CN106491922A - A kind of Chinese medicine formula medicine and its capsule suitable for sluggishness of qi and phlegm hyperlipemia - Google Patents
A kind of Chinese medicine formula medicine and its capsule suitable for sluggishness of qi and phlegm hyperlipemia Download PDFInfo
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Abstract
The invention provides a kind of Chinese medicine formula medicine suitable for sluggishness of qi and phlegm hyperlipemia, the active component of described Chinese medicine formula medicine is 6 by weight ratio:6:6:6:3:3 Bulbus Allii powder, Radix Salviae Miltiorrhizae, Fructus Crataegi, Pericarpium Citri Reticulatae, Flos Sophorae and Radix Notoginseng composition；The Chinese medicine formula medicine suitable for sluggishness of qi and phlegm hyperlipemia that the present invention is provided has good therapeutical effect to hyperlipemia.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for treating hyperlipidemia, is applied to the stagnation of QI according to more particularly to a kind of
The Chinese medicine formula medicine of phlegm stagnation syndrome type hyperlipemia and its capsule.
Technical background
Hyperlipemia is referred to and make one or more lipid in blood plasma sick higher than normal due to lipid metabolism or operating exception
Disease.Hyperlipemia is the primary risk factor of atherosclerosiss (AS), changes with dietary structure with the quickening pace of modern life
Become, the mortality rate caused by cardio-cerebral diseases occurs on the basis of AS and rises.Hyperlipemia is commonly encountered diseases, frequently-occurring disease, it with
Cardiovascular and cerebrovascular disease has very close relationship.Improve that dyslipidemia can be prevented or reversal of atherosclerosis pathological changes are entered
Exhibition.Therefore, Comprehensive Therapy for Correcting Lipidemia has very important effect to the primary and secondary prevention of incidence of coronary heart disease.
Hyperlipemia is modern medicine name of disease, and Chinese medicine does not have corresponding name of disease, is only described in the literature,
Sporadically appear among the record of the disease such as " fertile people ", " expectorant is turbid ", " thoracic obstruction ", e.g.,《Ling Shu Miraculous Pivot or Divine Axis disorder of defensive QI》Say:" people have fat, have cream,
There is meat ".《Five addiction body fluid of Ling Shu Miraculous Pivot or Divine Axis is other》Medium cloud:" body fluid of grain rice and combined into cream fat, endosmosis empty in bone, tonification brains, and under
Flow in cloudy stock ".The clever periodical Ling Shu Miraculous Pivot or Divine Axis of Zhang Zhi is focused》Medium cloud:" gas of middle Jiao, steams body fluid, and which is precise and tiny to overflow in outer then skin and flesh cream fertilizer, remaining
Plentiful in interior then cream fat ".It is possible thereby to think, Chinese medicine its ' cream fat " refer to ' blood fat sayed ".Meanwhile, also explanation cream fat is
One of Human Physiology composition, is belonged to body fluid category, and can mutually be converted with other compositions of body fluid.Tianjin is cream from turbidity, coagulates
It is then fat.Which comes from essence of water and grain, by transporting and transforming function of the spleen and stomach compress, follows arteries and veins with blood up and down, and operation whole body nourishes the five internal organs six to make moist
Internal organs, extremity bones of the body collectively, have note bone sky, supplementing the brain marrow, the effect of profit skin.Once cream fat in vivo transfer, drain etc. occur abnormal,
The turbid phlegm-damp of pathologic fat is then turned to, blood vessels are injected, causes hyperlipemia.
The hyperlipidemia of hyperlipemia is pathologic cream fat, is that the expectorant in blood is turbid.Expectorant with drink, different name is similar.Thick turbid person is
Expectorant, thin person are drink, such as Zhang Jingyue Russia Jing Yue's complete work phlegm retention》Medium cloud:" change of lid sputum, this are good for fruit spleen stomach strengthening by water paddy
As young and vigorous person flows, then with food with change, all into QI and blood, here get Liu and be expectorant, only which has and can change to the greatest extent and ten stay one or two, then one or two is expectorant
, ten to stay three four fundamental rules three or four be expectorant ".
Content of the invention
For solving the above problems, the invention provides a kind of Chinese medicine formula medicine suitable for sluggishness of qi and phlegm hyperlipemia
Thing, the active component of described Chinese medicine formula medicine is 6 by weight ratio:6:6:6:3:3 Bulbus Allii powder, Radix Salviae Miltiorrhizae, Fructus Crataegi, Pericarpium Citri Reticulatae,
Flos Sophorae and Radix Notoginseng composition.
A kind of preparation method of the Chinese medicine formula medicine is comprised the following steps：
1. weight ratio according to claim 1 weighs medical material；
2. Radix Notoginseng and Pericarpium Citri Reticulatae are ground into fine powder；
3. Radix Salviae Miltiorrhizae, Fructus Crataegi and Flos Sophorae are added 60% alcohol reflux three times, every time plus 6 times of amounts of ethanol, reflux, extract, 2 is little
When, filtration, merging filtrate obtain ethanol extract；
4., by ethanol extract under the conditions of 60 DEG C, reclaim ethanol and be concentrated into the clear paste that relative density is 1.10～1.14；
5. Radix Notoginseng powder is added in clear paste, mix, fully dry, pulverize under the conditions of 80 DEG C, add garlic powder Pericarpium Citri Reticulatae
Powder, obtains the Chinese medicine formula medicine suitable for sluggishness of qi and phlegm hyperlipemia.
Another preparation method of the Chinese medicine formula medicine is comprised the following steps：
1. weight ratio according to claim 1 weighs medical material；
2. Radix Notoginseng was ground into the granule of 20 mesh sieve, the ethanol with 40% starts to ooze more than 12h as solvent immersion
Filter, percolation solvent consumption is 10 times of medical material weight, obtains Radix Notoginseng alcohol extract；
3., by Radix Notoginseng alcohol extract under the conditions of 50 DEG C, reclaim ethanol and be concentrated into the Radix Notoginseng that relative density is 1.10～1.14
Clear paste；
4. Pericarpium Citri Reticulatae, Radix Salviae Miltiorrhizae, Fructus Crataegi and Flos Sophorae are mixed, the ethanol with 70% starts percolation as solvent immersion more than 12h,
Percolation solvent consumption is 10 times of medical material weight, obtains mixing alcohol extract；
5. alcohol extract extract will be mixed under the conditions of 50 DEG C, it is 1.10～1.14 to reclaim ethanol and be concentrated into relative density
Mixing clear paste；
6. merge Radix Notoginseng clear paste and mixing clear paste, fully dry, pulverize under the conditions of 60 DEG C, add Bulbus Allii powder and Pericarpium Citri Reticulatae
Powder, obtains the Chinese medicine formula medicine suitable for sluggishness of qi and phlegm hyperlipemia.
Will be directly encapsulated for the Chinese medicine formula medicine suitable for sluggishness of qi and phlegm hyperlipemia described above, former per 750g
Medical material prepares 1000 capsules.
The method have the benefit that：The Chinese medicine formula suitable for sluggishness of qi and phlegm hyperlipemia that the present invention is provided
Medicine has good therapeutical effect to hyperlipemia.
Specific embodiment
Preparation of the embodiment 1 for test specimen
1st, the preparation of Bulbus Allii powder：1. from when harvesting, leaf Huang straw are withered, head is big, the broken wound of pure white lobe meat, no disease and pests harm, mechanical
Bulbus Allii as raw material, rejecting a little, lobe meat has pest and disease damage or has the Bulbus Allii of mechanical damage.2. the Bulbus Allii that chooses is washed with clear water
Strip off point lobe after net, is then placed in cold water and soaks 1 hour or so, rubs with the hands and removes fur clothing, picks up garlic clove, drain Yu Shui.3. will drain
The garlic clove of water is put in beater or pulverizer carries out crushing beating.During beating, the water purification of Jia 1/3 in garlic clove；After beating, with thick
Filtered through gauze serosity, removes the debris such as remaining fur clothing.4. turned left the right side with rotating speed per minute 12000, centrifugation removes moisture.But
Total requirement is once rapidly moisture will to be eliminated, it is impossible to stall for time, in case spoiled impact quality starched by Bulbus Allii.Meanwhile, instrument makes
Must rinse well immediately with after, in order to avoid there is abnormal flavour when using next time.5. dehydrated wet Bulbus Allii powder is shakeout immediately and is placed on
On drip pan, then drip pan is put into drying room baking.Drying room need to keep constant temperature at 50 DEG C or so, about dry 5 hours, to being completely dried；
Obtain Bulbus Allii powder.
2nd, Bulbus Allii powder 150g, Radix Salviae Miltiorrhizae 150g, Fructus Crataegi 150g, Pericarpium Citri Reticulatae 150g, Flos Sophorae 75g, Radix Notoginseng 75g weighed, above Six-element,
In addition to Bulbus Allii powder, Radix Notoginseng and Pericarpium Citri Reticulatae are ground into fine powder.Take Radix Salviae Miltiorrhizae, three taste of Fructus Crataegi and Flos Sophorae, plus 60% alcohol reflux three times,
Every time plus 60% ethanol, 6 times of amounts, reflux, extract, 2 hours, filtration, merging filtrate, reclaim ethanol and be concentrated into relative density and be
The clear paste of 1.10～1.14 (60 DEG C).Radix Notoginseng powder is mixed with clear paste, is dried (80 DEG C), crushed, add Bulbus Allii powder and tangerine peel powder,
Mix, obtain final product the Chinese medicine formula medicine for sluggishness of qi and phlegm hyperlipemia, as experimental group A.
3rd, Bulbus Allii powder 150g, Radix Salviae Miltiorrhizae 150g, Fructus Crataegi 150g, Pericarpium Citri Reticulatae 150g, Flos Sophorae 75g, Radix Notoginseng 75g are weighed, by Radix Notoginseng powder
The granule of 20 mesh sieve was broken into, the ethanol with 40% soaks as solvent and starts percolation more than 12h, and percolation solvent consumption is medicine
10 times of material weight, obtains Radix Notoginseng alcohol extract；By Radix Notoginseng alcohol extract under the conditions of 50 DEG C, reclaim ethanol and be concentrated into relative density and be
1.10～1.14 Radix Notoginseng clear paste；Pericarpium Citri Reticulatae, Radix Salviae Miltiorrhizae, Fructus Crataegi and Flos Sophorae are mixed, the ethanol with 70% exceedes as solvent immersion
12h starts percolation, and percolation solvent consumption is 10 times of medical material weight, obtains mixing alcohol extract；Alcohol extract extract will be mixed at 50 DEG C
Under the conditions of, reclaim ethanol and be concentrated into the mixing clear paste that relative density is 1.10～1.14；Merge Radix Notoginseng clear paste and mixing clear paste,
Fully dry, pulverize under the conditions of 60 DEG C, add garlic powder tangerine peel powder, obtain suitable for sluggishness of qi and phlegm hyperlipemia
Medicine composition medicine, used as experimental group B.
4th, Bulbus Allii powder 150g, Radix Salviae Miltiorrhizae 150g, Fructus Crataegi 150g, Pericarpium Citri Reticulatae 150g, Flos Sophorae 75g, Radix Notoginseng 75g are weighed, by Radix Notoginseng powder
The granule for being broken into 20 mesh sieve is standby；Radix Notoginseng powder, Pericarpium Citri Reticulatae, Radix Salviae Miltiorrhizae, Fructus Crataegi and Flos Sophorae are mixed, the reflux, extract, that adds water three times,
Add water every time 6 times and measure, reflux, extract, 2 hours, filtration, merging filtrate reclaim and be concentrated into relative density for 1.10～1.14 (60
DEG C) clear paste.Radix Notoginseng powder is mixed with clear paste, is dried (80 DEG C), crushed, add Bulbus Allii powder, mixed, obtain final product turbid for stagnation of QI expectorant
The Chinese medicine formula medicine of type hyperlipemia, used as experimental group C.
Embodiment 2 is applied to the activity investigation of the Chinese medicine formula medicine of sluggishness of qi and phlegm hyperlipemia
Rat is randomly divided into 6 groups by weight, shitosan group, Wei Zhikang groups (dimension fat recovering capsule, manufacturer：Wish in Chongqing
Er An pharmaceutcal corporation, Ltds, Chinese medicines quasi-word B20160002), experimental group A, experimental group B, experimental group C, high lipid food matched group and
Normal feedstuff matched group is each 8.Normal feedstuff control rats feed normal feedstuff, the equal feed high lipid food meals of other group of rat
Food.Shitosan group, Wei Zhikang groups, experimental group A, experimental group B and experimental group C rats give shitosan 100mg/ respectively through gavage
Kg, Wei Zhikang group 15g crude drug/kg, experimental group A, experimental group B that embodiment 1 is prepared and experimental group C extract 15g crude drugs/
kg.High lipid food matched group and normal feedstuff matched group gavage give distilled water, and gavage volume is 20ml/kg, 1 time/d.Each group
The equal feed of rat 4 weeks, 1 times a week weight.At the 4th weekend, the feces of continuous 3d are collected respectively, fecal fat content is adopted
Ether extraction detection by quantitative.Rat is taken a blood sample through retroorbital venous clump, determines three phthalein glycerol of serum, T-CHOL, glucose,
Enzymatic method detection by quantitative is adopted on automatic chemical analyzer.Serum free fatty acid and malonaldehyde are respectively adopted cupferron method
Operate by kit specification with thiobarbituric acid reaction method.And weigh.MAIN OUTCOME MEASURES:1. each group rat weight and
Weightening.2. each group Rats Organs and Tissues and surrounding genital adipose tissue mass and relative mass.3. each group rat blood biochemical indicator.
4. each group rat fecal fat quality.The body weight change for wherein feeding surrounding mice is as shown in table 1.
Table 1 feeding four weeks after each group rat body weight quality and its Gain weight (n=8, g)
Note：Compare with high lipid food matched group, * P<0.05, compare with basic test portion group,△P<0.05.
As shown in table 1, after 4 weeks, high lipid food control rats weight and its weightening are apparently higher than normal feedstuff for feed
Matched group (P<0.05), it is adaptable to the Chinese medicine formula medicine each group of sluggishness of qi and phlegm hyperlipemia, Wei Zhikang groups and shitosan group
Rat weight and its weightening are significantly lower than high lipid food matched group (P<0.05), wherein experimental group B is in rat control body weight
There is more obvious action, show to mitigate weight suitable for the Chinese medicine formula medicine of sluggishness of qi and phlegm hyperlipemia and subtract
Slow weight increases.The Chinese medicine formula drug extract rat weightening for being applied to sluggishness of qi and phlegm hyperlipemia is less than each tested material
Alone group, but no significant difference (P>0.05).
The hematochemistry change of feed each group rat after 4 weeks is shown in Table 2.
After the feeding four weeks of table 2, the biochemical blood parameters of each group rat compare
| Group | Triacylglycerol (nmol/L) | T-CHOL (nmol/L) | Free fatty (nmol/L) | Blood glucose (nmol/L) |
| High lipid food matched group | 2.41±1.16* | 2.76±0.46 | 759.91±115.09 | 6.95±0.48 |
| Normal feedstuff matched group | 1.32±0.40 | 1.58±0.21* | 704.81±167.75 | 4.23±0.52* |
| Shitosan group | 1.16±0.44* | 2.25±0.57 | 739.81±191.20 | 3.79±0.85* |
| Wei Zhikang groups | 1.15±0.21* | 1.83±0.25* | 739.87±144.76 | 4.15±0.66* |
| Experimental group A | 0.96±0.17△* | 1.78±0.29* | 720.75±162.09 | 3.79±0.63* |
| Experimental group B | 0.75±0.13△* | 1.77±0.41* | 758.81±187.47 | 3.45±0.33* |
| Experimental group C | 1.12±0.12△* | 1.88±0.42* | 762.79±158.11 | 4.78±0.63* |
Note：Compare with high lipid food matched group, * P<0.05, compare with basic test portion group,△P<0.05.
From table 3 it is observed that each group free fatty is not statistically significant；T-CHOL, triacylglycerol and blood glucose
There is statistical significance.The Chinese medicine formula drug extract hyperlipemia rat for being applied to sluggishness of qi and phlegm hyperlipemia has significantly
Lipid-lowering effect, the effect of wherein experimental group A, B are substantially better than Wei Zhikang groups and experimental group C, and experimental group B is in triacylglycerol and blood
Experimental group A is substantially better than on sugared two indices.
Applicating expedition of the embodiment 3 in clinic
Modern many traditional Chinese medical science scholars think hyperlipidemia category " expectorant is turbid " category；Think such as Lee Cyprinus carpio, primary disease emphasis not in void, and
In diet Sorghum vulgare Pers. savoury, psychentonia, physical exertion is reduced, over-burden to cause taste, and the expectorant turbid interior birthday blocks venation expectorant long
Resistance blood stasis.
With retrospective case-control research method to using experimental group A and matched group (the commercially available dimension fat recovering capsule of administration,
Manufacturer：Nine days, Anshan, Chinese medicines quasi-word B20020695) 534 people carry out TCM Syndrome Theories investigation, it is found that expectorant is turbid in various excess syndromes
Blood, the stasis of blood and disorders of lipid metabolism are the closest.This is based on, we check the high fat of type with expelling phlegm and resolving turbidity activating blood circulation method is turbid to 120 expectorant
Mass formed by blood stasis patient has carried out clinical treatment, obtains satisfactory effect.
All patient is all from clinical research hospital outpatient and inpatient, meets Western medicine diagnostic criteria and Chinese medical discrimination
Person.Two groups are randomly divided into, experimental group A is each 60 with matched group, and patient keeps the living standard similar to before medication during treatment
With life style.The previous late fasting high fat diet and drinks special requirement for taking blood every time maintains complications Treatment medicine such as diabetes with polydipsia as the prominent symptom
Bitterly, nifedipine etc. then maintains tested front drug level.Comparative observation blood, urine, feces routine, Liver and kidney function before and after the course for the treatment of；Body weight becomes
Change and untoward reaction；TC、TG、H DL-C.Foundation defends planning commission's formulation《New Chinese medicine guideline of clinical investigations》Carry out curative effect
Assessment.As a result, the overall clinical efficacy rate of experimental group A is greatly to 95%, hence it is evident that better than matched group.
Claims (4)
1. a kind of Chinese medicine formula medicine suitable for sluggishness of qi and phlegm hyperlipemia, it is characterised in that：Described Chinese medicine formula medicine
The active component of thing is 6 by weight ratio:6:6:6:3:3 Bulbus Allii powder, Radix Salviae Miltiorrhizae, Fructus Crataegi, Pericarpium Citri Reticulatae, Flos Sophorae and Radix Notoginseng composition.
2. the Chinese medicine formula medicine suitable for sluggishness of qi and phlegm hyperlipemia according to claim 1, it is characterised in that：Institute
The preparation method for stating Chinese medicine formula medicine is comprised the following steps：
1. weight ratio according to claim 1 weighs medical material；
2. Radix Notoginseng and Pericarpium Citri Reticulatae are ground into fine powder；
3. Radix Salviae Miltiorrhizae, Fructus Crataegi and Flos Sophorae are added 60% alcohol reflux three times, every time plus 6 times of amounts of ethanol, reflux, extract, 2 hours, filter
Cross, merging filtrate obtains ethanol extract；
4., by ethanol extract under the conditions of 60 DEG C, reclaim ethanol and be concentrated into the clear paste that relative density is 1.10～1.14；
5. Radix Notoginseng powder is added in clear paste, mix, fully dry, pulverize under the conditions of 80 DEG C, add garlic powder tangerine peel powder, obtain
To the Chinese medicine formula medicine for being applied to sluggishness of qi and phlegm hyperlipemia.
3. the Chinese medicine formula medicine suitable for sluggishness of qi and phlegm hyperlipemia according to claim 1, it is characterised in that：Institute
The preparation method for stating Chinese medicine formula medicine is comprised the following steps：
1. weight ratio according to claim 1 weighs medical material；
2. Radix Notoginseng was ground into the granule of 20 mesh sieve, the ethanol with 40% starts percolation as solvent immersion more than 12h, oozes
Solvent consumption of filtering is 10 times of medical material weight, obtains Radix Notoginseng alcohol extract；
3., by Radix Notoginseng alcohol extract under the conditions of 50 DEG C, reclaim ethanol and to be concentrated into the Radix Notoginseng that relative density is 1.10～1.14 clear
Cream；
4. Pericarpium Citri Reticulatae, Radix Salviae Miltiorrhizae, Fructus Crataegi and Flos Sophorae are mixed, the ethanol with 70% starts percolation, percolation as solvent immersion more than 12h
Solvent consumption is 10 times of medical material weight, obtains mixing alcohol extract；
5. alcohol extract extract will be mixed under the conditions of 50 DEG C, ethanol is reclaimed and be simultaneously concentrated into the mixing that relative density is 1.10～1.14
Clear paste；
6. merge Radix Notoginseng clear paste and mixing clear paste, fully dry, pulverize under the conditions of 60 DEG C, add Bulbus Allii powder and tangerine peel powder, obtain
To the Chinese medicine formula medicine for being applied to sluggishness of qi and phlegm hyperlipemia.
4. a kind of capsule of the Chinese medicine formula medicine suitable for sluggishness of qi and phlegm hyperlipemia, it is characterised in that：Will by right
Ask the Chinese medicine formula medicine suitable for sluggishness of qi and phlegm hyperlipemia described in 2 or 3 any one directly encapsulated, per 750g active compounds
Material prepares 1000 capsules.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610833077.6A CN106491922B (en) | 2016-09-20 | 2016-09-20 | Traditional Chinese medicine formula medicine suitable for qi stagnation and turbid phlegm type hyperlipemia and capsule thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610833077.6A CN106491922B (en) | 2016-09-20 | 2016-09-20 | Traditional Chinese medicine formula medicine suitable for qi stagnation and turbid phlegm type hyperlipemia and capsule thereof |
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| Publication Number | Publication Date |
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| CN106491922A true CN106491922A (en) | 2017-03-15 |
| CN106491922B CN106491922B (en) | 2020-02-07 |
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| CN201610833077.6A Active CN106491922B (en) | 2016-09-20 | 2016-09-20 | Traditional Chinese medicine formula medicine suitable for qi stagnation and turbid phlegm type hyperlipemia and capsule thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115364166A (en) * | 2022-08-31 | 2022-11-22 | 重庆希尔安药业有限公司 | Preparation method of Wei Zhi kang capsules for improving process stability and product quality |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943702A (en) * | 2005-10-08 | 2007-04-11 | 周小明 | A Chinese traditional medicinal composition for treatment of hyperlipemia and its preparation method |
| CN101966214A (en) * | 2009-07-27 | 2011-02-09 | 天津天士力制药股份有限公司 | Panax notoginseng triol ginsenoside extract and preparation method thereof |
| CN105660773A (en) * | 2016-04-01 | 2016-06-15 | 冯恺 | Pizza base and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943702A (en) * | 2005-10-08 | 2007-04-11 | 周小明 | A Chinese traditional medicinal composition for treatment of hyperlipemia and its preparation method |
| CN101966214A (en) * | 2009-07-27 | 2011-02-09 | 天津天士力制药股份有限公司 | Panax notoginseng triol ginsenoside extract and preparation method thereof |
| CN105660773A (en) * | 2016-04-01 | 2016-06-15 | 冯恺 | Pizza base and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115364166A (en) * | 2022-08-31 | 2022-11-22 | 重庆希尔安药业有限公司 | Preparation method of Wei Zhi kang capsules for improving process stability and product quality |
| CN115364166B (en) * | 2022-08-31 | 2023-10-13 | 重庆希尔安药业有限公司 | Preparation method of Weizhikang capsules for improving process stability and product quality |
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| CN106491922B (en) | 2020-02-07 |
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