CN106470991B - 在中枢神经系统障碍治疗中的2,4-噻唑烷二酮衍生物 - Google Patents

在中枢神经系统障碍治疗中的2,4-噻唑烷二酮衍生物 Download PDF

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CN106470991B
CN106470991B CN201580018404.6A CN201580018404A CN106470991B CN 106470991 B CN106470991 B CN 106470991B CN 201580018404 A CN201580018404 A CN 201580018404A CN 106470991 B CN106470991 B CN 106470991B
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disease
nervous system
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CN106470991A (zh
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A·M·加西亚克拉佐
D·J·A·埃克兰德
M·P·皮兹库塔拉朗扎
M·马蒂内尔皮德蒙特
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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CN201580018404.6A 2014-04-02 2015-04-01 在中枢神经系统障碍治疗中的2,4-噻唑烷二酮衍生物 Active CN106470991B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14382130.4 2014-04-02
EP14382130 2014-04-02
PCT/EP2015/057224 WO2015150476A1 (en) 2014-04-02 2015-04-01 2,4-thiazolidinedione derivatives in the treatment of central nervous system disorders

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US8722710B2 (en) 2007-09-26 2014-05-13 Deuterx, Llc Deuterium-enriched pioglitazone
US20130158077A1 (en) 2011-12-19 2013-06-20 Ares Trading S.A. Pharmaceutical compositions
US8969581B2 (en) 2013-03-14 2015-03-03 Deuterx, Llc 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same
WO2015109037A1 (en) 2014-01-15 2015-07-23 Deuterx, Llc Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone
ES2678046T3 (es) * 2014-04-02 2018-08-08 Minoryx Therapeutics S.L. Derivados de 2,4-tiazolidindiona en el tratamiento de trastornos del sistema nervioso central
LT3548026T (lt) * 2016-12-01 2021-05-25 Minoryx Therapeutics S.L. 5-[[4-[2-[5-(1-hidroksietil)piridin-2-il]etoksi]fenil]metil]-1,3-tiazolidin-2,4-dionas nealkoholinio kepenų suriebėjimo gydymui
EP3559010B1 (en) * 2016-12-23 2022-06-08 Minoryx Therapeutics S.L. Process for preparing 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione and salts thereof
PL3801515T3 (pl) 2018-06-06 2025-07-14 Minoryx Therapeutics S.L. 5-[[4-[2-[5-(1-hydroksyetylo)pirydyn-2-ylo]etoksy]fenylo]metylo]-1,3-tiazolidyno-2,4-dion i jego sole do zastosowania w leczeniu chorób mitochondrialnych
WO2019234689A1 (en) * 2018-06-06 2019-12-12 Minoryx Therapeutics S.L. Method of administering a therapeutically effective amount of 5-[[4-[2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
US20210228558A1 (en) 2018-06-06 2021-07-29 Minoryx Therapeutics S.L. Use of 5-[[4-[2-[5-acetylpyridin-2-yl]ethoxy]benzyl]-1,3-thiazolidine-2,4-dione and its salts
KR20230035522A (ko) 2020-04-30 2023-03-14 미노릭스 테라퓨틱스 에스.엘. 폐 염증 및 간질성 폐 질병을 치료하기 위한 레리글리타존
US11767317B1 (en) 2020-06-30 2023-09-26 Poxel Sa Methods of synthesizing enantiopure deuterium-enriched pioglitazone
US11319313B2 (en) 2020-06-30 2022-05-03 Poxel Sa Crystalline forms of deuterium-enriched pioglitazone
WO2024141951A1 (en) 2022-12-28 2024-07-04 Minoryx Therapeutics S.L. Optimized dosing of leriglitazone
AU2024268104A1 (en) 2023-05-09 2025-11-27 Minoryx Therapeutics S.L. Polymorphic forms and formulations of leriglitazone

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WO1993022445A1 (en) * 1992-05-05 1993-11-11 The Upjohn Company A process for producing pioglitazone metabolite
WO2013040419A1 (en) * 2011-09-14 2013-03-21 The Trustees Of Columbia University In The City Of New York Compositions and methods for treating hyperprolinemia-associated mental disorders
US20140275180A1 (en) * 2013-03-14 2014-09-18 Deuterx, Llc 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same

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ES2678046T3 (es) * 2014-04-02 2018-08-08 Minoryx Therapeutics S.L. Derivados de 2,4-tiazolidindiona en el tratamiento de trastornos del sistema nervioso central

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WO1992018501A1 (en) * 1991-04-11 1992-10-29 The Upjohn Company Thiazolidinedione derivatives, production and use thereof
WO1993022445A1 (en) * 1992-05-05 1993-11-11 The Upjohn Company A process for producing pioglitazone metabolite
WO2013040419A1 (en) * 2011-09-14 2013-03-21 The Trustees Of Columbia University In The City Of New York Compositions and methods for treating hyperprolinemia-associated mental disorders
US20140275180A1 (en) * 2013-03-14 2014-09-18 Deuterx, Llc 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same

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CN106470991A (zh) 2017-03-01
EA201691997A1 (ru) 2017-02-28
MX2016012687A (es) 2017-04-27
JP2017511339A (ja) 2017-04-20
CY1124088T1 (el) 2022-05-27
EA035866B1 (ru) 2020-08-21
KR20160145639A (ko) 2016-12-20
ES2872335T3 (es) 2021-11-02
ZA201607286B (en) 2021-07-28
EP3388064A1 (en) 2018-10-17
EA202091120A3 (ru) 2020-12-30
LT3388064T (lt) 2021-05-25
US20180133202A1 (en) 2018-05-17
US9782395B2 (en) 2017-10-10
DK3125888T3 (en) 2018-06-25
AU2015239112A1 (en) 2016-11-10
PT3125888T (pt) 2018-07-20
EP3125888A1 (en) 2017-02-08
PL3125888T3 (pl) 2018-09-28
ES2678046T3 (es) 2018-08-08
EA202091120A2 (ru) 2020-08-31
CA2943373A1 (en) 2015-10-08
NZ725492A (en) 2023-06-30
HUE055351T2 (hu) 2022-05-28
IL248037A0 (en) 2016-11-30
SG11201608218QA (en) 2016-10-28
AU2015239112C1 (en) 2020-08-20
US10179126B2 (en) 2019-01-15
US20190255032A1 (en) 2019-08-22
CA2943373C (en) 2023-01-10
PT3388064T (pt) 2021-05-14
EP3125888B1 (en) 2018-05-23
SI3388064T1 (sl) 2021-08-31
BR112016022974A2 (pt) 2017-12-26
CY1120454T1 (el) 2019-07-10
AU2015239112B2 (en) 2020-05-07
MX373234B (es) 2020-05-08
PL3388064T3 (pl) 2021-07-19
JP2020117539A (ja) 2020-08-06
US20160235729A1 (en) 2016-08-18
SI3125888T1 (en) 2018-08-31
KR102418167B1 (ko) 2022-07-08
WO2015150476A1 (en) 2015-10-08
HUE039555T2 (hu) 2019-01-28
HRP20180983T1 (hr) 2018-08-10
CL2016002508A1 (es) 2017-04-21
JP6745726B2 (ja) 2020-08-26
HRP20210518T1 (hr) 2021-05-14
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EP3388064B1 (en) 2021-03-10
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