CN102793824A - Siraidia grosvenorii composite total saponin - Google Patents
Siraidia grosvenorii composite total saponin Download PDFInfo
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- CN102793824A CN102793824A CN2011101332208A CN201110133220A CN102793824A CN 102793824 A CN102793824 A CN 102793824A CN 2011101332208 A CN2011101332208 A CN 2011101332208A CN 201110133220 A CN201110133220 A CN 201110133220A CN 102793824 A CN102793824 A CN 102793824A
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- siraidia
- grosvenorii
- composite total
- fructus momordicae
- total saponin
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Abstract
The invention relates to a composite total saponin extracted from three natural plants. The weight ratio of raw materials is 50-70 of siraidia grosvenorii, 20-30 of panax japonicus and 10-45 of dioscorea zingiberensis. The siraidia grosvenorii composite total saponin is prepared by washing the three plants of siraidia grosvenorii, panax japonicus and dioscorea zingiberensis, drying and smashing into fine powder, mixing according to a ratio formula, and extracting with a CO2 supercritical technology. The siraidia grosvenorii composite total saponin has the activities of treating dental fluorosis, tetracycline pigmentation teeth and chemical tooth damages, and has the effects of preventing odontoseisis, periodontitis and toothache.
Description
Technical field:
It is relevant that the present invention and the compound plant of treatment dental fluorosis, tetracycline pigmentation teeth, chemical tooth injury, odontoseisis, periodontitis, toothache extract total Saponin.
Background technology:
Still the compound recipe Saponin that is extracted behind no-trump Fructus Momordicae, Rhizoma Panacis Japonici, the HUANGJIANG prescription in the existing plant sapogenin glycoside more is not used to treat precedents such as dental fluorosis, tetracycline pigmentation teeth, chemical tooth injury, odontoseisis, periodontitis, toothache with this Fructus Momordicae composite total saponins.
Summary of the invention:
The purpose of this invention is to provide a kind of unique prescription that used, the composite total saponins that from Fructus Momordicae, Rhizoma Panacis Japonici, HUANGJIANG three kind of plant, extracts.This Saponin has multiple efficacies such as treatment dental fluorosis, tetracycline pigmentation teeth, chemical tooth injury, odontoseisis, periodontitis, toothache.
The present invention is achieved in that
The present invention is that a kind of compound plant of treating dental fluorosis, tetracycline pigmentation teeth, chemical tooth injury, odontoseisis, periodontitis, toothache extracts total Saponin.Its raw material is made up of Fructus Momordicae, Rhizoma Panacis Japonici, HUANGJIANG three kind of plant.
The weight ratio of the former section of three kind of plant is following in the prescription of the present invention:
Fructus Momordicae 50-70
Rhizoma Panacis Japonici 20-30
HUANGJIANG 10-45
Above three kind of plant seeds are washed, and 50 ℃ of aeration-dryings are pulverized and are 30-50 order fine powder, in proportion with mixing behind three kinds of fine powder prescriptions, insert in the supercritical extraction device then, adopt CO2 supercritical extraction technology to extract.Control is extracted the interior pressure of still and is deposited in (26-42) Ma, temperature under 45-55 ℃ the condition; After extracting 3h; Supercritical CO 2 fluid extraction thing is got into separator, and temperature is at 36-46 ℃ in the control separator, and pressure is under the condition of (12-18) MPa; Isolate Fructus Momordicae, Rhizoma Panacis Japonici, HUANGJIANG composite total saponins, promptly process Fructus Momordicae composite total saponins of the present invention.
The present invention is primary raw material with the Fructus Momordicae, and the research documents and materials show that the Fructus Momordicae Saponin has stronger inhibition active to the staphylococcus aureus of causing a disease, Staphylococcus albus, catalin diplococcus.The bitter glycoside A of mogroside IV and Fructus Momordicae has the anti-treating dental ulcer of control, antiinflammatory, hemostatic activity in the Fructus Momordicae Saponin.
The present invention is less important raw material with Rhizoma Panacis Japonici, and the research documents and materials show that chickusetsusaponin has various active such as antiinflammatory, antiviral; Wherein the activity to oral disease has: anti-dentin hypersensitiveness, enamel there is the restoration and protection effect, and also have anti-teeth inflammation hemostatic analgesia active.
The present invention is less important raw material with HUANGJIANG, and the diosgenin in the HUANGJIANG has various active such as hemostasis, antiinflammatory, is the raw material of making medicine.Diosgenin also has with water mixing jolting can produce significant foam, and similar saponiform surface activity is arranged, and can extract detergent, emulsifying agent, foaming agent etc.Rhizoma Dioscoreae Hypoglaucae Saponin (C in the HUANGJIANG
51H
82O
23) have osteoblast in the antagonism dental gram and transfers die active because of the harmful chemical influence and eliminate the tooth painted activity of matter of tucking inside the sleeve.
The present invention cooperates Fructus Momordicae, Rhizoma Panacis Japonici, HUANGJIANG by certain formula proportion, and adopts CO2 supercritical extraction technology to extract its Saponin, and three kinds of active synergism of raw material of reinforcement are arranged.
We have carried out human experimentation to multiple dental fluorosis patient, have formulated clinical prerun scheme, let qualified dental fluorosis patient every day 3 times; Each Fructus Momordicae composite total saponins that uses was brushed teeth 1-3 minute, tested altogether 90 days, observed through 100 routine dental fluorosis patient treatments; Show that the Fructus Momordicae composite total saponins therapeutic effect that the present invention fills a prescription made is good, wherein cure 85 examples, remarkable 9 examples; Effectively: 3 examples, total obvious effective rate 94%, total effective rate 97%.
Equally the tetracycline pigmentation teeth patient is carried out human experimentation, give qualified patient every day 3 each Fructus Momordicae composite total saponins that use and brushed teeth 1-3 minute, tested altogether 50 days; Through 80 routine tetracycline pigmentation teeth patients are made an experiment; Wherein cure 63 examples, remarkable 12 examples, effective 4 examples; Total obvious effective rate: 93.75%, total effective rate 98.75%.
The chemical tooth injury patient is carried out human trial, let eligible person every day 3 times, use the Fructus Momordicae composite total saponins to brush teeth at every turn 1-3 minute; Tested altogether 40 days, and, showed that the Fructus Momordicae composite total saponins therapeutic effect that the present invention fills a prescription made was good through observation that 120 routine chemical tooth injury patients are made an experiment; Wherein, cure 106 examples, remarkable 7 examples; Effective 3 examples, total obvious effective rate 94.2%, total effective rate %.7%.
The odontoseisis patient is carried out human trial, let eligible person every day 3 times, use the Fructus Momordicae composite total saponins to brush teeth at every turn 1-3 minute; Tested altogether 30 days, through to 100 routine odontoseisiss treatment observe, show that the Fructus Momordicae composite total saponins therapeutic effect that the present invention fills a prescription made is good; Wherein cure 85 examples, remarkable 9 examples, effective 3 examples; Total obvious effective rate 94%, total effective rate 97%.
Patients with periodontitis is carried out human trial, let eligible person every day 3 times, use the Fructus Momordicae composite total saponins to brush teeth at every turn 1-3 minute; Tested altogether 90 days, and, showed that the Fructus Momordicae composite total saponins therapeutic effect that the present invention fills a prescription made was good through observation that 60 routine patients with periodontitis are made an experiment; Wherein, cure 51 examples, remarkable 4 examples; Effective 3 examples, total obvious effective rate 91.7%, total effective rate 96.7%.
The toothache patient is carried out human trial, let eligible person every day 2 times, use the Fructus Momordicae composite total saponins to brush teeth at every turn 1-3 minute; Tested altogether 7 days; Through 110 example toothache patient persons being made an experiment wherein remarkable effective 101 examples, general effective 9 examples; Total obvious effective rate 91.82%, total effective rate 100%.
This Fructus Momordicae composite total saponins is consistent, respond well to patient's curative effect of all ages and classes, the different courses of disease, specializes, and curative effect is confirmed, do not found obvious adverse reaction in the experiment.
Can know that in sum the present invention has multiple efficacies to treatment dental fluorosis, tetracycline pigmentation teeth, chemical tooth injury, odontoseisis, periodontitis, toothache etc.
The specific embodiment:
Fill a prescription like following table:
1 | 2 | 3 | 4 | 5 | |
Fructus Momordicae | 50 | 55 | 62 | 65 | 68 |
Semen Euphorbiae | 23 | 26 | 25 | 28 | 30 |
HUANGJIANG | 11 | 20 | 28 | 36 | 42 |
Preparation technology:
Fructus Momordicae, Rhizoma Panacis Japonici, HUANGJIANG three kind of plant seeds are washed, and 50 ℃ of aeration-dryings are pulverized and are 30-50 order fine powder.
After qualified Fructus Momordicae, Rhizoma Panacis Japonici, HUANGJIANG fine powder prepared in proportion, pack into and extract in the still.
Behind the charged, with the liquid CO 2 warp let-off preheater preheating of boosting, make it become the supercritical CO 2 fluid, inject from extracting the still bottom then, extract through Fructus Momordicae, Rhizoma Panacis Japonici, HUANGJIANG charging layer in the still with the high pressure metering pump.Control extract pressure in the still in (26-42) MPa, temperature under 45-55 ℃ condition, extract 3h after, by the still overhead-valve that extracts still top, the control uniform and stable gets in the separator.
Supercritical CO 2 is filtered behind the body extract entering separator; Because of pressure descends, density diminishes, and therefore Fructus Momordicae, Rhizoma Panacis Japonici, HUANGJIANG composite total saponins change and separate out: temperature is at 36-46 ℃ in the control separator; Pressure is under the condition of (12-18) MPa; Fructus Momordicae, Rhizoma Panacis Japonici, the compound Saponin of HUANGJIANG can better be separated out in separator, just can obtain Fructus Momordicae composite total saponins product from the separator bottom, promptly process Fructus Momordicae composite total saponins of the present invention.
Claims (2)
1. composite total saponins that from natural plants Fructus Momordicae, Rhizoma Panacis Japonici, HUANGJIANG three kind of plant, extracts, its formula proportion is Fructus Momordicae 50-70, Rhizoma Panacis Japonici 20-30, HUANGJIANG 10-45..
2. the described composite total saponins of claim 1 is characterized in that adopting the CO2 supercritical technology to extract, and its extractive technique parameter is: the pressure that extracts in the axe is (26-42) MPa, and temperature is 45-55 ℃, and the time is 3h; Pressure in the separator is (12-18) MPa, and temperature is 36-46 ℃.
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CN2011101332208A CN102793824A (en) | 2011-05-23 | 2011-05-23 | Siraidia grosvenorii composite total saponin |
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CN2011101332208A CN102793824A (en) | 2011-05-23 | 2011-05-23 | Siraidia grosvenorii composite total saponin |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104137979A (en) * | 2014-07-29 | 2014-11-12 | 桂林实力科技有限公司 | Fructus momordicae aspartame and preparation method thereof |
CN106466397A (en) * | 2015-08-14 | 2017-03-01 | 常昊 | Siraidia grosvenorii composite total saponin |
CN112773859A (en) * | 2021-03-15 | 2021-05-11 | 延安大学附属医院 | Dentifrice for treating dental fluorosis and preparation method thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101095890A (en) * | 2006-06-26 | 2008-01-02 | 赵品莉 | Mouth cavity medicine midbody panax japonicus composite total saponins |
-
2011
- 2011-05-23 CN CN2011101332208A patent/CN102793824A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101095890A (en) * | 2006-06-26 | 2008-01-02 | 赵品莉 | Mouth cavity medicine midbody panax japonicus composite total saponins |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104137979A (en) * | 2014-07-29 | 2014-11-12 | 桂林实力科技有限公司 | Fructus momordicae aspartame and preparation method thereof |
CN104137979B (en) * | 2014-07-29 | 2015-12-02 | 桂林实力科技有限公司 | A kind of mangosteen sweetener and preparation method thereof |
CN106466397A (en) * | 2015-08-14 | 2017-03-01 | 常昊 | Siraidia grosvenorii composite total saponin |
CN112773859A (en) * | 2021-03-15 | 2021-05-11 | 延安大学附属医院 | Dentifrice for treating dental fluorosis and preparation method thereof |
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Application publication date: 20121128 |