A CN 106511153 A CN106511153 A CN 106511153A
- Authority
- CN
- China
- Prior art keywords
- acne
- cosmetics
- composition
- skin care
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010000496 acne Diseases 0.000 title claims abstract description 76
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 74
- 239000000203 mixture Substances 0.000 title claims abstract description 43
- 239000002537 cosmetic Substances 0.000 title claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 102000011782 Keratins Human genes 0.000 claims abstract description 20
- 108010076876 Keratins Proteins 0.000 claims abstract description 20
- 150000001413 amino acids Chemical class 0.000 claims abstract description 20
- 239000001905 cichorium intybus l. root extract Substances 0.000 claims abstract description 19
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229960003237 betaine Drugs 0.000 claims abstract description 18
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 31
- 238000002360 preparation method Methods 0.000 claims description 17
- 239000000839 emulsion Substances 0.000 claims description 15
- 239000007908 nanoemulsion Substances 0.000 claims description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- 239000008367 deionised water Substances 0.000 claims description 11
- 229910021641 deionized water Inorganic materials 0.000 claims description 11
- 239000002245 particle Substances 0.000 claims description 11
- 239000007864 aqueous solution Substances 0.000 claims description 10
- 239000003921 oil Substances 0.000 claims description 10
- 235000014593 oils and fats Nutrition 0.000 claims description 10
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 8
- 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 claims description 7
- 239000002562 thickening agent Substances 0.000 claims description 7
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000003755 preservative agent Substances 0.000 claims description 6
- 230000002335 preservative effect Effects 0.000 claims description 6
- 239000000080 wetting agent Substances 0.000 claims description 6
- BVTHRGZMQHOCOL-UHFFFAOYSA-N OCC(O)(C1(NC(=O)NCNC(=O)NC2(CO)NC(=O)NC2=O)NC(=O)NC1=O)CO Chemical compound OCC(O)(C1(NC(=O)NCNC(=O)NC2(CO)NC(=O)NC2=O)NC(=O)NC1=O)CO BVTHRGZMQHOCOL-UHFFFAOYSA-N 0.000 claims description 5
- 238000009826 distribution Methods 0.000 claims description 5
- 238000005292 vacuum distillation Methods 0.000 claims description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 4
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 4
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 150000001298 alcohols Chemical class 0.000 claims description 4
- 238000001704 evaporation Methods 0.000 claims description 4
- 230000008020 evaporation Effects 0.000 claims description 4
- 239000012467 final product Substances 0.000 claims description 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 4
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims description 4
- 239000000787 lecithin Substances 0.000 claims description 4
- 235000010445 lecithin Nutrition 0.000 claims description 4
- 229940067606 lecithin Drugs 0.000 claims description 4
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 4
- 229940083466 soybean lecithin Drugs 0.000 claims description 4
- 229940032094 squalane Drugs 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 3
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 3
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 3
- 229960000458 allantoin Drugs 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 3
- 229910052740 iodine Inorganic materials 0.000 claims description 3
- 239000011630 iodine Substances 0.000 claims description 3
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 3
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 3
- 229940058015 1,3-butylene glycol Drugs 0.000 claims description 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 2
- 235000019647 acidic taste Nutrition 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims description 2
- 150000001450 anions Chemical class 0.000 claims description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 150000001768 cations Chemical class 0.000 claims description 2
- 229940106189 ceramide Drugs 0.000 claims description 2
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 230000001804 emulsifying effect Effects 0.000 claims description 2
- 239000010408 film Substances 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 125000002346 iodo group Chemical group I* 0.000 claims description 2
- 229940057995 liquid paraffin Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- KRPAJLYSLFNDOA-UHFFFAOYSA-N mephenesin carbamate Chemical compound CC1=CC=CC=C1OCC(O)COC(N)=O KRPAJLYSLFNDOA-UHFFFAOYSA-N 0.000 claims description 2
- 229950006838 mephenesin carbamate Drugs 0.000 claims description 2
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 229920002545 silicone oil Polymers 0.000 claims description 2
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 108010033040 Histones Proteins 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 239000002280 amphoteric surfactant Substances 0.000 claims 1
- 239000003945 anionic surfactant Substances 0.000 claims 1
- 125000006309 butyl amino group Chemical group 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 238000005984 hydrogenation reaction Methods 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000008400 supply water Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 210000001732 sebaceous gland Anatomy 0.000 abstract description 3
- 230000028327 secretion Effects 0.000 abstract description 2
- 239000004519 grease Substances 0.000 abstract 3
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical class 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 45
- 238000011282 treatment Methods 0.000 description 22
- 239000007788 liquid Substances 0.000 description 20
- 230000003255 anti-acne Effects 0.000 description 19
- 238000010790 dilution Methods 0.000 description 12
- 239000012895 dilution Substances 0.000 description 12
- 206010040882 skin lesion Diseases 0.000 description 12
- 231100000444 skin lesion Toxicity 0.000 description 12
- 150000001875 compounds Chemical class 0.000 description 10
- 241000191967 Staphylococcus aureus Species 0.000 description 9
- 239000000047 product Substances 0.000 description 8
- 241000186427 Cutibacterium acnes Species 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 240000007711 Peperomia pellucida Species 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000001815 facial effect Effects 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 206010015150 Erythema Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 231100000321 erythema Toxicity 0.000 description 3
- 235000019197 fats Nutrition 0.000 description 3
- 210000003780 hair follicle Anatomy 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 241000283977 Oryctolagus Species 0.000 description 2
- 229930040373 Paraformaldehyde Natural products 0.000 description 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000002146 bilateral effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 210000004907 gland Anatomy 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 229920002866 paraformaldehyde Polymers 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 229960001727 tretinoin Drugs 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 208000020154 Acnes Diseases 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 238000009631 Broth culture Methods 0.000 description 1
- 241000050051 Chelone glabra Species 0.000 description 1
- 206010011732 Cyst Diseases 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 244000148064 Enicostema verticillatum Species 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- AXISYYRBXTVTFY-UHFFFAOYSA-N Isopropyl tetradecanoate Chemical group CCCCCCCCCCCCCC(=O)OC(C)C AXISYYRBXTVTFY-UHFFFAOYSA-N 0.000 description 1
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical class O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 1
- 206010027626 Milia Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 241001303601 Rosacea Species 0.000 description 1
- 206010048810 Sebaceous hyperplasia Diseases 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 208000001435 Thromboembolism Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000002333 acnegenic effect Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229940031012 anti-acne preparations Drugs 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- -1 antibiotic Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- HQABUPZFAYXKJW-UHFFFAOYSA-N butan-1-amine Chemical compound CCCCN HQABUPZFAYXKJW-UHFFFAOYSA-N 0.000 description 1
- VXLZCUXYMYHOSV-UHFFFAOYSA-N butylazanium carbamate Chemical compound C(N)([O-])=O.C(CCC)[NH3+] VXLZCUXYMYHOSV-UHFFFAOYSA-N 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 230000023852 carbohydrate metabolic process Effects 0.000 description 1
- 235000021256 carbohydrate metabolism Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000008508 epithelial proliferation Effects 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 229940074928 isopropyl myristate Drugs 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 description 1
- 238000011587 new zealand white rabbit Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 150000004032 porphyrins Chemical class 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 201000004700 rosacea Diseases 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
Description
编号 | 稀释比例 | 实验结果 |
A | 1:4 | - |
B | 1:8 | - |
C | 1:16 | - |
D | 1:32 | + |
E | 1:64 | + |
F | 阴性 | + |
比较内容 | 治疗前 | 治疗后 |
皮损类型 | 3.97±1.21 | 2.57±1.79** |
皮损数量 | 4.31±1.23 | 2.95±1.58** |
皮损颜色 | 3.06±1.34 | 1.61±1.04** |
皮损肿痛 | 1.62±0.95 | 0.72±0.53** |
总分 | 12.96±3.58 | 7.85±1.45 |
比较内容 | 治疗前 | 治疗后 |
油脂含量 | 92.18±20.73 | 74.56±15.41** |
pH值 | 4.59±1.23 | 5.17±1.07* |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610937380.0A CN106511153B (zh) | 2016-10-25 | 2016-10-25 | 一种具有祛痘功效的纳米组合物及其化妆品或护肤品 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610937380.0A CN106511153B (zh) | 2016-10-25 | 2016-10-25 | 一种具有祛痘功效的纳米组合物及其化妆品或护肤品 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106511153A true CN106511153A (zh) | 2017-03-22 |
CN106511153B CN106511153B (zh) | 2020-02-04 |
Family
ID=58292975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610937380.0A Active CN106511153B (zh) | 2016-10-25 | 2016-10-25 | 一种具有祛痘功效的纳米组合物及其化妆品或护肤品 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106511153B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108186431A (zh) * | 2018-01-04 | 2018-06-22 | 苏州绿叶日用品有限公司 | 一种祛痘棒、祛痘组合物及其制备方法 |
CN112043616A (zh) * | 2020-10-21 | 2020-12-08 | 烟台新时代健康产业日化有限公司 | 一种基于缓释技术的祛痘复合物及祛痘精华液 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102764217A (zh) * | 2012-07-29 | 2012-11-07 | 何黎 | 一种含马齿苋提取物的功效性护肤品及制备方法 |
CN102949322A (zh) * | 2012-12-17 | 2013-03-06 | 扬州大学 | 一种功效化妆品及其制备方法 |
KR20130006724U (ko) * | 2012-05-14 | 2013-11-22 | 송혜민 | 여드름 치료를 위한 천연 식물과 한방재로 만든 얼굴팩과 먹는환을 구성한 조합물 |
JP2014037375A (ja) * | 2012-08-16 | 2014-02-27 | Dhc Co | 化粧料 |
CN104523473A (zh) * | 2014-12-03 | 2015-04-22 | 广州市尚医生物科技有限公司 | 一种抗痤疮微乳体系及其制备方法 |
US9351911B1 (en) * | 2015-07-30 | 2016-05-31 | Truth Aesthetics LLC | Topical skin care composition providing broad spectrum sunscreen |
CN105902422A (zh) * | 2016-04-13 | 2016-08-31 | 杭州程飞化妆品有限公司 | 一种祛痘精华液及其制备方法 |
CN105997658A (zh) * | 2016-06-18 | 2016-10-12 | 广州丹奇日用化工厂有限公司 | 含菊苣黄酮类物质的洁面膏及其制备方法 |
CN106822593A (zh) * | 2017-03-13 | 2017-06-13 | 南通蛇类治疗研究所 | 痤疮灵纳米乳液 |
-
2016
- 2016-10-25 CN CN201610937380.0A patent/CN106511153B/zh active Active
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20130006724U (ko) * | 2012-05-14 | 2013-11-22 | 송혜민 | 여드름 치료를 위한 천연 식물과 한방재로 만든 얼굴팩과 먹는환을 구성한 조합물 |
CN102764217A (zh) * | 2012-07-29 | 2012-11-07 | 何黎 | 一种含马齿苋提取物的功效性护肤品及制备方法 |
JP2014037375A (ja) * | 2012-08-16 | 2014-02-27 | Dhc Co | 化粧料 |
CN102949322A (zh) * | 2012-12-17 | 2013-03-06 | 扬州大学 | 一种功效化妆品及其制备方法 |
CN104523473A (zh) * | 2014-12-03 | 2015-04-22 | 广州市尚医生物科技有限公司 | 一种抗痤疮微乳体系及其制备方法 |
US9351911B1 (en) * | 2015-07-30 | 2016-05-31 | Truth Aesthetics LLC | Topical skin care composition providing broad spectrum sunscreen |
CN105902422A (zh) * | 2016-04-13 | 2016-08-31 | 杭州程飞化妆品有限公司 | 一种祛痘精华液及其制备方法 |
CN105997658A (zh) * | 2016-06-18 | 2016-10-12 | 广州丹奇日用化工厂有限公司 | 含菊苣黄酮类物质的洁面膏及其制备方法 |
CN106822593A (zh) * | 2017-03-13 | 2017-06-13 | 南通蛇类治疗研究所 | 痤疮灵纳米乳液 |
Non-Patent Citations (2)
Title |
---|
葛静: "《五谷杂粮养生一本全》", 30 September 2013, 天津科学技术出版社 * |
马振友: "《最新皮肤科药物手册(第2版)》", 30 June 2008, 世界图书出版西安公司 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108186431A (zh) * | 2018-01-04 | 2018-06-22 | 苏州绿叶日用品有限公司 | 一种祛痘棒、祛痘组合物及其制备方法 |
CN112043616A (zh) * | 2020-10-21 | 2020-12-08 | 烟台新时代健康产业日化有限公司 | 一种基于缓释技术的祛痘复合物及祛痘精华液 |
Also Published As
Publication number | Publication date |
---|---|
CN106511153B (zh) | 2020-02-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Holzchuh et al. | Clinical treatment of ocular Demodex folliculorum by systemic ivermectin | |
EP3708152B1 (en) | Azelaic acid gel, and preparation method and application thereof | |
CN106620653B (zh) | 一种用于治疗皮肤创面的组合物及其制备方法 | |
CN1547475B (zh) | 含电子转移试剂的磷酸酯衍生物的皮肤制剂 | |
CN104523473B (zh) | 一种抗痤疮微乳体系及其制备方法 | |
CN102283792B (zh) | 一种天然祛痘乳霜 | |
CN110585114B (zh) | 一种调节皮肤微生物菌群的杀菌组合物及其应用 | |
CN106309237A (zh) | 一种透明质酸私部护理凝胶及制备方法 | |
CN107375032B (zh) | 一种修复皮肤屏障的组合物及制备方法 | |
CN109260059B (zh) | 一种具有祛痘和皮肤修复功效的精油组合物及应用 | |
CN106420381A (zh) | 青蒿素类成分或其组合物在皮肤护理中的新应用 | |
CN109865160A (zh) | 一种类脂液晶复合物及其制备方法 | |
CN105796459A (zh) | 一种含水解珍珠粉柔性纳米脂质体的保湿凝胶 | |
CN110302223A (zh) | 一种用于修复毛囊的育发液制剂及其制备方法 | |
CN106511153A (zh) | 一种具有祛痘功效的纳米组合物及其化妆品或护肤品 | |
CN103230359B (zh) | 具有祛痘功效的护肤组合物、面膜及其制备方法 | |
CN105963243B (zh) | 一种治疗寻常痤疮的龙脑香樟精油缓释乳膏及其制备方法 | |
CN108096315A (zh) | 一种新一代抗痤疮复方药物的制备方法及制剂 | |
CN117045523A (zh) | 一种高含量壬二酸组合物及其制备方法 | |
Kim et al. | Safety evaluation and consideration of 4 Pin Multi-needle for meso-therapy | |
DE60212842T2 (de) | Dermatologische zusammensetzungen, die nikotinsäure oder nikotinsäureamid und sphingoid-base enthalten | |
AU2020333005B2 (en) | Compositions and methods for the treatment of anterior blepharitis and posterior blepharitis | |
CN107174535A (zh) | 一种具有抗炎透皮修复功效的透明质酸组合物及应用 | |
CN105769621B (zh) | 一种组合物在制备温和祛痘化妆品中的用途 | |
CN103463308B (zh) | 茶多酚硬脂酸酯的应用以及一种治疗银屑病的药物组合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20200609 Address after: Room 601, 6th floor, Shandong News Building, 143 Lishan Road, Lixia District, Jinan City, Shandong Province, 250000 Patentee after: Shandong qianse Biotechnology Co.,Ltd. Address before: 606, room 250013, B building, Shandong News Building, 143 Lishan Road, Lixia District, Shandong, Ji'nan Patentee before: JINAN ZK COMMERCE AND TRADE Co.,Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20240305 Address after: Room 0113, Building 4, Minzhu Community, Linkou County, Mudanjiang City, Heilongjiang Province, 157000 Patentee after: Heilongjiang Zhanxi Biotechnology Co.,Ltd. Country or region after: China Address before: Room 601, 6th floor, Shandong News Building, No. 143, Lishan Road, Lixia District, Jinan City, Shandong Province, 250000 Patentee before: Shandong qianse Biotechnology Co.,Ltd. Country or region before: China |
|
TR01 | Transfer of patent right |