CN106474525A - A kind of novel antibacterial hemostatic gauze and preparation method thereof - Google Patents
A kind of novel antibacterial hemostatic gauze and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
Abstract
Present invention relates particularly to a kind of novel antibacterial hemostatic gauze and preparation method thereof, the preparation method includes that medical absorbent cotton gauze is the modification such as are washed through alkalization, etherificate, neutralization and alcohol obtains sanlose gauze；Sanlose gauze is again through certain building-up process（Ion exchange）Obtain carboxyalkylcellulose metal salt gauze.Carboxyalkylcellulose metal salt gauze obtained by the present invention not only has hemostatic function but also with excellent anti-microbial property, it is not required to add hemostasis, anti-inflammatory rapidly by any medicine, surgical adhesions are also prevented from, final products resolve into monose in vivo and are absorbed by the body.
Description
Technical field
The present invention relates to medical instruments field, and in particular to a kind of novel antibacterial hemostatic gauze and preparation method thereof.
Background technology
According to statistics, the principal element for causing death on battlefield is excessive blood loss, accounts for the 50% or so of sum, and in peace
In period, because in the dead people of wound, 39% dies from excessive blood loss, the bleeding not being effectively controlled has been the second of died of wounds
Big leading factor.Even if bleeding gradually can be controlled in a long time, excessive losing blood also would generally cause the wounded's surface of a wound
The serious consequences such as infection, hypothermia, coagulation disorders or multiple organ's exhaustion.
Existing hemostatic material is typically difficult to have antibacterial functions concurrently, most of hemostatic material in order to antibacterial functions, typically
Antibacterials will be added, but so there is antibacterials problem of resistance.Therefore, one kind have concurrently hemostasis and antibacterial functions and
Do not use the medical supplies of antibacterials better meet the use demand of clinical treatment.
Content of the invention
The present invention proposes a kind of novel antibacterial hemostatic gauze and its preparation side for disadvantages mentioned above present in prior art
Method, its feature are that the modifications such as medical absorbent cotton gauze process alkalizes, is etherified, neutralizing and alcohol is washed obtain carboxymethylcellulose calcium
Sodium salt gauze；Sanlose gauze is again through certain building-up process（Ion exchange）Obtain novel antibacterial hemostatic yarn
Cloth.The novel antibacterial hemostatic gauze of the present invention not only has excellent hemostatic function but also with excellent anti-microbial property, is not required to add
Plus any medicine can rapidly hemostasis, anti-inflammatory, be also prevented from surgical adhesions, final products resolve into monose in vivo and by people
Body absorbs.
A kind of novel antibacterial hemostatic gauze provided by the present invention, the novel antibacterial hemostatic gauze main component are carboxylic first
Base cellulose metal salt, the carboxyalkylcellulose metal salt are sodium carboxymethylcellulose, calcium carboxymethylcellulose and carboxymethyl
Cellulose zinc.
Further, a kind of preparation method of novel antibacterial hemostatic gauze, comprises the following steps：
S1:Pretreatment:By medical absorbent cotton gauze soaked in absolute ethyl alcohol 30min-60min, (optimal pretreatment time is
30min)；Can be prevented because causing gauze shrinkage with alkaline reaction with absolute ethyl alcohol pretreatment.
S2:Basification:Medical absorbent cotton gauze after processing through S1 is immersed in the mixed solution of ethanol and alkali（v/
v=1:1）Quaternization is carried out, with 3:100-3:50 mass ratio is at 25 DEG C -30 DEG C（Optimal alkalization temperature is 30 DEG C）Temperature
Lower reaction 30min-60min（Optimum reacting time is 30min）;Wherein, ethanol with the mixed solution of alkali for volumetric concentration is
The ethanol of 90%-98% and concentration for 15wt%-35wt% sodium hydroxide solution (optium concentration is 25wt%) with 1：1 volume ratio
Configuration.
S3:Etherificate is processed:After S2 basification step, monoxone ethanol solution is added in reaction system（Wherein chlorine
The mol ratio of the NaOH in mixed solution of the monoxone in vinyl alcohol solution with ethanol described in S2 with alkali is 2:1-
4:1, optimum mole ratio is 3:1）Etherification reaction is carried out, reaction temperature is 50 DEG C -70 DEG C（Optimum temperature is 70 DEG C）, react 2h-
3h（Optimum reacting time is 2.5h）.
S4：After S3 etherificate process step, vinyl alcohol solution is used（V/V=1:4）PH is adjusted to 7, gauze A is obtained, by yarn
Cloth A is washed 2-3 time for 80% ethanol solution with volumetric concentration（Most preferably 3 times）, the gauze A freeze-drying process after washing is obtained
Obtain sanlose gauze B;
S5：A certain amount of calcium chloride and zinc chloride, wherein chlorination are added in sanlose gauze B obtained in S4
The mass ratio of calcium, zinc chloride and sanlose gauze B is 1:1:2-1:1:4（Optimum quality ratio is 1:1:3 ）, with
Volumetric concentration is medium for 50%-80% ethanol（Most preferably volumetric concentration is 70% ethanol solution）, stir in magnetic force heating stirrer
Mix, at 30 DEG C -70 DEG C（Optimum temperature is 60 DEG C）Lower reaction 2h-4h, is prepared into gauze C；
S6：Gauze C prepared by S5, is 80%-90% ethanol with volumetric concentration（Most preferably volumetric concentration is 85% ethanol）Repeatedly
Washing 2-4 time（Most preferably 3 times）, then freeze-drying obtains the novel antibacterial hemostatic gauze.
It is an advantage of the current invention that：
（1）Obtained novel antibacterial hemostatic gauze has excellent hemostatic function, and its hemostatic mechanism is：
The main component of novel antibacterial hemostatic gauze is carboxyalkylcellulose metal salt, and which is dissolved after contact blood rapidly
Spawn is formed, is sticked in wound well, form physical barriers and oppress blutpunkte；
Carboxyalkylcellulose metal salt gauze contains a certain amount of acidic carboxypolymer, and which can adsorb the Fe in blood3+, form palm fibre
Color spawn, can sealing blood vessels end, form physics hemostasis, moreover it is possible to adsorb, assemble, activating blood platelet, acceleration blood
Solidification；
Containing calcium ion and zinc ion in carboxyalkylcellulose metal salt, wherein calcium ion is clotting factor to promoting blood
Solidification plays a very important role, and zinc ion can also play haemostatic effect.
（2）The main component of novel antibacterial hemostatic gauze be carboxyalkylcellulose metal salt, gauze with wound fluid
In sodium ion swap after, carboxyalkylcellulose metal salt discharges zinc ion, play suppression bacterium increase, protect the surface of a wound
Effect；
（3）The composition of novel antibacterial hemostatic gauze is natural macromolecular material, with good biocompatibility, the spy having no toxic side effect
Point.
Specific embodiment
Embodiment one
A kind of preparation method of novel antibacterial hemostatic gauze, comprises the following steps：
S1:Pretreatment:By medical absorbent cotton gauze soaked in absolute ethyl alcohol 45min；
S2:Basification:Medical absorbent cotton gauze after processing through S1 is immersed in the mixed solution of ethanol and alkali（v/v=1:
1）Quaternization is carried out, with 3:50 mass ratio reacts 60min at a temperature of 25 DEG C;Wherein, the mixed solution of ethanol and alkali
For ethanol that volumetric concentration is 90% and concentration for 15wt% sodium hydroxide solution with 1：1 volume ratio configuration；
S3:Etherificate is processed:After S2 basification step, monoxone ethanol solution is added in reaction system（Wherein monoxone
The mol ratio of the NaOH in mixed solution of the monoxone in ethanol solution with ethanol described in S2 with alkali is 2:1）Carry out
Etherification reaction, reaction temperature are 50 DEG C, react 3h；
S4：After S3 etherificate process step, vinyl alcohol solution is used（V/V=1:4）PH is adjusted to 7, gauze A is obtained, by gauze A
Washed 2 times for 80% ethanol solution with volumetric concentration, the gauze A freeze-drying process after washing obtains sodium carboxymethylcellulose
Salt gauze B;
S5：A certain amount of calcium chloride and zinc chloride, wherein chlorination are added in sanlose gauze B obtained in S4
The mass ratio of calcium, zinc chloride and sanlose gauze B is 1:1:2, with volumetric concentration as 50% ethanol as medium, in
Stir in magnetic force heating stirrer, 4h is reacted at 30 DEG C, be prepared into gauze C；
S6：Gauze C prepared by S5, is 80% ethanol cyclic washing 2 times with volumetric concentration, and then freeze-drying obtains described
Novel antibacterial hemostatic gauze.
Embodiment two
A kind of preparation method of novel antibacterial hemostatic gauze, comprises the following steps：
S1:Pretreatment:By medical absorbent cotton gauze soaked in absolute ethyl alcohol 60min；
S2:Basification:Medical absorbent cotton gauze after processing through S1 is immersed in the mixed solution of ethanol and alkali（v/v=1:
1）Quaternization is carried out, with 3:100 mass ratio reacts 40min at a temperature of 27 DEG C;Wherein, the mixed solution of ethanol and alkali
For ethanol that volumetric concentration is 95% and concentration for 35wt% sodium hydroxide solution with 1：1 volume ratio configuration；
S3:Etherificate is processed:After S2 basification step, monoxone ethanol solution is added in reaction system（Wherein monoxone
The mol ratio of the NaOH in mixed solution of the monoxone in ethanol solution with ethanol described in S2 with alkali is 4:1）Carry out
Etherification reaction, reaction temperature are 60 DEG C, react 2h；
S4：After S3 etherificate process step, vinyl alcohol solution is used（V/V=1:4）PH is adjusted to 7, gauze A is obtained, by gauze A
Washed 2 times for 80% ethanol solution with volumetric concentration, the gauze A freeze-drying process after washing obtains sodium carboxymethylcellulose
Salt gauze B;
S5：A certain amount of calcium chloride and zinc chloride, wherein chlorination are added in sanlose gauze B obtained in S4
The mass ratio of calcium, zinc chloride and sanlose gauze B is 1:1:4, with volumetric concentration as 80% ethanol as medium, in
Stir in magnetic force heating stirrer, 2h is reacted at 70 DEG C, be prepared into gauze C；
S6：Gauze C prepared by S5, is 90% ethanol cyclic washing 4 times with volumetric concentration, and then freeze-drying obtains described
Novel antibacterial hemostatic gauze.
For verifying whether antibacterial hemostatic gauze of the present invention reaches expected invention effect, antibacterial hemostatic gauze of the present invention is entered
Row antibacterial tests and external thrombotest, as a result as shown in table 1 below shown：
1 antibacterial hemostatic gauze antibacterial tests of table and external thrombotest result
As can be seen from Table 1, the antibacterial hemostatic gauze that prepared by the present invention has excellent anti-microbial property and haemostatic effect.
Embodiment three
A kind of preparation method of novel antibacterial hemostatic gauze, comprises the following steps：
S1:Pretreatment:By medical absorbent cotton gauze soaked in absolute ethyl alcohol 30min；
S2:Basification:Medical absorbent cotton gauze after processing through S1 is immersed in the mixed solution of ethanol and alkali（v/v=1:
1）Quaternization is carried out, with 3:70 mass ratio reacts 30min at a temperature of 30 DEG C;Wherein, the mixed solution of ethanol and alkali
For ethanol that volumetric concentration is 98% and concentration for 25wt% sodium hydroxide solution with 1：1 volume ratio configuration；
S3:Etherificate is processed:After S2 basification step, monoxone ethanol solution is added in reaction system（Wherein monoxone
The mol ratio of the NaOH in mixed solution of the monoxone in ethanol solution with ethanol described in S2 with alkali is 3:1）Carry out
Etherification reaction, reaction temperature are 70 DEG C, react 2.5h；
S4：After S3 etherificate process step, vinyl alcohol solution is used（V/V=1:4）PH is adjusted to 7, gauze A is obtained, by gauze A
Washed 3 times for 80% ethanol solution with volumetric concentration, the gauze A freeze-drying process after washing obtains sodium carboxymethylcellulose
Salt gauze B;
S5：A certain amount of calcium chloride and zinc chloride, wherein chlorination are added in sanlose gauze B obtained in S4
The mass ratio of calcium, zinc chloride and sanlose gauze B is 1:1:3, with volumetric concentration as 70% ethanol as medium, in
Stir in magnetic force heating stirrer, 3h is reacted at 60 DEG C, be prepared into gauze C；
S6：Gauze C prepared by S5, is 85% ethanol cyclic washing 3 times with volumetric concentration, and then freeze-drying obtains described
Novel antibacterial hemostatic gauze.
Example IV
A kind of preparation method of novel antibacterial hemostatic gauze, comprises the following steps：
S1:Pretreatment:By medical absorbent cotton gauze soaked in absolute ethyl alcohol 30min；
S2:Basification:Medical absorbent cotton gauze after processing through S1 is immersed in the mixed solution of ethanol and alkali（v/v=1:
1）Quaternization is carried out, with 3:70 mass ratio reacts 30min at a temperature of 30 DEG C;Wherein, the mixed solution of ethanol and alkali
For ethanol that volumetric concentration is 98% and concentration for 25wt% sodium hydroxide solution with 1：1 volume ratio configuration；
S3:Etherificate is processed:After S2 basification step, monoxone ethanol solution is added in reaction system（Wherein monoxone
The mol ratio of the NaOH in mixed solution of the monoxone in ethanol solution with ethanol described in S2 with alkali is 3:1）Carry out
Etherification reaction, reaction temperature are 70 DEG C, react 2.5h；
S4：After S3 etherificate process step, vinyl alcohol solution is used（V/V=1:4）PH is adjusted to 7, gauze A is obtained, by gauze A
Washed 3 times for 80% ethanol solution with volumetric concentration, the gauze A freeze-drying process after washing obtains sodium carboxymethylcellulose
Salt gauze B;
S5：A certain amount of calcium chloride, wherein calcium chloride and carboxymethyl are added in sanlose gauze B obtained in S4
The mass ratio of cellulose sodium salt gauze B is 1:3, with volumetric concentration as 70% ethanol as medium, stir in magnetic force heating stirrer
Mix, 3h is reacted at 60 DEG C, be prepared into gauze C；
S6：Gauze C prepared by S5, is 85% ethanol cyclic washing 3 times with volumetric concentration, and then freeze-drying obtains described
Novel antibacterial hemostatic gauze.
Embodiment five
A kind of preparation method of novel antibacterial hemostatic gauze, comprises the following steps：
S1:Pretreatment:By medical absorbent cotton gauze soaked in absolute ethyl alcohol 30min；
S2:Basification:Medical absorbent cotton gauze after processing through S1 is immersed in the mixed solution of ethanol and alkali（v/v=1:
1）Quaternization is carried out, with 3:70 mass ratio reacts 30min at a temperature of 30 DEG C;Wherein, the mixed solution of ethanol and alkali
For ethanol that volumetric concentration is 98% and concentration for 25wt% sodium hydroxide solution with 1：1 volume ratio configuration；
S3:Etherificate is processed:After S2 basification step, monoxone ethanol solution is added in reaction system（Wherein monoxone
The mol ratio of the NaOH in mixed solution of the monoxone in ethanol solution with ethanol described in S2 with alkali is 3:1）Carry out
Etherification reaction, reaction temperature are 70 DEG C, react 2.5h；
S4：After S3 etherificate process step, vinyl alcohol solution is used（V/V=1:4）PH is adjusted to 7, gauze A is obtained, by gauze A
Washed 3 times for 80% ethanol solution with volumetric concentration, the gauze A freeze-drying process after washing obtains sodium carboxymethylcellulose
Salt gauze B;
S5：A certain amount of zinc chloride, wherein zinc chloride and carboxymethyl are added in sanlose gauze B obtained in S4
The mass ratio of cellulose sodium salt gauze B is 1:3, with volumetric concentration as 70% ethanol as medium, stir in magnetic force heating stirrer
Mix, 3h is reacted at 60 DEG C, be prepared into gauze C；
S6：Gauze C prepared by S5, is 85% ethanol cyclic washing 3 times with volumetric concentration, and then freeze-drying obtains described
Novel antibacterial hemostatic gauze.
Embodiment six（Blank group）
A kind of preparation method of novel antibacterial hemostatic gauze, comprises the following steps：
S1:Pretreatment:By medical absorbent cotton gauze soaked in absolute ethyl alcohol 30min；
S2:Basification:Medical absorbent cotton gauze after processing through S1 is immersed in the mixed solution of ethanol and alkali（v/v=1:
1）Quaternization is carried out, with 3:70 mass ratio reacts 30min at a temperature of 30 DEG C;Wherein, the mixed solution of ethanol and alkali
For ethanol that volumetric concentration is 98% and concentration for 25wt% sodium hydroxide solution with 1：1 volume ratio configuration；
S3:Etherificate is processed:After S2 basification step, monoxone ethanol solution is added in reaction system（Wherein monoxone
The mol ratio of the NaOH in mixed solution of the monoxone in ethanol solution with ethanol described in S2 with alkali is 3:1）Carry out
Etherification reaction, reaction temperature are 70 DEG C, react 2.5h；
S4：After S3 etherificate process step, vinyl alcohol solution is used（V/V=1:4）PH is adjusted to 7, gauze A is obtained, by gauze A
Washed 3 times for 80% ethanol solution with volumetric concentration, the gauze A freeze-drying process after washing obtains sodium carboxymethylcellulose
Salt gauze B;
S5：By obtained in S4 sanlose gauze B add volumetric concentration be 70% ethanol in, in magnetic force heating stirring
Stir in device, 3h is reacted at 60 DEG C, be prepared into gauze C；
S6：Gauze C prepared by S5, is 85% ethanol cyclic washing 3 times with volumetric concentration, and then freeze-drying obtains described
Novel antibacterial hemostatic gauze.
For verifying whether antibacterial hemostatic gauze of the present invention reaches expected invention effect, embodiment three to embodiment six is obtained
To antibacterial hemostatic gauze carry out external thrombotest and antibacterial experiment, as a result as shown in the table：
The external thrombotest of 2 antibacterial hemostatic gauze of table
From table 2 it can be seen that the antibacterial hemostatic gauze prepared by the present invention has excellent anthemorrhagic performance.In preparation process
In, calcium chloride and zinc chloride are added in sanlose gauze, obtained antibacterial hemostatic gauze can be significantly improved
Anthemorrhagic performance, also, three have synergy, be used in conjunction with haemostatic effect more notable.
3 antibacterial hemostatic gauze antibacterial tests of table
From table 3 it can be seen that antibacterial hemostatic gauze prepared by the present invention has excellent anti-microbial property.By chlorine in preparation process
Change zinc to add in sanlose gauze, the haemostatic effect of prepared hemostatic gauze can be improved, is simultaneously introduced zinc chloride
And calcium chloride, due to the synergy of three, antibacterial effect is more preferably.
It should be pointed out that specific embodiment is the more representational example of the present invention, it is clear that the skill of the present invention
Art scheme is not limited to above-described embodiment, can also have many variations.One of ordinary skill in the art, clearly public with present invention institute
What what written description that open or according to file was undoubted obtained, all it is considered as this patent scope of the claimed.
Claims (8)
1. a kind of novel antibacterial hemostatic gauze, it is characterised in that the novel antibacterial hemostatic gauze main component is that carboxymethyl is fine
The plain slaine of dimension, the carboxyalkylcellulose metal salt is sodium carboxymethylcellulose, calcium carboxymethylcellulose and carboxymethyl cellulose
Plain zinc.
2. a kind of preparation method of novel antibacterial hemostatic gauze according to claim 1, it is characterised in that the preparation side
Method is to carry out according to the following steps：
S1：Pretreatment:By medical absorbent cotton gauze soaked in absolute ethyl alcohol 30min-60min;
S2：Basification:Medical absorbent cotton gauze after processing through S1 is immersed in the mixed solution of ethanol and alkali and carries out alkali
Change reaction, with 3:100-3:50 mass ratio reacts 30min-60min at a temperature of 25 DEG C -30 DEG C;
S3：Etherificate is processed:After S2 basification step, in reaction system, monoxone ethanol solution is added, carry out being etherified instead
Should；
S4：After S3 etherificate process step, PH is adjusted to 7 with vinyl alcohol solution, gauze A is obtained, will be dense with volume for gauze A
Spend for the washing of 80% ethanol solution repeatedly, the gauze A freeze-drying process after washing obtains sanlose gauze
B;
S5：A certain amount of calcium chloride and zinc chloride are added in sanlose gauze B obtained in S4, with ethanol as being situated between
Matter, stirs in magnetic force heating stirrer, reacts 2h-4h, be prepared into gauze C at 30 DEG C -70 DEG C；
S6：Gauze C prepared by S5, then freeze-drying obtains novel antibacterial hemostasis with ethanol cyclic washing repeatedly
Gauze.
3. the preparation method of a kind of novel antibacterial hemostatic gauze according to claim 2, it is characterised in that in the S2
Ethanol is the ethanol that volumetric concentration is 90%-98% and the sodium hydroxide solution that concentration is 15wt%-35wt% with the mixed solution of alkali
With 1：1 volume ratio configuration.
4. the preparation method of a kind of novel antibacterial hemostatic gauze according to claim 3, it is characterised in that described in wherein S3
Monoxone ethanol solution in mixed solution of the monoxone with ethanol described in S2 with alkali in the mol ratio of NaOH be
2:1-4:1.
5. the preparation method of a kind of novel antibacterial hemostatic gauze according to claim 2, it is characterised in that described in wherein S3
Etherification reaction temperature be 50 DEG C -70 DEG C, the etherification reaction time be 2h-3h.
6. the preparation method of a kind of novel antibacterial hemostatic gauze according to claim 2, it is characterised in that described in wherein S4
Washing times be 2-3 time.
7. the preparation method of a kind of novel antibacterial hemostatic gauze according to claim 2, it is characterised in that described in wherein S5
The mass ratio of calcium chloride, zinc chloride and sanlose gauze B is 1:1:2-1:1:4, the ethanol body described in wherein S5
Product concentration is 50%-80%.
8. a kind of preparation method of novel antibacterial hemostatic gauze according to claim 2, it is characterised in that institute in wherein S6
It is 2-4 time volumes of aqueous ethanol concentration to be stated for the washing times described in 80%-90%, S6.
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Cited By (5)
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| CN107254732A (en) * | 2017-05-31 | 2017-10-17 | 太仓东能环保设备有限公司 | A kind of high water absorption medical absorbent cotton gauze and preparation method thereof |
| CN108102030A (en) * | 2018-01-09 | 2018-06-01 | 南通华利康医疗器械有限公司 | A kind of high-molecular copolymer material with anastalsis and preparation method thereof |
| CN108653718A (en) * | 2018-05-31 | 2018-10-16 | 广州润虹医药科技股份有限公司 | A kind of absorbable promoting healing hemostatic composition and dressing |
| CN109125794A (en) * | 2018-09-07 | 2019-01-04 | 广州迈普再生医学科技股份有限公司 | A kind of degradable high water-absorbing styptic powder and its preparation method and application |
| CN112569400A (en) * | 2020-11-13 | 2021-03-30 | 东华大学 | Janus hemostatic dressing and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107254732A (en) * | 2017-05-31 | 2017-10-17 | 太仓东能环保设备有限公司 | A kind of high water absorption medical absorbent cotton gauze and preparation method thereof |
| CN108102030A (en) * | 2018-01-09 | 2018-06-01 | 南通华利康医疗器械有限公司 | A kind of high-molecular copolymer material with anastalsis and preparation method thereof |
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| CN109125794A (en) * | 2018-09-07 | 2019-01-04 | 广州迈普再生医学科技股份有限公司 | A kind of degradable high water-absorbing styptic powder and its preparation method and application |
| CN109125794B (en) * | 2018-09-07 | 2021-08-31 | 广州迈普再生医学科技股份有限公司 | Degradable high-water-absorptivity hemostatic powder and preparation method and application thereof |
| CN112569400A (en) * | 2020-11-13 | 2021-03-30 | 东华大学 | Janus hemostatic dressing and preparation method thereof |
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Application publication date: 20170308 |