CN106822593A - 痤疮灵纳米乳液 - Google Patents

痤疮灵纳米乳液 Download PDF

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Publication number
CN106822593A
CN106822593A CN201710164484.7A CN201710164484A CN106822593A CN 106822593 A CN106822593 A CN 106822593A CN 201710164484 A CN201710164484 A CN 201710164484A CN 106822593 A CN106822593 A CN 106822593A
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China
Prior art keywords
acne
nanoemulsions
spirit
constituted
natural plants
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CN201710164484.7A
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English (en)
Inventor
成钢
成进学
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Nantong Snakes Treating Institute
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Nantong Snakes Treating Institute
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Priority to CN201710164484.7A priority Critical patent/CN106822593A/zh
Publication of CN106822593A publication Critical patent/CN106822593A/zh
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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Abstract

本发明公开了一种痤疮灵纳米乳液，是属于现代中药化妆品纳米乳液配置生产技术领域。由所述天然植物药金银花山豆根，芙蓉花穿心莲，白花蛇舌草败酱草，冬虫夏草灵芝，白癣皮地肤子，痤疮纳米乳液组成。本方具有清热解毒，活血祛瘀除湿，清热解毒利湿，养血润肤，活血软坚，疏通体表经络，抗痤疮丙酸杆菌活性，广谱抑菌、抗菌，消炎，抗雄性激素以抑制皮脂腺的分泌，对金黄色葡萄球菌、表皮金黄色葡萄球菌，D群链球菌，丙酸杆菌，具有明显的体外抑菌作用，并还能促进表皮细胞生长的作用，具有收散，解热化瘀，由于使用天然植物纳米粉碎技术，渗透吸收率强，对痤疮疗效显著，治愈率高，复发率低，无毒副作用。

Description

痤疮灵纳米乳液
技术领域：
本发明公开了一种痤疮灵纳米乳液，是属于现代中药化妆品纳米乳配制生产技术领域。
背景技术：
痤疮，俗称青春痘、粉刺、暗疮，中医古代称面疮，酒刺，是一种发生于毛囊皮脂腺的慢性皮肤病，多发于头面部、颈部、前胸后背等皮脂腺丰富的部位。痤疮(青春痘)的主要临床表现为黑头粉刺、白头粉刺、炎性丘疹、脓包、结节、囊肿，易形成色素沉着、毛孔粗大甚至瘢痕样损害。多见于青年男女。
现代医学认为，痤疮是毛囊皮脂腺的慢性炎症，是一种多因素疾病。至今，其发病机制尚未完全明了。皮脂的淤积，毛囊内细菌、螨虫等微生物感染，内分泌因素，是痤疮发病的主要因素。雄性激素在痤疮的发病过程中起着重要的支配作用。此外，痤疮的发病，与过食甜食、便秘、精神紧张、遗传因素、锌缺乏、气候闷热潮湿、使用化妆品以及使用某些药物如碘化物、溴化物、卤化物、肾上腺皮质激素、苯妥英钠、吸烟等有关。痤疮多发于面颊、前额，亦可见胸背。初起皮症为芝麻到绿豆大小，与肤色相同或红色，顶端日渐呈现黑头，可挤压出黄色粉渣，易遗留凹陷瘢痕。皮疹散在分布，部分患者皮疹扩大成黄豆大或蚕豆大小，呈暗红色，消退后形成瘢痕疙瘩。
西医治疗本病主要是去除病因，寻常痤疮只要不乱挤，不乱用药，积极治疗，一般愈后较好。结节型、囊肿型、聚合型愈后欠佳，治疗比较棘手，因而对此类患者应尽早采取积极正确的治疗方法，以免瘢痕形成，影响容貌美观。
中医学称之为“肺风粉刺”、“面粉渣”、“酒刺”、“嗣面”、“风刺”等。认为素体血热偏盛是痤疮发病的根本；饮食不节，外邪侵袭是治病的条件；血瘀痰结使病情复杂深重。若肺经风热者，治以清肺散热；湿热蕴结者，治以清热化湿通腑；痰湿凝结者，治以消痰软坚，活血化瘀。通过辩证施治，以清除血热偏盛、肺胃积热、外感风热、气血凝塞、血瘀痰结等病理因素，达到预期的疗效。
发明内容：
本发明的目的在于提供一种痤疮灵纳米乳液。
本发明的技术解决方案是：
1、一种痤疮灵纳米乳液，其特征是：所述天然动植物药金银花蝮蛇皮治痤疮纳米乳液，按下列质量份配比组成％
制备方法：将天然动植物物料粉碎成60目得粗粉，加入8倍的水，制成混悬液在胶体磨中混匀进行细化处理，细化液再置于均质机中进行纳米花粉碎，制成粒径在0.9-2μm的天然营养材料纳米化液。趁热用纱布或棉球蘸药液擦洗患处，每次擦洗15～20分钟，每日2次，可连续用药7～14天，获效后可继续用药直至痊愈。乳化液中药可使用2～3天，每次擦洗前后应把药液加热或煮开。注：也可取药面少许(面积大小)，用温水调糊状，现用现调，每晚睡前用手蘸药，搓擦患处，第2天清晨洗脸，7天痊愈。本方也可改为汤剂(去硫磺粉、冰片)煎服同样有效。
功效：亲热解毒，活血通络，祛湿消毒，杀虫。
适应病症：痤疮，青年扁平疣，皮肤疖肿。青春痘。
方解：痤疮扁平疣及皮肤疖肿皆有风热湿毒刻于皮肤，阻塞经络，气血壅滞坐直。治以清热解毒，活血祛瘀除湿。本方以马齿笕、金银花、山豆根清火解毒；加菌陈、栀子、黄柏、苍术清热利湿；配川穹，丹参养血润肤，活血软坚，疏通体表经络，同时可防止清热泻火之合而用药爆寒过度耗损阴津而伤及肌肤；佐以苦参性辛温，达标走肌肤，引诸药直达病灶，之，组成清热解毒，活血化瘀，祛湿消疹之剂，故作为疮疔疖肿及疣疹的外用洗剂，能达到显效迅速，药理研究表明，本方中的马齿笕，金银花、山豆根、菌陈、栀子、黄柏、苍术、丹参、川穹等单味煎剂均具有高、中效的抗痤疮丙酸杆菌活性及光谱的抑菌作用。其中丹参、川穹的有效成分还具有调节机体免疫机能的功效。此外丹参酮还被证实具有抗雄性激素和类似糖皮质激素的抗炎作用。上述主要功效与西医对痤疮采用抗菌消炎、抗雄性激素以抑制皮脂腺分泌的治则颇为吻合。
临床应用：痤疮和扁平疣多见于青年，好发于面部。痤疮的主要表现为粉刺、丘疹、结节、脓疮及囊肿型皮损。本洗剂为各型痤疮，扁平疣及皮肤疖肿的通用方，对局部红肿较重，炎症明显者，应加用地丁、蒲公英各20g；对结节、囊肿难以消退者加用渐贝母、海藻、桃仁、红花各15g；扁平疣患者最好能配合每日早晨空腹食用米醋中，7天后捞出煮食。
注意事项：忌食辛辣油腻及甘甜过度食物。若应用本方治疗14天后效果不明显，宜改用其他疗法。对伴发严重细菌感染着应同时加用抗生素治疗。
疗效：2015年5～6月份用本乳液治疗的痤疮患者35例，结果治愈21例，显效8例，好转4例，无效2例，总有效率为94.29％。同期应用本法治疗扁平疣9例均获痊愈。
典型病例：马某，女，22岁，青年教师2015年6月8日就诊患扁平疣及痤疮7年，跑遍通城各医院的皮肤科求医无效，因面部长满扁平疣疹及痤疮结节而影响美观，内心非常痛苦，曾动过轻生之念头。后应用本方剂外洗7天后，疣疹结节开始脱落，皮损变小20天后痊愈。
2、一种痤疮灵纳米乳液，其特征是：所述天然植物芙蓉花穿心莲外治痤疮纳米乳液，按下列质量份配比组成％
制备方法：将除水与酒精外涂天然植物要粉碎成60目得粗粉加入8倍的水，制成混悬液，在肢体磨中混合进行细化处理，细化液再置于均质机中进行混合细化，细化液再进行纳米花粉碎，制成粒径为0.1～2μm的天然植物乳液与酒精混合静置一周后备用装瓶打包入库。
本品对金黄色葡萄球菌表皮金黄色葡萄球菌D群链球菌，丙酸杆菌有明显的体外抑菌作用，并还有促进表皮细胞生长的作用，具有收散，解热化瘀，对治疗青年男女痤疮疗效显著治愈率高，复发率低，对人体无毒副作用。
3、一种痤疮灵纳米乳液，其特征是：所述天然植物白花蛇舌草败酱草治痤疮纳米乳液，按下列质量份配比组成％
制备方法
(1)将水杨酸、苯甲酸溶解在浓度为10％～35％的羊蹄酊中，静置密封1～40h后，加入斑蝥，再加入浓度为50％～75％的酒精，浸泡1～20d后，过滤去渣，将滤液加热沸腾，搅拌至45℃时加入(2)乳液胶体磨中混合进行细化处理，细化液再置于均质机中进行均匀细化及纳米化粉碎制成粒径在0.1-2μm的天然植物纳米乳液本品为外用捈剂，用于治疗各种类型的痤疮及皮疹，也可用于治疗面部的粉刺、汗斑、嘴角生疮，对鼻炎也有良好疗效。
(2)本发明渗透吸收快，工艺简单，使用方便，见效快，效果好，对皮肤无腐蚀性，用后无不良反应。
4、一种痤疮灵纳米乳液，其特征是：所述天然植物有除菊花斑蝥增白美容治痤疮纳米乳液，按下列质量份配比组成％
制备方法：将天然植物药粉碎成60目得粗粉，加8倍的水制成混悬液在肢体磨中进行混合细化处理，细化液再置于均质机中进行均质细化成粒径在0.1-2μm的天然植物纳米乳液，沉淀静置72h后再酒精充分搅拌混合再静置72h后装瓶入库。
本品是一种多功能痤疮液。具有清热解毒、活血化瘀。疏通毛孔、清洁毛囊的作用，主要用于治疗面部粉刺，同时可嫩肤增白。
使用方法如下：用温水将面部清洗1遍，再用药棉吸收取部分药水，轻轻擦拭于面部，手指适度用力按摩面部5～10min，之后可洗面部，也可以不洗，因为本药液可被皮肤大部分吸收，少量会发到空气中，且不会在皮肤上留下痕迹。
用后药棉不能重复使用，每次用8个小棉球分别擦拭1遍，每天擦4次以上最佳。
使用注意事项：使用本品期间，须避免强烈日光暴晒和避免食用辛辣油腻食品；如皮肤过敏或有外伤，用后呈水肿、脓包等，应停止使用。
本品加工制作简单，成本低、价格便宜，价格便宜，它不仅对痤疮有奇特的疗效，疗程短、不复发，属自然合成，不会破坏天然植物药物的有效成分；配方合理，使用效果显著；而且可使皮肤增白，软化皮肤同时使皮肤增加弹性、抗过敏和有光泽，中西药合成协同使用不易产生抗药性。
本品是一种多功能性治疗痤疮纳米乳液用于治疗面部的粉刺疙瘩，愈后不留疤痕。使用时先将面部洗净，然后将药液涂抹在面部即可。无毒副作用，对人体和皮肤无任何不良影响，安全可靠。
5、一种痤疮灵纳米乳液，其特征是：所述天然植物冬虫夏草灵芝快速美容治痤疮纳米乳液，按下列质量份配比组成％
制备方法：将天然植物药粉碎成60目得粗粉加入8倍量的水制成混悬液在胶体研磨机中进行混合细化处理，细化液再置于均质机中进行细化成粒径在0.1-2μm的天然植物纳米乳液。
本品是一种快速治疗痤疮的天然植物乳液，可以直接涂在病变外，本品可防脱敏，对中性油性皮肤菌可使用，即是皮肤过敏性也可使用，本品可提高人体免疫力，增强抗病能力，可祛斑，除皱，润肤，美容。
本方可达速效、高效。安全、简便、价廉、等医疗，预防、健康美溶于一体，达到标本兼治的作用。
6、一种痤疮灵纳米乳液，其特征是：所述天然动植物地肤子治痤疮纳米乳液，按下列质量份配比组成％
制备方法：将以上中药原料粉碎后用常规二氧化碳萃取或用60％乙醇提取的方法提取，滤液经薄膜蒸发、回收乙醇，并浓缩成1∶1(即每毫升含原生药1g)，相对密度为1.03-1.05的流浸膏将流浸膏真空干燥研细与其他物料共同混合，将其混合物料再用纳米粒径超细微化通用装置将物料的大分子进行破碎、乳化、均质、分散，从而粒化成纳米粒径的小分子过1800-2200目筛，中心粒径为0.1-2μm的天然植物纳米乳，因为药物的吸收常受药物在吸收部位溶出速度的支配，而减小粒径，可以增大在暴露在介质中的表面积，而促进溶解，进而提高药物的吸收度和利用率，增大了药效和治疗效果。
(2)将天然植物中药纳米乳液与蛇胆汁、渗透促进剂、氮酮、吐温80和香精混合均匀即可得用于治疗痤疮的蛇胆痤疮纳米乳液。
本品工艺简单，使用方便；产品为纯中药制剂，中草药的醇提液为活性成分，具有对各类型痤疮显效快、安全可靠的优点。
现代中药化妆品制作工艺及配方的研究就是在继承和发扬我国中医药优势和特色的基础上，借鉴国际认可的医药标准和规范制订出本发明的标准和规范，充分利用现代科学技术的理论、管理理念、先进的科技方法和手段，研究、开发和生产出以“现代化”和“高技术”为特征的“安全、高效、稳定、可控”的现代中药化妆品，使中药化妆产业实现“大品种”、“大企业”和“大市场”，成为具有强大国际市场上的份额。运用纳米技术将单位中药、复方中药的有效成分、部位或整个中药饮片进行纳米化处理，或在原有复方中加入纳米化的中药，通过改变给药途径、药物作用方式、药物作用部位等，发挥出常态中药无法比拟的功效，并且避免了传统中药及其复方在加工过程中繁琐的处理工序。
我国在中药工业领域中研究及应用纳米技术，现今仍处于初始阶段，然而取得的成果却令人振奋，如用纳米级粒径超微化装置处理的中药紫河车、冬虫夏草、地龙干等可以全部被皮肤吸收；纳米级矿物类中药药材内服吸收效率大幅度提高，如钙、铁、锌等制剂可以达到98％以上。有研究表明，不同粒径的矿物中药雌黄对肿瘤细胞S180和上皮细胞EC-304等的细胞毒性和诱导细胞凋亡作用有明显的尺寸效应，纳米雌黄颗粒表现出尤为突出的生物效应。华中科技大学的徐碧辉教授等将中药牛黄(雌黄)加工到纳米量级，其理化性质(理化性质代表药材的内在质量，通过它可以对药材定性和定量的鉴别)发生了惊人的变化并申请到我国纳米中药的第一个专利。所以纳米中药化妆品的开发和应用具有广阔的空间。
下面结合实施例对本发明进一步阐明：
具体实施方法：
实施例1：一种痤疮灵纳米乳液，其特征是：所述天然动植物药金银花蝮蛇皮治痤疮纳米乳液，按下列质量份配比组成％
实施例2：一种痤疮灵纳米乳液，其特征是：所述天然植物芙蓉花穿心莲外治痤疮纳米乳液，按下列质量份配比组成％
实施例3：一种痤疮灵纳米乳液，其特征是：所述天然植物白花蛇舌草败酱草治痤疮纳米乳液，按下列质量份配比组成％
实施例4：一种痤疮灵纳米乳液，其特征是：所述天然植物有除菊花斑蝥增白美容治痤疮纳米乳液，按下列质量份配比组成％
实施例5：一种痤疮灵纳米乳液，其特征是：所述天然植物冬虫夏草灵芝快速美容治痤疮纳米乳液，按下列质量份配比组成％
实施例6：一种痤疮灵纳米乳液，其特征是：所述天然动植物地肤子治痤疮纳米乳液，按下列质量份配比组成％

Claims (6)

1.一种痤疮灵纳米乳液，其特征是：所述天然动植物药金银花蝮蛇皮治痤疮纳米乳液，按下列质量份配比组成％
2.一种痤疮灵纳米乳液，其特征是：所述天然植物芙蓉花穿心莲外治痤疮纳米乳液，按下列质量份配比组成％
3.一种痤疮灵纳米乳液，其特征是：所述天然植物白花蛇舌草败酱草治痤疮纳米乳液，按下列质量份配比组成％
4.一种痤疮灵纳米乳液，其特征是：所述天然植物有除菊花斑蝥增白美容治痤疮纳米乳液，按下列质量份配比组成％
5.一种痤疮灵纳米乳液，其特征是：所述天然植物冬虫夏草灵芝快速美容治痤疮纳米乳液，按下列质量份配比组成％
6.一种痤疮灵纳米乳液，其特征是：所述天然动植物地肤子治痤疮纳米乳液，按下列质量份配比组成％
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Publication number Priority date Publication date Assignee Title
CN106511153A (zh) * 2016-10-25 2017-03-22 济南佐康商贸有限公司 一种具有祛痘功效的纳米组合物及其化妆品或护肤品
CN114404489A (zh) * 2018-08-06 2022-04-29 上海萱蕙生物科技有限公司 一种喷雾液及其制备方法和应用

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CN102018937A (zh) * 2010-12-14 2011-04-20 金亮亮 一种治疗痤疮的药物及制备方法

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Publication number Priority date Publication date Assignee Title
CN102018937A (zh) * 2010-12-14 2011-04-20 金亮亮 一种治疗痤疮的药物及制备方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106511153A (zh) * 2016-10-25 2017-03-22 济南佐康商贸有限公司 一种具有祛痘功效的纳米组合物及其化妆品或护肤品
CN114404489A (zh) * 2018-08-06 2022-04-29 上海萱蕙生物科技有限公司 一种喷雾液及其制备方法和应用

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