CN1895336B - Galactogogue oral liquid and its preparation - Google Patents
Galactogogue oral liquid and its preparation Download PDFInfo
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- CN1895336B CN1895336B CN200610014382A CN200610014382A CN1895336B CN 1895336 B CN1895336 B CN 1895336B CN 200610014382 A CN200610014382 A CN 200610014382A CN 200610014382 A CN200610014382 A CN 200610014382A CN 1895336 B CN1895336 B CN 1895336B
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Abstract
A Chinese lactagogue medicine in the form of oral liquid is prepared from medical alcohol, water, and 5 Chinese-medicinal materials including vaccaria seed, pangolin scales, Chinese angelica root, astragalus root, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of human Chinese medicine preparation and preparation method thereof, postpartum milk secretion obstacle, the puerperal physiology that this Chinese medicine is specially adapted to treat the puerpera who is caused by Different types of etiopathogenises such as recovers to delay at disease.
Background technology
The reason of cesarean lactation obstacle is many-sided, and aspects such as primiparity at advanced age, operation or non-operation practise midwifery, puerpera's physical ability, emotion, digestion, nutrition all can constitute individual reason.Modern women is many because complexity is at ordinary times lived and social work pressure, causes the endocrine disturbance of self easily, and causes the health status of health to be in imbalance state; Bad living habit such as usually some such as fat-reducing, cosmetic, cosmetology have also seriously influenced the health of health.Above-mentioned these having a delicate constitution all can cause the women to produce the time, deficiency of both QI and blood, deficiency and coldness, the stagnation of QI, stasis, its clinical manifestation are dysgalactia.Cause the puerpera can not normally be subjected to breast thus, puerpera's uterine contraction and endocrine physiological are restored balance to have a negative impact, and then causes the loss of puerpera's body constitution.And puerpera's dysgalactia also can directly cause neonatal nutrition and growth.To the treatment of cesarean lactation obstacle, how lack of standardization method among the people is a lot,, are difficult to observe its actual efficacy at present; And the Western medicine endocrine preparation is not remarkable to this curative effect, and side effect is many.Therefore still not having at present a kind of like products effective and without any side effects occurs.
Summary of the invention
The objective of the invention is by a kind of Galactogogue oral liquid and preparation method thereof is provided, be specially adapted to treat because the cesarean lactation obstacle that Different types of etiopathogenises causes and puerpera's physiology recover to delay.Thereby solved the problem that exists in the above-mentioned background technology.
Contain effective ingredient and medical alcohol and water in raw material of Chinese medicine Semen Vaccariae, Squama Manis, Fructus Liquidambaris, Radix Angelicae Sinensis, the Radix Astragali in the composition of a kind of Galactogogue oral liquid of the present invention, it is brown that finished product is that outward appearance is, and solid content is not less than 8% preparation medicinal liquid.
The manufacture method of Galactogogue oral liquid of the present invention can be carried out according to following program:
A. be unit with weight with crude drug Semen Vaccariae 10-30, Fructus Liquidambaris 5-20 part, Radix Angelicae Sinensis 5-20 part and Radix Astragali 10-30 part insert mix in the medical distilled water that is equivalent to 3 times of its gross weights soak 15-30 hour after, add the medical distilled water be equivalent to 3 times of weight of crude drug once more and boiled 30 minutes, the cooling back is boiled with 60 ℃ of slow fire and is extracted A liquid after 60 minutes;
B. add the concentration be equivalent to crude drug weight and be 95% medical alcohol in above-mentioned residual medicine dreg, add the medical distilled water that is equivalent to 3 times of weight of crude drug again, heated and boiled is extracted B liquid;
C. above-mentioned A liquid and B liquid are mixed into C liquid;
D. sand is placed in the iron pan and to fry to 220 ℃--after-240 ℃, be that unit puts into crude drug Squama Manis 10-30 part and fried 10-15 minute again with weight;
E. according to crude drug: the part by weight of vinegar=10: 3.5 places vinegar in the pot, and the Squama Manis after the above-mentioned stir-fry is put into pot rapidly, treats burst apart gradually loose back airing and pulverizing to Powdered of described Squama Manis;
F. according to the Squama Manis powder after the processing: the medical alcohol of 95% concentration: after the part by weight of medical distilled water=1: 1: 3 mixed mentioned component, heated and boiled was cooled to 60 ℃ in 30 minutes, boil 120 minutes with slow fire after, get extracting solution D liquid;
G. above-mentioned C liquid and D liquid are mixed, filter the back adding and be equivalent to above-mentioned raw materials medicine gross weight 20---50 medical distilled water doubly, promptly can be made into finished product.
Above-mentioned crude drug derives from the commercially available process of preparing Chinese medicine direct useful commercial up to standard, and its standard should meet the regulation of the Pharmacopoeia of the People's Republic of China.
According to " blood being the mother of qi, qi as the commander of blood; Blood circulation depending on qi flow, stagnation of QI stasis " theory of Chinese medical science, the important pathology reason of puerpera's deficiency of both QI and blood is anemia and void, void then stagnates.Therefore when enriching blood, should reach work, and be the basis of smooth and easy blood while mending; During QI invigorating, make QI and blood phase shade, can reach the result of normal lactation to recover puerpera's normal physiological function with organic, strong QI-blood circulation in, the organizator.
In order to reach the above-mentioned requirements of theory of Chinese medical science, the present invention abides by Chinese medical theory, and the crude drug Semen Vaccariae of selecting for use is " monarch " medicine, belongs to the agent of activating blood circulation to dissipate blood stasis, and zoopery shows that 80% uterine cancer cell cAMP obviously increases, and isolated uterine shrinks to be strengthened.Fill blood, enriching blood stagnates, activating blood circulation to dissipate blood stasis is equipped with messenger drug and adjuvant drug on basic, dredging the meridian produces two-way function, can recover normal lactication and uterine contraction and restore, the balance endocrine reaches the effect that makes infant nutrition grow and recover puerpera's body constitution.The crude drug Fructus Liquidambaris is " making " medicine, and row is guaranteed the smooth and easy circulation of QI and blood between meridians between the intravital meridians of people.Radix Angelicae Sinensis, the Radix Astragali are respectively left and right ministerial drug, can reach the purpose of benefiting qi and nourishing blood.Squama Manis is an adjuvant drug, can run to scurry meridians alive between meridians.
Product of the present invention at the women between puerperal deficiency of both QI and blood be the basic reason of cesarean lactation obstacle, benefiting qi and nourishing blood is lived while mending when enriching blood, and makes it to become smooth and easy blood; During QI invigorating, then make QI and blood phase shade with, form organic strong QI-blood circulation in vivo, guaranteed the formation of puerpera's normal physiological function.Therefore product of the present invention meets the principle of the traditional Chinese medical science " the specimen tool is anxious, treating both the principal and the secondary aspects of a disease at the same time for symptomatic treatment in acute condition, radical treatment in chronic case ".By the clinical observation to nearly 3000 examples, product total effective rate of the present invention has reached 96%, no acute toxicity and chronic toxicity report.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is made detailed explanation:
Embodiment 1
With crude drug Semen Vaccariae 30 gram, Fructus Liquidambaris 10 grams, Radix Angelicae Sinensis 10 grams and the Radix Astragali 20 grams insert mix in the 210 gram medical distilled waters soak 30 hours after, the medical distilled waters that add 210 grams once more boiled 30 minutes, cooling is boiled with 60 ℃ of slow fire and is extracted A liquid after 60 minutes;
B. adding 70 gram concentration are 95% medical alcohol in the above-mentioned residual medicine dreg, add the medical distilled waters of 210 grams again, and heated and boiled is extracted B liquid;
C. above-mentioned A liquid and B liquid are mixed into C liquid;
D. sand is placed in the iron pan and fry after 240 ℃, put into crude drug Squama Manis 30 grams and fried again 15 minutes;
E. 10.5 gram vinegars are placed in the pot, the Squama Manis after the above-mentioned stir-fry is put into pot rapidly, treat burst apart gradually loose back airing and pulverizing of described Squama Manis to Powdered;
F. according to the Squama Manis powder after the processing: the medical alcohol of 95% concentration: after the part by weight of medical distilled water=1: 1: 3 mixed mentioned component, heated and boiled was cooled to 60 ℃ in 30 minutes, boil 120 minutes with slow fire after, get extracting solution D liquid;
G. above-mentioned C liquid and D liquid are mixed, filter the back and add 2000 gram medical distilled waters and fully mix the back bottling, promptly can be made into solid content and be not less than 8% finished product.
Embodiment 2
Crude drug Semen Vaccariae 20 gram, Fructus Liquidambaris 5 grams, Radix Angelicae Sinensis 5 grams and the Radix Astragali 30 grams are inserted mix in the medical distilled waters of 90 grams soak 20 hours after, add 90 gram medical distilled waters once more and boiled 30 minutes, cooling is boiled with 60 ℃ of slow fire and is extracted A liquid after 60 minutes;
B. adding 60 gram concentration are 95% medical alcohol in the above-mentioned residual medicine dreg, add 180 gram medical distilled waters again, and heated and boiled is extracted B liquid;
C. above-mentioned A liquid and B liquid are mixed into C liquid;
D. sand is placed in the iron pan and fry after 220 ℃, put into crude drug Squama Manis 20 grams and fried again 13 minutes;
E. 7.5 gram vinegars are placed in the pot, the Squama Manis after the above-mentioned stir-fry is put into pot rapidly, treat burst apart gradually loose back airing and pulverizing of described Squama Manis to Powdered;
F. according to the Squama Manis powder after the processing: the medical alcohol of 95% concentration: after the part by weight of medical distilled water=1: 1: 3 mixed mentioned component, heated and boiled was cooled to 60 ℃ in 30 minutes, boil 120 minutes with slow fire after, get extracting solution D liquid;
G. above-mentioned C liquid and D liquid are mixed, filter the back and add 2800 gram medical distilled waters and fully mix the back bottling, promptly can be made into solid content and be not less than 8% finished product.
Embodiment 3
With crude drug Semen Vaccariae 10 gram, Fructus Liquidambaris 20 grams, Radix Angelicae Sinensis 20 grams and the Radix Astragali 20 grams insert mix in the 210 gram medical distilled waters soak 15 hours after, add 210 gram medical distilled waters once more and boiled 30 minutes, cooling is boiled with 60 ℃ of slow fire and is extracted A liquid after 60 minutes;
B. adding 70 gram concentration are 95% medical alcohol in the above-mentioned residual medicine dreg, add 210 gram medical distilled waters again, and B liquid is extracted in cooling after the heated and boiled;
C. above-mentioned A liquid and B liquid are mixed into C liquid;
D. sand is placed in the iron pan and fry after 230 ℃, put into crude drug Squama Manis 10 grams and fried again 10 minutes;
E. 3.5 gram vinegars are placed in the pot, the Squama Manis after the above-mentioned stir-fry is put into pot rapidly, treat burst apart gradually loose back airing and pulverizing of described Squama Manis to Powdered;
F. according to the Squama Manis powder after the processing: the medical alcohol of 95% concentration: after the part by weight of medical distilled water=1: 1: 3 mixed mentioned component, heated and boiled was cooled to 60 ℃ in 30 minutes, boil 120 minutes with slow fire after, get extracting solution D liquid;
G. above-mentioned C liquid and D liquid are mixed, filter the back and add 4000 gram medical distilled waters and fully mix the back bottling, promptly can be made into solid content and be not less than 8% finished product.
Embodiment 4
With crude drug Semen Vaccariae 20 gram, Fructus Liquidambaris 15 grams, Radix Angelicae Sinensis 15 grams and the Radix Astragali 20 grams insert mix in the 210 gram medical distilled waters soak 25 hours after, add 210 gram medical distilled waters once more and boiled 30 minutes, cooling is boiled with 60 ℃ of slow fire and is extracted A liquid after 60 minutes;
B. adding 70 gram concentration are 95% medical alcohol in the above-mentioned residual medicine dreg, add 210 gram medical distilled waters again, and heated and boiled is extracted B liquid;
C. above-mentioned A liquid and B liquid are mixed into C liquid;
D. sand is placed in the iron pan and fry after 240 ℃, put into crude drug Squama Manis 20 grams and fried again 15 minutes;
E. 7 gram vinegars are placed in the pot, the Squama Manis after the above-mentioned stir-fry is put into pot rapidly, treat burst apart gradually loose back airing and pulverizing of described Squama Manis to Powdered;
F. according to the Squama Manis powder after the processing: the medical alcohol of 95% concentration: after the part by weight of medical distilled water=1: 1: 3 mixed mentioned component, heated and boiled was cooled to 60 ℃ in 30 minutes, boil 120 minutes with slow fire after, get extracting solution D liquid;
G. above-mentioned C liquid and D liquid are mixed, filter the back and add 3600 gram medical distilled waters and fully mix the back bottling, promptly can be made into solid content and be not less than 8% finished product.
Embodiment 5
With crude drug Semen Vaccariae 20 gram, Fructus Liquidambaris 10 grams, Radix Angelicae Sinensis 20 grams and the Radix Astragali 20 grams insert mix in the 210 gram medical distilled waters soak 20 hours after, add the 210 gram medical distilled waters be equivalent to 3 times of weight of crude drug once more and boiled 30 minutes, cooling is boiled with 60 ℃ of slow fire and is extracted A liquid after 60 minutes;
B. adding 70 gram concentration are 95% medical alcohol in the above-mentioned residual medicine dreg, add 210 gram medical distilled waters again, and heated and boiled is extracted B liquid;
C. above-mentioned A liquid and B liquid are mixed into C liquid;
D. sand is placed in the iron pan and fry after 230 ℃, put into crude drug Squama Manis 20 grams and fried again 15 minutes;
E. 7 gram vinegars are placed in the pot, the Squama Manis after the above-mentioned stir-fry is put into pot rapidly, treat burst apart gradually loose back airing and pulverizing of described Squama Manis to Powdered;
F. according to the Squama Manis powder after the processing: the medical alcohol of 95% concentration: after the part by weight of medical distilled water=1: 1: 3 mixes mentioned component,, heated and boiled was cooled to 60 ℃ in 30 minutes, boil 120 minutes with slow fire after, get extracting solution D liquid;
G. above-mentioned C liquid and D liquid are mixed, filter the back and add 1800 gram medical distilled waters and fully mix the back bottling, promptly can be made into solid content and be not less than 8% finished product.
Claims (2)
1. the manufacture method of a Galactogogue oral liquid is characterized in that described manufacture method is:
A. be unit with weight with crude drug Semen Vaccariae 10-30 part, Fructus Liquidambaris 5-20 part, Radix Angelicae Sinensis 5-20 part and Radix Astragali 10-30 part insert mix in the medical distilled water that is equivalent to 3 times of its gross weights soak 15-30 hour after, add the medical distilled water be equivalent to 3 times of weight of crude drug once more and boiled 30 minutes, cooling is boiled with 60 ℃ of slow fire and is extracted A liquid after 60 minutes;
B. add the concentration be equivalent to crude drug weight in the above-mentioned residual medicine dreg and be 95% medical alcohol, add the medical distilled water that is equivalent to 3 times of weight of crude drug again, heated and boiled is extracted B liquid;
C. above-mentioned A liquid and B liquid are mixed into C liquid;
D. sand being placed in the iron pan and to fry after 220 ℃-240 ℃, is that unit puts into crude drug Squama Manis 10-30 part and fried 10-15 minute again with weight;
E. according to crude drug: the part by weight of vinegar=10: 3.5 places vinegar in the pot, and the Squama Manis after the above-mentioned stir-fry is put into pot rapidly, treats burst apart gradually loose back airing and pulverizing to Powdered of described Squama Manis;
F. according to the Squama Manis powder: the medical alcohol of 95% concentration: after the part by weight of medical distilled water=1: 1: 3 mixed mentioned component, heated and boiled was cooled to 60 ℃ in 30 minutes, boil 120 minutes with slow fire after, get extracting solution D liquid;
G. above-mentioned C liquid and D liquid are mixed, add the medical distilled water that is equivalent to above-mentioned raw materials medicine gross weight 20-50 times after filtering and fully mix the back bottling, promptly can be made into finished product.
2. it is brown that Galactogogue oral liquid that method according to claim 1 is made, the finished product that it is characterized in that described oral liquid are that outward appearance is, and solid content is not less than 8% preparation medicinal liquid.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200610014382A CN1895336B (en) | 2006-06-20 | 2006-06-20 | Galactogogue oral liquid and its preparation |
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| CN200610014382A CN1895336B (en) | 2006-06-20 | 2006-06-20 | Galactogogue oral liquid and its preparation |
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| CN1895336B true CN1895336B (en) | 2010-05-12 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101524396B (en) * | 2008-11-25 | 2011-05-04 | 杨波 | Traditional Chinese medicine preparation for treating hypogalactia of lying-in woman |
| CN102048890B (en) * | 2009-11-10 | 2014-08-13 | 天士力制药集团股份有限公司 | Traditional Chinese medicine composition with galactagogue effect and preparation method thereof |
| CN102670830A (en) * | 2012-05-22 | 2012-09-19 | 徐州三源医药科技有限公司 | Lactation promoting soup and preparation method thereof |
| CN104666397A (en) * | 2013-11-30 | 2015-06-03 | 黄思齐 | Medicine for treating hypogalactia disease |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1060366C (en) * | 1996-10-04 | 2001-01-10 | 湖南省水产科学研究所 | Luteotropic preparation for parturient women and its producing technology |
| CN1233395C (en) * | 2003-12-10 | 2005-12-28 | 山东师范大学 | Oral liquid for treating postpartum hypogalactia and its preparation |
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2006
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1060366C (en) * | 1996-10-04 | 2001-01-10 | 湖南省水产科学研究所 | Luteotropic preparation for parturient women and its producing technology |
| CN1233395C (en) * | 2003-12-10 | 2005-12-28 | 山东师范大学 | Oral liquid for treating postpartum hypogalactia and its preparation |
Non-Patent Citations (7)
| Title |
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| 何玉坤.针刺加通乳汤治疗产后缺乳症32例疗效观察.冶金医药情报9 5.1992,9(5),第298页. |
| 何玉坤.针刺加通乳汤治疗产后缺乳症32例疗效观察.冶金医药情报9 5.1992,9(5),第298页. * |
| 李钟鸣.中医药治疗产后泌乳不足的临床和实验研究进展.中医药信息 5.1998,(5),18-20页. |
| 李钟鸣.中医药治疗产后泌乳不足的临床和实验研究进展.中医药信息 5.1998,(5),18-20页. * |
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