CN106491922B - Traditional Chinese medicine formula medicine suitable for qi stagnation and turbid phlegm type hyperlipemia and capsule thereof - Google Patents
Traditional Chinese medicine formula medicine suitable for qi stagnation and turbid phlegm type hyperlipemia and capsule thereof Download PDFInfo
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- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention provides a traditional Chinese medicine formula medicine suitable for qi stagnation and turbid phlegm type hyperlipemia, wherein active ingredients of the traditional Chinese medicine formula medicine consist of garlic powder, salvia miltiorrhiza, hawthorn, dried orange peel, sophora flower and pseudo-ginseng in a weight ratio of 6:6:6:6:3: 3; the traditional Chinese medicine formula medicine suitable for qi stagnation and phlegm turbidity type hyperlipemia provided by the invention has a good treatment effect on hyperlipemia.
Description
Technical Field
The invention relates to a traditional Chinese medicine composition for treating hyperlipidemia, and particularly relates to a traditional Chinese medicine formula medicine suitable for qi stagnation and turbid phlegm type hyperlipidemia and capsules thereof.
Technical Field
Hyperlipidemia refers to a condition in which one or more lipids in the plasma are higher than normal due to abnormal fat metabolism or movement. Hyperlipidemia is a primary risk factor of Atherosclerosis (AS), and with the acceleration of life rhythm and the change of dietary structure, the mortality rate caused by heart and brain diseases on the basis of AS is increasing. Hyperlipemia is a common disease and a frequently encountered disease, and has a very close relationship with cardiovascular and cerebrovascular diseases. Ameliorating dyslipidemia can prevent or reverse the progression of atherosclerotic lesions. Therefore, the lipid-lowering therapy plays an important role in the primary and secondary prevention of the coronary heart disease.
Hyperlipidemia is a disease name of modern medicine, traditional Chinese medicine does not have a corresponding disease name, is described in documents, and is scattered in records of symptoms such as fat, paste and meat of people, phlegm turbidity, chest obstruction and the like, for example, Lingshu Weiqi disorder. In the Zhongyun from Ling Shu & Wu addict body fluids differentiation, it is said that the combination of body fluids of five cereals and their combination into grease, which is infiltrated into the bone and the brain marrow and flows down to the yin thigh. Zhongyun from Zhangzhi Smart periodical Ling Shu Ji Zhu, wherein the qi of the middle jiao, steaming body fluid and liquefying, the fine overflow of the qi causes skin and meat to become fat, and the rest is the interior causes the skin and meat to become full of fat. Therefore, the term "grease" in traditional Chinese medicine refers to "blood fat". Meanwhile, it is also indicated that grease is one of the physiological components of human body, and belongs to the category of body fluid, and can be transformed with other components of body fluid. Fluid turns into paste from turbid, and grease from congealing. It is originated from food essence, and is applied by the spleen and stomach to circulate the blood vessels up and down, so as to nourish the whole body, moisten and nourish the internal organs, limbs and bones, and has the functions of injecting bone void, nourishing brain and marrow, and moistening skin. When the transfer and excretion of grease in the body become abnormal, it turns into pathological phlegm-turbid dampness, which is then infused into blood vessels to cause hyperlipidemia.
Hyperlipidemia is pathological grease, which is turbid phlegm in blood. Phlegm is similar to fluid retention and different in name. Thick and turbid are phlegm, clear and thin are fluid, for example, in Zhongyun from Zhangjing, Rusjing and Yue quan Shu-phlegm fluid, the transformation of phlegm and saliva is caused by food, so that the fruit spleen strengthens the stomach and the spleen is strong as if the young and strong are flowing, and the qi and blood are transformed along with food, so that the qi and blood are remained as phlegm, only the qi and the blood are transformed into eleven, one is , and the thirteen and the fourteen are .
Disclosure of Invention
In order to solve the problems, the invention provides a traditional Chinese medicine formula medicine suitable for qi stagnation and turbid phlegm type hyperlipemia, and active ingredients of the traditional Chinese medicine formula medicine comprise garlic powder, salvia miltiorrhiza, hawthorn, dried orange peel, sophora flower and pseudo-ginseng in a weight ratio of 6:6:6:6:3: 3.
The preparation method of the traditional Chinese medicine formula medicine comprises the following steps:
① weighing the raw materials according to the weight ratio;
② pulverizing radix Notoginseng and pericarpium Citri Reticulatae to get fine powder;
③ reflux-extracting radix Salviae Miltiorrhizae, fructus crataegi, and flos Sophorae with 60% ethanol for three times, each time with 6 times of ethanol, for 2 hr, filtering, and mixing filtrates to obtain ethanol extract;
④ recovering ethanol from the ethanol extract at 60 deg.C, and concentrating to obtain fluid extract with relative density of 1.10-1.14;
⑤ adding radix Notoginseng powder into the fluid extract, mixing, drying at 80 deg.C, pulverizing, and adding Bulbus Allii powder pericarpium Citri Reticulatae powder to obtain the Chinese medicinal composition for treating qi stagnation and phlegm turbidity type hyperlipidemia.
Another preparation method of the traditional Chinese medicine formula medicine comprises the following steps:
① weighing the raw materials according to the weight ratio;
② pulverizing radix Notoginseng into granules, sieving with 20 mesh sieve, soaking in 40% ethanol for more than 12 hr, and percolating to obtain radix Notoginseng ethanol extractive solution with the use amount of percolating solvent 10 times of the weight of the raw materials;
③ recovering ethanol from the ethanol extractive solution of radix Notoginseng at 50 deg.C, and concentrating to obtain radix Notoginseng fluid extract with relative density of 1.10-1.14;
④ mixing pericarpium Citri Reticulatae, radix Salviae Miltiorrhizae, fructus crataegi, and flos Sophorae, soaking in 70% ethanol for more than 12h, and percolating to obtain mixed ethanol extractive solution with the amount of percolating solvent 10 times of the weight of the raw materials;
⑤ recovering ethanol from the mixed ethanol extractive solution at 50 deg.C, and concentrating to obtain mixed fluid extract with relative density of 1.10-1.14;
⑥ mixing the radix Notoginseng fluid extract and the mixed fluid extract, drying at 60 deg.C, pulverizing, and adding Bulbus Allii powder to obtain traditional Chinese medicine formula medicine suitable for qi stagnation and phlegm turbidity type hyperlipidemia.
The traditional Chinese medicine formula medicine suitable for qi stagnation and phlegm turbidity type hyperlipemia is directly filled into capsules, and 1000 capsules are prepared from 750g of raw medicinal materials.
The beneficial technical effects of the invention are as follows: the traditional Chinese medicine formula medicine suitable for qi stagnation and phlegm turbidity type hyperlipemia provided by the invention has a good treatment effect on hyperlipemia.
Detailed Description
EXAMPLE 1 preparation of test samples
1. A process for preparing garlic powder includes such steps as choosing the garlic cloves which are harvested, removing the pests or damage to garlic cloves, washing in clean water, peeling, immersing in cold water for 1 hr, removing peel, taking out, draining residual water, and beating ③ by beater or pulverizer while adding 1/3-g water, beating, filtering by coarse gauze, removing residual peel, centrifugal separation, removing water, washing ④ at 12000 rpm, baking at 50 deg.C.
2. Weighing 150g of garlic powder, 150g of salvia miltiorrhiza, 150g of hawthorn, 150g of dried orange peel, 75g of sophora flower and 75g of pseudo-ginseng, and crushing the pseudo-ginseng and the dried orange peel into fine powder except the garlic powder. Taking three medicines of salvia miltiorrhiza, hawthorn and sophora flower, adding 60% ethanol for reflux extraction for three times, adding 6 times of 60% ethanol for each time, reflux extraction for 2 hours, filtering, combining filtrates, recovering ethanol, and concentrating to obtain clear paste with the relative density of 1.10-1.14 (60 ℃). Mixing Notoginseng radix powder and fluid extract, drying (80 deg.C), pulverizing, adding Bulbus Allii powder and pericarpium Citri Tangerinae powder, and mixing to obtain traditional Chinese medicine formula medicine for qi stagnation and phlegm turbidity type hyperlipidemia, as experimental group A.
3. Weighing 150g of garlic powder, 150g of salvia miltiorrhiza, 150g of hawthorn, 150g of dried orange peel, 75g of sophora flower and 75g of pseudo-ginseng, crushing the pseudo-ginseng into particles which are sieved by a 20-mesh sieve, soaking the particles for more than 12 hours by using 40% ethanol as a solvent, and starting percolation, wherein the dosage of the percolation solvent is 10 times of the weight of the medicinal materials, so as to obtain pseudo-ginseng alcohol extract; recovering ethanol from the panax notoginseng ethanol extract at 50 ℃, and concentrating to obtain panax notoginseng clear paste with the relative density of 1.10-1.14; mixing pericarpium Citri Tangerinae, Saviae Miltiorrhizae radix, fructus crataegi and flos Sophorae Immaturus, soaking with 70% ethanol as solvent for more than 12 hr, and percolating to obtain mixed ethanol extractive solution with the use amount of percolating solvent 10 times of the weight of the medicinal materials; recovering ethanol from the mixed ethanol extract at 50 ℃, and concentrating to obtain mixed clear paste with the relative density of 1.10-1.14; mixing Notoginseng radix fluid extract and mixed fluid extract, drying at 60 deg.C, pulverizing, and adding Bulbus Allii powder to obtain traditional Chinese medicine formula medicine suitable for qi stagnation and phlegm turbidity type hyperlipidemia, as experimental group B.
4. Weighing 150g of garlic powder, 150g of salvia miltiorrhiza, 150g of hawthorn, 150g of dried orange peel, 75g of sophora flower and 75g of pseudo-ginseng, and crushing the pseudo-ginseng into particles which are sieved by a 20-mesh sieve for later use; mixing pseudo-ginseng powder, dried orange peel, salvia miltiorrhiza, hawthorn and sophora flower, adding water for reflux extraction for three times, adding 6 times of water for each time, reflux extraction for 2 hours, filtering, combining filtrates, recovering and concentrating to obtain clear paste with the relative density of 1.10-1.14 (60 ℃). Mixing Notoginseng radix powder and fluid extract, drying (80 deg.C), pulverizing, adding Bulbus Allii powder, and mixing to obtain traditional Chinese medicine formula medicine for qi stagnation and phlegm turbidity type hyperlipidemia as experimental group C.
Example 2 Activity study of a traditional Chinese medicine formulation suitable for qi-stagnation and turbid phlegm-type hyperlipemia
The rats are randomly divided into 6 groups according to body mass, 8 rats in a chitosan group, a vitamin fat recovery group (vitamin fat recovery capsule, manufacturer: Chongqing Hieran pharmaceutical industry Co., Ltd., national standard B20160002), an experimental group A, an experimental group B, an experimental group C, a high-fat feed control group and a basal feed control group respectively feed basic feed to rats in the basal feed control group, high-fat feed diet to rats in other groups, the rats in the chitosan group, the vitamin fat recovery group, the experimental group A, the experimental group B and the experimental group C are respectively fed with 100 mg/kg of chitosan and 15 g/kg of the vitamin fat recovery group through stomach filling, 15g of crude drug/kg. crude drug in the experimental group A, the experimental group B and the experimental group C prepared in example 1 are respectively fed with distilled water through stomach filling, the stomach has a volume of 20ml/kg,1 time/d, the rats are respectively fed with crude drug for 4 weeks, 1 time of body mass is collected at the end of a continuous period, the feces content in a continuous period 3d is respectively collected, the rats are respectively, and the feces content in a serum weight change of the rats in a blood sample is measured by a blood glucose-fat-glucose-.
Table 1 body weight mass and weight gain of rats in each group after four weeks feeding (n ═ 8, g)
Note: p compared to high-fat diet control group<0.05, compared with the control of the basic sample group,△P<0.05。
as shown in table 1, after feeding for 4 weeks, the body mass and weight gain of rats in the high-fat feed control group are significantly higher than those in the basal feed control group (P <0.05), and the body mass and weight gain of rats in the traditional Chinese medicine formula group, the Weizhikang group and the chitosan group suitable for the qi stagnation and turbid phlegm type hyperlipidemia are significantly lower than those in the high-fat feed control group (P <0.05), wherein the experimental group B has a significant effect in controlling the body weight of rats, which indicates that the traditional Chinese medicine formula medicine suitable for the qi stagnation and turbid phlegm type hyperlipidemia can reduce the body mass and slow down the body mass growth. The weight gain of the rat with the traditional Chinese medicine formula medicine extract suitable for qi stagnation and phlegm turbidity type hyperlipemia is smaller than that of each test object used singly, but the difference has no significant significance (P is more than 0.05).
The blood chemistry changes of the rats in each group after 4 weeks of feeding are shown in table 2.
TABLE 2 comparison of blood biochemical parameters of various groups of rats after four weeks feeding: (
n＝8)
| Group of | Triacylglycerols (nmol/L) | Total cholesterol (nmol/L) | Free fatty acid (nmol/L) | Blood sugar (nmol/L) |
| High fat feed control group | 2.41±1.16* | 2.76±0.46 | 759.91±115.09 | 6.95±0.48 |
| Basal feed control group | 1.32±0.40 | 1.58±0.21* | 704.81±167.75 | 4.23±0.52* |
| Chitosan group | 1.16±0.44* | 2.25±0.57 | 739.81±191.20 | 3.79±0.85* |
| Weizhikang group | 1.15±0.21* | 1.83±0.25* | 739.87±144.76 | 4.15±0.66* |
| Experimental group A | 0.96±0.17△* | 1.78±0.29* | 720.75±162.09 | 3.79±0.63* |
| Experimental group B | 0.75±0.13△* | 1.77±0.41* | 758.81±187.47 | 3.45±0.33* |
| Experimental group C | 1.12±0.12△* | 1.88±0.42* | 762.79±158.11 | 4.78±0.63* |
Note: p compared to high-fat diet control group<0.05, compared with the control of the basic sample group,△P<0.05。
as can be seen from table 3, the free fatty acids of each group have no statistical significance; total cholesterol, triacylglycerol, and blood glucose have statistical significance. The traditional Chinese medicine formula medicine extract hyperlipemia rats suitable for qi stagnation and phlegm turbidity type hyperlipemia have obvious blood fat reducing effect, wherein the effect of the experimental group A, B is obviously superior to that of the Wei Zhi kang group and the experimental group C, and the experimental group B is obviously superior to that of the experimental group A in two indexes of triacylglycerol and blood sugar.
Example 3 examination of clinical applications
Modern Chinese medical researchers think that hyperlipidemia belongs to the category of turbid phlegm; for example, Li carp considers that the disease is not mainly deficient, but is caused by excessive burden of spleen and stomach due to thick sorghum, mental stress and reduced physical activity, and vein phlegm obstruction and blood stasis due to long-term generation of turbid phlegm in the interior.
The retrospective case contrast research method is used to conduct traditional Chinese medicine syndrome-climatological investigation on 534 people using the experimental group A and the control group (the product is the Weizhikang capsule sold in the market, the manufacturer: Anshan for nine days, the national standard of medicine B20020695) to find that turbid phlegm blood, stasis and lipid metabolism disorder are the most closely among various excess syndromes. Based on the above, the clinical treatment is carried out on 120 patients with the phlegm-turbidity-blocking-type hyperlipemia by using the phlegm-eliminating, turbidity-resolving and blood-activating method, and a satisfactory curative effect is obtained.
All patients come from outpatients and inpatients of clinical research hospitals and meet the diagnosis standard of western medicine and Chinese medicine syndrome differentiation. The treatment period of the patients is similar to the life level and life style before taking the medicine. The former night of fasting high fat diet and alcoholic drink for each blood taking needs to maintain the drug level before the test if the treatment drugs for complicating diseases such as heart pain and cardiodynia are maintained. The routine observation of blood, urine and stool, and the function of liver and kidney before and after the treatment course; weight change and adverse reactions; TC, TG, H DL-C. The evaluation of the curative effect is carried out according to the clinical research guiding principle of new traditional Chinese medicine made by Wei Ji Wei. As a result, the total clinical effective rate of the experimental group A is as high as 95 percent, which is obviously superior to that of the control group.
Claims (2)
1. A traditional Chinese medicine formula medicine suitable for qi stagnation and phlegm turbidity type hyperlipemia is characterized in that: the active ingredients of the traditional Chinese medicine formula medicine consist of garlic powder, salvia miltiorrhiza, hawthorn, dried orange peel, sophora flower and pseudo-ginseng in a weight ratio of 6:6:6:6:3: 3; the preparation method of the traditional Chinese medicine formula medicine comprises the following steps:
① weighing the raw materials according to the weight ratio;
② pulverizing radix Notoginseng into granules, sieving with 20 mesh sieve, soaking in 40% ethanol for more than 12 hr, and percolating to obtain radix Notoginseng ethanol extractive solution with the use amount of percolating solvent 10 times of the weight of the raw materials;
③ recovering ethanol from the ethanol extractive solution of radix Notoginseng at 50 deg.C, and concentrating to obtain radix Notoginseng fluid extract with relative density of 1.10-1.14;
④ mixing pericarpium Citri Reticulatae, radix Salviae Miltiorrhizae, fructus crataegi, and flos Sophorae, soaking in 70% ethanol for more than 12h, and percolating to obtain mixed ethanol extractive solution with the amount of percolating solvent 10 times of the weight of the raw materials;
⑤ recovering ethanol from the mixed ethanol extractive solution at 50 deg.C, and concentrating to obtain mixed fluid extract with relative density of 1.10-1.14;
⑥ mixing the radix Notoginseng fluid extract and the mixed fluid extract, drying at 60 deg.C, pulverizing, and adding Bulbus Allii powder to obtain traditional Chinese medicine formula medicine suitable for qi stagnation and phlegm turbidity type hyperlipidemia.
2. A capsule of traditional Chinese medicine prescription medicine suitable for qi stagnation and phlegm turbidity type hyperlipemia is characterized in that: the traditional Chinese medicine formula medicine suitable for qi stagnation and phlegm turbidity type hyperlipemia of claim 1 is directly filled into capsules, and 1000 capsules are prepared from 750g of raw medicinal materials.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943702A (en) * | 2005-10-08 | 2007-04-11 | 周小明 | A Chinese traditional medicinal composition for treatment of hyperlipemia and its preparation method |
| CN101966214A (en) * | 2009-07-27 | 2011-02-09 | 天津天士力制药股份有限公司 | Panax notoginseng triol ginsenoside extract and preparation method thereof |
| CN105660773A (en) * | 2016-04-01 | 2016-06-15 | 冯恺 | Pizza base and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943702A (en) * | 2005-10-08 | 2007-04-11 | 周小明 | A Chinese traditional medicinal composition for treatment of hyperlipemia and its preparation method |
| CN101966214A (en) * | 2009-07-27 | 2011-02-09 | 天津天士力制药股份有限公司 | Panax notoginseng triol ginsenoside extract and preparation method thereof |
| CN105660773A (en) * | 2016-04-01 | 2016-06-15 | 冯恺 | Pizza base and preparation method thereof |
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