CN106489960A

CN106489960A - Pesticidal combination containing afidopyropen and cycloxaprid

Info

Publication number: CN106489960A
Application number: CN201610903165.9A
Authority: CN
Inventors: 王景阳; 李达忠; 李次平; 叶宇平; 杨建江
Original assignee: Foshan Yinghui Crop Science Co Ltd
Current assignee: Foshan Yinghui Crop Science Co Ltd
Priority date: 2016-10-17
Filing date: 2016-10-17
Publication date: 2017-03-15

Abstract

The present invention relates to the Pesticidal combination of a kind of afidopyropen and cycloxaprid, the weight ratio of two kinds of active ingredients is 1:20～20:1, the total mass percent content of active ingredient in Pesticidal combination is 1%～90%, remaining is to allow to use and acceptable auxiliary element in agricultural chemicals, can be prepared into wettable powder, suspending agent, aqueous emulsion, microemulsion, missible oil, suspension emulsion, water dispersible granules, microcapsule suspending agent, solvable pulvis, soluble granule.The composition of the present invention has obvious synergy crop, it is possible to decrease the utilization rate of agricultural chemicals, and residues of pesticides are low and easy decomposition, more environmentally-friendly, are a kind of environmentally friendly highly effective pesticides.

Description

Pesticidal combination containing afidopyropen and cycloxaprid

Technical field

The present invention relates to composition pesticide field, and in particular to be a kind of agriculture containing afidopyropen and cycloxaprid Medicine Pesticidal combination.

Background technology

Afidopyropen is a kind of new of Japanese Meiji Pharmaceutial Ltd. and Japanese Kitasato Kenkyusho's joint development Insecticide, with brand-new mechanism of action, is respectively provided with cause well to sucking pest such as aphid, plant hopper, scale insect and leafhopper Dead effect, can be used for vegetables, fruit tree, imtertilled crop and ornamental plant etc., and either foliar treatment, plantation is processed at still soil Reason all has good effect, and toxicity is very low.

Cycloxaprid（cycloxaprid）It is to be combined out by East China University of Science and Shengnong Biological-Chemical Products Co., Ltd., Shanghai A kind of cis oxygen bridge heterocycle structure anabasine insecticide with independent intellectual property right that sends out.Its structural formula is：

.

Cycloxaprid double wing purpose planthopper (brown paddy plant hopper, white backed planthopper, small brown rice planthopper), aphid (wheat aphid, cotten aphid, clover Aphid, cabbage aphid) etc. insect have high insecticidal activity, have one to Lepidoptera class pest such as rice leaf roller, armyworm and diamondback moth etc. Fixed insecticidal effect.Therefore, cycloxaprid may be used primarily for the preventing and treating of Hemipteran pest such as planthopper, aphid, Bemisia tabaci etc..By In its unique mechanism of action, cycloxaprid is to indoor anti-Diacloden Type B Bemisia tabaci adults, anti-imidacloprid brown paddy plant hopper, anti-pyrrole worm B the and Q type Bemisia tabacis of quinoline have significant high activity, to natural enemies securities such as ladybug, spider, ground beetle and dragonflies.

In the real process of agricultural production, the maximally efficient means that chemical agent is preventing and treating plant pest are applied, but It is to be easiest to generate the problem that the drug-fast generation of insect pest by chemical prevention insect pest.Practical application proves, agricultural chemicals single dose pair Pest control effect is gradually reduced, and some pesticide activity component compoundings can reach raising drug effect, and delays the insect pest resistance to the action of a drug Generation.We screen indoors and on the basis of field test, filter out afidopyropen and cycloxaprid is compounded, There is obvious synergistic effect；And it is current still with regard to the composition pesticide and application of afidopyropen and the compounding of cycloxaprid Do not reported.

Content of the invention

It is an object of the invention to being not enough for prior art, there is provided a kind of applied widely, low cost, effect are good, The Pesticidal combination of the afidopyropen and cycloxaprid of plant resistance problems can be solved.

The present invention is achieved by the following technical programs：

A kind of Pesticidal combination containing afidopyropen and cycloxaprid, it is characterised in that including the first active component（A） Afidopyropen, the second active component cycloxaprid（B）, active components A is 1 with active component B preferred weight ratios:50～ 50:1, more preferably 1:20～20:1；The accumulation of the first active component and the second active component in the Pesticidal combination of the present invention Amount（Weight add and）For the 1%～90% of said composition gross weight, preferably 2%-60%.

The Pesticidal combination is re-dubbed the formulation that allow on agricultural chemicals with known auxiliary agent and excipient：It can for example be breast Oil, wettable powder, water dispersible granules, suspending agent, aqueous emulsion, suspension emulsion, microemulsion, dispersible oil-suspending agent, microcapsule suspension In agent, solvable pulvis any one.

In the Pesticidal combination of the present invention, two kinds of active ingredients show obvious synergistic effect, to Brown Planthopper, in vain Backward flight lice and rice leaf roller prevention effect significantly, show excellent quick-acting and lasting effect, overcome each single dose Shortcoming.

Compared with prior art, the present invention has following beneficial effect：（1）Compared with single dose, the combination to Brown Planthopper, The synergy of the insect such as white backed planthopper, rice leaf roller substantially, overcomes and has delayed the resistance to the action of a drug, expands preventing and treating spectrum, improves anti- Control effect；（2）Reduce preventing and treating recruitment, drug cost；（3）Alternative conventional medicine and the easily agricultural chemicals of generation resistance；（4）With list Agent is compared, and two kinds of single dose combinations can reduce application cost.

Specific embodiment

In order that the objects, technical solutions and advantages of the present invention become more apparent, present invention specific examples below Illustrate, but the present invention is limited to absolutely not these examples.Described below is only the present invention preferably embodiment, is used only for explaining The present invention, but can not be therefore understands that being the restriction to the scope of the claims of the present invention.It should be pointed out that all the present invention spirit and Any modification, equivalent or improvement for being made within principle etc., should be included within the scope of the present invention, therefore, The protection domain of patent of the present invention should be defined by claims.

First, example of formulations

1st, embodiment 1：51%afidopyropen cycloxaprid suspending agents

afidopyropen 1%

Cycloxaprid 50%

AEO 1.5%

EO-PO block polyethers 1.5%

Alkylnaphthalene sulfonate 4%

Xanthans 0.1%

Propane diols 4%

Defoamer 0.1%

Water polishing is to 100%

The concrete procedure of processing of said composition suspending agent is：By in above-mentioned formula by water and wetting agent, dispersant, thickener, anti- Freeze agent and defoamer mixing, be well mixed through high speed shear, add afidopyropen, cycloxaprid, continue shearing and mix, Subsequently in horizontal sand mill grind, make preparation particle diameter all in below 5UM, be obtained of the present invention containing Afidopyropen, the suspending agent of cycloxaprid.

2nd, embodiment 2：21%afidopyropen cycloxaprid water dispersible granules (1:20)

afidopyropen 1%

Cycloxaprid 20%

Neopelex 3%

The formaldehyde condensation products 6% of methyl naphthalene sulfonic acid sodium

Sodium carboxymethyl starch 2%

White carbon polishing is to 100%

The concrete procedure of processing of said composition water dispersible granules is：And divide afidopyropen, cycloxaprid by above-mentioned formula Powder, wetting agent, disintegrant and filler are well mixed, and are crushed with micro jet, through mediating, make subsequently into extruding Grain machine granulation, in boiling drier dry, through sample analysis after screening, be obtained of the present invention containing afidopyropen, The water dispersible granules of cycloxaprid.

3rd, embodiment 3：12%afidopyropen cycloxaprid suspension emulsions

afidopyropen 2%

Cycloxaprid 10%

Fatty acid methyl ester 15%

AEO 2%

EO-PO block polyethers 2%

Alkyl phenol alcohol ether phosphate 4%

Xanthans 0.1%

Propane diols 4%

Defoamer 0.1%

Water polishing is to 100%

The concrete procedure of processing of said composition suspension emulsion is：Afidopyropen and fatty acid methyl ester are mixed by above-mentioned formula Stirring, adds the mixing of alkyl phenol alcohol ether phosphate, adds suitable water under stirring condition after dissolving completely, open when closing on phase inversion point Cutter, disperses at a high speed afidopyropen EW parts are obtained；By in above-mentioned formula by wetting agent, dispersant, antifreezing agent, disappear Infusion, suitable water mixing and stirring, add cycloxaprid, continue shearing and mix, grind subsequently in horizontal sand mill, make Particle diameter is all obtained SC parts in below 5um, and proceeds to above-mentioned afidopyropen EW parts, and shearing is mixed, and the present invention is obtained The described suspension emulsion containing afidopyropen and cycloxaprid.

4th, embodiment 4：2%afidopyropen cycloxaprid microemulsions

afidopyropen 1%

Cycloxaprid 1%

1-METHYLPYRROLIDONE 5%

Cyclohexanone 8%

Calcium dodecyl benzene sulfonate 5%

Styryl phenol polyethenoxy ether 10%

Water polishing is to 100%

The concrete procedure of processing of said composition microemulsion is：Above-mentioned formula is pressed by afidopyropen, cycloxaprid N- methyl After pyrrolidones and cyclohexanone are completely dissolved, add other auxiliary agents to be well mixed, be eventually adding water and be sufficiently stirred for.Can be prepared by this The described microemulsion containing afidopyropen and cycloxaprid of invention

5th, embodiment 5：10%afidopyropen cycloxaprid microcapsule suspending agents

afidopyropen 6%

Cycloxaprid 4%

Toluene di-isocyanate(TDI) 3%

Hexamethylene diamine 2%

Solvent naphtha 10%

Dodecyl decyl amide 10%

Castor oil polyoxyethylene ether 5%

Sodium methylene bis-naphthalene sulfonate 3%

Water polishing is to 100%

The concrete procedure of processing of said composition microcapsule suspending agent is：Above-mentioned formula is pressed by afidopyropen and cycloxaprid, oil Soluble monomers, solvent mixing, be dissolved into homogeneous oil phase, in a shear condition, by oil phase be added to containing emulsifying agent, dispersant, In the aqueous phase solution of water-soluble monomer, add citric acid and adjust PH to 6.5, surplus is supplied with water, and bi-material is in profit circle Face reacts, and forms high score ascus wall, you can the micro-capsule containing afidopyropen and cycloxaprid of the present invention is obtained Suspending agent.

6th, embodiment 6：12%afidopyropen cycloxaprid missible oil

afidopyropen 10%

Cycloxaprid 2%

1-METHYLPYRROLIDONE 8%

Calcium dodecyl benzene sulfonate 4%

Styryl phenol polyoxyethylene polyoxypropylene ether 7%

Sec-butyl acetate polishing is to 100%

The concrete procedure of processing of said composition missible oil is：Above-mentioned formula is pressed by afidopyropen, cycloxaprid N methylpyrroles Alkanone, sec-butyl acetate fully dissolve, and add other auxiliary agents to stir, you can be obtained of the present invention containing Afidopyropen and the missible oil of cycloxaprid.

7th, embodiment 7：21%afidopyropen cycloxaprids dispersible oil-suspending agent

afidopyropen 20%

Cycloxaprid 1%

AEO 5%

Crodaret 20%

Organobentonite 1%

Mineral oil polishing is to 100%

Said composition dispersibles the concrete procedure of processing of oil-suspending agent：Above-mentioned formula is pressed by mineral oil, afidopyropen, ring Oxygen worm pyridine, dispersant, thickener, emulsifying agent mixing, are well mixed through high speed shear, grind subsequently in horizontal sand mill, Make preparation particle diameter all in below 10um, be obtained and of the present invention dispersible oil containing afidopyropen and cycloxaprid Suspending agent.

8th, embodiment 8：51%afidopyropen cycloxaprid wettable powders

afidopyropen 50%

Cycloxaprid 1%

Alkylnaphthalene sulfonate 2%

Sodium lignin sulfonate 5%

White carbon polishing is to 100%

The concrete procedure of processing of said composition wettable powder is：By above-mentioned formula by afidopyropen, cycloxaprid and The mixing of dispersant, wetting agent and filler, uniform stirring in stirred tank are well mixed after air-flow crushing, you can this is obtained The bright described wettable powder containing afidopyropen and cycloxaprid.

2nd, biologicall test example

1st, Toxicity Determination

For understanding afidopyropen and definite virulence of the cycloxaprid mixture composition to brown paddy plant hopper, indoor virulence survey is first passed through Fixed its proportioning is screened, clear and definite two kinds of medicaments compound by a certain percentage after co-toxicity coefficient（CTC）, CTC ＜ 80 are Antagonism, 80≤CTC≤120 are summation action, and CTC ＞ 120 are synergistic effect.

Concrete test method：The mother liquor of each mixed agent is diluted to five series concentrations respectively, is respectively placed in standby in beaker With.Using the method that first leaching leaf is followed by worm, the blade of the same size not in contact with any medicament is put in the liquid for having configured Immersion 5s, dries after taking-up naturally, is put in insect box, then connects for examination nymph, raises under the conditions of 26 DEG C, each process Be repeated 3 times, repeat test worm number used every time for 50, while setting blank, after 72h, check dead borer population, calculate the death rate and Corrected mortality, tries to achieve virulence regression equation and calculates LC₅₀Value.If the control death rate is considered as invalid test more than 10%.Meter Calculate formula as follows：

The death rate（%）=（Borer population living after borer population medicine living before medicine）Borer population × 100 living before/medicine

Corrected mortality（%）=（The treatment group mortality rate control group death rate）/（The 1 control group death rate）×100

Insect corrected mortality is converted into probit value（y）, concentration for the treatment of（μg/ml）It is converted into logarithm value（x）, with least square Method draws virulence regression equation, and thus calculates the LC of every kind of medicament₅₀Value.Co-toxicity coefficient is calculated according to the abundant equations of Sun Yun CTC.Computing formula is as follows（With afidopyropen as standard agent, its toxicity index is 100）：

The toxicity index of cycloxaprid（TI）The LC of=afidopyropen₅₀The LC of cycloxaprid₅₀×100

The actual toxicity index of M（ATI）The LC of=afidopyropen₅₀The LC of M₅₀×100

The theoretical toxicity index of M（TTI）TI × the P of=afidopyropen_afidopyropenTI × the P of+cycloxaprid_Cycloxaprid

Co-toxicity coefficient（CTC）TTI × 100 of the ATI M of=M

In formula：M is the mixture of afidopyropen and cycloxaprid different ratio

P_CycloxapridFor the shared ratio in mixture of cycloxaprid

P_AfidopyropenFor the shared ratios in mixture of afidopyropen

For trying insect：Brown paddy plant hopper

Experiment reagent is provided by Foshan Brightmart Crop Science Co., Ltd..Experimental design：Determine through pilot study Afidopyropen and cycloxaprid active compound and effective lethasl concentration scope of the two different ratio mixture.Result of the test is as follows Table：

As shown in Table 1, the Toxicity Determination of afidopyropen and cycloxaprid compounding to brown paddy plant hopper, co-toxicity coefficient are all higher than 120, the i.e. present composition have preferable synergistic function, and its effect is better than single dose.

2nd, field control effectiveness test

Experiment process：This experiment separately designs two dosings according to the difference of each composition, and dosing is active ingredient The quality of afidopyropen and cycloxaprid and.Comparison medicament is that 20%afidopyropen suspending agents and 25% cycloxaprid can WP and blank clean water experiment.

Test method：Each plot area is 66.7m², it is repeated 3 times；Investigation drug effect side after investigating and prevent and treat before dispenser Method is, 5 points of grab sample in the test process area, carries out severity Scaling according to national field test relevant criterion, calculates preventive effect. Result of the test such as following table：

From table 2, field control effectiveness test result shows, effectively can prevent harnessing the river after afidopyropen and cycloxaprid compounding Rice pest, the composition of the present invention have obvious synergistic function, and prevention effect is better than single dose, and preventive effect phase is long；Real It is 3 to apply afidopyropen and cycloxaprid proportioning in example 5:When 2, preventive effect can reach more than 90%, and preventive effect is optimal；In examination Test and paddy rice is had no adverse effects in scope of medication, be worth popularization and application in agricultural production.

Claims

1. a kind of Pesticidal combination, it is characterised in that active component includes afidopyropen and cycloxaprid.

2. Pesticidal combination according to claim 1, it is characterised in that the weight of the afidopyropen and cycloxaprid Amount is than being 1:50～50:1.

3. described Pesticidal combination is required according to any one of claim 1～2, it is characterised in that described The weight ratio preferably 1 of afidopyropen and cycloxaprid:20～20:14.

4. described Pesticidal combination is required according to any one of claims 1 to 3, it is characterised in that the Pesticidal combination It is aided with insecticidal preparation processing auxiliary element and is processed into any one formulation for being suitable for agriculturally using.

5. Pesticidal combination according to claim 4, it is characterised in that the formulation of the Pesticidal combination is wettable powder Agent, suspending agent, aqueous emulsion, microemulsion, missible oil, suspension emulsion, microcapsule suspending agent, water dispersible granules, solvable pulvis, in soluble granule Any one.

6. Pesticidal combination according to any one of Claims 1 to 5 claim is used for the use for preventing and kill off crop pests On the way.

7. purposes according to claim 6, it is characterised in that the crop pests be preferably brown paddy plant hopper, white backed planthopper, Rice leaf roller.