CN106466397A - Siraidia grosvenorii composite total saponin - Google Patents
Siraidia grosvenorii composite total saponin Download PDFInfo
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- CN106466397A CN106466397A CN201510497543.3A CN201510497543A CN106466397A CN 106466397 A CN106466397 A CN 106466397A CN 201510497543 A CN201510497543 A CN 201510497543A CN 106466397 A CN106466397 A CN 106466397A
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- composite total
- siraidia
- grosvenorii
- fructus momordicae
- panacis japonici
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Abstract
The present invention is the composite total saponins extracting in three kinds of natural plants, and the weight ratio of its raw material is：Fructus Momordicae 50-70, Rhizoma Panacis Japonici 20-30, Dioscorea zingiberensis 10-45.By Fructus Momordicae, Rhizoma Panacis Japonici, three kinds of plant cleaning, drying of Dioscorea zingiberensis, pulverize as fine powder, in proportion formula mixing, extracted with CO2 supercritical technology, that is, make the Siraidia grosvenorii composite total saponin of the present invention.It has treatment dental fluorosis, tetracycline pigmentation teeth and various chemical tooth injury activity, also has preventing and treating odontoseisiss, periodontitis, the effect of toothache.
Description
Technical field：
The present invention is planted with the compound recipe for the treatment of dental fluorosis, tetracycline pigmentation teeth, chemical tooth injury, odontoseisiss, periodontitis, toothache
It is relevant that thing extracts Total saponin.
Background technology：
There is no the compound recipe Saponin that will be extracted after Fructus Momordicae, Rhizoma Panacis Japonici, Dioscorea zingiberensis formula in existing plant sapogenin glycoside, more do not have
This Siraidia grosvenorii composite total saponin is used for treating dental fluorosis, tetracycline pigmentation teeth, chemical tooth injury, odontoseisiss, periodontitis, tooth
The precedents such as pain.
Content of the invention：
It is an object of the invention to provide one kind employs unique prescription, carry from Fructus Momordicae, Rhizoma Panacis Japonici, three kinds of plants of Dioscorea zingiberensis
The composite total saponins taking out.This Saponin have treatment dental fluorosis, tetracycline pigmentation teeth, chemical tooth injury, odontoseisiss, periodontitis,
The multiple efficacies such as toothache.
The present invention is realized in：
The present invention be a kind of treat dental fluorosis, tetracycline pigmentation teeth, chemical tooth injury, odontoseisiss, periodontitis, toothache answer
Square plant extract Total saponin.Its raw material is made up of Fructus Momordicae, Rhizoma Panacis Japonici, three kinds of plants of Dioscorea zingiberensis.
In prescription of the present invention, the weight ratio of the former section of three kinds of plants is as follows：
Fructus Momordicae 50-70
Rhizoma Panacis Japonici 20-30
Dioscorea zingiberensis 10-45
Three of the above plant seed is washed, 50 DEG C of aeration-dryings, pulverize as 30-50 mesh fine powder, then in proportion
To mix after three kinds of fine powder formula, insert in supercritical extraction device, extracted using CO2 supercritical extraction technology.
Control the pressure extracting in kettle under conditions of (26-42) Ma, temperature deposit 45-55 DEG C, after extracting 3h, by supercritical fluid CO 2
Extract enters separator, and, at 36-46 DEG C, pressure, under conditions of (12-18) MPa, is isolated to control temperature in separator
Fructus Momordicae, Rhizoma Panacis Japonici, Dioscorea zingiberensis composite total saponins, that is, make the Siraidia grosvenorii composite total saponin of the present invention.
The present invention with Fructus Momordicae as primary raw material, Research Literature data show mogrosides to pathogenic staphylococcus aureuses,
Staphylococcus albus, catalin diplococcus have stronger inhibitory activity.In mogrosides, mogroside IV and Fructus Momordicae hardship glycoside A has
Prevent and treat anti-treating dental ulcer, antiinflammatory, the activity of hemostasis.
With Rhizoma Panacis Japonici for secondary raw material, it is multiple that Research Literature data shows that chickusetsusaponin has antiinflammatory, antiviral etc. to the present invention
Activity；Wherein the activity of oral disease is had：Anti- dentin hypersensitiveness, has restoration and protection to act on, also anti-teeth inflammation is stopped to enamel
Blood analgesic activities.
With Dioscorea zingiberensis for secondary raw material, the diosgenin in Dioscorea zingiberensis has the various active such as hemostasis, antiinflammatory to the present invention, is to manufacture doctor
The raw material of medicine.Diosgenin also has and can produce a large amount of foams with water mixing shaking, has similar saponiform surface activity, can take out
Take detergent, emulsifying agent, foaming agent etc..Rhizoma Dioscoreae Hypoglaucae Saponin (C in Dioscorea zingiberensis51H82O23) there is osteoblast in antagonism dental gram
The activity adjusted the activity died and eliminate tooth sleeve matter coloring because of harmful chemical impact.
Fructus Momordicae, Rhizoma Panacis Japonici, Dioscorea zingiberensis are pressed certain formula proportion cooperation, and are adopted CO2 supercritical extraction skill by the present invention
Art extracts its Saponin, has the synergism strengthening three kinds of raw material activity.
We have carried out human experimentation to multiple dental fluorosis patients, have formulated clinical prerun scheme, allow qualified fluorine spot
3 times a day for tooth patient, uses every time Siraidia grosvenorii composite total saponin to brush teeth 1-3 minute, test 90 days altogether, by 100 fluorine spots
Tooth patient's Ureteral Calculus, show that the made Siraidia grosvenorii composite total saponin therapeutic effect of inventive formulation is good, wherein cure 85,
Notable 9, effectively：3, total effective rate 94%, total effective rate 97%.
Equally human experimentation is carried out to tetracycline pigmentation teeth patient, give qualified patient 3 times a day to use Fructus Momordicae every time
Composite total saponins are brushed teeth 1-3 minute, test 50 days altogether, by testing to 80 tetracycline pigmentation teeth patients, wherein cure 63
Example, notable 12, effective 4, total effective rate：93.75%, total effective rate 98.75%.
Human trial is carried out to chemical tooth injury patient, 3 times a day to allow eligible person, use Fructus Momordicae to be combined every time
Total saponin is brushed teeth 1-3 minute, tests 40 days altogether, by carrying out experimental observation to 120 chemical tooth injury patients, shows this
The made Siraidia grosvenorii composite total saponin therapeutic effect of invention formula is good, wherein, cures 106, notable 7, effective 3,
Total effective rate 94.2%, total effective rate 96.7%.
Human trial is carried out to odontoseisiss patient, 3 times a day, every time using Siraidia grosvenorii composite total saponin to allow eligible person
Brush teeth 1-3 minute, test 30 days altogether, by 100 odontoseisiss Ureteral Calculus, showing the made Fructus Momordicae of inventive formulation
Composite total saponins therapeutic effect is good, wherein cures 85, notable 9, effective 3, total effective rate 94%, always effectively
Rate 97%.
Human trial is carried out to patients with periodontitis, 3 times a day, every time using Siraidia grosvenorii composite total saponin to allow eligible person
Brush teeth 1-3 minute, test 90 days altogether, by experimental observation is carried out to 60 patients with periodontitis, show that inventive formulation is made
Siraidia grosvenorii composite total saponin therapeutic effect good, wherein, cure 51, notable 4, effective 3, total effective rate 91.7
%, total effective rate 96.7%.
Human trial is carried out to patient with toothache, 2 times a day to allow eligible person, use Siraidia grosvenorii composite total saponin brush every time
Tooth 1-3 minute, tests 7 days altogether, by testing to 110 patient with toothache persons, wherein significantly effective 101, typically
Effective 9, total effective rate 91.82%, total effective rate 100%.
This Siraidia grosvenorii composite total saponin is consistent to patient's curative effect of all ages and classes, the different course of disease, respond well, embodies,
Curative effect determines, does not find obvious adverse reaction in experiment.
In sum understand, the present invention to treatment dental fluorosis, tetracycline pigmentation teeth, chemical tooth injury, odontoseisiss, periodontitis,
Toothache etc. has multiple efficacies.
Specific embodiment：
Formula such as following table：
| 1 | 2 | 3 | 4 | 5 | |
| Fructus Momordicae | 50 | 55 | 62 | 65 | 68 |
| Semen Euphorbiae | 23 | 26 | 25 | 28 | 30 |
| Dioscorea zingiberensis | 11 | 20 | 28 | 36 | 42 |
Preparation technology：
Fructus Momordicae, Rhizoma Panacis Japonici, three kinds of plant seeds of Dioscorea zingiberensis are washed, 50 DEG C of aeration-dryings, pulverize thin for 30-50 mesh
Powder.
After qualified Fructus Momordicae, Rhizoma Panacis Japonici, Dioscorea zingiberensis fine powder are prepared in proportion, load and extract in kettle.
After charged, with high pressure metering pump, liquid CO 2 boosting warp let-off preheater is preheated so as to become SCF-CO 2
Body, then from extracting the injection of kettle bottom, is extracted by Fructus Momordicae, Rhizoma Panacis Japonici, Dioscorea zingiberensis charging layer in kettle.Control and extract kettle
Interior pressure, after extracting 3h, by the kettle overhead-valve extracting kettle top, is controlled in (26-42) MPa, temperature under conditions of 45-55 DEG C
Uniform and stable processed enters in separator.
Supercritical CO 2 filter body extract enter separator after, because of pressure drop, density diminishes, Fructus Momordicae, Rhizoma Panacis Japonici,
Dioscorea zingiberensis composite total saponins therefore change and separate out：, at 36-46 DEG C, pressure is in the bar of (12-18) MPa to control temperature in separator
Under part, Fructus Momordicae, Rhizoma Panacis Japonici, Dioscorea zingiberensis are combined Saponin and can preferably separate out in separator, just can obtain arhat from separator bottom
Fruit composite total saponins product, that is, make the Siraidia grosvenorii composite total saponin of the present invention.
Claims (2)
1. a kind of composite total saponins extracting from natural plants Fructus Momordicae, Rhizoma Panacis Japonici, three kinds of plants of Dioscorea zingiberensis, its formula proportion is sieve
Chinese fruit 50-70, Rhizoma Panacis Japonici 20-30, Dioscorea zingiberensis 10-45.
2. the composite total saponins described in a kind of claim 1, is characterized in that extracting using CO2 supercritical technology, its extractive technique parameter
It is：Extracting the pressure in axe is (26-42) MPa, and temperature is 45-55 DEG C, and the time is 3h；Pressure in separator is (12
- 18) MPa, temperature is 36-46 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510497543.3A CN106466397A (en) | 2015-08-14 | 2015-08-14 | Siraidia grosvenorii composite total saponin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510497543.3A CN106466397A (en) | 2015-08-14 | 2015-08-14 | Siraidia grosvenorii composite total saponin |
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| CN106466397A true CN106466397A (en) | 2017-03-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510497543.3A Pending CN106466397A (en) | 2015-08-14 | 2015-08-14 | Siraidia grosvenorii composite total saponin |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1378278A (en) * | 1972-03-31 | 1974-12-27 | Pacific Chem Ind Co | Total saponin extracts from panax ginseng c a meyer and process for the production thereof |
| CN102793824A (en) * | 2011-05-23 | 2012-11-28 | 常昊 | Siraidia grosvenorii composite total saponin |
-
2015
- 2015-08-14 CN CN201510497543.3A patent/CN106466397A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1378278A (en) * | 1972-03-31 | 1974-12-27 | Pacific Chem Ind Co | Total saponin extracts from panax ginseng c a meyer and process for the production thereof |
| CN102793824A (en) * | 2011-05-23 | 2012-11-28 | 常昊 | Siraidia grosvenorii composite total saponin |
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Application publication date: 20170301 |
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